growth disorders

Summary

Summary: Deviations from the average values for a specific age and sex in any or all of the following: height, weight, skeletal proportions, osseous development, or maturation of features. Included here are both acceleration and retardation of growth.

Top Publications

  1. ncbi Worldwide timing of growth faltering: revisiting implications for interventions
    Cesar Gomes Victora
    Universidade Federal de Pelotas, Postgraduate Program in Epidemiology, Rua Marechal Deodoro 1160, 96020 220, Pelotas, RS, Brazil
    Pediatrics 125:e473-80. 2010
  2. pmc Developmental potential in the first 5 years for children in developing countries
    Sally Grantham-McGregor
    Centre for International Child Health, Institute of Child Health, University College London, UK
    Lancet 369:60-70. 2007
  3. ncbi Small for gestational age: short stature and beyond
    Paul Saenger
    Department of Pediatrics, Albert Einstein College of Medicine, Bronx, New York 10467, USA
    Endocr Rev 28:219-51. 2007
  4. ncbi Prevalence and trends of stunting among pre-school children, 1990-2020
    Mercedes de Onis
    Growth Assessment and Surveillance Unit, Department of Nutrition for Health and Development, World Health Organization, 20 Avenue Appia, 1211 Geneva 27, Switzerland
    Public Health Nutr 15:142-8. 2012
  5. pmc Mutations in the pre-replication complex cause Meier-Gorlin syndrome
    Louise S Bicknell
    Medical Research Council MRC Human Genetics Unit HGU, Institute of Genetics and Molecular Medicine, Western General Hospital, Edinburgh, UK
    Nat Genet 43:356-9. 2011
  6. pmc Multi-country analysis of the effects of diarrhoea on childhood stunting
    William Checkley
    Department of International Health, The Johns Hopkins University, Bloomberg School of Public Health, Baltimore, MD21205, USA
    Int J Epidemiol 37:816-30. 2008
  7. ncbi International Small for Gestational Age Advisory Board consensus development conference statement: management of short children born small for gestational age, April 24-October 1, 2001
    Peter A Lee
    Pennsylvania State University College of Medicine, Hershey Medical Center, Hershey, Pennsylvania
    Pediatrics 111:1253-61. 2003
  8. ncbi Worldwide timing of growth faltering: implications for nutritional interventions
    R Shrimpton
    Nutrition Unit, UNICEF, New York, New York, USA
    Pediatrics 107:E75. 2001
  9. ncbi Growth hormone insensitivity associated with a STAT5b mutation
    Eric M Kofoed
    Department of Pediatrics, Oregon Health and Science University, Portland, USA
    N Engl J Med 349:1139-47. 2003
  10. ncbi Long-term mortality after recombinant growth hormone treatment for isolated growth hormone deficiency or childhood short stature: preliminary report of the French SAGhE study
    Jean Claude Carel
    Department of Pediatric Endocrinology and Diabetology, Institut National de la Santé et de la Recherche Mdicale CIE5, Paris, France
    J Clin Endocrinol Metab 97:416-25. 2012

Detail Information

Publications268 found, 100 shown here

  1. ncbi Worldwide timing of growth faltering: revisiting implications for interventions
    Cesar Gomes Victora
    Universidade Federal de Pelotas, Postgraduate Program in Epidemiology, Rua Marechal Deodoro 1160, 96020 220, Pelotas, RS, Brazil
    Pediatrics 125:e473-80. 2010
    ..Our goal was to describe worldwide growth-faltering patterns by using the new World Health Organization (WHO) standards...
  2. pmc Developmental potential in the first 5 years for children in developing countries
    Sally Grantham-McGregor
    Centre for International Child Health, Institute of Child Health, University College London, UK
    Lancet 369:60-70. 2007
    ..These disadvantaged children are likely to do poorly in school and subsequently have low incomes, high fertility, and provide poor care for their children, thus contributing to the intergenerational transmission of poverty...
  3. ncbi Small for gestational age: short stature and beyond
    Paul Saenger
    Department of Pediatrics, Albert Einstein College of Medicine, Bronx, New York 10467, USA
    Endocr Rev 28:219-51. 2007
    ..Recent data, however, suggest that long-term treatment with GH does not increase the risk of type 2 diabetes mellitus and the metabolic syndrome in young adults born SGA...
  4. ncbi Prevalence and trends of stunting among pre-school children, 1990-2020
    Mercedes de Onis
    Growth Assessment and Surveillance Unit, Department of Nutrition for Health and Development, World Health Organization, 20 Avenue Appia, 1211 Geneva 27, Switzerland
    Public Health Nutr 15:142-8. 2012
    ..To quantify the prevalence and trends of stunting among children using the WHO growth standards...
  5. pmc Mutations in the pre-replication complex cause Meier-Gorlin syndrome
    Louise S Bicknell
    Medical Research Council MRC Human Genetics Unit HGU, Institute of Genetics and Molecular Medicine, Western General Hospital, Edinburgh, UK
    Nat Genet 43:356-9. 2011
    ..All of these genes encode components of the pre-replication complex, implicating defects in replication licensing as the cause of a genetic syndrome with distinct developmental abnormalities...
  6. pmc Multi-country analysis of the effects of diarrhoea on childhood stunting
    William Checkley
    Department of International Health, The Johns Hopkins University, Bloomberg School of Public Health, Baltimore, MD21205, USA
    Int J Epidemiol 37:816-30. 2008
    ..These observations are consistent with the hypothesis that a higher cumulative burden of diarrhoea increases the risk of stunting...
  7. ncbi International Small for Gestational Age Advisory Board consensus development conference statement: management of short children born small for gestational age, April 24-October 1, 2001
    Peter A Lee
    Pennsylvania State University College of Medicine, Hershey Medical Center, Hershey, Pennsylvania
    Pediatrics 111:1253-61. 2003
    ..To provide pediatric endocrinologists, general pediatricians, neonatologists, and primary care physicians with recommendations for the management of short children born small for gestational age (SGA)...
  8. ncbi Worldwide timing of growth faltering: implications for nutritional interventions
    R Shrimpton
    Nutrition Unit, UNICEF, New York, New York, USA
    Pediatrics 107:E75. 2001
    ..CONCLUSIONS: These findings highlight the need for prenatal and early life interventions to prevent growth failure...
  9. ncbi Growth hormone insensitivity associated with a STAT5b mutation
    Eric M Kofoed
    Department of Pediatrics, Oregon Health and Science University, Portland, USA
    N Engl J Med 349:1139-47. 2003
  10. ncbi Long-term mortality after recombinant growth hormone treatment for isolated growth hormone deficiency or childhood short stature: preliminary report of the French SAGhE study
    Jean Claude Carel
    Department of Pediatric Endocrinology and Diabetology, Institut National de la Santé et de la Recherche Mdicale CIE5, Paris, France
    J Clin Endocrinol Metab 97:416-25. 2012
    ..Little is known about the long-term health of subjects treated with GH in childhood, and Safety and Appropriateness of Growth hormone treatments in Europe (SAGhE) is a study addressing this question...
  11. ncbi Growth faltering in rural Gambian infants is associated with impaired small intestinal barrier function, leading to endotoxemia and systemic inflammation
    D I Campbell
    Medical Research Council, Keneba, The Gambia
    J Nutr 133:1332-8. 2003
    ..These data are consistent with the hypothesis of translocation of immunogenic lumenal macromolecules across a compromised gut mucosa, leading to stimulation of systemic immune/inflammatory processes and subsequent growth impairment...
