hemorrhage

Summary

Summary: Bleeding or escape of blood from a vessel.

Top Publications

  1. doi Rivaroxaban versus warfarin in nonvalvular atrial fibrillation
    Manesh R Patel
    Duke Clinical Research Institute, Duke University Medical Center, Durham, NC 27705, USA
    N Engl J Med 365:883-91. 2011
  2. doi Dabigatran versus warfarin in patients with atrial fibrillation
    Stuart J Connolly
    Population Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, ON, Canada
    N Engl J Med 361:1139-51. 2009
  3. doi Apixaban versus warfarin in patients with atrial fibrillation
    Christopher B Granger
    Duke Clinical Research Institute, Duke University Medical Center, Durham, NC 27715, USA
    N Engl J Med 365:981-92. 2011
  4. doi A novel user-friendly score (HAS-BLED) to assess 1-year risk of major bleeding in patients with atrial fibrillation: the Euro Heart Survey
    Ron Pisters
    Department of Cardiology, Maastricht University Medical Centre, Maastricht, The Netherlands
    Chest 138:1093-100. 2010
  5. ncbi Definition of major bleeding in clinical investigations of antihemostatic medicinal products in non-surgical patients
    S Schulman
    Coagulation Unit, Karolinska University Hospital, Stockholm, Sweden
    J Thromb Haemost 3:692-4. 2005
  6. doi The importance of early treatment with tranexamic acid in bleeding trauma patients: an exploratory analysis of the CRASH-2 randomised controlled trial
    Ian Roberts
    Clinical Trials Unit, London School of Hygiene and Tropical Medicine, London WC1E 7HT, UK
    Lancet 377:1096-101, 1101.e1-2. 2011
  7. doi Radial versus femoral access for coronary angiography and intervention in patients with acute coronary syndromes (RIVAL): a randomised, parallel group, multicentre trial
    Sanjit S Jolly
    McMaster University and the Population Health Research Institute, Hamilton Health Sciences, Hamilton, ON, Canada
    Lancet 377:1409-20. 2011
  8. doi Apixaban for extended treatment of venous thromboembolism
    Giancarlo Agnelli
    Department of Internal and Cardiovascular Medicine Stroke Unit, University of Perugia, Perugia, Italy
    N Engl J Med 368:699-708. 2013
  9. doi Extended use of dabigatran, warfarin, or placebo in venous thromboembolism
    Sam Schulman
    Department of Medicine, McMaster University and Thrombosis and Atherosclerosis Research Institute, Hamilton, ON, Canada
    N Engl J Med 368:709-18. 2013
  10. doi Rivaroxaban versus enoxaparin for thromboprophylaxis after total knee arthroplasty (RECORD4): a randomised trial
    Alexander G G Turpie
    McMaster University, Hamilton, Ontario L8L 2X2, Canada
    Lancet 373:1673-80. 2009

Detail Information

Publications398 found, 100 shown here

  1. doi Rivaroxaban versus warfarin in nonvalvular atrial fibrillation
    Manesh R Patel
    Duke Clinical Research Institute, Duke University Medical Center, Durham, NC 27705, USA
    N Engl J Med 365:883-91. 2011
    ..Rivaroxaban, an oral factor Xa inhibitor, may provide more consistent and predictable anticoagulation than warfarin...
  2. doi Dabigatran versus warfarin in patients with atrial fibrillation
    Stuart J Connolly
    Population Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, ON, Canada
    N Engl J Med 361:1139-51. 2009
    Warfarin reduces the risk of stroke in patients with atrial fibrillation but increases the risk of hemorrhage and is difficult to use. Dabigatran is a new oral direct thrombin inhibitor.
  3. doi Apixaban versus warfarin in patients with atrial fibrillation
    Christopher B Granger
    Duke Clinical Research Institute, Duke University Medical Center, Durham, NC 27715, USA
    N Engl J Med 365:981-92. 2011
    ..Apixaban is a novel oral direct factor Xa inhibitor that has been shown to reduce the risk of stroke in a similar population in comparison with aspirin...
  4. doi A novel user-friendly score (HAS-BLED) to assess 1-year risk of major bleeding in patients with atrial fibrillation: the Euro Heart Survey
    Ron Pisters
    Department of Cardiology, Maastricht University Medical Centre, Maastricht, The Netherlands
    Chest 138:1093-100. 2010
    ..We aimed to develop a practical risk score to estimate the 1-year risk for major bleeding (intracranial, hospitalization, hemoglobin decrease > 2 g/L, and/or transfusion) in a cohort of real-world patients with AF...
  5. ncbi Definition of major bleeding in clinical investigations of antihemostatic medicinal products in non-surgical patients
    S Schulman
    Coagulation Unit, Karolinska University Hospital, Stockholm, Sweden
    J Thromb Haemost 3:692-4. 2005
    ..The intention is to also seek approval of this definition from the regulatory authorities...
  6. doi The importance of early treatment with tranexamic acid in bleeding trauma patients: an exploratory analysis of the CRASH-2 randomised controlled trial
    Ian Roberts
    Clinical Trials Unit, London School of Hygiene and Tropical Medicine, London WC1E 7HT, UK
    Lancet 377:1096-101, 1101.e1-2. 2011
    ..Tranexamic acid significantly reduced all-cause mortality. Because tranexamic acid is thought to exert its effect through inhibition of fibrinolysis, we undertook exploratory analyses of its effect on death due to bleeding...
  7. doi Radial versus femoral access for coronary angiography and intervention in patients with acute coronary syndromes (RIVAL): a randomised, parallel group, multicentre trial
    Sanjit S Jolly
    McMaster University and the Population Health Research Institute, Hamilton Health Sciences, Hamilton, ON, Canada
    Lancet 377:1409-20. 2011
    ..We aimed to assess whether radial access was superior to femoral access in patients with acute coronary syndromes (ACS) who were undergoing coronary angiography with possible intervention...
  8. doi Apixaban for extended treatment of venous thromboembolism
    Giancarlo Agnelli
    Department of Internal and Cardiovascular Medicine Stroke Unit, University of Perugia, Perugia, Italy
    N Engl J Med 368:699-708. 2013
    ..Apixaban, an oral factor Xa inhibitor that can be administered in a simple, fixed-dose regimen, may be an option for the extended treatment of venous thromboembolism...
  9. doi Extended use of dabigatran, warfarin, or placebo in venous thromboembolism
    Sam Schulman
    Department of Medicine, McMaster University and Thrombosis and Atherosclerosis Research Institute, Hamilton, ON, Canada
    N Engl J Med 368:709-18. 2013
    ..Dabigatran, which is administered in a fixed dose and does not require laboratory monitoring, may be suitable for extended treatment of venous thromboembolism...
  10. doi Rivaroxaban versus enoxaparin for thromboprophylaxis after total knee arthroplasty (RECORD4): a randomised trial
    Alexander G G Turpie
    McMaster University, Hamilton, Ontario L8L 2X2, Canada
    Lancet 373:1673-80. 2009
    ..We aimed to test the efficacy and safety of oral rivaroxaban for the prevention of venous thromboembolism after total knee arthroplasty...
  11. ncbi Intraplaque hemorrhage and progression of coronary atheroma
    Frank D Kolodgie
    Department of Cardiovascular Pathology, Armed Forces Institute of Pathology, Washington, DC 20306 6000, USA
    N Engl J Med 349:2316-25. 2003
    Intraplaque hemorrhage is common in advanced coronary atherosclerotic lesions. The relation between hemorrhage and the vulnerability of plaque to disruption may involve the accumulation of free cholesterol from erythrocyte membranes.
  12. doi Dabigatran versus warfarin in patients with atrial fibrillation: an analysis of patients undergoing cardioversion
    Rangadham Nagarakanti
    Louisiana State University School of Medicine, New Orleans, LA, USA
    Circulation 123:131-6. 2011
    ..The Randomized Evaluation of Long-Term Anticoagulation Therapy (RE-LY) trial compared dabigatran 110 mg BID (D110) and 150 mg BID (D150) with warfarin for stroke prevention in 18 113 patients with nonvalvular atrial fibrillation...
  13. ncbi The ratio of blood products transfused affects mortality in patients receiving massive transfusions at a combat support hospital
    Matthew A Borgman
    Brooke Army Medical Center, Fort Sam Houston, TX, USA
    J Trauma 63:805-13. 2007
    ..The risk of death from hemorrhagic shock increases in this population. To treat the coagulopathy of trauma, some have suggested early, aggressive correction using a 1:1 ratio of plasma to red blood cell (RBC) units...
