emphysema

Summary

Summary: A pathological accumulation of air in tissues or organs.

Top Publications

  1. pmc Role of breast regression protein-39 in the pathogenesis of cigarette smoke-induced inflammation and emphysema
    Hiroshi Matsuura
    Section of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06520 8057, USA
    Am J Respir Cell Mol Biol 44:777-86. 2011
  2. pmc Genetic ablation of Nrf2 enhances susceptibility to cigarette smoke-induced emphysema in mice
    Tirumalai Rangasamy
    Department of Environmental Health Sciences, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland 21205, USA
    J Clin Invest 114:1248-59. 2004
  3. pmc Systematic review with meta-analysis of the epidemiological evidence relating smoking to COPD, chronic bronchitis and emphysema
    Barbara A Forey
    P N Lee Statistics and Computing Ltd, Sutton, Surrey, UK
    BMC Pulm Med 11:36. 2011
  4. ncbi Transgenic expression of matrix metalloproteinase-9 causes adult-onset emphysema in mice associated with the loss of alveolar elastin
    Robert Foronjy
    Columbia University, New York, New York, USA
    Am J Physiol Lung Cell Mol Physiol 294:L1149-57. 2008
  5. pmc IL-17RA is required for CCL2 expression, macrophage recruitment, and emphysema in response to cigarette smoke
    Kong Chen
    Department of Genetics, Louisiana State University Health Science Center, New Orleans, Louisiana, United States of America
    PLoS ONE 6:e20333. 2011
  6. ncbi Endothelial cell death and decreased expression of vascular endothelial growth factor and vascular endothelial growth factor receptor 2 in emphysema
    Y Kasahara
    Division of Pulmonary Sciences and Critical Care Medicine, Pulmonary Hypertension Center, Department of Pathology, and Webb-Waring Antioxidant Research Institute, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Am J Respir Crit Care Med 163:737-44. 2001
  7. ncbi Vascular endothelial growth factor in the lung
    Norbert F Voelkel
    University of Colorado Health Sciences Center, Pulmonary and Critical Care Division, 4200 E Ninth Ave, C272, Denver, CO 80262, USA
    Am J Physiol Lung Cell Mol Physiol 290:L209-21. 2006
  8. pmc Emphysema diagnosis using X-ray dark-field imaging at a laser-driven compact synchrotron light source
    Simone Schleede
    Department of Physics and Institute of Medical Engineering, Technische Universitat Munchen, 85748 Garching, Germany
    Proc Natl Acad Sci U S A 109:17880-5. 2012
  9. ncbi Systemic soluble receptor for advanced glycation endproducts is a biomarker of emphysema and associated with AGER genetic variants in patients with chronic obstructive pulmonary disease
    Donavan T Cheng
    1 Hoffmann La Roche Inc, Nutley, New Jersey
    Am J Respir Crit Care Med 188:948-57. 2013
  10. ncbi Quantitative computed tomography: emphysema and airway wall thickness by sex, age and smoking
    T B Grydeland
    Dept of Thoracic Medicine, Haukeland University Hospital, Bergen, Norway
    Eur Respir J 34:858-65. 2009

Detail Information

Publications278 found, 100 shown here

  1. pmc Role of breast regression protein-39 in the pathogenesis of cigarette smoke-induced inflammation and emphysema
    Hiroshi Matsuura
    Section of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06520 8057, USA
    Am J Respir Cell Mol Biol 44:777-86. 2011
    ..We hypothesized that BRP-39/YKL-40 plays an important role in the pathogenesis of cigarette smoke (CS)-induced emphysema. To test this hypothesis, 10-week-old wild-type and BRP-39 null mutant mice (BRP-39(-/-)) were exposed to room ..
  2. pmc Genetic ablation of Nrf2 enhances susceptibility to cigarette smoke-induced emphysema in mice
    Tirumalai Rangasamy
    Department of Environmental Health Sciences, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland 21205, USA
    J Clin Invest 114:1248-59. 2004
    ..and protease/antiprotease imbalance have been postulated to be critical in cigarette smoke-induced (CS-induced) emphysema, oxidative stress has been suspected to play an important role in chronic obstructive pulmonary diseases...
  3. pmc Systematic review with meta-analysis of the epidemiological evidence relating smoking to COPD, chronic bronchitis and emphysema
    Barbara A Forey
    P N Lee Statistics and Computing Ltd, Sutton, Surrey, UK
    BMC Pulm Med 11:36. 2011
    Smoking is a known cause of the outcomes COPD, chronic bronchitis (CB) and emphysema, but no previous systematic review exists. We summarize evidence for various smoking indices.
  4. ncbi Transgenic expression of matrix metalloproteinase-9 causes adult-onset emphysema in mice associated with the loss of alveolar elastin
    Robert Foronjy
    Columbia University, New York, New York, USA
    Am J Physiol Lung Cell Mol Physiol 294:L1149-57. 2008
    ..the transgenic and littermate control mice over 1 yr to determine the effect of macrophage MMP-9 expression on emphysema formation and lung matrix content...
  5. pmc IL-17RA is required for CCL2 expression, macrophage recruitment, and emphysema in response to cigarette smoke
    Kong Chen
    Department of Genetics, Louisiana State University Health Science Center, New Orleans, Louisiana, United States of America
    PLoS ONE 6:e20333. 2011
    ..Remarkably, in contrast to WT mice, IL-17RA(-/-) mice failed to develop emphysema after 6 months of cigarette smoke exposure...
  6. ncbi Endothelial cell death and decreased expression of vascular endothelial growth factor and vascular endothelial growth factor receptor 2 in emphysema
    Y Kasahara
    Division of Pulmonary Sciences and Critical Care Medicine, Pulmonary Hypertension Center, Department of Pathology, and Webb-Waring Antioxidant Research Institute, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Am J Respir Crit Care Med 163:737-44. 2001
    b>Emphysema due to cigarette smoking is characterized by a loss of alveolar structures...
  7. ncbi Vascular endothelial growth factor in the lung
    Norbert F Voelkel
    University of Colorado Health Sciences Center, Pulmonary and Critical Care Division, 4200 E Ninth Ave, C272, Denver, CO 80262, USA
    Am J Physiol Lung Cell Mol Physiol 290:L209-21. 2006
    ..evidence that VEGF also plays a role in several acute and chronic lung diseases, such as acute lung injury, severe pulmonary hypertension, and emphysema. Here we provide a comprehensive overview of the rapidly expanding literature.
  8. pmc Emphysema diagnosis using X-ray dark-field imaging at a laser-driven compact synchrotron light source
    Simone Schleede
    Department of Physics and Institute of Medical Engineering, Technische Universitat Munchen, 85748 Garching, Germany
    Proc Natl Acad Sci U S A 109:17880-5. 2012
    In early stages of various pulmonary diseases, such as emphysema and fibrosis, the change in X-ray attenuation is not detectable with absorption-based radiography...
  9. ncbi Systemic soluble receptor for advanced glycation endproducts is a biomarker of emphysema and associated with AGER genetic variants in patients with chronic obstructive pulmonary disease
    Donavan T Cheng
    1 Hoffmann La Roche Inc, Nutley, New Jersey
    Am J Respir Crit Care Med 188:948-57. 2013
    b>Emphysema in chronic obstructive pulmonary disease (COPD) can be characterized by high-resolution chest computed tomography (HRCT); however, the repeated use of HRCT is limited because of concerns regarding radiation exposure and cost.
  10. ncbi Quantitative computed tomography: emphysema and airway wall thickness by sex, age and smoking
    T B Grydeland
    Dept of Thoracic Medicine, Haukeland University Hospital, Bergen, Norway
    Eur Respir J 34:858-65. 2009
    We investigated how quantitative high-resolution computed tomography (HRCT) measures of emphysema and airway wall thickness (AWT) vary with sex, age and smoking history...
  11. pmc Subclinical atherosclerosis, airflow obstruction and emphysema: the MESA Lung Study
    R G Barr
    Dept of Medicine, Columbia University Medical Center, New York, NY 10032, USA
    Eur Respir J 39:846-54. 2012
    ..The affected vascular bed and contribution of emphysema to cardiovascular risk are unclear...
  12. ncbi The presence and progression of emphysema in COPD as determined by CT scanning and biomarker expression: a prospective analysis from the ECLIPSE study
    Harvey O Coxson
    Department of Radiology, University of British Columbia, Vancouver, Canada Electronic address
    Lancet Respir Med 1:129-36. 2013
    b>Emphysema is a key contributor to airflow limitation in chronic obstructive pulmonary disease (COPD) and can be quantified using CT scanning...
