leukoaraiosis

Summary

Summary: Non-specific white matter changes in the BRAIN, often seen after age 65. Changes include loss of AXONS; MYELIN pallor, GLIOSIS, loss of ependymal cells, and enlarged perivascular spaces. Leukoaraiosis is a risk factor for DEMENTIA and CEREBROVASCULAR DISORDERS.

Top Publications

  1. ncbi Progression of white matter hyperintensities and incidence of new lacunes over a 3-year period: the Leukoaraiosis and Disability study
    Alida A Gouw
    Department of Neurology, Alzheimer Center and Image Analysis Center, Vrije Universiteit Medical Center, PO Box 7057, 1007 MB Amsterdam, The Netherlands
    Stroke 39:1414-20. 2008
  2. pmc Vascular dementia in leukoaraiosis may be a consequence of capillary loss not only in the lesions, but in normal-appearing white matter and cortex as well
    William R Brown
    Department of Radiology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
    J Neurol Sci 257:62-6. 2007
  3. ncbi Age-related cerebral white matter disease (leukoaraiosis): a review
    Basil E Grueter
    Stroke Prevention Research Unit, Nuffield Department of Clinical Neurosciences Neurology Division, University of Oxford, Headington, Oxford OX3 9DU, UK
    Postgrad Med J 88:79-87. 2012
  4. ncbi Leukoaraiosis
    Mike O'Sullivan
    Humboldt Research Fellow, Neurologische Klinik, Klinikum Grosshadern, Marchioninstrasse 15, 81377 Munchen, Germany
    Pract Neurol 8:26-38. 2008
  5. ncbi Whole-brain histogram and voxel-based analyses of diffusion tensor imaging in patients with leukoaraiosis: correlation with motor and cognitive impairment
    R Della Nave
    Radiodiagnostic Section, Department of Clinical Physiopathology, University of Florence, Florence, and Medical Physics, Azienda Ospedaliera Universitaria Pisana, Pisa, Italy
    AJNR Am J Neuroradiol 28:1313-9. 2007
  6. ncbi Cerebral small-vessel disease and decline in information processing speed, executive function and memory
    Niels D Prins
    Department of Neurology, Erasmus Medical Center, Rotterdam, The Netherlands
    Brain 128:2034-41. 2005
  7. ncbi Homocysteine and its relationship to stroke subtypes in a UK black population: the south London ethnicity and stroke study
    Usman Khan
    Centre for Clinical Neuroscience, St George s University of London, London, UK
    Stroke 39:2943-9. 2008
  8. ncbi Blood-brain barrier permeability is increased in normal-appearing white matter in patients with lacunar stroke and leucoaraiosis
    R Topakian
    Centre for Clinical Neuroscience, St George s University of London, Cranmer Terrace, London SW17 0RE, UK
    J Neurol Neurosurg Psychiatry 81:192-7. 2010
  9. ncbi Progression of leukoaraiosis and cognition
    Reinhold Schmidt
    Department of Neurology, Medical University of Graz, Graz, Austria
    Stroke 38:2619-25. 2007
  10. ncbi Selective reduction of blood flow to white matter during hypercapnia corresponds with leukoaraiosis
    Daniel M Mandell
    Department of Medical Imaging, Toronto Western Hospital, Toronto, Ontario M5T 2S8, Canada
    Stroke 39:1993-8. 2008

Research Grants

Detail Information

Publications208 found, 100 shown here

  1. ncbi Progression of white matter hyperintensities and incidence of new lacunes over a 3-year period: the Leukoaraiosis and Disability study
    Alida A Gouw
    Department of Neurology, Alzheimer Center and Image Analysis Center, Vrije Universiteit Medical Center, PO Box 7057, 1007 MB Amsterdam, The Netherlands
    Stroke 39:1414-20. 2008
    ..We studied the natural course of white matter hyperintensities (WMH) and lacunes, the main MRI representatives of small vessel disease, over time and evaluated possible predictors for their development...
  2. pmc Vascular dementia in leukoaraiosis may be a consequence of capillary loss not only in the lesions, but in normal-appearing white matter and cortex as well
    William R Brown
    Department of Radiology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
    J Neurol Sci 257:62-6. 2007
    We investigated capillary density in 12 subjects with leukoaraiosis (LA), in 9 age-matched normal subjects, in 7 cases of Alzheimer's disease (AD), and 4 after whole-brain irradiation for brain tumors...
  3. ncbi Age-related cerebral white matter disease (leukoaraiosis): a review
    Basil E Grueter
    Stroke Prevention Research Unit, Nuffield Department of Clinical Neurosciences Neurology Division, University of Oxford, Headington, Oxford OX3 9DU, UK
    Postgrad Med J 88:79-87. 2012
    ..a lot of data are now available on the epidemiology, risk factors, clinical consequences and prognosis of leukoaraiosis, some of this information is conflicting...
  4. ncbi Leukoaraiosis
    Mike O'Sullivan
    Humboldt Research Fellow, Neurologische Klinik, Klinikum Grosshadern, Marchioninstrasse 15, 81377 Munchen, Germany
    Pract Neurol 8:26-38. 2008
    b>Leukoaraiosis describes diffuse white matter abnormalities on CT or MR brain scans, often seen in the normal elderly and in association with vascular risk factors such as hypertension, or in the context of cognitive impairment...
  5. ncbi Whole-brain histogram and voxel-based analyses of diffusion tensor imaging in patients with leukoaraiosis: correlation with motor and cognitive impairment
    R Della Nave
    Radiodiagnostic Section, Department of Clinical Physiopathology, University of Florence, Florence, and Medical Physics, Azienda Ospedaliera Universitaria Pisana, Pisa, Italy
    AJNR Am J Neuroradiol 28:1313-9. 2007
    Cerebral white matter changes, termed leukoaraiosis (LA), appearing as areas of increased signal intensity in T2-weighted MR images, are common in elderly subjects, but the possible correlation of LA with cognitive or motor deficit has ..
  6. ncbi Cerebral small-vessel disease and decline in information processing speed, executive function and memory
    Niels D Prins
    Department of Neurology, Erasmus Medical Center, Rotterdam, The Netherlands
    Brain 128:2034-41. 2005
    ..Our results suggest that in older people cerebral small-vessel disease may contribute to cognitive decline by affecting information processing speed and executive function...
