recurrence

Summary

Summary: The return of a sign, symptom, or disease after a remission.

Top Publications

  1. ncbi A multigene assay to predict recurrence of tamoxifen-treated, node-negative breast cancer
    Soonmyung Paik
    Division of Pathology, Operation Center, and the Biostatistics Center, National Surgical Adjuvant Breast and Bowel Project, Pittsburgh 15212, USA
    N Engl J Med 351:2817-26. 2004
  2. ncbi A serum autoantibody marker of neuromyelitis optica: distinction from multiple sclerosis
    Vanda A Lennon
    Department of Neurology, Mayo Clinic Rochester, Rochester, MN 55905, USA
    Lancet 364:2106-12. 2004
  3. ncbi Gene expression and benefit of chemotherapy in women with node-negative, estrogen receptor-positive breast cancer
    Soonmyung Paik
    Division of Pathology, Operations Center, and Biostatistical Center, National Surgical Adjuvant Breast and Bowel Project, Pittsburgh, PA 15212, USA
    J Clin Oncol 24:3726-34. 2006
  4. pmc Determinants of relapse periodicity in Plasmodium vivax malaria
    Nicholas J White
    Mahidol Oxford Tropical Medicine Research Unit, Mahidol University, Bangkok, Thailand
    Malar J 10:297. 2011
  5. ncbi Relapses of Plasmodium vivax infection usually result from activation of heterologous hypnozoites
    Mallika Imwong
    Department of Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    J Infect Dis 195:927-33. 2007
  6. pmc Prognostic and predictive value of the 21-gene recurrence score assay in postmenopausal women with node-positive, oestrogen-receptor-positive breast cancer on chemotherapy: a retrospective analysis of a randomised trial
    Kathy S Albain
    Loyola University Chicago Stritch School of Medicine, Cardinal Bernardin Cancer Center, Maywood, IL, USA
    Lancet Oncol 11:55-65. 2010
  7. ncbi Natalizumab plus interferon beta-1a for relapsing multiple sclerosis
    Richard A Rudick
    Mellen Center for Multiple Sclerosis Treatment and Research, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    N Engl J Med 354:911-23. 2006
  8. doi Fidaxomicin versus vancomycin for Clostridium difficile infection
    Thomas J Louie
    University of Calgary, Calgary, AB, Canada
    N Engl J Med 364:422-31. 2011
  9. doi International consensus recommendations on the management of patients with nonvariceal upper gastrointestinal bleeding
    Alan N Barkun
    Division of Gastroenterology, Montreal General Hospital Site, McGill University Health Centre, Montreal, Quebec, Canada
    Ann Intern Med 152:101-13. 2010
  10. ncbi Shape of the relapse curve and long-term abstinence among untreated smokers
    John R Hughes
    University of Vermont, Department of Psychiatry, Burlington, VT 05401 1419, USA
    Addiction 99:29-38. 2004

Research Grants

  1. High Throughput Genotyping and DNA Sequencing for Studying the Genetic Contributi
    Sonia Dua; Fiscal Year: 2013
  2. Cardiotrophin-Like Cytokine 1, a Candidate Molecule for the FSGS Factor
    Virginia J Savin; Fiscal Year: 2010
  3. Craig T Morita; Fiscal Year: 2016
  4. Clinical , Mechanical and Chemical Evaluation of Amalgam and ART Restorations
    Lilliam Marie Pinzon; Fiscal Year: 2013
  5. Scott J Hultgren; Fiscal Year: 2015
  6. C. Difficile Outcomes and Effectiveness of Treatment Strategies in SCI
    Charlesnika T Evans; Fiscal Year: 2013
  7. Enhancing radiation and cisplatin HNSCC cell killing by inhibiting mitochondrial
    Lynn Harrison; Fiscal Year: 2013
  8. Biomarkers to Assess Selenium Chemoprevention for NSCLC
    Steven A Belinsky; Fiscal Year: 2012
  9. Chemoprevention of urinary bladder carcinogenesis by flavokawain A
    Xiaolin Zi; Fiscal Year: 2012
  10. Rachel M Ceballos; Fiscal Year: 2015

Detail Information

Publications527 found, 100 shown here

  1. ncbi A multigene assay to predict recurrence of tamoxifen-treated, node-negative breast cancer
    Soonmyung Paik
    Division of Pathology, Operation Center, and the Biostatistics Center, National Surgical Adjuvant Breast and Bowel Project, Pittsburgh 15212, USA
    N Engl J Med 351:2817-26. 2004
    The likelihood of distant recurrence in patients with breast cancer who have no involved lymph nodes and estrogen-receptor-positive tumors is poorly defined by clinical and histopathological measures.
  2. ncbi A serum autoantibody marker of neuromyelitis optica: distinction from multiple sclerosis
    Vanda A Lennon
    Department of Neurology, Mayo Clinic Rochester, Rochester, MN 55905, USA
    Lancet 364:2106-12. 2004
    ..We assessed the capacity of a putative marker for neuromyelitis optica (NMO-IgG) to distinguish neuromyelitis optica and related disorders from multiple sclerosis...
  3. ncbi Gene expression and benefit of chemotherapy in women with node-negative, estrogen receptor-positive breast cancer
    Soonmyung Paik
    Division of Pathology, Operations Center, and Biostatistical Center, National Surgical Adjuvant Breast and Bowel Project, Pittsburgh, PA 15212, USA
    J Clin Oncol 24:3726-34. 2006
    The 21-gene recurrence score (RS) assay quantifies the likelihood of distant recurrence in women with estrogen receptor-positive, lymph node-negative breast cancer treated with adjuvant tamoxifen...
  4. pmc Determinants of relapse periodicity in Plasmodium vivax malaria
    Nicholas J White
    Mahidol Oxford Tropical Medicine Research Unit, Mahidol University, Bangkok, Thailand
    Malar J 10:297. 2011
    ..Long-latency P. vivax phenotypes may be more widespread and more prevalent than currently thought. These observations have important implications for the assessment of radical treatment efficacy and for malaria control and elimination...
  5. ncbi Relapses of Plasmodium vivax infection usually result from activation of heterologous hypnozoites
    Mallika Imwong
    Department of Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    J Infect Dis 195:927-33. 2007
    ..Thus, reappearance of parasitemia after treatment can result from relapse, recrudescence, or reinfection. It has been assumed that parasites causing relapse would be a subset of the parasites that caused the primary infection...
  6. pmc Prognostic and predictive value of the 21-gene recurrence score assay in postmenopausal women with node-positive, oestrogen-receptor-positive breast cancer on chemotherapy: a retrospective analysis of a randomised trial
    Kathy S Albain
    Loyola University Chicago Stritch School of Medicine, Cardinal Bernardin Cancer Center, Maywood, IL, USA
    Lancet Oncol 11:55-65. 2010
    The 21-gene recurrence score assay is prognostic for women with node-negative, oestrogen-receptor-positive breast cancer treated with tamoxifen. A low recurrence score predicts little benefit of chemotherapy...
  7. ncbi Natalizumab plus interferon beta-1a for relapsing multiple sclerosis
    Richard A Rudick
    Mellen Center for Multiple Sclerosis Treatment and Research, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    N Engl J Med 354:911-23. 2006
    ..Despite interferon beta therapy, many patients have relapses. Natalizumab, an alpha4 integrin antagonist, appeared to be safe and effective alone and when added to interferon beta-1a in preliminary studies...
  8. doi Fidaxomicin versus vancomycin for Clostridium difficile infection
    Thomas J Louie
    University of Calgary, Calgary, AB, Canada
    N Engl J Med 364:422-31. 2011
    ..Patients generally have a response to oral vancomycin or metronidazole; however, the rate of recurrence is high...
  9. doi International consensus recommendations on the management of patients with nonvariceal upper gastrointestinal bleeding
    Alan N Barkun
    Division of Gastroenterology, Montreal General Hospital Site, McGill University Health Centre, Montreal, Quebec, Canada
    Ann Intern Med 152:101-13. 2010
    ..A multidisciplinary group of 34 experts from 15 countries developed this update and expansion of the recommendations on the management of acute nonvariceal upper gastrointestinal bleeding (UGIB) from 2003...
  10. ncbi Shape of the relapse curve and long-term abstinence among untreated smokers
    John R Hughes
    University of Vermont, Department of Psychiatry, Burlington, VT 05401 1419, USA
    Addiction 99:29-38. 2004
    ..To describe the relapse curve and rate of long-term prolonged abstinence among smokers who try to quit without treatment...