  13. pmc Pulmonary function measures predict mortality differently in IPF versus combined pulmonary fibrosis and emphysema
    S L Schmidt
    Dept of Internal Medicine, Pulmonary and Critical Care Division, University of Michigan, Ann Arbor, MI, USA
    Eur Respir J 38:176-83. 2011
    ..was derived to represent the extent of fibrosis on high-resolution computed tomography (HRCT), adjusting for emphysema in patients with idiopathic pulmonary fibrosis (IPF)...
  14. pmc Relationship between quantitative CT metrics and health status and BODE in chronic obstructive pulmonary disease
    Carlos H Martinez
    Division of Pulmonary and Critical Care Medicine, University of Michigan Health System, 3916 Taubman Center, Box 5360, 1500 E Medical Center Drive, Ann Arbor, MI 48109 5360, USA
    Thorax 67:399-406. 2012
    ..The authors hypothesised that QCT-defined emphysema and airway abnormalities relate to St George's Respiratory Questionnaire (SGRQ) and Body-Mass Index, Airflow ..
  15. pmc Increased matrix metalloproteinase (MMPs) levels do not predict disease severity or progression in emphysema
    JEANINE M D'ARMIENTO
    Division of Pulmonary, Allergy and Critical Care Medicine, Columbia University Medical Center, New York, New York, United States of America
    PLoS ONE 8:e56352. 2013
    ..This study aimed to determine whether bronchoalveolar lavage (BALF) or plasma MMP measurements correlated with disease severity or functional decline in emphysema.
  16. pmc Endothelial microparticles in mild chronic obstructive pulmonary disease and emphysema. The Multi-Ethnic Study of Atherosclerosis Chronic Obstructive Pulmonary Disease study
    Michael A Thomashow
    Department of Medicine, ColumbiaUniversity, New York, NY, USA
    Am J Respir Crit Care Med 188:60-8. 2013
    ..research implicates alveolar endothelial cell apoptosis in the pathogenesis of chronic obstructive pulmonary disease (COPD) and emphysema. However, information on endothelial microparticles (EMPs) in mild COPD and emphysema is lacking.
  17. pmc Chronic obstructive pulmonary disease and altered risk of lung cancer in a population-based case-control study
    Jill Koshiol
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, United States of America
    PLoS ONE 4:e7380. 2009
    ..Chronic obstructive pulmonary disease (COPD) has been consistently associated with increased risk of lung cancer. However, previous studies have had limited ability to determine whether the association is due to smoking...
  18. ncbi Pulmonary inflammation and emphysema: role of the cytokines IL-18 and IL-13
    Tomoaki Hoshino
    Department of Internal Medicine 1, Kurume University School of Medicine, Kurume, Japan
    Am J Respir Crit Care Med 176:49-62. 2007
    ..Our results demonstrate that IL-18 overproduction in the lungs can induce lung diseases, such as pulmonary inflammation, lung fibrosis, and COPD...
  19. pmc Association of radiographic emphysema and airflow obstruction with lung cancer
    David O Wilson
    Division of Pulmonary Allergy and Critical Care Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Am J Respir Crit Care Med 178:738-44. 2008
    To study the relationship between emphysema and/or airflow obstruction and lung cancer in a high-risk population.
  20. pmc Ceramide upregulation causes pulmonary cell apoptosis and emphysema-like disease in mice
    Irina Petrache
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, Johns Hopkins University, 5501 Hopkins Bayview Circle, JHAAC, 4B 65, Baltimore, Maryland 21224, USA
    Nat Med 11:491-8. 2005
    Alveolar cell apoptosis is involved in the pathogenesis of emphysema, a prevalent disease primarily caused by cigarette smoking...
  21. ncbi Chemokines in bronchiolar epithelium in the development of chronic obstructive pulmonary disease
    Satoshi Fuke
    First Department of Medicine, Hokkaido University School of Medicine, N 15, W 7, Kita ku, Sapporo, Japan, 060 8638
    Am J Respir Cell Mol Biol 31:405-12. 2004
    ..and monocyte chemoattractant protein-1 mRNA levels higher in smokers with airflow limitation and/or emphysema than those in never-smokers or smokers without either airflow limitation or emphysema...
  22. ncbi Reproducibility of volume and densitometric measures of emphysema on repeat computed tomography with an interval of 1 week
    Daniel Chong
    Center for Computer Vision and Imaging Biomarkers, David Geffen School of Medicine, UCLA, 924 Westwood Blvd, Ste 615, Los Angeles, CA, USA
    Eur Radiol 22:287-94. 2012
    The reproducibilities of CT lung volume and densitometric measures of emphysema were assessed over 1 week. The influence of breathhold on reproducibility was assessed.
  23. pmc Deletion of vitamin D receptor leads to premature emphysema/COPD by increased matrix metalloproteinases and lymphoid aggregates formation
    Isaac K Sundar
    Department of Environmental Medicine, Lung Biology and Disease Program, University of Rochester Medical Center, Box 850, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Biochem Biophys Res Commun 406:127-33. 2011
    ..that deficiency of VDR leads to significant alterations in lung phenotype that are characteristics of COPD/emphysema associated with increased inflammatory response...
  24. ncbi Progressive adult-onset emphysema in transgenic mice expressing human MMP-1 in the lung
    Robert F Foronjy
    Department of Medicine, Division of Molecular Medicine and Pulmonary Medicine, Columbia University, New York, New York 10032, USA
    Am J Physiol Lung Cell Mol Physiol 284:L727-37. 2003
    ..human matrix metalloproteinase-1 (MMP-1) develop emphysematous changes similar to those seen in smoking-induced emphysema in humans...
  25. pmc A combined pulmonary-radiology workshop for visual evaluation of COPD: study design, chest CT findings and concordance with quantitative evaluation
    R Graham Barr
    Division of Radiology, National Jewish Health, Denver, CO 80206, USA
    COPD 9:151-9. 2012
    ....
  26. pmc Inducible targeting of IL-13 to the adult lung causes matrix metalloproteinase- and cathepsin-dependent emphysema
    T Zheng
    Section of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06520 8057, USA
    J Clin Invest 106:1081-93. 2000
    ..Here we show that IL-13, a critical cytokine in asthma, causes emphysema with enhanced lung volumes and compliance, mucus metaplasia, and inflammation, when inducibly overexpressed in ..
  27. ncbi Clinical features and outcomes in combined pulmonary fibrosis and emphysema in idiopathic pulmonary fibrosis
    Christopher J Ryerson
    Department of Medicine, University of British Columbia, Vancouver, BC, Canada
    Chest 144:234-40. 2013
    Combined pulmonary fibrosis and emphysema (CPFE) is increasingly recognized, but its prevalence and prognosis remain unclear...
  28. pmc Heterogeneity of pulmonary perfusion as a mechanistic image-based phenotype in emphysema susceptible smokers
    Sara K Alford
    Departmentsof Radiology, University of Iowa, Iowa City, IA 52242, USA
    Proc Natl Acad Sci U S A 107:7485-90. 2010
    ..dysfunction and pathology of pulmonary vascular responses may serve as a precursor to smoking-associated emphysema. Although it is known that emphysematous destruction leads to vasculature changes, less is known about early ..
  29. ncbi Pulmonary hypertension in COPD
    A Chaouat
    Dept for Respiratory Diseases and Respiratory Intensive Care, Centre Hospitalier Universitaire de Nancy, Vandoeuvre les Nancy, France
    Eur Respir J 32:1371-85. 2008
    ..and is thought to result from the combined effects of hypoxia, inflammation and loss of capillaries in severe emphysema. A small proportion of COPD patients may present with "out-of-proportion" pulmonary hypertension, defined by a ..
  30. pmc Cigarette smoke induction of osteopontin (SPP1) mediates T(H)17 inflammation in human and experimental emphysema
    Ming Shan
    Department of Medicine, Section of Pulmonary and Critical Care, Baylor College of Medicine, Houston, TX 77030, USA
    Sci Transl Med 4:117ra9. 2012
    ..We have shown that CD1a+ antigen-presenting cells (APCs) from lungs of patients with emphysema can induce autoreactive T helper 1 (T(H)1) and T(H)17 cells...
  31. ncbi Assessment of the relationship between lung parenchymal destruction and impaired pulmonary perfusion on a lobar level in patients with emphysema
    Julia Ley-Zaporozhan
    Department of Radiology, Johannes Gutenberg University, Mainz, Germany
    Eur J Radiol 63:76-83. 2007
    To assess the relationship between lung parenchymal destruction and impaired pulmonary perfusion on a lobar level using CT and MRI in patients with emphysema.
  32. ncbi Evaluation of emphysema severity and progression in a rabbit model: comparison of hyperpolarized 3He and 129Xe diffusion MRI with lung morphometry
    Jaime F Mata
    Dept of Radiology, University of Virginia School of Medicine, Charlottesville, VA 22908, USA
    J Appl Physiol 102:1273-80. 2007
    ..ADCs) of hyperpolarized (3)He and (129)Xe gases were measured in the lungs of rabbits with elastase-induced emphysema and correlated against the mean chord length from lung histology...