  7. ncbi Homocysteine and its relationship to stroke subtypes in a UK black population: the south London ethnicity and stroke study
    Usman Khan
    Centre for Clinical Neuroscience, St George s University of London, London, UK
    Stroke 39:2943-9. 2008
    ..In white populations elevated homocysteine has been associated with SVD, especially confluent leukoaraiosis, and may be acting through endothelial dysfunction...
  8. ncbi Blood-brain barrier permeability is increased in normal-appearing white matter in patients with lacunar stroke and leucoaraiosis
    R Topakian
    Centre for Clinical Neuroscience, St George s University of London, Cranmer Terrace, London SW17 0RE, UK
    J Neurol Neurosurg Psychiatry 81:192-7. 2010
    ....
  9. ncbi Progression of leukoaraiosis and cognition
    Reinhold Schmidt
    Department of Neurology, Medical University of Graz, Graz, Austria
    Stroke 38:2619-25. 2007
    b>Leukoaraiosis is used interchangeably with the term white matter lesions on MRI and seen to some degree in more than half of the routine scans in older persons...
  10. ncbi Selective reduction of blood flow to white matter during hypercapnia corresponds with leukoaraiosis
    Daniel M Mandell
    Department of Medical Imaging, Toronto Western Hospital, Toronto, Ontario M5T 2S8, Canada
    Stroke 39:1993-8. 2008
    Age-related white matter disease (leukoaraiosis) clusters in bands in the centrum semiovale, about the occipital and frontal horns of the lateral ventricles, in the corpus callosum, and internal capsule...
  11. ncbi Impact of white matter hyperintensities scoring method on correlations with clinical data: the LADIS study
    Elisabeth C W van Straaten
    Department of Neurology and Alzheimer Center, VU Medical Center, Amsterdam, The Netherlands
    Stroke 37:836-40. 2006
    ..Associations may depend on the method used for measuring WMH. We investigated the ability of different WMH scoring methods to detect differences in WMH load between groups with and without symptoms...
  12. doi Metabolic syndrome is associated with silent ischemic brain lesions
    Hirokazu Bokura
    Stroke 39:1607-9. 2008
    ..We examined the association of MetS with the prevalence of silent brain infarction, periventricular hyperintensity, and subcortical white matter lesions in healthy adults...
  13. ncbi Pathogenesis of leukoaraiosis: role of jugular venous reflux
    Chih Ping Chung
    Department of Neurology, Taipei Veterans General Hospital, Taipei, Taiwan
    Med Hypotheses 75:85-90. 2010
    b>Leukoaraiosis (LA) is a major cause of vascular dementia and disability in the elderly. Age and hypertension are the most two important risk factors. Despite its clinical significance, the etiology is so far unclear...
  14. ncbi Risk of rapid global functional decline in elderly patients with severe cerebral age-related white matter changes: the LADIS study
    Domenico Inzitari
    Department of Neurological and Psychiatric Sciences, University of Florence, Florence, Italy
    Arch Intern Med 167:81-8. 2007
    ..The LADIS (LeukoAraiosis and DISability) Study primarily aims to assess ARWMCs as a determinant of global functional decline in the ..
  15. ncbi Pulse pressure correlates with leukoaraiosis in Alzheimer disease
    Ae Young Lee
    Department of Neurology, Chungnam National University, Joong ku, Taejon 301 721, Republic of Korea
    Arch Gerontol Geriatr 42:157-66. 2006
    ..We found a significant relationship between PP and cerebral white matter changes (WMCs) in AD. PP changes correlate with leukoaraiosis in AD.
  16. ncbi Abnormalities of magnetic resonance spectroscopy and diffusion tensor imaging are correlated with executive dysfunction in patients with ischemic leukoaraiosis
    Chuo Li
    Department of Internal Medicine, Guangzhou Eighth People s Hospital, Guangzhou, China
    J Clin Neurosci 19:718-22. 2012
    ..tensor imaging (DTI) results have been observed in the periventricular white matter in patients with ischemic leukoaraiosis (ILA)...
  17. ncbi Increased cerebral arterial pulsatility in patients with leukoaraiosis: arterial stiffness enhances transmission of aortic pulsatility
    Alastair J S Webb
    Stroke Prevention Research Unit, University of Oxford, Oxford, UK
    Stroke 43:2631-6. 2012
    ..In the absence of previous studies in patients with recent transient ischemic attack or stroke, we determined the associations between leukoaraiosis and aortic and middle cerebral artery stiffness and pulsatility.
  18. ncbi Silent cerebral microbleeds on susceptibility-weighted imaging of patients with ischemic stroke and leukoaraiosis
    Tianli Gao
    Department of Neurology, Capital Medical University, Beijing Anzhen Hospital, Chaoyang District, Beijing 100029, China
    Neurol Res 30:272-6. 2008
    ..We investigated the incidence of microbleeds among different ischemic stroke subtypes and the severity of leukoaraiosis.
  19. ncbi Ischemic blood-brain barrier and amyloid in white matter as etiological factors in leukoaraiosis
    Ryszard Pluta
    Laboratory of Ischemic and Neurodegenerative Brain Research, Department of Neurodegenerative Disorders, Medical Research Centre, Polish Academy of Sciences, Pawinskiego 5 Str, 02 106 Warsaw, Poland
    Acta Neurochir Suppl 102:353-6. 2008
    ..Periventricular white matter changes in ischemic and Alzheimer's disease brain, referred to as leukoaraiosis, are responsible for changes in memory, cognition and behavior...
  20. ncbi Severity of leukoaraiosis in large vessel atherosclerotic disease
    A Chutinet
    J Philip Kistler Stroke Research Center, Department of Neurology, Massachusetts General Hospital, Boston, MA 02114, USA
    AJNR Am J Neuroradiol 33:1591-5. 2012
    The severity of white matter hyperintensity, or leukoaraiosis, is a marker of cerebrovascular disease...
  21. ncbi Silent brain infarcts, leukoaraiosis, and long-term prognosis in young ischemic stroke patients
    J Putaala
    Department of Neurology, Helsinki University Central Hospital, Haartmaninkatu 4, FIN 00290, Helsinki, Finland
    Neurology 76:1742-9. 2011
    To investigate prognostic relevance of silent brain infarcts (SBIs) and leukoaraiosis (LA) in young patients with ischemic stroke.