  14. ncbi Dabigatran etexilate versus enoxaparin for prevention of venous thromboembolism after total hip replacement: a randomised, double-blind, non-inferiority trial
    Bengt I Eriksson
    Department of Orthopaedic Surgery, Sahlgrenska University Hospital Ostra, Gothenburg, Sweden
    Lancet 370:949-56. 2007
    ..After hip replacement surgery, prophylaxis following discharge from hospital is recommended to reduce the risk of venous thromboembolism. Our aim was to assess the oral, direct thrombin inhibitor dabigatran etexilate for such prophylaxis...
  15. doi Cost-effectiveness of dabigatran for stroke prophylaxis in atrial fibrillation
    Shimoli V Shah
    Department of Medicine, Washington University School of Medicine, Campus Box 8005, 660 S Euclid Ave, St Louis, MO 63110, USA
    Circulation 123:2562-70. 2011
    ..Recent studies have investigated alternatives to warfarin for stroke prophylaxis in patients with atrial fibrillation (AF), but whether these alternatives are cost-effective is unknown...
  16. doi Ticagrelor versus clopidogrel in patients with acute coronary syndromes
    Lars Wallentin
    Uppsala Clinical Research Center, Uppsala, Sweden
    N Engl J Med 361:1045-57. 2009
    ..Ticagrelor is an oral, reversible, direct-acting inhibitor of the adenosine diphosphate receptor P2Y12 that has a more rapid onset and more pronounced platelet inhibition than clopidogrel...
  17. pmc Assessment of intramyocardial hemorrhage by T1-weighted cardiovascular magnetic resonance in reperfused acute myocardial infarction
    Steen Fjord Pedersen
    Department of Cardiothoracic and Vascular Surgery T, Aarhus University Hospital Skejby, Brendstrupsgaardsvej 100, Aarhus N DK 8200, Denmark
    J Cardiovasc Magn Reson 14:59. 2012
    ..The results were compared to T2-weighthed short tau inversion recovery (T2-STIR), and T2*-weighted(T2*W) sequences...
  18. doi Risk of bleeding with 2 doses of dabigatran compared with warfarin in older and younger patients with atrial fibrillation: an analysis of the randomized evaluation of long-term anticoagulant therapy (RE-LY) trial
    John W Eikelboom
    Population Health Research Institute, Hamilton Health Sciences and McMaster University, Hamilton, Ontario, Canada
    Circulation 123:2363-72. 2011
    ..The purpose of this study was to compare their risks of bleeding in the Randomized Evaluation of Long-Term Anticoagulant Therapy (RE-LY) trial...
  19. ncbi Meta-analysis: antithrombotic therapy to prevent stroke in patients who have nonvalvular atrial fibrillation
    Robert G Hart
    Department of Medicine Neurology, University of Texas Health Science Center, San Antonio, Texas 78229 3900, USA
    Ann Intern Med 146:857-67. 2007
    ..Atrial fibrillation is a strong independent risk factor for stroke...
  20. doi Indirect comparisons of new oral anticoagulant drugs for efficacy and safety when used for stroke prevention in atrial fibrillation
    Gregory Y H Lip
    University of Birmingham Centre for Cardiovascular Sciences, City Hospital, Birmingham, UK
    J Am Coll Cardiol 60:738-46. 2012
    ..This study sought to perform an indirect comparison analysis of dabigatran etexilate (2 doses), rivaroxaban, and apixaban for their relative efficacy and safety against each other...
  21. ncbi In vivo accuracy of multispectral magnetic resonance imaging for identifying lipid-rich necrotic cores and intraplaque hemorrhage in advanced human carotid plaques
    C Yuan
    Department of Radiology, University of Washington, Seattle, WA 98195, USA
    Circulation 104:2051-6. 2001
    ..MRI has been shown to be capable of identifying plaque constituents, such as the necrotic core and intraplaque hemorrhage, in human carotid atherosclerosis...
  22. pmc Enhancement by tumor necrosis factor alpha of dengue virus-induced endothelial cell production of reactive nitrogen and oxygen species is key to hemorrhage development
    Yu Ting Yen
    Graduate Institute of Immunology, National Taiwan University College of Medicine, No 1 Jen Ai Road, Section 1, Taipei, Taiwan
    J Virol 82:12312-24. 2008
    b>Hemorrhage is a severe manifestation of dengue disease. Virus strain and host immune response have been implicated as the risk factors for hemorrhage development...
  23. doi Concomitant use of antiplatelet therapy with dabigatran or warfarin in the Randomized Evaluation of Long-Term Anticoagulation Therapy (RE-LY) trial
    Antonio L Dans
    College of Medicine, University of the Philippines Manila, Ermita, Manila, Philippines 1000
    Circulation 127:634-40. 2013
    ..In this subgroup analysis, we assess the efficacy and safety of dabigatran in patients who did and did not receive concomitant antiplatelets...
  24. doi An indirect comparison of dabigatran, rivaroxaban and apixaban for atrial fibrillation
    Simon Mantha
    Department of Hematology, Lahey Clinic, Burlington, MA 01805, USA
    Thromb Haemost 108:476-84. 2012
    ..Such an indirect comparison should be used only to generate hypotheses which need to be tested in a dedicated randomised trial comparing the three drugs directly...
  25. doi Increased plasma and platelet to red blood cell ratios improves outcome in 466 massively transfused civilian trauma patients
    John B Holcomb
    United States Army Institute of Surgical Research, Ft Sam Houston, TX 78234, USA
    Ann Surg 248:447-58. 2008
    ....
  26. doi Dabigatran vs. placebo in patients with acute coronary syndromes on dual antiplatelet therapy: a randomized, double-blind, phase II trial
    Jonas Oldgren
    Uppsala Clinical Research Center and Department of Medical Sciences, Uppsala University, S 751 85 Uppsala, Sweden
    Eur Heart J 32:2781-9. 2011
    ..We evaluated the safety and indicators of efficacy of the novel oral direct thrombin inhibitor dabigatran...
  27. doi Evaluation of risk stratification schemes for ischaemic stroke and bleeding in 182 678 patients with atrial fibrillation: the Swedish Atrial Fibrillation cohort study
    Leif Friberg
    Department of Cardiology, Karolinska Instituet, Danderyd University Hospital, Stockholm, Sweden
    Eur Heart J 33:1500-10. 2012
    ..Our objective was to investigate risk factors for stroke and bleeding in AF, and application of the new CHA(2)DS(2)-VASc and HAS-BLED schemes for stroke and bleeding risk assessments, respectively...
  28. doi Radial versus femoral access for coronary angiography or intervention and the impact on major bleeding and ischemic events: a systematic review and meta-analysis of randomized trials
    Sanjit S Jolly
    Department of Medicine, Population Health Research Institute, Hamilton Health Sciences, McMaster University, Hamilton, ON, Canada
    Am Heart J 157:132-40. 2009
    ..The objective of this meta-analysis was to determine if radial access reduces major bleeding and as a result can reduce death and ischemic events compared to femoral access...
  29. ncbi Efficacy and safety of recombinant human activated protein C for severe sepsis
    G R Bernard
    Division of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    N Engl J Med 344:699-709. 2001
    ..In this phase 3 trial, we assessed whether treatment with drotrecogin alfa activated reduced the rate of death from any cause among patients with severe sepsis...
  30. doi Cost-effectiveness of dabigatran compared with warfarin for stroke prevention in atrial fibrillation
    James V Freeman
    Stanford University School of Medicine, California, USA
    Ann Intern Med 154:1-11. 2011
    ..Warfarin reduces the risk for ischemic stroke in patients with atrial fibrillation (AF) but increases the risk for hemorrhage. Dabigatran is a fixed-dose, oral direct thrombin inhibitor with similar or reduced rates of ischemic stroke and ..
  31. ncbi Clinical classification schemes for predicting hemorrhage: results from the National Registry of Atrial Fibrillation (NRAF)
    Brian F Gage
    Division of General Medical Sciences, Washington University School of Medicine, St Louis, MO 63110, USA
    Am Heart J 151:713-9. 2006
    Although warfarin and other anticoagulants can prevent ischemic events, they can cause hemorrhage. Quantifying the rate of hemorrhage is crucial for determining the risks and net benefits of prescribing antithrombotic therapy...
  32. pmc Coronary intraplaque hemorrhage evokes a novel atheroprotective macrophage phenotype
    Joseph J Boyle
    Vascular Sciences Section, National Heart and Lung Institute, Faculty of Medicine, Imperial College London, Hammersmith Hospital, Du Cane Road, London W12 0NN, U K
    Am J Pathol 174:1097-108. 2009
    Intraplaque hemorrhage accelerates atherosclerosis via oxidant stress and contributes to lesion development and destabilization...
  33. doi Efficacy and safety of dabigatran compared with warfarin at different levels of international normalised ratio control for stroke prevention in atrial fibrillation: an analysis of the RE-LY trial
    Lars Wallentin
    Uppsala Clinical Research Centre, Uppsala University, Uppsala, Sweden
    Lancet 376:975-83. 2010
    ..We aimed to investigate the primary and secondary outcomes of the RE-LY trial in relation to each centre's mean TTR (cTTR) in the warfarin population...