  11. ncbi Trastuzumab plus adjuvant chemotherapy for operable HER2-positive breast cancer
    Edward H Romond
    National Surgical Adjuvant Breast and Bowel Project, Pittsburgh, USA
    N Engl J Med 353:1673-84. 2005
    ..We present the combined results of two trials that compared adjuvant chemotherapy with or without concurrent trastuzumab in women with surgically removed HER2-positive breast cancer...
  12. ncbi A randomized, placebo-controlled trial of natalizumab for relapsing multiple sclerosis
    Chris H Polman
    Vrije Universiteit Medical Center, Amsterdam, The Netherlands
    N Engl J Med 354:899-910. 2006
    ..Natalizumab is the first alpha4 integrin antagonist in a new class of selective adhesion-molecule inhibitors. We report the results of a two-year phase 3 trial of natalizumab in patients with relapsing multiple sclerosis...
  13. pmc Recurrence risk for autism spectrum disorders: a Baby Siblings Research Consortium study
    Sally Ozonoff
    Department of Psychiatry, University of California Davis, Sacramento, California 95817, USA
    Pediatrics 128:e488-95. 2011
    The recurrence risk of autism spectrum disorders (ASD) is estimated to be between 3% and 10%, but previous research was limited by small sample sizes and biases related to ascertainment, reporting, and stoppage factors...
  14. doi Decreased diversity of the fecal Microbiome in recurrent Clostridium difficile-associated diarrhea
    Ju Young Chang
    Department of Microbiology and Molecular Genetics, Michigan State University, East Lansing, MI, USA
    J Infect Dis 197:435-8. 2008
    ..Preservation and restoration of the microbial diversity could represent novel strategies for prevention and treatment of recurrent CDAD, which is often recalcitrant to existing therapies...
  15. pmc In vivo parasitological measures of artemisinin susceptibility
    Kasia Stepniewska
    Mahidol Oxford Tropical Medicine Research Unit, Mahidol University, Bangkok, Thailand
    J Infect Dis 201:570-9. 2010
    ....
  16. doi Systematic review of the epidemiology of complicated peptic ulcer disease: incidence, recurrence, risk factors and mortality
    James Y Lau
    Department of Surgery, Chinese University of Hong Kong, Hong Kong, SAR, China
    Digestion 84:102-13. 2011
    ..This systematic review aimed to determine the incidence, recurrence and mortality of complicated peptic ulcer and the risk factors associated with these events.
  17. pmc Circulating mutant DNA to assess tumor dynamics
    Frank Diehl
    The Ludwig Center for Cancer Genetics and Therapeutics, Howard Hughes Medical Institute and Sidney Kimmel Cancer Center at the Johns Hopkins Medical Institutions, Baltimore, Maryland 21231, USA
    Nat Med 14:985-90. 2008
    ..We suggest that this personalized genetic approach could be generally applied to individuals with other types of cancer...
  18. pmc Amplification of LAPTM4B and YWHAZ contributes to chemotherapy resistance and recurrence of breast cancer
    Yang Li
    Department of Cancer Biology, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, USA
    Nat Med 16:214-8. 2010
    Adjuvant chemotherapy for breast cancer after surgery has effectively lowered metastatic recurrence rates. However, a considerable proportion of women suffer recurrent cancer at distant metastatic sites despite adjuvant treatment...
  19. pmc Antibody to aquaporin-4 in the long-term course of neuromyelitis optica
    S Jarius
    Neurosciences Group, Weatherall Institute of Molecular Medicine, and Department of Neurology, John Radcliffe Hospital, University of Oxford, UK
    Brain 131:3072-80. 2008
    ..Our results demonstrate a strong relationship between AQP4-Abs and clinical state, and support the hypothesis that these antibodies are involved in the pathogenesis of NMO...
  20. ncbi Anti-aquaporin-4 antibody is involved in the pathogenesis of NMO: a study on antibody titre
    Toshiyuki Takahashi
    Department of Neurology, Tohoku University Graduate School of Medicine, 1 1 Seiryomachi, Aobaku, Sendai 980 8574, Japan
    Brain 130:1235-43. 2007
    ....
  21. pmc Oligometastases and oligo-recurrence: the new era of cancer therapy
    Yuzuru Niibe
    Department of Radiaion Oncology, Kitasato University School of Medicine, Sagamihara, Kanagawa, Japan
    Jpn J Clin Oncol 40:107-11. 2010
    b>Recurrence or metastasis of cancer has been considered to occur in the last stage of the patient's life...
  22. pmc Hsa-mir-124-3 CpG island methylation is associated with advanced tumours and disease recurrence of patients with clear cell renal cell carcinoma
    K Gebauer
    Department of Urology, Hannover Medical School, OE6247, Carl Neuberg Str 1, 30625 Hannover, Germany
    Br J Cancer 108:131-8. 2013
    ....
  23. doi NMO-IgG predicts the outcome of recurrent optic neuritis
    M Matiello
    Department of Neurology, Mayo Clinic College of Medicine, 200 First St SW, Rochester, MN 55905, USA
    Neurology 70:2197-200. 2008
    ..Recurrent ON may herald multiple sclerosis (MS) or NMO, or it may occur as an isolated syndrome. The prognosis and response to therapy differs in each of these contexts...
  24. doi Pain and ovarian endometrioma recurrence after laparoscopic treatment of endometriosis: a long-term prospective study
    Maria Grazia Porpora
    Department of Gynecology and Obstetrics, University of Rome Sapienza, Viale Regina Elena, 324 00161 Rome, Italy
    Fertil Steril 93:716-21. 2010
    To identify prognostic factors for pain and endometrioma recurrence after complete laparoscopic excision of endometrioma(s).
  25. pmc Statin prescriptions and breast cancer recurrence risk: a Danish nationwide prospective cohort study
    Thomas P Ahern
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 181 Longwood Ave, Rm 355, Boston, MA 02115, USA
    J Natl Cancer Inst 103:1461-8. 2011
    ..Though many studies have reported an association between statin use and breast cancer incidence, the relationship between statin use and breast cancer recurrence has not been well studied.
  26. doi Eculizumab for atypical hemolytic uremic syndrome recurrence in renal transplantation
    J Zuber
    Assistance Publique Hopitaux de Paris, Hôpital Necker Université Paris Descartes, Sorbonne Paris Cité Department of Renal Transplantation, Paris, France
    Am J Transplant 12:3337-54. 2012
    ..any firm conclusion about the optimal use of anti-C5 for preventing or treating aHUS posttransplant aHUS recurrence. We thoroughly studied 22 renal transplant recipients with aHUS who received off-label therapy with anti-C5, ..
  27. ncbi A phase 2 study of bortezomib in relapsed, refractory myeloma
    Paul G Richardson
    Department of Adult Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    N Engl J Med 348:2609-17. 2003
    ..Bortezomib, a boronic acid dipeptide, is a novel proteasome inhibitor that has been shown in preclinical and phase 1 studies to have antimyeloma activity...
  28. doi n-3 polyunsaturated fatty acids for the prevention of arrhythmia recurrence after electrical cardioversion of chronic persistent atrial fibrillation: a randomized, double-blind, multicentre study
    Leopoldo Bianconi
    Department of Cardiology, San Filippo Neri Hospital, University of Tor Vergata, Rome, Italy
    Europace 13:174-81. 2011
    ..properties even at the atrial level, we aimed to evaluate whether oral supplementation with PUFAs, in addition to conventional antiarrhythmic drugs, could reduce the recurrence rate of the arrhythmia after ECV of persistent AF.
  29. doi Impact of donor and recipient IL28B rs12979860 genotypes on hepatitis C virus liver graft reinfection
    Christian M Lange
    Medizinische Klinik 1, Klinikum der J W Goethe Universität Frankfurt am Main, D 60590 Frankfurt am Main, Germany
    J Hepatol 55:322-7. 2011
    ..We therefore, aimed to explore the impact of donor and recipient genotypes of these polymorphisms on hepatitis C virus (HCV) liver graft reinfection...
  30. pmc Ketones and lactate increase cancer cell "stemness," driving recurrence, metastasis and poor clinical outcome in breast cancer: achieving personalized medicine via Metabolo-Genomics
    Ubaldo E Martinez-Outschoorn
    The Jefferson Stem Cell Biology and Regenerative Medicine Center, Thomas Jefferson University, Philadelphia, PA, USA
    Cell Cycle 10:1271-86. 2011
    ..The lactate- and ketone-induced "gene signatures" were able to predict poor clinical outcome (including recurrence and metastasis) in a cohort of human breast cancer patients...