  33. pmc Amelioration of emphysema in mice through lentiviral transduction of long-lived pulmonary alveolar macrophages
    Andrew A Wilson
    Pulmonary Center and Department of Medicine, Boston University School of Medicine, 715 Albany Street, Boston, Massachusetts 02118, USA
    J Clin Invest 120:379-89. 2010
    ..in vivo is an attractive approach for both modulating gene expression and correcting inherited mutations such as emphysema caused by human alpha1 antitrypsin (hAAT) deficiency...
  34. ncbi MEKC of desmosine and isodesmosine in urine of chronic destructive lung disease patients
    S Viglio
    Dipartimento di Biochemical, Istituto di Ricovero e Cura a Carattere Scientifico IRCCS Policlinico San Matteo, Università degli nStudi di Pavia
    Eur Respir J 15:1039-45. 2000
    ..Results obtained in subjects with alphal-antitrypsin deficiency suggest that this method might be used to evaluate the putative efficacy of replacement therapy...
  35. ncbi Severe bilateral panlobular emphysema and pulmonary arterial hypoplasia: unusual manifestations of Menkes disease
    Dorothy K Grange
    Department of Pediatrics, Washington University School of Medicine, St Louis, Missouri, USA
    Am J Med Genet A 139:151-5. 2005
    ..We report on a patient with Menkes disease in whom severe diffuse emphysema caused respiratory failure and death at 14 months of age...
  36. pmc Role of CCR5 in IFN-gamma-induced and cigarette smoke-induced emphysema
    Bing Ma
    Section of Pulmonary and Critical Care Medicine, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Clin Invest 115:3460-72. 2005
    ..we defined the role(s) of CCR5 in the pathogenesis of IFN-gamma-induced inflammation and remodeling in a murine emphysema model...
  37. ncbi Structural emphysema does not correlate with lung compliance: lessons from the mouse smoking model
    Robert F Foronjy
    Department of Medicine, Division of Molecular Medicine and Pulmonary Medicine, Columbia University, New York, USA
    Exp Lung Res 31:547-62. 2005
    The murine smoke-induced model produces histologic emphysema. The authors sought to assess whether the structural emphysema that occurred correlated with the development of compliance changes...
  38. ncbi Apoptosis and emphysema: the missing link
    Rubin M Tuder
    Division of Cardiopulmonary Pathology, Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Am J Respir Cell Mol Biol 28:551-4. 2003
  39. ncbi Mechanisms of emphysema in alpha1-antitrypsin deficiency: molecular and cellular insights
    B Gooptu
    School of Crystallography, Institute of Structural Molecular Biology, Birkbeck College, University of London, London, UK
    Eur Respir J 34:475-88. 2009
    The severe, early onset emphysema that occurs in patients with circulating deficiency of alpha(1)-antitrypsin (alpha(1)-AT) attests to the importance of this protease inhibitor in maintaining lung parenchymal integrity...
  40. doi Common origins of lung cancer and COPD
    A McGarry Houghton
    Department of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    Nat Med 14:1023-4. 2008
  41. pmc Alveolar macrophage activation and an emphysema-like phenotype in adiponectin-deficient mice
    R Summer
    The Pulmonary Center, R 304, Boston Univ School of Medicine, 80 E Concord St, Boston, MA 02118, USA
    Am J Physiol Lung Cell Mol Physiol 294:L1035-42. 2008
    ..in lung lining fluid and that adiponectin deficiency leads to increases in proinflammatory mediators and an emphysema-like phenotype in the mouse lung...
  42. pmc Cluster analysis in severe emphysema subjects using phenotype and genotype data: an exploratory investigation
    Michael H Cho
    Channing Laboratory, Brigham and Women s Hospital, Boston, MA, USA
    Respir Res 11:30. 2010
    ..One reason may be heterogeneity in disease definition. Unsupervised learning approaches may assist in understanding disease heterogeneity...
  43. ncbi P2X7 receptor signaling in the pathogenesis of smoke-induced lung inflammation and emphysema
    Monica Lucattelli
    Department of Pulmonary Medicine, University of Freiburg, Germany
    Am J Respir Cell Mol Biol 44:423-9. 2011
    ..role of the ATP receptor P2X(7) in the pathogenesis of cigarette smoke (CS)-induced lung inflammation and emphysema in vivo...
  44. ncbi Transcription factor Nrf2 plays a pivotal role in protection against elastase-induced pulmonary inflammation and emphysema
    Yukio Ishii
    Department of Respiratory Medicine, University of Tsukuba, Japan
    J Immunol 175:6968-75. 2005
    b>Emphysema is one of the major pathological abnormalities associated with chronic obstructive pulmonary disease...
  45. pmc Cigarette smoke inhibits alveolar repair: a mechanism for the development of emphysema
    Stephen I Rennard
    University of Nebraska Medical Center, Pulmonary and Critical Care Medicine, 985125 Nebraska Medical Center, Omaha, NE 98198 5125, USA
    Proc Am Thorac Soc 3:703-8. 2006
    Classically, emphysema has been believed to develop when mediators of tissue injury exceed protective mechanisms within the lung...
  46. pmc Transconjunctival orbital emphysema caused by compressed air injury: a case report
    Sunu Mathew
    Department of Ophthalmology, St Johns Medical College Hospital, Bangalore, Karnataka, India
    Indian J Ophthalmol 56:247-9. 2008
    Orbital emphysema following conjunctival tear in the absence of orbital wall fracture, caused by air under pressure is rare...
  47. ncbi Premature lung aging and cellular senescence in the pathogenesis of idiopathic pulmonary fibrosis and COPD/emphysema
    Marco Chilosi
    Department of Pathology, University of Verona, Verona, Italy
    Transl Res 162:156-73. 2013
    ..and different pulmonary diseases, including deadly diseases such as chronic obstructive pulmonary disease (COPD)/emphysema and idiopathic pulmonary fibrosis (IPF), can be related to an acceleration of the aging process...
  48. ncbi Antielastin autoimmunity in tobacco smoking-induced emphysema
    Seung Hyo Lee
    Department of Medicine, Section of Pulmonary and Critical Care, Baylor College of Medicine, Houston, Texas 77030, USA
    Nat Med 13:567-9. 2007
    Chronic obstructive pulmonary disease and emphysema are common destructive inflammatory diseases that are leading causes of death worldwide...
  49. ncbi Low-dose volumetric computed tomography for quantification of emphysema in asymptomatic smokers participating in an early lung cancer detection trial
    Gorka Bastarrika
    Department of Radiology, University of Navarra, Pamplona, Spain
    J Thorac Imaging 24:206-11. 2009
    High-resolution computed tomography (CT) is a validated method to quantify the extent of pulmonary emphysema. In this study, we assessed the reliability of low-dose volumetric CT (LDCT) for the quantification of emphysema and its ..
  50. ncbi The relationship between airflow obstruction, emphysema extent, and small airways function in COPD
    Sophie C Timmins
    Woolcock Institute of Medical Research, Australia
    Chest 142:312-9. 2012
    The severities of COPD (FEV(1) % predicted) and airflow obstruction (FEV(1)/FVC) are considered to be due to both emphysema and small airways disease...
  51. pmc The role of collagenase in emphysema
    R Foronjy
    Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    Respir Res 2:348-52. 2001
    ..is essential for the integrity of the lung and when disrupted can lead to the architectural changes seen in emphysema. The etiology of emphysema is believed to be due to an imbalance in the proteases and antiproteases within the ..
  52. ncbi Neutrophil granule proteins in bronchoalveolar lavage fluid from subjects with subclinical emphysema
    T Betsuyaku
    First Department of Medicine, Hokkaido University School of Medicine, Sapporo, Japan
    Am J Respir Crit Care Med 159:1985-91. 1999
    Evidence for the contribution of neutrophils to the pathogenesis of pulmonary emphysema is not convincing...
  53. ncbi Bilateral orbital emphysema and pneumocephalus as a result of accidental compressed air exposure
    Murvet Yuksel
    Department of Radiology, KSU Medical School, 46050, Kahramanmaras, Turkey
    Emerg Radiol 13:195-8. 2007
    Orbital emphysema is a rare condition in the absence of trauma or sinus disease...
  54. ncbi Imaging phenotypes of chronic obstructive pulmonary disease
    Julia Ley-Zaporozhan
    Diagnostic and Interventional Radiology, University Hospital Heidelberg, Heidelberg, Germany
    J Magn Reson Imaging 32:1340-52. 2010
    ..The comprehensive diagnostic possibilities of CT complemented by MRI will allow for a more sensitive detection, phenotype-driven characterization, and dedicated therapy monitoring of the disease...