  12. pmc Distinct methylation changes at the IGF2-H19 locus in congenital growth disorders and cancer
    Adele Murrell
    Department of Oncology, University of Cambridge, CRUK Cambridge Research Institute, Cambridge, United Kingdom
    PLoS ONE 3:e1849. 2008
    ..defects at IC1 are associated with aberrant activation or repression of IGF2, resulting in the congenital growth disorders Beckwith-Wiedemann (BWS) and Silver-Russell (SRS) syndromes, respectively...
  13. ncbi Long-term mortality and causes of death in isolated GHD, ISS, and SGA patients treated with recombinant growth hormone during childhood in Belgium, The Netherlands, and Sweden: preliminary report of 3 countries participating in the EU SAGhE study
    Lars Savendahl
    Division of Pediatric Endocrinology, Karolinska University Hospital Q2 08, SE 171 76 Stockholm, Sweden
    J Clin Endocrinol Metab 97:E213-7. 2012
    ..Recently released data from the French part of the European Union Safety and Appropriateness of GH treatments in Europe (EU SAGhE) study have raised concerns on the long-term safety of GH treatment...
  14. ncbi A pilot study to evaluate gene expression profiles in peripheral blood mononuclear cells (PBMCs) from children with GH deficiency and Turner syndrome in response to GH treatment
    Andrew J Whatmore
    Endocrine Sciences Research Group, University of Manchester, Oxford Road, Manchester, UK
    Clin Endocrinol (Oxf) 70:429-34. 2009
    ..TS is distinct and disease-specific. Further studies in larger cohorts will be required to evaluate whether GH-induced PBMCs gene expression patterns can predict responses to GH in a clinical setting...
  15. ncbi Health-related quality of life and cognitive functioning in pediatric short stature: comparison of growth-hormone-naïve, growth-hormone-treated, and healthy samples
    Matthew D Stephen
    Department of Pediatrics, Division of Endocrinology, The Children s Hospital at Scott and White and The University of Texas Health Science Center Houston, 2401 S 31st St, Temple, TX 76508, USA
    Eur J Pediatr 170:351-8. 2011
    ..0 Generic Score Scales and PedsQL™ Cognitive Functioning Scale in routine assessment of children with short stature in order to identify children at increased risk for impaired HRQOL and cognitive functioning...
  16. pmc Requirement of mouse BCCIP for neural development and progenitor proliferation
    Yi Yuan Huang
    The Cancer Institute of New Jersey, Department of Radiation Oncology, Robert Wood Johnson Medical School, New Brunswick, New Jersey, United States of America
    PLoS ONE 7:e30638. 2012
    ..These data suggest that BCCIP and its anti-replication stress functions are essential for normal neural development by maintaining an orderly proliferation of neural progenitors...
  17. ncbi Impact of anti-Giardia and anthelminthic treatment on infant growth and intestinal permeability in rural Bangladesh: a randomised double-blind controlled study
    Rie Goto
    Department of Biological Anthropology, University of Cambridge, Cambridge, UK
    Trans R Soc Trop Med Hyg 103:520-9. 2009
    ....
  18. ncbi Does zinc deficiency play a role in stunting among primary school children in NE Thailand?
    Rosalind S Gibson
    Department of Human Nutriton, University of Otago, Dunedin, New Zealand
    Br J Nutr 97:167-75. 2007
    ..Hence, zinc deficiency may be a factor limiting linear growth, especially among boys in NE Thailand, but more research is needed to establish whether other factors also play a role...
  19. ncbi Impact of intestinal permeability, inflammation status and parasitic infections on infant growth faltering in rural Bangladesh
    Rie Goto
    Department of Biological Anthropology, University of Cambridge, Cambridge, UK
    Br J Nutr 101:1509-16. 2009
    ..These findings suggest that rural Bangladeshi infants are being exposed to high levels of infection with concomitant gut damage and growth faltering...
  20. ncbi Mutations at a single codon in Mad homology 2 domain of SMAD4 cause Myhre syndrome
    Carine Le Goff
    Département de génétique, Unité INSERM U781, Universite Paris Descartes, Sorbonne Paris Cité, Hopital Necker Enfants Malades, Paris, France
    Nat Genet 44:85-8. 2012
    ..We also observed decreased expression of downstream TGF-β target genes, supporting the idea of impaired TGF-β-mediated transcriptional control in individuals with Myhre syndrome...
  21. ncbi The impact of infection and nutrition on gut function and growth in childhood
    P G Lunn
    Medical Research Council, Keneba, The Gambia
    Proc Nutr Soc 59:147-54. 2000
    ..More work is clearly required to elucidate these factors and to define interventions to prevent or treat the enteropathy...
  22. pmc Is malnutrition declining? An analysis of changes in levels of child malnutrition since 1980
    M de Onis
    Department of Nutrition for Health and Development, World Health Organization, Geneva, Switzerland
    Bull World Health Organ 78:1222-33. 2000
    ..Approaches to lower child malnutrition should be based on successful nutrition programmes and policies...
  23. pmc Germline mutations in the oncogene EZH2 cause Weaver syndrome and increased human height
    Katrina Tatton-Brown
    Division of Genetics and Epidemiology, Institute of Cancer Research, Sutton, UK
    Oncotarget 2:1127-33. 2011
    ..Our data establish EZH2 mutations as the cause of Weaver syndrome and provide further links between histone modifications and regulation of human growth...
  24. ncbi Height velocity targets from the national cooperative growth study for first-year growth hormone responses in short children
    Bert Bakker
    Genentech, Inc, 1 DNA Way, mailstop 454 B, South San Francisco, California 94080, USA
    J Clin Endocrinol Metab 93:352-7. 2008
    ..Although GH has been used to treat short stature in GH deficiency (GHD) and other conditions for more than 40 yr, criteria for satisfactorily defining targets for GH responsiveness have never been developed...
  25. pmc Loss of constitutive activity of the growth hormone secretagogue receptor in familial short stature
    Jacques Pantel
    INSERM, U654, Centre Hospitalier Universitaire Henri Mondor, Creteil, France
    J Clin Invest 116:760-8. 2006
    ....
  26. ncbi Inactivation of the Fto gene protects from obesity
    Julia Fischer
    Institute for Animal Developmental and Molecular Biology, Heinrich Heine University, Universitatsstr 1, D 40225 Dusseldorf, Germany
    Nature 458:894-8. 2009
    ..Taken together, these experiments provide, to our knowledge, the first direct demonstration that Fto is functionally involved in energy homeostasis by the control of energy expenditure...
  27. ncbi Diagnostic approach in children with short stature
    Wilma Oostdijk
    Department of Pediatrics, Leiden University Medical Center, Leiden, The Netherlands
    Horm Res 72:206-17. 2009
    ..Scientific evidence for the various components of laboratory screening is scarce, but accumulated experience and theoretical considerations have led to a list of investigations that may be considered until more evidence is available...
  28. ncbi Effects of early childhood psychosocial stimulation and nutritional supplementation on cognition and education in growth-stunted Jamaican children: prospective cohort study
    Susan P Walker
    Epidemiology Research Unit, Tropical Medicine Research Institute, University of the West Indies, Mona, Jamaica
    Lancet 366:1804-7. 2005
    ..Stunting in early childhood is associated with cognitive and educational deficits in late adolescence, which are reduced by stimulation at a young age...
