fibrosis

Summary

Summary: Any pathological condition where fibrous connective tissue invades any organ, usually as a consequence of inflammation or other injury.

Top Publications

  1. pmc The myofibroblast: one function, multiple origins
    Boris Hinz
    Laboratory of Cell Biophysics, Ecole Polytechnique Federale de Lausanne EPFL, Bâtiment SG AA B143, Station 15, CH 1015 Lausanne, Switzerland
    Am J Pathol 170:1807-16. 2007
  2. pmc Cellular and molecular mechanisms of fibrosis
    T A Wynn
    Immunopathogenesis Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Pathol 214:199-210. 2008
  3. pmc Mechanisms of fibrosis: therapeutic translation for fibrotic disease
    Thomas A Wynn
    Immunopathogenesis Section, Program in Barrier Immunity and Repair, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
    Nat Med 18:1028-40. 2012
  4. pmc Evidence that fibroblasts derive from epithelium during tissue fibrosis
    Masayuki Iwano
    Department of Medicine, Vanderbilt University, Nashville, Tennessee, USA
    J Clin Invest 110:341-50. 2002
  5. ncbi TGF-beta signaling and the fibrotic response
    Andrew Leask
    Centre for Rheumatology, Department of Medicine, Royal Free and University College Medical School, Rowland Hill St, London, UK NW3 2PF
    FASEB J 18:816-27. 2004
  6. ncbi Transforming growth factor beta in tissue fibrosis
    W A Border
    Division of Nephrology, University of Utah School of Medicine, Salt Lake City 84132
    N Engl J Med 331:1286-92. 1994
  7. pmc Common and unique mechanisms regulate fibrosis in various fibroproliferative diseases
    Thomas A Wynn
    Immunopathogenesis Section, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892, USA
    J Clin Invest 117:524-9. 2007
  8. pmc Fate tracing reveals the pericyte and not epithelial origin of myofibroblasts in kidney fibrosis
    Benjamin D Humphreys
    Renal Division, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Am J Pathol 176:85-97. 2010
  9. ncbi miR-133 and miR-30 regulate connective tissue growth factor: implications for a role of microRNAs in myocardial matrix remodeling
    Rudy F Duisters
    Department of Cardiology, Cardiovascular Research Institute Maastricht, University of Maastricht, The Netherlands
    Circ Res 104:170-8, 6p following 178. 2009
  10. pmc Diverse roles of TGF-β/Smads in renal fibrosis and inflammation
    Hui Yao Lan
    Li Ka Shing Institute of Health Sciences and Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong SAR, China
    Int J Biol Sci 7:1056-67. 2011

Detail Information

Publications350 found, 100 shown here

  1. pmc The myofibroblast: one function, multiple origins
    Boris Hinz
    Laboratory of Cell Biophysics, Ecole Polytechnique Federale de Lausanne EPFL, Bâtiment SG AA B143, Station 15, CH 1015 Lausanne, Switzerland
    Am J Pathol 170:1807-16. 2007
    ..This review discusses the pattern of myofibroblast accumulation and fibrosis evolution during lung and liver fibrosis as well as during atheromatous plaque formation...
  2. pmc Cellular and molecular mechanisms of fibrosis
    T A Wynn
    Immunopathogenesis Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Pathol 214:199-210. 2008
    b>Fibrosis is defined by the overgrowth, hardening, and/or scarring of various tissues and is attributed to excess deposition of extracellular matrix components including collagen...
  3. pmc Mechanisms of fibrosis: therapeutic translation for fibrotic disease
    Thomas A Wynn
    Immunopathogenesis Section, Program in Barrier Immunity and Repair, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
    Nat Med 18:1028-40. 2012
    b>Fibrosis is a pathological feature of most chronic inflammatory diseases. Fibrosis, or scarring, is defined by the accumulation of excess extracellular matrix components...
  4. pmc Evidence that fibroblasts derive from epithelium during tissue fibrosis
    Masayuki Iwano
    Department of Medicine, Vanderbilt University, Nashville, Tennessee, USA
    J Clin Invest 110:341-50. 2002
    Interstitial fibroblasts are principal effector cells of organ fibrosis in kidneys, lungs, and liver...
  5. ncbi TGF-beta signaling and the fibrotic response
    Andrew Leask
    Centre for Rheumatology, Department of Medicine, Royal Free and University College Medical School, Rowland Hill St, London, UK NW3 2PF
    FASEB J 18:816-27. 2004
    ....
  6. ncbi Transforming growth factor beta in tissue fibrosis
    W A Border
    Division of Nephrology, University of Utah School of Medicine, Salt Lake City 84132
    N Engl J Med 331:1286-92. 1994
  7. pmc Common and unique mechanisms regulate fibrosis in various fibroproliferative diseases
    Thomas A Wynn
    Immunopathogenesis Section, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892, USA
    J Clin Invest 117:524-9. 2007
    ..impact on human health, there are currently no approved treatments that directly target the mechanism(s) of fibrosis. The primary goals of this Review series on fibrotic diseases are to discuss some of the major fibroproliferative ..
  8. pmc Fate tracing reveals the pericyte and not epithelial origin of myofibroblasts in kidney fibrosis
    Benjamin D Humphreys
    Renal Division, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Am J Pathol 176:85-97. 2010
    ..myofibroblasts, we used Cre/Lox techniques to genetically label and fate map renal epithelia in models of kidney fibrosis. Genetically labeled primary proximal epithelial cells cultured in vitro from these mice readily induce markers ..
  9. ncbi miR-133 and miR-30 regulate connective tissue growth factor: implications for a role of microRNAs in myocardial matrix remodeling
    Rudy F Duisters
    Department of Cardiology, Cardiovascular Research Institute Maastricht, University of Maastricht, The Netherlands
    Circ Res 104:170-8, 6p following 178. 2009
    ..notably hypertrophy of cardiac myocytes and an increase in extracellular matrix proteins, often seen as primary fibrosis. Connective tissue growth factor (CTGF) is a key molecule in the process of fibrosis and therefore seems an ..
  10. pmc Diverse roles of TGF-β/Smads in renal fibrosis and inflammation
    Hui Yao Lan
    Li Ka Shing Institute of Health Sciences and Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong SAR, China
    Int J Biol Sci 7:1056-67. 2011
    TGF-β1 has been long considered as a key mediator in renal fibrosis and induces renal scarring largely by activating its downstream Smad signaling pathway...
  11. pmc Epithelial-mesenchymal transition and its implications for fibrosis
    Raghu Kalluri
    Center for Matrix Biology, Beth Israel Deaconess Medical Center, 330 Brookline Ave DANA 514, Boston, Massachusetts 02215, USA
    J Clin Invest 112:1776-84. 2003
    ..studied in the context of embryonic development, it also plays a role in the genesis of fibroblasts during organ fibrosis in adult tissues...
  12. ncbi TGF-β signaling in fibrosis
    Anna Biernacka
    Division of Cardiology, Albert Einstein College of Medicine, Bronx, NY 14016, USA
    Growth Factors 29:196-202. 2011
    ..models have demonstrated the involvement of the canonical activin receptor-like kinase 5/Smad3 pathway in fibrosis. Smad-independent pathways may regulate Smad activation and, under certain conditions, may directly transduce ..
  13. ncbi Cellular and molecular mechanisms of renal fibrosis
    Youhua Liu
    Department of Pathology, University of Pittsburgh, S 405 Biomedical Science Tower, 200 Lothrop Street, Pittsburgh, PA 15261, USA
    Nat Rev Nephrol 7:684-96. 2011
    Renal fibrosis, particularly tubulointerstitial fibrosis, is the common final outcome of almost all progressive chronic kidney diseases...
  14. pmc Origin and function of myofibroblasts in kidney fibrosis
    Valerie S LeBleu
    Department of Cancer Biology, Metastasis Research Center, University of Texas MD Anderson Cancer Center, Houston, Texas, USA
    Nat Med 19:1047-53. 2013
    Myofibroblasts are associated with organ fibrosis, but their precise origin and functional role remain unknown...
  15. pmc Recent developments in myofibroblast biology: paradigms for connective tissue remodeling
    Boris Hinz
    Laboratory of Tissue Repair and Regeneration, Matrix Dynamics Group, Faculty of Dentistry, University of Toronto, Toronto, Ontario, Canada
    Am J Pathol 180:1340-55. 2012
    ..features of the myofibroblast in diverse fibrotic lesions, such as systemic sclerosis; kidney, liver, and lung fibrosis; and the stromal reaction to certain epithelial tumors...
  16. ncbi Increased Wnt signaling during aging alters muscle stem cell fate and increases fibrosis
    Andrew S Brack
    Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA
    Science 317:807-10. 2007
    ..potential of skeletal muscle declines with age, and this impairment is associated with an increase in tissue fibrosis. We show that muscle stem cells (satellite cells) from aged mice tend to convert from a myogenic to a fibrogenic ..
