granuloma

Summary

Summary: A relatively small nodular inflammatory lesion containing grouped mononuclear phagocytes, caused by infectious and noninfectious agents.

Top Publications

  1. ncbi Characterization of the tuberculous granuloma in murine and human lungs: cellular composition and relative tissue oxygen tension
    Ming C Tsai
    Department of Medicinem Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY, USA
    Cell Microbiol 8:218-32. 2006
  2. pmc Neutrophils exert protection in the early tuberculous granuloma by oxidative killing of mycobacteria phagocytosed from infected macrophages
    Chao Tsung Yang
    Department of Microbiology, University of Washington, Seattle, WA 98195, USA
    Cell Host Microbe 12:301-12. 2012
  3. ncbi Revisiting the role of the granuloma in tuberculosis
    Lalita Ramakrishnan
    Department of Microbiology, University of Washington, Seattle, Washington 98195, USA
    Nat Rev Immunol 12:352-66. 2012
  4. pmc The role of the granuloma in expansion and dissemination of early tuberculous infection
    J Muse Davis
    Immunology and Molecular Pathogenesis Graduate Program, Emory University, Atlanta, GA 30322, USA
    Cell 136:37-49. 2009
  5. pmc Foamy macrophages from tuberculous patients' granulomas constitute a nutrient-rich reservoir for M. tuberculosis persistence
    Pascale Peyron
    CNRS, IPBS Institut de Pharmacologie et de Biologie Structurale, Département Mécanismes Moléculaires des Infections Mycobactériennes, Toulouse, France
    PLoS Pathog 4:e1000204. 2008
  6. ncbi An in vitro model of the leukocyte interactions associated with granuloma formation in Mycobacterium tuberculosis infection
    Kristin A Birkness
    Mycobacteriology Laboratory Branch, Division of Tuberculosis Elimination, Centers for Disease Control and Prevention, Atlanta, GA, USA
    Immunol Cell Biol 85:160-8. 2007
  7. ncbi Real-time visualization of mycobacterium-macrophage interactions leading to initiation of granuloma formation in zebrafish embryos
    J Muse Davis
    Department of Microbiology, University of Washington School of Medicine, Seattle, WA 98195, USA
    Immunity 17:693-702. 2002
  8. pmc Tuberculous granuloma induction via interaction of a bacterial secreted protein with host epithelium
    Hannah E Volkman
    Molecular and Cellular Biology Graduate Program, University of Washington, Seattle, WA 98155, USA
    Science 327:466-9. 2010
  9. pmc Tumor necrosis factor signaling mediates resistance to mycobacteria by inhibiting bacterial growth and macrophage death
    Hilary Clay
    Molecular and Cellular Biology Graduate Program, University of Washington, Seattle, WA 98195, USA
    Immunity 29:283-94. 2008
  10. pmc Expansion and function of Foxp3-expressing T regulatory cells during tuberculosis
    James P Scott-Browne
    Department of Pediatrics, University of Washington, Seattle, WA 98195, USA
    J Exp Med 204:2159-69. 2007

Research Grants

Detail Information

Publications290 found, 100 shown here

  1. ncbi Characterization of the tuberculous granuloma in murine and human lungs: cellular composition and relative tissue oxygen tension
    Ming C Tsai
    Department of Medicinem Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY, USA
    Cell Microbiol 8:218-32. 2006
    ..tuberculosis...
  2. pmc Neutrophils exert protection in the early tuberculous granuloma by oxidative killing of mycobacteria phagocytosed from infected macrophages
    Chao Tsung Yang
    Department of Microbiology, University of Washington, Seattle, WA 98195, USA
    Cell Host Microbe 12:301-12. 2012
    ..Neutrophils are subsequently recruited to the nascent granuloma in response to signals from dying infected macrophages within the granuloma, which they phagocytose...
  3. ncbi Revisiting the role of the granuloma in tuberculosis
    Lalita Ramakrishnan
    Department of Microbiology, University of Washington, Seattle, Washington 98195, USA
    Nat Rev Immunol 12:352-66. 2012
    The granuloma, which is a compact aggregate of immune cells, is the hallmark structure of tuberculosis. It is historically regarded as a host-protective structure that 'walls off' the infecting mycobacteria...
  4. pmc The role of the granuloma in expansion and dissemination of early tuberculous infection
    J Muse Davis
    Immunology and Molecular Pathogenesis Graduate Program, Emory University, Atlanta, GA 30322, USA
    Cell 136:37-49. 2009
    ..Here we use quantitative intravital microscopy to reveal distinct steps of granuloma formation and assess their consequence for infection...
  5. pmc Foamy macrophages from tuberculous patients' granulomas constitute a nutrient-rich reservoir for M. tuberculosis persistence
    Pascale Peyron
    CNRS, IPBS Institut de Pharmacologie et de Biologie Structurale, Département Mécanismes Moléculaires des Infections Mycobactériennes, Toulouse, France
    PLoS Pathog 4:e1000204. 2008
    ..In-depth investigation of M. tuberculosis interactions with granuloma-specific cell populations are needed to gain insight into mycobacterial persistence, and to better understand ..
  6. ncbi An in vitro model of the leukocyte interactions associated with granuloma formation in Mycobacterium tuberculosis infection
    Kristin A Birkness
    Mycobacteriology Laboratory Branch, Division of Tuberculosis Elimination, Centers for Disease Control and Prevention, Atlanta, GA, USA
    Immunol Cell Biol 85:160-8. 2007
    ..This granuloma can sequester and contain the bacteria preventing active disease, and if the granuloma is maintained, these ..
  7. ncbi Real-time visualization of mycobacterium-macrophage interactions leading to initiation of granuloma formation in zebrafish embryos
    J Muse Davis
    Department of Microbiology, University of Washington School of Medicine, Seattle, WA 98195, USA
    Immunity 17:693-702. 2002
    ..of macrophage aggregates with pathological hallmarks of granulomas and activation of previously identified granuloma-specific Mycobacterium genes...
  8. pmc Tuberculous granuloma induction via interaction of a bacterial secreted protein with host epithelium
    Hannah E Volkman
    Molecular and Cellular Biology Graduate Program, University of Washington, Seattle, WA 98155, USA
    Science 327:466-9. 2010
    ..However, analysis of Mycobacterium marinum in zebrafish has shown that the early granuloma facilitates mycobacterial growth; uninfected macrophages are recruited to the granuloma where they are ..
  9. pmc Tumor necrosis factor signaling mediates resistance to mycobacteria by inhibiting bacterial growth and macrophage death
    Hilary Clay
    Molecular and Cellular Biology Graduate Program, University of Washington, Seattle, WA 98195, USA
    Immunity 29:283-94. 2008
    ..In the absence of TNF, intracellular bacterial growth and granuloma formation were accelerated and was followed by necrotic death of overladen macrophages and granuloma breakdown...
  10. pmc Expansion and function of Foxp3-expressing T regulatory cells during tuberculosis
    James P Scott-Browne
    Department of Pediatrics, University of Washington, Seattle, WA 98195, USA
    J Exp Med 204:2159-69. 2007
    ..Thus, after aerosol infection, T reg cells proliferate and accumulate at sites of infection, and have the capacity to suppress immune responses that contribute to the control of Mtb...
  11. pmc Tumor necrosis factor neutralization results in disseminated disease in acute and latent Mycobacterium tuberculosis infection with normal granuloma structure in a cynomolgus macaque model
    Philana Ling Lin
    Children s Hospital of Pittsburgh of the University of Pittsburgh Medical Center, Pittsburgh, PA, USA
    Arthritis Rheum 62:340-50. 2010
    ..impaired signaling by TNF causes exacerbation of both acute and chronic infection associated with aberrant granuloma formation and maintenance...
  12. pmc FoxP3+ regulatory T cells suppress early stages of granuloma formation but have little impact on sarcoidosis lesions
    Cécile Taflin
    INSERM UMR S 945, Paris, France
    Am J Pathol 174:497-508. 2009
    ..46, P = 0.03, n = 20). Furthermore, Treg depletion accelerates in vitro granuloma growth in mononuclear cell cultures of healthy controls, but not in those from patients with active sarcoidosis...