  31. pmc Absorbable versus silk sutures for surgical treatment of trachomatous trichiasis in Ethiopia: a randomised controlled trial
    Saul N Rajak
    The London School of Hygiene and Tropical Medicine, London, United Kingdom
    PLoS Med 8:e1001137. 2011
    ..Trichiasis can recur after corrective surgery. We tested the hypothesis that using absorbable sutures instead of silk sutures might reduce the risk of recurrent disease among patients with major trichiasis in a randomised trial...
  32. ncbi High-dose atorvastatin after stroke or transient ischemic attack
    Pierre Amarenco
    Denis Diderot University, Paris
    N Engl J Med 355:549-59. 2006
    ..Statins reduce the incidence of strokes among patients at increased risk for cardiovascular disease; whether they reduce the risk of stroke after a recent stroke or transient ischemic attack (TIA) remains to be established...
  33. pmc Salvage regimens with autologous transplantation for relapsed large B-cell lymphoma in the rituximab era
    Christian Gisselbrecht
    Hopital Saint Louis, 1 avenue Claude Vellefaux, 75010 Paris, France
    J Clin Oncol 28:4184-90. 2010
    ..Salvage regimens have never been compared; their efficacy in the rituximab era is unknown...
  34. pmc MicroRNA profiling and prediction of recurrence/relapse-free survival in stage I lung cancer
    Yan Lu
    Department of Physiology and Cancer Center, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Carcinogenesis 33:1046-54. 2012
    ..expression profiles were analyzed for their association with cancer subtypes, lung cancer brain metastasis and recurrence/relapse free survival (RFS)...
  35. pmc Sibling recurrence and the genetic epidemiology of autism
    John N Constantino
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
    Am J Psychiatry 167:1349-56. 2010
    Although the symptoms of autism exhibit quantitative distributions in nature, estimates of recurrence risk in families have never previously considered or incorporated quantitative characterization of the autistic phenotype among siblings.
  36. pmc DNA mismatch repair status and colon cancer recurrence and survival in clinical trials of 5-fluorouracil-based adjuvant therapy
    Frank A Sinicrope
    Division of Oncology, Mayo Clinic, Rochester, MN 55905, USA
    J Natl Cancer Inst 103:863-75. 2011
    ..We determined the association of MMR status with colon cancer recurrence and examined the impact of 5-fluorouracil (FU)-based adjuvant therapy on recurrence variables.
  37. ncbi International Subarachnoid Aneurysm Trial (ISAT) of neurosurgical clipping versus endovascular coiling in 2143 patients with ruptured intracranial aneurysms: a randomised trial
    Andrew Molyneux
    ISAT, Neurovascular Research Unit, Radcliffe Infirmary, Oxford OX2 6HE, UK
    Lancet 360:1267-74. 2002
    ..We undertook a randomised, multicentre trial to compare the safety and efficacy of endovascular coiling with standard neurosurgical clipping for such aneurysms judged to be suitable for both treatments...
  38. ncbi Recurrence of ischemic placental disease
    Cande V Ananth
    Department of Obstetrics, Gynecology, and Reproductive Sciences, UMDNJ Robert Wood Johnson Medical School, New Brunswick, New Jersey 08901 1977, USA
    Obstet Gynecol 110:128-33. 2007
    ..To test the hypothesis that the presence of preeclampsia, small for gestational age (SGA)-birth, and placental abruption in the first pregnancy confers increased risk in the second pregnancy...
  39. doi Value of mismatch repair, KRAS, and BRAF mutations in predicting recurrence and benefits from chemotherapy in colorectal cancer
    Gordon Hutchins
    Leeds Institute of Molecular Medicine, Leeds University, United Kingdom
    J Clin Oncol 29:1261-70. 2011
    ..We investigated the usefulness of defective mismatch repair (dMMR), BRAF, and KRAS mutations in predicting tumor recurrence and sensitivity to chemotherapy.
  40. pmc Influence of preceding length of anticoagulant treatment and initial presentation of venous thromboembolism on risk of recurrence after stopping treatment: analysis of individual participants' data from seven trials
    Florent Boutitie
    Hospices Civils de Lyon, Service de Biostatistique, UMR, CHU de Lyon, France
    BMJ 342:d3036. 2011
    ..how length of anticoagulation and clinical presentation of venous thromboembolism influence the risk of recurrence after anticoagulant treatment is stopped and to identify the shortest length of anticoagulation that reduces the ..
  41. ncbi Predictors of relapse following response from a first episode of schizophrenia or schizoaffective disorder
    D Robinson
    Department of Psychiatry, Hillside Hospital, Long Island Jewish Medical Center, Glen Oaks, NY 11004, USA
    Arch Gen Psychiatry 56:241-7. 1999
    ..We examined relapse after response to a first episode of schizophrenia or schizoaffective disorder...
  42. pmc Disseminated tumor cells in prostate cancer patients after radical prostatectomy and without evidence of disease predicts biochemical recurrence
    Todd M Morgan
    Department of Urology, University of Washington School of Medicine, 1959 NE Pacific, BB 1115, Box 356510, Seattle, WA 98195, USA
    Clin Cancer Res 15:677-83. 2009
    ..We sought to determine if epithelial-like cells identified from bone marrow in patients after radical prostatectomy, commonly called disseminated tumor cells (DTC), were associated with biochemical recurrence.
  43. doi Elevated preoperative neutrophil to lymphocyte ratio predicts risk of recurrence following curative resection for stage IIA colon cancer
    Pei Rong Ding
    State Key Laboratory of Oncology in South China, Guangzhou, Guangdong, 510060, People s Republic of China
    Int J Colorectal Dis 25:1427-33. 2010
    ..The purpose of this study was to evaluate whether NLR predicts risk of recurrence in patients with stage IIA colon cancer undergoing curative resection without adjuvant chemotherapy.
  44. doi Socio-economic differences in long-term psychiatric work disability: prospective cohort study of onset, recovery and recurrence
    Marianna Virtanen
    Unit of Expertise in Work and Organizations, Finnish Institute of Occupational Health, Helsinki, Finland
    Occup Environ Med 68:791-8. 2011
    To examine the associations between socio-economic position (SEP) and the onset of psychiatric work disability, return to work and recurrence of disability.
  45. doi Genomic deletion of PTEN is associated with tumor progression and early PSA recurrence in ERG fusion-positive and fusion-negative prostate cancer
    Antje Krohn
    Institute of Pathology, Prostate Cancer Center and Section for Translational Prostate Cancer Research at the Clinic of Urology at University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Am J Pathol 181:401-12. 2012
    ..0001). PTEN deletions were also associated with early prostate-specific antigen recurrence in univariate (P < 0.0001) and multivariate (P = 0.0158) analyses...
  46. pmc Residual Plasmodium falciparum parasitemia in Kenyan children after artemisinin-combination therapy is associated with increased transmission to mosquitoes and parasite recurrence
    Khalid B Beshir
    Department of Immunology and Infection
    J Infect Dis 208:2017-24. 2013
    ..Parasite clearance time after artemisinin-based combination therapy (ACT) may be increasing in Asian and African settings. The association between parasite clearance following ACT and transmissibility is currently unknown...
  47. ncbi Parastomal hernia
    P W G Carne
    Colorectal Unit, Department of Surgery, Christchurch Hospital, Riccarton Avenue, Christchurch, New Zealand
    Br J Surg 90:784-93. 2003
    ..This article reviews the incidence of hernia, the technical factors related to the construction of the stoma that may influence the incidence, and the success of the different methods of repair...
  48. ncbi Primaquine: report from CDC expert meeting on malaria chemoprophylaxis I
    David R Hill
    National Travel Health Network and Centre, London School of Hygiene and Tropical Medicine Mortimer Market Centre, London, England
    Am J Trop Med Hyg 75:402-15. 2006
    ..The adult dose for primary prophylaxis is 30 mg daily begun 1 day before travel and continued for 7 days after return. This review will examine the evidence for these recommendations...
  49. ncbi Evaluation of outcomes with citalopram for depression using measurement-based care in STAR*D: implications for clinical practice
    Madhukar H Trivedi
    Department of Psychiatry, University of Texas Southwestern Medical Center, Exchange Park Express, American General Tower, 6363 Forest Park Rd, Suite 1300, Dallas, TX 75390 9119, USA
    Am J Psychiatry 163:28-40. 2006
    ....