  17. ncbi New insights into epithelial-mesenchymal transition in kidney fibrosis
    Youhua Liu
    Department of Pathology, University of Pittsburgh School of Medicine, S 405 Biomedical Science Tower, 200 Lothrop Street, Pittsburgh, PA 15261, USA
    J Am Soc Nephrol 21:212-22. 2010
    ..However, the degree to which this process contributes to kidney fibrosis remains a matter of intense debate and is likely to be context-dependent...
  18. pmc Evolving therapies for liver fibrosis
    Detlef Schuppan
    Institute of Molecular and Translational Medicine and Department of Medicine I, University Medical Center, Johannes Gutenberg University Mainz, Mainz, Germany
    J Clin Invest 123:1887-901. 2013
    b>Fibrosis is an intrinsic response to chronic injury, maintaining organ integrity when extensive necrosis or apoptosis occurs. With protracted damage, fibrosis can progress toward excessive scarring and organ failure, as in liver cirrhosis...
  19. ncbi Mechanisms of tubulointerstitial fibrosis
    Michael Zeisberg
    Division of Matrix Biology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    J Am Soc Nephrol 21:1819-34. 2010
    The pathologic paradigm for renal progression is advancing tubulointerstitial fibrosis. Whereas mechanisms underlying fibrogenesis have grown in scope and understanding in recent decades, effective human treatment to directly halt or even ..
  20. ncbi Ureteral obstruction as a model of renal interstitial fibrosis and obstructive nephropathy
    Robert L Chevalier
    Department of Pediatrics, University of Virginia, Charlottesville, 22908, USA
    Kidney Int 75:1145-52. 2009
    Renal fibrosis is the hallmark of progressive renal disease of virtually any etiology. The model of unilateral ureteral obstruction (UUO) in the rodent generates progressive renal fibrosis...
  21. ncbi TGF-beta-induced EMT: mechanisms and implications for fibrotic lung disease
    Brigham C Willis
    Heart and Lung Institute, St Joseph s Hospital and Medical Center, Phoenix, Arizona, USA
    Am J Physiol Lung Cell Mol Physiol 293:L525-34. 2007
    ..The extent to which this process contributes to fibrosis following injury in the lung is a subject of active investigation...
  22. ncbi Renal fibrosis: new insights into the pathogenesis and therapeutics
    Youhua Liu
    Division of Cellular and Molecular Pathology, Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Kidney Int 69:213-7. 2006
    Renal fibrosis is the inevitable consequence of an excessive accumulation of extracellular matrix that occurs in virtually every type of chronic kidney disease...
  23. ncbi Peripheral blood fibrocytes: differentiation pathway and migration to wound sites
    R Abe
    Laboratory of. Vascular Biology and Medical Biochemistry, The Picower Institute for Medical Research, Manhasset, NY 11030, USA
    J Immunol 166:7556-62. 2001
    ..These data provide important insight into the control of fibrocyte differentiation and trafficking during tissue repair and significantly expand their potential role during wound healing...
  24. pmc TGF-β signaling in tissue fibrosis: redox controls, target genes and therapeutic opportunities
    Rohan Samarakoon
    Center for Cell Biology and Cancer Research, Albany Medical College, 47 New Scotland Avenue, Albany, NY 12208, USA
    Cell Signal 25:264-8. 2013
    ..Targeting ROS and ROS-activated cellular events is likely to have therapeutic implications in the management of fibrotic disorders, particularly in the context of prolonged TGF-β1 signaling...
  25. pmc Myofibroblast differentiation during fibrosis: role of NAD(P)H oxidases
    Jeffrey L Barnes
    Division of Nephrology, Department of Medicine, University of Texas Health Science Center, San Antonio, Texas 78229 3900, USA
    Kidney Int 79:944-56. 2011
    Progression of fibrosis involves interstitial hypercellularity, matrix accumulation, and atrophy of epithelial structures, resulting in loss of normal function and ultimately organ failure...
  26. pmc Epithelial Notch signaling regulates interstitial fibrosis development in the kidneys of mice and humans
    Bernhard Bielesz
    Department of Medicine, Division of Nephrology, Albert Einstein College of Medicine, New York, New York 10461, USA
    J Clin Invest 120:4040-54. 2010
    Chronic kidney disease is a leading cause of death in the United States. Tubulointerstitial fibrosis (TIF) is considered the final common pathway leading to end-stage renal disease (ESRD)...
  27. pmc Extracellular volume imaging by magnetic resonance imaging provides insights into overt and sub-clinical myocardial pathology
    Martin Ugander
    Cardiovascular and Pulmonary Branch, National Heart, Lung and Blood Institute, National Institutes of Health, US Department of Health and Human Services, 10 Center Drive, Bethesda, MD 20892 1061, USA
    Eur Heart J 33:1268-78. 2012
    ..LGE) cardiac magnetic resonance can detect myocardial infarction and some forms of non-ischaemic myocardial fibrosis. However, quantitative imaging of extracellular volume fraction (ECV) may be able to detect subtle abnormalities ..
  28. pmc Arginase-1-expressing macrophages suppress Th2 cytokine-driven inflammation and fibrosis
    John T Pesce
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD, USA
    PLoS Pathog 5:e1000371. 2009
    Macrophage-specific expression of Arginase-1 is commonly believed to promote inflammation, fibrosis, and wound healing by enhancing L-proline, polyamine, and Th2 cytokine production...
  29. pmc Targeted disruption of TGF-beta1/Smad3 signaling protects against renal tubulointerstitial fibrosis induced by unilateral ureteral obstruction
    Misako Sato
    Department of Pathology, Wakayama Medical University, Wakayama, Japan
    J Clin Invest 112:1486-94. 2003
    Tubulointerstitial fibrosis is the final common result of a variety of progressive injuries leading to chronic renal failure...
  30. pmc Metabolic dysregulation and adipose tissue fibrosis: role of collagen VI
    Tayeba Khan
    Department of Cell Biology, Diabetes Research Center, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Mol Cell Biol 29:1575-91. 2009
    ..extracellular matrix components in adipose tissue in the diabetic state, therefore implicating "adipose tissue fibrosis" as a hallmark of metabolically challenged adipocytes...
  31. pmc ECM remodeling in hypertensive heart disease
    Bradford C Berk
    Cardiovascular Research Institute and Department of Medicine, University of Rochester, Rochester, NY 14642, USA
    J Clin Invest 117:568-75. 2007
    ..Two key aspects of heart failure secondary to HHD are the relatively highly prevalent LV hypertrophy and cardiac fibrosis, caused by changes in the local and systemic neurohormonal environment...
  32. pmc Macrophage-stimulated cardiac fibroblast production of IL-6 is essential for TGF β/Smad activation and cardiac fibrosis induced by angiotensin II
    Feifei Ma
    Beijing An Zhen Hospital, Affiliated to Capital Medical University, Beijing Institute of Heart, Lung, and Blood Vessel Diseases, Beijing, China
    PLoS ONE 7:e35144. 2012
    ..IL-6 has been associated with cardiovascular remodeling. However, the mechanism of IL-6 in hypertensive cardiac fibrosis is still unclear. Angiotensin II (Ang II) infusion in mice increased IL-6 expression in the heart...
  33. pmc Understanding fibrosis in systemic sclerosis: shifting paradigms, emerging opportunities
    Swati Bhattacharyya
    Division of Rheumatology, Department of Medicine, Feinberg School of Medicine, Northwestern University, McGaw M300, 240 East Huron Street, Chicago, IL 60611, USA
    Nat Rev Rheumatol 8:42-54. 2012
    b>Fibrosis in multiple organs is a prominent pathological finding and distinguishing hallmark of systemic sclerosis (SSc)...
  34. ncbi Potential therapeutic targets for cardiac fibrosis: TGFbeta, angiotensin, endothelin, CCN2, and PDGF, partners in fibroblast activation
    Andrew Leask
    Dental Sciences Building, London ON N6A 5C1, Canada
    Circ Res 106:1675-80. 2010
    b>Fibrosis is one of the largest groups of diseases for which there is no therapy but is believed to occur because of a persistent tissue repair program...
  35. ncbi Evaluation of diffuse myocardial fibrosis in heart failure with cardiac magnetic resonance contrast-enhanced T1 mapping
    Leah Iles
    Alfred Hospital and Baker IDI Heart and Diabetes Institute, Melbourne, Australia
    J Am Coll Cardiol 52:1574-80. 2008
    The purpose of this study was to investigate a noninvasive method for quantifying diffuse myocardial fibrosis with cardiac magnetic resonance imaging (CMRI).
