hyperplasia

Summary

Summary: An increase in the number of cells in a tissue or organ without tumor formation. It differs from HYPERTROPHY, which is an increase in bulk without an increase in the number of cells.

Top Publications

  1. pmc Lack of pericytes leads to endothelial hyperplasia and abnormal vascular morphogenesis
    M Hellstrom
    Department of Medical Biochemistry, Goteborg University, SE 405 30 Goteborg, Sweden
    J Cell Biol 153:543-53. 2001
  2. pmc IL-23 stimulates epidermal hyperplasia via TNF and IL-20R2-dependent mechanisms with implications for psoriasis pathogenesis
    Jason R Chan
    Discovery Research, Schering Plough Biopharma Formerly DNAX Research, Inc, Palo Alto, CA 94304, USA
    J Exp Med 203:2577-87. 2006
  3. doi IL-23-mediated psoriasis-like epidermal hyperplasia is dependent on IL-17A
    Heather L Rizzo
    Department of Dermatology, Oregon Health and Science University, Portland, OR 97239, USA
    J Immunol 186:1495-502. 2011
  4. ncbi Bax-deficient mice with lymphoid hyperplasia and male germ cell death
    C M Knudson
    Howard Hughes Medical Institute, Washington University School of Medicine, St Louis, MO 63110, USA
    Science 270:96-9. 1995
  5. pmc A necessary role of miR-221 and miR-222 in vascular smooth muscle cell proliferation and neointimal hyperplasia
    Xiaojun Liu
    RNA and Cardiovascular Research Laboratory, Department of Anesthesiology, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, Newark, NJ 07101, USA
    Circ Res 104:476-87. 2009
  6. pmc Amelioration of epidermal hyperplasia by TNF inhibition is associated with reduced Th17 responses
    Lisa C Zaba
    Laboratory for Investigative Dermatology, The Rockefeller University, New York, NY 10065, USA
    J Exp Med 204:3183-94. 2007
  7. pmc Medulloblastoma can be initiated by deletion of Patched in lineage-restricted progenitors or stem cells
    Zeng Jie Yang
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA
    Cancer Cell 14:135-45. 2008
  8. pmc Pathogenesis of persistent lymphatic vessel hyperplasia in chronic airway inflammation
    Peter Baluk
    Cardiovascular Research Institute, Comprehensive Cancer Center, and Department of Anatomy, UCSF, San Francisco, California 94143, USA
    J Clin Invest 115:247-57. 2005
  9. pmc Dissecting the mechanisms of Notch induced hyperplasia
    Alexandre Djiane
    Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK
    EMBO J 32:60-71. 2013
  10. doi Airway smooth muscle hypertrophy and hyperplasia in asthma
    Alan L James
    Department of Pulmonary Physiology and Sleep Medicine West Australian Sleep Disorders Research Institute, Level 5, G Block, Sir Charles Gairdner Hospital, Hospital Avenue, Nedlands, Western Australia 6009, Australia
    Am J Respir Crit Care Med 185:1058-64. 2012

Detail Information

Publications362 found, 100 shown here

  1. pmc Lack of pericytes leads to endothelial hyperplasia and abnormal vascular morphogenesis
    M Hellstrom
    Department of Medical Biochemistry, Goteborg University, SE 405 30 Goteborg, Sweden
    J Cell Biol 153:543-53. 2001
    ..However, absence of PCs correlates with endothelial hyperplasia, increased capillary diameter, abnormal EC shape and ultrastructure, changed cellular distribution of certain ..
  2. pmc IL-23 stimulates epidermal hyperplasia via TNF and IL-20R2-dependent mechanisms with implications for psoriasis pathogenesis
    Jason R Chan
    Discovery Research, Schering Plough Biopharma Formerly DNAX Research, Inc, Palo Alto, CA 94304, USA
    J Exp Med 203:2577-87. 2006
    ..but IL-17A-independent, cascade of events resulting in erythema, mixed dermal infiltrate, and epidermal hyperplasia associated with parakeratosis...
  3. doi IL-23-mediated psoriasis-like epidermal hyperplasia is dependent on IL-17A
    Heather L Rizzo
    Department of Dermatology, Oregon Health and Science University, Portland, OR 97239, USA
    J Immunol 186:1495-502. 2011
    ..Previous studies showed that IL-22, but not IL-17A, mediates psoriasis-like epidermal hyperplasia following recombinant murine (rm)IL-23 injections into skin...
  4. ncbi Bax-deficient mice with lymphoid hyperplasia and male germ cell death
    C M Knudson
    Howard Hughes Medical Institute, Washington University School of Medicine, St Louis, MO 63110, USA
    Science 270:96-9. 1995
    ..Thymocytes and B cells in this mouse displayed hyperplasia, and Bax-deficient ovaries contained unusual atretic follicles with excess granulosa cells...
  5. pmc A necessary role of miR-221 and miR-222 in vascular smooth muscle cell proliferation and neointimal hyperplasia
    Xiaojun Liu
    RNA and Cardiovascular Research Laboratory, Department of Anesthesiology, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, Newark, NJ 07101, USA
    Circ Res 104:476-87. 2009
    ..The results indicate that miR-221 and miR-222 are novel regulators for VSMC proliferation and neointimal hyperplasia. These findings may also represent promising therapeutic targets in proliferative vascular diseases.
  6. pmc Amelioration of epidermal hyperplasia by TNF inhibition is associated with reduced Th17 responses
    Lisa C Zaba
    Laboratory for Investigative Dermatology, The Rockefeller University, New York, NY 10065, USA
    J Exp Med 204:3183-94. 2007
    ..Th17 cells may be particularly important in driving epidermal activation in psoriatic plaques, whereas Th1 cells must also be eliminated for final disease resolution...
  7. pmc Medulloblastoma can be initiated by deletion of Patched in lineage-restricted progenitors or stem cells
    Zeng Jie Yang
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA
    Cancer Cell 14:135-45. 2008
    ..These studies suggest that medulloblastoma can be initiated in progenitors or stem cells but that Shh-induced tumorigenesis is associated with neuronal lineage commitment...
  8. pmc Pathogenesis of persistent lymphatic vessel hyperplasia in chronic airway inflammation
    Peter Baluk
    Cardiovascular Research Institute, Comprehensive Cancer Center, and Department of Anatomy, UCSF, San Francisco, California 94143, USA
    J Clin Invest 115:247-57. 2005
    ..Correction of defective lymphangiogenesis may benefit the treatment of asthma and other inflammatory airway diseases...
  9. pmc Dissecting the mechanisms of Notch induced hyperplasia
    Alexandre Djiane
    Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK
    EMBO J 32:60-71. 2013
    ..Such disparate outcomes are evident in Drosophila wing discs, where Notch overactivation causes hyperplasia despite having localized inhibitory effects on proliferation...
  10. doi Airway smooth muscle hypertrophy and hyperplasia in asthma
    Alan L James
    Department of Pulmonary Physiology and Sleep Medicine West Australian Sleep Disorders Research Institute, Level 5, G Block, Sir Charles Gairdner Hospital, Hospital Avenue, Nedlands, Western Australia 6009, Australia
    Am J Respir Crit Care Med 185:1058-64. 2012
    Increased thickness of the airway smooth muscle (ASM) layer in asthma may result from hyperplasia or hypertrophy of muscle cells or increased extracellular matrix (ECM).
  11. pmc Pten dose dictates cancer progression in the prostate
    Lloyd C Trotman
    Molecular Biology Program, Memorial Sloan Kettering Cancer Center, Sloan Kettering Institute, New York, New York, USA
    PLoS Biol 1:E59. 2003
    ..Our results provide conclusive genetic support for the notion that PTEN is haploinsufficient in tumor suppression and that its dose is a key determinant in cancer progression...
  12. ncbi A syndrome of multiorgan hyperplasia with features of gigantism, tumorigenesis, and female sterility in p27(Kip1)-deficient mice
    M L Fero
    Department of Basic Sciences, Division of Public Health, Fred Hutchinson Cancer Research Center, Seattle, Washington 98104, USA
    Cell 85:733-44. 1996
    ..All tissues were enlarged and contained more cells, although endocrine abnormalities were not evident. Thymic hyperplasia was associated with increased T lymphocyte proliferation, and T cells showed enhanced IL-2 responsiveness in ..
  13. pmc Regulated proteolysis of Trop2 drives epithelial hyperplasia and stem cell self-renewal via β-catenin signaling
    Tanya Stoyanova
    Department of Microbiology, Immunology, and Molecular Genetics, University of California at Los Angeles, Los Angeles, California 90095, USA
    Genes Dev 26:2271-85. 2012
    ..that loss of β-catenin or Trop2 loss-of-function cleavage mutants abrogates Trop2-driven self-renewal and hyperplasia in the prostate...
  14. pmc DNA methylation changes in atypical adenomatous hyperplasia, adenocarcinoma in situ, and lung adenocarcinoma
    Suhaida A Selamat
    Department of Surgery, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America
    PLoS ONE 6:e21443. 2011
    ..Delineating when abnormal DNA methylation arises may provide insight into the natural history of lung adenocarcinoma and the role that DNA methylation alterations play in tumor formation...