  55. pmc Fenretinide causes emphysema, which is prevented by sphingosine 1-phoshate
    Masanori Yasuo
    Pulmonary and Critical Care Medicine Division and Victoria Johnson Center for Obstructive Lung Diseases, Virginia Commonwealth University, Richmond, Virginia, United States of America
    PLoS ONE 8:e53927. 2013
    Sphingolipids play a role in the development of emphysema and ceramide levels are increased in experimental models of emphysema; however, the mechanisms of ceramide-related pulmonary emphysema are not fully understood...
  56. ncbi Lung-targeted VEGF inactivation leads to an emphysema phenotype in mice
    Kechun Tang
    Division of Physiology, Univ of California, San Diego, Dept of Medicine 0623A, 9500 Gilman Dr, La Jolla, CA 92093 0623, USA
    J Appl Physiol (1985) 97:1559-66; discussion 1549. 2004
    ..a transient decrease in pulmonary VEGF leads to increased alveolar and bronchial cell apoptosis, air space enlargement, and changes in lung elastic recoil (processes that are characteristic of emphysema) that persist for at least 8 wk.
  57. pmc Lung inflammatory effects, tumorigenesis, and emphysema development in a long-term inhalation study with cigarette mainstream smoke in mice
    Walter Stinn
    Philip Morris Research Laboratories GmbH, 51149 Cologne, Germany
    Toxicol Sci 131:596-611. 2013
    ..Data from this study suggest that the A/J mouse model holds considerable promise as a relevant model for investigating smoking-related emphysema and adenocarcinoma development.
  58. ncbi Protective effects of bone marrow mononuclear cell therapy on lung and heart in an elastase-induced emphysema model
    Fernanda F Cruz
    Laboratory of Pulmonary Investigation, Carlos Chagas Filho Institute of Biophysics, Federal University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil
    Respir Physiol Neurobiol 182:26-36. 2012
    ..mononuclear cell (BMDMC) therapy protects the lung and consequently the heart in experimental elastase-induced emphysema. Twenty-four female C57BL/6 mice were intratracheally instilled with saline (C group) or porcine pancreatic ..
  59. ncbi The presence of emphysema further impairs physiologic function in patients with idiopathic pulmonary fibrosis
    Marco Mura
    Unita Operativa di Fisiopatologia Respiratoria, Policlinico Sant Orsola Malpighi, Bologna, Italy
    Respir Care 51:257-65. 2006
    b>Emphysema, especially in the upper lobes, is frequently observed in association with idiopathic pulmonary fibrosis (IPF). However, the combination of emphysema plus IPF has received little attention.
  60. ncbi Bronchoscopic lung volume reduction coil treatment of patients with severe heterogeneous emphysema
    Dirk Jan Slebos
    Department of Pulmonary Diseases, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands d
    Chest 142:574-82. 2012
    ..LVR-coil), a new experimental device to achieve lung volume reduction by bronchoscopy in patients with severe emphysema, works in a manner unaffected by collateral airflow...
  61. ncbi Differential induction of apoptosis by cigarette smoke extract in primary human lung fibroblast strains: implications for emphysema
    Carolyn J Baglole
    Univ of Rochester School of Medicine and Dentistry, Dept of Environmental Medicine, 601 Elmwood Ave, Rochester, NY 14642, USA
    Am J Physiol Lung Cell Mol Physiol 291:L19-29. 2006
    Cigarette smoke is the principal cause of emphysema. Recent attention has focused on the loss of alveolar fibroblasts in the development of emphysema...
  62. pmc The divergent roles of secreted frizzled related protein-1 (SFRP1) in lung morphogenesis and emphysema
    Robert Foronjy
    Department of Medicine, Columbia University, New York, New York, USA
    Am J Pathol 177:598-607. 2010
    ..SFRP1, an inhibitor of Wnt signaling normally expressed during lung embryogenesis, is induced in the lungs of emphysema patients and in two murine models of the disease...
  63. pmc Elastin fragments drive disease progression in a murine model of emphysema
    A McGarry Houghton
    Division of Pulmonary and Critical Care Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Clin Invest 116:753-9. 2006
    ..or MMP-12) were previously shown to be protected from the development of cigarette smoke-induced emphysema and from the accumulation of lung macrophages normally induced by chronic exposure to cigarette smoke...
  64. ncbi Bronchoscopic volume reduction with valve implants in patients with severe emphysema
    Tudor P Toma
    Department of Thoracic Medicine, National Heart and Lung Institute, London, UK
    Lancet 361:931-3. 2003
    Eight patients with severe emphysema entered a pilot study of unilateral volume reduction by endobronchial valve insertion. Five patients had emphysema judged too severe for volume reduction surgery and three refused the operation...
  65. pmc Cross-sectional analysis of the utility of pulmonary function tests in predicting emphysema in ever-smokers
    Sean E Hesselbacher
    Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Int J Environ Res Public Health 8:1324-40. 2011
    b>Emphysema is largely an under-diagnosed medical condition that can exist in smokers in the absence of airway obstruction...
  66. ncbi Cloning of dexamethasone-induced transcript: a novel glucocorticoid-induced gene that is upregulated in emphysema
    A J Edgar
    Department of Histochemistry, Division of Investigative Sciences, Imperial College School of Medicine, 3rd Floor Chelsea and Westminster Hospital, 369 Fulham Road, London SW10 9NH, UK
    Am J Respir Cell Mol Biol 25:119-24. 2001
    To identify changes in gene expression associated with emphysema, we used differential display to compare RNA extracted from emphysematous lungs with that of unused donor tissues taken at the time of transplant...
  67. ncbi Orbital emphysema
    Scott L Lee
    Ophthalmology 113:2113.e1-2. 2006
  68. ncbi Effect of bronchoscopic lung volume reduction on dynamic hyperinflation and exercise in emphysema
    Nicholas S Hopkinson
    Respiratory Muscle Laboratory, Department of Respiratory Medicine, Royal Brompton Hospital, Fulham Road, London SW3 6NP, UK
    Am J Respir Crit Care Med 171:453-60. 2005
    ..47; p = 0.03). Endobronchial valve placement can improve lung volumes and gas transfer in patients with chronic obstructive pulmonary disease and prolong exercise time by reducing dynamic hyperinflation...
  69. ncbi Alpha1-antitrypsin determines the pattern of emphysema and function in tobacco smoke-exposed mice: parallels with human disease
    Yasutaka Takubo
    Respiratory Division, Royal Victoria Hospital, Meakins Christie Laboratories, McGill University, Montreal, Quebec, Canada
    Am J Respir Crit Care Med 166:1596-603. 2002
    Cigarette smoking in humans is associated with various patterns of emphysema and functional consequences...
  70. ncbi Comparison of standard- and low-radiation-dose CT for quantification of emphysema
    David S Gierada
    Mallinckrodt Institute of Radiology, Washington University School of Medicine, 510 S Kingshighway Blvd, St Louis, MO 63110, USA
    AJR Am J Roentgenol 188:42-7. 2007
    This study was performed to compare standard- and low-radiation-dose techniques in the CT quantification of emphysema.
  71. ncbi Requirement of Fut8 for the expression of vascular endothelial growth factor receptor-2: a new mechanism for the emphysema-like changes observed in Fut8-deficient mice
    Xiangchun Wang
    Department of Disease Glycomics, Institute for Microbial Diseases, Osaka University, Suita, Osaka, Japan
    J Biochem 145:643-51. 2009
    ..Phenotypically, Fut8(-/-) mice exhibit emphysema-like changes in the lung, and severe growth retardation...
  72. ncbi Maximal force is unaffected by emphysema-induced atrophy in extensor digitorium longus
    J P Mattson
    Department of Health and Exercise Science, Gustavus Adolphus College, 800 West College Avenue, St Peter, MN 56082, USA
    Respir Physiol Neurobiol 161:119-24. 2008
    ..Therefore, the purpose of this investigation was to determine whether emphysema-induced muscle fiber atrophy leads to a reduction in locomotory muscle force production...
  73. ncbi Airway malacia in chronic obstructive pulmonary disease: prevalence, morphology and relationship with emphysema, bronchiectasis and bronchial wall thickening
    Nicola Sverzellati
    Department of Clinical Sciences, Section of Radiology, University of Parma, Ospedale Maggiore di Parma, Padiglione Barbieri, V Gramsci 14, 43100, Parma, Italy
    Eur Radiol 19:1669-78. 2009
    ..Both distribution and morphology of airway malacia were assessed. The extent of emphysema, extent of bronchiectasis and severity of bronchial wall thickness were quantified...
  74. ncbi Contrast enhanced CT-scans are not comparable to non-enhanced scans in emphysema quantification
    C P Heussel
    Department of Interventional and Diagnostic Radiology, Thoraxklinik Heidelberg, University Hospital Heidelberg, Amalienstrasse 5, 69126 Heidelberg, Germany
    Eur J Radiol 74:473-8. 2010
    Systemic, interventional and surgical treatments have gone new ways in treatment of emphysema. For longitudinal therapy monitoring and as end-points for clinical trials, quantification of the disease is necessary...