  34. pmc Inflammation induces hemorrhage in thrombocytopenia
    Tobias Goerge
    Immune Disease Institute, Harvard Medical School, Boston, MA, USA
    Blood 111:4958-64. 2008
    ..The mice showed massive hemorrhage that was limited to the area of inflammation and was not observed in uninflamed thrombocytopenic mice...
  35. doi QuikClot use in trauma for hemorrhage control: case series of 103 documented uses
    Peter Rhee
    Department of Surgery, University of Arizona, Tucson, Arizona, USA
    J Trauma 64:1093-9. 2008
    Local hemostatics have recently been introduced for field use to control external hemorrhage. The objective of this report is to describe the initial clinical experience with QuikClot, a zeolite that works by absorbing water and ..
  36. pmc Novel insights for systemic inflammation in sepsis and hemorrhage
    Bolin Cai
    Laboratory of Anti inflammatory Signaling and Surgical Immunology, Department of Surgery, UMDNJ New Jersey Medical School, 185 South Orange Avenue, Newark, NJ 07103, USA
    Mediators Inflamm 2010:642462. 2010
    The inflammatory responses in sepsis and hemorrhage remain a major cause of death. Clinically, it is generally accepted that shock in sepsis or hemorrhage differs in its mechanisms...
  37. doi Regional citrate versus heparin anticoagulation for continuous renal replacement therapy: a meta-analysis of randomized controlled trials
    Mei Yi Wu
    Division of Nephrology, Department of Internal Medicine, Taipei Medical University Shuang Ho Hospital, Taipei, Taiwan
    Am J Kidney Dis 59:810-8. 2012
    ..Heparin is the classic choice for anticoagulation, although it may increase the risk of bleeding. Regional citrate anticoagulation reduces the risk of bleeding, but may cause hypocalcemia and metabolic disturbances...
  38. doi Intravenous platelet blockade with cangrelor during PCI
    Deepak L Bhatt
    VA Boston Healthcare System and Brigham and Women s Hospital, Boston, MA 02132, USA
    N Engl J Med 361:2330-41. 2009
    ..Intravenous cangrelor, a rapid-acting, reversible adenosine diphosphate (ADP) receptor antagonist, might reduce ischemic events during percutaneous coronary intervention (PCI)...
  39. doi Platelet inhibition with cangrelor in patients undergoing PCI
    Robert A Harrington
    Duke Clinical Research Institute, Duke University Medical Center, Durham, NC 27705, USA
    N Engl J Med 361:2318-29. 2009
    ..This agent might have a role in the treatment of patients who require rapid, predictable, and profound but reversible platelet inhibition...
  40. ncbi Comparison of outcomes among patients randomized to warfarin therapy according to anticoagulant control: results from SPORTIF III and V
    Harvey D White
    Green Lane Cardiovascular Service, Auckland City Hospital, Auckland 1030, New Zealand
    Arch Intern Med 167:239-45. 2007
    ..Target INRs are frequently not achieved, and the risk of death, bleeding, myocardial infarction (MI), and stroke or systemic embolism event (SEE) may be related to INR control...
  41. doi Apixaban with antiplatelet therapy after acute coronary syndrome
    John H Alexander
    Duke Clinical Research Institute, Duke University Medical Center, Durham, NC 27715, USA
    N Engl J Med 365:699-708. 2011
    ..Apixaban, an oral, direct factor Xa inhibitor, may reduce the risk of recurrent ischemic events when added to antiplatelet therapy after an acute coronary syndrome...
  42. doi Citrate anticoagulation for continuous venovenous hemofiltration
    Heleen M Oudemans-van Straaten
    Department of Intensive Care Medicine, Onze Lieve Vrouwe Gasthuis, Amsterdam, The Netherlands
    Crit Care Med 37:545-52. 2009
    ..Heparins used to prevent circuit clotting may cause bleeding. Regional anticoagulation with citrate reduces bleeding, but has metabolic risks. The aim was to compare the safety and efficacy of the two...
  43. ncbi Recurrent venous thromboembolism and bleeding complications during anticoagulant treatment in patients with cancer and venous thrombosis
    Paolo Prandoni
    Department of Medical and Surgical Sciences, Second Chair of Internal Medicine, University Hospital of Padua, Italy
    Blood 100:3484-8. 2002
    ..These risks correlate with the extent of cancer. Possibilities for improvement using the current paradigms of anticoagulation seem limited and new treatment strategies should be developed...
  44. ncbi Epidemic leptospirosis associated with pulmonary hemorrhage-Nicaragua, 1995
    R T Trevejo
    Centers for Disease Control, Epidemiology Program Office, Managua, Nicaragua
    J Infect Dis 178:1457-63. 1998
    ..1%) and 15 (0.7%) died with pulmonary hemorrhage. A case-control study found that case-patients were more likely than controls to have ever walked in creeks (..
  45. doi Randomised, parallel-group, multicentre, multinational phase 2 study comparing edoxaban, an oral factor Xa inhibitor, with warfarin for stroke prevention in patients with atrial fibrillation
    Jeffrey I Weitz
    Thrombosis and Atherosclerosis Research Institute, Hamilton General Hospital, Ontario, Canada
    Thromb Haemost 104:633-41. 2010
    ..In contrast, the edoxaban bid regimens were associated with more bleeding than warfarin. These results suggest that in this three-month study, edoxaban 30 or 60 mg qd are safe and well-tolerated...
  46. doi Diffuse alveolar hemorrhage
    Abigail R Lara
    University of Colorado Health Sciences Center, Division of Pulmonary Sciences and Critical Care, 4200 E 9th Ave, Box C272, Denver, CO 80262, USA
    Chest 137:1164-71. 2010
    Diffuse alveolar hemorrhage (DAH) is often a catastrophic clinical syndrome causing respiratory failure...
  47. ncbi Factors affecting bleeding risk during anticoagulant therapy in patients with atrial fibrillation: observations from the Atrial Fibrillation Follow-up Investigation of Rhythm Management (AFFIRM) study
    John P Dimarco
    Cardiovascular Division, University of Virginia Health System, Charlottesville, VA 22908, USA
    Am Heart J 149:650-6. 2005
    ..Bleeding is the major complication of anticoagulant treatment, and the relative risks for bleeding vs stroke must be considered when starting anticoagulation...
  48. ncbi Carotid intraplaque hemorrhage predicts recurrent symptoms in patients with high-grade carotid stenosis
    Nishath Altaf
    Department of Academic Radiology, University of Nottingham, Queen s Medical Centre, Nottingham, UK
    Stroke 38:1633-5. 2007
    Carotid intraplaque hemorrhage (IPH), known to be associated with plaque instability, may convey a higher stroke risk...
  49. ncbi Impact of hemorrhage on trauma outcome: an overview of epidemiology, clinical presentations, and therapeutic considerations
    David S Kauvar
    United States Army Institute of Surgical Research, Fort Sam Houston, San Antonio, Texas 78234, USA
    J Trauma 60:S3-11. 2006
    The world-wide impact of traumatic injury and associated hemorrhage on human health and well-being cannot be overstated. Twelve percent of the global disease burden is the result of violence or accidental injury...
  50. doi International clinical practice guidelines for the treatment and prophylaxis of venous thromboembolism in patients with cancer
    D Farge
    Assistance Publique Hopitaux de Paris, Internal Medicine and Vascular Disease Unit, Saint Louis Hospital, Paris, France
    J Thromb Haemost 11:56-70. 2013
    ..Guidelines addressing the management of venous thromboembolism (VTE) in cancer patients are heterogeneous and their implementation has been suboptimal worldwide...
  51. doi Rivaroxaban versus placebo in patients with acute coronary syndromes (ATLAS ACS-TIMI 46): a randomised, double-blind, phase II trial
    J L Mega
    TIMI Study Group, Boston, MA, USA
    Lancet 374:29-38. 2009
    ..However, its use after acute coronary syndromes has not been investigated. In this setting, we assessed the safety and efficacy of rivaroxaban and aimed to select the most favourable dose and dosing regimen...
  52. doi Risk of bleeding with single, dual, or triple therapy with warfarin, aspirin, and clopidogrel in patients with atrial fibrillation
    Morten L Hansen
    Department of Cardiology, Copenhagen University Hospital Gentofte, Niels Andersens Vej 65 2900, Hellerup, Copenhagen, Denmark
    Arch Intern Med 170:1433-41. 2010
    ..Patients with atrial fibrillation (AF) often require anticoagulation and platelet inhibition, but data are limited on the bleeding risk of combination therapy...