  22. ncbi Periventricular and deep white matter leukoaraiosis have a closer association with cerebral microbleeds than age
    S Yamada
    Department of Neurosurgery, Shiga Medical Center for Adults, Shiga, Japan
    Eur J Neurol 19:98-104. 2012
    Taking an advantage of the high sensitivity of 3D T2*-weighted gradient-recalled-echo (GRE) imaging to cerebral microbleeds, we investigated the relationship between cerebral microbleeds and leukoaraiosis.
  23. ncbi Low levels of plasma soluble receptor for advanced glycation end products are associated with severe leukoaraiosis in acute stroke patients
    Chiaki Yokota
    Cerebrovascular Division, Department of Medicine, National Cardiovascular Center Suita, Osaka, Japan
    J Neurol Sci 287:41-4. 2009
    ..Severe leukoaraiosis on brain MR images, high NIHSS scores on admission, cigarette smoking, and normal estimated glomerular ..
  24. pmc Age-associated leukoaraiosis and cortical cholinergic deafferentation
    N I Bohnen
    VA Ann Arbor Healthcare System, GRECC, MI, USA
    Neurology 72:1411-6. 2009
    To investigate the relationship between age-associated MRI leukoaraiosis or white matter hyperintensities (WMH) and cortical acetylcholinesterase (AChE) activity.
  25. ncbi Significant association between leukoaraiosis and metabolic syndrome in healthy subjects
    K Park
    Department of Neurosurgery, Medical School, Kochi University, Kohasu, Okohcho, Nankokushi, Kochi, Japan
    Neurology 69:974-8. 2007
    To investigate the relationship between leukoaraiosis (LA), which has been considered as an intermediate substitute of ischemic brain damages, and metabolic syndrome (MetS), which attracts attention as a risk factor for cerebrovascular ..
  26. pmc Leukoaraiosis and stroke
    Eric E Smith
    Department of Clinical Neurosciences, Hotchkiss Brain Institute, University of Calgary, Canada
    Stroke 41:S139-43. 2010
    b>Leukoaraiosis is a common finding in stroke patients and has been strongly associated with risk of incident stroke and dementia. Leukoaraiosis may also be an independent predictor of stroke outcomes...
  27. ncbi Microbleed topography, leukoaraiosis, and cognition in probable Alzheimer disease from the Sunnybrook dementia study
    Jacqueline A Pettersen
    Division of Neurology, Department of Medicine, Sunnybrook Health Sciences Centre, A421 2075 Bayview Ave, Toronto, ON M4N 3M5, Canada
    Arch Neurol 65:790-5. 2008
    ..Microbleeds are hemosiderin deposits around small vessels and are well visualized with T2*-weighted gradient-recalled echo (GRE) imaging...
  28. ncbi The severity of leukoaraiosis correlates with the clinical phenotype of Parkinson's disease
    Seung Jae Lee
    Department of Neurology, The Catholic University of Korea, Kangnam St Mary s Hospital, 505 Banpo Dong, Seocho Gu, Seoul 137 701, South Korea
    Arch Gerontol Geriatr 49:255-9. 2009
    The impact of leukoaraiosis on Parkinson's disease (PD) has not been completely explained. We evaluated 141 patients with PD to assess the role of leukoaraiosis and determined its influence on the clinical phenotype of PD...
  29. ncbi Cognitive function correlates with frontal white matter apparent diffusion coefficients in patients with leukoaraiosis
    Miguel Viana-Baptista
    Neurology Department, Hospital de Egas Moniz CHLO, Faculty of Medical Sciences, Universidade Nova de Lisboa, Portugal
    J Neurol 255:360-6. 2008
    ....
  30. ncbi Urinary complaints in nondisabled elderly people with age-related white matter changes: the Leukoaraiosis And DISability (LADIS) Study
    Anna Poggesi
    Department of Neurological and Psychiatric Sciences, University of Florence, Florence, Italy
    J Am Geriatr Soc 56:1638-43. 2008
    ..To investigate, in a cohort of nondisabled elderly people, the association between urinary complaints and severity of age-related white matter changes (ARWMC)...
  31. pmc Genomic susceptibility Loci for brain atrophy, ventricular volume, and leukoaraiosis in hypertensive sibships
    Stephen T Turner
    Division of Nephrology and Hypertension, Department of Internal Medicine, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA
    Arch Neurol 66:847-57. 2009
    ..resonance imaging (MRI) measures of brain atrophy, ventricular, and subcortical white matter hyperintensity (leukoaraiosis) in 689 non-Hispanic white (673 sibling pairs; median age, 61 years) and 544 non-Hispanic black participants (..
  32. ncbi Diffuse tract damage in the hemispheric deep white matter may correlate with global cognitive impairment and callosal atrophy in patients with extensive leukoaraiosis
    Y Otsuka
    Human Brain Research Center, Kyoto University Graduate School of Medicine, Kyoto, Japan
    AJNR Am J Neuroradiol 33:726-32. 2012
    Patients with extensive leukoaraiosis are at high risk for vascular dementia. However, these patients exhibit variable severity of global cognitive impairment correlating with callosal atrophy...
  33. ncbi Mild cognitive impairment and event-related potentials in patients with cerebral atrophy and leukoaraiosis
    Ryszard Podemski
    Department of Neurology, University of Medicine in Wroclaw, Borowska 213, 50 556, Wroclaw, Poland
    Neurol Sci 29:411-6. 2008
    The influence of cerebral atrophy and leukoaraiosis (LA) on the degree and profile of cognitive impairment remains unclear.
  34. ncbi Leukoaraiosis predicts hidden global functioning impairment in nondisabled older people: the LADIS (Leukoaraiosis and Disability in the Elderly) Study
    Leonardo Pantoni
    Department of Neurological and Psychiatric Sciences, University of Florence, Florence, Italy
    J Am Geriatr Soc 54:1095-101. 2006
    To determine whether leukoaraiosis severity is independently associated with differences in global functioning in nondisabled elderly patients.
  35. ncbi Quantitation of brain tissue changes associated with white matter hyperintensities by diffusion-weighted and magnetization transfer imaging: the LADIS (Leukoaraiosis and Disability in the Elderly) study
    Stefan Ropele
    Department of Neurology, Medical University of Graz, Austria
    J Magn Reson Imaging 29:268-74. 2009
    ..To explore the value of diffusion-weighted imaging (DWI) and magnetization transfer imaging (MTI) for the improved detection and quantification of cerebral tissue changes associated with ageing and white matter hyperintensities (WMH)...