  15. ncbi A randomized comparison of a sirolimus-eluting stent with a standard stent for coronary revascularization
    Marie Claude Morice
    Institut Cardiovasculaire Paris Sud, Massy, France
    N Engl J Med 346:1773-80. 2002
    ..Because sirolimus (rapamycin) inhibits the proliferation of lymphocytes and smooth-muscle cells, we compared a sirolimus-eluting stent with a standard uncoated stent in patients with angina pectoris...
  16. pmc Actomyosin-mediated cellular tension drives increased tissue stiffness and β-catenin activation to induce epidermal hyperplasia and tumor growth
    Michael S Samuel
    Beatson Institute for Cancer Research, Glasgow, UK
    Cancer Cell 19:776-91. 2011
    ..Tumor number, growth, and progression were increased by ROCK activation, while ROCK blockade was inhibitory, implicating actomyosin-mediated cellular tension and consequent collagen deposition as significant tumor promoters...
  17. ncbi Molecular characterization of angiotensin II--induced hypertrophy of cardiac myocytes and hyperplasia of cardiac fibroblasts. Critical role of the AT1 receptor subtype
    J Sadoshima
    Molecular Medicine Division, Beth Israel Hospital, Boston, Mass 02215
    Circ Res 73:413-23. 1993
    ....
  18. ncbi SDF-1alpha/CXCR4 axis is instrumental in neointimal hyperplasia and recruitment of smooth muscle progenitor cells
    Alma Zernecke
    Department of Molecular Cardiovascular Research, University Hospital, Rheinisch Westfalische Technische Hochschule, Aachen, Germany
    Circ Res 96:784-91. 2005
    ..of an antagonist reveals a crucial involvement of local SDF-1alpha and its receptor CXCR4 in neointimal hyperplasia via recruitment of BM-derived SMC progenitors...
  19. pmc Lower blood glucose, hyperglucagonemia, and pancreatic alpha cell hyperplasia in glucagon receptor knockout mice
    R W Gelling
    Department of Diabetes Biology, Pharmacological Research 2, Novo Nordisk AS, DK 2880 Bagsvaerd, Denmark
    Proc Natl Acad Sci U S A 100:1438-43. 2003
    ..mice displayed supraphysiological glucagon levels associated with postnatal enlargement of the pancreas and hyperplasia of islets due predominantly to alpha cell, and to a lesser extent, delta cell proliferation...
  20. doi Synovial fibroblast hyperplasia in rheumatoid arthritis: clinicopathologic correlations and partial reversal by anti-tumor necrosis factor therapy
    Elena Izquierdo
    Servicio de Reumatologia, Hospital 12 de Octubre, Madrid, Spain
    Arthritis Rheum 63:2575-83. 2011
    Synovial fibroblast (SF) hyperplasia contributes to the pathogenesis of rheumatoid arthritis (RA), but quantitative information on this process is scarce...
  21. pmc Hypertrophy and/or Hyperplasia: Dynamics of Adipose Tissue Growth
    Junghyo Jo
    Laboratory of Biological Modeling, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethedsa, Maryland, USA
    PLoS Comput Biol 5:e1000324. 2009
    Adipose tissue grows by two mechanisms: hyperplasia (cell number increase) and hypertrophy (cell size increase). Genetics and diet affect the relative contributions of these two mechanisms to the growth of adipose tissue in obesity...
  22. pmc Splicing factor SRSF6 promotes hyperplasia of sensitized skin
    Mads A Jensen
    1 Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, USA 2
    Nat Struct Mol Biol 21:189-97. 2014
    ..Overexpressing it in transgenic mice induces hyperplasia of sensitized skin and promotes aberrant alternative splicing...
  23. doi Involvement of interleukin-21 in the epidermal hyperplasia of psoriasis
    Roberta Caruso
    Gastroenterology, University Tor Vergata of Rome, Rome, Italy
    Nat Med 15:1013-5. 2009
    ..in the skin of individuals with psoriasis, stimulates human keratinocytes to proliferate and causes epidermal hyperplasia when injected intradermally into mice...
  24. doi IL-21 promotes skin recruitment of CD4(+) cells and drives IFN-γ-dependent epidermal hyperplasia
    Massimiliano Sarra
    Department of Internal Medicine, University of Rome Tor Vergata, 00133 Rome, Italy
    J Immunol 186:5435-42. 2011
    Psoriasis is a chronic inflammatory disorder of the skin characterized by epidermal hyperplasia and infiltration of leukocytes into the dermis and epidermis...
  25. ncbi Cellular, molecular and immunological mechanisms in the pathophysiology of vein graft intimal hyperplasia
    Amit K Mitra
    Department of Biomedical Sciences, Creighton University School of Medicine, Omaha, NE 68178, USA
    Immunol Cell Biol 84:115-24. 2006
    ..The events leading to intimal hyperplasia (IH) formation involve numerous cellular and molecular components...
  26. pmc Pigment epithelium-derived factor inhibits neointimal hyperplasia after vascular injury by blocking NADPH oxidase-mediated reactive oxygen species generation
    Kazuo Nakamura
    Department of Medicine, Division of Cardio Vascular Medicine, Kurume University School of Medicine, 67 Asahi Machi, Kurume 830 0011, Japan
    Am J Pathol 170:2159-70. 2007
    ..Our present study suggests that substitution of PEDF may be a novel therapeutic strategy for restenosis after balloon angioplasty...
  27. pmc Glucose-dependent insulinotropic peptide receptor overexpression in adrenocortical hyperplasia in MEN1 syndrome without loss of heterozygosity at the 11q13 locus
    Marcia Helena Soares Costa
    Unidade de Suprarrenal, do Hospital das Clinicas da Faculdade de Medicina da Universidade de São Paulo, SP, Brasil
    Clinics (Sao Paulo) 66:529-33. 2011
    ..However, to our knowledge, the status of glucose-dependent insulinotropic peptide receptor expression in adrenocortical lesions in MEN1 has not been previously investigated...
  28. doi Effect of total saponins of "panax notoginseng root" on aortic intimal hyperplasia and the expressions of cell cycle protein and extracellular matrix in rats
    Lu Wu
    The Second Affiliated Traditional and Western Medicine Hospital of Hunan University of Traditional Chinese Medicine, Liuyang, Changsha, Hunan, China
    Phytomedicine 17:233-40. 2010
    the effect of total saponins of "panax notoginseng root" on aortic intimal hyperplasia and the expressions of cell cycle protein and extracellular matrix in rats
  29. doi Upregulation of aquaporin-3 is involved in keratinocyte proliferation and epidermal hyperplasia
    Kyoko Nakahigashi
    Department of Dermatology, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    J Invest Dermatol 131:865-73. 2011
    ..However, the involvement of AQP3 in epidermal hyperplasia in skin diseases, such as atopic dermatitis (AD), is unknown...
  30. doi Notch3 null mutation in mice causes muscle hyperplasia by repetitive muscle regeneration
    Takeo Kitamoto
    Department of Bioscience, Kitasato University School of Science, Sagamihara, Kanagawa, Japan
    Stem Cells 28:2205-16. 2010
    ..Because overexpression of Notch3 activated the expression of Nrarp, a negative feedback regulator of Notch signaling, Notch3 might act as a Notch1 repressor by activating Nrarp...
  31. pmc Mutant KRAS promotes hyperplasia and alters differentiation in the colon epithelium but does not expand the presumptive stem cell pool
    Ying Feng
    Division of Molecular Medicine and Genetics, Departments of Internal Medicine, Human Genetics, and Pathology, and the Cancer Center, University of Michigan Medical School, Ann Arbor, Michigan, USA
    Gastroenterology 141:1003-1013.e1-10. 2011
    ..We investigated the reasons why HPPs with KRAS mutations lack malignant potential and compared the effects of Kras/KRAS activation with those of Apc/APC inactivation, which promotes adenoma formation...
  32. doi Constitutive beta-catenin activation induces adrenal hyperplasia and promotes adrenal cancer development
    Annabel Berthon
    Clermont Universite, Universite Blaise Pascal, GReD, BP 10448, F 63000 Clermont Ferrand, France
    Hum Mol Genet 19:1561-76. 2010
    ..cortex of transgenic mice resulted in progressive steroidogenic and undifferentiated spindle-shaped cells hyperplasia as well as dysplasia of the cortex and medulla...
  33. pmc Diarrhoea-predominant IBS patients show mast cell activation and hyperplasia in the jejunum
    Mar Guilarte
    Department of Medicine, Hospital Universitari General Vall d Hebron, 08035 Barcelona, Spain
    Gut 56:203-9. 2007
    ..Although upper gut symptoms are common, mast cells have not been thoroughly evaluated in proximal gut in IBS patients...
  34. pmc Upregulated TRPC1 channel in vascular injury in vivo and its role in human neointimal hyperplasia
    B Kumar
    Institute of Membrane and Systems Biology, University of Leeds, United Kingdom
    Circ Res 98:557-63. 2006
    ..factor is the switch in smooth muscle cells to an invasive and proliferative mode, leading to neointimal hyperplasia. Here we reveal the importance to this process of TRPC1, a homolog of Drosophila transient receptor potential...