  13. pmc Tuberculous granulomas are hypoxic in guinea pigs, rabbits, and nonhuman primates
    Laura E Via
    Tuberculosis Research Section, Laboratory of Clinical Infectious Disease, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, MD 20852, USA
    Infect Immun 76:2333-40. 2008
    ..Thus, three independent lines of evidence support the hypothesis that hypoxic microenvironments are an important feature of some lesions in these animal models of tuberculosis...
  14. ncbi Penitentiary or penthouse condo: the tuberculous granuloma from the microbe's point of view
    Carleitta Paige
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Cell Microbiol 12:301-9. 2010
    b>Granuloma formation represents a pivotal point during human infection with Mycobacterium tuberculosis, for this structure may limit mycobacterial spread and prevent active disease, while at the same time allow for the survival and ..
  15. pmc CD4+ T cell-mediated granulomatous pathology in schistosomiasis is downregulated by a B cell-dependent mechanism requiring Fc receptor signaling
    D Jankovic
    Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Exp Med 187:619-29. 1998
    ..The role of B cells in the regulation of CD4-dependent host responses is less well understood. Hepatic egg granuloma formation and fibrosis in murine schistosomiasis are dependent on CD4+ lymphocytes, and previous studies have ..
  16. pmc Zebrafish embryo screen for mycobacterial genes involved in the initiation of granuloma formation reveals a newly identified ESX-1 component
    Esther J M Stoop
    Department of Medical Microbiology and Infection Control, VU University Medical Center, Van der Boechorststraat 7, 1081 BT Amsterdam, The Netherlands
    Dis Model Mech 4:526-36. 2011
    ..In this study, we aimed to identify new mycobacterial factors involved in the initial stages of granuloma formation...
  17. ncbi Tumor necrosis factor-alpha is required in the protective immune response against Mycobacterium tuberculosis in mice
    J L Flynn
    Department of Molecular Genetics and Biochemistry, University of Pittsburgh School of Medicine, Pennsylvania 15261, USA
    Immunity 2:561-72. 1995
    ..TNF alpha and the 55 kDa TNF receptor are necessary conditions for protection against murine M. tuberculosis infection, but are not solely responsible for the tissue damage observed...
  18. ncbi TNF regulates chemokine induction essential for cell recruitment, granuloma formation, and clearance of mycobacterial infection
    Daniel R Roach
    Centenary Institute of Cancer Medicine and Cell Biology, Newton, Sydney, New South Wales, Australia
    J Immunol 168:4620-7. 2002
    ..Therefore, TNF orchestrates early induction of chemokines and initial leukocyte recruitment, but has an additional role in the aggregation of leukocytes into functional granulomas capable of controlling virulent mycobacterial infection...
  19. pmc Pulmonary mycobacterial granuloma increased IL-10 production contributes to establishing a symbiotic host-microbe microenvironment
    Christopher R Shaler
    Department of Pathology and Molecular Medicine, Centre for Gene Therapeutics, and M G DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, Ontario, Canada
    Am J Pathol 178:1622-34. 2011
    The granuloma, a hallmark of host defense against pulmonary mycobacterial infection, has long been believed to be an active type 1 immune environment...
  20. ncbi Identifying control mechanisms of granuloma formation during M. tuberculosis infection using an agent-based model
    Jose L Segovia-Juarez
    Department of Microbiology and Immunology, University of Michigan, Ann Arbor, MI 48109, USA
    J Theor Biol 231:357-76. 2004
    ..Thus, understanding granuloma formation and function is essential for improving both diagnosis and treatment of tuberculosis...
  21. ncbi An in vitro dual model of mycobacterial granulomas to investigate the molecular interactions between mycobacteria and human host cells
    Marie Pierre Puissegur
    Department of Molecular Mechanisms of Mycobacterial Infections, Institut de Pharmacologie et de Biologie Structurale, CNRS UMR5089, 205, route de Narbonne, 31077 Toulouse, France
    Cell Microbiol 6:423-33. 2004
    ..Besides morphological similarities, in vitro granulomas also functionally resemble natural ones, with the development of intense cellular co-operation and intracellular mycobactericidal activities...
  22. ncbi Essential role of IL-17A in the formation of a mycobacterial infection-induced granuloma in the lung
    Yuko Okamoto Yoshida
    Tropical Biosphere Research Center, Division of Host Defense and Vaccinology, Department of Microbiology, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan
    J Immunol 184:4414-22. 2010
    ..IL-17A is involved in mature granuloma formation in the mycobacteria-infected lung...
  23. ncbi Impairment of mycobacterial immunity in human interleukin-12 receptor deficiency
    F Altare
    INSERM U429, Hopital Necker Enfants Malades, Paris 75015, France
    Science 280:1432-5. 1998
    ..Thus, IL-12-dependent IFN-gamma secretion in humans seems essential in the control of mycobacterial infections, despite the formation of mature granulomas due to IL-12-independent IFN-gamma secretion...
  24. pmc Immunopathology of schistosomiasis
    Mark S Wilson
    Laboratory of Parasitic Diseases, Immunopathogenesis Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Immunol Cell Biol 85:148-54. 2007
    ....
  25. pmc Tuberculous granuloma formation is enhanced by a mycobacterium virulence determinant
    Hannah E Volkman
    Molecular and Cellular Biology Graduate Program, University of Washington, Seattle, Washington, USA
    PLoS Biol 2:e367. 2004
    ..The tuberculous granuloma is essential for host containment of mycobacterial infection, although it does not always eradicate it...
  26. pmc Granuloma formation and host defense in chronic Mycobacterium tuberculosis infection requires PYCARD/ASC but not NLRP3 or caspase-1
    Erin McElvania TeKippe
    Department of Microbiology and Immunology, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America
    PLoS ONE 5:e12320. 2010
    ..Decreased survival of Pycard(-/-) animals was associated with defective granuloma formation...
  27. pmc Caseation of human tuberculosis granulomas correlates with elevated host lipid metabolism
    Mi Jeong Kim
    Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY, USA
    EMBO Mol Med 2:258-74. 2010
    ..progression of human tuberculosis (TB) to active disease and transmission involves the development of a caseous granuloma that cavitates and releases infectious Mycobacterium tuberculosis bacilli...
  28. ncbi B cell-deficient mice are highly resistant to Leishmania donovani infection, but develop neutrophil-mediated tissue pathology
    S C Smelt
    Department of Infectious Diseases, London School of Hygiene and Tropical Medicine, London United Kingdom
    J Immunol 164:3681-8. 2000
    ..The rapid clearance of parasites in muMT mice was associated with accelerated and more extensive hepatic granuloma formation compared with wild-type mice...
  29. pmc Tissue granuloma structure-function in experimental visceral leishmaniasis
    H W Murray
    Department of Medicine, Weill College of Cornell University, New York 10021, USA
    Int J Exp Pathol 82:249-67. 2001
    ..This pro-host defense granuloma structure-function relationship, in which histologically mature granulomas provide the microenvironment for ..
  30. pmc Identification of key processes that control tumor necrosis factor availability in a tuberculosis granuloma
    Mohammad Fallahi-Sichani
    Department of Chemical Engineering, University of Michigan, Ann Arbor, MI, USA
    PLoS Comput Biol 6:e1000778. 2010
    ..To characterize mechanisms that control TNF availability within a TB granuloma, we developed a multi-scale two compartment partial differential equation model that describes a granuloma as a ..
  31. ncbi IL-10 mediates susceptibility to Leishmania donovani infection
    M L Murphy
    Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia 19104, USA
    Eur J Immunol 31:2848-56. 2001
    ..Together these studies demonstrate for the first time that IL-10 is a critical component of the immune response that inhibits resistance to L. donovani...
  32. pmc AIM inhibits apoptosis of T cells and NKT cells in Corynebacterium-induced granuloma formation in mice
    Kazuhisa Kuwata
    Department of Cellular Function, Division of Cellular and Molecular Pathology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    Am J Pathol 162:837-47. 2003
    ..parvum-stimulated livers in vitro. These results indicate that AIM functions to induce resistance to apoptosis within NKT cells and T cells, and supports the host defense in granulomatous inflammation...