  29. ncbi Idiopathic short stature: definition, epidemiology, and diagnostic evaluation
    J M Wit
    Department of Pediatrics, Leiden University Medical Center, Leiden, The Netherlands
    Growth Horm IGF Res 18:89-110. 2008
    ..ISS is the diagnostic group that remains after excluding known conditions in short children...
  30. ncbi Natriuretic peptides, their receptors, and cyclic guanosine monophosphate-dependent signaling functions
    Lincoln R Potter
    Department of Biochemistry, Molecular Biology, and Biophysics, 6 155 Jackson Hall, 321 Church Street SE, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Endocr Rev 27:47-72. 2006
    ..In this comprehensive review, the structure, function, regulation, and biological consequences of natriuretic peptides and their associated signaling proteins are described...
  31. ncbi Management of the child born small for gestational age through to adulthood: a consensus statement of the International Societies of Pediatric Endocrinology and the Growth Hormone Research Society
    P E Clayton
    University of Manchester, Manchester M13 9PL, United Kingdom
    J Clin Endocrinol Metab 92:804-10. 2007
    ..A meeting was convened to identify the key health issues facing a child born small for gestational age (SGA) and to propose management strategies...
  32. ncbi Effects of acute diarrhea on linear growth in Peruvian children
    William Checkley
    Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Am J Epidemiol 157:166-75. 2003
    ..In contrast, diarrhea after 6 months of age showed transient effects. Study results indicate that diarrhea control, especially during the first 6 months of life, is likely to improve linear growth in Peruvian children...
  33. ncbi Auxological computer based network for early detection of disorders of growth and weight attainment
    Eberhard Keller
    Children s Hospital, University of Leipzig, Germany
    J Pediatr Endocrinol Metab 15:149-56. 2002
    ..and pediatric endocrinologists in Leipzig have been collaborating closely to achieve early detection of growth disorders. As a result of this collaboration a data-bank was established in September 1998 into which height and weight ..
  34. ncbi Diagnosis and management of growth hormone deficiency in childhood and adolescence--part 2: growth hormone treatment in growth hormone deficient children
    Toshiaki Tanaka
    Department of Endocrinology and Metabolism, National Children s Medical Research Center, Tokyo, Japan
    Growth Horm IGF Res 12:323-41. 2002
  35. ncbi Insulin growth factor-based dosing of growth hormone therapy in children: a randomized, controlled study
    Pinchas Cohen
    Department of Pediatric Endocrinology, Mattel Children s Hospital at UCLA, 10833 Le Conte Avenue, MDCC 22 315, Los Angeles, California 90095, USA
    J Clin Endocrinol Metab 92:2480-6. 2007
    ..Weight-based dosing of GH is the standard of care for short children, although IGF-I is thought to be the main mediator of GH actions on growth...
  36. ncbi Growth failure in early life: an important manifestation of Turner syndrome
    Michael L Davenport
    Department of Pediatrics, Division of Pediatric Endocrinology, School of Public Health, The University of North Carolina at Chapel Hill, NC 27599, USA
    Horm Res 57:157-64. 2002
    ..Traditional concepts of growth failure in TS should be revised. Physicians should consider the diagnosis of TS in any girl with unexplained failure to thrive or short stature, even in the first 3 years of life...
  37. ncbi Linear growth retardation and cognition
    Sally Grantham-McGregor
    Centre for International Child Health, Institute of Child Health, WC1N 1EH, London, UK
    Lancet 359:542. 2002
  38. ncbi Aberrant CpG methylation of the imprinting control region KvDMR1 detected in assisted reproductive technology-produced calves and pathogenesis of large offspring syndrome
    Noboru Hori
    Ishikawa Prefectural Livestock Research Center, Hodatsushimizu, Ishikawa 929 1325, Japan
    Anim Reprod Sci 122:303-12. 2010
    ..Our findings provide strong evidence for a role of altered imprinting control in the development of LOS in bovines...
  39. ncbi Nutritional stunting in Egypt: which nutrient is responsible?
    S A Ibrahim
    Department of Research and Field Study, Nutrition Institute, Cairo, Egypt
    East Mediterr Health J 8:272-80. 2002
    ..Serum zinc levels were also lower in the stunted group but not significantly so. We conclude that several nutrient deficiencies occur simultaneously in stunted children and all of them may be responsible for stunting...
  40. pmc The PERK eukaryotic initiation factor 2 alpha kinase is required for the development of the skeletal system, postnatal growth, and the function and viability of the pancreas
    Peichuan Zhang
    Department of Biology, The Pennsylvania State University, University Park, Pennsylvania 16802, USA
    Mol Cell Biol 22:3864-74. 2002
    ..The skeletal, pancreatic, and growth defects are similar to those seen in human Wolcott-Rallison syndrome...
  41. ncbi Short stature and obesity: positive association in adults but inverse association in children and adolescents
    Anja Bosy-Westphal
    Institut fur Humanernahrung und Lebensmittelkunde, Christian Albrechts University, Düsternbrooker Weg 17, Kiel, Germany
    Br J Nutr 102:453-61. 2009
    ..In conclusion, short stature is associated with an increased risk of obesity in adults. Cardiometabolic risk in short stature is not explained by an adverse body composition...
  42. ncbi Continuation of linear growth failure and its association with cognitive ability are not dependent on initial length-for-age: a longitudinal study from 6 months to 11 years of age
    Y B Cheung
    Scientific Development Division, Singapore Clinical Research Institute, Biopolis, Singapore
    Acta Paediatr 99:1719-23. 2010
    ..To examine linear growth and its association with cognitive ability at age 11 years among full-term singletons with varying degree of stunting or without stunting at age 6 months...
  43. ncbi Effect of water and sanitation on childhood health in a poor Peruvian peri-urban community
    William Checkley
    Department of International Health, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA
    Lancet 363:112-8. 2004
    ..Inadequate water and sanitation adversely affect the health of children in developing countries. We aimed to assess the effects of water and sanitation on childhood health in a birth cohort of Peruvian children...
  44. ncbi Inadequate feeding practices and impaired growth among children from subsistence farming households in Sidama, Southern Ethiopia
    Rosalind S Gibson
    Department of Human Nutrition, University of Otago, New Zealand
    Matern Child Nutr 5:260-75. 2009
    ..In conclusion, interventions that address the WHO guiding principles for complementary feeding practices and behaviours, as well as prenatal influences on growth, are urgently required in this setting...
  45. pmc Meier-Gorlin syndrome genotype-phenotype studies: 35 individuals with pre-replication complex gene mutations and 10 without molecular diagnosis
    Sonja A de Munnik
    Department of Human Genetics 836, Institute for Genetic and Metabolic Disease, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Eur J Hum Genet 20:598-606. 2012
    ..No other clear genotype-phenotype association was observed. Growth hormone and estrogen treatment may be of some benefit, respectively, to growth retardation and breast hypoplasia, though further studies in this patient group are needed...
  46. ncbi Effect of growth hormone therapy and puberty on bone and body composition in children with idiopathic short stature and growth hormone deficiency
    Wolfgang Hogler
    Institute of Endocrinology and Diabetes, The Children s Hospital at Westmead, Locked Bag 4001, NSW 2145, Sydney, Australia
    Bone 37:642-50. 2005
    ..Growth hormone had great effects on the growth plate and body composition with subsequent gains in height, LTM, bone turnover, and bone mass accrual, but no benefit for volumetric bone density over 2 years...