  36. pmc Leukoaraiosis and increased cerebral susceptibility to ischemia: lack of confounding by carotid disease
    Ursula G Schulz
    Stroke Prevention Research Unit, Nuffield Department of Neurosciences, John Radcliffe Hospital, Oxford, UK
    J Am Heart Assoc 2:e000261. 2013
    b>Leukoaraiosis is associated with an increased risk of stroke, but the underlying mechanism remains uncertain, as do the associations with other risk factors, such as carotid disease...
  37. ncbi Clinical, radiological and pathological correlates of leukoaraiosis
    E Auriel
    Stroke Unit, Department of Neurology, Tel Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    Acta Neurol Scand 123:41-7. 2011
    b>Leukoaraiosis is characterized by an abnormal appearance of the brain white matter on imaging. Its pathogenesis is still a matter of investigation...
  38. ncbi Callosal tissue loss parallels subtle decline in psychomotor speed. a longitudinal quantitative MRI study. The LADIS Study
    Hanna Jokinen
    Department of Neurology, Helsinki University Central Hospital Helsinki, Finland
    Neuropsychologia 50:1650-5. 2012
    ..The adverse effect of CC tissue loss on psychomotor function may be driven by altered interhemispheric information transfer between homologous cortical areas...
  39. pmc Leukoaraiosis and collaterals in acute ischemic stroke
    Nerses Sanossian
    Department of Neurology, University of Southern California, CA, USA
    J Neuroimaging 21:232-5. 2011
    ..collaterals in acute stroke with the presence, extent, and distribution of white matter changes, so-called Leukoaraiosis, in an effort to determine if Leukoaraiosis indicates chronic cerebral hypoperfusion and/or is associated with ..
  40. pmc Cerebral amyloid angiopathy burden associated with leukoaraiosis: a positron emission tomography/magnetic resonance imaging study
    M Edip Gurol
    Hemorrhagic Stroke Research Center, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA Department of Biostatistics, Harvard School of Public Health, Boston, MA
    Ann Neurol 73:529-36. 2013
    ..would correlate with the extent of magnetic resonance imaging (MRI) white matter hyperintensities (WMH; or leukoaraiosis) in patients with high vascular amyloid deposition (cerebral amyloid angiopathy [CAA]) but not in patients ..
  41. ncbi [Age-related white matter lesions (leukoaraiosis): an update]
    Yukio Miki
    Department of Radiology, Osaka City University Graduate School of Medicine, Japan
    Brain Nerve 65:789-99. 2013
    b>Leukoaraiosis (age-related white matter hyperintensities) is the most frequently seen lesion on brain magnetic resonance (MR) images...
  42. ncbi [Characteristics of cognitive impairment in patients with leukoaraiosis]
    Jun Liang Yuan
    Department of Neurology, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, China
    Zhonghua Yi Xue Za Zhi 92:147-51. 2012
    To explore the characteristics of cognitive impairment in patients with leukoaraiosis (LA).
  43. pmc Severity of leukoaraiosis determines clinical phenotype after brain infarction
    E M Arsava
    A A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, 149 13th Street, Room 2301, Charlestown, MA 02129, USA
    Neurology 77:55-61. 2011
    To determine whether the extent of leukoaraiosis, a composite marker of baseline brain integrity, differed between patients with TIA with diffusion-weighted imaging (DWI) evidence of infarction (transient symptoms with infarction [TSI]) ..
  44. ncbi Leukoaraiosis predicts the need for intraoperative shunt placement during carotid endarterectomy
    Ali Arshad
    Department of Vascular and Endovascular Surgery, University Hospitals, Nottingham, UK
    Perspect Vasc Surg Endovasc Ther 21:173-7. 2009
    ..This may reflect an association with impaired cerebral hemodynamics. Hence, the authors studied whether ipsilateral WMHLs predict shunt requirement on clamping as an indicator of hemodynamic compromise...
  45. ncbi Leukoaraiosis predicts cortical infarct volume after distal middle cerebral artery occlusion
    Nils Henninger
    From the Departments of Neurology N H, M A K, J Z, M M, R P G and Psychiatry N H, University of Massachusetts Medical School, Worcester
    Stroke 45:689-95. 2014
    b>Leukoaraiosis (LA) predominantly affects the subcortical white matter, but mounting evidence suggests an association with cortical microvascular dysfunction and potentially decreased cortical ischemic tolerance...
  46. ncbi Corpus callosum tissue loss and development of motor and global cognitive impairment: the LADIS study
    Kristian S Frederiksen
    Memory Disorders Research Group, Department of Neurology, Copenhagen University Hospital, Copenhagen, The Netherlands
    Dement Geriatr Cogn Disord 32:279-86. 2011
    ..To examine the impact of corpus callosum (CC) tissue loss on the development of global cognitive and motor impairment in the elderly...
  47. pmc In vivo vascular hallmarks of diffuse leukoaraiosis
    Jinsoo Uh
    Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    J Magn Reson Imaging 32:184-90. 2010
    To characterize multiple patterns of vascular changes in leukoaraiosis using in vivo magnetic resonance imaging (MRI) techniques.
  48. ncbi Is high oral dose L-arginine intake effective in leukoaraiosis? Preliminary data, study protocol and expert's opinion
    Rocco Salvatore Calabrò
    IRCCS Centro Neurolesi Bonino Pulejo S S 113 via Palermo, Messina, Italy
    Curr Aging Sci 6:170-7. 2013
    ..The pathogenesis of leukoaraiosis still has not been thoroughly acknowledged, even though chronic ischemia with consequent arteriolosclerosis ..
  49. ncbi Leukoaraiosis is associated with genes regulating blood-brain barrier homeostasis in ischaemic stroke patients
    I Fernandez-Cadenas
    Department of Neurology, Neurovascular Research Laboratory and Neurovascular Unit, Vall d Hebron University Hospital, Barcelona, Spain
    Eur J Neurol 18:826-35. 2011
    The biologic agents causing leukoaraiosis are unknown. Our aim was to study the genetic basis of leukoaraiosis.
  50. ncbi Relationship of deep white matter hyperintensities and cerebral blood flow in severe carotid artery stenosis
    T Patankar
    Imaging Science and Biomedical Engineering, School of Medicine, University of Manchester, Manchester, UK
    Eur J Neurol 13:10-6. 2006
    b>Leukoaraiosis (LA) has been associated with abnormalities of both large and small blood vessels...