  33. pmc Evaluation of a mouse model of necrotic granuloma formation using C3HeB/FeJ mice for testing of drugs against Mycobacterium tuberculosis
    Emily R Driver
    Mycobacterial Research Laboratories, Department of Microbiology, Colorado State University, Fort Collins, Colorado, USA
    Antimicrob Agents Chemother 56:3181-95. 2012
    ..These results suggest that the Kramnik mouse model will be a valuable model to test antituberculosis drugs, especially against bacilli that persist within necrotic lesions...
  34. pmc Both interleukin-4 (IL-4) and IL-4 receptor alpha signaling contribute to the development of hepatic granulomas with optimal antileishmanial activity
    Simona Stager
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom
    Infect Immun 71:4804-7. 2003
    ..the increased parasite load observed in IL-4(-/-) and IL-4 receptor alpha(-/-) mice correlates with retarded granuloma maturation and antileishmanial activity and that the increased parasite load observed in IL-4 receptor alpha(-/-)..
  35. pmc Granuloma encapsulation is a key factor for containing tuberculosis infection in minipigs
    Olga Gil
    Unitat de Tuberculosi Experimental UTE, Institut per a la Investigació en Ciències de la Salut Germans Trias i Pujol, Universitat Autonoma de Barcelona, Badalona, Catalonia, Spain
    PLoS ONE 5:e10030. 2010
    ..By providing a local pulmonary structure similar to that in humans, the mini-pig model highlights new aspects that could be key to a better understanding tuberculosis infection control in humans...
  36. ncbi New insights into the function of granulomas in human tuberculosis
    Timo Ulrichs
    Department of Immunology, Max Planck Institute for Infection Biology, Berlin, Germany
    J Pathol 208:261-9. 2006
    The human tuberculous granuloma provides the morphological framework for local immune processes central to the outcome of tuberculosis...
  37. pmc Synergy between individual TNF-dependent functions determines granuloma performance for controlling Mycobacterium tuberculosis infection
    J Christian J Ray
    Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    J Immunol 182:3706-17. 2009
    ..One central regulator of host responses to infection, including granuloma formation, is the pleiotropic cytokine TNF-alpha...
  38. ncbi Chemokines and tuberculosis
    Holly M Scott Algood
    Department of Molecular Genetics and Biochemistry and Molecular Virology and Microbiology Graduate Program, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    Cytokine Growth Factor Rev 14:467-77. 2003
    ..A primary pathologic feature of M. tuberculosis infection is the formation of a granuloma. Immune cells migrate to the lung and then through the lung to the site of infection to form a granuloma...
  39. pmc Inflammatory dendritic cells migrate in and out of transplanted chronic mycobacterial granulomas in mice
    Heidi A Schreiber
    Department of Pathology and Laboratory Medicine, School of Medicine and Public Health, University of Wisconsin, Madison, Wisconsin, USA
    J Clin Invest 121:3902-13. 2011
    ..Compared with tissue-resident DC populations, CD11c+ cells migrating out of granuloma-containing tissue had an unexpected systemic dissemination pattern...
  40. ncbi Identification and real-time imaging of a myc-expressing neutrophil population involved in inflammation and mycobacterial granuloma formation in zebrafish
    Annemarie H Meijer
    Institute of Biology, Leiden University, Wassenaarseweg 64, 2333 AL Leiden, The Netherlands
    Dev Comp Immunol 32:36-49. 2008
    ..Using real-time confocal imaging we demonstrate that these cells migrate to sites of inflammation and are involved in innate immune responses towards infections, including Mycobacterium marinum-induced granuloma formation.
  41. pmc Retnla (relmalpha/fizz1) suppresses helminth-induced Th2-type immunity
    John T Pesce
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
    PLoS Pathog 5:e1000393. 2009
    ..Pulmonary granuloma formation induced by the eggs of the helminth parasite Schistosoma mansoni is dependent on IL-4 and IL-13 and ..
  42. ncbi Generation and characterization of multicellular heterospheroids formed by human peripheral blood mononuclear cells
    Ulrike Seitzer
    Division of Veterinary Infectiology and Immunology, Research Center Borstel, Borstel, Germany
    Cells Tissues Organs 174:110-6. 2003
    ..These characteristics have not been described for in vitro models of granuloma formation before and thus this new culture technique may prove to be a useful tool for analyzing aspects ..
  43. pmc First molecular identification of the zoonotic parasite Anisakis pegreffii (Nematoda: Anisakidae) in a paraffin-embedded granuloma taken from a case of human intestinal anisakiasis in Italy
    Simonetta Mattiucci
    Department of Public Health and Infectious Diseases, Sapienza University of Rome, Ple Aldo Moro 5, 00185 Rome, Italy
    BMC Infect Dis 11:82. 2011
    ..Thus, molecular-based diagnostic approaches are warranted...
  44. pmc Retroviral Foxp3 gene transfer ameliorates liver granuloma pathology in Schistosoma mansoni infected mice
    Kameshwar P Singh
    Department of Immunology and Microbiology, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Immunology 114:410-7. 2005
    ..The percentage of granuloma CD4(+) CD25(+) T cells rose from 12% at 8 weeks to 88% at 16 weeks of the infection. Foxp3 expression was 3...
  45. pmc Multiscale computational modeling reveals a critical role for TNF-α receptor 1 dynamics in tuberculosis granuloma formation
    Mohammad Fallahi-Sichani
    Department of Chemical Engineering, University of Michigan, Ann Arbor, MI 48109, USA
    J Immunol 186:3472-83. 2011
    ..Availability of TNF-α within a granuloma has been proposed to play a critical role in immunity to M. tuberculosis...
  46. ncbi The expression of TLR9 in human cutaneous leishmaniasis is associated with granuloma
    F F Tuon
    Department of Infectious Diseases, University of Sao Paulo, Medical School, Sao Paulo, Brasil
    Parasite Immunol 32:769-72. 2010
    ..TLR9 expression was primarily observed in the granuloma. The protein was detected in a few cells in the dermis...
  47. ncbi An in vitro model for the lepromatous leprosy granuloma: fate of Mycobacterium leprae from target macrophages after interaction with normal and activated effector macrophages
    Deanna A Hagge
    National Hansen s Disease Programs, Laboratory Research Branch, Louisiana State University School of Veterinary Medicine, Skip Bertman Drive, Baton Rouge, LA 70803, USA
    J Immunol 172:7771-9. 2004
    The lepromatous leprosy granuloma is a dynamic entity requiring a steady influx of macrophages (Mphi) for its maintenance...
  48. pmc Heme oxygenase-1 promotes granuloma development and protects against dissemination of mycobacteria
    Doron Regev
    Division of Pulmonary, Critical Care and Sleep Medicine, College of Medicine, University of Florida, Gainesville, FL, USA
    Lab Invest 92:1541-52. 2012
    ..The hallmark of pulmonary mycobacterial infections is the formation of granuloma in the lung...
  49. pmc Mononuclear cell recruitment, granuloma assembly, and response to treatment in experimental visceral leishmaniasis: intracellular adhesion molecule 1-dependent and -independent regulation
    H W Murray
    Department of Medicine, Weill Medical College of Cornell University, New York, New York 10021, USA
    Infect Immun 68:6294-9. 2000
    ..mice proceeded to express a compensatory, ICAM-1-independent response leading to mononuclear cell influx and granuloma assembly, control over visceral infection, and the capacity to respond to Sb...
  50. pmc Short report: A calcified Taenia solium granuloma associated with recurrent perilesional edema causing refractory seizures: histopathological features
    Winnie W Ooi
    Department of Infectious Diseases, Lahey Clinic, Burlington, Massachusetts, USA
    Am J Trop Med Hyg 85:460-3. 2011
    We describe the first detailed histological description of an excised calcified Taenia solium granuloma from a patient who developed recurrent seizures associated with perilesional edema surrounding a calcified cysticercus (PEC)...
  51. pmc Mice that lack the interferon-gamma receptor have profoundly altered responses to infection with Bacillus Calmette-Guérin and subsequent challenge with lipopolysaccharide
    R Kamijo
    Department of Microbiology, Kaplan Cancer Center, New York University Medical Center, New York 10016
    J Exp Med 178:1435-40. 1993
    ....