  47. ncbi Reversibility of growth stunting in early onset anorexia nervosa: a prospective study
    Eleni Lantzouni
    Division of Adolescent Medicine, Schneider Children s Hospital, North Shore Long Island Jewish Health System, Albert Einstein College of Medicine, New Hyde Park, New York, USA
    J Adolesc Health 31:162-5. 2002
    ..To evaluate the growth of premenarchal patients with anorexia nervosa...
  48. ncbi Slowing of growth in height and weight on stimulants: a characteristic pattern
    A Poulton
    Department of Paediatrics, Nepean Hospital, Penrith, New South Wales, Australia
    J Paediatr Child Health 39:180-5. 2003
    ..The aims of the present study were to describe the growth pattern of children starting stimulant medication and to analyse the changes over time in height, weight and height velocity in a cohort of treated patients...
  49. pmc The prevalence of stunting, overweight and obesity, and metabolic disease risk in rural South African children
    Elizabeth W Kimani-Murage
    MRC Wits Rural Public Health and Health Transitions Research Unit Agincourt, School of Public Health, Faculty of Health Sciences, University of Witwatersrand, Johannesburg, South Africa
    BMC Public Health 10:158. 2010
    ..This study aimed to investigate the prevalence and patterns of stunting and overweight/obesity, and hence risk for metabolic disease, in a group of children and adolescents in rural South Africa...
  50. pmc Time-independent maternal and infant factors and time-dependent infant morbidities including HIV infection, contribute to infant growth faltering during the first 2 years of life
    Aimee L Webb
    Department of Anthropology, Laboratory for the Study of Constraints on Child Nutrition and Care, University of Toronto, Toronto, ON, Canada
    J Trop Pediatr 55:83-90. 2009
    ..In conclusion, maternal schooling, immunological status and infant infections are important predictors of early growth in children born to HIV-positive women...
  51. ncbi Mutations of the growth hormone receptor in children with idiopathic short stature. The Growth Hormone Insensitivity Study Group
    A D Goddard
    Department of Molecular Biology, Genentech, Inc, South San Francisco, CA 94080, USA
    N Engl J Med 333:1093-8. 1995
    ....
  52. pmc Array-based comparative genomic hybridization identifies a high frequency of copy number variations in patients with syndromic overgrowth
    Valerie Malan
    Departement de Génétique et INSERM U781, Universite Paris Descartes, Hopital Necker Enfants Malades, Paris, France
    Eur J Hum Genet 18:227-32. 2010
    ....
  53. ncbi Growth of infants born to HIV-infected women in South Africa according to maternal and infant characteristics
    Kartik K Venkatesh
    Department of Community Health, Alpert Medical School, Brown University, Providence, RI, USA
    Trop Med Int Health 15:1364-74. 2010
    ..To evaluate growth parameters assessed by weight and length in HIV-infected and HIV-uninfected infants born to HIV-infected mothers in South Africa from birth to 6 months of age...
  54. ncbi Bone mineral density and body composition in adolescents with childhood-onset growth hormone deficiency
    Annemieke M Boot
    Department of Pediatrics, Division of Pediatric Endocrinology, University Medical Center Groningen, The Netherlands
    Horm Res 71:364-71. 2009
    ..The aim of the present study was to evaluate bone mineral density (BMD) and body composition of patients with childhood-onset growth hormone (GH) deficiency (GHD) treated with GH during the transition period...
  55. ncbi Growth of preterm and full-term children aged 0-4 years: integrating median growth and variability in growth charts
    Inger F A Bocca-Tjeertes
    Division of Neonatology, Department of Pediatrics, University Medical Center Groningen, Groningen, The Netherlands
    J Pediatr 161:460-465.e1. 2012
    ....
  56. ncbi Deletions of the homeobox gene SHOX (short stature homeobox) are an important cause of growth failure in children with short stature
    Gudrun A Rappold
    Institute of Human Genetics, University of Heidelberg, 69120 Heidelberg, Germany
    J Clin Endocrinol Metab 87:1402-6. 2002
    ....
  57. pmc A simple chart to identify non-familial short stature
    T J Cole
    Department of Epidemiology and Public Health, Institute of Child Health, London WC1N 1EH, UK
    Arch Dis Child 82:173-6. 2000
    ..To develop a chart to identify non-familial short stature...
  58. ncbi Stunting of growth as a major feature of anorexia nervosa in male adolescents
    Dalit Modan-Moses
    Pediatric Endocrinology Service, Chaim Sheba Medical Center, Tel Hashomer, Israel
    Pediatrics 111:270-6. 2003
    ..To assess growth retardation in male adolescent patients who have a diagnosis of anorexia nervosa (AN) and the effect of weight restoration on catch-up growth...
  59. ncbi Prediction of response to growth hormone treatment in short children born small for gestational age: analysis of data from KIGS (Pharmacia International Growth Database)
    Michael B Ranke
    Sektion Pädiatrische Endokrinologie, Universitatsklinikum Tubingen, Eberhard Karls Universitat, D 72076 Tubingen, Germany
    J Clin Endocrinol Metab 88:125-31. 2003
    ..Furthermore, this model can be used to provide patients with a realistic expectation of treatment and may help to identify compliance problems or other underlying causes of treatment failure...
  60. ncbi Interpretative difficulties with growth hormone provocative retesting in childhood-onset growth hormone deficiency
    J Van den Broeck
    Dutch Growth Foundation, Rotterdam, The Netherlands
    Horm Res 51:1-9. 1999
    ..Moreover, it is possible that 'normal values' increase with age. Other determinants of normal peak values may also change from childhood to adulthood and contribute to 'normalization'...
  61. ncbi Intestinal inflammation measured by fecal neopterin in Gambian children with enteropathy: association with growth failure, Giardia lamblia, and intestinal permeability
    David I Campbell
    School of Clinical and Medical Sciences, Sir James Spence Institute of Child Health, University of Newcastle upon Tyne, United Kingdom
    J Pediatr Gastroenterol Nutr 39:153-7. 2004
    ..Secondary outcome measures tested the associations between Giardia lamblia infestation, fecal neopterin and lactulose mannitol absorption ratio(L:M), a measure of intestinal permeability...
  62. ncbi Determinants of aflatoxin exposure in young children from Benin and Togo, West Africa: the critical role of weaning
    Y Y Gong
    Molecular Epidemiology Unit, Epidemiology and Health Services Research, School of Medicine, University of Leeds, Leeds, UK
    Int J Epidemiol 32:556-62. 2003
    ..Dietary exposure to high levels of the fungal toxin, aflatoxin, occurs in West Africa, where long-term crop storage facilitates fungal growth...
  63. ncbi Recombinant human growth hormone for the treatment of growth disorders in children: a systematic review and economic evaluation
    A Takeda
    Southampton Health Technology Assessments Centre, Southampton, UK
    Health Technol Assess 14:1-209, iii-iv. 2010
    ....
  64. pmc Recurrent reciprocal deletions and duplications of 16p13.11: the deletion is a risk factor for MR/MCA while the duplication may be a rare benign variant
    F D Hannes
    Center for Human Genetics, Herestraat 49, 3000 Leuven, Belgium
    J Med Genet 46:223-32. 2009
    ..Genomic disorders are often caused by non-allelic homologous recombination between segmental duplications. Chromosome 16 is especially rich in a chromosome-specific low copy repeat, termed LCR16...