  36. ncbi Epithelial to mesenchymal transition and peritoneal membrane failure in peritoneal dialysis patients: pathologic significance and potential therapeutic interventions
    Luiz S Aroeira
    Unidad de Biologia Molecular, Hospital Universitario de la Princesa, C Diego de Leon 62, Madrid, Spain
    J Am Soc Nephrol 18:2004-13. 2007
    ..cause acute and chronic inflammation and injury to the peritoneal membrane, which progressively undergoes fibrosis and angiogenesis and, ultimately, ultrafiltration failure...
  37. ncbi Renal microenvironments and macrophage phenotypes determine progression or resolution of renal inflammation and fibrosis
    Hans Joachim Anders
    Department of Nephrology, Medizinische Poliklinik der LMU, University of Munich, Munich, Germany
    Kidney Int 80:915-25. 2011
    Chronic kidney disease involves renal inflammation, interstitial fibrosis, and tubular and vascular atrophy. Macrophages seem to foster all of these histomorphological abnormalities, but their specific contributions remain controversial...
  38. pmc Systemic sclerosis: a prototypic multisystem fibrotic disorder
    John Varga
    Devision of Rheumatology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
    J Clin Invest 117:557-67. 2007
    ..distinguishes it from other fibrotic disorders is that autoimmunity and vasculopathy characteristically precede fibrosis. Moreover, fibrosis in SSc is not restricted to a single organ, but rather affects many organs and accounts for ..
  39. pmc Activating transcription factor 3 deficiency promotes cardiac hypertrophy, dysfunction, and fibrosis induced by pressure overload
    Heng Zhou
    Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, China
    PLoS ONE 6:e26744. 2011
    ..ATF3 deficiency promoted cardiac hypertrophy, dysfunction and fibrosis after 4 weeks of AB compared to the wild type (WT) mice...
  40. pmc Renal fibrosis is attenuated by targeted disruption of KCa3.1 potassium channels
    Ivica Grgic
    Department of Internal Medicine and Nephrology, Philipps University, 35033 Marburg, Germany
    Proc Natl Acad Sci U S A 106:14518-23. 2009
    Proliferation of interstitial fibroblasts is a hallmark of progressive renal fibrosis commonly resulting in chronic kidney failure. The intermediate-conductance Ca(2+)-activated K(+) channel (K(Ca)3...
  41. ncbi Association of fibrosis with mortality and sudden cardiac death in patients with nonischemic dilated cardiomyopathy
    Ankur Gulati
    Royal Brompton Hospital, London, England
    JAMA 309:896-908. 2013
    ..Superior prognostic factors may improve patient selection for implantable cardioverter-defibrillators (ICDs) and other management decisions...
  42. ncbi Molecular mechanisms that control interstitial fibrosis in the pressure-overloaded heart
    Esther E Creemers
    Heart Failure Research Center, Academic Medical Center, Meibergdreef 15, Room L2 108 3, 1105 AZ Amsterdam, The Netherlands
    Cardiovasc Res 89:265-72. 2011
    ..When this culminates in excessive fibrosis, myocardial compliance decreases and electrical conduction is affected...
  43. pmc Assessment of myocardial fibrosis with cardiovascular magnetic resonance
    Nathan Mewton
    Division of Cardiology, Johns Hopkins University, Baltimore, Maryland 21287 0409, USA
    J Am Coll Cardiol 57:891-903. 2011
    Diffuse interstitial or replacement myocardial fibrosis is a common feature of a broad variety of cardiomyopathies...
  44. pmc Epithelial-mesenchymal transition in renal fibrosis - evidence for and against
    Maria Fragiadaki
    Imperial College Kidney and Transplant Institute, Imperial College London, Hammersmith Hospital, London, UK
    Int J Exp Pathol 92:143-50. 2011
    ..the mesenchymal cells formed could give rise to myofibroblasts which populate the renal interstitium, causing fibrosis within it...
  45. pmc Quantification of diffuse myocardial fibrosis and its association with myocardial dysfunction in congenital heart disease
    Craig S Broberg
    Adult Congenital Heart Disease Program, Oregon Health and Science University, Portland, Ore, USA
    Circ Cardiovasc Imaging 3:727-34. 2010
    the etiology of ventricular dysfunction in adult congenital heart disease (ACHD) is not well understood. Diffuse fibrosis is a likely common final pathway and is quantifiable using MRI.
  46. ncbi Metformin against TGFβ-induced epithelial-to-mesenchymal transition (EMT): from cancer stem cells to aging-associated fibrosis
    Sílvia Cufí
    Catalan Institute of Oncology, Girona
    Cell Cycle 9:4461-8. 2010
    ..Chronic diseases exhibiting excessive fibrosis can be caused by repeated and sustained infliction of TGFb-driven EMT, which increases collagen and extracellular ..
  47. ncbi Mesenchymal conversion of mesothelial cells as a mechanism responsible for high solute transport rate in peritoneal dialysis: role of vascular endothelial growth factor
    Luiz S Aroeira
    Servicio de Nefrologia, Hospital Universitario de la Princesa, Madrid, Spain
    Am J Kidney Dis 46:938-48. 2005
    ..exposed to bioincompatible dialysis fluids that cause epithelial-to-mesenchymal transition of mesothelial cells, fibrosis, and angiogenesis...
  48. pmc Inflammation and EMT: an alliance towards organ fibrosis and cancer progression
    Jose Miguel Lopez-Novoa
    Departamento de Fisiologia y Farmacologia, Universidad de Salamanca, Edificio Departamental, Campus Miguel de Unamuno, Salamanca, Spain
    EMBO Mol Med 1:303-14. 2009
    ..advances in our understanding of the molecular pathways that govern the association of inflammation with organ fibrosis and cancer point to the epithelial to mesenchymal transition (EMT) as the common link in the progression of these ..
  49. ncbi Paricalcitol attenuates renal interstitial fibrosis in obstructive nephropathy
    Xiaoyue Tan
    Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    J Am Soc Nephrol 17:3382-93. 2006
    ..Compared with vehicle controls, paricalcitol significantly attenuated renal interstitial fibrosis in mouse kidney after ureteral obstruction, as demonstrated by a reduced interstitial volume, decreased collagen ..
  50. pmc Fibroblasts in kidney fibrosis emerge via endothelial-to-mesenchymal transition
    Elisabeth M Zeisberg
    Division of Matrix Biology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    J Am Soc Nephrol 19:2282-7. 2008
    Fibroblasts are key mediators of fibrosis in the kidney and other organs, but their origin during fibrosis is still not completely clear...
  51. pmc Inhalation vs. aspiration of single-walled carbon nanotubes in C57BL/6 mice: inflammation, fibrosis, oxidative stress, and mutagenesis
    A A Shvedova
    Health Effects Laboratory Div, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA
    Am J Physiol Lung Cell Mol Physiol 295:L552-65. 2008
    ..mice caused dose-dependent granulomatous pneumonia, oxidative stress, acute inflammatory/cytokine responses, fibrosis, and decrease in pulmonary function...
  52. ncbi TGF-beta and fibrosis in different organs - molecular pathway imprints
    Dirk Pohlers
    Experimental Rheumatology Unit, Department of Orthopedics, Waldkrankenhaus Rudolf Elle Eisenberg, University Hospital Jena, Friedrich Schiller University, Jena, Germany
    Biochim Biophys Acta 1792:746-56. 2009
    ..Thus, TGF-beta is important for the induction of fibrosis often associated with chronic phases of inflammatory diseases...
  53. ncbi Renal fibrosis: novel insights into mechanisms and therapeutic targets
    Peter Boor
    Department of Nephrology, RWTH University of Aachen, Pauwelsstrasse 30, 52074 Aachen, Germany
    Nat Rev Nephrol 6:643-56. 2010
    Renal fibrosis is the common end point of virtually all progressive kidney diseases...
  54. pmc Suppression of microRNA-29 expression by TGF-β1 promotes collagen expression and renal fibrosis
    Bo Wang
    JDRF Danielle Alberti Memorial Centre for Diabetes Complications, Diabetes Division, Baker IDI Heart and Diabetes Institute, Melbourne, Australia
    J Am Soc Nephrol 23:252-65. 2012
    Synthesis and deposition of extracellular matrix (ECM) within the glomerulus and interstitium characterizes renal fibrosis, but the mechanisms underlying this process are incompletely understood...
  55. ncbi Atrial fibrosis: mechanisms and clinical relevance in atrial fibrillation
    Brett Burstein
    Research Center and Department of Medicine, Montreal Heart Institute and Universite de Montreal, and Department of Pharmacology and Therapeutics, McGill University, Montreal, Quebec, Canada
    J Am Coll Cardiol 51:802-9. 2008
    ..in both clinical and experimental AF paradigms, and is an important feature of the AF substrate, producing fibrosis that alters atrial tissue composition and function...
  56. pmc Myocardial extravascular extracellular volume fraction measurement by gadolinium cardiovascular magnetic resonance in humans: slow infusion versus bolus
    Erik B Schelbert
    Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    J Cardiovasc Magn Reson 13:16. 2011
    Myocardial extravascular extracellular volume fraction (Ve) measures quantify diffuse fibrosis not readily detectable by conventional late gadolinium (Gd) enhancement (LGE)...