  75. pmc Oxidized {alpha}1-antitrypsin stimulates the release of monocyte chemotactic protein-1 from lung epithelial cells: potential role in emphysema
    Zhenjun Li
    Dept of Medicine, Univ of Cambridge, Addenbrookes Hospital, United Kingdom
    Am J Physiol Lung Cell Mol Physiol 297:L388-400. 2009
    ..Furthermore, these data demonstrate that molecules such as oxidants, antiproteinases, and chemokines, rather than act independently, are likely to interact to cause emphysema.
  76. ncbi Urinary desmosine excretion is inversely correlated with the extent of emphysema in patients with chronic obstructive pulmonary disease
    Franca Cocci
    Istituto di Fisiologia Clinica del Consiglio Nazionale delle Ricerche CNR, Area di Ricerca San Cataldo, Via Moruzzi 1, 56126, Pisa, Italy
    Int J Biochem Cell Biol 34:594-604. 2002
    An enhanced proteolysis of lung interstitium is key event in the pathogenesis of emphysema, a major constituent of chronic obstructive pulmonary disease...
  77. ncbi Report of a workshop: quantitative computed tomography scanning in longitudinal studies of emphysema
    J D Newell
    University of Colorado Health Sciences Center, National Jewish Medical and Research Center, Denver, Colorado 80206, USA
    Eur Respir J 23:769-75. 2004
    ..been reported that quantitative computed tomography (CT) scanning of the lungs showed decreased progression of emphysema in a randomised clinical trial in patients with severe alpha1-antitrypsin (alpha1-AT) deficiency receiving ..
  78. ncbi Prior lung disease and risk of lung cancer in a large prospective study
    Alyson J Littman
    Department of Epidemiology, University of Washington, Seattle, WA, USA
    Cancer Causes Control 15:819-27. 2004
    ..Identifying factors that increase a smoker's risk of developing lung cancer may help scientists to better understand the etiology of lung cancer and more effectively target high-risk groups for screening...
  79. pmc Cigarette smoke-induced emphysema in A/J mice is associated with pulmonary oxidative stress, apoptosis of lung cells, and global alterations in gene expression
    Tirumalai Rangasamy
    Division of Pulmonary and Critical Care Medicine, Univ of Rochester School of Medicine and Dentistry, Rochester, NY 14642 8692, USA
    Am J Physiol Lung Cell Mol Physiol 296:L888-900. 2009
    ..Chip arrays to determine the temporal alterations in global gene expression during the progression of pulmonary emphysema in A/J mice...
  80. pmc Therapeutic efficacy of α-1 antitrypsin augmentation therapy on the loss of lung tissue: an integrated analysis of 2 randomised clinical trials using computed tomography densitometry
    Robert A Stockley
    Lung Investigation Unit, University Hospitals of Birmingham, Edgbaston, Birmingham B15 2TH, UK
    Respir Res 11:136. 2010
    Two randomised, double-blind, placebo-controlled trials have investigated the efficacy of IV alpha-1 antitrypsin (AAT) augmentation therapy on emphysema progression using CT densitometry.
  81. ncbi Pneumonitis and emphysema in sp-C gene targeted mice
    Stephan W Glasser
    Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, Ohio 45229 3039, USA
    J Biol Chem 278:14291-8. 2003
    SP-C-deficient (SP-C -/-) mice developed a severe pulmonary disorder associated with emphysema, monocytic infiltrates, epithelial cell dysplasia, and atypical accumulations of intracellular lipids in type II epithelial cells and alveolar ..
  82. ncbi Risk of lung cancer following nonmalignant respiratory conditions: evidence from two case-control studies in Montreal, Canada
    Agnihotram V Ramanakumar
    Centre de Recherche du CHUM, Universite de Montreal, Montreal, Que, Canada
    Lung Cancer 53:5-12. 2006
    ..II were conducted in 1996-2001 (1205 cases and 1541 controls) and included questions on asthma, tuberculosis, emphysema, and pneumonia...
  83. ncbi Usual interstitial pneumonia and nonspecific interstitial pneumonia with and without concurrent emphysema: thin-section CT findings
    Masanori Akira
    Department of Radiology, National Hospital Organization, Kinki chuo Chest Medical Center, 1180 Nagasone cho, Kita ku, Sakai City, Osaka 591 8555, Japan
    Radiology 251:271-9. 2009
    To determine whether concurrent emphysema influences the distinction between usual interstitial pneumonia (UIP) and nonspecific interstitial pneumonia (NSIP) at thin-section computed tomography (CT).
  84. ncbi Mechanics, nonlinearity, and failure strength of lung tissue in a mouse model of emphysema: possible role of collagen remodeling
    Satoru Ito
    Dept of Biomedical Engineering, Boston Univ, 44 Cummington St, Boston MA 02215, USA
    J Appl Physiol 98:503-11. 2005
    ..with the breakdown and reorganization of the connective tissue fiber network during the development of pulmonary emphysema. In this study, a mouse (C57BL/6) model of emphysema was developed by direct instillation of 1...
  85. pmc Paracrine factors of multipotent stromal cells ameliorate lung injury in an elastase-induced emphysema model
    Ahmed M Katsha
    Department of Respiratory Medicine, Graduate School of Medicine, Tohoku University, Aoba ku, Sendai, Japan
    Mol Ther 19:196-203. 2011
    ..However, although MSCs reduce destruction in an elastase-induced lung emphysema model, MSC differentiation is relatively rare, suggesting that MSC differentiation into specific cells does not ..
  86. pmc Association of COPD candidate genes with computed tomography emphysema and airway phenotypes in severe COPD
    W J Kim
    Channing Laboratory, Brigham and Women s Hospital, Boston, MA, 02115 USA
    Eur Respir J 37:39-43. 2011
    The principal determining factors influencing the development of the airway disease and emphysema components of chronic obstructive pulmonary disease (COPD) have not been clearly defined...
  87. pmc Detection of emphysema progression in alpha 1-antitrypsin deficiency using CT densitometry; methodological advances
    David G Parr
    Department of Respiratory Medicine, University Hospitals of Coventry and Warwickshire, Clifford Bridge Road, Coventry, CV2 2DX, UK
    Respir Res 9:21. 2008
    Computer tomography (CT) densitometry is a potential tool for detecting the progression of emphysema but the optimum methodology is uncertain...
  88. ncbi Quantitative characterization of airspace enlargement in emphysema
    Harikrishnan Parameswaran
    Department of Biomedical Engineering, Boston University, 44 Cummington St, Boston, Massachusetts 02215, USA
    J Appl Physiol 100:186-93. 2006
    ..in recent years, it is most commonly used as an index for characterizing the enlargement of airspaces in emphysema and the associated severity of structural destruction in the lung...
  89. ncbi Roles of mechanical forces and collagen failure in the development of elastase-induced emphysema
    S Kononov
    Department of Biomedical Engineering, Boston University, MA 02215, USA
    Am J Respir Crit Care Med 164:1920-6. 2001
    b>Emphysema causes a permanent destruction of alveolar walls leading to airspace enlargement, loss of elastic recoil, decrease in surface area for gas exchange, lung hyperexpansion, and increased work of breathing...
  90. ncbi Evaluation of micro-CT for emphysema assessment in mice: comparison with non-radiological techniques
    Xabier Artaechevarria
    Cancer Imaging Laboratory, Oncology Division, Center for Applied Medical Research, University of Navarra, 55 Pio XII, 31008 Pamplona, Spain
    Eur Radiol 21:954-62. 2011
    ..potential, limitations and synergies of micro-CT and other non-radiological techniques for the quantification of emphysema and related processes in mice, by performing a complete characterization of the elastase-induced emphysema model.
  91. ncbi Alveolar wall apoptosis causes lung destruction and emphysematous changes
    Kazutetsu Aoshiba
    First Department of Medicine, Tokyo Women s Medical University, Japan
    Am J Respir Cell Mol Biol 28:555-62. 2003
    Pulmonary emphysema is characterized by alveolar wall destruction and airspace enlargement. Recent evidence indicates that epithelial or endothelial apoptosis may be involved in the pathogenesis of emphysema...
  92. ncbi Retinoid treatment of Emphysema in Patients on the Alpha-1 International Registry. The REPAIR study: study design, methodology and quality control of study assessments
    Jan Stolk
    Leiden University Medical Center, P O Box 9600, 2300 RC Leiden, The Netherlands
    Ther Adv Respir Dis 4:319-32. 2010
    b>Emphysema is characterized by the destruction of alveolar wall and enlargement of alveolar airspaces, resulting in a reduction of the total lung gas exchange area, loss of lung elastic recoil and hyperinflation...