  52. pmc Multi-scale modeling predicts a balance of tumor necrosis factor-α and interleukin-10 controls the granuloma environment during Mycobacterium tuberculosis infection
    Nicholas A Cilfone
    Department of Chemical Engineering, University of Michigan, Ann Arbor, Michigan, USA
    PLoS ONE 8:e68680. 2013
    ..that IL-10 is necessary to modulate macrophage activation levels and to prevent host-induced tissue damage in a granuloma, an aggregate of cells that forms in response to Mtb...
  53. ncbi Suture granuloma showing false-positive finding on PET/CT after head and neck cancer surgery
    Masahiro Kikuchi
    Department of Otolaryngology, Kobe City Medical Center General Hospital, 4 6 Minatojima Nakamachi, Chuo Ku, Kobe 650 0046, Japan
    Auris Nasus Larynx 39:94-7. 2012
    We report herein two cases of suture granuloma showing focal intense 2-deoxy-2-[(18)F]fluoro-d-glucose (FDG)-uptake in positron emission tomography (PET)...
  54. pmc Human granuloma in vitro model, for TB dormancy and resuscitation
    Nidhi Kapoor
    Burnett School of Biomedical Sciences, College of Medicine, University of Central Florida, Orlando, Florida, United States of America
    PLoS ONE 8:e53657. 2013
    ..Upon infection, Mycobacterium tuberculosis (Mtb) causes formation of granuloma where the pathogen goes into dormant state and can live for decades before resuscitation to develop active ..
  55. pmc Latent tuberculosis: what the host "sees"?
    Hannah P Gideon
    Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, W1144 Biomedical Science Tower, Pittsburgh, PA 15261, USA
    Immunol Res 50:202-12. 2011
    ..This review aims to summarize the recent findings in human and non-human primate models of tuberculosis that have led to new concepts of latent tuberculosis...
  56. pmc Protective immune mechanisms in helminth infection
    Robert M Anthony
    The Laboratory of Molecular Genetics and Immunology, The Rockefeller University, 1230 York Avenue, New York, New York 10021, USA
    Nat Rev Immunol 7:975-87. 2007
    ..In this Review, we examine recent findings regarding the mechanisms of protection in helminth infections that have been elucidated in murine models and discuss the implications of these findings in terms of future therapies...
  57. pmc Efficacy of Mycobacterium indicus pranii immunotherapy as an adjunct to chemotherapy for tuberculosis and underlying immune responses in the lung
    Ankan Gupta
    Product Development Cell, National Institute of Immunology, New Delhi, Delhi, India
    PLoS ONE 7:e39215. 2012
    ..Immunotherapy could be beneficial for the effective management of the disease. Previously we showed the protective efficacy of Mycobacterium indicus pranii (MIP) when given as prophylactic vaccine in animal models of tuberculosis...
  58. ncbi T cell contributions to the different phases of granuloma formation
    Dominic O Co
    Department of Pathology, University of Wisconsin Madison, Madison, WI 53706, USA
    Immunol Lett 92:135-42. 2004
    ..An in depth knowledge of granuloma formation is essential to our understanding of protection against chronic infection as well as the dysregulation ..
  59. ncbi Experimental models of Schistosoma mansoni infection
    Allen W Cheever
    Biomedical Research Institute, MD 20852 1709, USA
    Mem Inst Oswaldo Cruz 97:917-40. 2002
    ....
  60. ncbi Evolution of granulomas in lungs of mice infected aerogenically with Mycobacterium tuberculosis
    P J Cardona
    Unitat de Tuberculosi Experimental, Servei de Microbiologia, Hospital Universitari Germans Trias i Pujol, Universitat Autonoma de Barcelona, Barcelona, Catalonia, Spain
    Scand J Immunol 52:156-63. 2000
    ..The latter would be in agreement with the persistence of chronic pulmonary infection in spite of a concomitant strong T helper 1 cell response...
  61. pmc Endogenous IL-13 plays a crucial role in liver granuloma maturation during Leishmania donovani infection, independent of IL-4Rα-responsive macrophages and neutrophils
    Emma McFarlane
    Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, UK
    J Infect Dis 204:36-43. 2011
    ..This correlated with significantly retarded granuloma maturation in IL-13(-/-) mice, defective interferon γ (IFN-γ) production, and elevated IL-4 and interleukin 10 ..
  62. ncbi Floating between the poles of pathology and protection: can we pin down the granuloma in tuberculosis?
    Stephen T Reece
    Max Planck Institute for Infection Biology, Department of Immunology, Chariteplatz 1, 10117 Berlin, Germany
    Curr Opin Microbiol 15:63-70. 2012
    The granuloma in tuberculosis (TB), referred to as the tubercle, is a lesion containing multiple cell types and is the one definite hallmark of this disease...
  63. ncbi Pulmonary granulomas caused experimentally in mice by a recombinant trigger-factor protein of Propionibacterium acnes
    Junko Minami
    Department of Human Pathology, Tokyo Medical and Dental University, Japan
    J Med Dent Sci 50:265-74. 2003
    ..acnes caused pulmonary granulomas in primed and unprimed mice sensitized with the protein and adjuvant. Sarcoid granulomas may form during hypersensitivity to antigens of P. acnes indigenous to the affected organ...
  64. pmc Evidence for mycobacteria in sarcoidosis
    Isaac Brownell
    Dermatology Branch, CCR, NCI, NIH, Bethesda, Maryland, USA
    Am J Respir Cell Mol Biol 45:899-905. 2011
    ..This information, coupled with a better understanding of genetic susceptibility to this complex disease, has therapeutic implications...
  65. ncbi Identification of Mycobacterium marinum 65 kD heat shock protein gene by polymerase chain reaction restriction analysis from lesions of swimming pool granuloma
    Lin Cai
    Department of Dermatology, Peking University People s Hospital, Beijing 100044, China
    Chin Med J (Engl) 119:43-8. 2006
    ..marinum) are mostly seen to cause skin infection. It is therefore important to establish a rapid approach for detection and identification of M. marinum from lesions of patients with suspected M. marinum infections...
  66. ncbi The pathology of pulmonary sarcoidosis: update
    Yanling Ma
    Department of Pathology, Keck School of Medicine of the University of Southern California, Los Angeles, California, USA
    Semin Diagn Pathol 24:150-61. 2007
    ..Studies of the pathogenesis of sarcoidosis suggest that it is a chronic immunological response produced by a genetic susceptibility and exposure to specific environmental factors...
  67. ncbi Adelmidrol, a palmitoylethanolamide analogue, reduces chronic inflammation in a carrageenin-granuloma model in rats
    Daniele De Filippis
    Universita Federico II, Napoles, Italy
    J Cell Mol Med 13:1086-95. 2009
    ..In this study, we investigated the effect of adelmidrol on granuloma formation induced by lambda-carrageenin-soaked sponge implant in rats...
  68. ncbi Levels of endocannabinoids and palmitoylethanolamide and their pharmacological manipulation in chronic granulomatous inflammation in rats
    D De Filippis
    Department of Experimental Pharmacology, Faculty of Pharmacy, University of Naples Federico II, Via Domenico Montesano 49, 80131 Naples, Italy
    Pharmacol Res 61:321-8. 2010
    ..We investigated the role of the endocannabinoid system during granuloma formation, a model of chronic inflammation sustained by neoangiogenesis, in rats...
  69. ncbi The secret lives of the pathogenic mycobacteria
    Christine L Cosma
    Department of Microbiology, University of Washington, Seattle, Washington 98195, USA
    Annu Rev Microbiol 57:641-76. 2003
    ..This review summarizes our understanding of Mycobacterium-host cell interactions, the bacterial-granuloma interface, and mechanisms of bacterial virulence and persistence...
  70. pmc A diagnostic and therapeutic scheme for a solitary cysticercus granuloma
    G Singh
    Department of Neurology, Dayanand Medical College, Ludhiana, Punjab, India
    Neurology 75:2236-45. 2010
    Solitary cysticercus granuloma (SCG) is one of the most common forms of presentation of neurocysticercosis (NCC). The diagnostic workup and management approach to this condition remain uncertain and controversial.
  71. pmc Genetic control of severe egg-induced immunopathology and IL-17 production in murine schistosomiasis
    Patrick M Smith
    Department of Pathology, Sackler School of Biomedical Sciences, Tufts University School of Medicine, Boston, MA 02111, USA
    J Immunol 183:3317-23. 2009
    ..Egg granuloma size exhibited significant linkage to two loci, D4Mit203 and D17Mit82, both of which were inherited in a BL/6 ..