  57. pmc Noninvasive evaluation of kidney hypoxia and fibrosis using magnetic resonance imaging
    Tsutomu Inoue
    Department of Nephrology, Faculty of Medicine, Saitama Medical University, Saitama, Japan
    J Am Soc Nephrol 22:1429-34. 2011
    Interstitial fibrosis and hypoxia accelerate the progression of CKD, but clinical tools to quantitate these factors in patients are lacking...
  58. ncbi Serum-glucocorticoid regulated kinase 1 regulates alternatively activated macrophage polarization contributing to angiotensin II-induced inflammation and cardiac fibrosis
    Min Yang
    Beijing Anzhen Hospital affiliated to the Capital Medical University, China
    Arterioscler Thromb Vasc Biol 32:1675-86. 2012
    ..Macrophage recruitment and polarization contribute to the development of cardiac fibrosis. Although serum-glucocorticoid regulated kinase 1 (SGK1) is a key mediator of fibrosis, its role in regulating ..
  59. ncbi Fibroblasts derive from hepatocytes in liver fibrosis via epithelial to mesenchymal transition
    Michael Zeisberg
    Division of Matrix Biology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachussetts 02215, USA
    J Biol Chem 282:23337-47. 2007
    Activated fibroblasts are key contributors to the fibrotic extracellular matrix accumulation during liver fibrosis. The origin of such fibroblasts is still debated, although several studies point to stellate cells as the principal source...
  60. pmc Cardiac fibrosis and dysfunction in experimental diabetic cardiomyopathy are ameliorated by alpha-lipoic acid
    Chun jun Li
    Key Laboratory of Hormone and Development Ministry of Health, Metabolic Disease Hospital and Tianjin Institute of Endocrinology, Tianjin Medical University, Tianjin, China
    Cardiovasc Diabetol 11:73. 2012
    ..In this study, we have investigated the effects of ALA on cardiac dysfunction, mitochondrial oxidative stress (MOS), extracellular matrix (ECM) remodeling and interrelated signaling pathways in a diabetic rat model...
  61. pmc Human corneal fibrosis: an in vitro model
    Dimitris Karamichos
    Department of Ophthalmology, Harvard Medical School, Schepens Eye Research Institute, Boston, Massachusetts 02114, USA
    Invest Ophthalmol Vis Sci 51:1382-8. 2010
    Corneal injury may ultimately lead to a scar by way of corneal fibrosis, which is characterized by the presence of myofibroblasts and improper deposition of extracellular matrix (ECM) components...
  62. pmc Fibroblasts and myofibroblasts in renal fibrosis
    Soma Meran
    Institute of Nephrology, School of Medicine, University of Cardiff, Heath Park, UK
    Int J Exp Pathol 92:158-67. 2011
    Interstitial fibrosis, associated with extensive accumulation of extracellular matrix constituents in the cortical interstitium, is directly correlated to progression of renal disease...
  63. ncbi Schistosomiasis and liver fibrosis
    Z A Andrade
    Laboratory of Experimental Pathology, Gonçalo Moniz Research Center FIOCRUZ Salvador, BA, Brazil
    Parasite Immunol 31:656-63. 2009
    Schistosoma mansoni infection invariably results in liver fibrosis of the host...
  64. pmc Integrin-TGF-beta crosstalk in fibrosis, cancer and wound healing
    Coert Margadant
    Division of Cell Biology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
    EMBO Rep 11:97-105. 2010
    ..physiology, as well as in a variety of pathological processes including systemic sclerosis, idiopathic pulmonary fibrosis, chronic obstructive pulmonary disease and cancer; thus, integrins could provide attractive therapeutic targets ..
  65. pmc Activation of canonical Wnt signalling is required for TGF-β-mediated fibrosis
    Alfiya Akhmetshina
    Department of Internal Medicine 3 and Institute for Clinical Immunology, University of Erlangen Nuremberg, 91054 Erlangen, Germany
    Nat Commun 3:735. 2012
    ..Activation of the canonical Wnt pathway stimulates fibroblasts in vitro and induces fibrosis in vivo...
  66. pmc Hypoxia-inducible factor 1alpha induces fibrosis and insulin resistance in white adipose tissue
    Nils Halberg
    Touchstone Diabetes Center, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Mol Cell Biol 29:4467-83. 2009
    ..In contrast, we observed that HIF1alpha initiates adipose tissue fibrosis, with an associated increase in local inflammation...
  67. pmc The extracellular matrix: an active or passive player in fibrosis?
    Thomas N Wight
    Hope Heart Matrix Biology Program, Benaroya Research Institute, 1201 Ninth Ave, Seattle, WA 98101, USA
    Am J Physiol Gastrointest Liver Physiol 301:G950-5. 2011
    b>Fibrosis is characterized by excessive accumulation of collagen and other extracellular matrix (ECM) components, and this process has been likened to aberrant wound healing...
  68. pmc T1 mapping of the gadolinium-enhanced myocardium: adjustment for factors affecting interpatient comparison
    Neville Gai
    Radiology and Imaging Sciences, Clinical Center, and National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, Maryland 20892, USA
    Magn Reson Med 65:1407-15. 2011
    ..gadolinium-enhanced cardiac magnetic resonance imaging has shown promise in identifying diffuse myocardial fibrosis. Despite careful control of magnetic resonance imaging parameters, comparison of T(1) times between different ..
  69. pmc Inhibiting microRNA-192 ameliorates renal fibrosis in diabetic nephropathy
    Sumanth Putta
    Department of Diabetes, Division of Molecular Diabetes Research, Beckman Research Institute of the City of Hope, Duarte, CA 91010, USA
    J Am Soc Nephrol 23:458-69. 2012
    ..of collagen, TGF-β, and fibronectin; immunostaining confirmed the downregulation of these mediators of renal fibrosis. Furthermore, LNA-anti-miR-192 attenuated proteinuria in these diabetic mice...
  70. pmc Inflammation and fibrosis during Chlamydia pneumoniae infection is regulated by IL-1 and the NLRP3/ASC inflammasome
    Xianbao He
    Section of Infectious Diseases, Department of Medicine, Boston Medical Center, Boston University School of Medicine, Boston, MA 02118, USA
    J Immunol 184:5743-54. 2010
    ..was lower, whereas there was evidence of increased infiltrating fibroblasts and mesenchymal cells and more lung fibrosis. We conclude that C...
  71. pmc Epithelial-mesenchymal transition (EMT) in kidney fibrosis: fact or fantasy?
    Wilhelm Kriz
    Department of Anatomy and Developmental Biology, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany
    J Clin Invest 121:468-74. 2011
    ..by which injured renal tubular cells transform into mesenchymal cells that contribute to the development of fibrosis in chronic renal failure...
  72. pmc Klotho inhibits transforming growth factor-beta1 (TGF-beta1) signaling and suppresses renal fibrosis and cancer metastasis in mice
    Shigehiro Doi
    Department of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    J Biol Chem 286:8655-65. 2011
    b>Fibrosis is a pathological process characterized by infiltration and proliferation of mesenchymal cells in interstitial space...
  73. pmc PAI-1 in tissue fibrosis
    Asish K Ghosh
    Feinberg Cardiovascular Research Institute, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    J Cell Physiol 227:493-507. 2012
    b>Fibrosis is defined as a fibroproliferative or abnormal fibroblast activation-related disease...
  74. ncbi The role of EMT in renal fibrosis
    Rosemarie M Carew
    Danielle Alberti Memorial Centre for Diabetes Complications, Vascular Division, Baker Heart and Diabetes Institute, Melbourne, Australia 3004
    Cell Tissue Res 347:103-16. 2012
    ..transition (EMT) plays a pivotal role in embryonic development, wound healing, tissue regeneration, organ fibrosis and cancer progression...
  75. pmc Osteopontin promotes fibrosis in dystrophic mouse muscle by modulating immune cell subsets and intramuscular TGF-beta
    Sylvia A Vetrone
    Department of Neurology, David Geffen School of Medicine, UCLA, Los Angeles, California 90095 7334, USA
    J Clin Invest 119:1583-94. 2009
    ..in CD4+ and FoxP3+ Tregs was also observed in DMM muscle, which also showed reduced levels of TGF-beta, a known fibrosis mediator...
  76. pmc Pericytes and perivascular fibroblasts are the primary source of collagen-producing cells in obstructive fibrosis of the kidney
    Shuei Liong Lin
    Laboratory of Inflammation Research, Renal Division, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Am J Pathol 173:1617-27. 2008
    Understanding the origin of scar-producing myofibroblasts is vital in discerning the mechanisms by which fibrosis develops in response to inflammatory injury...