  50. doi Treatment with monoclonal antibodies against Clostridium difficile toxins
    Israel Lowy
    Medarex, Princeton, NJ, USA
    N Engl J Med 362:197-205. 2010
    New therapies are needed to manage the increasing incidence, severity, and high rate of recurrence of Clostridium difficile infection.
  51. ncbi Neuromyelitis optica IgG predicts relapse after longitudinally extensive transverse myelitis
    Brian G Weinshenker
    Department of Neurology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Ann Neurol 59:566-9. 2006
    ..We investigated whether neuromyelitis optica (NMO) IgG seropositivity at the initial presentation of longitudinally extensive transverse myelitis (LETM) predicts relapse of myelitis or development of optic neuritis...
  52. doi Pegylated liposomal Doxorubicin and Carboplatin compared with Paclitaxel and Carboplatin for patients with platinum-sensitive ovarian cancer in late relapse
    Eric Pujade-Lauraine
    University Paris Descartes, Assistance Publique Hopitaux de Paris, Hopital Hotel Dieu, Paris, France
    J Clin Oncol 28:3323-9. 2010
    ....
  53. pmc The natural history of multiple sclerosis: a geographically based study 10: relapses and long-term disability
    Antonio Scalfari
    Imperial College, Division of Neuroscience, London, UK
    Brain 133:1914-29. 2010
    ..The prevention or delay of the progressive phase of the disease is implicated as a key therapeutic target in relapsing-remitting patients...
  54. pmc A modified Delphi approach to standardize low back pain recurrence terminology
    Tasha R Stanton
    The George Institute for Global Health, The University of Sydney, PO Box M201, Missenden Road, Sydney, NSW, 2050, Australia
    Eur Spine J 20:744-52. 2011
    ..The diversity in existing definitions for a 'recurrence of an episode of LBP' and 'recurrent LBP' is an important example...
  55. pmc Temporal and spatial cooperation of Snail1 and Twist1 during epithelial-mesenchymal transition predicts for human breast cancer recurrence
    David D Tran
    Department of Medicine, Washington University Schoolof Medicine, Saint Louis, MO 63088, USA
    Mol Cancer Res 9:1644-57. 2011
    ....
  56. pmc Genotyping of Plasmodium vivax reveals both short and long latency relapse patterns in Kolkata
    Jung Ryong Kim
    Faculty of Tropical Medicine, Department of Clinical Tropical Medicine, Mahidol University, Bangkok, Thailand
    PLoS ONE 7:e39645. 2012
    ..vivax infections relapse frequently at intervals of 3-6 weeks. Defining the epidemiology of these two phenotypes from temporal patterns of illness in endemic areas is difficult or impossible, particularly if they overlap...
  57. ncbi Recurrence after recovery from major depressive disorder during 15 years of observational follow-up
    T I Mueller
    NIMH Collaborative Program on the Psychobiology of Depression Clinical Studies, Brown University School of Medicine, Providence, RI 02906, USA
    Am J Psychiatry 156:1000-6. 1999
    The recurrence of an affective disorder in people who initially recover from major depressive disorder was characterized by using the unique longitudinal prospective follow-up data from the National Institute of Mental Health ..
  58. pmc Antidepressant monotherapy vs sequential pharmacotherapy and mindfulness-based cognitive therapy, or placebo, for relapse prophylaxis in recurrent depression
    Zindel V Segal
    Centre for Addiction and Mental Health, Toronto, ON, Canada
    Arch Gen Psychiatry 67:1256-64. 2010
    ..Mindfulness-based cognitive therapy (MBCT) is a group-based psychosocial intervention designed to enhance self-management of prodromal symptoms associated with depressive relapse...
  59. ncbi Results of initial operation for hyperparathyroidism in patients with multiple endocrine neoplasia type 1
    Dina M Elaraj
    Surgery Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA
    Surgery 134:858-64; discussion 864-5. 2003
    ..with multiple endocrine neoplasia type 1 (MEN1) is characterized by multiglandular disease and a propensity for recurrence after parathyroidectomy (PTx)...
  60. doi Fecal bacteriotherapy for recurrent Clostridium difficile infection
    Johan S Bakken
    St Luke s Hospital, Infectious Disease Associates, 1001 East Superior Street, Suite L201 Duluth, MN 55802, USA
    Anaerobe 15:285-9. 2009
    ....
  61. ncbi Multiple gene expression classifiers from different array platforms predict poor prognosis of colorectal cancer
    Yu Hsin Lin
    Authors Affiliations Cancer Genetics Laboratory and Departments of Biochemistry, Medical and Surgical Sciences, and Pathology, University of Otago
    Clin Cancer Res 13:498-507. 2007
    This study aimed to develop gene classifiers to predict colorectal cancer recurrence. We investigated whether gene classifiers derived from two tumor series using different array platforms could be independently validated by application ..
  62. ncbi Depressive symptoms predict recurrence of atrial fibrillation after cardioversion
    Helmut W Lange
    Kardiologische Praxis am Klinikum Links der Weser, Heart Center Bremen, Bremen, Germany
    J Psychosom Res 63:509-13. 2007
    The aim of this study was to evaluate whether depressive symptoms and the type-D personality are predictive of early recurrence of atrial fibrillation (or atrial flutter; AF) after successful electrical cardioversion (CV).
  63. doi Mindfulness-based cognitive therapy to prevent relapse in recurrent depression
    Willem Kuyken
    Mood Disorders Centre, University of Exeter, Exeter, Devon, UK
    J Consult Clin Psychol 76:966-78. 2008
    ..Relapse/recurrence rates over 15-month follow-ups in MBCT were 47%, compared with 60% in the m-ADM group (hazard ratio = 0...
  64. pmc Gene expression profiling identifies clinically relevant subtypes of prostate cancer
    Jacques Lapointe
    Department of Pathology, Stanford University, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 101:811-6. 2004
    ..High-grade and advanced stage tumors, as well as tumors associated with recurrence, were disproportionately represented among two of the three subtypes, one of which also included most lymph node ..
  65. ncbi Global histone modification patterns predict risk of prostate cancer recurrence
    David B Seligson
    Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles, California 90095, USA
    Nature 435:1262-6. 2005
    ..of samples with similar patterns of modifications identified two disease subtypes with distinct risks of tumour recurrence in patients with low-grade prostate cancer...
  66. ncbi Trastuzumab after adjuvant chemotherapy in HER2-positive breast cancer
    Martine J Piccart-Gebhart
    Medicine Department, Jules Bordet Institute, Blvd de Waterloo 125, 1000 Brussels, Belgium
    N Engl J Med 353:1659-72. 2005
    ..We investigated its efficacy and safety after excision of early-stage breast cancer and completion of chemotherapy...
  67. doi Effect of glatiramer acetate on conversion to clinically definite multiple sclerosis in patients with clinically isolated syndrome (PreCISe study): a randomised, double-blind, placebo-controlled trial
    G Comi
    Institute of Experimental Neurology, Department of Neurology, University Vita Salute, Scientific Institute San Raffaele, Milan, Italy
    Lancet 374:1503-11. 2009
    ..We assessed the efficacy of early treatment with glatiramer acetate in delaying onset of clinically definite multiple sclerosis...
  68. doi Risk and cumulative risk of stroke recurrence: a systematic review and meta-analysis
    Keerthi M Mohan
    King s College London, Division of Health and Social Care Research, and Department of Elderly Care, Guy s and St Thomas NHS Foundation Trust, St Thomas Hospital, 7 Floor Capital House, 42 Weston St, London SE1 3QD, UK
    Stroke 42:1489-94. 2011
    Estimates of risk of stroke recurrence are widely variable and focused on the short- term. A systematic review and meta-analysis was conducted to estimate the pooled cumulative risk of stroke recurrence.
  69. doi Antipsychotic drugs versus placebo for relapse prevention in schizophrenia: a systematic review and meta-analysis
    Stefan Leucht
    Department of Psychiatry and Psychotherapy, Technische Universitat Munchen, Klinikum rechts der Isar, Munich, Germany
    Lancet 379:2063-71. 2012
    ..We aimed to assess the association between such drugs and various outcomes in patients with schizophrenia to resolve controversial issues...