  53. ncbi Paucity of studies to support that abnormal coagulation test results predict bleeding in the setting of invasive procedures: an evidence-based review
    Jodi B Segal
    Department of Medicine, Johns Hopkins University School of Medicine, 1830 E Monument Street, Baltimore, MD 21205, USA
    Transfusion 45:1413-25. 2005
    ..The literature was systematically reviewed to determine whether a prolonged prothrombin time or elevated international normalized ratio predicts bleeding during invasive diagnostic procedures...
  54. doi Results of the CONTROL trial: efficacy and safety of recombinant activated Factor VII in the management of refractory traumatic hemorrhage
    Carl J Hauser
    Department of Surgery, Harvard Medical School and Beth Israel Deaconess Medical Center, Boston, Massachusetts 02216, USA
    J Trauma 69:489-500. 2010
    ..Traumatic coagulopathy contributes to early death by exsanguination and late death in multiple organ failure. Recombinant Factor VIIa (rFVIIa, NovoSeven) is a procoagulant that might limit bleeding and improve trauma outcomes...
  55. doi Apixaban versus enoxaparin for thromboprophylaxis after hip replacement
    Michael Rud Lassen
    Department of Orthopedics, Spine Clinic, and Clinical Trial Unit, Hørsholm Hospital, University of Copenhagen, Hørsholm, Denmark
    N Engl J Med 363:2487-98. 2010
    ..Orally active, specific factor Xa inhibitors such as apixaban may provide effective thromboprophylaxis with a lower risk of bleeding and improved ease of use...
  56. pmc Use of pharmacogenetic and clinical factors to predict the therapeutic dose of warfarin
    B F Gage
    Department of Internal Medicine, Washington University School of Medicine, St Louis, Missouri, USA
    Clin Pharmacol Ther 84:326-31. 2008
    ..used the pharmacogenetic-dosing algorithm in patients initiating warfarin therapy, two of whom had a major hemorrhage. To facilitate use of these pharmacogenetic and clinical algorithms, we developed a nonprofit website, http://..
  57. pmc Aspirin in the primary and secondary prevention of vascular disease: collaborative meta-analysis of individual participant data from randomised trials
    Colin Baigent
    CTSU, Oxford University, Oxford, UK
    Lancet 373:1849-60. 2009
    ..Low-dose aspirin is of definite and substantial net benefit for many people who already have occlusive vascular disease. We have assessed the benefits and risks in primary prevention...
  58. doi Six-month versus 12-month dual antiplatelet therapy after implantation of drug-eluting stents: the Efficacy of Xience/Promus Versus Cypher to Reduce Late Loss After Stenting (EXCELLENT) randomized, multicenter study
    Hyeon Cheol Gwon
    Department of Internal Medicine, Cardiovascular Center, Seoul National University Hospital, 101 Daehak Ro, Jongro Gu, Seoul, 110 744, Korea
    Circulation 125:505-13. 2012
    ..We aimed to test whether 6-month DAPT would be noninferior to 12-month DAPT after implantation of drug-eluting stents...
  59. pmc Quantitative evaluation of high intensity signal on MIP images of carotid atherosclerotic plaques from routine TOF-MRA reveals elevated volumes of intraplaque hemorrhage and lipid rich necrotic core
    Kiyofumi Yamada
    Department of Radiology, University of Washington, Seattle, WA 98109 4325, USA
    J Cardiovasc Magn Reson 14:81. 2012
    Carotid intraplaque hemorrhage (IPH) and lipid rich necrotic core (LRNC) have been associated with accelerated plaque growth, luminal narrowing, future surface disruption and development of symptomatic events...
  60. doi Fibrinogen levels during trauma hemorrhage, response to replacement therapy, and association with patient outcomes
    C Rourke
    Trauma Sciences, Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK
    J Thromb Haemost 10:1342-51. 2012
    Low fibrinogen levels are known to occur in trauma. However, the extent of fibrinogen depletion during trauma hemorrhage, the response to replacement therapy and association with patient outcomes remain unclear.
  61. pmc Platelet granule secretion continuously prevents intratumor hemorrhage
    Benoit Ho-Tin-Noe
    Immune Disease Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    Cancer Res 68:6851-8. 2008
    ..microscopy revealed that platelet depletion led to a rapid destabilization of tumor vessels with intratumor hemorrhage starting as soon as 30 min after induction of thrombocytopenia...
  62. ncbi Atherosclerotic plaque rupture and intraplaque hemorrhage do not correlate with symptoms in carotid artery stenosis
    Jose Milei
    Instituto de Investigaciones Cardiologicas, Marcelo T de Alvear 2270, C1122AAJ, Buenos Aires, Argentina
    J Vasc Surg 38:1241-7. 2003
    ..The purpose of this study was to analyze the relation between the anatomy of the carotid plaques and the presence of symptoms in 281 carotid endarterectomy specimens...
  63. pmc Predicting early death in patients with traumatic bleeding: development and validation of prognostic model
    Pablo Perel
    Clinical Trials Unit, London School of Hygiene and Tropical Medicine, London WC1E 7HT, UK
    BMJ 345:e5166. 2012
    ..To develop and validate a prognostic model for early death in patients with traumatic bleeding...
  64. pmc A randomized comparison of two prophylaxis regimens and a paired comparison of on-demand and prophylaxis treatments in hemophilia A management
    L A Valentino
    Hemophilia and Thrombophilia Center, Rush University Medical Center, Chicago, IL, USA
    J Thromb Haemost 10:359-67. 2012
    ..Prophylaxis with factor (F)VIII is considered the optimal treatment for managing hemophilia A patients without inhibitors...
  65. ncbi Prasugrel versus clopidogrel in patients with acute coronary syndromes
    Stephen D Wiviott
    Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    N Engl J Med 357:2001-15. 2007
    ..Dual-antiplatelet therapy with aspirin and a thienopyridine is a cornerstone of treatment to prevent thrombotic complications of acute coronary syndromes and percutaneous coronary intervention...
  66. pmc CMR of microvascular obstruction and hemorrhage in myocardial infarction
    Katherine C Wu
    Division of Cardiology, Department of Medicine, Johns Hopkins Medical Institutions, 600 N Wolfe Street Carnegie 568, Baltimore, MD 21287, USA
    J Cardiovasc Magn Reson 14:68. 2012
    ..This review will summarize the pathophysiology of MO, current CMR approaches to diagnosis, clinical implications, and future directions needed for improving our understanding of this common clinical problem...
  67. doi Semuloparin for thromboprophylaxis in patients receiving chemotherapy for cancer
    Giancarlo Agnelli
    Division of Internal and Cardiovascular Medicine and Stroke Unit, Department of Internal Medicine, University of Perugia, Perugia, Italy
    N Engl J Med 366:601-9. 2012
    ..Patients receiving chemotherapy for cancer are at increased risk for venous thromboembolism. Limited data support the clinical benefit of antithrombotic prophylaxis...
  68. doi Battle casualty survival with emergency tourniquet use to stop limb bleeding
    John F Kragh
    US Army Institute of Surgical Research, Fort Sam Houston, Texas, USA
    J Emerg Med 41:590-7. 2011
    ..In a previous study conducted at a combat support hospital in Iraq, we reported the major lifesaving benefits of emergency tourniquets to stop bleeding in major limb trauma. Morbidity associated with tourniquet use was minor...
  69. pmc Mechanisms of vascular damage by hemorrhagic snake venom metalloproteinases: tissue distribution and in situ hydrolysis
    Cristiani Baldo
    Laboratorio de Imunopatologia, Instituto Butantan, Sao Paulo, Sao Paulo, Brasil
    PLoS Negl Trop Dis 4:e727. 2010
    ..Local hemorrhage is an important symptom of these accidents and is correlated with the action of snake venom metalloproteinases (..
  70. doi Regional citrate versus systemic heparin for anticoagulation in critically ill patients on continuous venovenous haemofiltration: a prospective randomized multicentre trial
    Gerd R Hetzel
    Department of Nephrology, Medical Faculty, Heinrich Heine University Dusseldorf, Germany
    Nephrol Dial Transplant 26:232-9. 2011
    ..However, data from randomized trials comparing citrate anticoagulation with systemic heparinization are very limited...
  71. pmc Comparison Evans Blue injection routes: Intravenous versus intraperitoneal, for measurement of blood-brain barrier in a mice hemorrhage model
    Anatol Manaenko
    Department of Physiology, Loma Linda University, Loma Linda, CA 92350, USA
    J Neurosci Methods 195:206-10. 2011
    Intracerebral hemorrhage is one of the most devastating subtypes of stroke, leaving survivors with severe neurological deficits...
  72. doi Plasma von Willebrand factor levels are an independent risk factor for adverse events including mortality and major bleeding in anticoagulated atrial fibrillation patients
    Vanessa Roldan
    Hematology and Medical Oncology Unit, Hospital Universitario Morales Meseguer, University of Murcia, Murcia, Spain
    J Am Coll Cardiol 57:2496-504. 2011
    ..The purpose of this study was to evaluate the prognostic value of plasma von Willebrand factor (vWF) levels and fibrin d-dimer in a large cohort of anticoagulated permanent atrial fibrillation (AF) patients...