  77. ncbi Periostin induces proliferation of differentiated cardiomyocytes and promotes cardiac repair
    Bernhard Kuhn
    Department of Cardiology, Children s Hospital Boston, 300 Longwood Avenue, Boston, Massachusetts 02115, USA
    Nat Med 13:962-9. 2007
    ..reentry and mitosis were associated with improved ventricular remodeling and myocardial function, reduced fibrosis and infarct size, and increased angiogenesis...
  78. ncbi Prognostic significance of myocardial fibrosis in hypertrophic cardiomyopathy
    Rory O'Hanlon
    Department of Cardiovascular Magnetic Resonance, Royal Brompton and Harefield NHS Foundation Trust, London, UK
    J Am Coll Cardiol 56:867-74. 2010
    We investigated the significance of fibrosis detected by late gadolinium enhancement cardiovascular magnetic resonance for the prediction of major clinical events in hypertrophic cardiomyopathy (HCM).
  79. pmc Hedgehog signaling regulates epithelial-mesenchymal transition during biliary fibrosis in rodents and humans
    Alessia Omenetti
    Division of Gastroenterology, Department of Medicine, Duke University Medical Center, and Institute for Genome Sciences and Policy, Duke University, Durham, North Carolina, USA
    J Clin Invest 118:3331-42. 2008
    ..cholangiocytes isolated from rats that had undergone bile duct ligation (BDL), an experimental model of biliary fibrosis, EMT was localized to cholangiocytes with Hh pathway activity...
  80. pmc Dissection of key events in tubular epithelial to myofibroblast transition and its implications in renal interstitial fibrosis
    J Yang
    Department of Pathology, Division of Cellular and Molecular Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    Am J Pathol 159:1465-75. 2001
    ..These alterations in epithelial phenotypes in vitro were essentially recapitulated in a mouse model of renal fibrosis induced by unilateral ureteral obstruction...
  81. ncbi Angiotensin-converting enzyme 2 suppresses pathological hypertrophy, myocardial fibrosis, and cardiac dysfunction
    Jiuchang Zhong
    Division of Cardiology, Department of Medicine, Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, Alberta, T6G 2S2, Canada
    Circulation 122:717-28, 18 p following 728. 2010
    ..We hypothesized that ACE2 is a negative regulator of angiotensin II (Ang II)-mediated signaling and its adverse effects on the cardiovascular system...
  82. ncbi Antifibrotic properties of c-Ski and its regulation of cardiac myofibroblast phenotype and contractility
    Ryan H Cunnington
    Department of Physiology, Institute of Cardiovascular Sciences, University of Manitoba, Winnipeg, Canada
    Am J Physiol Cell Physiol 300:C176-86. 2011
    ..Finally, we observed a significant increase in 105-kDa c-Ski in the cytosolic fraction of cells of the infarct scar and adjacent remnant myocardium vs. noninfarcted controls...
  83. pmc miR-200b precursor can ameliorate renal tubulointerstitial fibrosis
    Shigeyoshi Oba
    Department of Nephrology and Endocrinology, University of Tokyo School of Medicine, Tokyo, Japan
    PLoS ONE 5:e13614. 2010
    ..Unilateral ureter obstruction (UUO) is a common model of EMT of tubular cells and subsequent tubulointerstitial fibrosis. In order to examine the role of miR-200 family members in tubulointerstitial fibrosis, their expression was ..
  84. ncbi Fibrosis and adipogenesis originate from a common mesenchymal progenitor in skeletal muscle
    Akiyoshi Uezumi
    Division for Therapies against Intractable Diseases, Institute for Comprehensive Medical Science, Fujita Health University, Kutsukake cho, Toyoake, Aichi 470 1192, Japan
    J Cell Sci 124:3654-64. 2011
    Accumulation of adipocytes and collagen type-I-producing cells (fibrosis) is observed in muscular dystrophies...
  85. pmc T1 mapping of the myocardium: intra-individual assessment of the effect of field strength, cardiac cycle and variation by myocardial region
    Nadine Kawel
    Radiology and Imaging Sciences and Molecular Biomedical Imaging Laboratory, National Institute of Biomedical Imaging and Bioengineering, Bethesda, MD, USA
    J Cardiovasc Magn Reson 14:27. 2012
    ..T1 relaxation time (T1 time) and extracellular volume fraction (ECV) are altered in the presence of myocardial fibrosis. The purpose of this study was to evaluate acquisition factors that may result in variation of measured T1 time ..
  86. pmc Rapamycin ameliorates PKD resulting from conditional inactivation of Pkd1
    Jonathan M Shillingford
    Department of Molecular, Cellular, and Developmental Biology, University of California Santa Barbara, Santa Barbara, CA 93106 9610, USA
    J Am Soc Nephrol 21:489-97. 2010
    ..features of human PKD including aberrant mTOR activation, epithelial proliferation and apoptosis, and progressive fibrosis. Treatment with rapamycin was highly effective: It reduced cyst growth, preserved renal function, inhibited ..
  87. pmc Macrophages and immunologic inflammation of the kidney
    Jeremy S Duffield
    Laboratory of Inflammation Research, Renal Division, Department of Medicine, Brigham and Women s Hospital, Boston, MA, USA
    Semin Nephrol 30:234-54. 2010
    ..This article advances the case that targeting macrophage activation and phenotype is leading to new therapies in the treatment of many acute and chronic kidney diseases...
  88. pmc Exogenously administered secreted frizzled related protein 2 (Sfrp2) reduces fibrosis and improves cardiac function in a rat model of myocardial infarction
    Wei He
    Mandel Center for Hypertension Research and Division of Cardiovascular Medicine, Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Proc Natl Acad Sci U S A 107:21110-5. 2010
    ..As early as 2 wk after injection, Sfrp2 significantly reduced left ventricular (LV) fibrosis as shown by trichrome staining...
  89. pmc Short telomeres are a risk factor for idiopathic pulmonary fibrosis
    Jonathan K Alder
    Department of Oncology, School of Medicine, Johns Hopkins University, Baltimore, MD 21287, USA
    Proc Natl Acad Sci U S A 105:13051-6. 2008
    ..Idiopathic pulmonary fibrosis (IPF) is the most common of IIPs and shares with IIPs an increased incidence with age and unexplained scarring in ..
  90. pmc Endothelial-mesenchymal transition in bleomycin-induced pulmonary fibrosis
    Naozumi Hashimoto
    Department of Respiratory Medicine, Nagoya University Graduate School of Medicine, Showa Ku, Japan
    Am J Respir Cell Mol Biol 43:161-72. 2010
    The pathological hallmark lesions in idiopathic pulmonary fibrosis are the fibroblastic foci, in which fibroblasts are thought to be involved in the tissue remodeling, matrix deposition, and cross-talk with alveolar epithelium...
  91. ncbi Mesenchymal stem cells attenuate renal fibrosis through immune modulation and remodeling properties in a rat remnant kidney model
    Patricia Semedo
    Nephrology Division, Medicine Department, Federal University of Sao Paulo, 05508 900 Sao Paulo, SP, Brazil
    Stem Cells 27:3063-73. 2009
    ..More specifically, it is not known whether MSCs halt fibrosis. The purpose of this work was to investigate the role of MSCs in fibrogenesis using a model of chronic renal ..
  92. pmc NF-κB in the liver--linking injury, fibrosis and hepatocellular carcinoma
    Tom Luedde
    Department of Internal Medicine III, University Hospital Rheinisch Westfälische Technische Hochschule RWTH Aachen, Pauwelsstrase 30, Aachen, Germany
    Nat Rev Gastroenterol Hepatol 8:108-18. 2011
    ..triggers inflammatory and wound-healing responses that in the long run promote the development of hepatic fibrosis and HCC...
  93. pmc Cardiac fibrosis in mice with hypertrophic cardiomyopathy is mediated by non-myocyte proliferation and requires Tgf-β
    Polakit Teekakirikul
    Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Clin Invest 120:3520-9. 2010
    ..protein genes can cause hypertrophic cardiomyopathy (HCM), a disorder characterized by myocyte enlargement, fibrosis, and impaired ventricular relaxation...
  94. ncbi Prevention of angiotensin II-mediated renal oxidative stress, inflammation, and fibrosis by angiotensin-converting enzyme 2
    Jiuchang Zhong
    Division of Cardiology, Department of Medicine, Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, Alberta, Canada
    Hypertension 57:314-22. 2011
    ..These changes were associated with increased expression of fibrosis-associated genes (α-smooth muscle actin, transforming growth factor-β, procollagen type Iα1) and increased ..
  95. pmc Bone marrow-derived progenitor cells in pulmonary fibrosis
    Naozumi Hashimoto
    Department of Pathology, University of Michigan, Ann Arbor, Michigan 48109, USA
    J Clin Invest 113:243-52. 2004
    The origin of fibroblasts in pulmonary fibrosis is assumed to be intrapulmonary, but their extrapulmonary origin and especially derivation from bone marrow (BM) progenitor cells has not been ruled out...