  65. pmc Boys are more stunted than girls in sub-Saharan Africa: a meta-analysis of 16 demographic and health surveys
    Henry Wamani
    Centre for International Health, University of Bergen, Armauer Hansen Building, N 5021 Bergen, Norway
    BMC Pediatr 7:17. 2007
    ..This study examined whether there are systematic sex differences in stunting rates in children under-five years of age, and how the sex differences in stunting rates vary with household socio-economic status...
  66. ncbi Height at start, first-year growth response and cause of shortness at birth are major determinants of adult height outcomes of short children born small for gestational age and Silver-Russell syndrome treated with growth hormone: analysis of data from KIG
    Michael B Ranke
    Paediatric Endocrinology Section, University Children s Hospital, Tubingen, Germany
    Horm Res Paediatr 74:259-66. 2010
    ..There is limited information about adult height (AH) outcomes and the factors influencing outcomes of growth hormone (GH) therapy in short children born small for gestational age (SGA)...
  67. pmc Is economic growth associated with reduction in child undernutrition in India?
    Malavika A Subramanyam
    Center for Integrative Approaches to Health Disparities, School of Public Health, University of Michigan, Ann Arbor, MI, USA
    PLoS Med 8:e1000424. 2011
    ..Economic growth is widely perceived as a major policy instrument in reducing childhood undernutrition in India. We assessed the association between changes in state per capita income and the risk of undernutrition among children in India...
  68. ncbi Children who recover from early stunting and children who are not stunted demonstrate similar levels of cognition
    Benjamin T Crookston
    Department of Family and Preventive Medicine, University of Utah, Salt Lake City, UT 84108, USA
    J Nutr 140:1996-2001. 2010
    ....
  69. ncbi Observed and predicted growth responses in prepubertal children with growth disorders: guidance of growth hormone treatment by empirical variables
    Michael B Ranke
    Pediatric Endocrinology Section, University Children s Hospital, Eberhard Karls University, Hoppe Seyler Strasse 1, Tuebingen D 72076, Germany
    J Clin Endocrinol Metab 95:1229-37. 2010
    ..Information about the expected growth response of children to GH therapy is currently inadequate...
  70. pmc Genotype-phenotype associations in Sotos syndrome: an analysis of 266 individuals with NSD1 aberrations
    Katrina Tatton-Brown
    Section of Cancer Genetics, Institute of Cancer Research, Sutton, Surrey, United Kingdom
    Am J Hum Genet 77:193-204. 2005
    ..005) to carry missense mutations, suggesting that the underlying NSD1 mutational mechanism in Sotos syndrome may influence reproductive fitness...
  71. ncbi Prevalence and predictors of underweight, stunting, and wasting among children aged 5 and under in western Kenya
    Emily Bloss
    School of Public Health and Tropical Medicine, Tulane University, New Orleans, LA 70112, USA
    J Trop Pediatr 50:260-70. 2004
    ..Emphasis should be placed on current immunization, prolonging exclusive breastfeeding, and improving access to nutrient-rich foods among adopted children and their families via community-based nutrition interventions...
  72. ncbi A growth-deficiency phenotype in heterozygous mice carrying an insulin-like growth factor II gene disrupted by targeting
    T M DeChiara
    Department of Genetics and Development, Columbia University, New York, New York 10032
    Nature 345:78-80. 1990
    ..The effect of the mutation was exerted during the embryonic period. These results provide the first direct evidence for a physiological role of IGF-II in embryonic growth...
  73. ncbi Growth and pubertal development in children and adolescents: effects of diet and physical activity
    A D Rogol
    University of Virginia Health Sciences Center Charlottesville, USA
    Am J Clin Nutr 72:521S-8S. 2000
    ....
  74. ncbi Incidence of diabetes mellitus and impaired glucose tolerance in children and adolescents receiving growth-hormone treatment
    W S Cutfield
    Department of Paediatrics, University of Auckland, New Zealand
    Lancet 355:610-3. 2000
    ..We undertook a retrospective analysis of data from an international pharmacoepidemiological survey of children treated with GH to find out the incidence of impaired glucose tolerance and types 1 and 2 diabetes mellitus...
  75. pmc SnoRNA Snord116 (Pwcr1/MBII-85) deletion causes growth deficiency and hyperphagia in mice
    Feng Ding
    Department of Genetics, Stanford University, Stanford, California, USA
    PLoS ONE 3:e1709. 2008
    ..Prolonged mealtime and increased circulating ghrelin indicate a defect in meal termination mechanism. Snord116del mice, the first snoRNA deletion animal model, reveal a novel role for a non-coding RNA in growth and feeding regulation...
  76. ncbi Wolcott-Rallison syndrome: a clinical and genetic study of three children, novel mutation in EIF2AK3 and a review of the literature
    S Iyer
    Department of Endocrinology, Birmingham Children s Hospital, Birmingham, UK
    Acta Paediatr 93:1195-201. 2004
    ..So far, 17 children have been described in the world literature. Recently, mutations in the gene encoding EIF2AK3 have been shown to segregate with the syndrome in three affected families...
  77. ncbi Monitoring of concordance in growth hormone therapy
    R R Kapoor
    Department of Paediatrics, Addenbrooke s Hospital, University of Cambridge, Cambridge, UK
    Arch Dis Child 93:147-8. 2008
    ..Lower concordance was associated with longer duration on GH therapy (p<0.005), lack of choice of delivery device (p<0.005) and short prescription durations (p<0.005), and predicted lower height velocities (p<0.05)...
  78. ncbi Duplications of chromosome 11p15 of maternal origin result in a phenotype that includes growth retardation
    Andrew M Fisher
    Wessex Regional Genetics Laboratory, Salisbury District Hospital, Salisbury, SP2 8BJ, UK
    Hum Genet 111:290-6. 2002
    ..5 years and Patient 2 showed breast development in infancy. Both patients shared some dysmorphological features, namely short palpebral fissures, a prominent nasal tip, a short philtrum and 5th finger clinodactyly...
  79. ncbi SHH mutation is associated with solitary median maxillary central incisor: a study of 13 patients and review of the literature
    L Nanni
    Department of Pediatrics, The Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Am J Med Genet 102:1-10. 2001
    ..Our results suggest that this mutation may be specific for the SMMCI phenotype since it has not been found in the HPE population or in normal controls. Published 2001 Wiley-Liss, Inc...
  80. pmc Dietary aflatoxin exposure and impaired growth in young children from Benin and Togo: cross sectional study
    Y Y Gong
    Molecular Epidemiology Unit, Epidemiology and Health Services Research, School of Medicine, University of Leeds, Leeds LS2 9JT
    BMJ 325:20-1. 2002
  81. ncbi Growth in early childhood in a cohort of children born to HIV-1-infected women from Durban, South Africa
    R Bobat
    Department of Paediatrics, Nelson R Mandela School of Medicine, University of Natal, Private Bag 7, Congella 4013, South Africa
    Ann Trop Paediatr 21:203-10. 2001
    ..Early nutritional intervention might help prevent early progression or death in HIV-infected children, particularly in developing countries without access to anti-retroviral therapy in state hospitals...
  82. pmc Towards evidence based referral criteria for growth monitoring
    S van Buuren
    Dept of Statistics, TNO Prevention and Health, Leiden, Netherlands
    Arch Dis Child 89:336-41. 2004
    ..To evaluate the performance of growth monitoring in detecting diseases. Turner's syndrome (TS) is taken as the target disease...