  73. ncbi Systematic review and adjusted indirect comparison meta-analysis of oral anticoagulants in atrial fibrillation
    William L Baker
    University of Connecticut Schools of Pharmacy and Medicine, 263 Farmington Ave, Farmington, CT 06033, USA
    Circ Cardiovasc Qual Outcomes 5:711-9. 2012
    ..Direct comparative studies between agents are unavailable. Our objective was to conduct an adjusted indirect comparison meta-analysis between new oral agents in atrial fibrillation...
  74. ncbi Characterizing myocardial edema and hemorrhage using quantitative T2 and T2* mapping at multiple time intervals post ST-segment elevation myocardial infarction
    Mohammad I Zia
    Division of Cardiology, Schulich Heart Centre, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada
    Circ Cardiovasc Imaging 5:566-72. 2012
    Accurate characterization of the longitudinal trends of myocardial edema and hemorrhage has been previously limited by subjective qualitative methods...
  75. doi Using a 2D multibreath-hold susceptibility-weighted imaging to visualize intratumoral hemorrhage of hepatocellular carcinoma at 3T MRI: correlation with pathology
    Ruo Kun Li
    Department of Diagnostic Radiology, Zhongshan Hospital, Shanghai Medical School, Fudan University, Shanghai, China
    J Magn Reson Imaging 36:900-6. 2012
    To assess the value of 2D multibreath-hold susceptibility-weighted imaging (SWI) for visualizing intratumoral hemorrhage of hepatocellular carcinoma (HCC) and correlate with pathological results.
  76. doi Questions and answers on the use of dabigatran and perspectives on the use of other new oral anticoagulants in patients with atrial fibrillation. A consensus document of the Italian Federation of Thrombosis Centers (FCSA)
    V Pengo
    Clinical Cardiology, Thrombosis Center, Padova, Italy
    Thromb Haemost 106:868-76. 2011
    ..In this report members of the board of the Italian Federation of Thrombosis Centers (FCSA) answer some questions every clinician might be confronted with...
  77. doi Focused 2012 update of the Canadian Cardiovascular Society atrial fibrillation guidelines: recommendations for stroke prevention and rate/rhythm control
    Allan C Skanes
    Arrhythmia Service, University Hospital, University of Western Ontario, London, Ontario, Canada
    Can J Cardiol 28:125-36. 2012
    ..This report presents the details of the new recommendations, along with the background and rationale...
  78. doi Dabigatran etexilate for stroke prevention in patients with atrial fibrillation: resolving uncertainties in routine practice
    Menno V Huisman
    Department of Thrombosis and Haemostasis, Leiden University Medical Center, Leiden, The Netherlands
    Thromb Haemost 107:838-47. 2012
    ..In addition, cut-off values for different coagulation assay results associated with an increased risk of bleeding are given...
  79. doi Frequency of complications during EUS-guided drainage of pancreatic fluid collections in 148 consecutive patients
    Shyam Varadarajulu
    Department of Medicine, University of Alabama at Birmingham School of Medicine, Birmingham, Alabama, USA
    J Gastroenterol Hepatol 26:1504-8. 2011
    ..The aim of the present study was to evaluate the frequency of complications during endoscopic ultrasound (EUS)-guided drainage of pancreatic fluid collections (PFC), identify contributing factors, and report on management outcomes...
  80. doi A prospective study of an aggressive warfarin dosing algorithm to reach and maintain INR 2 to 3 after heart valve surgery
    Karina Meijer
    Division of Haemostasis and Thrombosis, Department of Haematology, University Medical Centre Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands
    Thromb Haemost 105:232-8. 2011
    ..We demonstrate an improvement of the level of anticoagulation control with the use of a condition-specific, aggressive algorithm, as compared to standard dosing, in patients after heart valve surgery...
  81. doi Aspirin plus clopidogrel versus aspirin alone after coronary artery bypass grafting: the clopidogrel after surgery for coronary artery disease (CASCADE) Trial
    Alexander Kulik
    Lynn Heart and Vascular Institute, University of Ottawa Heart Institute, Ontario, Canada
    Circulation 122:2680-7. 2010
    ....
  82. doi Association between carotid atherosclerosis plaque with high signal intensity on T1-weighted imaging and subsequent ipsilateral ischemic events
    Yoshitaka Kurosaki
    Department of Neurosurgery, The Tazuke Kofukai Medical Research Institute, Kitano Hospital, Osaka, Japan
    Neurosurgery 68:62-7; discussion 67. 2011
    An association between magnetic resonance imaging detection of intraplaque hemorrhage and the risk of cerebral ischemic events has been described. However, few studies have followed patients with intraplaque hemorrhage.
  83. doi In vivo MRI-based 3D mechanical stress-strain profiles of carotid plaques with juxtaluminal plaque haemorrhage: an exploratory study for the mechanism of subsequent cerebrovascular events
    Z Teng
    University Department of Radiology, University of Cambridge, Level 5, Box 218, Addenbrooke s Hospital, Hills Rd, Cambridge CB2 0QQ, UK
    Eur J Vasc Endovasc Surg 42:427-33. 2011
    ..Three-dimensional mechanical analysis was employed to represent the critical mechanical stress (P-CStress) and stretch (P-CStretch) within the plaque...
  84. ncbi Bleeding complications with warfarin use: a prevalent adverse effect resulting in regulatory action
    Diane K Wysowski
    Division of Drug Risk Evaluation, Food and Drug Administration, White Oak, Bldg 22, Room 3424, 10903 New Hampshire Ave, Silver Spring, MD 20993, USA
    Arch Intern Med 167:1414-9. 2007
    ..Warfarin sodium is widely used and causes bleeding; a review might suggest the need for regulatory action by the US Food and Drug Administration (FDA)...
  85. doi Quantitative tracking of edema, hemorrhage, and microvascular obstruction in subacute myocardial infarction in a porcine model by MRI
    Nilesh R Ghugre
    Imaging Research, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada
    Magn Reson Med 66:1129-41. 2011
    Pathophysiological responses after acute myocardial infarction include edema, hemorrhage, and microvascular obstruction along with cellular damage...
  86. doi Development and analysis of a collagen-based hemostatic adhesive
    Seung Hyuk Baik
    Department of Medical Engineering, Yonsei University College of Medicine, Seoul, Korea
    J Surg Res 164:e221-8. 2010
    ..Commercially available hemostatic-adhesive has the risk of disease transmission because it is derived from a plasma component. The purpose of this study is to manufacture a new hemostatic adhesive and evaluate its performances...
  87. doi Bleeding risk in 'real world' patients with atrial fibrillation: comparison of two established bleeding prediction schemes in a nationwide cohort
    J B Olesen
    Department of Cardiology, Copenhagen University Hospital Gentofte, Hellerup, Denmark
    J Thromb Haemost 9:1460-7. 2011
    ..We compared the performance of a new bleeding prediction scheme, HAS-BLED, with an older bleeding prediction scheme, HEMORR(2)HAGES, in a cohort of 'real-world' AF patients...
  88. doi Vital signs and estimated blood loss in patients with major trauma: testing the validity of the ATLS classification of hypovolaemic shock
    H R Guly
    Derriford Hospital, Plymouth PL6 8DH, UK
    Resuscitation 82:556-9. 2011
    ..The Advanced Trauma Life Support (ATLS) system classifies the severity of shock. The aim of this study is to test the validity of this classification...
  89. pmc Retrospective evaluation of the clinical and radiographic risk factors associated with severe pulmonary hemorrhage in first-line advanced, unresectable non-small-cell lung cancer treated with Carboplatin and Paclitaxel plus bevacizumab
    Alan B Sandler
    Vanderbilt University, Nashville, TN, USA
    J Clin Oncol 27:1405-12. 2009
    Severe (grade >or= 3) pulmonary hemorrhage (PH) in advanced non-small-cell lung cancer was observed in two prospective, randomized, phase II (N = 99) and phase III (N = 878) trials of bevacizumab plus carboplatin and paclitaxel...
  90. pmc Double-blind, placebo-controlled Phase II studies of the protease-activated receptor 1 antagonist E5555 (atopaxar) in Japanese patients with acute coronary syndrome or high-risk coronary artery disease
    Shinya Goto
    Department of Medicine Cardiology, Tokai University School of Medicine, Isehara, Kanagawa 259 1143, Japan
    Eur Heart J 31:2601-13. 2010
    ....
  91. pmc Prevention of VTE in nonorthopedic surgical patients: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines
    Michael K Gould
    Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
    Chest 141:e227S-77S. 2012
    ..VTE is a common cause of preventable death in surgical patients...