  93. ncbi The bronchopulmonary pathology of alpha-1 antitrypsin (AAT) deficiency: findings of the Death Review Committee of the national registry for individuals with Severe Deficiency of Alpha-1 Antitrypsin
    Joseph F Tomashefski
    Department of Pathology, MetroHealth Medical Center and Case Western Reserve University School of Medicine, Cleveland, OH 44109 1998, USA
    Hum Pathol 35:1452-61. 2004
    ..The underlying cause of death was emphysema in 34 patients and cirrhosis in 2 patients...
  94. pmc Anxiety is associated with diminished exercise performance and quality of life in severe emphysema: a cross-sectional study
    Nicholas D Giardino
    Mental Health Service, VA Ann Arbor Healthcare System, Ann Arbor, MI, USA
    Respir Res 11:29. 2010
    ..The purpose of this study is to determine whether there is an association between anxiety and functional measures, quality of life and dyspnea...
  95. ncbi Effects of cigarette smoke exposure and cessation on inflammatory cells and matrix metalloproteinase activity in mice
    Jeanclare Seagrave
    Lovelace Respiratory Research Institute, Albuquerque, New Mexico 87108, USA
    Exp Lung Res 30:1-15. 2004
    ..These results support a role for MMPs in CS-induced emphysema and indicate that smoking cessation allows restoration toward normal homeostasis.
  96. ncbi Bronchoscopic lung-volume reduction with one-way valves in patients with heterogenous emphysema
    Federico Venuta
    Department of Thoracic Surgery, University of Rome La Sapienza, Rome, Italy
    Ann Thorac Surg 79:411-6; discussion 416-7. 2005
    We evaluated the feasibility and short-term functional outcome after bronchoscopic lung-volume reduction performed with one-way valves in patients with severe heterogeneous emphysema.
  97. ncbi A novel oral neutrophil elastase inhibitor (ONO-6818) inhibits human neutrophil elastase-induced emphysema in rats
    Takashige Kuraki
    Department of Respiratory Medicine, School of Medicine, Fukuoka University, 7 45 1 Nanakuma, Jonan ku, Fukuoka 814 0180, Japan
    Am J Respir Crit Care Med 166:496-500. 2002
    ..the effects of a novel oral neutrophil elastase inhibitor (ONO-6818) on acute lung injury and pulmonary emphysema induced by human neutrophil elastase (HNE)...
  98. ncbi Airway dimensions in COPD: relationships with clinical variables
    Grant Mair
    MRC Centre for Inflammation Research, Queen s Medical Research Institute, University of Edinburgh, Edinburgh, United Kingdom
    Respir Med 104:1683-90. 2010
    COPD patients have varying degrees of airways disease and emphysema. CT scanning can differentiate these pathological subtypes...
  99. ncbi Hypoxia inducible factor-1α in human emphysema lung tissue
    M Yasuo
    Pulmonary and Critical Care Medicine Division and Victoria Johnson Center for Obstructive Lung Diseases, Virginia Commonwealth University, Richmond, VA, USA
    Eur Respir J 37:775-83. 2011
    ..study was to assess the expression of hypoxia inducible factor (HIF)-1α in lung tissue from patients with COPD/emphysema. Lung tissue samples from 26 patients were included in this study...
  100. ncbi The association between small airway obstruction and emphysema phenotypes in COPD
    Won Dong Kim
    Division of Pulmonary and Critical Care Medicine, Asan Medical Center, University of Ulsan College of Medicine, 388 1 Pungnap dong, Songpa Gu, Seoul 138 736, Republic of Korea
    Chest 131:1372-8. 2007
    Airflow limitation in COPD is due to a variable combination of small airway obstruction and centrilobular emphysema (CLE) and/or panlobular emphysema (PLE), but the relationship between these three different phenotypes is poorly ..
  101. ncbi Emphysema-induced reductions in locomotory skeletal muscle contractile function
    John P Mattson
    Department of Health and Excercise Science, Adolphus College, 212C Lund Center, 800 West College Avenue, Gustavus Adolphus College, St Peter, MN 56082, USA
    Exp Physiol 90:519-25. 2005
    ..Therefore, the purpose of this investigation was to determine whether emphysema: (1) reduces force production; (2) increases fatigability; and (3) impairs the speed of recovery in locomotory ..

Research Grants74

  1. Regulation of mural cells during pulmonary capillary formation
    Stephen E McGowan; Fiscal Year: 2013
    ..by applicant): PROJECT SUMMARY: The structure and function of alveolar capillaries are deranged in pulmonary emphysema. Restoration of the pulmonary microvasculature is also an important therapeutic goal for interstitial fibrosis ..
  2. Lung Lysyl Oxidase Regulation by Metal Ion Homeostasis
    Wande Li; Fiscal Year: 2013
    ..humans to cadmium (Cd), a heavy metal, either from occupational contamination or from cigarette smoke, induces emphysema and lung cancers. However, the mechanisms for Cd-elicited lung pathology remain poorly understood...
  3. Regulation of Innate and Adaptive Immunity in Human COPD and Emphysema
    Farrah Kheradmand; Fiscal Year: 2012
    ..which puts this group at a very high risk for developing chronic obstructive pulmonary disease (COPD) and emphysema. COPD is characterized by destruction of lung matrix, especially elastin, resulting in loss of elastic recoil, ..
  4. Targeting AP-1 proteins in COPD
    SEKHAR M POTHIREDDY; Fiscal Year: 2010
    ..cells causes enlargement of the alveolar air spaces and lung inflammation, which are cardinal features of emphysema. Interestingly, an elevated level of Fra-1 expression has been reported in the lungs of cigarette smoke-exposed ..
  5. Endotoxin, the airway transcriptome, and obstructive lung disease
    PEGGY SUE LAI; Fiscal Year: 2013
    ..important disease-specific subphenotypes, specifically "exacerbation prone" asthmatics in the school study and "emphysema type" COPD in the textile study...
  6. ROLE OF SIRTUIN IN CIGARETTE SMOKE-INDUCED LUNG INFLAMMATION AND INJURY
    Irfan Rahman; Fiscal Year: 2013
    ..COPD (emphysema and chronic bronchitis) is linked with premature aging (accelerated decline in lung function) and chronic ..
  7. Mechanism Underlying Nitrite Sensitivity of Mucoid Pseudomonas in COPD
    Daniel J Hassett; Fiscal Year: 2013
    ..obstructive pulmonary disease (COPD) is a debilitating lung disorder encompassing chronic bronchitis and/or emphysema, and characterized by nonreversible airflow limitation...
  8. Immune modulators of inflammation in servere COPD
    Farrah Kheradmand; Fiscal Year: 2010
    Tobacco related lung diseases, including chronic obstructive pulmonary disease (COPD) with and without emphysema, are among the major causes of lung-related disability and death worldwide...
  9. The Effects of PP2A on TNF Signaling and Smoke-Induced Lung Injury
    Robert F Foronjy; Fiscal Year: 2013
    ..that superoxide dismutase-1 (SOD1), a lung antioxidant, prevents cigarette smoke-induced inflammation and emphysema formation in mice...
  10. PREVENTION OF QUINONE TOXICITY AND MUTAGENICITY
    ANIL KUMAR JAISWAL; Fiscal Year: 2013
    ..and asthma raise intriguing questions regarding the role of NQO1/NQO2 in cigarette smoke-induced pulmonary emphysema. NQO1-/-, NQO2-/- and DKO mice demonstrated significantly higher susceptibility to develop skin tumors in ..
  11. Dietary Scavenging of Reactive Species in Lung Injury: Role of Macrophages
    THEA NOREEN GOLDEN; Fiscal Year: 2013
    ..of NO production has been implicated in the pathology of numerous respiratory diseases such as asthma, emphysema and the acute respiratory distress syndrome...
  12. Therapeutic use of small-molecule HGF-mimetic for emphysema
    BERT J W M OEHLEN; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Emphysema is a major cause of death and disability and afflicts approximately 2 million people. The disease cost more than $2...
  13. Klotho regulation and aging
    Gwendalyn D King; Fiscal Year: 2010
    ..not unlike what is observed in aged humans (cognitive impairment, atherosclerosis, ectopic calcification, emphysema, osteoporosis, skin atrophy and hair loss, thymic involution, infertility and decreased bone mineral density)...
  14. The RAGE of COPD
    John R Hoidal; Fiscal Year: 2013
    ..paradigm for a central role of the receptor for advanced glycation end products (RAGE) and its ligands in the emphysema pathogenesis...
  15. MNEI/SerpinB1: A modulator of innate pulmonary defense
    EILEEN REMOLD-O'DONNELL; Fiscal Year: 2010
    ..host response leads to lung injury as occurs in patients with cystic fibrosis and COPD (chronic bronchitis, emphysema) will provide understanding that may lead to improved treatment...