  83. pmc Deletion of the MBII-85 snoRNA gene cluster in mice results in postnatal growth retardation
    Boris V Skryabin
    Institute of Experimental Pathology ZMBE, University of Munster, Munster, Germany
    PLoS Genet 3:e235. 2007
    ..This is the first example in a multicellular organism of genetic deletion of a C/D box snoRNA gene resulting in a pronounced phenotype...
  84. ncbi Mutations in origin recognition complex gene ORC4 cause Meier-Gorlin syndrome
    Duane L Guernsey
    Department of Pathology, Dalhousie University, Halifax, Nova Scotia, Canada
    Nat Genet 43:360-4. 2011
    ..This is the first report, to our knowledge, of a germline mutation in any gene of the origin recognition complex in a vertebrate organism...
  85. pmc Rate of head circumference growth as a function of autism diagnosis and history of autistic regression
    Sara Jane Webb
    Department of Psychiatry and Behavioral Sciences, University of Washington Autism Center, University of Washington, Seattle, WA 98195, USA
    J Child Neurol 22:1182-90. 2007
    ..Findings from this study suggest that the aberrant growth is present in the first year of life and precedes the onset and diagnosis in children with autism spectrum disorder with and without a history of autistic regression...
  86. ncbi Risk factors for stunting among under-fives in Libya
    Adel El Taguri
    Hopital Necker Enfants Malades, 149 rue de Sevres, F 75743 Paris Cedex 15, France
    Public Health Nutr 12:1141-9. 2009
    ..Stunting is a chronic condition reflecting poor nutrition and health. Our aim was to ascertain major predictors of stunting in children <5 years old in Libya...
  87. ncbi Mutations in ORC1, encoding the largest subunit of the origin recognition complex, cause microcephalic primordial dwarfism resembling Meier-Gorlin syndrome
    Louise S Bicknell
    Medical Research Council MRC Human Genetics Unit HGU, Institute for Genetics and Molecular Medicine, Western General Hospital, Edinburgh, UK
    Nat Genet 43:350-5. 2011
    ..These findings establish a novel mechanism for the pathogenesis of microcephalic dwarfism and show a surprising but important developmental impact of impaired origin licensing...
  88. ncbi Implications of the prevalence of stunting, overweight and obesity amongst South African primary school children: a possible nutritional transition?
    C C Jinabhai
    Department of Community Health, Nelson R Mandela School of Medicine, University of Natal, Durban, South Africa
    Eur J Clin Nutr 57:358-65. 2003
    ..To investigate the relationship between stunting and levels of overweight/obesity among South African school children, using two definitions of overweight and obesity, based on the WHO and International Obesity Task Force (IOTF) criteria...
  89. ncbi Pseudoautosomal deletions encompassing a novel homeobox gene cause growth failure in idiopathic short stature and Turner syndrome
    E Rao
    Institute of Human Genetics, Heidelberg University, Germany
    Nat Genet 16:54-63. 1997
    ..Our data suggest an involvement of SHOX in idiopathic growth retardation and in the short stature phenotype of Turner syndrome patients...
  90. ncbi Use of multiplex ligation-dependent probe amplification increases the detection rate for 11p15 epigenetic alterations in Silver-Russell syndrome
    T Eggermann
    Institute of Human Genetics, RWTH Aachen, Aachen, Germany
    Clin Genet 73:79-84. 2008
    ..Considering maternal UPD7 and chromosomal aberrations, (epi)genetic alterations now account for more than 50% of SRS patients. In summary, MLPA represents an easy, low cost and reliable system in the molecular diagnostics of SRS...
  91. ncbi Premature aging in mice deficient in DNA repair and transcription
    Jan de Boer
    Medical Genetics Center, Department of Cell Biology and Genetics, Center for Biomedical Genetics, Erasmus University, 3000 DR Rotterdam, Netherlands
    Science 296:1276-9. 2002
    ..We hypothesize that aging in TTD mice is caused by unrepaired DNA damage that compromises transcription, leading to functional inactivation of critical genes and enhanced apoptosis...
  92. ncbi Improvements in behaviour and self-esteem following growth hormone treatment in short prepubertal children
    John Eric Chaplin
    Goteborg Pediatric Growth Research Center, Institute of Clinical Science, the Sahlgrenska Academy at University of Gothenburg, Goteborg, Sweden
    Horm Res Paediatr 75:291-303. 2011
    ..To evaluate effects of growth hormone (GH) treatment on behaviour and psychosocial characteristics in short-stature children...
  93. ncbi Growth hormone and bone health
    Marie Bex
    Laboratory for Experimental Medicine and Endocrinology, Catholic University of Leuven, Gasthuisberg, Leuven, Belgium
    Horm Res 60:80-6. 2003
    ..GH therapy for other bone disorders not associated with primary GHD needs further study but may well be beneficial because of its positive effects on the bone remodelling cycle...
  94. ncbi Constitutional delay of growth and puberty: from presentation to final height
    Sukran Poyrazoglu
    Department of Growth and Development and Pediatric Endocrinology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey
    J Pediatr Endocrinol Metab 18:171-9. 2005
    ....
  95. ncbi Recessive isolated growth hormone deficiency and mutations in the ghrelin receptor
    Jacques Pantel
    INSERM, U933, 75011 Paris, France
    J Clin Endocrinol Metab 94:4334-41. 2009
    ..Recently in several patients, a missense mutation (p.A204E) resulting in a complete loss of GHSR constitutive activity has been implicated in short stature with dominant transmission...
  96. ncbi Turner's syndrome
    Virginia P Sybert
    Division of Medical Genetics, Department of Medicine, University of Washington School of Medicine, Seattle, USA
    N Engl J Med 351:1227-38. 2004
  97. ncbi A comparison of different definitions of growth response in short prepubertal children treated with growth hormone
    P Bang
    Department of Women s and Children s Health, Karolinska Institute and University Hospital, Stockholm, Sweden
    Horm Res Paediatr 75:335-45. 2011
    ..How to define poor growth response in the management of short growth hormone (GH)-treated children is controversial...
  98. pmc Patterns of postnatal growth in HIV-infected and HIV-exposed children
    Sheila Isanaka
    Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Nutr Rev 67:343-59. 2009
    ..Timely growth monitoring may be used to improve the clinical course and quality of life of these children...
  99. ncbi Prevalence and determinants of stunting and overweight in 3-year-old black South African children residing in the Central Region of Limpopo Province, South Africa
    Ramoteme L Mamabolo
    Medical Sciences Programme, University of Limpopo, Sovenga, South Africa
    Public Health Nutr 8:501-8. 2005
    ..To determine the prevalence of stunting, wasting and overweight and their determinants in 3-year-old children in the Central Region of Limpopo Province, South Africa...
  100. ncbi Child development: risk factors for adverse outcomes in developing countries
    Susan P Walker
    Epidemiology Research Unit, The University of the West Indies, Mona, Jamaica
    Lancet 369:145-57. 2007
    ..Furthermore, risks often occur together or cumulatively, with concomitant increased adverse effects on the development of the world's poorest children...
  101. ncbi Hand-washing, subclinical infections, and growth: a longitudinal evaluation of an intervention in Nepali slums
    Rebecca Langford
    School of Social and Community Medicine, University of Bristol, Canynge Hall, Bristol, BS8 2PS, UK
    Am J Hum Biol 23:621-9. 2011
    ..This is the first study to evaluate the impact of hand-washing on markers of subclinical, asymptomatic infections associated with childhood growth faltering...