  92. pmc A new risk scheme to predict warfarin-associated hemorrhage: The ATRIA (Anticoagulation and Risk Factors in Atrial Fibrillation) Study
    Margaret C Fang
    Department of Medicine, University of California, San Francisco, San Francisco, California, USA
    J Am Coll Cardiol 58:395-401. 2011
    The purpose of this study was to develop a risk stratification score to predict warfarin-associated hemorrhage.
  93. doi Feasibility and safety of dabigatran versus warfarin for periprocedural anticoagulation in patients undergoing radiofrequency ablation for atrial fibrillation: results from a multicenter prospective registry
    Dhanunjaya Lakkireddy
    Division of Cardiovascular Diseases, Cardiovascular Research Institute, Mid America Cardiology, University of Kansas Hospital and Medical Center, 3901 Rainbow Boulevard, Kansas City, KS 66160 7200, USA
    J Am Coll Cardiol 59:1168-74. 2012
    ..The purpose of this study was to evaluate the feasibility and safety of periprocedural dabigatran during atrial fibrillation (AF) ablation...
  94. doi Detection of intraplaque hemorrhage by magnetic resonance imaging in symptomatic patients with mild to moderate carotid stenosis predicts recurrent neurological events
    Nishath Altaf
    Department of Vascular and Endovascular Surgery, Queen s Medical Centre, Nottingham, United Kingdom
    J Vasc Surg 47:337-42. 2008
    ..Intraplaque hemorrhage is associated with advanced atherosclerosis and can be detected in the carotid arteries by magnetic resonance ..
  95. pmc Antithrombotic therapy for atrial fibrillation: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines
    John J You
    Department of Medicine, McMaster University, Hamilton, ON, Canada
    Chest 141:e531S-75S. 2012
    ..We provide recommendations for antithrombotic treatment based on net clinical benefit for patients with AF at varying levels of stroke risk and in a number of common clinical scenarios...
  96. ncbi Pharmacogenetics of warfarin: current status and future challenges
    M Wadelius
    Department of Medical Sciences, Clinical Pharmacology, Uppsala University Hospital, Uppsala, Sweden
    Pharmacogenomics J 7:99-111. 2007
    ..Implementation of pre-prescription genotyping and individualized warfarin therapy represents an opportunity to minimize the risk of haemorrhage without compromising effectiveness...
  97. pmc A new grading system evaluating bleeding scale in filament perforation subarachnoid hemorrhage rat model
    Takashi Sugawara
    Department of Physiology, Loma Linda University, Loma Linda, CA 92350, United States
    J Neurosci Methods 167:327-34. 2008
    The endovascular perforation rodent model for experimental subarachnoid hemorrhage (SAH) studies is criticized for lack of control over bleeding...
  98. doi The use of dabigatran immediately after atrial fibrillation ablation
    Roger A Winkle
    Cardiovascular Medicine and Cardiac Arrhythmias, E Palo Alto, Sequoia Hospital, Redwood City, California, USA
    J Cardiovasc Electrophysiol 23:264-8. 2012
    ..Dabigatran is a new anticoagulant and may be useful after AF ablation to prevent thromboembolic events...
  99. ncbi Quality-of-life differences between prophylactic and on-demand factor replacement therapy in European haemophilia patients
    S Royal
    Research Triangle Institute, Washington, USA
    Haemophilia 8:44-50. 2002
    ..While these results suggest that health-related quality-of-life may be better for haemophilia patients treated prophylactically, future prospective studies that gather periodic quality-of-life data over time should be conducted...
  100. doi Bleeding risk in very old patients on vitamin K antagonist treatment: results of a prospective collaborative study on elderly patients followed by Italian Centres for Anticoagulation
    Daniela Poli
    Thrombosis Centre Department of Heart and Vessels, AOU Careggi, Florence, Italy
    Circulation 124:824-9. 2011
    ..We performed a large multicenter prospective observational study that enrolled very old patients to evaluate the quality of anticoagulation and the incidence of bleedings...
  101. pmc Critical mechanical conditions around neovessels in carotid atherosclerotic plaque may promote intraplaque hemorrhage
    Zhongzhao Teng
    University Department of Radiology, University of Cambridge, UK
    Atherosclerosis 223:321-6. 2012
    Intraplaque hemorrhage is an increasingly recognized contributor to plaque instability. Neovascularization of plaque is believed to facilitate the entry of inflammatory and red blood cells (RBC)...

Research Grants76

  1. Sutureless Laparoscopic Partial Nephrectomy Using Laser Tissue Welding: Preclinic
    Yasmin Wadia; Fiscal Year: 2013
    ..due to a) secondary infection, intra-abdominal abscess formation and septicemia, b) late bleeding or secondary hemorrhage or hematoma;c) urine leak;d) damage to the kidney parenchyma evident by compromised renal function or long term ..
  2. Clinical Development of Hemostatic Agent ClotFoam for Severe Hemorrhage
    Maja Nowakowski; Fiscal Year: 2013
    ..designed to arrest moderate to severe blood loss arising from intracavitary traumatic injury or intraoperative hemorrhage without compression, stitches or staples...
  3. Developing Physics-Based Virtual Simulation Technology for Natural Orifice Transl
    DANIEL BOUGERE JONES; Fiscal Year: 2013
    ..site in the gastric wall (gastrotomy closure);(5) prevention of infection;(6) control of intra-peritoneal hemorrhage;(7) developing novel instrumentation and (8) novel training regimens...
  4. Respiratory and autonomic plasticity following intermittent hypoxia
    JASON HAROLD MATEIKA; Fiscal Year: 2012
    ..Obstructive sleep apnea may also result in the development of hypertension, cerebral and subarachnoid hemorrhage, and ventricular arrhythmias...
  5. Effectiveness and Safety of Antithrombotic Strategies after Joint Replacement
    Elaine Hylek; Fiscal Year: 2013
    ..of the Institute for Health Metrics, we will pursue the following aims: 1) to determine incidence of VTE, major hemorrhage, and mortality within 90 days of hip or knee arthroplasty by age and sex, 2) to develop risk-prediction models ..
  6. Antenatal Betamethasone in Late Preterm Gestation Lambs
    SATYANARAYANA LAKSHMINRUSIMHA; Fiscal Year: 2010
    ..labor undoubtedly reduces a number of neonatal morbidities including respiratory distress and intraventricular hemorrhage. Given the promising results in infants >37 wk in a single study, research evaluating the pulmonary ..
  7. ANGIOTENSIN II SIGNAL TRANSDUCTION
    Bradford C Berk; Fiscal Year: 2012
    ..This defect is most apparent in the lung, characterized by hemorrhage in the parenchyma, increased alveolar spaces, decreased pulmonary microcirculation, and impaired basement ..
  8. MOLECULAR BIOLOGY OF HEMORRHAGIC SHOCK
    Timothy R Billiar; Fiscal Year: 2013
    ..Except for major head injury, hemorrhage/tissue trauma and its consequences are the most important causes of morbidity and mortality in these often young,..
  9. EEG Synchrony, perinatal risk and outcome: analysis of CHIME data
    PHILIP GEORGE GRIEVE; Fiscal Year: 2010
    ..antenatal corticosteroids, and mode of delivery;and 3) postnatal factors such as intraventricular hemorrhage, nosocomial infections and sepsis, days on mechanical ventilation, necrotizing enterocolitis and chronic lung ..
  10. Deacetylation of mitochondrial proteins protect neurons from ischemic injury
    Conrad Alano; Fiscal Year: 2013
    ..the only approved treatment for acute stroke is thrombolysis, which unfortunately increases the risk of brain hemorrhage and further brain injury...
  11. Stem Cell Based Therapy For Radiation Induced Gastrointestinal Syndrome
    Chandan Guha; Fiscal Year: 2010
    ..g., blood transfusion for hemorrhage or bone marrow transplantation for cytoablative damage...
  12. Role of ciliary proteins in endothelial cells morphogenesis
    Carlo Iomini; Fiscal Year: 2010
    ..cause of death in patients with ADPKD is due to cardiovascular complications such as hypertension, aneurysm, and hemorrhage of unclear pathogenesis...
  13. GI-Safer Formulation of Indomethacin for use in Preterm Neonates
    UPENDRA K MARATHI; Fiscal Year: 2010
    ..circuiting the pulmonary vasculature, leading to inadequate oxygenation, increasing the risk of intraventricular hemorrhage, bronchopulmonary dysplasia, and death...
  14. Rho-Modifying Cytotoxic Necrotizing Factor of E. coli
    ALISON DAVIS O'BRIEN; Fiscal Year: 2013
    ..cells in culture and a 3-D organoid model, and we recently found that Hly damages the uroepithelium and evokes hemorrhage in the bladders of mice 24 hours after intraurethral inoculation with CP9...