  16. Abnormality in Gene Expression of Key Mediators of Vitamin A Action in COPD
    Salil K Das; Fiscal Year: 2010
    Chronic bronchitis and emphysema are two kinds of chronic obstructive pulmonary disease (COPD), which are important causes of morbidity and mortality in the United States...
  17. Developing Nrf2 as a target for treatment of corticosteroid resistance in COPD
    Robert A Wise; Fiscal Year: 2012
    ..Abnormal airway inflammation is thought to contribute to chronic bronchitis, small-airway obstruction and emphysema. Corticosteroids are the most effective anti}} inflammatory drugs prescribed for treating multiple inflammatory ..
  18. Identification of Inhibitors that Stabilize ER Degradation Substrates
    Domenico Tortorella; Fiscal Year: 2012
    ..g. emphysema and cystic fibrosis), blood disorders (e.g. protein C deficiency), and neurological disorders (e.g...
  19. The Unfolded Protein Response in Human Airway and Alveolar Epithelial Cells
    Salim Merali; Fiscal Year: 2010
    ..These latter observations raise the alternative possibility that the UPR may contribute to the pathogenesis of emphysema by inducing cell apoptosis...
  20. Klotho regulation and aging
    GWENDALYN DIANN KING; Fiscal Year: 2013
    ..not unlike what is observed in aged humans (cognitive impairment, atherosclerosis, ectopic calcification, emphysema, osteoporosis, skin atrophy and hair loss, thymic involution, infertility and decreased bone mineral density)...
  21. Toll-like receptor signaling in pathogenesis of pulmonary hypertension
    Yabing Chen; Fiscal Year: 2013
    ..have found that mice deficient in Toll- like receptor 4 (TLR4) are susceptible to lethal oxidant lung injury and emphysema. Consistent with these observations that TLR4 deficiency is important in the development of lung diseases, we ..
  22. RTP-801 in Cigarette Smoke-Emphysema
    Rubin M Tuder; Fiscal Year: 2013
    ..of alveolar structural and molecular maintenance program by cigarette smoke contributes to the pathogenesis of emphysema. The present application is centered on the concept that environmental stresses, such as caused by cigarette ..
  23. Enhancing Nrf2 by Sulforaphane Treatment in COPD
    Robert A Wise; Fiscal Year: 2012
    ..Activation of Nrf2 protects mice from developing emphysema with chronic smoke exposure, decreases oxidative stress, increases proteasomal anti-apoptotic cytoprotective ..
  24. Cardiopulmonary structure and function in Multi-Ethnic Study of Atherosclerosis
    R Graham Barr; Fiscal Year: 2013
    ..of the endothelial hypothesis of COPD is that damage to the pulmonary endothelium occurs early in subclinical emphysema and that such damage may reduce blood flow to the left ventricle (LV)...
  25. Pulmonary Vasoreactivity Following Chronic Hypoxia
    Thomas C Resta; Fiscal Year: 2012
    ..PUBLIC HEALTH RELEVANCE: Chronic obstructive pulmonary diseases (COPD) such as emphysema and chronic bronchitis are established major causes of mortality and morbidity in the U.S...
  26. Role of the Aryl Hydrocarbon Receptor in Lung Inflammation
    PATRICIA JANET SIME; Fiscal Year: 2012
    ..Furthermore, cigarette smoke is the primary cause of chronic obstructive pulmonary disease (COPD-emphysema and chronic bronchitis)...
  27. Novel Protective Antiapoptotic Action of Alpha 1-Antitrypsin In Emphysema
    Rubin M Tuder; Fiscal Year: 2011
    ..of the major pathobiological processes that account for the loss of alveolar septae and tissue destruction in emphysema. Our overall concept underlying this SCCOR proposal is that the interaction of inflammation and apoptotic cell ..
  28. Genome-wide and Linkage Study of Quantitative Emphysema Phenotypes
    Stephen S Rich; Fiscal Year: 2010
    ..Together, emphysema and chronic obstructive pulmonary disease (COPD) will soon surpass stroke as the third leading cause of death in ..
  29. Apoptotic T Cell Clearance From Murine Lungs
    Jeffrey L Curtis; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Significance: Apoptosis is central to the pathogenesis of emphysema, and is widespread in acute lung injury, sepsis, and viral pneumonias...
  30. Phase 2 Study of rAAV1-CB-hAAT for Treatment of Alpha-1 Antitrypsin Deficiency
    Jeffrey D Chulay; Fiscal Year: 2013
    ..condition characterized by reduced serum levels of alpha-1 antitrypsin (AAT) and increased risk of developing emphysema and liver disease, which affects up to 100,000 individuals in the United States...
  31. Imaging regional physiologic parameters of lung function
    Rahim R Rizi; Fiscal Year: 2011
    ..However, these non-invasive methods have not, as yet, been used to characterize the underlying mechanisms of emphysema. The objectives of the current proposal are to use these non-invasive hyperpolarized helium-3 MRI parameters for ..
  32. Using Vessel Caliber to Assess Cardiac Impairment in COPD
    Carolyn E Come; Fiscal Year: 2013
    ..In her second aim, using data from the National Emphysema Treatment Trial, she will assess the effect of lung deflation (via lung volume reduction surgery) and ..
  33. MECHANISMS OF CIGARETTE SMOKE-INDUCED LUNG CELLULAR SENESCENCE
    Irfan Rahman; Fiscal Year: 2013
    ..that lead to DNA damage and cellular senescence, however, as well as their roles in the development of COPD/emphysema are not known...
  34. In vitro and in vivo efficacy of liposomal ciprofloxacin formulations against Myc
    Igor Gonda; Fiscal Year: 2013
    ..are common in patients with chronic lung conditions, such as cystic fibrosis (CF), non-CF bronchiectasis and emphysema. In patients with AIDS, the M. avium infection is disseminated...
  35. Mechanisms of COPD Subphenotype Development
    MICHAEL BRADLEY DRUMMOND; Fiscal Year: 2013
    ..induces pro-inflammatory cytokines and increased apoptosis within the lung, leading to airways remodeling and emphysema-predominant subphenotypes of COPD...
  36. Role of Anti-aging Klotho Gene on Adaptation to Oxidative Stress
    Priya Ravikumar; Fiscal Year: 2013
    ..Conversely, hyperoxia produces excess ROS that induce alveolar degeneration resembling emphysema. Hence, both hypoxia and hyperoxia impose oxidative stress on the lung...
  37. Lung Endothelial Cell Apoptosis and Emphysema
    SHARON IRENE SMITH ROUNDS; Fiscal Year: 2013
    ..and there is growing evidence that apoptosis of alveolar wall cells plays a role in the development of emphysema. The overall objective of this proposal is to understand mechanisms of CS-induced lung EC apoptosis and ..
  38. Respiratory Muscle Weakness in Chronic Inflammation
    Francisco H Andrade; Fiscal Year: 2013
    ..PUBLIC HEALTH RELEVANCE: Chronic inflammatory diseases, including heart failure and emphysema, weaken the muscles used for breathing...
  39. Human NRF2 Promoter Functional Polymorphisms and Acute Lung Injury
    Sekhar P Reddy; Fiscal Year: 2012
    Many patients with pulmonary diseases, such as acute respiratory distress syndrome and emphysema, require hyperoxia to maintain adequate tissue oxygenation...
  40. The Role of Complement in the Pathogenesis of Emphysema
    Carl Atkinson; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The single most important factor in the development of emphysema is cigarette smoke inhalation...
  41. Signaling Sphingolipids in COPD
    Irina Petrache; Fiscal Year: 2009
    ..recently identified a novel role for ceramides in the lung as a central mediator of alveolar cell apoptosis and emphysema. Signaling sphingolipids are essential for ensuring an optimal balance of cell death (ceramides) / survival (..
  42. Role of nAChR stoichiometry in nicotine-induced upregulation
    CHRISTOPHER I RICHARDS; Fiscal Year: 2012
    ..millions of cancer deaths every year and is also a leading factor in many other heart and lung diseases such as emphysema and vascular disease...
  43. Role of Elastolytic Cathepsins in Emphysema
    Harold A Chapman; Fiscal Year: 2010
    Accumulating evidence indicates papain-family cysteine proteases are involved in the pathobiology of emphysema. One of these enzymes, cathepsin S, is a potent extracellular elastase stable at neutral pH and also a key endosomal acidic ..
  44. CIRCADIAN-COUPLED CELLULAR AND LUNG FUNCTION IN COPD
    Irfan Rahman; Fiscal Year: 2012
    ..lung inflammation and steroid resistance associated with decline in lung function in mouse model of COPD/emphysema and its exacerbations...