  35. pmc Glucokinase and IRS-2 are required for compensatory beta cell hyperplasia in response to high-fat diet-induced insulin resistance
    Yasuo Terauchi
    Department of Metabolic Diseases, Graduate School of Medicine, University of Tokyo, Hongo, Tokyo, Japan
    J Clin Invest 117:246-57. 2007
    ..When fed a high-fat (HF) diet, wild-type mice showed marked beta cell hyperplasia, whereas Gck(+/-) mice demonstrated decreased beta cell replication and insufficient beta cell hyperplasia ..
  36. pmc PDX-1 haploinsufficiency limits the compensatory islet hyperplasia that occurs in response to insulin resistance
    Rohit N Kulkarni
    Research Division, Joslin Diabetes Center and Department of Medicine, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Clin Invest 114:828-36. 2004
    Inadequate compensatory beta cell hyperplasia in insulin-resistant states triggers the development of overt diabetes. The mechanisms that underlie this crucial adaptive response are not fully defined...
  37. ncbi VEGF-A, VEGF-D and VEGF-D(DeltaNDeltaC) induced intimal hyperplasia in carotid arteries
    S Bhardwaj
    University of Kuopio, Kuopio, Finland
    Eur J Clin Invest 35:669-76. 2005
    The role of vascular endothelial growth factors (VEGFs) in intimal hyperplasia and atherogenesis remains unknown...
  38. ncbi Overexpression of insulin-like growth factor-II in transgenic mice is associated with pancreatic islet cell hyperplasia
    J Petrik
    Lawson Research Institute, St Joseph s Health Centre, London, Ontario, Canada
    Endocrinology 140:2353-63. 1999
    ..The area of islets immunopositive for IGF binding protein-2 was unaltered. Despite the presence of islet hyperplasia, circulating insulin levels and serum glucose levels were not significantly different between transgenic and ..
  39. ncbi Relative importance of enterochromaffin cell hyperplasia, anxiety, and depression in postinfectious IBS
    Simon P Dunlop
    Wolfson Digestive Diseases Centre, University Hospital, Nottingham, England
    Gastroenterology 125:1651-9. 2003
    ..Our aim was to prospectively determine the relative importance of both psychological and histologic factors in the development of PI-IBS after Campylobacter infection...
  40. pmc Sustained TL1A expression modulates effector and regulatory T-cell responses and drives intestinal goblet cell hyperplasia
    V Y Taraban
    Cancer Sciences Division, School of Medicine, University of Southampton, Southampton General Hospital, Southampton, UK
    Mucosal Immunol 4:186-96. 2011
    ..TL1A transgenic mice developed striking goblet cell hyperplasia in the ileum that was associated with elevated interleukin (IL)-13 levels in the small intestine...
  41. doi Expression of IL-19 and its receptors in RA: potential role for synovial hyperplasia formation
    N Sakurai
    Department of Medicine and Clinical Science, Gunma University Graduate School of Medicine, 3 39 15 Showa, Maebashi, Gunma 371 8511, Japan
    Rheumatology (Oxford) 47:815-20. 2008
    ..IL-19 is a novel cytokine of the IL-10 family. In this study, we sought to examine whether IL-19 plays a role in the pathogenesis of RA...
  42. ncbi Morphologic reappraisal of serrated colorectal polyps
    Emina Torlakovic
    Department of Pathology, The Norwegian Radium Hospital, University of Oslo, Norway
    Am J Surg Pathol 27:65-81. 2003
    ....
  43. ncbi PIK3CA and PTEN mutations in uterine endometrioid carcinoma and complex atypical hyperplasia
    Monica Prasad Hayes
    Department of Pathology and Laboratory Medicine, Weill Medical College of Cornell University, New York, NY 10021, USA
    Clin Cancer Res 12:5932-5. 2006
    ..PTEN mutations are also common in complex atypical hyperplasia (CAH), the precursor lesion of UEC. The status of PIK3CA has not yet been explored in CAH...
  44. ncbi IL-9-deficient mice establish fundamental roles for IL-9 in pulmonary mastocytosis and goblet cell hyperplasia but not T cell development
    J M Townsend
    MRC Laboratory of Molecular Biology, Cambridge, United Kingdom
    Immunity 13:573-83. 2000
    ..have demonstrated a distinct requirement for IL-9 in the rapid and robust generation of pulmonary goblet cell hyperplasia and mastocytosis in response to lung challenge...
  45. ncbi Efficacy and safety of edifoligide, an E2F transcription factor decoy, for prevention of vein graft failure following coronary artery bypass graft surgery: PREVENT IV: a randomized controlled trial
    John H Alexander
    Duke University Medical Center, Duke Clinical Research Institute, Durham, NC 27715, USA
    JAMA 294:2446-54. 2005
    ..Progressive neointimal hyperplasia, however, contributes to considerable vein graft failure...
  46. doi Mice deficient for glucagon gene-derived peptides display normoglycemia and hyperplasia of islet {alpha}-cells but not of intestinal L-cells
    Yoshitaka Hayashi
    Department of Genetics, Research Institute of Environmental Medicine, Nagoya University, Japan
    Mol Endocrinol 23:1990-9. 2009
    ..The Gcg(gfp/gfp) postnatally developed hyperplasia of islet alpha-cells, whereas the population of intestinal L-cells was not increased...
  47. pmc Insulin receptors in beta-cells are critical for islet compensatory growth response to insulin resistance
    Terumasa Okada
    Research Division, Joslin Diabetes Center and Department of Medicine, Harvard Medical School, Boston, MA 02215, USA
    Proc Natl Acad Sci U S A 104:8977-82. 2007
    ..in beta-cells (beta IRKO/LIRKO), exhibited severe glucose intolerance but failed to develop compensatory islet hyperplasia, together leading to early death...
  48. pmc Wnt signaling activation and mammary gland hyperplasia in MMTV-LRP6 transgenic mice: implication for breast cancer tumorigenesis
    J Zhang
    Department of Pediatrics, Washington University School of Medicine, St Louis, MO 63110, USA
    Oncogene 29:539-49. 2010
    ..More importantly, mammary glands from virgin MMTV-LRP6 mice exhibit significant hyperplasia, a precursor to breast cancer, when compared with wild-type littermate controls...
  49. doi Proinflammatory cytokines induce bronchial hyperplasia and squamous metaplasia in smokers: implications for chronic obstructive pulmonary disease therapy
    Michael Herfs
    Laboratory of Experimental Pathology, GIGA Cancer, University of Liege, Belgium
    Am J Respir Cell Mol Biol 47:67-79. 2012
    ..proinflammatory cytokine up-regulation in the development and treatment of tracheobronchial epithelial hyperplasia and squamous metaplasia...
  50. pmc Beta-Cell hyperplasia induced by hepatic insulin resistance: role of a liver-pancreas endocrine axis through insulin receptor A isoform
    Oscar Escribano
    Department of Biochemistry and Molecular Biology, Faculty of Pharmacy, Complutense University of Madrid, Madrid, Spain
    Diabetes 58:820-8. 2009
    ..To directly address the effects of hepatic insulin resistance in adult animals, we developed an inducible liver-specific insulin receptor knockout mouse (iLIRKO)...
  51. pmc Knockout of secretin receptor reduces large cholangiocyte hyperplasia in mice with extrahepatic cholestasis induced by bile duct ligation
    Shannon Glaser
    Scott and White Digestive Disease Research Center, College of Medicine, Temple, TX, USA
    Hepatology 52:204-14. 2010
    ..Stable knockdown of SR expression reduced basal cholangiocyte proliferation. SR is an important trophic regulator sustaining biliary growth...
  52. pmc Inadequate lung development and bronchial hyperplasia in mice with a targeted deletion in the Dutt1/Robo1 gene
    J Xian
    Medical Research Council MRC Molecular Oncology Group, Department of Oncology, University of Cambridge, MRC Centre, United Kingdom
    Proc Natl Acad Sci U S A 98:15062-6. 2001
    ..Survivors acquire extensive bronchial epithelial abnormalities including hyperplasia, providing evidence of a functional relationship between a 3p gene and the development of bronchial ..
  53. doi Sulfasalazine induces haem oxygenase-1 via ROS-dependent Nrf2 signalling, leading to control of neointimal hyperplasia
    Ju Young Kim
    National Research Laboratory on Cardiovascular Stem Cell, Seoul National University, College of Medicine, Seoul, Korea
    Cardiovasc Res 82:550-60. 2009
    ..smooth muscle cells (VSMCs), is one of the major pathophysiological mechanisms associated with neointimal hyperplasia following vascular injury...
  54. ncbi Naringenin inhibits angiotensin II-induced vascular smooth muscle cells proliferation and migration and decreases neointimal hyperplasia in balloon injured rat carotid arteries through suppressing oxidative stress
    Changwu Xu
    Department of Cardiology, Renmin Hospital of Wuhan University Cardiovascular Research Institute of Wuhan University
    Biol Pharm Bull 36:1549-55. 2013
    ..naringenin could inhibit angiotensin II-induced VSMCs proliferation and migration and decrease neointimal hyperplasia in balloon injured rat carotid arteries...