Research Grants63

  1. GENETIC CONTROL OF PROTEOGLYCAN METABOLISM
    Jeffrey D Esko; Fiscal Year: 2010
    ..with altered heparan sulfate synthesis, such as neoplastic transformation, atherosclerosis, and various growth disorders associated with connective tissues...
  2. Role of Myc in the Growth Regulation Pathways
    PAOLA BELLOSTA BELLOSTA; Fiscal Year: 2010
    ..conditions in the production of insulin and Growth Factors may cause metabolic disorders, such as diabetes, growth disorders or cancer...
  3. Transgenic Approaches to Evaluate IGF-I Role in Peak BMD
    Subburaman Mohan; Fiscal Year: 2013
    ..growth period may have future ramifications concerning strategies to increase peak bone mass in children with growth disorders. Our studies during the past grant period have provided for the first time irrevocable evidence that the ..
  4. The role of central IGF- 1 feedback in the regulation of growth and metabolism
    CHRISTOPHER JOSEPH ROMERO; Fiscal Year: 2013
    ..Dr. Radovick's long-standing research interests in human growth disorders associated with abnormal pituitary development and her mentoring experience will provide Dr...
  5. REGULATION OF SCLERAL GROWTH AND REMODELING IN MYOPIA
    Jody A Summers; Fiscal Year: 2013
    ..goal is to identify intraocular regulators of scleral growth for the treatment and prevention of ocular growth disorders. Studies using several animal models demonstrate changes in choroidal synthesis of all-trans-retinoic acid (..
  6. Genetics of Juvenile Idiopathic Arthritis and Subtypes
    Susan D Thompson; Fiscal Year: 2010
    ..It is a debilitating disorder in which progressive joint damage and resulting growth disorders may occur. It is the most common chronic childhood rheumatic disease in the Western world...
  7. Mechanisms of Pituitary Tumorigenesis
    Shlomo Melmed; Fiscal Year: 2012
    ..These adenomas account for clinical infertility, growth disorders and hypercortisolism or metabolic dysfunctions associated with hypo-pituitarism...
  8. Sirt1-PPARgamma signaling in placental development and fetal growth disorders
    Mana M Parast; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Fetal growth disorders (both growth restriction and overgrowth) are common pregnancy complications, which carry an increased risk of adverse outcomes in the perinatal period and an increased risk of ..
  9. Coordinated Regulation of Hair Growth and Pigmentation by Dermal Papilla Cells
    Yuhang Zhang; Fiscal Year: 2013
    ..novel strategies for regenerating hair follicles in cases of severe skin wounds and for the treatment of hair growth disorders. Ultimately, the knowledge obtained from our research will also contribute to a broader and deeper ..
  10. WNT SIGNALS IN SKIN AND HAIR DEVELOPMENT AND HAIR GROWTH
    Sarah E Millar; Fiscal Year: 2013
    ..for skin and hair follicle regeneration in cases of congenital absence or loss, and for the treatment of hair growth disorders and epidermal tumors...
  11. Updating Skeletal Maturity Methods for US Children
    Dana L Duren; Fiscal Year: 2010
    ..Skeletal age is an important clinical tool in the management of children with growth disorders, genetic syndromes and those receiving hormonal, orthopedic or orthodontic treatments...
  12. RTK DOMAINS AND RTK DIMERIZATION THERMODYNAMICS
    Kalina Hristova; Fiscal Year: 2013
    ..and thus aid in the development of highly specific therapeutics which can be used to treat cancers and growth disorders. PUBLIC HEALTH RELEVANCE: RTK domains and RTK dimerization thermodynamics Narrative Many pathologies are ..
  13. ALTERATIONS IN BODY COMPOSITION AND GROWTH AT PUBERTY
    Alan Rogol; Fiscal Year: 1999
    ..Both the boys and girls with clinical growth disorders and the controls will be entered as staggered, mixed longitudinal groups...
  14. Cell Competition: Genes That Drive Tissue Replacement
    Nicholas E Baker; Fiscal Year: 2010
    ..be manipulated in order to promote tissue repopulation and regeneration without promoting cancer or other growth disorders. Public Health Relevance: When introducing stem or progenitor cells to repair damaged tissues, maximizing the ..
  15. Rare Genetic Variants as Novel Causes of Idiopathic or Syndromic Short Stature
    ANDREW NAHUM DAUBER; Fiscal Year: 2013
    ..research methods to clinically relevant problems in the field of pediatric endocrinology and specifically growth disorders. During the time period of his K23 grant, Dr...
  16. TUMOR SUPPRESSOR GENES IN HUMAN THYROID NEOPLASMS
    James Fagin; Fiscal Year: 1990
    ..difficulties stem from major gaps in our understanding of the biology and cellular pathophysiology of thyroid growth disorders. There is now growing evidence that tumor progression and neoplastic phenotype is determined by sequential ..
  17. QI-FRET: a new tool in Receptor Tyrosine Kinase research
    Kalina Hristova; Fiscal Year: 2013
    ..gained will ultimately aid the search and refinement of effective RTK-targeted treatments for cancers and growth disorders. PUBLIC HEALTH RELEVANCE: We propose to (i) develop a quantitative imaging FRET (QI-FRET) method that yields ..
  18. Molecular Pathophysiology of Human Growth Disorders
    MICHAEL WAJNRAJCH; Fiscal Year: 2002
    ..We have undertaken a patient-based study of the role of molecular defects in families and individuals with growth disorders that are likely to be due to genetic aberrations in constituents of the Growth Hormone axis...
  19. Physiologic Role of the Somatotroph IGF-1 Receptor
    Christopher Romero; Fiscal Year: 2009
    ..Relevance to public health: Despite medical advances in the treatment of growth disorders with GH and IGF-1, a clear understanding of their relative contributions to somatic growth and the mechanisms ..
  20. PITUITARY TUMOR CELL CULTURES
    Shlomo Melmed; Fiscal Year: 1991
    ..Excessive hormone secretion may result in infertility, growth disorders or metabolic dysfunctions...
  21. MOLECULAR PATHOPHYSIOLOGY OF GROWTH DISORDERS
    MICHAEL WAJNRAJCH; Fiscal Year: 2001
    We have undertaken a patient-based study of the role of molecular defects in individuals with growth disorders. We hypothesize that a subset of individuals with familial severe isolated Growth Hormone (GH) deficiency have a mutation in a ..
  22. WNT SIGNALS IN SKIN AND HAIR DEVELOPMENT AND HAIR GROWTH
    Sarah E Millar; Fiscal Year: 2010
    ..for regenerating hair follicles in cases of congenital absence or loss, and for the treatment of hair growth disorders. However, as activating mutations in beta-catenin can cause hair follicle tumors, it will be of critical ..
  23. IMPAIRED SOMATOMEDIN RESPONSIVENESS AND GROWTH FAILURE
    Stephen Rosenthal; Fiscal Year: 1990
    ..at the University of California San Francisco (UCSF), I have developed and pursued a primary interest in growth disorders of childhood, and in particular, factors involved in the regulation of growth hormone (GH) and the GH-..
  24. MECHANISMS OF GROWTH HORMONE HYPERSECRETION IN DIABETES
    Robert Cohen; Fiscal Year: 1990
    ..aid in improving glycemic control and in evaluating GH's role in the development of diabetic retinopathy and growth disorders associated with diabetes in childhood...