  45. Direct and Bone-Marrow Mediated Effects of Adipose Stem Cells in Emphysema
    Irina Petrache; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Pulmonary emphysema is a prevalent lung disease defined by permanent enlargement of airspaces, but also associated with systemic effects on organs that include the bone marrow and the cardiovascular ..
  46. Pathophysiology of PPARgamma in the lung
    Hong Du; Fiscal Year: 2012
    ..blockage of its ligand synthesis in lysosomal acid lipase deficient mice (lal-/-) caused pulmonary inflammation, emphysema, unwanted epithelial cell growth and aberrant gene expression...
  47. Pathogenic Mechanism for Lung Infection in Mucoid Pseudomonas
    DENNIS EDWARD OHMAN; Fiscal Year: 2013
    ..This can occur as a complication of emphysema, chronic bronchitis, cancer and immunosuppressive drug therapy...
  48. Lung Genomics Research Consortium
    AVRUM E SPIRA; Fiscal Year: 2010
    ..COPD/emphysema is the fourth leading cause of death in the United States and the incidence and rate of death from pulmonary ..
  49. Shared Mechanisms of Pulmonary Lymphocyte Activation by Bacteria and Toxicants
    Michael Borchers; Fiscal Year: 2010
    ..transgenic mouse model will allow us to dissect the mechanisms of epithelial cell-lymphocyte interactions in emphysema. The successful completion of these studies will provide a better understanding of the pathways and mechanisms ..
  50. HTS Approach to Correction of Alpha-1-Antitrypsin Misfolding Disease
    William Balch; Fiscal Year: 2009
    ..a critical need for novel HTS strategies to identify small molecules that will benefit the disease early-onset emphysema including childhood emphysema, a disease related to deficiency in alpha-1-antitrypsin (11AT) in the lung...
  51. Interactions of smoking, PD-1 and IL-10 in HIV-associated lung disease
    Brent E Palmer; Fiscal Year: 2013
    ..observed in HIV-1-uninfected populations, and a subset of HIV-1-infected smokers develop an accelerated form of emphysema. However, the mechanisms underlying the increased risk of pneumonia and COPD in HIV-1-infected individuals are ..
  52. Metabolome and proteome profiles of emphysema and airway disease
    RUSSELL PAUL BOWLER; Fiscal Year: 2012
    ..Two of the most common phenotypes include emphysema and airway disease;these phenotypes are poorly correlated with spirometry and have clinical implications ..
  53. Th1 and Th17 Mediators in Experimental Emphysema
    Farrah Kheradmand; Fiscal Year: 2013
    ..We have demonstrated that a subtype of smokers who develop emphysema harbor autoimmune inflammation, characterized by the presence of elastin- specific T helper type 1 (Th1) and ..
  54. Novel Molecules in Airway Epithelial Endoplasmic Reticulum
    Bradley W Schroeder; Fiscal Year: 2012
    ..These studies will aid our understanding of the cellular processes underlying excessive mucus production in diseases such as asthma, emphysema, and cystic fibrosis.
  55. Neural Plasticity During Acclimatization to Hypoxia
    Frank L Powell; Fiscal Year: 2013
    ..will test the hypothesis that CSH causes similar molecular signals for plasticity in a transgenic mouse model of emphysema (conditional deletion of the vascular endothelial growth factor gene in the lung)...
  56. Novel Reagents in Mouse Models of Autoimmune COPD
    Michael Borchers; Fiscal Year: 2012
    ..COPD, which includes chronic bronchitis and emphysema, is a major global health burden and morbidity and mortality are expected to expand in the next decades...
  57. Predictive Modeling with Clinical and Genomic Data in COPD
    PETER CASTALDI; Fiscal Year: 2013
    ..to maximize the information obtained from genomic data, we will combine data from multiple studies (the National Emphysema Treatment Trial Genetics Ancillary Study, the Norway Case-Control Study, COPDGene, and ECLIPSE - total sample ..
  58. HIV+ Alveolar Macrophage Oxidant-mediated Apoptosis of Pulmonary Endothelium
    Steven S Gross; Fiscal Year: 2013
    ..with HIV have an increased risk for the development of chronic obstructive pulmonary disease, manifesting as emphysema. The emphysema occurs at an earlier age than in HIV- smokers, and is recognized as an increasing cause of ..
  59. PGP, A Possible Biomarker for COPD Exacerbations and or Progression
    J Edwin Blalock; Fiscal Year: 2013
    ..plasma, and urine of COPD patients with numerous disease parameters, in particular exacerbations, degree of emphysema and disease progression...
  60. Cigarette Smoke and Autophagy/Lysosomal Pathway Dysfunction
    Martha M Monick; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Emphysema/COPD poses an ever-increasing threat to world health...
  61. Autophagy in COPD
    George R Washko; Fiscal Year: 2010
    ..We further hypothesize that autophagy plays a critical determinant in airway disease and emphysema in COPD. To test this hypothesis, we will address the following Specific Aims: Aim 1...
  62. Recombinant alpha1-Antitrypsin Therapeutics
    XINLI HENRY LIN; Fiscal Year: 2010
    ..Inherited deficiency of AAT predisposes individuals to early onset hereditary emphysema. In addition, AAT deficiency also contributes to conditions such as emphysema caused by smoking, cystic fibrosis,..
  63. Experimental COPD: remediation, mitigation
    DONALD JOHN MASSARO; Fiscal Year: 2010
    ..factor receptor induces alveolar regeneration and increases lung tissue recoil in mice with elastase induced emphysema. It is supported by 1) protein level confirmation of microarray measured global gene expression in lung and 2) ..
  64. HE3 MR Diffusion & Low Dose CT Quantitation of Emphysema
    David Gierada; Fiscal Year: 2005
    ..magnetic resonance imaging (He-3 dMRI) and low dose quantitative computed tomography (LD-QCT) indexes of emphysema as noninvasive biomarkers for the presence, severity, and progression of emphysema...
  65. EMPHYSEMA--INFLUENCES ON DIAPHRAGM FATIGUE RESISTANCE
    Michael Lewis; Fiscal Year: 1992
    ..In malnutrition, oxidative capacity of skeletal muscle fibers has been shown to be decreased, while in emphysema it has been shown to be increased...
  66. Quantitative MRI-based Assessment of Aerosol Deposition in the Lung
    Chantal Darquenne; Fiscal Year: 2009
    ..to measure aerosol DE patterns in a rat model;and 2) apply this technique to characterize the effects of emphysema on aerosol DE patterns...
  67. Hyperpolarized xenon functional MRI of human lung microstructure
    IULIAN RUSET; Fiscal Year: 2009
    Chronic Obstructive Pulmonary Disease (COPD), including emphysema and chronic bronchitis, is the fourth leading cause of death in the US, accounting for 120,000 fatalities annually...
  68. PLAGL2 Expression in Emphysema Patient Lungs
    Yih Sheng Yang; Fiscal Year: 2009
    ..Lungs from transgenic mice developed an accelerated form of centrilobular emphysema following doxycycline (Dox) induction of PLAGL2 expression in type II and bronchiolar epithelial cells...
  69. ALPHA-1-PROTEINASE INHIBITOR DEFICIENCY AND EMPHYSEMA
    Savio Woo; Fiscal Year: 1990
    ..of Alpha1-antitrypsin predisposes affected individuals to development of chronic obstructive pulmonary emphysema. The deficiency is inherited as an autosomal recessive trait, and there is no cure for the genetic disorder at ..
  70. UNCLASSIFIED SPIROMETRIC ABNORMALITIES: RADIOLOGY, EPIDEMIOLOGY, AND GENETICS
    Edwin K Silverman; Fiscal Year: 2010
    Chronic obstructive pulmonary disease (COPD) includes both emphysema and small airway disease...
  71. VENTING FOR REDUCTION OF HYPERINFLATION IN EMPHYSEMA
    Joel Cooper; Fiscal Year: 2005
    Description (provided by applicant) Emphysema affects approximately 2 million individuals in the US and is the fourth leading cause of death...
  72. EMPHYSEMA: OUTCOMES AND TECHNOLOGY ASSESSMENT
    Roger Yusen; Fiscal Year: 2004
    This project seeks to improve outcomes in patients with emphysema. Therapies such as lung volume reduction surgery (LVRS) and lung transplantation (LTx) offer potential improvements in quality of life, but they impose substantial risks...
  73. Hyperpolarized Xenon functional MRI of human lungs
    Farhod Nozirov; Fiscal Year: 2006
    ..b>Emphysema is characterized by a sudden irreversible decay of lung tissue, reducing the surface area for gas exchange while ..
  74. Influence of spatial patterns of ventilation & perfusion on gas exchange in COPD
    Angela Henderson; Fiscal Year: 2009
    ..flow, and effects of HPV on the distribution of blood flow in COPD reflect whether the disease is predominantly emphysema (lung tissue destruction) or predominantly airway disease...