  70. ncbi Long-term mortality and recurrent stroke risk among Chinese stroke patients with predominant intracranial atherosclerosis
    Ka Sing Wong
    Department of Medicine and Therapeutics, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong, SAR
    Stroke 34:2361-6. 2003
    ..The goal of this study was to document the long-term outcome of ischemic stroke patients in a population with predominant intracranial atherosclerosis and risk factors for a recurrent event...
  71. ncbi Mindfulness-based cognitive therapy for depression: replication and exploration of differential relapse prevention effects
    S Helen Ma
    Medical Research Council, Cognition and Brain Sciences Unit, Cambridge, United Kingdom
    J Consult Clin Psychol 72:31-40. 2004
    ..MBCT is an effective and efficient way to prevent relapse/recurrence in recovered depressed patients with 3 or more previous episodes.
  72. ncbi Comparison of warfarin and aspirin for symptomatic intracranial arterial stenosis
    Marc I Chimowitz
    Department of Neurology, School of Medicine, Emory University, Atlanta, USA
    N Engl J Med 352:1305-16. 2005
    ..Atherosclerotic intracranial arterial stenosis is an important cause of stroke. Warfarin is commonly used in preference to aspirin for this disorder, but these therapies have not been compared in a randomized trial...
  73. ncbi JAG1 expression is associated with a basal phenotype and recurrence in lymph node-negative breast cancer
    Michael Reedijk
    Department of Surgical Oncology, University of Toronto, Toronto, ON, Canada, M5G 2M9
    Breast Cancer Res Treat 111:439-48. 2008
    ..As JAG1 is a target of several oncogenic signaling pathways, and is a ligand for Notch, these data provide novel insights into signaling that may contribute to progression of early stage breast cancer...
  74. pmc Plasmodium vivax recurrence following falciparum and mixed species malaria: risk factors and effect of antimalarial kinetics
    Nicholas M Douglas
    Global Health Division, Menzies School of Health Research, Charles Darwin University, Darwin, Australia
    Clin Infect Dis 52:612-20. 2011
    ..Plasmodium vivax malaria commonly follows treatment of falciparum malaria in regions of co-endemicity. This is an important cause of preventable morbidity...
  75. ncbi High recurrence rates of bacterial vaginosis over the course of 12 months after oral metronidazole therapy and factors associated with recurrence
    Catriona S Bradshaw
    Melbourne Sexual Health Centre, The Alfred Hospital, Victoria, Australia
    J Infect Dis 193:1478-86. 2006
    We wished to determine recurrences of bacterial vaginosis (BV) after treatment over the course of 12 months and to establish factors associated with recurrence.
  76. doi Cardiac death and reinfarction after 1 year in the Thrombus Aspiration during Percutaneous coronary intervention in Acute myocardial infarction Study (TAPAS): a 1-year follow-up study
    Pieter J Vlaar
    Department of Cardiology, University Medical Centre Groningen, University of Groningen, Netherlands
    Lancet 371:1915-20. 2008
    ..We aimed to investigate whether the early efficacy of thrombus aspiration seen in TAPAS translated into clinical benefit after 1 year...
  77. ncbi Do oligoclonal bands add information to MRI in first attacks of multiple sclerosis?
    M Tintore
    Unit of Clinical Neuroimmunology, Department of Neurology, Hospital Universitari Vall d Hebron, Universitat Autonoma de Barcelona, Barcelona, Spain
    Neurology 70:1079-83. 2008
    ..To evaluate whether oligoclonal bands (OB) add information to MRI in predicting both a second attack and development of disability in patients with clinically isolated syndromes (CIS)...
  78. ncbi Fatal and non-fatal repetition of self-harm. Systematic review
    David Owens
    Academic Unit of Psychiatry and Behavioural Sciences, University of Leeds, 15 Hyde Terrace, Leeds LS2 9LT, UK
    Br J Psychiatry 181:193-9. 2002
    ..Non-fatal self-harm frequently leads to non-fatal repetition and sometimes to suicide. We need to quantify these two outcomes of self-harm to help us to develop and test effective interventions...
  79. ncbi Problem solving deteriorates following mood challenge in formerly depressed patients with a history of suicidal ideation
    J Mark G Williams
    Department of Psychiatry, University of Oxford, Oxford, United Kingdom
    J Abnorm Psychol 114:421-31. 2005
    ..solutions following mood challenge, consistent with a differential activation account of vulnerability for recurrence of suicidal ideation and behavior...
  80. ncbi The current state of cognitive therapy: a 40-year retrospective
    Aaron T Beck
    Department of Psychiatry, University of Pennsylvania, Philadelphia, 19104, USA
    Arch Gen Psychiatry 62:953-9. 2005
    ..Suggestions for future research and applications are presented...
  81. ncbi Inflammatory changes, recovery and recurrence at COPD exacerbation
    W R Perera
    Academic Unit of Respiratory Medicine, Royal Free and University College Medical School, Rowland Hill Street, Hampstead, London, NW3 2PF, UK
    Eur Respir J 29:527-34. 2007
    ..A high serum C-reactive protein concentration 14 days after an index exacerbation may be used as a predictor of recurrent exacerbations within 50 days...
  82. doi Cognitive--behavioural therapy and family intervention for relapse prevention and symptom reduction in psychosis: randomised controlled trial
    Philippa A Garety
    Department of Psychology, PO77, Institute of Psychiatry, De Crespigny Park, London, SE5 8AF, UK
    Br J Psychiatry 192:412-23. 2008
    ..Family intervention reduces relapse rates in psychosis. Cognitive-behavioural therapy (CBT) improves positive symptoms but effects on relapse rates are not established...
  83. doi Pattern and predictors of soil-transmitted helminth reinfection among aboriginal schoolchildren in rural Peninsular Malaysia
    M Hesham Al-Mekhlafi
    Department of Parasitology, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia
    Acta Trop 107:200-4. 2008
    ..Public health personnel need to re-look at the current control measures and identify innovative and integrated ways in order to reduce STH significantly in the rural communities...
  84. pmc Endoparasite prevalence and recurrence across different age groups of dogs and cats
    Maureen C Gates
    University of Pennsylvania, School of Veterinary Medicine, 3800 Spruce St, Philadelphia, PA 19104, United States
    Vet Parasitol 166:153-8. 2009
    ..Based on notations from the medical history indicating prior parasite infections, estimates of recurrence were generated for each common group of parasites, including Trichuris, Giardia, ascarids, hookworms, ..
  85. pmc Recurrence of sickness absence due to common mental disorders
    Petra C Koopmans
    ArboNed Occupational Health Services Statistics, PO Box 141, 9700 AC, Groningen, The Netherlands
    Int Arch Occup Environ Health 84:193-201. 2011
    Common mental disorders (CMDs) are an important cause of work disability. Although CMDs are known to have high recurrence rates, little is known about the recurrence of sickness absence due to CMDs...
  86. doi Esomeprazole with clopidogrel reduces peptic ulcer recurrence, compared with clopidogrel alone, in patients with atherosclerosis
    Ping I Hsu
    Kaohsiung Veterans General Hospital National Yang Ming University corrected
    Gastroenterology 140:791-8. 2011
    ..We also investigated the effects of esomeprazole on the antiplatelet action of clopidogrel...
  87. doi Aspirin for preventing the recurrence of venous thromboembolism
    Cecilia Becattini
    Division of Internal and Cardiovascular Medicine and Stroke Unit, Department of Internal Medicine, University of Perugia, Perugia, Italy
    N Engl J Med 366:1959-67. 2012
    About 20% of patients with unprovoked venous thromboembolism have a recurrence within 2 years after the withdrawal of oral anticoagulant therapy. Extending anticoagulation prevents recurrences but is associated with increased bleeding...
  88. pmc Fidaxomicin preserves the intestinal microbiome during and after treatment of Clostridium difficile infection (CDI) and reduces both toxin reexpression and recurrence of CDI
    Thomas J Louie
    Department of Medicine, University of Calgary, Foothills Medical Center, 1403 29th St NW, Calgary, Canada
    Clin Infect Dis 55:S132-42. 2012
    ..Similarly, 23% of vancomycin-treated patients (10 of 44) and 11% of fidaxomicin-treated patients (5 of 44) had recurrence of CDI...
  89. doi Risk score for predicting recurrence in patients with ischemic stroke: the Fukuoka stroke risk score for Japanese
    Masahiro Kamouchi
    Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Cerebrovasc Dis 34:351-7. 2012
    Currently, there are only a few risk scores to predict long-term recurrence of ischemic stroke and no risk score has been developed for the Asian population...