  25. GROWTH AND DIFFERENTIATION OF THE PITUITARY GLAND
    DORIS WILSON; Fiscal Year: 1993
    ..development of the human pituitary gland, particularly with respect to pituitary dwarfism and related growth disorders, as well as to the formation of pituitary adenomas and to various dysplasias involving pituitary target ..
  26. Early Diagnosis of Growth Disorders Uing MR Imaging
    Diego Jaramillo; Fiscal Year: 2004
    ....
  27. CELL CULTURE SURFACES FOR BONE RESEARCH
    Mitchell Klausner; Fiscal Year: 1991
    ..these molecular mechanisms gives insight into the origins and treatment of various bone disorders including growth disorders in children and osteoporosis in post menopausal women...
  28. DESCRIPTION AND PREDICTION OF HUMAN GROWTH IN STATURE
    R Bock; Fiscal Year: 2000
    ..of quantitative models and standards to aid pediatricians in monitoring children's growth and diagnosing growth disorders. The project will provide computer-based procedures for predicting a child's course in growth from current ..
  29. IGF AXIS IN ASTHMA
    Pinchas Cohen; Fiscal Year: 2002
    ..We believe that these studies may help us understand the dis-regulated growth of asthmatic airway smooth muscle and allow us to optimize our therapeutic approaches to this disease. ..
  30. IGF-I: A Nutrition-Regulated Target in Prostate Cancer
    Pinchas Cohen; Fiscal Year: 2007
    ....
  31. Genomic and Non-Genomic Effects of IGFBP-3 on Apoptosis
    Pinchas Cohen; Fiscal Year: 2004
    ..If successful our findings may validate novel targets for clinical therapy development for use in men with CaP. ..
  32. The Role of IGF2 in Fetal Growth Restriction
    Pinchas Cohen; Fiscal Year: 2008
    ..abstract_text> ..
  33. MICRONUTRIENTS AND MOTHER TO CHILD TRANSMISSION OF HIV
    Richard Semba; Fiscal Year: 2001
    ..The relationship between mastitis and breastmilk HIV load and the epidemiology and microbiology of mastitis will be examined in a new cohort of HIV-infected lactating women. ..
  34. VITAMIN A SUPPLEMENTATION FOR HIV INFECTED CHILDREN
    Richard Semba; Fiscal Year: 2002
    ....
  35. Hepcidin and the pathogenesis of anemia in older adults.
    Richard D Semba; Fiscal Year: 2010
    ..This study should provide new insight into the epidemiology and biological mechanisms of anemia among older adults and help identify strategies aimed at the prevention and treatment of anemia. ..
  36. Oxidative Stress and the Pathogenesis of Sarcopenia and Disability in Older Women
    Richard Semba; Fiscal Year: 2008
    ..AGEs are a potentially modifiable risk factor, as circulating AGEs can be lowered by dietary modification and by pharmacological intervention. ..
  37. ADJUNCT VITAMIN A THERAPY FOR TUBERCULOSIS AND HIV/AIDS
    Richard Semba; Fiscal Year: 2005
    ....
  38. Iron Deficiency and Anemia in HIV and HCV-Infected Women
    Richard Semba; Fiscal Year: 2005
    ..S. and elsewhere. ..
  39. FUNCTION OF NOGGIN IN HAIR FOLLICLE GROWTH AND DISEASE
    Vladimir Botchkarev; Fiscal Year: 2006
    Despite different pathogenic mechanisms, most common hair growth disorders (androgenic alopecia and alopecia areata) are characterized by the development of hair follicle miniaturization with significant elongation of the resting stage, ..
  40. MOLECULAR MECHANISMS OF CHEMOTHERAPY-INDUCED HAIR LOSS
    Vladimir Botchkarev; Fiscal Year: 2005
    ..Patients with many forms of p53-negative cancers treated by chemotherapy may ultimately benefit from this study. ..
  41. Clinical Performance Measures & Outcomes in Adolescents
    Susan Furth; Fiscal Year: 2005
    ..abstract_text> ..
  42. Assessing Functional Outcomes in Adolescent with ESRD
    Susan Furth; Fiscal Year: 2002
    ..This experience will give Dr. Furth the tools she needs to develop into an independent clinical investigator in a nurturing academic environment. ..
  43. ASSESSING PATIENT OUTCOMES IN PEDIATRIC ESRD
    Susan Furth; Fiscal Year: 2003
    ..Furth the tools she needs to develop into an independent clinical investigator in a nurturing academic environment. ..
  44. A ROLE FOR NOGGIN AND BMP2/4 IN HAIR GROWTH CONTROL
    Vladimir Botchkarev; Fiscal Year: 2003
    ..from active growth to regression during postnatal development, in normal skin and in skin affected by hair growth disorders, are still poorly understood...
  45. Androgen effect on motor/cognitive outcome in Klinefelter syndrome
    Judith L Ross; Fiscal Year: 2010
    ..If successful, androgen replacement in the clinical management of KS would commence early in childhood rather than adolescence or adulthood. ..
  46. ARTHEROSCLEROSIS IN INSULIN-RESISTANT, HYPERLIPIDEMIC P*
    David Clemmons; Fiscal Year: 2005
    ....
  47. GENETICS OF COGNITION IN ADULT TURNER SYNDROME
    Judith Ross; Fiscal Year: 2005
    ..Characterization of specific TS causative genes would provide insight into the pathophysiology of 45,X, Turner syndrome, as well as the process of normal neurocognitive development. ..
  48. Vitamins, Breast Milk HIV Shedding and Child Health
    Eduardo Villamor; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  49. IGFBP5 AND INTEGRINS AND CONTROLLING IGF1 ACTIONS
    David Clemmons; Fiscal Year: 2002
    ....
  50. MECHANISMS BY WHICH IGF-I STIMULATES SMOOTH MUSCLE CELLS
    David Clemmons; Fiscal Year: 2007
    ..The results may suggest novel strategies for interfering with these processes to alter the progression of atherosclerosis. ..
  51. Chaperones, ROS systems, & IGF-1:Roles in vascular aging
    David Clemmons; Fiscal Year: 2008
    ..abstract_text> ..
  52. The World Congress on Chromosome Abnormalities
    Jannine Cody; Fiscal Year: 2004
    ..This application seeks funding for the Scientific Sessions of the World Congress on Chromosome Abnormalities, to be held in June of 2004 in San Antonio, Texas. ..
  53. ANDROGEN EFFECTS ON COGNITION IN TURNER SYNDROME
    Judith Ross; Fiscal Year: 2007
    ..In addition, these data will help determine how to optimize cognitive function in Turner syndrome and will extend knowledge of the mechanisms of male/female cognitive dimorphisms. ..
  54. Identification of Dosage Sensitive Genes on 18q
    Jannine Cody; Fiscal Year: 2007
    ..Furthermore, it will begin to piece together the genotypic components that combine to generate the full phenotype of a child with an 18q deletion. ..
  55. Development of a Novel Method for Inhibiting Atherosclerosis in Diabetes
    David Clemmons; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  56. BUILDING BETTER BONES IN CHILDREN
    Babette Zemel; Fiscal Year: 2003
    ..abstract_text> ..
  57. Biochemical correlates/cognition/Barth syndrome
    MICHELE MAZZOCCO; Fiscal Year: 2004
    ..Methods will involve cognitive assessment of children with Barth syndrome and matched peers, paired comparisons, and correlation analyses. ..
  58. Course of psychopathology in female youth: Analysis with extant longitudinal data
    Joseph Biederman; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..