  15. BIOENGINEERING DESIGN OF ARTIFICIAL BLOOD
    Marcos Intaglietta; Fiscal Year: 2011
    ..MP4 is superior to blood in its ability to resuscitate animals from severe, uncontrolled hemorrhage, and it has been shown to be safe in human clinical trials...
  16. Research Center for Pharmacology &Drug Toxicology
    L Jackson Roberts; Fiscal Year: 2013
    ..of acetaminophen to inhibit hemoglobin redox cycling induced lipid peroxidation in patients with subarachnoid hemorrhage and the second project will evaluate the ability of acetaminophen to inhibit hemoglobin and myoglobin induced ..
  17. Heme Oxygenase Enzymes/Carbon Monoxide in Hepatic Dysfunction from hemorrhage
    BRIAN SCOTT ZUCKERBRAUN; Fiscal Year: 2013
    ..that inhaled CO can protect against the development of shock, inflammation, organ injury, and death from hemorrhage. Importantly, cells and tissues must be able to adjust metabolism and intracellular processes to accommodate for ..
  18. Effect of Inducible Antioxidants on Hemoglobin Toxicity
    Raymond F Regan; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Hemorrhage accompanies most significant brain trauma, and is the primary event in about 15% of strokes...
  19. Endothelial Progenitor Cells in Brain Arteriovenous Malformations
    Yongmei Chen; Fiscal Year: 2010
    ..The two study cohorts will be age and gender matched. Patients with embolization, radiosurgery, and hemorrhage will be excluded to avoid possible confounding effects...
  20. GI-Safer Formulation of Indomethacin for use in Preterm Neonates
    UPENDRA K MARATHI; Fiscal Year: 2013
    ..the pulmonary vasculature, leading to inadequate oxygenation, increasing the risk of intraventricular hemorrhage, bronchopulmonary dysplasia, and death...
  21. IMMUNOLOGICAL ASPECTS OF HEMORRHAGE
    Irshad H Chaudry; Fiscal Year: 2010
    ..and increased lethality from subsequent sepsis, in young males;but not in proestrus females following trauma-hemorrhage (T-H)...
  22. Impact of Temperature Profile on Outcome After Traumatic Brain Injury
    Lori Kennedy Madden; Fiscal Year: 2013
    ..motor score, pupillary reaction, hypoxia, hypotension, initial head CT classification, traumatic subarachnoid hemorrhage or epidural mass on CT, serum glucose, and serum hemoglobin) in predicting GOS- E...
  23. Ethnic/Racial Variation in Intracerebral Hemorrhage (ERICH)
    Daniel Woo; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Intracerebral hemorrhage (ICH) occurs when a blood vessel ruptures within the brain parenchyma leading to neurologic injury and frequently death...
  24. Harness Germinal Matrix Hemorrhage
    John H Zhang; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Germinal matrix hemorrhage (GMH) is defined as the rupture of immature blood vessels within the subependymal brain tissue. Occurring in approximately 3...
  25. Dichotomous Roles of Thrombin in Acetaminophen Hepatotoxicity
    ROBERT ANDREW ROTH; Fiscal Year: 2013
    ..Conversely, thrombin-mediated fibrin deposition limits later hepatocellular injury and hemorrhage. The deposition of fibrin is enhanced by the antifibrinolytic activity of plasminogen activator inhibitor-1 (PAI-..
  26. Autoantibodies in Preeclampsia: Pre-symptomatic markers and therapeutic targets
    Yang Xia; Fiscal Year: 2010
    ..liver and other vital organs and, if undetected or untreated, can lead to seizures (eclampsia), cerebral hemorrhage, failure in vital organs (i.e., kidney and heart) and death...
  27. Novel Glycosaminoglycan Ethers for Prevention of Metastasis
    Alana L Welm; Fiscal Year: 2011
    ..Nevertheless, translation into clinical cancer care has been stymied by potential side effects, including hemorrhage, from chronic administration of anticoagulant heparin and heparinoids...
  28. Chondroitin Sulfate Proteoglycan and Myelination in Intraventricular Hemorrhage
    Praveen Ballabh; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Intraventricular hemorrhage (IVH) in premature infants predisposes to white matter injury and subsequent cerebral palsy...
  29. Investigation of underlying mechanisms of sex differences in cerebral ischemia
    Chad S Siegel; Fiscal Year: 2010
    ..there is only one FDA-approved treatment for stroke;Tissue Plasminogen Activator, which can lead to severe brain hemorrhage in up to 7% of treated patients...
  30. (INTRODUCTION) MECHANISMS OF ACCLIMATIZATION: FETUS AND ADULT
    Lawrence D Longo; Fiscal Year: 2013
    ..For newborn they relate to altered cerebrovascular blood flow with intracerebral hemorrhage and pulmonary hypertension...
  31. RESEARCH CENTER FOR PHARMACOLOGY AND DRUG TOXICOLOGY
    L Jackson Roberts; Fiscal Year: 2010
    ..will evaluate the inhibition of lipid peroxidation by acetaminophen-based regimens in humans with subarachnoid hemorrhage. 4-hydroxynonenal is a bioactive lipid derived from the fragmentation of peroxidized polyunsaturated fatty acids ..
  32. Preventing lethal hemorrhagic fever caused by hantaviruses by preserving endothel
    ALAN L MUELLER; Fiscal Year: 2012
    ..internalization plays a role in the vascular leak associated with other hemorrhagic fevers including Dengue5 and hemorrhage-inducing agent anthrax6...
  33. Neurorestorative Strategy for Diabetic Peripheral Neuropathy
    Feng Qiao Li; Fiscal Year: 2013
    ..models of a variety of neurological disorders such as traumatic brain injury, spinal cord injury, subarachnoid hemorrhage and multiple sclerosis, implicating a therapeutic efficacy for these diseases...
  34. Surgical Indirect Revascularization For Symptomatic Intracranial Aterial Stenosis
    Nestor Gonzalez; Fiscal Year: 2013
    ..gradual development of collateral circulation where the brain demands it, deterring early hyper perfusion and hemorrhage. There has been no systematic trial exploring the use of EDAS in cases of symptomatic, non-moyamoya intracranial ..
  35. Mechanisms of trauma and hemorrhage-induced impairment of innate immunity
    Xiao Di Tan; Fiscal Year: 2013
    ..In this project, we will test our central hypothesis that trauma and hemorrhage induce down-regulation of Atg12 in lung epithelial cells, which in turn impairs Atg12-dependent innate defense ..
  36. Cerebral Artery Alpha1 Adrenergic and PKC Regulatory Mechanisms
    Lawrence D Longo; Fiscal Year: 2013
    ..This dysregulation may have serious consequences with intraventricular and germinal matrix hemorrhage with long-term neurological sequelae...
  37. Trauma and Hemorrhage-Induced Skeletal Muscle Insulin Resistance
    JOSEPH LOUIS MESSINA; Fiscal Year: 2013
    ..but are characteristic metabolic responses to infections and injuries such as surgery, burns, trauma and hemorrhage. Recent data suggests that intensive insulin treatment of ICU patients may reduce both morbidity and mortality ..
  38. Resuscitation using novel impedance threshold devices in pediatrics
    Keith G Lurie; Fiscal Year: 2013
    ..intrathoracic pressure ventilation resuscitation strategies often increase morbidity and mortality following hemorrhage. Augmenting negative intrathoracic pressure, even without fluid resuscitation, improves hemodynamic parameters ..
  39. Analysis of alphaVbeta8 Integrin In Gliomagenesis
    Joseph H McCarty; Fiscal Year: 2012
    ..gliomas develop severe blood vessel pathologies, including abnormal angiogenesis and associated edema and hemorrhage. Our working hypothesis is that reduced av[unreadable]8 integrin expression and function in tumor-initiating ..
  40. Modulating Secondary Damage Following Traumatic Brain Injury in the Child
    Stuart H Friess; Fiscal Year: 2013
    ..a clinically relevant pediatric porcine model of non-impact inertial head injury with subdural and subarachnoid hemorrhage, infarction, ischemia, and diffuse axonal injury, consistent with typical severe pediatric TBI...
  41. Pleiotropic Transcription Factors As Target For Intracerebral Hemorrhage Treatmen
    Jaroslaw A Aronowski; Fiscal Year: 2012
    ..provided by applicant): Given the failure of all clinical trials with cytoprotective therapy in intracerebral hemorrhage (ICH), new candidate therapy should have a pleiotropic effect which corresponds to the complex profile of ICH ..
  42. Keratin biomaterial-based fluid for trauma resuscitation
    LUKE BURNETT; Fiscal Year: 2010
    ..develop a keratin based resuscitation fluid that greatly improves outcomes for patients following treatment of hemorrhage. Inadequate fluid resuscitation technology has contributed to tens of thousands of lives lost and billions of ..