  55. ncbi Chronic stress induces adrenal hyperplasia and hypertrophy in a subregion-specific manner
    Yvonne M Ulrich-Lai
    Department of Psychiatry, University of Cincinnati, Cincinnati, Ohio 45237 0506, USA
    Am J Physiol Endocrinol Metab 291:E965-73. 2006
    ..exposure commonly increases adrenal weight, but it is not known to what extent this growth is due to cellular hyperplasia or hypertrophy and whether it is subregion specific...
  56. pmc TBX3 over-expression causes mammary gland hyperplasia and increases mammary stem-like cells in an inducible transgenic mouse model
    Jing Liu
    Department of Pediatrics, Division of Human Genetics, University of California, Irvine, USA
    BMC Dev Biol 11:65. 2011
    ..Although many studies have shown that a dysregulation of TBX3 expression may contribute to cancer progression, no direct evidence shows TBX3 causes breast cancer...
  57. ncbi Adventitial remodeling with increased matrix metalloproteinase-2 activity in a porcine arteriovenous polytetrafluoroethylene grafts
    Sanjay Misra
    Department of Radiology, Division of Vascular Surgery, Division of Cardiovascular Diseases and Internal Medicine, Mayo Clinic, Rochester, MN 55905, USA
    Kidney Int 68:2890-900. 2005
    ....
  58. doi Baicalein attenuates intimal hyperplasia after rat carotid balloon injury through arresting cell-cycle progression and inhibiting ERK, Akt, and NF-kappaB activity in vascular smooth-muscle cells
    Chieh Yu Peng
    Pharmacological Institute, College of Medicine, National Taiwan University, Taipei, Taiwan
    Naunyn Schmiedebergs Arch Pharmacol 378:579-88. 2008
    ..baicalein-mediated inhibitory effects on vascular smooth-muscle cell (VSMC) proliferation and intimal hyperplasia by balloon angioplasty in the rat...
  59. ncbi Cellular and morphological changes during neointimal hyperplasia development in a porcine arteriovenous graft model
    Li Li
    Department of Medicine, University of Utah, Salt Lake City, UT 84112, USA
    Nephrol Dial Transplant 22:3139-46. 2007
    Implantation of a haemodialysis arteriovenous graft is often followed by the development of neointimal hyperplasia (NH) at the venous anastomosis. The nature of the proliferating cells in these lesions is not well understood...
  60. pmc Cigarette smoke suppresses Bik to cause epithelial cell hyperplasia and mucous cell metaplasia
    Yohannes A Mebratu
    Lovelace Respiratory Research Institute, Albuquerque, NM 87108, USA
    Am J Respir Crit Care Med 183:1531-8. 2011
    ..Because the Bcl-2 family of proteins is crucial for airway epithelial homeostasis, identifying the players that reduce cigarette smoke (CS)-induced mucous cell metaplasia can help to develop effective therapies...
  61. doi Salvianolic acid B inhibits low-density lipoprotein oxidation and neointimal hyperplasia in endothelium-denuded hypercholesterolaemic rabbits
    Tung Lin Yang
    Department of Life Sciences, National Central University, Taoyuan, Taiwan
    J Sci Food Agric 91:134-41. 2011
    ..In this study the in vitro and in vivo inhibitory effects of Sal B on oxidative stress were determined...
  62. pmc Osteopontin mediates Citrobacter rodentium-induced colonic epithelial cell hyperplasia and attaching-effacing lesions
    Eytan Wine
    Pediatric Gastroenterology, University of Alberta, Edmonton, Alberta, Canada
    Am J Pathol 177:1320-32. 2010
    ..rodentium infection of wild-type mice. Furthermore, colonic epithelial cell hyperplasia, the hallmark of C...
  63. doi G1P3, an interferon- and estrogen-induced survival protein contributes to hyperplasia, tamoxifen resistance and poor outcomes in breast cancer
    V Cheriyath
    Translational Hematology and Oncology Research, Taussig Cancer Institute, The Cleveland Clinic, Cleveland, OH 44195, USA
    Oncogene 31:2222-36. 2012
    ..In accord with its overexpression in early stages of breast cancer (hyperplasia and ductal carcinoma in situ), in morphogenesis assays G1P3 enhanced the survival of MCF10A acinar luminal ..
  64. pmc Functional cross-talk between beta-catenin and NFkappaB signaling pathways in colonic crypts of mice in response to progastrin
    Shahid Umar
    Department of Internal Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104, USA
    J Biol Chem 284:22274-84. 2009
    ..NEMO peptide significantly blocked increases in cyclin D1 expression, thereby, abrogating hyperplasia of proximal crypts...
  65. doi TGF-beta signaling may play a role in the development of goblet cell hyperplasia in a mouse model of allergic rhinitis
    Yuhui Ouyang
    Department of Immunology, University of Yamanashi Faculty of Medicine, Yamanashi, Japan
    Allergol Int 59:313-9. 2010
    ..The objective of this study is to investigate whether TGF-beta signaling is activated in allergic rhinitis and plays a role in the pathophysiology of allergic rhinitis...
  66. pmc Homozygous P86S mutation of the human glucagon receptor is associated with hyperglucagonemia, alpha cell hyperplasia, and islet cell tumor
    Cuiqi Zhou
    Division of Endocrinology, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    Pancreas 38:941-6. 2009
    The goal of the study was to investigate the genetic and molecular basis of a novel syndrome of marked hyperglucagonemia and pancreatic alpha cell hyperplasia without glucagonoma syndrome.
  67. doi Non-autonomous crosstalk between the Jak/Stat and Egfr pathways mediates Apc1-driven intestinal stem cell hyperplasia in the Drosophila adult midgut
    Julia B Cordero
    Wnt Signaling and Colorectal Cancer Group, The Beatson Institute for Cancer Research, Garscube Estate, Switchback Road, Glasgow G61 1BD, UK
    Development 139:4524-35. 2012
    ..use the adult Drosophila midgut as a model system to investigate the molecular events that mediate intestinal hyperplasia following loss of Apc in the intestine...
  68. ncbi Keratoacanthoma: hyperplasia, benign neoplasm, or a type of squamous cell carcinoma?
    Joshua C Mandrell
    St Johns Mercy Medical Center, St Louis, Missouri, USA
    Semin Diagn Pathol 26:150-63. 2009
    ..We believe the evidence supports that keratoacanthomas are benign squamous proliferations. The diagnosis can be made with confidence in appropriate biopsies and using well established clinicopathological criteria...
  69. doi Familial neuroendocrine cell hyperplasia of infancy
    J Popler
    Department of Pediatrics, University of Colorado Denver, Aurora, CO 80045, USA
    Pediatr Pulmonol 45:749-55. 2010
    Neuroendocrine cell hyperplasia of infancy (NEHI) is a recently described children's interstitial lung disease (chILD) disorder of unknown etiology. It manifests clinically with tachypnea, retractions, hypoxemia, and crackles...
  70. ncbi Cross talk between endothelial and smooth muscle cells in pulmonary hypertension: critical role for serotonin-induced smooth muscle hyperplasia
    Saadia Eddahibi
    INSERM U651, Departement de Physiologie, Hôpital H Mondor, AP HP, Creteil, France
    Circulation 113:1857-64. 2006
    The mechanism of pulmonary artery smooth muscle cell (PA-SMC) hyperplasia in idiopathic pulmonary artery hypertension (iPH) may involve both an inherent characteristic of PA-SMCs and abnormal control by external stimuli...
  71. ncbi A mouse model of vascular injury that induces rapid onset of medial cell apoptosis followed by reproducible neointimal hyperplasia
    M Sata
    Department of Cardiovascular Medicine, University of Tokyo, Tokyo, 113 8655, Japan
    J Mol Cell Cardiol 32:2097-104. 2000
    ..circumference of the external elastic lamina remained enlarged, the lumen was gradually narrowed by neointimal hyperplasia composed of smooth muscle cells...
  72. ncbi Serum chromogranin A as a screening test for gastric enterochromaffin-like cell hyperplasia during acid-suppressive therapy
    S Sanduleanu
    Department of Gastroenterology Hepatology, University Hospital Maastricht, Maastricht, The Netherlands
    Eur J Clin Invest 31:802-11. 2001
    ..Serum chromogranin A (CgA), a marker of neuroendocrine neoplasia, increases during profound gastric acid inhibition, possibly reflecting the trophic effect of gastrin on the enterochromaffin-like (ECL) cells...
  73. pmc Liver-derived systemic factors drive β cell hyperplasia in insulin-resistant states
    Abdelfattah El Ouaamari
    Section of Islet Cell Biology and Regenerative Medicine, Joslin Diabetes Center and Harvard Medical School, Boston, MA 02115, USA
    Cell Rep 3:401-10. 2013
    ..we used the liver-specific insulin receptor knockout (LIRKO) mouse, a unique model that exhibits dramatic islet hyperplasia. Using complementary in vivo parabiosis and transplantation assays, as well as in vitro islet culture ..