  90. doi Prostate cancer recurrence after radical prostatectomy: the role of 3-T diffusion imaging in multi-parametric magnetic resonance imaging
    Valeria Panebianco
    Department of Radiological Sciences, Oncology and Pathology, Sapienza, University of Rome, V le Regina Elena, 324, 00161 Rome, Italy
    Eur Radiol 23:1745-52. 2013
    To validate the role of 3-T diffusion-weighted imaging (DWI) in the detection of local prostate cancer recurrence after radical prostatectomy (RP).
  91. pmc Aurora-A identifies early recurrence and poor prognosis and promises a potential therapeutic target in triple negative breast cancer
    Jie Xu
    State Key Laboratory of Oncology in South China, Cancer Center, Sun Yat Sen University, Guangzhou, China
    PLoS ONE 8:e56919. 2013
    ..025), the proliferation marker Ki-67 (P = 0.001), and the recurrence rate of TNBC patients (P<0.001)...
  92. pmc Epidemiology of recurrences or reinfections of Clostridium difficile-associated diarrhea
    F Barbut
    Department of Microbiology, Hopital Saint Antoine, Assistance Publique Hopitaux de Paris, Paris, France
    J Clin Microbiol 38:2386-8. 2000
    ..The results showed that 48.4% of clinical recurrences were, in fact, reinfections with a different strain of C. difficile. Rates of clinical recurrences could therefore be reduced by implementing strict isolation precautions...
  93. ncbi The effectiveness of personally tailored computer-generated advice letters for smoking cessation
    Ron Borland
    VicHealth Centre for Tobacco Control, Carlton Victoria, Australia
    Addiction 99:369-77. 2004
    ..To assess the effectiveness of a new computer-generated tailored advice programme designed to be used by smokers and recent quitters having problems staying stopped...
  94. ncbi Relapses of Plasmodium vivax infection result from clonal hypnozoites activated at predetermined intervals
    Nanhua Chen
    Australian Army Malaria Institute, Brisbane, Australia
    J Infect Dis 195:934-41. 2007
    ..These findings suggest remarkable regulation of relapse intervals in vivax malaria...
  95. ncbi Determining risk of biochemical recurrence in prostate cancer by immunohistochemical detection of PTEN expression and Akt activation
    Roble Bedolla
    University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA
    Clin Cancer Res 13:3860-7. 2007
    ..of patients who undergo radical prostatectomy as treatment for primary prostate cancer experience biochemical recurrence detected by elevated serum levels of prostate-specific antigen...
  96. ncbi Prevalence, incidence, and recurrence of low back pain in scaffolders during a 3-year follow-up study
    Leo A M Elders
    Department of Public Health, Erasmus MC, University Medical Center Rotterdam, The Netherlands
    Spine (Phila Pa 1976) 29:E101-6. 2004
    ..Prospective cohort study...
  97. doi A trial of combination antimalarial therapies in children from Papua New Guinea
    Harin A Karunajeewa
    School of Medicine and Pharmacology, University of Western Australia, Crawley, WA, Australia
    N Engl J Med 359:2545-57. 2008
    ..Malaria control is difficult where there is intense year-round transmission of multiple plasmodium species, such as in Papua New Guinea...
  98. ncbi Long-term angiographic recurrences after selective endovascular treatment of aneurysms with detachable coils
    Jean Raymond
    Department of Radiology, Centre Hospitalier de l Universite de Montreal, Notre Dame Hospital, 1560 Sherbrooke East, Room M 8203 1, Montreal, Quebec, H2L 4M1, Canada
    Stroke 34:1398-403. 2003
    ..Our aim in this study was to assess the incidence and determining factors of angiographic recurrences after endovascular treatment of aneurysms...
  99. ncbi The epidemiology of venous thromboembolism
    Richard H White
    University of California, Davis, Sacramento, California, USA
    Circulation 107:I4-8. 2003
    ..Despite anticoagulant therapy, VTE recurs frequently in the first few months after the initial event, with a recurrence rate of approximately 7% at 6 months...
  100. pmc Long-term follow-up of a randomized controlled trial of suture versus mesh repair of incisional hernia
    Jacobus W A Burger
    Department of General Surgery, Erasmus University Medical Center, Rotterdam, The Netherlands
    Ann Surg 240:578-83; discussion 583-5. 2004
    The objective of this study was to determine the best treatment of incisional hernia, taking into account recurrence, complications, discomfort, cosmetic result, and patient satisfaction.
  101. doi Ganglionated plexi ablation for longstanding persistent atrial fibrillation
    Evgeny Pokushalov
    Arrhythmia Department, State Research Institute of Circulation Pathology, Novosibirsk, Russia
    Europace 12:342-6. 2010
    ..To study the potential efficacy of ganglionated plexi (GP) ablation in the setting of longstanding persistent atrial fibrillation (AF)...

Research Grants83

  1. High Throughput Genotyping and DNA Sequencing for Studying the Genetic Contributi
    Sonia Dua; Fiscal Year: 2013
    ..to identify such contamination if it occurs, and to correct the source of contamination and prevent its recurrence. m...
  2. Cardiotrophin-Like Cytokine 1, a Candidate Molecule for the FSGS Factor
    Virginia J Savin; Fiscal Year: 2010
    ..Patients with FSGS and rapid progression and/or prior post-transplant recurrence will be studied...
  3. Craig T Morita; Fiscal Year: 2016
    ..Similar treatments today with live BCG help prevent recurrence of bladder cancer...
  4. Clinical , Mechanical and Chemical Evaluation of Amalgam and ART Restorations
    Lilliam Marie Pinzon; Fiscal Year: 2013
    ..dental treatments for large carious lesions with respect to increased restoration longevity and decreased caries recurrence. The reasons for the success of ART have not been clearly established, but it has been suggested that the GIC ..
  5. Scott J Hultgren; Fiscal Year: 2015
    ..direct experimental investigation of common but complex clinical problems associated with more severe UTI and/or recurrence. Aim 1 investigates mechanisms by which superinfection of UPEC leads to the development of chronic/recurrent ..
  6. C. Difficile Outcomes and Effectiveness of Treatment Strategies in SCI
    Charlesnika T Evans; Fiscal Year: 2013
    ..This has resulted in the inclusion of a validation plan to validate the definitions of CDI, failure, recurrence and treatments received (record review of 300 CDI cases and 300 non-CDI cases), dropping the cost analyses from ..
  7. Enhancing radiation and cisplatin HNSCC cell killing by inhibiting mitochondrial
    Lynn Harrison; Fiscal Year: 2013
    ..The overall survival rate is only ~40%, and ~30% of advanced stage disease has locoregional recurrence. Tumor cells living in low oxygen microenvironments are more resistant to radiotherapy...
  8. Biomarkers to Assess Selenium Chemoprevention for NSCLC
    Steven A Belinsky; Fiscal Year: 2012
    ..These findings support gene methylation as a biomarker for assessing response to selenium and predicting cancer recurrence. Second, a preliminary analysis demonstrated a significant association between gene methylation in sputum ..
  9. Chemoprevention of urinary bladder carcinogenesis by flavokawain A
    Xiaolin Zi; Fiscal Year: 2012
    ..about its usefulness in secondary prevention, which clinically will address preventing bladder cancer recurrence and progression. Our microarray analysis has identified a few potential transcriptional targets (i.e...
  10. Rachel M Ceballos; Fiscal Year: 2015
    ..e., fatigue), financial (i.e., job loss), and socio-emotional (i.e., fear of recurrence) burdens of survivorship well beyond completion of primary treatment...
  11. Localization and characterization of the Clostridium difficile biofilm
    Adam Driks; Fiscal Year: 2013
    ..At least 20% of patients successfully treated for CDI symptoms have a recurrence within the next 30 days...
  12. Inhibition of matrix proteases to sensitize medulloblastoma cells to radiation
    Andrei L Gartel; Fiscal Year: 2013
    ..entire CNS (craniospinal irradiation, or CSI) is recommended to prevent the tumor from coming back in this area (recurrence, or relapse)...
  13. Engineering the Brain Immune System for Tumor Therapy
    Maria G Castro; Fiscal Year: 2013
    ..gene therapy eliminates the growing tumor, and induces immunological memory which protects animals from tumor recurrence. Further, we have shown that any adverse side effects are limited, and reversible, with no long term permanent ..