  72. pmc Granuloma formation is required to contain bacillus growth and delay mortality in mice chronically infected with Mycobacterium tuberculosis
    B M Saunders
    Mycobacteria Research Laboratories, Department of Microbiology, Colorado State University, Fort Collins 80523, USA
    Immunology 98:324-8. 1999
    ..However, even in the absence of any appreciable granuloma formation, these mice control bacterial growth for at least 90 days...
  73. pmc Mouse model of necrotic tuberculosis granulomas develops hypoxic lesions
    Jamie Harper
    Department of Medicine, Center for Infection and Inflammation Imaging Research, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    J Infect Dis 205:595-602. 2012
    ..Preclinical evaluation of tuberculosis drugs is generally limited to mice. However, necrosis and hypoxia, key features of human tuberculosis lesions, are lacking in conventional mouse strains...
  74. ncbi Metabolic profiling of lung granuloma in Mycobacterium tuberculosis infected guinea pigs: ex vivo 1H magic angle spinning NMR studies
    B S Somashekar
    Department of Microbiology, Immunology and Pathology, Colorado State University, Campus Delivery 1682, Fort Collins, Colorado 80523 1682, United States
    J Proteome Res 10:4186-95. 2011
    ..the infiltrating cells that generate much of the metabolites in the increasingly necrotic and hypoxic developing granuloma through the glycolytic, pentose phosphate, and tricarboxylic acid pathways...
  75. ncbi Early granuloma formation after aerosol Mycobacterium tuberculosis infection is regulated by neutrophils via CXCR3-signaling chemokines
    Peter Seiler
    Max Planck Institute for Infection Biology, Department of Immunology, Berlin, Germany
    Eur J Immunol 33:2676-86. 2003
    ..Here we report that PMN are essential for accurate early granuloma formation during chronic M. tuberculosis infection without influencing mycobacterial growth restriction...
  76. pmc Serine protease activity contributes to control of Mycobacterium tuberculosis in hypoxic lung granulomas in mice
    Stephen T Reece
    Department of Immunology, Max Planck Institute for Infection Biology, Berlin, Germany
    J Clin Invest 120:3365-76. 2010
    ..Extrinsic inhibition of serine protease activity in vivo resulted in distorted granuloma structure, extensive hypoxia, and increased bacterial growth in this model...
  77. pmc Dynamic nature of host-pathogen interactions in Mycobacterium marinum granulomas
    D M Bouley
    Department of Comparative Medicine, Stanford University School of Medicine, Stanford, California 94305, USA
    Infect Immun 69:7820-31. 2001
    ..Infection with a mutant bacterial strain with a reduced capacity for intracellular replication shifted the balance, leading to a greatly reduced bacterial burden and inflammatory foci that differed from typical granulomas...
  78. ncbi CD44 regulates hematopoietic progenitor distribution, granuloma formation, and tumorigenicity
    R Schmits
    Amgen Institute, Toronto, Ontario, Canada
    Blood 90:2217-33. 1997
    ..either a compensatory response to CD44 deficiency or an immunoregulatory defect, mice also developed exaggerated granuloma responses to Cryotosporidium parvum infection...
  79. pmc CCL5 participates in early protection against Mycobacterium tuberculosis
    Bridget Vesosky
    Center for Microbial Interface Biology and Department of Veterinary Biosciences, The Ohio State University, 1046 Biomedical Research Tower, 460 West 12th Ave, Columbus, OH 43210, USA
    J Leukoc Biol 87:1153-65. 2010
    ..The chemokines and chemokine receptors that promote cell migration for granuloma formation, however, are not defined completely. As immunity to M...
  80. ncbi Tolerization of mice to Schistosoma mansoni egg antigens causes elevated type 1 and diminished type 2 cytokine responses and increased mortality in acute infection
    P G Fallon
    Department of Pathology, University of Cambridge, United Kingdom
    J Immunol 162:4122-32. 1999
    The granuloma that surrounds the Schistosoma mansoni egg is the cause of pathology in murine schistosomiasis, and its formation is driven by egg Ag-stimulated type 1 and type 2 cytokines...
  81. ncbi Sarcoid-like granulomatosis in patients treated with tumor necrosis factor blockers: 10 cases
    Claire Immediato Daïen
    CHU Lapeyronie, Service d Immuno Rhumatologie, Montpellier, France
    Rheumatology (Oxford) 48:883-6. 2009
    ..However, several cases of sarcoidosis have been diagnosed during anti-TNF therapy. Here, we report the largest series of sarcoid-like granulomatosis following TNF blocker treatment...
  82. ncbi Pharmacological effects of SB 220025, a selective inhibitor of P38 mitogen-activated protein kinase, in angiogenesis and chronic inflammatory disease models
    J R Jackson
    Department of Immunopharmacology, SmithKline Beecham Pharmaceuticals, King of Prussia, Pennsylvania 19406, USA
    J Pharmacol Exp Ther 284:687-92. 1998
    ..A model of inflammatory angiogenesis is the murine air pouch granuloma, which has a hyperangiogenic component...
  83. pmc Foamy macrophages and the progression of the human tuberculosis granuloma
    David G Russell
    Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, New York, USA
    Nat Immunol 10:943-8. 2009
    ..disease that culminates in the transmission of infectious bacilli is determined locally at the level of the granuloma. This progression takes place even in the face of a robust immune response that, although it contains infection, ..
  84. ncbi Immunopathogenesis of human schistosomiasis
    M L Burke
    The Queensland Institute of Medical Research, Herston, Australia
    Parasite Immunol 31:163-76. 2009
    ....
  85. pmc The immune paradox of sarcoidosis and regulatory T cells
    Makoto Miyara
    Institut National de la Santé et de la Recherche Médicale INSERM U543, Immunologie A, 75013 Paris, France
    J Exp Med 203:359-70. 2006
    Sarcoidosis is characterized by extensive local inflammation (granuloma, cytokine secretion) associated with anergy (poor response to antigens in vitro and in vivo)...
  86. ncbi Who puts the tubercle in tuberculosis?
    David G Russell
    Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, New York 14853, USA
    Nat Rev Microbiol 5:39-47. 2007
    ..disease because the TB bacilli are 'walled off' by the immune system inside a tissue nodule known as a granuloma. The granuloma's primary function is one of containment and it prevents the dissemination of the mycobacteria...
  87. pmc In a murine tuberculosis model, the absence of homeostatic chemokines delays granuloma formation and protective immunity
    Shabaana A Khader
    Trudeau Institute, Saranac Lake, NY 12983, USA
    J Immunol 183:8004-14. 2009
    ..also important for the accumulation of Ag-specific IFN-gamma-producing T cells in the lung, development of the granuloma, and control of mycobacteria...
  88. ncbi Evolution of foamy macrophages in the pulmonary granulomas of experimental tuberculosis models
    Neus Caceres
    Department of Microbiology, Fundació Institut per a la Investigació en Ciències de la Salut Germans Trias i Pujol, Badalona, Catalonia, Spain
    Tuberculosis (Edinb) 89:175-82. 2009
    ..models is characterized by the accumulation of foamy macrophages (FM)--which shape the outer ring of the granuloma - in the alveolar spaces, as detected in paraffin-embedded tissues stained with hematoxylin-eosin...
  89. ncbi Life and death in the granuloma: immunopathology of tuberculosis
    Bernadette M Saunders
    Mycobacterial Research Programme, Centenary Institute, Newtown, New South Wales, Australia
    Immunol Cell Biol 85:103-11. 2007
    During tuberculosis (TB) infection, the granuloma provides the microenvironment in which antigen-specific T cells colocate with and activate infected macrophages to inhibit the growth of Mycobacterium tuberculosis...
  90. pmc T cell-derived tumour necrosis factor is essential, but not sufficient, for protection against Mycobacterium tuberculosis infection
    B M Saunders
    Centenary Institute of Cancer Medicine and Cell Biology, Newtown, Australia
    Clin Exp Immunol 137:279-87. 2004
    ..Therefore, both T cell- and macrophage-derived TNF play distinct roles in orchestrating the protective inflammatory response and enhancing survival during M. tuberculosis infection...