  74. doi Pseudomonas aeruginosa pyocyanin causes airway goblet cell hyperplasia and metaplasia and mucus hypersecretion by inactivating the transcriptional factor FoxA2
    Yonghua Hao
    Department of Pathobiology, University of Illinois at Urbana Champaign, Urbana, IL, USA
    Cell Microbiol 14:401-15. 2012
    ..PCN is required for chronic PA lung infection in mice, and that chronic instillation of PCN induces goblet cell hyperplasia (GCH), pulmonary fibrosis, emphysema and influx of immune cells in mouse airways...
  75. ncbi The role of nitric oxide in the pathophysiology of intimal hyperplasia
    Sadaf S Ahanchi
    Division of Vascular Surgery, Northwestern University, Chicago, IL 60611, USA
    J Vasc Surg 45:A64-73. 2007
    ..Next, we turn our attention to describing the arterial injury response of neointimal hyperplasia, and we review the role of NO in the pathophysiology of neointimal hyperplasia...
  76. pmc Papillary tubal hyperplasia: the putative precursor of ovarian atypical proliferative (borderline) serous tumors, noninvasive implants, and endosalpingiosis
    Robert J Kurman
    Department of Pathology, The Johns Hopkins Hospital, Baltimore, MD, USA
    Am J Surg Pathol 35:1605-14. 2011
    ..We have identified a lesion, designated "papillary tubal hyperplasia (PTH)," characterized by small rounded clusters of tubal epithelial cells and small papillae, with or without ..
  77. pmc Lithium chloride inhibits vascular smooth muscle cell proliferation and migration and alleviates injury-induced neointimal hyperplasia via induction of PGC-1α
    Zhuyao Wang
    Jiangsu Key Laboratory for Molecular and Medical Biotechnology and College of Life Sciences, Nanjing Normal University, Nanjing, Jiangsu, China
    PLoS ONE 8:e55471. 2013
    ..in vivo administration of LiCl alleviated the pathophysiological changes in balloon injury-induced neointima hyperplasia. More importantly, knockdown of PGC-1α by siRNA significantly attenuated the beneficial effects of LiCl on ..
  78. ncbi Novel TNF-α receptor 1 antagonist treatment attenuates arterial inflammation and intimal hyperplasia in mice
    Manabu Kitagaki
    Medical Engineering, National Defense Medical College, Saitama, Japan
    J Atheroscler Thromb 19:36-46. 2012
    ..however it remains undetermined whether a selective TNFR1 antagonist inhibits arterial inflammation and intimal hyperplasia. This study aimed to determine the effect and mechanism of a novel TNFR1 antagonist in the suppression of ..
  79. doi Inhibitory effect of fenofibrate on neointima hyperplasia via G(0)/G(1) arrest of cell proliferation
    Jung Jin Lee
    Department of Pharmacology, College of Pharmacy and Graduate School of New Drug Discovery and Development, Chungnam National University, Daejeon 305 764, Republic of Korea
    Eur J Pharmacol 650:342-9. 2011
    ..The present study was designed to investigate the effects of fenofibrate on the neointimal hyperplasia and its possible molecular mechanism...
  80. doi Randomized comparison of 6- versus 24-month clopidogrel therapy after balancing anti-intimal hyperplasia stent potency in all-comer patients undergoing percutaneous coronary intervention Design and rationale for the PROlonging Dual-antiplatelet treatment
    Marco Valgimigli
    Cardiology Department, University of Ferrara, Ferrara, Italy
    Am Heart J 160:804-11. 2010
    ....
  81. pmc Estrogen receptor-beta activated apoptosis in benign hyperplasia and cancer of the prostate is androgen independent and TNFalpha mediated
    Stephen J McPherson
    Prostate and Breast Cancer Research Group, Department of Anatomy and Developmental Biology, Monash University, Clayton, Victoria 3800, Australia
    Proc Natl Acad Sci U S A 107:3123-8. 2010
    Prostate cancer (PCa) and benign prostatic hyperplasia (BPH) are androgen-dependent diseases commonly treated by inhibiting androgen action...
  82. doi A mouse model of airway disease: oncostatin M-induced pulmonary eosinophilia, goblet cell hyperplasia, and airway hyperresponsiveness are STAT6 dependent, and interstitial pulmonary fibrosis is STAT6 independent
    Dominik K Fritz
    Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada
    J Immunol 186:1107-18. 2011
    ..AdmOSM also induced pronounced pulmonary remodeling characterized by goblet cell hyperplasia and parenchymal interstitial fibrosis...
  83. pmc Angiotensin II induces a region-specific hyperplasia of the ascending aorta through regulation of inhibitor of differentiation 3
    A Phillip Owens
    Saha Cardiovascular Research Center, University of Kentucky, Lexington, KY 40536 0509, USA
    Circ Res 106:611-9. 2010
    ..Angiotensin II (Ang II) has diverse effects on smooth muscle cells (SMCs). The diversity of effects may relate to the regional location of this cell type...
  84. pmc Paternal mutation of the sulfonylurea receptor (SUR1) gene and maternal loss of 11p15 imprinted genes lead to persistent hyperinsulinism in focal adenomatous hyperplasia
    V Verkarre
    INSERM UR 383, Hopital Necker Enfants Malades, University Paris V, 75743 Paris Cedex 15, France
    J Clin Invest 102:1286-91. 1998
    ..From a morphological standpoint, there are two types of histopathological lesions, a focal adenomatous hyperplasia of islet cells of the pancreas in approximately 30% of operated sporadic cases, and a diffuse form...
  85. ncbi Effects of balloon injury on neointimal hyperplasia in streptozotocin-induced diabetes and in hyperinsulinemic nondiabetic pancreatic islet-transplanted rats
    C Indolfi
    Division of Cardiology, University Federico II, and the National Cancer Institute, Naples, Italy
    Circulation 103:2980-6. 2001
    The mechanisms of increased neointimal hyperplasia after coronary interventions in diabetic patients are still unknown.
  86. ncbi IKKbeta-dependent NF-kappaB pathway controls vascular inflammation and intimal hyperplasia
    De xiu Bu
    Cardiovascular Research Unit L8 03, Center for Molecular Medicine, Karolinska Institute, Stockholm, Sweden
    FASEB J 19:1293-5. 2005
    ..Collectively, these findings show that the IKKbeta-mediated late-phase NF-kappaB activation contributes to intimal hyperplasia and the accompanied vascular inflammatory responses.
  87. ncbi Fludarabine prevents smooth muscle proliferation in vitro and neointimal hyperplasia in vivo through specific inhibition of STAT-1 activation
    Daniele Torella
    Laboratory of Molecular and Cellular Cardiology, Magna Graecia University, Catanzaro, Italy
    Am J Physiol Heart Circ Physiol 292:H2935-43. 2007
    ..after balloon angioplasty in a dose-dependent manner, and fludarabine-eluting stents reduced neointimal hyperplasia by approximately 50%...
  88. ncbi Serum amyloid A binding to formyl peptide receptor-like 1 induces synovial hyperplasia and angiogenesis
    Mi Sook Lee
    Division of Molecular Life Sciences, Pohang University of Science and Technology, Pohang, Korea
    J Immunol 177:5585-94. 2006
    ..Although SAA has been used as an indicator for a variety of inflammatory diseases, the role of SAA in synovial hyperplasia and proliferation of endothelial cells, a pathological hallmark of rheumatoid arthritis (RA), has yet to be ..
  89. pmc Defining the origins of Ras/p53-mediated squamous cell carcinoma
    Andrew C White
    Department of Molecular, Cell, and Developmental Biology, David Geffen School of Medicine, and Jonsson Comprehensive Cancer Center, University of California, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 108:7425-30. 2011
    ..in situ, we highlight the phenotypes of cancer progression from the hair follicle SC niche, including hyperplasia, epithelial to mesenchymal transition, and SCC formation...
  90. ncbi Biliverdin administration prevents the formation of intimal hyperplasia induced by vascular injury
    Atsunori Nakao
    Thomas E Starzl Transplantation Institute, University of Pittsburgh, Pittsburgh, PA, USA
    Circulation 112:587-91. 2005
    ..Their success is limited by the development of intimal hyperplasia (IH)...
  91. pmc Advanced glycation end product receptor-1 transgenic mice are resistant to inflammation, oxidative stress, and post-injury intimal hyperplasia
    Massimo Torreggiani
    Division of Experimental Diabetes and Aging, Department of Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA
    Am J Pathol 175:1722-32. 2009
    ..After wire-injury, intimal lesions in AGER1-tg mice were small, whereas wild-type mice had diffuse intimal hyperplasia, a high intima/media ratio, and inflammatory cell infiltrates...
  92. ncbi Stent-based delivery of sirolimus reduces neointimal formation in a porcine coronary model
    T Suzuki
    Stanford University Medical Center, Stanford, California, USA
    Circulation 104:1188-93. 2001
    ..delivery of sirolimus (SRL) alone or in combination with dexamethasone (DEX) to reduce in-stent neointimal hyperplasia. SRL is a potent immunosuppressive agent that inhibits SMC proliferation by blocking cell cycle progression...
  93. pmc CD4+ T cell-mediated immunological control of enterochromaffin cell hyperplasia and 5-hydroxytryptamine production in enteric infection
    Huaqing Wang
    Intestinal Diseases Research Program, Department of Medicine, Room 3N5D, Health Science Centre, McMaster University, 1200 Main Street West, Hamilton, Ontario, Canada L8N 3Z5
    Gut 56:949-57. 2007
    ..5-HT has been implicated in the pathophysiology of several GI disorders, but the mechanisms regulating 5-HT production in the gut are unknown...