  51. ncbi Common genetic variants of the mitochondrial trafficking system and mitochondrial uncoupling proteins affect the development of two slowly developing demyelinating disorders, leukoaraiosis and multiple sclerosis
    Z Szolnoki
    Department of Neurology and Cerebrovascular Diseases, Pandy County Hospital, Gyula, Hungary
    Curr Med Chem 17:3583-90. 2010
    ..In this context, this article discusses the roles of genetic variants of the kinesin motor proteins and UCPs in slowly developing diseases of the white matter of the brain as multiple sclerosis and leukoaraiosis.
  52. ncbi Reduced N-acetylaspartate is consistent with axonal dysfunction in cerebral small vessel disease
    Arani Nitkunan
    Centre for Clinical Neuroscience, St George s, University of London, London, UK
    NMR Biomed 22:285-91. 2009
    ..We used (1)H MRS to investigate brain metabolic differences between patients with SVD and controls and correlated this with cognition...
  53. ncbi Quantification of afferent vessels shows reduced brain vascular density in subjects with leukoaraiosis
    Dixon M Moody
    Department of Radiology, Wake Forest University School of Medicine, Medical Center Blvd, Winston Salem, NC 27157, USA
    Radiology 233:883-90. 2004
    To investigate vessel density changes with increasing age in three areas of the brain and to correlate these changes with leukoaraiosis (LA) on the basis of magnetic resonance (MR) images and location in deep white matter (WM).
  54. ncbi High prevalence of leukoaraiosis in cerebral magnetic resonance images of patients on peritoneal dialysis
    Chan Duck Kim
    Department of Internal Medicine, Kyungpook National University School of Medicine, Daegu, Korea
    Am J Kidney Dis 50:98-107. 2007
    b>Leukoaraiosis is a term used to define the abnormal appearance of subcortical white matter of the brain by means of neuroimaging and is regarded as an intermediate surrogate of stroke...
  55. doi Leukoaraiosis: from an ancient term to an actual marker of poor prognosis
    Leonardo Pantoni
    Stroke 39:1401-3. 2008
  56. pmc Risk factor profile of cerebral small vessel disease and its subtypes
    Usman Khan
    Centre for Clinical Neuroscience, St George s University of London, Cranmer Terrace, London SW17 0RE, UK
    J Neurol Neurosurg Psychiatry 78:702-6. 2007
    ..localised atherosclerotic disease in larger perforating arteries causing larger lacunar infarcts without leukoaraiosis, and diffuse disease in smaller arterioles causing multiple smaller lacunar infarcts with leukoaraiosis...
  57. ncbi Branch occlusive disease: clinical and magnetic resonance angiography findings
    S Ryoo
    Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea
    Neurology 78:888-96. 2012
    ..We evaluated the clinicoradiologic characteristics of patients with branch occlusive disease (BOD)-type intracranial atherosclerotic stroke (ICAS) compared with those of patients with non-BOD-type ICAS or with small artery disease (SAD)...
  58. ncbi Relationship of leukoaraiosis to cognitive decline and cognitive aging
    Elliott D Ross
    Department of Neurology, University of Oklahoma Health Sciences Center, and the VA Medical Center, Oklahoma City, Oklahoma 73104, USA
    Cogn Behav Neurol 18:89-97. 2005
    b>Leukoaraiosis (LA) is a common finding on MRI scans of the elderly. However, its exact relationship to cognitive decline and dementia is in dispute...
  59. ncbi Cerebral leukoaraiosis in patients with stroke or TIA: clinical correlates and 1-year outcome
    S Koton
    From the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    Eur J Neurol 16:218-25. 2009
    Cerebral leukoaraiosis is frequently observed in patients with acute stroke, but its clinical consequences on functional recovery remain incompletely defined...
  60. pmc Changes in white matter as determinant of global functional decline in older independent outpatients: three year follow-up of LADIS (leukoaraiosis and disability) study cohort
    Domenico Inzitari
    Department of Neurological and Psychiatric Sciences, University of Florence, Viale Morgagni 85, 50134 Firenze, Italy
    BMJ 339:b2477. 2009
    ..To assess the impairment in daily living activities in older people with age related changes in white matter according to the severity of these changes...
  61. pmc Leukoaraiosis severity and list-learning in dementia
    Catherine C Price
    Department of Clinical and Health Psychology, University of Florida, PO Box 100165, Gainesville, Florida, 32610, USA
    Clin Neuropsychol 23:944-61. 2009
    In patients with dementia, leukoaraiosis (LA) was hypothesized to result in differential patterns of impairment on a verbal serial list-learning test...
  62. ncbi Development of a neuropsychological battery for the Leukoaraiosis and Disability in the Elderly Study (LADIS): experience and baseline data
    Sofia Madureira
    Servico de Neurologia, Centro de Estudos Egas Moniz, Hospital de Santa Maria, Lisboa, Portugal
    Neuroepidemiology 27:101-16. 2006
    ..The Leukoaraiosis and Disability in the Elderly study (LADIS) involves 11 European centers...
  63. pmc Severity of leukoaraiosis correlates with clinical outcome after ischemic stroke
    E M Arsava
    AA Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Neurology 72:1403-10. 2009
    b>Leukoaraiosis (LA) is closely associated with aging, a major determinant of clinical outcome after ischemic stroke. In this study we sought to identify whether LA, independent of advancing age, affects outcome after acute ischemic stroke.
  64. ncbi Progress of leukoaraiosis is inhibited by correction of platelet hyper-aggregability
    Shigekiyo Fujita
    Department of Neurology and Neurosurgery, Hyogo Brain and Heart Center at Himeji and Institute for Advanced Neurological Medicine and Computed Imaging, Ishikawa Hospital, Himeji, Japan
    Int Psychogeriatr 17:689-98. 2005
    Platelet hyper-aggregability is an important risk factor for leukoaraiosis. In this study we investigated whether aggravation of leukoaraiosis can be controlled by means of long-term correction of platelet hyper-aggregability.
  65. ncbi Plasma homocysteine and severe white matter disease
    B Censori
    Department of Neurology, Ospedali Riuniti, Largo Barozzi 1, I 24100, Bergamo, Italy
    Neurol Sci 28:259-63. 2007
    ..of this study was to assess if high total plasma homocysteine (tHcy) levels are a risk factor for severe leukoaraiosis (LA). This case-control study was done in a primary care neurology ward and included 178 consecutive patients...