  14. Best Management of Sigmoid Volvulus: a Prospective Randomized Trial
    JONATHAN CHARLES SAMUEL; Fiscal Year: 2013
    ..shorter procedure with faster recovery, lower surgical infection rate, and lower mortality, but a higher disease recurrence rate (compared to single-stage)...
  15. RCT of exercise on aromatase inhibitor side effects in breast cancer survivors
    Melinda L Irwin; Fiscal Year: 2012
    ..trials have demonstrated that using an AI in place of or after tamoxifen reduced the risk of breast cancer recurrence, as compared to treatment with 5 years of tamoxifen...
  16. Androgen Receptor-JunD Complex Inhibitors to Prevent Prostate Cancer Progression
    Hirak S Basu; Fiscal Year: 2012
    ..generation pathway(s) will be more effective than are chemical and/or dietary anti-oxidants in preventing PCa recurrence and progression to CRPCa...
  17. Underserved Men's Understanding of Androgen Deprivation Therapy Related Risks
    Sally L Maliski; Fiscal Year: 2012
    ..being used to treat prostate cancer in the neoadjuvant and adjuvant contexts with radiation therapy (RT), for recurrence following primary treatment with surgery or radiation, or when the prostate cancer is at an advanced stage such ..
  18. Celiac Disease: From Genetic Risk to Disease Development
    Susan L Neuhausen; Fiscal Year: 2009
    ..No pharmacological treatment is available. Although treatment with a gluten-free diet will improve symptoms, recurrence of symptoms and complications may occur after minor dietary indiscretions...
  19. Web-based Patient-Reported Outcomes (PRO) System for Breast Cancer Survivors
    JOHN CHRISTOPHER WEISS; Fiscal Year: 2010
    ..Proactive monitoring of survivor symptoms (such as those symptoms indicating possible recurrence or addressable treatment-related side effects) and quality of life (QOL) are not commonly addressed during ..
  20. Steven D Goodman; Fiscal Year: 2016
    ..Significantly, we've come to appreciate the role that biofilms play in the chronicity and recurrence of NTHI-induced OM...
  21. microRNAs as novel biomarkers for management of breast cancer
    LORENZO SEMPERE; Fiscal Year: 2012
    ..utility of identified signatures to predict treatment response in dif- ferent adjuvant therapy settings using recurrence-free survival as endpoint marker and in a neoadjuvant therapy setting using pathological complete response as ..
  22. IVAN B YANACHKOV; Fiscal Year: 2015
    ..Despite the recent advances in development of new types of antithrombotics and because of the high mortality and recurrence rate and major bleeding events among acute coronary syndrome patients, there is a significant need for new ..
  23. Regulation of Ovarian Cancer Multidrug Resistance by MAP Kinases
    Scott T Eblen; Fiscal Year: 2013
    Many ovarian tumors respond to initial drug therapy, but become refractory to drug treatment upon recurrence. Therefore, defining the mechanisms of drug resistance is important for existing and new cancer therapies...
  24. Detection of Prostate Cancer Genomic Signatures in Blood
    Amin I Kassis; Fiscal Year: 2010
    ..that will (i) be used for the routine detection/diagnosis of PC, and (ii) be employed to identify disease recurrence. Consequently, we expect the blood test to have an unprecedentedly high impact on, and contribute significantly ..
  25. A Novel Target for the Treatment of Endometriosis
    Paul D Crowe; Fiscal Year: 2011
    ..Laparoscopic surgery provides temporary pain relief, but the recurrence rate is conservatively estimated to be 50% after five years. The benefits of drug treatment are also limited...
  26. Identification of Biomarkers for Early Detection of Renal Cell Carcinoma
    Othon Iliopoulos; Fiscal Year: 2012
    ..for local and/or systemic relapse and without clinically obvious disease to get additional therapy that prevents recurrence of their disease...
  27. Khalid A Shah; Fiscal Year: 2016
    ..However, recurrence rates of GBM and the associated patient mortality are nearly 100%...
  28. Adonis K Hijaz; Fiscal Year: 2014
    ..Impaired recovery significantly increases the chance of recurrence of SUI over time...
  29. Optically-Guided Bladder Biopsy Using Polarized Elastic Scattering Spectroscopy
    FREDERICK GEORGE BARGOOT; Fiscal Year: 2010
    ..This is followed by biopsy and surgical intervention. The recurrence rate for bladder cancer after surgery is an onerous 50-70%...
  30. Dawn Hershman; Fiscal Year: 2015
    ..have been shown to be superior to tamoxifen in improving disease free survival, decreasing distant and local recurrence rates and decreasing incidence of contra-lateral breast cancer in women with early stage hormone receptor ..
  31. Bruce R Blazar; Fiscal Year: 2016
    ..immune system recovery post-BMT, predisposing the recipient to succumb to infections with pathogens and tumor recurrence. LN organogenesis is dependent upon lymphotoxin-[unreadable]1[unreadable]2, expressed on activated T-cells, B-..
  32. TARGETING FLIP FOR PROSTATE CANCER PREVENTION
    Addanki P Kumar; Fiscal Year: 2012
    ..Although androgen ablation inhibits prostate cancer growth temporarily, eventual recurrence of androgen independent disease is the major cause of prostate cancer related deaths in men...
  33. Optimal Prevention and Control of Periodontal Disease: The Periodontal Pocket Irr
    Thomas E Van Dyke; Fiscal Year: 2011
    ..Most patients are unable to maintain adequate oral hygiene to prevent recurrence of their disease leading to additional health care expense. The SBI project addresses this subject...
  34. Margot S Damaser; Fiscal Year: 2014
    ..of potential primary candidates for an intervention that would both treat their current incontinence and prevent recurrence of incontinence later in life...
  35. Harvey J Murff; Fiscal Year: 2014
    ..that might influence the efficacy of fish oil supplementation in order to conduct a more definitive adenoma recurrence trial using marine-derived n-3 PUFAs...
  36. Breast Carcinoma in situ: Predicting Risk and Outcomes
    Amy Trentham-Dietz; Fiscal Year: 2013
    ..The long-term goal of this project is to reduce the public health impact of BCIS by quantifying both contextual and personal risk factors for the development of BCIS and the recurrence of breast cancer after a BCIS diagnosis.
  37. Identification of small molecule inhibitors of protein disulfide isomerase
    ROBERT C FLAUMENHAFT; Fiscal Year: 2012
    ..The high rate of recurrence following heart attacks and strokes despite current therapies indicates a need to identify new targets with ..
  38. Immunomodulatory Mechanisms of Withafarin A in Her-2 neu breast cancer
    ANNALISE ROXANNE SMITH; Fiscal Year: 2013
    ..The benefit of such a strategy would impact the frequent recurrence of metastases of dormant tumor cells after conventional chemotherapy regimens that can cause tumor relapse and ..
  39. NESTOR RAUL GONZALEZ; Fiscal Year: 2016
    ..medical problem, carrying one of the highest rates of recurrent stroke despite medical therapy, with annual recurrence rates for ischemic stroke reported in the SAMMPRIS Trial as high as 12.2% in the intensive medical therapy arm...
  40. Adiposity and Outcomes of Clinically Localized Prostate Cancer
    Vincent L Freeman; Fiscal Year: 2013
    ..It will also shed light on ways to prevent prostate cancer recurrence that may involve new or existing medicines or lifestyle changes.
  41. PA-50/PA-41 antitoxin antibody therapy for C. difficile infection
    William C Olson; Fiscal Year: 2012
    ..First-generation antitoxin mAbs have shown clinical activity in preventing recurrence of CDI but not in treating active disease...
  42. The Role of CYP1B1 in the Recurrence of Head and Neck Cancer
    Ekaterina G Shatalova; Fiscal Year: 2013
    ..Mortality among HNSCC patients is very high, often due to recurrence of primary disease. Major risk factors for HNSCC include tobacco and alcohol use...
  43. Slow cycling brain tumor cancer stem cells
    BRENT REYNOLDS; Fiscal Year: 2010
    ..Although a transient response to therapy is often observed, tumour recurrence is almost inevitable and usually occurs within tissue that has received intensive cytotoxic therapy, suggesting ..
  44. Role of the Sex Hormones and Insulin/IGF-Axes in Endometrial Cancer Recurrence
    Howard D Strickler; Fiscal Year: 2012
    ..However, little is known regarding the biologic factors that underlie endometrial cancer recurrence. We reason that many of the same risk factors associated with the initial development of endometrial cancer may ..