  96. pmc Myocardial fibrosis as an early manifestation of hypertrophic cardiomyopathy
    Carolyn Y Ho
    Cardiovascular Division, Brigham and Women s Hospital, Boston, MA 02115, USA
    N Engl J Med 363:552-63. 2010
    Myocardial fibrosis is a hallmark of hypertrophic cardiomyopathy and a proposed substrate for arrhythmias and heart failure. In animal models, profibrotic genetic pathways are activated early, before hypertrophic remodeling...
  97. pmc Induction of heme oxygenase-1 can halt and even reverse renal tubule-interstitial fibrosis
    Matheus Corrêa-Costa
    Laboratory of Clinical and Experimental Immunology, Nephrology Division, Federal University of Sao Paulo UNIFESP, Sao Paulo, Brazil
    PLoS ONE 5:e14298. 2010
    The tubule-interstitial fibrosis is the hallmark of progressive renal disease and is strongly associated with inflammation of this compartment...
  98. ncbi Regulation of PDGF and its receptors in fibrotic diseases
    James C Bonner
    National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Cytokine Growth Factor Rev 15:255-73. 2004
    ..This review summarizes the literature on the role of PDGF and its receptors in the development of fibrosis in a variety of organ systems, including lung, liver, kidney, and skin.
  99. ncbi Regulation and dysregulation of fibrosis in skeletal muscle
    Antonio L Serrano
    Pompeu Fabra University, Department of Experimental and Life Sciences, Cell Biology Unit, CIBERNED, Dr Aiguader 88, Barcelona, Spain
    Exp Cell Res 316:3050-8. 2010
    ..In this review, we provide an overview of how muscle responds to damage and aging, with special emphasis on the cellular effectors and the regulatory and inflammatory pathways that can shift normal muscle repair to fibrosis development.
  100. pmc Hypoxia promotes fibrogenesis in vivo via HIF-1 stimulation of epithelial-to-mesenchymal transition
    Debra F Higgins
    Department of Medicine, Renal Electrolyte and Hypertension Division, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Clin Invest 117:3810-20. 2007
    Hypoxia has been proposed as an important microenvironmental factor in the development of tissue fibrosis; however, the underlying mechanisms are not well defined...
  101. ncbi Regulation and function of connective tissue growth factor/CCN2 in tissue repair, scarring and fibrosis
    Xu Shi-Wen
    Centre for Rheumatology, Department of Medicine, Hampstead Campus, University College London, Rowland Hill Street, London NW3 2PF, UK
    Cytokine Growth Factor Rev 19:133-44. 2008
    ..is a secreted protein with major roles in angiogenesis, chondrogenesis, osteogenesis, tissue repair, cancer and fibrosis. It is a member of the CCN family of immediate-early gene products which are characterised by four discrete ..

Research Grants78

  1. Mice Humanized with Hepatocytes and iPS Cells from Patients with Metabolic Diseas
    Stephen C Strom; Fiscal Year: 2010
    ..For example mutations in the bile salt export pump (BSEP) results in severe cholestasis and fibrosis in human patients requiring whole organ transplants, yet the knockout mouse is nearly without a phenotype...
  2. Periodontal Biomaterials with BITE (Biofilm Immunity via T-cell Enhancement)
    James D Bryers; Fiscal Year: 2012
    ..Well-recognized infections involving biofilms include bacterial endocarditis, cystic fibrosis lung infections, deep wound healing, the current dental caries epidemic, periodontal disease, vaginosis, urinary ..
  3. Angiotensin Adrenergic Interactions in the Kidney
    Roland C Blantz; Fiscal Year: 2013
    ..to activation of other molecules, enzymes and cyclins/CKI important to cell proliferation and potential kidney fibrosis. We will examine the effects of NADPH oxidase inhibition with apocycnin...
  4. Development of a Nonpsychotropic Cannabinoid Agonist for the Treatment of Sclerod
    Robert B Zurier; Fiscal Year: 2012
    ..disease of unknown cause associated with early transient inflammation and vascular injury followed by progressive fibrosis affecting skin and internal organs;most frequently esophagus, kidneys, heart, and lungs (I)...
  5. Regulation of mural cells during pulmonary capillary formation
    Stephen E McGowan; Fiscal Year: 2013
    ..Restoration of the pulmonary microvasculature is also an important therapeutic goal for interstitial fibrosis and other causes of pulmonary hypertension...
  6. Investigating Mechanism of Intracellular Rotational Transport with Optical T
    Jeffrey N Anker; Fiscal Year: 2012
    ..and associated overproduction of reactive oxygen species further oxidize RNA/DNA/proteins, leading to fibrosis, mutagenesis and lung cancer...
  7. BIOSYNTHESIS OF TRACHEAL MUCOUS GLYCOPROTEINS
    Pi Wan Cheng; Fiscal Year: 2010
    Mucus hypersecretion is a hallmark of obstructive lung diseases, including chronic bronchitis, asthma, and cystic fibrosis. This condition is the result of hypertrophy and hyperplasia of mucus cells...
  8. Molecular Markers for Progression of Pulmonary Fibrosis in Systemic Sclerosis
    Shervin Assassi; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Title: Molecular Markers for Progression of Pulmonary Fibrosis in Systemic Sclerosis Candidate: Dr...
  9. DNA methylation of extracellular superoxide dismutase in pulmonary hypertension
    EVA NOZIK GRAYCK; Fiscal Year: 2012
    ..enzyme in the vessel wall, identify the role of extracellular superoxide in proliferation, inflammation and fibrosis contributing to pulmonary vascular remodeling, and provide a rationale for novel therapeutic tools to improve ..
  10. Pathobiology of Cystic Fibrosis-Related Diabetes in a Ferret Model
    Zoe Stewart; Fiscal Year: 2013
    ..John Engelhardt, a national authority on the molecular pathophysiology of cystic fibrosis (CF) and strategies to utilize recombinant adenovirus-associated viruses (rAAV) as gene therapy vectors. Dr...
  11. Controlling Radiation Injury by TLR5 Agonists
    Andrei V Gudkov; Fiscal Year: 2012
    ..The frequency and severity of fibrosis and cancer development will be assessed in a mouse model...
  12. Alternative Macrophage Activation Limits Immunopathology
    DEBROSKI R HERBERT; Fiscal Year: 2011
    ..metabolize L-arginine into polyamines and proline, implicating AAMF as regulators of cellular proliferation and fibrosis during the wound healing response and effector cells of T helper type 2 (TH2) immunity...
  13. The Kallikrein/Kinin-Mast Cell Interaction in Volume Overload
    CHIH CHANG KEVIN WEI; Fiscal Year: 2013
    ..BK through activation of the kallikrein/kinin system and BK2 receptor prevents fibrosis and decreases blood pressure in cardiovascular and renal disease (3)...
  14. Regulation of Airway Mucin Gene Expression by Epigenetic Mechanism
    Reen Wu; Fiscal Year: 2013
    ..overproduction is one of major clinical symptoms associated with various lung diseases, such as asthma, cystic fibrosis, bronchitis, chronic obstructive pulmonary diseases, etc...
  15. Molecular mechanisms of lung disease in ataxia telangiectasia
    JoAnn M Sekiguchi; Fiscal Year: 2013
    ..and characterize a mouse model of A-T ILD using well-established and characterized methods to induce pulmonary fibrosis in animals. We have generated a conditionally inactivatable allele of ATM that can be deleted in specific tissues...
  16. Gene Therapy with Cardiotropic Vectors for the Treatment of Heart Failure
    Roger J Hajjar; Fiscal Year: 2013
    ..diabetes, infection, or inflammation results in a heterogeneous myocardium consisting of a mixture of replacement fibrosis, dysfunctional and normal myocytes...
  17. Remote-control mouse-implantable micropumps for establishment of regenerative cap
    JUAN GABRIEL contact SANTIAGO; Fiscal Year: 2010
    ..adult mammals, muscle stem cells (MuSCs) proliferate less, there is less new muscle produced, and there is more fibrosis, than in young mammals...
  18. Unbiased genome-wide screen to identify genes regulating mucous cell hyperplasia
    Jeffrey A Whitsett; Fiscal Year: 2010
    ..and function accompany and contribute to the pathogenesis of common pulmonary diseases, including asthma, cystic fibrosis (CF), and chronic obstructive pulmonary disease (COPD)...
  19. An Aldosterone-Endothelin Feedback Mechanism on Sodium Homeostasis
    Charles S Wingo; Fiscal Year: 2012
    ..Both hormones play a role in the pathogenesis of hypertension, cardiovascular fibrosis, and nephrosclerosis...
  20. Dietary Lipids and Silica-Accelerated Autoimmunity
    James J Pestka; Fiscal Year: 2013
    ..Finally, it is expected that these studies will reveal additional potential benefits of n-3 PUFA consumption on silica-induced lung disease and fibrosis, another understudied area.