  94. ncbi VavP-Bcl2 transgenic mice develop follicular lymphoma preceded by germinal center hyperplasia
    Alexander Egle
    Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia
    Blood 103:2276-83. 2004
    ..The germinal center hyperplasia required CD4 T cells, because it could be abolished by anti-CD4 antibody in vivo...
  95. ncbi Congenital disorder of glycosylation id presenting with hyperinsulinemic hypoglycemia and islet cell hyperplasia
    Liangwu Sun
    The Burnham Institute, Program for Glycobiology and Carbohydrate Chemistry, 10901 North Torrey Pines Road, La Jolla, California 92037, USA
    J Clin Endocrinol Metab 90:4371-5. 2005
    ..Inborn errors in protein glycosylation, such as the congenital disorders of glycosylation (CDGs), generate multifaceted syndromes that impair many organ systems. We here report the diagnosis of the third known patient with CDG-Id...
  96. pmc Absence of caveolin-1 sensitizes mouse skin to carcinogen-induced epidermal hyperplasia and tumor formation
    Franco Capozza
    Department of Molecular Pharmacology and The Albert Einstein Cancer Center, Albert Einstein College of Medicine, Bronx, New York, USA
    Am J Pathol 162:2029-39. 2003
    ..Moreover, before the development of tumors, DMBA-treatment induced severe epidermal hyperplasia in Cav-1 null mice...
  97. pmc Ablation of the glucagon receptor gene increases fetal lethality and produces alterations in islet development and maturation
    Patricia M Vuguin
    Division of Pediatric Endocrinology, Children s Hospital at Montefiore Medical Center, 111 East 210th Street, Bronx, New York 10476, USA
    Endocrinology 147:3995-4006. 2006
    ..the GLU receptor (Gcgr-/-), which are characterized by lower blood glucose levels and by alpha- and delta-cell hyperplasia in adults...
  98. pmc C-cell hyperplasia, pheochromocytoma and sympathoadrenal malformation in a mouse model of multiple endocrine neoplasia type 2B
    C L Smith-Hicks
    Department of Genetics and Development, College of Physicians and Surgeons, Columbia University, 701 W 168th Street, New York, NY 10032, USA
    EMBO J 19:612-22. 2000
    ..Mutant mice displayed C-cell hyperplasia and chromaffin cell hyperplasia progressing to pheochromocytoma...
  99. ncbi Deficiency of gelatinase a suppresses smooth muscle cell invasion and development of experimental intimal hyperplasia
    Masafumi Kuzuya
    Department of Geriatrics, Nagoya University Graduate School of Medicine, Toyonaka, Nagoya 466 8550, Japan
    Circulation 108:1375-81. 2003
    ..To define the role of MMP-2 in arterial remodeling, we evaluated the influence of the targeted deletion of the MMP-2 gene on vascular remodeling after flow cessation in the murine carotid arteries...
  100. doi Secondary hyperparathyroidism: pathogenesis, disease progression, and therapeutic options
    John Cunningham
    Centre for Nephrology, UCL Medical School, Royal Free Campus, London, United Kingdom
    Clin J Am Soc Nephrol 6:913-21. 2011
    ..These imbalances result in parathyroid hyperplasia and contribute to vascular calcification...
  101. ncbi Towards the treatment of saphenous vein bypass graft failure--a perspective of the Bristol Heart Institute
    Gianni D Angelini
    Bristol Heart Institute, University of Bristol, Bristol, UK
    Biorheology 39:491-9. 2002
    ..The objective of this article, therefore, is to review these recent approaches and their potential clinical applications in the treatment of vein graft disease...

Research Grants77

  1. Air Pollution on Adiposity and Vascular Dysfunction: White or Brown Matters?
    Qinghua Sun; Fiscal Year: 2013
    ..the activity of brown adipose tissue, tissue histological examination to assess mitochondria content, adipocyte hyperplasia and hypertrophy, and vascular growth in the fat tissues, myograph to investigate macrovascular function will be ..
  2. Development of VN/14-1 and Related Analogs for Breast Cancer Therapy
    VINCENT COLLINS OFUKA NJAR; Fiscal Year: 2013
    ..and endocrine resistant (refractory to endocrine therapies) breast cancers, and also antagonize uterine hyperplasia, characteristics that are distinct from those of selective estrogen receptor modulators (SERMs), such as ..
  3. GENETIC ANALYSIS OF POLARITY
    RUTH M STEWARD; Fiscal Year: 2010
    ..Several loss-of-function alleles in zfrp8 cause enormous hyperplasia of the lymph glands, over-proliferation of immature blood cells, and severe growth delay in other tissues...
  4. BIOSYNTHESIS OF TRACHEAL MUCOUS GLYCOPROTEINS
    Pi Wan Cheng; Fiscal Year: 2010
    ..This condition is the result of hypertrophy and hyperplasia of mucus cells...
  5. Mechanism of Bladder Overactivity in Pelvic Ischemia
    Kazem M Azadzoi; Fiscal Year: 2013
    ..In the elderly male, bladder outlet obstruction due to benign prostatic hyperplasia (BPH) has long been blamed...
  6. Physiology of Hypothalamic Neurosteroidal Progesterone
    Paul E Micevych; Fiscal Year: 2013
    ..This type of infertility exhibits excess estrogen production without ovulation that can lead to polycystic ovary syndrome, irregular vaginal bleeding, metabolic abnormalities as well as endometrial polyps, hyperplasia, and even cancer.
  7. Regulation of epithelial cell homeostasis by actin microfilaments
    Seema Khurana; Fiscal Year: 2010
    ..in apoptosis are associated with several gastrointestinal conditions including villus atrophy, epithelial hyperplasia, loss of normal absorptive function and increased risk of tumorigenesis...
  8. Cellular &Molecular Defects in Human B Cell Development
    Charlotte Cunningham-Rundles; Fiscal Year: 2013
    ..with TACI mutation especially in heterozygous form are significantly more likely to develop striking lymphoid hyperplasia and autoimmunity...
  9. Unbiased genome-wide screen to identify genes regulating mucous cell hyperplasia
    Jeffrey A Whitsett; Fiscal Year: 2010
    ..of candidate genes and their association with the pulmonary disease processes complicated by mucous cell hyperplasia and mucous hyperproduction will be assessed in tissue from mouse models (in vivo) and in REC cells (in vitro), ..
  10. FOXP3-microRNA146-NFkB Axis in Tumor Suppression
    Lizhong Wang; Fiscal Year: 2013
    ..Since lineage-specific ablation of FoxP3 in the mouse prostate epithelial cells leads to prostate hyperplasia and prostatic intraepithelial neoplasia, this mechanism should have a substantial impact on our understanding ..
  11. Nitric Oxide in Hemodialysis AV Fistula Maturation
    Richard A Cohen; Fiscal Year: 2010
    ..disease (ESRD), yet nearly 50% of fistulas fail soon after their surgical construction due, in part, to intimal hyperplasia of venous smooth muscle cells (SMC) that occludes the fistula lumen...
  12. Air Pollution on Adiposity and Vascular Dysfunction: White or Brown Matters?
    Qinghua Sun; Fiscal Year: 2010
    ..the activity of brown adipose tissue, tissue histological examination to assess mitochondria content, adipocyte hyperplasia and hypertrophy, and vascular growth in the fat tissues, intravital microscopy to illustrate microvascular ..
  13. Improved Adventitial Sirolimus Therapy for Peripheral Artery Restenosis
    KIRK SEWARD; Fiscal Year: 2010
    ..elastic recoil and flow-limiting dissections but have not significantly impacted restenosis due to intimal hyperplasia [3, 8-10]...
  14. Impaired mitochondrial fusion in pulmonary arterial hypertension
    Stephen L Archer; Fiscal Year: 2010
    ..Relevant to PAH, mitofusin-2 is a brake on SMC proliferation. Indeed, when first cloned, mitofusin-2 was named hyperplasia suppressor gene. Mitofusin-2 gene therapy reduces intimal hyperplasia in a systemic arterial injury model...
  15. Mechanisms of coronary microvascular dysfunction in metabolic syndrome
    Johnathan D Tune; Fiscal Year: 2012
    ..insulin resistance, impaired glucose tolerance, dyslipidemia, hyperleptinemia, hypertension and neointimal hyperplasia. Using this clinically-relevant model, we propose to test the central hypothesis that impaired functional ..
  16. Histamine modulation of biliary proliferation and damage
    Heather L Francis; Fiscal Year: 2013
    ..While down-regulation of HDC and histamine synthesis may be important in the inhibition of biliary hyperplasia, overexpression of HDC (leading to enhanced histamine release) may be key for stimulating biliary proliferation ..
  17. Mechanisms of Obesity in Mice with Neuron-Specific Lipoprotein Lipase Deficiency
    Robert H Eckel; Fiscal Year: 2013
    ..and also demonstrate increases in Mc3r gene expression in the hypothalamus, marked brown adipose tissue (BAT) hyperplasia/hypertrophy and increased BAT UCP-1 gene expression...