  91. ncbi Pathology of postprimary tuberculosis in humans and mice: contradiction of long-held beliefs
    Robert L Hunter
    Department of Pathology and Laboratory Medicine, University of Texas Houston Medical School, MSB 2 136, 6431 Fannin, Houston, TX 77030, USA
    Tuberculosis (Edinb) 87:267-78. 2007
    ..Developing necrosis in both species is associated with localization of organisms within lipid droplets. These results suggest that reactivation tuberculosis in mice is a valuable model of developing human postprimary tuberculosis...
  92. pmc Cytokine-chemokine networks in experimental mycobacterial and schistosomal pulmonary granuloma formation
    Bo Chin Chiu
    Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan, USA
    Am J Respir Cell Mol Biol 29:106-16. 2003
    ..These findings reveal a complex cytokine-chemokine regulatory network that dictates profiles of local chemokine expression during T cell-mediated granuloma formation.
  93. ncbi In infection with Schistosoma mansoni, B cells are required for T helper type 2 cell responses but not for granuloma formation
    H J Hernandez
    Department of Pathology, Tufts University School of Medicine, Boston, MA 02111, USA
    J Immunol 158:4832-7. 1997
    ..These results suggest that B cells promote Th2-type responses, and that typical granulomatous responses proceed in their absence...
  94. pmc Alphabeta T cell receptor-positive cells and interferon-gamma, but not inducible nitric oxide synthase, are critical for granuloma necrosis in a mouse model of mycobacteria-induced pulmonary immunopathology
    S Ehlers
    Division of Molecular Infection Biology, Research Center Borstel, Center for Medicine and Biosciences, D 23845 Borstel, Germany
    J Exp Med 194:1847-59. 2001
    ..In contrast, high mycobacterial load and extensive granulomatous infiltration per se are not sufficient to cause caseation, nor is granuloma necrosis linked to the induction of nitric oxide.
  95. pmc Trehalose 6,6'-dimycolate and lipid in the pathogenesis of caseating granulomas of tuberculosis in mice
    Robert L Hunter
    Department of Pathology and Laboratory Medicine, MSB 2 136, 6431 Fannin, Houston, TX 77030, USA
    Am J Pathol 168:1249-61. 2006
    ..This supports the hypothesis that pulmonary tuberculosis sequesters MTB in a protected environment that accumulates lipid until it is able to activate the toxicity of TDM and initiate necrosis that results in caseating granulomas...
  96. pmc Dynamic imaging of experimental Leishmania donovani-induced hepatic granulomas detects Kupffer cell-restricted antigen presentation to antigen-specific CD8 T cells
    Lynette Beattie
    Department of Biology, Centre for Immunology and Infection, Hull York Medical School, University of York, York, United Kingdom
    PLoS Pathog 6:e1000805. 2010
    ..This restriction of antigen presentation to KCs within the Leishmania granuloma has important implications for the identification of new candidate vaccine antigens and for the design of novel ..
  97. ncbi Granuloma faciale: a clinicopathologic study of 66 patients
    Nicolas Ortonne
    Department of Pathology, Hopital Henri Mondor, Creteil, France
    J Am Acad Dermatol 53:1002-9. 2005
    Only case reports or studies of small series of patients have focused on granuloma faciale (GF).
  98. ncbi Interplay of cysteinyl leukotrienes and TGF-β in the activation of hepatic stellate cells from Schistosoma mansoni granulomas
    Ligia A Paiva
    Laboratory of Immunopharmacology, Institute Oswaldo Cruz, Manguinhos, Rio de Janeiro, RJ, Brazil
    Biochim Biophys Acta 1801:1341-8. 2010
    ....
  99. ncbi Histoarchitecture of schistosomal granuloma development and involution: morphogenetic and biomechanical approaches
    H L Lenzi
    Departamento de Patologia, Instituto Oswaldo Cruz, Rio de Janeiro, Brasil
    Mem Inst Oswaldo Cruz 93:141-51. 1998
    ..The authors concluded that schistosomal granuloma is not a tangled web of individual cells and fibers, but an organized structure composed by host and parasite ..
  100. pmc Temporal and spatial arrangement of lymphocytes within lung granulomas induced by aerosol infection with Mycobacterium tuberculosis
    M Gonzalez-Juarrero
    Mycobacteria Research Laboratories, Department of Microbiology, Colorado State University, Fort Collins, Colorado 80523, USA
    Infect Immun 69:1722-8. 2001
    ..As granuloma formation continued, the granuloma was found to consist of macrophages, CD4, and CD8 T cells, as well as a ..
  101. ncbi Monocyte-derived inflammatory dendritic cells in the granuloma during mycobacterial infection
    Heidi A Schreiber
    Department of Pathology and Laboratory Sciences, University of Wisconsin, Madison, WI 53705, USA
    Adv Exp Med Biol 946:277-93. 2012
    ..cell subset present in Mycobacterium-induced granulomas also influences local immune regulation within the granuloma over the course of infection...

Research Grants75

  1. 5500 QTRAP
    John W Turk; Fiscal Year: 2010
    ..cell wall lipid molecular species and cellular mechanisms of destructive host tissue reactions in a murine granuloma model (Dr. David Russell, Cornell Univ.);(7) Neural mechanisms of olfactory pattern recognition (Dr...
  2. Chronic Granulomatous Lung Inflammation Elicited by Carbon Nanotubes
    Mary Jane Thomassen; Fiscal Year: 2013
    ..This proposal will utilize a novel murine MWCNT-elicited, chronic granuloma model to investigate the impact of carbon nanotubes on specific host receptors, peroxisome proliferator-..
  3. Effect Ultraviolet Radiation on Latent M. tuberculosis Infection in Guinea Pigs
    Amminikutty Jeevan; Fiscal Year: 2010
    ..These studies will be addressed in the low-dose guinea pig model of pulmonary tuberculosis as the disease in these animals closely resembles the human disease. ..
  4. Identification of new compounds against fungal microbes
    Maurizio Del Poeta; Fiscal Year: 2013
    ..synthesis of glucosylceramide (glucosylceramide synthase 1 or Gcs1), after inhalation, was confined in the lung granuloma and, thus, did not reach the bloodstream and did not disseminate to the brain...
  5. Coenzyme F420-dependent enzymes in mycobacteria
    Biswarup Mukhopadhyay; Fiscal Year: 2013
    ..Since the mycobacteria face low redox environments within the human granuloma and soil, they could derive more reducing power from lipid degradation if they use F420 in place of NAD(P);the ..
  6. CHEMOKINE RECEPTOR DYNAMICS IN GRANULOMA FORMATION
    Stephen W Chensue; Fiscal Year: 2013
    ..The studies proposed will aid the design of improved approaches to vaccine development and therapies to control chronic destructive inflammatory responses. ..
  7. Gene regulation and virulence in TB
    WILLIAM RAMSES BISHAI; Fiscal Year: 2013
    ..cAMP intoxication at the cellular level in vitro, in whole lung tissue using the mouse model in vivo, and at the granuloma level using laser-capture microdissection in specialized animal models including the rabbit which display ..
  8. Screening for inhibitors of M. tuberculosis persistence-related lipid metabolism
    Robert B Abramovitch; Fiscal Year: 2013
    ..Of those infected, ~90% mount a successful immune response that sequesters the bacterium in a granuloma. The granuloma limits the spread and growth of the bacterium and results in a persistent infection...
  9. Mechanisms of host-bacterial interactions, ileitis and granuloma formation in Agr
    Steven M Lipkin; Fiscal Year: 2013
    ..Crohn's disease is characterized by transmural intestinal inflammation with granuloma formation...
  10. GRADS Cooperative Research Project: JHU Clinical Center
    David R Moller; Fiscal Year: 2013
    ..These studies may establish links between specific clinical phenotypes, microbial etiologies, and common pathogenic mechanisms to provide a framework for new therapeutic approaches to sarcoidosis. ..
  11. Mycobacterial Dissemination and Persistence
    Jeffrey D Cirillo; Fiscal Year: 2010
    ..The current proposal is focused on understanding how dissemination occurs and its relationship to latency so that we can better treat, prevent and diagnose tuberculosis. ..
  12. Recruitment of CX3CR1-GFP+ monocytes during Schistosoma mansoni infection.
    PNG LOKE; Fiscal Year: 2012
    ..The goal of this project is to identify where these macrophages come from in order to design interventional strategies that could help regulate the inflammatory process during a type 2 response. ..