  66. ncbi Leukoaraiosis and intracerebral hemorrhage after thrombolysis in acute stroke
    V Palumbo
    Department of Neurological and Psychiatric Sciences, University of Florence, Florence, Italy
    Neurology 68:1020-4. 2007
    To evaluate whether the presence of leukoaraiosis or multiple lacunes is associated with symptomatic intracerebral hemorrhage (ICH) and 90-day outcome after thrombolytic treatment with tissue plasminogen activator (tPA).
  67. ncbi Severity of leukoaraiosis and susceptibility to infarct growth in acute stroke
    Hakan Ay
    A A Martinos Center for Biomedical Imaging and Stroke Service, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, 149 13th Street, Room 2301, Charlestown, MA 02129, USA
    Stroke 39:1409-13. 2008
    b>Leukoaraiosis (LA) is associated with structural and functional vascular changes that may compromise tissue perfusion at the microvascular level...
  68. ncbi Cognitive consequences of multiple lacunes and leukoaraiosis as vascular cognitive impairment in community-dwelling elderly individuals
    Hiroshi Koga
    Center for Emotional and Behavioral Disorders, Hizen psychiatric Center, Saga, Japan
    J Stroke Cerebrovasc Dis 18:32-7. 2009
    ..Silent ischemic lesions in apparently healthy elderly individuals seem to form a distinctive group of people with vascular cognitive impairment without dementia. This group should be the primary target of prevention of vascular dementia...
  69. ncbi A homozygous genetic variant of mitochondrial uncoupling protein 4 affects the occurrence of leukoaraiosis
    Z Szolnoki
    Department of Cerebrovascular Diseases, Pandy Kalman County Hospital, Gyula, Hungary
    Acta Neurol Scand 123:352-7. 2011
    ..protein 4 in the development of vascular demyelinization of the white matter of the brain, referred to as leukoaraiosis (LA)...
  70. ncbi Age, hypertension, and lacunar stroke are the major determinants of the severity of age-related white matter changes. The LADIS (Leukoaraiosis and Disability in the Elderly) Study
    Anna Maria Basile
    Department of Neurological and Psychiatric Sciences, University of Florence, Florence, Italy, and Department of Neurology, Hopital Lariboisiere, Paris, France
    Cerebrovasc Dis 21:315-22. 2006
    ..We sought whether such a trend existed in the association of vascular risk factors or comorbidities with the severity of ARWMC aiming particularly at further elucidating the relative roles of hypertension and stroke in this regard...
  71. ncbi [Cognitive impairment associated to leukoaraiosis: its pathophysiology, clinical manifestations and treatment]
    I Jimenez
    Hospital Clinico Universitario, 15706 Santiago de Compostela, Espana
    Rev Neurol 47:536-44. 2008
    b>Leukoaraiosis is a radiological term which refers to white matter disturbances observed as a hypodensity in computed tomography and hyperintensity in T2-weighted magnetic resonance image...
  72. ncbi Gene-gene and gene-environment interplay represent specific susceptibility for different types of ischaemic stroke and leukoaraiosis
    Zoltan Szolnoki
    Department of Neurology and Neurophysiology, Pandy Kalman County Hospital, Gyula, Hungary
    Curr Med Chem 13:1627-34. 2006
    ..gene-environment interactions concerning the above genetic factors in the evolution of ischaemic stroke and leukoaraiosis. A knowledge of the specific genetic patterns which are associated with a significant risk of ischaemic stroke ..
  73. ncbi Leukoaraiosis is a risk factor for symptomatic intracerebral hemorrhage after thrombolysis for acute stroke
    Tobias Neumann-Haefelin
    Klinik fur Neurologie, ZNN, Klinikum der Goethe Universität, Schleusenweg 2 16, 60528 Frankfurt, Germany
    Stroke 37:2463-6. 2006
    The aim of the study was to evaluate whether leukoaraiosis (LA) is a risk factor for symptomatic intracerebral hemorrhage (sICH) in patients treated with thrombolysis for acute stroke.
  74. ncbi White matter changes contribute to corpus callosum atrophy in the elderly: the LADIS study
    C Ryberg
    Memory Disorders Research Group, Department of Neurology, Copenhagen University Hospital, Copenhagen, Denmark
    AJNR Am J Neuroradiol 29:1498-504. 2008
    ..The aim of this study was to investigate the potential correlation between regional age-related white matter changes (ARWMC) and atrophy of CC in elderly subjects...
  75. ncbi Chemical events behind leukoaraiosis: medicinal chemistry offers new insight into a specific microcirculation disturbance in the brain (a chemical approach to a frequent cerebral phenotype)
    Zoltan Szolnoki
    Department of Neurology and Neurophysiology, Pandy Kalman County Hospital, Gyula, Hungary
    Curr Med Chem 14:1027-36. 2007
    b>Leukoaraiosis (LA), one of the most frequent causes of cognitive disturbances, is presumed to involve vascular demyelinization and cerebral small-vessel diseases...
  76. ncbi Pathomechanism of leukoaraiosis: a molecular bridge between the genetic, biochemical, and clinical processes (a mitochondrial hypothesis)
    Zoltan Szolnoki
    Department of Neurology and Neurophysiology, Pandy Kalman County Hospital, Gyula, Hungary
    Neuromolecular Med 9:21-33. 2007
    ..In neuroimaging terms, it is referred to as leukoaraiosis (LA)...
  77. ncbi Plasma total homocysteine levels are associated with advanced leukoaraiosis but not with asymptomatic microbleeds on T2*-weighted MRI in patients with stroke
    H Naka
    Department of Neurology, Suiseikai Kajikawa Hospital, Showamachi, Hiroshima, Japan
    Eur J Neurol 13:261-5. 2006
    Both leukoaraiosis and asymptomatic microbleeds are associated with small-artery diseases...
  78. ncbi Subclinical vascular disease of the brain in dialysis patients
    Stephen L Seliger
    Am J Kidney Dis 50:8-10. 2007
  79. ncbi The relation between white-matter lesions and cognition
    Leonardo Pantoni
    Department of Neurological and Psychiatric Sciences, University of Florence, Florence, Italy
    Curr Opin Neurol 20:390-7. 2007
    ..To summarize recent findings and developments in the field of the relation between white-matter lesions and cognition...
  80. ncbi Treatment of leukoaraiosis: a futuristic view
    Johanna Helenius
    Department of Neurology, Helsinki University Central Hospital, Helsinki, Finland
    Curr Drug Targets 8:839-45. 2007
    b>Leukoaraiosis (LA or white matter changes of the brain) is a common finding on brain imaging studies in the elderly people...