  18. Effects of periodontitis on insulin target organs and glucose homeostasis
    Keiko Watanabe; Fiscal Year: 2013
    ..influences pancreatic beta-cells by modulating beta-cell compensatory alterations (insulin secretion, beta-cell hyperplasia &apoptosis) via TLRs...
  19. Link of beta cell proliferation and type 2 diabetes to epigenetic regulation
    Xianxin Hua; Fiscal Year: 2013
    ..endocrine neoplasia type 1 gene (Men1), which encodes the nuclear protein menin, usually result in benign hyperplasia in several endocrine organs, such as pancreatic islets, but do not affect other organs, such as the liver...
  20. Beta-cell Proliferation
    Fredric E Wondisford; Fiscal Year: 2013
    ..These adaptive changes include increased insulin synthesis and secretion as well as hyperplasia and possibly formation of new [unreadable]-cells from progenitor cells...
  21. Role of Stat3 in Breast Cancer Tumorigenesis
    Jacqueline F Bromberg; Fiscal Year: 2010
    ..murine mammary tumor models, preliminary data suggests that inducible expression of Stat3C potentiates hyperplasia, increases tumor multiplicity and enhances metastatic disease...
  22. PHYSIOLOGY AND CLONING OF B FRAGILIS ENTEROTOXIN
    CYNTHIA SEARS; Fiscal Year: 2010
    ..potential of ETBF are further supported by our preliminary data showing ETBF colonization yields colonic hyperplasia and inflammation in conventional mice;rapid, lethal colitis in germ-free mice;and increased colon adenomas in ..
  23. Evaluating Novel Multi-kinase Peptide Inhibitors as a Treatment for Rheumatoid Ar
    DAVID MEN HWEI TSAI; Fiscal Year: 2013
    ..These recent data and the understanding that inflammation, angiogenesis, hyperplasia, and oxidative stress are crucial mediators of RA led us to investigate the potential of AX-3 and its active ..
  24. EFFECT OF LIPIDS ON VASCULAR GRAFT HEALING
    Linda M Graham; Fiscal Year: 2013
    ..surgery, but their long-term patency is limited by their thrombogenicity and the development of intimal hyperplasia. Oxidized LDL and lysophosphatidylcholine (lysoPC), a product of LDL oxidation, accumulate in grafts and alter ..
  25. Markers of Renal Damage in Renovascular Hypertension
    Juan C Romero; Fiscal Year: 2011
    ..under which the CONT-KD may benefit from medical treatment are related to the possible reversal of vascular hyperplasia in preglomerular arterioles and that residual circulation is sufficient to meet the metabolic demands of ..
  26. TNF Family Members and Control of Fibrotic Disease
    Michael Croft; Fiscal Year: 2013
    ..cells, and inflamed epithelial cells, was responsible for mediating collagen production, smooth muscle hyperplasia, and overall fibrotic symptoms...
  27. EPICARDIAL ADIPOSE TISSUE, OBESITY AND INFLAMMATION IN ATHEROSCLEROSIS
    Devendra K Agrawal; Fiscal Year: 2013
    ..epicardial fat is exacerbated by vitamin D deficiency leading to endothelial dysfunction and enhanced intimal hyperplasia following coronary intervention...
  28. The Role of Carboxypeptidase B and its Substrates in Rheumatoid Arthritis
    William H Robinson; Fiscal Year: 2013
    ..Characteristic histologic features in RA joints are synovial hyperplasia, inflammatory cell infiltrates, bone erosions and fibrin deposits...
  29. ROLE OF MUC1 IN THE GENESIS OF ALLERGIC ASTHMA
    Kwang Chul Kim; Fiscal Year: 2010
    ..recent preliminary studies suggest that Muc1-null mice fail to exhibit pulmonary eosinophilia and goblet cell hyperplasia as seen in wild type littermates in an ovalbumin (OVA)-induced asthma model...
  30. Mechanisms for cell specific modulation of proliferation and migration
    Thomas S Monahan; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The proposed research focuses on the formation of intimal hyperplasia, a crucial problem affecting all cardiovascular interventions...
  31. Biologic Activities of IL-36 Cytokines in Psoriasis
    Andrew Johnston; Fiscal Year: 2013
    ..is to understand how the expression, processing and function of IL- 36 cytokines impact on the epidermal hyperplasia seen in psoriasis and identify opportunities for the development of innovative therapeutic strategies...
  32. A Novel Model of, and Pre-clinical Therapy for, Scleroderma Lung Disease
    Sergei P Atamas; Fiscal Year: 2012
    ..the mentioned changes resembling of human SLD, mIL-442 does not induce pulmonary eosinophilia or goblet cell hyperplasia (the features that are common in asthma but not in SLD, and that are readily induced by wild-type mIL-4)...
  33. Control of Cardiogenesis by microRNA Editing
    Kazuko Nishikura; Fiscal Year: 2010
    ..ventricular septal defects or pathological conditions of adult heart such as ventricular hypertrophy, hyperplasia and arrhythmias...
  34. Feto-maternal DNA/RNA Trafficking: Biology and Application
    Diana W Bianchi; Fiscal Year: 2013
    ..clinical utility of fetal gender detection in X-linked conditions, in fetuses at risk for congenital adrenal hyperplasia, and in fetuses with ambiguous genitalia...
  35. AGE-RELATED ALTERATION OF LEYDIG CELL REDOX ENVIRONMENT A RISK FACTOR FOR SUSCEPT
    Kassim Traore; Fiscal Year: 2013
    ..fetal exposures to DEHP have been shown to result in reduced litter size, and, later in life, Leydig cell hyperplasia, testicular atrophy, reduced serum levels of seru testosterone, and reduced fertility...
  36. Mechanisms of arsenic-induced chromosomal instability and carcinogenesis
    Wei Dai; Fiscal Year: 2013
    ..Moreover, mice with haploinsufficiency of BubR1 are prone to the development of skin lesions (hyperplasia) after exposure to UV irradiation...
  37. PDGF-Receptor regulation in Cocaine and Tat mediated Smooth Muscle Hyperplasia
    Navneet Kaur Dhillon; Fiscal Year: 2012
    ..We observed increased pulmonary arteriopathy with smooth muscle hyperplasia in human lung sections from HIV-infected IVDUs compared to HIV non-drug users...
  38. The Forkhead Transcription Factor, FOXO1, and its Role in Pituitary Gland Develop
    BUFFY SUE ELLSWORTH; Fiscal Year: 2010
    ..We hypothesize that eliminating FOXO1 in the pituitary will cause hyperplasia and misorganization of the pituitary gland resulting in loss of hormone production and/or mis-specification of ..
  39. Link of beta cell proliferation and type 2 diabetes to epigenetic regulation.
    Xianxin Hua; Fiscal Year: 2010
    ..endocrine neoplasia type 1 gene (Men1), which encodes the nuclear protein menin, usually result in benign hyperplasia in several endocrine organs, such as pancreatic islets, but do not affect other organs, such as the liver...
  40. PKC/PKA Regulation in Prostate Cancer by SSeCKS/Gravin/AKAP12
    Irwin H Gelman; Fiscal Year: 2013
    ..growth by inhibiting VEGF-induced neovascularization, genetic knockout (KO) in mice induces prostatic hyperplasia and focal dysplasia with evidence of epithelial cell senescence, and KO mouse fibroblasts (MEF) display ..
  41. Nuclear Lipids in Steroidogenesis
    Marion B Sewer; Fiscal Year: 2013
    ..This work will provide insight into multiple endocrine disorders, including adrenal hyperplasia, polycystic ovary syndrome, and Cushing's disease.
  42. Cell Specific Expression in the Pituitary Gland
    Sally A Camper; Fiscal Year: 2013
    ..Little is known about the mechanism of basic thyrotrope specification or the hypertrophy and hyperplasia. The long-term goal of this research is to improve diagnosis and therapy for people with genetic or acquired ..
  43. TGF-Beta in Intimal Hyperplasia after Vascular Bypass
    K Craig Kent; Fiscal Year: 2013
    ..effects on smooth muscle cell (SMC) migration and proliferation would provide a venue for controlling intimal hyperplasia. Our studies have provided new insights into the mechanism of action of TGF-2...
  44. Effect of Chronic Proton Pump Inhibitor Therapy on Bone Mineral Density and Bone
    Yu Xiao Yang; Fiscal Year: 2013
    ..PPI-induced hypergastrinemia has a direct trophic effect on the parathyroid glands, leading to parathyroid hyperplasia, increased parathyroid hormone secretion and bone loss...
  45. Bisphenol A: Urine flow disorder and prostate pathology
    FREDERICK S contact VOM SAAL; Fiscal Year: 2010
    ..These males die due to retention of urine in the bladder associated with extensive periurethral gland hyperplasia;all of these mice also have HGPIN in a majority of prostate acini...
  46. Clinical Study of Disposition and Biological Activity of d-Limonene
    H H Sherry Chow; Fiscal Year: 2010
    ..in women with a recent diagnosis of ductal carcinoma in situ, lobular carcinoma in situ, or atypical ductal hyperplasia elected to undergo excision surgery...