  21. A Bifunctional Katp Channel Activator and Redox Mimetic for BPD
    Kanneganti Murthy; Fiscal Year: 2013
    ..by an intraperitoneal (IP) route for 3 weeks, a period characterized in this model system by progressive lung fibrosis, pulmonary arterial hypertension (PAH), and hypoalveolarization...
  22. Role of Glutathione S-Transferase P in Heart Failure
    Sumanth D Prabhu; Fiscal Year: 2013
    ..We will evaluate apoptosis, fibrosis, and inflammation together with glutathione levels, protein-adducted aldehydes, and JNK activation in the heart...
  23. Novel Macrolide Th17 Inhibitors
    Jay K Kolls; Fiscal Year: 2012
    ..their cytokine products, IL-17A and IL-17F have been implicated in chronic inflammatory diseases including cystic fibrosis, COPD and steroid resistant asthma...
  24. Functional characters of non-coding RNAs in alcoholic liver injury
    Fanyin Meng; Fiscal Year: 2013
    ..Project Summary Alcoholic liver diseases (ALD) -- ranging from alcoholic fatty liver to alcohol-induced liver fibrosis and cirrhosis - - account for more than 50% of all chronic liver diseases in western countries and are ..
  25. New therapeutics for the treatment of Acinetobactor baumannii infections.
    ALLEN BERNARD REITZ; Fiscal Year: 2013
    ..In addition, A. baumannii biofilms have been implicated in cystic fibrosis, periodontitis and urinary tract infections, due to the bacteria's ability to colonize indwelling medical ..
  26. A Novel Thioredoxin Mimetic Prodrug for Prevention of Bronchopulmonary Dysplasia
    Prakash Jagtap; Fiscal Year: 2013
    ..administered over a broad dose range for 3 weeks, a period characterized in this model system by progressive lung fibrosis, pulmonary arterial hypertension (PAH), and hypoalveolarization...
  27. Novel Means to Establish Free Radical Balance in the Neonatal Premature Lung
    Prakash Jagtap; Fiscal Year: 2011
    ..qualifies for a diagnosis of bronchopulmonary dysplasia (BPD), a disease of hypoalveolarization, interstitial fibrosis, and chronic pulmonary insufficiency...
  28. Identifying all Meckel-like ciliopathy genes by established total exome capture a
    Friedhelm Hildebrandt; Fiscal Year: 2010
    ..Retinal-renal ciliopathies cause kidney failure, retinal degeneration, liver fibrosis, mental retardation and malformations of brain, bone and heart...
  29. Transplacental Arsenic Induced Hepatic Dysfunction and Vascular Disease
    J Christopher States; Fiscal Year: 2010
    ..of changes in vascular reactivity and characterizing the nature of arterial lesions (lesion cellularity, fibrosis and inflammation) in arsenic exposed mice;2) explore transplacental arsenic-induced hepatic changes by ..
  30. A novel telomerase expressing lung fibroblast phenotype
    Sem H Phan; Fiscal Year: 2012
    ..Induction of telomerase has been observed in animal models of lung injury and fibrosis, and recent evidence points to a potential role for telomerase in certain types of pulmonary fibrosis in humans ..
  31. Role of Platelet derived growth factor receptor-a in Liver Patho-biology
    SATDARSHAN SINGH MONGA; Fiscal Year: 2013
    ..S.A. with around 5.5 million Americans suffering from hepatic fibrosis and cirrhosis...
  32. Extracellular ubiquitin: role in myocyte apoptosis and myocardial remodeling
    Krishna Singh; Fiscal Year: 2010
    ..ubiquitin inhibited ?AR-stimulated left ventricular dysfunction, cardiac myocyte apoptosis and myocardial fibrosis in mice...
  33. Needle-Implantable, Wireless Multi-Sensor for Continuous Glucose Monitoring
    Santhisagar Vaddiraju; Fiscal Year: 2010
    ..The localized release of various tissue response modifiers has also afforded effective inflammation control and fibrosis suppression along with neo-angiogenesis...
  34. Dependency of O-3 Induced Lung Mucus Hypersecretion on NQ01
    W Michael Foster; Fiscal Year: 2010
    ..For patients with asthma, chronic obstructive pulmonary disease (COPD), and cystic fibrosis, mucus hypersecretion is now being considered as a risk factor for increased morbidity...
  35. SARS-CoV Pathogenic Mechanisms in Senescent Mice
    Ralph S Baric; Fiscal Year: 2012
    ..SARS-CoV infection in young and senescent mice, determining if chronic disease manifestations of pulmonary fibrosis occur in survivors...
  36. IGFBP-5 and Hsp70 in Extracellular Matrix Homeostasis and Fibrosis
    Kristen L Veraldi; Fiscal Year: 2013
    ..Interstitial lung disease (ILD) comprises a group of more than 130 disorders characterized by scarring, or fibrosis, of the lungs...
  37. The Postischemia Inflammatory Syndrome in the Aged Kidney
    KATHERINE JULIA KELLY; Fiscal Year: 2013
    ..kidney by activating proinflammatory pathways in tubular epithelia ultimately resulting in apoptotic cell death, fibrosis and renal failure...
  38. Maternal Autoantibodies: Pathogenesis of Neonatal Lupus
    JILL PAMELA BUYON; Fiscal Year: 2013
    ..exceptional opportunity to examine the effector arm of immunity and define the mechanism whereby an Ab mediates fibrosis, which is particularly aberrant in fetal wounding...
  39. WIDEBAND CLINICAL DIAGNOSIS AND MONITORING OF MIDDLE-EAR AND COCHLEAR FUNCTION
    Douglas H Keefe; Fiscal Year: 2013
    ..the extended bandwidth of the CEOAE at least out to 10 kHz is well suited to detect early hearing loss in cystic fibrosis patients receiving ototoxic medications...
  40. Androgen Receptor Pathway and Risk of Hepatic Fibrosis in Hepatitis C
    DONNA LORRAINE WHITE; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Cirrhosis or highly advanced fibrosis is the 13th leading cause of death in the U.S. The leading cause of cirrhosis is the hepatitis C virus infection which affects more than 4 million Americans...
  41. Anti-Fibrotic Therapy for Scleroderma/SSc
    Latha Paka; Fiscal Year: 2010
    ..as systemic sclerosis-SSc) is an autoimmune disorder characterized primarily by progressive dermal and vascular fibrosis. Other organs are affected too, including lung, heart, esophagus, intestine, and kidney...
  42. Mechanism of Irradiation Pulmonary Fibrosis
    Joel S Greenberger; Fiscal Year: 2012
    ..The C57BL/6J mouse model of irradiation-induced late organizing alveolitis/fibrosis closely follows the parameters of human pulmonary irradiation damage...
  43. Lipid Transport, Bile Acid Synthesis, and Cholesterol Homeostasis
    William M Pandak; Fiscal Year: 2013
    ..A fraction of patients with NAFLD progress to liver cell necrosis, inflammation, and progressive fibrosis. NAFLD is a now recognized as a leading cause of cirrhosis in the U.S...
  44. Non-Alcoholic Fatty Liver Disease and Obstructive Sleep Apnea: Mechanistic Links
    SHIKHA SEKSARIA SUNDARAM; Fiscal Year: 2013
    ..chronic pediatric liver disease and may progress to an aggressive necro-inflammatory disease (NASH) that leads to fibrosis and cirrhosis in up to 1/3 of affected individuals...
  45. Innate Immunity and Cardiovascular Function
    Gregory L Stahl; Fiscal Year: 2013
    ..e., left ventricular dysfunction, hypertrophy and cardiac fibrosis)...
  46. Fate of Lung Stem Cells During Pulmonary Disease
    Susan M Majka; Fiscal Year: 2012
    ..PUBLIC HEALTH RELEVANCE: Pulmonary hypertension, chronic obstructive pulmonary disease, interstitial pulmonary fibrosis and other adult lung conditions are a major cause of morbidity and mortality...
  47. Inhibitors of isoprenoid synthesis for antibacterial therapy
    Donald T Moir; Fiscal Year: 2013
    ..g., HIV and cancer), cystic fibrosis patients, and those on mechanical ventilation or with burn wounds...
  48. Detection of Liver Fibrosis Using IVIM Diffusion and DCE MRI in HCV
    Bachir Taouli; Fiscal Year: 2013
    ..HCV) in the Unites States within the next years, with subsequent increased risks of liver damage, including fibrosis and cirrhosis, which may eventually lead to hepatocellular carcinoma and end-stage liver disease requiring liver ..
  49. Liver disease in CF: CFTR controls innate immunity in biliary epithelium
    Mario Strazzabosco; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Cystic Fibrosis (CF) is a common and clinically severe genetic disease, caused by mutations in CFTR, a membrane protein that mediates Cl- and fluid secretion in a number of secretory epithelia, ..