  81. ncbi White matter changes and late-life depressive symptoms: longitudinal study
    A Teodorczuk
    Institute for Ageing and Health, Newcastle General Hospital, Westgate Road, Newcastle upon Tyne NE4 6BE, UK
    Br J Psychiatry 191:212-7. 2007
    ..Evidence from cross-sectional studies suggests a link between cerebral age-related white matter changes and depressive symptoms in older people, although the temporal association remains unclear...
  82. ncbi Risk for symptomatic intracerebral hemorrhage after thrombolysis assessed by diffusion-weighted magnetic resonance imaging
    Oliver C Singer
    Klinik fur Neurologie, Universitatsklinik, Johann Wolfgang von Goethe Universität, Frankfurt, Germany
    Ann Neurol 63:52-60. 2008
    ..Here, we investigated the relation between pretreatment DWI lesion size and the risk for sICH after thrombolysis...
  83. ncbi Simple versus complex assessment of white matter hyperintensities in relation to physical performance and cognition: the LADIS study
    A A Gouw
    Alzheimer Center, Vrije Universiteit Medical Center, Amsterdam, The Netherlands
    J Neurol 253:1189-96. 2006
    ..The most suitable method to assess WMH in relation to the clinical evaluation of disturbances in these areas has not yet been established...
  84. ncbi The impact of region-specific leukoaraiosis on working memory deficits in dementia
    Melissa Lamar
    MRC Center for Neurodegeneration, Department of Psychology Section of Brain Maturation, Institute of Psychiatry, King s College London, M6 01, P050 De Crespigny Park, London SE5 8AH, United Kingdom
    Neuropsychologia 46:2597-601. 2008
    MRI leukoaraiosis (LA) is less likely to interfere with simple compared to more complex working memory (WM) skills. We hypothesize that LA within the left hemisphere negatively impacts higher-level WM processes in dementia...
  85. ncbi Cerebral blood flow by using pulsed arterial spin-labeling in elderly subjects with white matter hyperintensities
    A J Bastos-Leite
    Image Analysis Center, VU University Medical Center, Amsterdam, The Netherlands
    AJNR Am J Neuroradiol 29:1296-301. 2008
    ..We hypothesized that elderly subjects with diffuse confluent WMH should have lower cerebral blood flow (CBF) measurements than subjects with punctiform or beginning confluent WMH...
  86. ncbi Multimodal MRI in cerebral small vessel disease: its relationship with cognition and sensitivity to change over time
    Arani Nitkunan
    Centre for Clinical Neuroscience, St George s, University of London, Cranmer Terrace, London SW17 0RE, UK
    Stroke 39:1999-2005. 2008
    ..In patients with symptomatic sporadic small vessel disease, we determined which MRI parameters best correlated with cognitive function on cross-sectional analysis and which changed over a period of 1 year...
  87. ncbi Brain parenchymal signal abnormalities associated with developmental venous anomalies: detailed MR imaging assessment
    G M Santucci
    Department of Radiology, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
    AJNR Am J Neuroradiol 29:1317-23. 2008
    ..This study was performed to evaluate the prevalence of brain parenchymal signal-intensity abnormalities subjacent to DVA, correlating with DVA morphology and location...
  88. doi Diabetes increases atrophy and vascular lesions on brain MRI in patients with symptomatic arterial disease
    Audrey M Tiehuis
    Stroke 39:1600-3. 2008
    ..Macrovascular disease has been described as a determinant for brain MRI changes in DM2, but little is known about the involvement of other DM2-related factors...
  89. ncbi Association of gait and balance disorders with age-related white matter changes: the LADIS study
    H Baezner
    Mannheim University Hospital, University of Heidelberg, Department of Neurology, Theodor Kutzer Ufer, D 68135 Mannheim, Germany
    Neurology 70:935-42. 2008
    In the Leukoaraiosis and Disability (LADIS) Study, 11 European centers are evaluating the role of age-related white matter changes (ARWMC) as an independent determinant of the transition to disability in the elderly (65 to 84 years)...
  90. ncbi Study of the positivity of spontaneous and directed diagnosis of leukoaraiosis in the elderly by cranial computerized tomography, and its correlation with cognitive deficit and cardiovascular risk factors
    Mauricio de Miranda Ventura
    Médico do Serviço de Geriatria, Hospital do Servidor Público Estadual Francisco Morato de Oliveira, Sao Paulo, SP, Brasil
    Arq Neuropsiquiatr 65:1134-8. 2007
    To evaluate the prevalence of leukoaraiosis (LA) and its correlation with vascular risk factors and the cognitive performance of elderly patients.
  91. ncbi On the etiology of incident brain lacunes: longitudinal observations from the LADIS study
    Alida A Gouw
    Alzheimer Center, Vrije Universiteit Medical Center, Amsterdam, The Netherlands
    Stroke 39:3083-5. 2008
    ..We investigated regional differences in MRI characteristics and risk factor profiles of incident lacunes over a 3-year period...
  92. ncbi Linking MRI hyperintensities with patterns of neuropsychological impairment: evidence for a threshold effect
    David J Libon
    Department of Neurology, Drexel University College of Medicine, Mail Stop 423, 245 North 15th St, Philadelphia, PA 19102, USA
    Stroke 39:806-13. 2008
    b>Leukoaraiosis (LA) might interrupt intra- and interhemispheric communication and thus induce cognitive impairments and dementia...
  93. ncbi Regional white matter pathology in mild cognitive impairment: differential influence of lesion type on neuropsychological functioning
    Lisa Delano-Wood
    Department of Psychiatry, University of California, San Diego, San Diego, CA 92161, USA
    Stroke 39:794-9. 2008
    ....
  94. ncbi Self-perceived memory impairment and cognitive performance in an elderly independent population with age-related white matter changes
    B Miranda
    Servico de Neurologia, Centro de Estudos Egas Moniz, Hospital de Santa Maria, Lisboa, Portugal
    J Neurol Neurosurg Psychiatry 79:869-73. 2008
    ..To determine whether self-perceived memory impairment is associated with the severity of white matter changes (WMC) and is related to cognitive impairment...
  95. pmc Cortical atrophy and white matter hyperintensities in HIV: the Hawaii Aging with HIV Cohort Study
    Aaron McMurtray
    Department of Medicine, John A Burns School of Medicine, University of Hawaii, Honolulu, HI
    J Stroke Cerebrovasc Dis 17:212-7. 2008
    ....