  13. The Role of CD8 T Cells in Chronic Granulomatous Inflammation
    Kyra A Oswald-Richter; Fiscal Year: 2013
    ....
  14. The Mycobacterium Tuberculosis Dormancy Program
    MARTIN INUA VOSKUIL; Fiscal Year: 2013
    ..Our research is designed to demonstrate the unique metabolic pathway used by M. tuberculosis to survive in a non-replicating state in order to provide mechanisms that can be targeted by novel antimicrobials. ..
  15. Diagnostic Tests and Immunotherapy of Sarcoidosis Using Mycobacterial Proteins
    David R Moller; Fiscal Year: 2012
    ....
  16. Lipid storage and mobilization in M. tuberculosis as antilatency drugs targets
    PAPPACHAN KOLATTUKUDY KOLATTUKUDY; Fiscal Year: 2013
    ..They will also be submitted to TARGET for testing in a hollow fiber artificial granuloma model of dormancy in mice and determine whether storage lipid accumulation is involved in this in vivo dormancy ..
  17. M. tuberculosis genes required for pulmonary survival revealed by TraCS
    MARY HONDALUS; Fiscal Year: 2013
    ..The guinea pig host reproduces many aspects of human tuberculosis including the necrotic, hypoxic granuloma not found in all model systems, for example the mouse. The proposal has two AIMS...
  18. THE PATHOGENESIS OF AUTOIMMUNITY IN A MURINE MODEL OF PRIMARY BILIARY CIRRHOSIS
    MERRILL E GERSHWIN; Fiscal Year: 2010
    ..abstract_text> ..
  19. HIF-1alpha Mediated Wound Healing in Periapical Lesion
    Hajime Sasaki; Fiscal Year: 2013
    ..followed by delayed and polarized M2 macrophage activation, which leads to chronic inflammation and radicular granuloma. Thus, the HIF-1a- mediated response is a target pathway for the development of novel therapeutics for improving ..
  20. Mycobacterium Tuberculosis Lipoarabinomannan In Vivo
    Libin Shi; Fiscal Year: 2013
    ..The definition of the terminal ends of LAM in vivo will impact the future when a sensitive and specific anti-LAM antibody can be generated based on this study to enhance LAM based existing assays for use in resource poor regions. ..
  21. PROTEIN/LIPID INTERACTIONS
    Robert B Gennis; Fiscal Year: 2013
    ..We also plan to address the question about how O2 diffuses through the protein to the active site, and how the pathways for this differ in the A-, B- and C-families of oxygen reductases. ..
  22. Disrupting Biofilm Formation to Improve TB Drug Treatment
    Randall J Basaraba; Fiscal Year: 2013
    ..Finally, we will reveal the mechanisms of action of our current anti-biofilm compounds and the identity of other druggable targets unique to drug-tolerant Mtb. ..
  23. Regulation of Myeloid Development and Function by II-4
    Achsah D Keegan; Fiscal Year: 2010
    ..These cells can play critical roles in granuloma formation and in bone homeostasis. There have been numerous reports describing effects of IL-4 on bone biology...
  24. Role of mycobacteria in sarcoidosis immunopathogenesis
    Wonder Drake; Fiscal Year: 2009
    ..These findings, which will assess in an independent and complementary fashion the role of mycobacteria in sarcoidosis immunopathogenesis, may have an impact on future therapeutic modalities for sarcoidosis. ..
  25. The Use of 68Ga-DOTATOC and 18F-FDG PET/CT Imaging in the Evaluation of Newly Dia
    RONALD CLARK WALKER; Fiscal Year: 2013
    ..Finally we will combine these imaging data with a serum proteomic analysis and other patient information to develop a new multivariate model for the diagnosis of lung cancer. ..
  26. HO-1 and granuloma formation in TB pleurisy
    Veena B Antony; Fiscal Year: 2010
    ..is endemic among patients with AIDS and follows an aggressive course with poor localization of mycobacteria into granuloma and widespread infection...
  27. Impact of CCR5 inhibition on Sarcoid Immunophenotypes
    KEVIN FITZGERALD GIBSON; Fiscal Year: 2013
    ..While the specific causality of sarcoidosis is enigmatic, the granuloma formation and other pathologic findings of this disorder almost certainly reflect a dysregulated immune response ..
  28. Synergy of Host Defense Mechanisms in the Lung
    Arturo Casadevall; Fiscal Year: 2012
    ..Furthermore, these studies will provide information that could be used to design vaccines and new therapies based on immunological reagents such as antibodies. ..
  29. M. Tuberculosis Influences Host Matrix Metalloproteinases and Granuloma Formation
    NICOLE AMMERMAN; Fiscal Year: 2013
    ..tuberculosis is a major AIDS- related opportunistic pathogen. The hallmark feature of tuberculosis, the granuloma, is a defined cellular aggregate within the lung tissue, surrounding and containing the initial focus of ..
  30. Fate and effects of nanomaterials in the gastrointestinal tract
    Celine A Beamer; Fiscal Year: 2012
    ..Pulmonary exposure to CNTs results in oxidative stress, inflammation, granuloma formation, and fibrosis, which may severely impact lung function in affected individuals...
  31. Development of a Cell-Based HTS for Inhibitors of Inflammatory Macrophages
    David G Russell; Fiscal Year: 2013
    ..In tuberculosis this occurs when the granuloma starts to breakdown, culminating in active disease...
  32. Host-Responses to Mycobacterium Infection in Zebrafish
    Lalita Ramakrishnan; Fiscal Year: 2013
    ..uninfected macrophages are then recruited, and aggregate into the hallmark pathological structure of TB, the granuloma. Long thought to be a host beneficial structure that walls off the infection, we have found that the granuloma, ..
  33. Immunochemotherapy in Visceral Leishmaniasis
    Henry W Murray; Fiscal Year: 2013
    ..Aim 1 tests mechanisms which govern responses to drug within the assembled tissue granuloma: mononuclear cell recruitment by potentially therapeutic chemokines, GM-CSF-induced blood monocyte influx and ..
  34. Targeting matrix metalloproteinases to limit immunopathology in airborne infectio
    SUWAN JAYASINGHE; Fiscal Year: 2013
    ..g., SARS coronavirus). We will establish a new therapeutic paradigm targeting excessive host MMP activity to improve outcomes in pulmonary infection. ..
  35. Macrophage PPARg signaling, efferocytosis, and exaggerated inflammation in CGD
    Donna L Bratton; Fiscal Year: 2011
    ..g. obstructing granuloma, colitis and autoimmunity)...
  36. cAMP signaling pathways within Mycobacterium tuberculosis
    Kathleen A McDonough; Fiscal Year: 2013
    ....
  37. A multi-scale model to predict outcomes of immunomodulation and drug therapy duri
    JENNIFER JEAN LINDERMAN; Fiscal Year: 2013
    ..Yet bacilli can survive within granuloma for years...
  38. Reactivated tuberculosis in SIV-infected cynomolgus macaques
    Joshua T Mattila; Fiscal Year: 2010
    ..other factors, including cytokines and chemokines, are required to coordinate cellular activities maintain the granuloma integrity...
  39. GENETIC BASIS OF MYCOBACTERIAL INVASION
    Lalita Ramakrishnan; Fiscal Year: 2013
    ..tuberculosis-like disease in ectotherms, and a peripheral granulomatous disease in humans called fish tank granuloma. M...
  40. Innate Immunity in Experimental Arthritis of Kininogen
    Robert Colman; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  41. Mycobacterium tuberculosis evasion of CD4+ T cells in vivo
    Joel D Ernst; Fiscal Year: 2013
    ..We expect that understanding these mechanisms will allow us and others to develop novel ways to increase resistance of people to tuberculosis. ..
  42. Transcriptomics of Tuberculosis Latency and Reactivation in Primates
    Deepak Kaushal; Fiscal Year: 2013
    ..The central hypothesis of our proposal is that host granuloma responses can be used to predict latent and reactivation TB...
  43. The role of Mycobacterium marinum protein ESAT-6 in promoting granuloma formation
    Frances Chu; Fiscal Year: 2011
    ..infected macrophages then recruit additional macrophages and other immune cells to the infection foci to form a granuloma, an organized aggregate of immune cells that is a hallmark of tuberculous infections...