  50. Use of Phosphodiesterase Inhibitors to Evaluate the Pathobiology of CF
    JENNIFER L TAYLOR-COUSAR; Fiscal Year: 2013
    ..and translational research that contributes to the understanding of the pathophysiology and treatment of Cystic Fibrosis (CF) lung disease...
  51. Iowa Phase II Clinical Trials of Novel Therapies for Lung Diseases (U01
    Lakshmi Durairaj; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Cystic fibrosis (CF) is characterized by chronic bacterial airway infection with progressive destruction which contributes to 95% of the mortality from this disease...
  52. Mechanisms and Enviromental Determinants of Rhinovirus Illness Severity
    James E Gern; Fiscal Year: 2013
    ..bronchiolitis, influenza-like illness, and exacerbations of chronic lung diseases such as asthma, cystic fibrosis, and chronic obstructive lung disease (COPD)...
  53. A rational approach to liver toxicity monitoring in methotrexate users
    Gabriela Schmajuk; Fiscal Year: 2013
    ..testing of liver function tests (LFTs) every 12 weeks with the intent of reducing the incidence of hepatic fibrosis and cirrhosis...
  54. Mechanisms of Airway Smooth Muscle Hypertrophy
    Marc B Hershenson; Fiscal Year: 2013
    ..BPD phenotype;(ii) SPARC and periostin are required for hyperoxia-induced hypoalveolarization and interstitial fibrosis;iii) mesenchyme-specific inhibition of GSK-3[unreadable] is sufficient for the BPD phenotype;and iv) ..
  55. ROLE OF SAMe IN LIVER FUNCTION AND INJURY
    SHELLY CHI LOO LU; Fiscal Year: 2012
    ..GNMT) KO mice and patients with GNMT mutations, can lead to steatohepatitis, increased hepatocyte apoptosis, fibrosis, and HCC...
  56. TNF Family Members and Control of Fibrotic Disease
    Michael Croft; Fiscal Year: 2013
    ..If this fibrosis is extensive it can prevent normal organ function...
  57. SCHISTOSOME EGG INDUCED TH2 RESPONSES
    Edward J Pearce; Fiscal Year: 2013
    ..the sicker it will be), and over time the repeated cycles of inflammation and resolution can lead to severe liver fibrosis, which again mirrors the most serious disease manifestation of human schistosomiasis...
  58. High-affinity RNA targets of Survival Motor Neuron Protein
    Ravindra N Singh; Fiscal Year: 2013
    ..the frequency of occurrence, SMA is ranked as the second leading genetic cause of infant mortality after cystic fibrosis. Most cases of SMA are associated with the low levels of SMN protein due to deletion or mutation of Survival ..
  59. MOUSE MODEL FOR DISEASES OF PROTEIN MISFOLDING
    P Michael Conn; Fiscal Year: 2012
    ..Diseases caused by misfolding (which may benefit from this approach) include cystic fibrosis, hypogonadotropic hypogonadism, nephrogenic diabetes insipidus, retinitis pigmentosa, hypercholesterolemia, ..
  60. UT GASTROENTEROLOGY / HEPATOLOGY RESEARCH TRAINING PROGRAM
    Ezra Burstein; Fiscal Year: 2013
    ..steatosis, lipid metabolism and gallstone disease;immune responses in the liver and acute liver failure;hepatic fibrosis and portal hypertension;and, viral hepatitis and anti-viral immunity...
  61. Safety and PK Study in Hepatic Impairment Patients
    Weizhong Cai; Fiscal Year: 2010
    Liver fibrosis, a disease affecting tens of millions of patients worldwide, is the liver scarring response to chronic injury from viral hepatitis B or C, excessive alcohol use, iron overload or extrahepatic obstructions and can progress ..
  62. Role of microRNA-122 in hepatocarcinogenesis using conditional knock out mice
    Kalpana Ghoshal; Fiscal Year: 2013
    ..mice to CDAA diet will be examined by comparing liver damage (apoptosis, steatosis or fatty liver, inflammation, fibrosis) and liver tumors (formation of adenomas and carcinomas) between these mice, and 1b) the involvement of miR-122 ..
  63. Lung Toxicity of Carbon Nanotubes in Models of Pre-Existing Respiratory Disease
    JAMES CHRISTOPHER BONNER; Fiscal Year: 2010
    ..medicine), but have properties similar to asbestos, a fiber that is linked with the development of pulmonary fibrosis (tissue scarring) and mesothelioma (a rare cancer on the pleural surface of the lung)...
  64. Comparative Effectiveness of Advanced Diagnostic Imaging for Hepatic Fibrosis
    Jayant A Talwalkar; Fiscal Year: 2010
    ..The major process responsible for this burden of disease is progressive hepatic fibrosis, which traditionally has been diagnosed by liver biopsy...
  65. FIBROSIS IN CROHNS DISEASE--ROLE OF IGF I
    ELLEN ZIMMERMANN; Fiscal Year: 1999
    Little is known about the development of fibrosis associated with chronic intestinal inflammation...
  66. CTRIP: Molecular phenotypes of rapidly progressive idiopathic pulmonary fibrosis
    Galen B Toews; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Molecular Markers of Idiopathic Pulmonary Fibrosis Progression. 2...
  67. Sodium Transport Inhibitors for Hypertension and Cystic Fibrosis
    Erik Schwiebert; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Sodium Transport Inhibitors for Hypertension and Cystic Fibrosis Scientific Summary Description Hypertension is a confounding multifactorial disorder that affects millions of patients worldwide...
  68. Selenium, Glutathione Peroxidase-1, and Homocysteine-induced Cardiac Remodeling
    Jacob Joseph; Fiscal Year: 2009
    ..Data from our laboratory demonstrate that Hhe leads to myocardial fibrosis and diastolic dysfunction...
  69. A Therapeutic Agent for Radiation-induced Lung Fibrosis
    SHUAN HUANG; Fiscal Year: 2009
    Lung fibrosis, a group of incurable lung diseases with high mortality rates, is characterized by inflammatory cell infiltration, fibroblast proliferation, and excessive deposition of extracellular matrix proteins (ECM) in lung parenchyma...
  70. PROTEOMICS AND HEPATITIS C: FIBROSIS AND PROGNOSIS
    Glenn Gourley; Fiscal Year: 2005
    Liver fibrosis is an important factor in the progression of disease for millions of people with chronic hepatitis C...
  71. Caveolins in the Pathogenesis of Idiopathic Pulmonary Fibrosis
    Dan N Predescu; Fiscal Year: 2010
    ..work are to find out what new pathogenic mechanisms are involved in initiation and progression of idiopathic lung fibrosis (IPF) with the intention to discover new molecular targets that can be used as therapeutic tools...
  72. CFFONE: A Cell Phone Support Program for Teens with Cystic Fibrosis
    Kevin Dawkins; Fiscal Year: 2007
    unreadable] DESCRIPTION (provided by applicant): Generations of patients with cystic fibrosis (CF) have spent their childhoods fighting for breath and losing...
  73. Non-invasive Ultrasound Elasticity Imaging (UEI) in Crohn's Disease
    Jonathan M Rubin; Fiscal Year: 2010
    ..in Crohn's disease, there are no imaging tools to identify which patients have significant intestinal fibrosis. Healing between flares of inflammation allows the intestine to reconstitute its epithelium, but this healing ..
  74. Novel therapeutic for Alcoholic Liver Disease
    Bert Oehlen; Fiscal Year: 2009
    ..of development: (1) mild alcoholic liver injury, (2) steatosis, (3) alcoholic hepatitis, (4) alcoholic liver fibrosis and (5) cirrhosis...
  75. MECHANISMS OF PULMONARY FIBROSIS CAUSED BY SILICA
    Gerald Davis; Fiscal Year: 2003
    ..inhaled through workplace exposure are an important world-wide cause of chronic lung disease and pulmonary fibrosis. The goal of this research is to delineate the cytokine-driven mechanisms of lung scarring caused by the ..
  76. MECHANISMS OF PULMONARY FIBROSIS
    Sem H Phan; Fiscal Year: 2010
    Pulmonary fibrosis is a common end result of diverse forms'of lung injury and interstitial lung diseases...
  77. Mechanisms of intestinal failure in post-surgical inflammatory bowel disease
    PAULINE LUND; Fiscal Year: 2009
    ..Current therapies do not effectively prevent post-surgical inflammation or fibrosis. A major goal of this research is to develop a new animal model of post- surgical inflammation and fibrosis after ..
  78. TGFB AND GENE THERAPY IN SILICA INDUCED LUNG FIBROSIS
    Patricia Sime; Fiscal Year: 2005
    ..life threatening, pulmonary inflammatory and fibrotic pathologies including acute and chronic (nodular pulmonary fibrosis) silicosis...