  96. ncbi Comparison of the Alzheimer's Disease Assessment Scale Cognitive Subscale and the Vascular Dementia Assessment Scale in differentiating elderly individuals with different degrees of white matter changes. The LADIS Study
    Raija Ylikoski
    Memory Research Unit, Department of Neurology, University of Helsinki, Helsinki, Finland
    Dement Geriatr Cogn Disord 24:73-81. 2007
    ..The objective of this study was to compare the results of the two scales among subjects with various degrees of white matter hyperintensities (WMHs)...
  97. ncbi Cerebral white matter hyperintensities on MRI: Current concepts and therapeutic implications
    Bruce Ovbiagele
    Stroke Center and Department of Neurology, University of California at Los Angeles Medical Center, Los Angeles, CA 90095, USA
    Cerebrovasc Dis 22:83-90. 2006
    ..This review provides an overview of current knowledge on vascular WMH, and describes some pharmacological agents that may have a role in mitigating this condition...
  98. ncbi [New evidence in the field of white matter changes]
    Leonardo Pantoni
    Department of Neurological and Psychiatric Sciences, University of Florence, Viale Morgagni 85, 50134 Florence, Italy
    No To Shinkei 58:298-302. 2006
  99. ncbi Leukoaraiosis is associated with functional impairment in older patients with Alzheimer's disease but not vascular dementia
    A Ble
    Department of Clinical and Experimental Medicine, Section of Internal Medicine, Gerontology and Geriatrics University of Ferrara, Via Savonarola No 9, 44100 Ferrara, Italy
    J Nutr Health Aging 10:31-5. 2006
    b>Leukoaraiosis (LA) is a common finding in older persons, and might be associated with reduced cognitive performance, gait abnormalities, and functional impairment...
  100. ncbi Small artery dementia in Japan: radiological differences between CADASIL, leukoaraiosis and Binswanger's disease
    Hidekazu Tomimoto
    Department of Neurology, Graduate School of Medicine, Kyoto University, Sakyo, Japan
    Dement Geriatr Cogn Disord 21:162-9. 2006
    ..These patients included 7 patients from 3 families with CADASIL, 27 nondemented patients with extensive leukoaraiosis (LA) and 24 patients with BD...
  101. pmc Medial temporal lobe atrophy and white matter hyperintensities are associated with mild cognitive deficits in non-disabled elderly people: the LADIS study
    W M van der Flier
    Department of Neurology and Alzheimer Centre, Vrije Universiteit Medical Centre, 1007 MB Amsterdam, The Netherlands
    J Neurol Neurosurg Psychiatry 76:1497-500. 2005
    ..To assess the associations of medial temporal lobe atrophy (MTA) and white matter hyperintensities (WMH) with cognitive function in a large group of independently functioning elderly people...

Research Grants17

  1. Genetics of Microangiopathic Brain Injury
    Stephen T Turner; Fiscal Year: 2010
    ..we conducted genomewide linkage analyses and candidate gene association analyses to identify genes influencing leukoaraiosis, a heritable measure of ischemic brain injury determined by magnetic resonance imaging (MRI) of subcortical ..
  2. Endothelial Mechanism of Vascular Cognitive Impariment (VCI)
    Nabil J Alkayed; Fiscal Year: 2013
    ..SVD is seen radiologically as isolated lacunar infarcts or diffuse ischemic white matter lesions (WML, called leukoaraiosis)...
  3. DEMENTIA AS A RISK FACTOR FOR RECURRENT STROKE
    Joan Moroney; Fiscal Year: 1999
    ..with acute ischemic stroke, and (2) infarct number and volume, cerebral atrophy, lacunar infarction, and leukoaraiosis are independent neuroradiologic predictors of recurrent stroke, adjusting for dementia status...
  4. Mechanisms of Radiation-Induced Cognitive Dysfunction
    William Brown; Fiscal Year: 2008
    ..Such therapeutic intervention studies could potentially be performed in as little as 10 weeks. ..
  5. GENETIC EPIDEMIOLOGY OF RESPONSES TO ANTIHYPERTENSIVES
    Stephen Turner; Fiscal Year: 2006
    ....
  6. Anthipertensive PharmacoGenomics
    Stephen Turner; Fiscal Year: 2006
    ..abstract_text> ..
  7. Genetics of Chronic Kidney Disease
    Stephen T Turner; Fiscal Year: 2010
    ..abstract_text> ..
  8. MECHANISMS OF SECONDARY INJURY IN CEREBRAL HEMORRHAGE
    ALLYSON ZAZULIA; Fiscal Year: 2007
    ..These hypotheses will be tested using sequential PET or MRI studies in 60 patients with acute ICH. ..
  9. Alzheimer's Diagnosis by Real-Time Motion Corrected FMRI
    Clifford Jack; Fiscal Year: 2004
    ..Aim number 4: to assess motion corrected fMRI as a diagnostic test for early Alzheimer's disease. ..
  10. Genes of the CYP450-Derived Eicosanoids Pathway in Subclinical Atherosclerosis
    Myriam Fornage; Fiscal Year: 2010
    ....
  11. REDUCTION OF TRIGLYCERIDES IN WOMEN ON HRT
    Lewis Kuller; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  12. Tryptophan Metabolism, Genes, and Major Depression
    David Steffens; Fiscal Year: 2007
    ..Results from this study will help inform future treatment studies using genetics and metabolomic technology. [unreadable] [unreadable] [unreadable]..
  13. VENOUS SOURCE FOR BLEEDING IN GERMINAL MATRIX HEMORRHAGE
    DIXON MOODY; Fiscal Year: 2002
    ....
  14. Gene-Environment Interactions and Stroke Susceptibility
    Myriam Fornage; Fiscal Year: 2004
    ..We will also identify and characterize DNA variation in a panel of selected stroke-candidate human genes and test whether variation in these genes is associated with risk of developing a stroke in the ARIC sample. ..
  15. A Genome-Wide Association Study of Ischemic Brain Vascular Injury
    Myriam Fornage; Fiscal Year: 2010
    ....
  16. FUNCTIONAL GENOMICS OF ARTERIAL THROMBOSIS
    Myriam Fornage; Fiscal Year: 2004
    ..This collaborative effort is novel for its ability to translate unique animal model research findings to the human condition. ..
  17. Leukoaraiosis in Cerebral Amyloid Angiopathy
    Eric Smith; Fiscal Year: 2007
    ..b>Leukoaraiosis (LA), changes in the cerebral white matter due to chronic ischemia, is known to occur in CAA but the ..