  47. BIOLOGY OF SUBMUCOSAL GLAND STEM CELLS IN THE AIRWAY
    John F Engelhardt; Fiscal Year: 2013
    ..fibrosis (CF), asthma, and chronic bronchitis, Submucosal glands expand in mass (hypertrophy) and/or abundance (hyperplasia), leading to excessive and abnormal mucus production...
  48. Keratin Biology and Disease Aspects in Simple Epithelia
    Bishr Omary; Fiscal Year: 2013
    ..analysis of wild-type and keratin-8 null mouse colonocytes to understand the consequent colitis and colonic hyperplasia that are due to keratin absence...
  49. Enteric Neuronal Development as a Determinant of Intestinal Inflammation
    Kara Gross Margolis; Fiscal Year: 2013
    ..It is impossible to determine in humans whether neuronal hyperplasia predates intestinal inflammation, results from it, or contributes to its severity...
  50. Vascular Structure and Function in Arteriovenous Fistula Maturation
    Jonathan Himmelfarb; Fiscal Year: 2012
    ..and structural changes in the vascular system which includes aggressive development of venous intimal hyperplasia. However, the extent to which these uremia-related functional and structural changes in the vasculature ..
  51. Chemoprevention of Prostate Cancer
    SUSAN AUDREY HALL; Fiscal Year: 2012
    ..questions remain regarding finasteride, a 5-alpha reductase inhibitor currently used for benign prostatic hyperplasia that may also protect against prCA...
  52. Inhibition of Neointimal Hyperplasia Following Vascular Surgery in Diabetes
    MELINA RAE KIBBE; Fiscal Year: 2013
    ..of severe atherosclerosis have high failure rates due to the development of restenosis secondary to neointimal hyperplasia. Nitric oxide (NO) is a small vasoprotective molecule that is known to inhibit the development of neointimal ..
  53. Mechanisms of Interleukin-17 Inflammation Induced by Bacteroides fragilis
    CYNTHIA SEARS; Fiscal Year: 2012
    ..induce a continuum of human pathology from `asymptomatic'colonization, potentially associated with colonic hyperplasia and inflammation (precursor conditions to neoplastic transformation), to inflammatory diarrhea and colitis...
  54. Defining the role of Amot lipid binding in cellular proliferation and migration
    ANN CAROL KIMBLE-HILL; Fiscal Year: 2013
    ..enables specific modulation of cellular polarity events which ultimately impacts the progression of ductal cell hyperplasia into breast cancer...
  55. TR4 orphan receptor, a longevity assurance gene, in prostate carcinogenesis
    Yi Fen Lee; Fiscal Year: 2012
    ..A few surviving "aged" TR4-/- mice developed abnormal proliferative lesions of prostatic hyperplasia and/or dysplasia at the age of 17 months while wild type littermates retained an intact prostatic structure...
  56. Brown Adipose Tissue Vasculature Probes for Non-Invasive Imaging
    Mikhail G Kolonin; Fiscal Year: 2011
    ..in energy dissipation through adaptive thermogenesis opposes the action of white adipocytes, hypertrophy and hyperplasia of which are responsible for obesity...
  57. Lymphatic Regulation of Skin Electrolyte Metabolism and Blood Pressure
    JENS MARC TITZE; Fiscal Year: 2013
    ..Macrophages induce hyperplasia of subcutaneous lymph capillaries after sensing local Na+ or Cl- overload in the interstitium...
  58. Neurogenic inflammation and psoriasiform dermatitis
    NICOLE LEANNE WARD; Fiscal Year: 2013
    ..role and contribution of nerves to the cellular and molecular mechanisms mediating cutaneous inflammation and hyperplasia remains poorly defined...
  59. CELLULAR MECHANISMS OF PTLD IN TRANSPLANT RECIPIENTS
    Olivia M Martinez; Fiscal Year: 2012
    ..heterogeneous complication of solid organ and bone marrow transplantation that ranges from benign B cell hyperplasia to malignant lymphoma...
  60. MECHANISMS OF ARTERIAL GRAFT HEALING
    Alexander W Clowes; Fiscal Year: 2013
    ..during the first year in approximately 25-30% of all grafts because of pathological remodeling and intimal hyperplasia, is a primary cause of graft thrombosis...
  61. MSM Mapping and Modeling ErbB Receptor Membrane Topogra
    Bridget S Wilson; Fiscal Year: 2012
    ..cancers, such breast, ovarian and prostate, develop in a multistep process that starts from a local benign hyperplasia and ends with an invasive tumor able to metastasize to other organs...
  62. Validation of Biomarkers to Distinguish Aggressive from Indolent Prostate Cancer
    George Wilding; Fiscal Year: 2013
    ..in several resected prostate tissue microarrays (TMA) consisting of normal prostate, benign prostatic hyperplasia (BPH), prostatic intraepithelial neoplasia (PIN), localized low grade PCa, high grade PCa and metastatic PCa ..
  63. Impact of Inflammatory Genes on Glandular Hyperplasia in Children with Sinusitis
    Mary C Rose; Fiscal Year: 2010
    ..Upregulation of glandular genes is consistent with the submucosal gland hyperplasia manifested in the sinus tissues of CRS patients...
  64. PAI-1 and Vitronectin in Failure of Coronary Revascularization
    William P Fay; Fiscal Year: 2013
    ..PAI-1 and VN play major roles in regulating vascular smooth muscle cell (VSMC) migration and intimal hyperplasia, which cause restenosis after percutaneous coronary intervention (PCI) and are central processes in the ..
  65. Development of a novel vaccine for protection against gammaherpesvirus infection
    Blossom A Damania; Fiscal Year: 2010
    ..RRV has been shown to induce B cell hyperplasia and lymphoma in the context of SIV co-infection...
  66. HISTOMETRIC ANALYSIS OF PREMALIGNANT ENDOMETRIAL LESIONS
    Francisco Garcia; Fiscal Year: 2003
    ..The current management of atypical endometrial hyperplasia is limited to hysterectomy...
  67. AKT 1 AND MAMMARY CELL SURVIVAL DURING THE ESTRUS CYCLE
    Robert Strange; Fiscal Year: 2004
    ..and apoptosis are not well balanced during the menstrual cycle, these cyclic changes may result in mammary hyperplasia and an increased risk for breast cancer...
  68. Diet and the Calcium Channel TRPV6 in Colon Hyperplasia
    Sara Peleg; Fiscal Year: 2010
    ..increase susceptibility to malignant transformation, we have employed the model of transmissible murine colonic hyperplasia (TMCH) induced by the gram-negative bacterium citrobacter rodentium (CR)...
  69. Aromatase Inhibitor in Males with Adrenal Hyperplasia
    Kyriakie Sarafoglou; Fiscal Year: 2006
    unreadable] DESCRIPTION (provided by applicant): Our objective is to treat males who have congenital adrenal hyperplasia (CAH) and decreased spermatogenesis with an aromatase inhibitor in order to investigate its effects on hormonal ..
  70. MEDICAL THERAPY IN BENIGN PROSTATIC HYPERPLASIA
    Michael Lieber; Fiscal Year: 2001
    Two different types of medical therapy for the symptoms of benign prostatic hyperplasia (BPH) now have been approved by the U.S. Food and Drug Administration...
  71. Controlled Release Vascular Grafts
    ANTONIO WEBB; Fiscal Year: 2009
    ..most commonly used alternative despite dismal patency rates due to the formation of thrombosis and neointimal hyperplasia. To address these problems, many researchers have been investigating alternative strategies that involve ..
  72. GOBLET CELL DYSFUNCTION IN ASTHMA
    John Fahy; Fiscal Year: 2002
    ..Although goblet cell hyperplasia is a pathologic feature of animal models of asthma, and allergen-induced goblet cell degranulation causes ..
  73. Formulated Phytosterols - A New Treatment For Benign Prostatic Hyperplasia
    CURTIS SPILBURG; Fiscal Year: 2006
    unreadable] DESCRIPTION (provided by applicant): Benign prostatic hyperplasia (BPH) refers to the enlargement of the prostate gland, which occurs in 50% of 60-year old men with increasing incidence with age...
  74. Prolactin and Estrogens as Mitogens in Prostate Cancer
    Nira Ben Jonathan; Fiscal Year: 2002
    ..Overproduction of PRL by prostate cells results in prostatic hyperplasia in mice...
  75. RECEPTOR KINASE GENE THERAPY FOR NEOINTIMAL HYPERPLASIA
    Neil Freedman; Fiscal Year: 2002
    ..complicated by proliferation of smooth muscle cells in the vessel subintima, in a process termed neointimal hyperplasia. Neointimal hyperplasia leads to significant coronary restenosis in approximately 30% of PTCA cases, and ..
  76. Vitamin D Control of TGFa/EFG Receptor Growth Signaling
    Adriana Dusso; Fiscal Year: 2006
    ..b>Hyperplasia of PTH-producing cells is a major cause of high serum PTH levels...
  77. DIAGNOSTIC CENTER
    M Lucia; Fiscal Year: 2004
    ..The investigators describe the widespread economic and medical problems associated with benign prostatic hyperplasia. The overall goal of the study is to test the effectiveness of pharmacological intervention in benign prostatic ..