  44. WTC Dust Size and Alkalinity as Factors in First Responder Chronic Lung Ailments
    Mitchell D Cohen; Fiscal Year: 2012
    ..reduced, and (B) metals associated with the now-retained WTC particles exerted a variety of toxicities including granuloma induction and promotion of ongoing airway remodeling...
  45. Mycobacterium tuberculosis evasion of CD4+ T cells in vivo
    JOEL ERNST; Fiscal Year: 2009
    ..tuberculosis to evade elimination by the mammalian adaptive immune response, and will guide future efforts to develop the means to increase human resistance to tuberculosis. ..
  46. Significance Circulating Semaphorin 7a+ve Cells in Pulmonary Sarcoidosis
    Erica L Herzog; Fiscal Year: 2013
    ..between unidentified genetic, infectious, and/or environmental factors that combine to induce ongoing granuloma formation in affected tissues...
  47. T CELLS IN GRANULOMATOUS IMMUNE RESPONSES
    Matyas Sandor; Fiscal Year: 2011
    ..Under the aegis of our previous funding period, we have developed new granuloma models and technologies to study them...
  48. M.tb Survival Regulatory Genes
    WILLIAM RAMSES BISHAI; Fiscal Year: 2013
    ..It will assess the role Rv0386-cAMP signaling on granuloma formation specifically focusing on the induction of MMP secretion by Rv0386-dependent mechanisms (Aim 2)...
  49. UPLC with Tandem MS for Sensitive Quantitative Analysis of Small Molecules
    Michelle A Rudek; Fiscal Year: 2010
    ....
  50. Macrophage Differentiation in Acute and Chronic Helminth Infection.
    Natasha M Girgis; Fiscal Year: 2013
    ....
  51. Secondary Analysis of Four Trichiasis Surgery Clinical Trials to Inform Managemen
    Emily W Gower; Fiscal Year: 2013
    ..In addition, this project is aligned with the United Nations'Millennium Development Goals, which focuses on reducing poverty, hunger, and disease. ..
  52. Targeting Oxidative Stress in Chronic Beryllium Disease
    Lisa A Maier; Fiscal Year: 2013
    ..The molecular mechanisms by which beryllium regulates the chronic production of lung inflammation and granuloma formation are unknown...
  53. THE ROLE OF THE GRANULOMA IN M. TUBERCULOSIS INFECTIONS
    David G Russell; Fiscal Year: 2013
    ..Progression of a granuloma is marked by destructive tissue remodeling, and culminates in the release of infectious bacilli into the airways ..
  54. Sarcoidosis and A1AT Genomics &Informatics Center
    Stephen R Wisniewski; Fiscal Year: 2013
    ..2: Novel molecular phenotypes in Sarcoidosis - will address the hypothesis that systemic Inflammation as reflected in gene expression changes in PBMC Is indicative of disease extent, microbiome shifts and granuloma molecular networks.
  55. A multi-scale and multi-system approach to understand granuloma formation in TB
    STEVEN LYNN KUNKEL; Fiscal Year: 2010
    ..A key outcome is the formation of a collection of immune cells termed the granuloma. This structure acts not only as an immune microenvironment and a barrier to dissemination but also as a niche ..
  56. TLR2 and the Tubercle Granuloma
    Padmini Salgame; Fiscal Year: 2013
    ..receptor 2 (TLR2) is the master regulator controlling both protective and pathologic features of the tubercle granuloma. The hypothesis builds on novel findings made in our laboratory...
  57. Discovery of marine natural products targeting latent M. tuberculosis
    Kyle H Rohde; Fiscal Year: 2013
    ..TB exhibit phenotypic drug resistance due to metabolic and structural adaptations to conditions within pulmonary granuloma lesions...
  58. Significance of Notch1 and Tribbles-2 in macrophage fusion and granuloma formatio
    Andras Schaffer; Fiscal Year: 2012
    ..Therefore, understanding the mechanisms underlying macrophage differentiation and granuloma formation is of particular importance to medicine, and designing novel therapeutics to modulate macrophage-..
  59. Immunochemotherapy in Visceral Leishmaniasis
    Henry Murray; Fiscal Year: 2009
    ..Aim 1 examines untested Th1-type mechanisms which likely govern responses to drug within the assembled tissue granuloma. Methods focus on mononuclear cell recruitment by potentially therapeutic chemokines, GM-CSF-induced blood ..
  60. Characterization of Toxicity with Spinal Opiates
    Tony L Yaksh; Fiscal Year: 2010
    ..no effect upon the spinal parenchyma, but led to the concentration and time dependent development of an aseptic granuloma (neutrophils and macrophages) proximal to the catheter tip, arising from the dura-arachnoid layer...
  61. FIBROSIS IN CROHNS DISEASE--ROLE OF IGF I
    ELLEN ZIMMERMANN; Fiscal Year: 1999
    ..We will determine the changes in intestinal inflammation and fibrosis resulting from modulation of IGF-I to lend insight into the in vivo roles of IGF-I in mediating intestinal fibrosis. ..
  62. NEMATODE-INDUCED PULMONARY GRANULOMA FORMATION
    STEPHEN KAYES; Fiscal Year: 1991
    ..been carried out to dissect the role of splenic T lymphocytes in the regulation of Toxocara- specific pulmonary granuloma formation with no success...
  63. Neuropeptides in the pathogenesis of neurocysticercosis
    Prema Robinson; Fiscal Year: 2007
    ..The neuropeptide substance P (SP) stimulates granuloma growth and Th1 cytokine production...
  64. GRANULOMA REGULATION THROUGH SOMATOSTATIN RECEPTOR SSTR2
    David Elliott; Fiscal Year: 2000
    ..In turn, other inflammatory cells types regulate granuloma T cells. Diseases like IBD develop when there is disruption of this cross regulatory circuitry...
  65. Regulation of host response genes in pathogenesis of TB
    Jesse Roman; Fiscal Year: 2005
    ..of new effective chemotherapeutic agents are due in part to the limited knowledge about host genes that control granuloma formation and other aspects of the host's response to this pathogen in lung...
  66. Matrix Metalloproteinases and PPAR Gamma in Sarcoidosis
    Daniel Culver; Fiscal Year: 2009
    ..since they are capable of facilitating extracellular matrix remodeling, activating cytokines important in granuloma formation and releasing growth factors...
  67. OXIDANT INDUCED BETA CHEMOKINES IN GRANULOMA FORMATION
    Jeffrey Warren; Fiscal Year: 2000
    ..g. Wegener's granulomatosis, sarcoidosis). Central to granuloma formation is the coordinated recruitment of mononuclear phagocytes, and in some types of lesions...
  68. Reflux Disease in Patients with Throat Signs/Symptoms
    Michael Vaezi; Fiscal Year: 2005
    ..cough commonly shows laryngeal abnormalities including laryngitis and vocal cord lesions including polyps, granuloma and carcinoma. Gastroesophageal reflux disease often is proposed as the etiology of these abnormalities...
  69. MONOCYTE RECRUITMENT IN PLEUROPULMONARY TB IN AIDS
    Veena Antony; Fiscal Year: 2005
    ..is endemic among patients with AIDS and follows an aggressive course with poor localization of mycobacteria into granuloma and widespread infection...
  70. ROLE OF ANTI-PROTEINASE-3 IN WEGENER'S VASCULOPATHY
    Judith James; Fiscal Year: 2003
    ..etiology which is characterized by small to medium vessel vasculitis, pauci-immune glomerulonephritis, necrosis/granuloma formation of the respiratory tracts and autoantibodies to neutrophilic components...
  71. IMMUNOLOGIC REGULATION OF PULMONARY FIBROSIS
    Robert Mason; Fiscal Year: 2001
    ..we hypothesize that there is less fibrosis in granulomatous lung disease because of factors within the granuloma that suppress the fibrotic response, specifically interferon- gamma (IFNgamma) and keratinocyte growth factor (..
  72. CELLULAR MECHANISMS IN ATHEROGENESIS
    COLIN SCHWARTZ; Fiscal Year: 1992
    ..This project will isolate, purify, and characterize the Ac-LDL receptor of rabbit granuloma macrophages, including its complete primary amino acid sequence...