  43. PROTECTIVE EFFECTS OF DELAYED CORD CLAMPING IN VLBW INFANTS
    JUDITH SMITH MERCER; Fiscal Year: 2012
    ..trial of 72 VLBW infants born between 24 to 31 weeks gestation revealed fewer cases of intraventricular hemorrhage and late onset sepsis in infants who were randomized to delayed cord clamping (30 to 45 seconds) and lowered ..
  44. Resuscitation Outcomes Consortium (ROC) Regional Clinical Center-Seattle-King
    PETER JAMES KUDENCHUK; Fiscal Year: 2013
    ..for completion during the renewal period include, 1) immediate versus delayed intravenous fluid to decrease hemorrhage and subsequent reperfusion injury, 2) intravenous estrogen to decrease the magnitude of reperfusion injury, and ..
  45. Resuscitation Outcomes Consortium (ROC) Regional Clinical Centers-Milwaukee
    TOM PAUL AUFDERHEIDE; Fiscal Year: 2013
    ..for completion during the renewal period include, 1) immediate versus delayed intravenous fluid to decrease hemorrhage and subsequent reperfusion injury, 2) intravenous estrogen to decrease the magnitude of reperfusion injury, and ..
  46. Resuscitation Outcomes Consortium (ROC) Regional Clinical Center-Pittsburgh
    Clifton W Callaway; Fiscal Year: 2013
    ..for completion during the renewal period include, 1) immediate versus delayed intravenous fluid to decrease hemorrhage and subsequent reperfusion injury, 2) intravenous estrogen to decrease the magnitude of reperfusion injury, and ..
  47. Heat shock proteins in brain ischemia and stroke
    Midori A Yenari; Fiscal Year: 2013
    ..Brain ischemia frequently causes disruption of the blood brain barrier (BBB) leading to brain edema and hemorrhage which can complicate an already catastrophic illness...
  48. Improvement of Organ Function after Severe Hypovolemia
    Ping Wang; Fiscal Year: 2013
    ..We have shown that CIRP expression is upregulated in an animal model of hemorrhage and in surgical ICU patients...
  49. Translational studies of the Platelet Specific Receptor Trem Like Transcript (TLT
    A Valance Washington; Fiscal Year: 2013
    ..The overlap includes: prolonged bleeding times, delayed neutrophil migration, higher basal neutrophil counts and hemorrhage in response to the Shwartzman model of vasculitis...
  50. Role of P450 Eicosanoids in Delayed Microvascular Spasm Following Subarachnoid He
    DOMINIC AARON SILER; Fiscal Year: 2013
    ..A particularly devastating form of this illness, subarachnoid hemorrhage (SAH), represents 25% of life years lost among all forms of stroke due to the relatively young age of its ..
  51. MAINTENANCE OF ORGAN FUNCTION FOLLOWING INJURY
    Irshad H Chaudry; Fiscal Year: 2012
    ..are markedly depressed in males, but not in proestrus females (with high estrogen [E2] levels) after trauma-hemorrhage and resuscitation (T-H)...
  52. A NEW TECHNIQUE FOR TREATING HEMORRHAGIC SHOCK
    Sufan Chien; Fiscal Year: 2013
    ..In most western countries, trauma/hemorrhage is the leading cause of death up to the age of 40...
  53. Screening for allosteric modulators of the protease activated receptor 4
    Heidi E Hamm; Fiscal Year: 2013
    ..recently shown in Phase III clinical trials to increase clinically significant bleeding including intracranial hemorrhage. Because of PAR4's low affinity for thrombin, it is activated locally at the site of the 3-dimensional clot ..
  54. WHOLE SLIDE IMAGING SYSTEM FOR TRANSLATIONAL NEUROSCIENCE
    Jin Moo Lee; Fiscal Year: 2010
    ..on animal models of disease as diverse as Alzheimer's, multiple sclerosis, ischemic stroke, intracerebral hemorrhage, CNS infections, brain tumors, neurotrauma, prion diseases, and peripheral nerve injury...
  55. Transcutaneous vagus nerve stimulation in cerebral ischemia
    Ilknur Ay; Fiscal Year: 2013
    ..We will examine the effect of tPA - tVNS co-administration on risk of hemorrhage. We also will investigate the effect of tVNS on tPA's time window and efficacy using multi-modal MR imaging ..
  56. Biologic Evaluation of Liposome-Encapsulated Hemoglobin
    Vibhudutta Awasthi; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Severe hemorrhage is the leading cause of death among trauma victims, and is responsible for approximately 3 million deaths worldwide...
  57. Physiological Disturbances Associated with Neonatal Intraventricular Hemorrhage
    JEFFREY RADIN KAISER; Fiscal Year: 2012
    ..birth weight (ELBW;birth weight =1000 g) infants in the US develop severe (grades III and IV) intraventricular hemorrhage (IVH)...
  58. TRACE ELEMENT DYNAMICS IN THE VERTEBRATE EYE
    MARY C MCGAHAN; Fiscal Year: 2013
    ..Hypoxia, hemorrhage and inflammation significantly impact iron uptake storage, utilization and efflux...
  59. Autologous TGF-B-Modified HSC for Repair of Vasodegenerative Diabetic Retinopathy
    STEPHEN BARTELMEZ; Fiscal Year: 2009
    ..applicant): Diabetic retinopathy induces retinal vascular endothelial damage resulting in ischemia, edema, and hemorrhage. Current available treatments for diabetic retinopathy are focused on end-stages of the disease...
  60. Intracavitary Hemostatic Agent for Non-compressible Hemorrhage
    Martin Bluth; Fiscal Year: 2007
    unreadable] DESCRIPTION (provided by applicant): Hemorrhage resulting from traumatic injuries is a major cause of death in accidents, and the primary cause of death on the battlefield...
  61. Development and Validation of a Diagnostic Tool for Infant Head Injuries from Fal
    SUSAN SHEPS contact MARGULIES; Fiscal Year: 2010
    ..In Aim 1, biomechanical tolerances of extra-axial hemorrhage (subdural and subarachnoid hemorrhage) are determined by using a porcine computational model to simulate non-..
  62. WEIBEL PALADE BODY FORMATION AND ROLE IN HEMOSTASIS
    DENISA WAGNER; Fiscal Year: 2007
    ..during inflammation and the role of platelet and endothelial granules in vessel stability and prevention of hemorrhage[unreadable] ...
  63. Therapeutic for Intracerebral Hemorrhage
    Dale Christensen; Fiscal Year: 2009
    Intracerebral hemorrhage (ICH) is a devastating and relatively common disease affecting as many as 50,000 people annually in the United States alone...
  64. PREVENTION OF ULCER HEMORRHAGE BY H PYLORI ERADICATION
    Dennis Jensen; Fiscal Year: 2000
    ..pylori eradication plus full-dose H2RA maintenance in preventing recurrent ulcer hemorrhage and 2) ingestion of aspirin (ASA) or other non-steroidal anti-inflammatory drugs (NSAIDs) or recurrence of H...
  65. Ethyl Nitrite and Subarachnoid Hemorrhage
    Huaxin Sheng; Fiscal Year: 2009
    Cerebral vasospasm develops following subarachnoid hemorrhage (SAH), especially in patients with aneurysm rupture and causes major neurological and cognitive deficits and death...
  66. OBSTETRIC ANESTHESIA: TOCOLYSIS AND HEMORRHAGE
    DAVID CHESTNUT; Fiscal Year: 1993
    ..Obstetrician usually avoid ritodrine in patients at risk for hemorrhage, for fear of severe hypotension...
  67. CNS INJURY AND EDEMA RESEARCH CENTER
    Pak Chan; Fiscal Year: 2007
    ..unit, initiates oxidative stress and downstream signaling that cause neurovascular damage and intracerebral hemorrhage in the stroke brain. This Program consists of three interactive projects and two supporting cores...
  68. ESOPHAGEAL VARICES BY B-ADRENERGIC BLOCKERS
    Roberto Groszmann; Fiscal Year: 2003
    ..Gastroesophageal varices and variceal hemorrhage are a direct consequence of portal hypertension and account in large part for the high mortality of cirrhosis...
  69. Heme Oxygenase and Spinal Cord Injury
    Linda Noble; Fiscal Year: 2004
    ..Extracellular heme is derived from intraparenchymal hemorrhage and heme proteins released from dying cells...
  70. Carbon Monoxide to Prevent Circulatory Collapse
    Leo Otterbein; Fiscal Year: 2007
    DESCRIPTION (provided by applicant): Severe hemorrhage as a result of traumatic injury is major cause of death in the United Stated...
  71. STACHYBOTRYS INDUCED HEMORRHAGE IN THE DEVELOPING LUNG
    Dorr Dearborn; Fiscal Year: 2003
    Over the past 4 years in Cleveland, Ohio there have been 34 cases of pulmonary hemorrhage and hemosiderosis in young infants. To date, ten infants have died...