  45. Darell D Bigner; Fiscal Year: 2016
    ..Less than half of patients treated with these two agents respond. Recurrence after treatment is almost universal and median survival is 15 to 18 months with few long-term survivors...
  46. Douglas L Feinstein; Fiscal Year: 2016
    ..be treated it requires long term supplementation with Vitamin K, and any interruption in treatment can lead to recurrence of symptoms...
  47. A novel therapy for HER2 positive hormone refractory breast cancer
    Anne W Hamburger; Fiscal Year: 2010
    ..PUBLIC HEALTH RELEVANCE: Despite numerous advances in therapies for breast cancer in recent years, recurrence and mortality remain high...
  48. Kaustubh Datta; Fiscal Year: 2014
    ..that by protecting the prostate cancer cells from stress-induced apoptosis, VEGF-C promotes prostate cancer recurrence and metastasis...
  49. Stacey L Halum; Fiscal Year: 2014
    ..the model may ultimately be applied to other areas of laryngology such as controlling respiratory papillomatosis recurrence, providing adjuvant therapy for laryngeal squamous cell carcinoma, or augmenting vocal folds in presbylaryngis...
  50. DENNIS J MCGINTY; Fiscal Year: 2014
    ..Insomnia, particularly sleep fragmentation, predicts subsequent major depressive disorder (MDD) and recurrence of MDD in remitted patients...
  51. Ann Richmond; Fiscal Year: 2016
    ..We hypothesize that perisurgical delivery of entraining chemokines to cancer patients may reduce recurrence and metastasis...
  52. BRCA1 and progesterone receptors in breast cancer
    Eva Y Lee; Fiscal Year: 2013
    ..Furthermore, we plan to explore the potential of CDB-2914 in blocking tumor recurrence after chemotherapeutic treatment...
  53. Murine Models for Mantle Cell Lymphoma: The role of tumor initiating cells (TIC)
    Richard J Ford; Fiscal Year: 2010
    ..of putative MCL/ TIC in the DTG/MCL-BV model, contributes to the initiation, tumor maintenance, and possibly recurrence of the DTG lymphoma...
  54. Treating cutaneous leishmaniasis by radio-frequency induced heat (RFH) therapy
    Abhay R Satoskar; Fiscal Year: 2012
    ..Leishmania species that are difficult to treat with conventional drugs, and to determine the risk of disease recurrence (if any) in patients living in Leishmania endemic regions...
  55. Targeted cell therapy for the treatment of ventricular tachycardia
    KENNETH LAURITA; Fiscal Year: 2010
    ..RF) catheter ablation can cure arrhythmias associated with MI;however, many patients are not suitable and the recurrence rate is high. Consequently, SCD remains a major unresolved public health problem...
  56. Hyeong Reh Choi Kim; Fiscal Year: 2014
    ..is well documented that HPV-positive oropharyngeal cancer patients experience significantly lower locoregional recurrence and significantly higher overall survival in comparison with HPV-negative patients, especially among those who ..
  57. Reducing Breast Cancer Recurrence with Weight Loss: A Vanguard Trial
    Cheryl L Rock; Fiscal Year: 2013
    ..there has never been a clinical trial to determine whether weight loss and maintenance of that loss reduces recurrence risk...
  58. JOHN P O'BRYAN; Fiscal Year: 2014
    ..is extremely rare as the remaining cancer cells inevitably infiltrate the normal brain tissue and cause tumor recurrence. Local invasion remains an important cause of morbidity and mortality from brain tumors...
  59. Paul Nghiem; Fiscal Year: 2015
    ..to further characterize anti-T-Ag antibodies and to test their clinical utility as a specific biomarker for MCC recurrence. We have also found that cell-mediated immunity (intratumoral CD8+ T cell infiltration) is associated with ..
  60. EXTRACELLULAR MATRIX IN INFLAMMATORY BOWEL DISEASE
    ALAN DAVID LEVINE; Fiscal Year: 2010
    ..and proteoglycans known as the extracellular matrix (ECM), we propose that the chronicity, exacerbation, and recurrence of IBD are multifactorial, involving a process by which the intermingled pathogenic T cells adversely affects ..
  61. Chemoprevention of Head &Neck Cancer Using Controlled Release Polymers
    Susan R Mallery; Fiscal Year: 2013
    ..treatment failures drive HNSCC morbidity and mortality, identification of effective treatments to prevent local recurrence has the potential to dramatically improve patient survival...
  62. Dysregulation of the Tumor Microenvironment in Hepatocellular Carcinoma
    Lewis R Roberts; Fiscal Year: 2010
    ..We have shown that the recently identified heparin-degrading endosulfatase, SULF2, is associated with tumor recurrence and worse prognosis of human HCC and promotes the growth of HCC xenografts in nude mice;in contrast, the related ..
  63. Gene Networks for Prostate Cancer Progression
    Leif Peterson; Fiscal Year: 2005
    ..FGFR2-inducible mice, TRAMP mice, and in human prostate tumors for recurrent patients with early and late PSA recurrence times. Specific aim one: identify putative targets of the FGFR1 and FGFR2 pathways in mouse prostate tissue...
  64. Oral H. pylori Prevalence in Intellectually/Developmentally Disabled Adults
    Catherine Binkley; Fiscal Year: 2009
    ..pylori infection at approximately twice the rate of the general population and experience recurrence at a seven-fold higher rate, contributing to increased mortality due to gastric cancer...
  65. Combined raman spectroscopy-optical tomagraphy for complete diagnosis of skin can
    Anita Mahadevan Jansen; Fiscal Year: 2009
    ..the skin cancer margins prior to and during the surgery, and allow treated patients to be monitored for recurrence. In this proposal we present a method that combines Optical Coherence Tomography (OCT), an imaging technique ..
  66. PREVENTION OF ULCER HEMORRHAGE BY H PYLORI ERADICATION
    Dennis Jensen; Fiscal Year: 2000
    This is a multicenter, double-blind, randomized comparison of two different medical treatments to prevent recurrence of duodenal ulcer (DU) and gastric ulcer (GU) bleeding...
  67. Randomized Trial/Reduce Recurrence/Bacterial Vaginosis
    King Holmes; Fiscal Year: 2004
    ..treatment of women with BV using metronidazole successfully eliminates symptoms and signs of vaginal discharge, recurrence rates are high...
  68. Anti-Idiotype Therapy of Human B Cell Malignancy
    Ronald Levy; Fiscal Year: 2007
    ..Most of these patients are alive and are still free of lymphoma. The most important data about disease recurrence, overall survival and the relationship of these events to vaccine maneuvers and immune responses is yet to be ..
  69. CAD-CAM TECHNOLOGY FOR DIABETIC FOOTWEAR
    JOSEPH L LOOMIS; Fiscal Year: 2010
    ..blinded clinical trial we will now test the clinical efficacy of TrueContour" insoles in preventing foot ulcer recurrence in patients with previous and now healed plantar neuropathic foot ulcers...
  70. Flaxseed vs. aromatase inhibitors: breast tumor characteristics and prognosis
    Susan McCann; Fiscal Year: 2009
    ..by applicant): Although the 10 year survival rate for women with early stage breast cancer is very good, distant recurrence is still a serious concern, especially for estrogen receptor positive women...
  71. RANDOMIZED AMIODARONE THERAPY FOR SURVIVORS OF VF
    Leon Greene; Fiscal Year: 1991
    ..Resuscitated survivors of ventricular fibrillation have a high risk of recurrence of ventricullar fibrillation...
  72. MCAV in Organ-Confined Bladder CA based on p53 Status
    Richard Cote; Fiscal Year: 2006
    ..We have shown that (1) adjuvant chemotherapy prolongs the recurrence free interval in a group of patients with invasive TCC at high risk for recurrence and that (2) detection of p53 ..
  73. TISSUE AND SERUM INDICATORS OF LUNG CANCER RECURRENCE
    David Harpole; Fiscal Year: 2000
    ..is to define tissue and serum tumor markers in patients with stage I NSCLC which predict for early cancer recurrence. Pathologic stage I NSCLC was chosen for study to eliminate the significant influence of positive lymph nodes ..
  74. Molecular Characterization of Stage I Lung Cancer
    Ming You; Fiscal Year: 2010
    ..It is critical to develop molecular predictors for recurrence. In a recent study, we applied a meta-analysis of data sets from seven different microarray studies on lung ..
  75. Beta Camera and Laparoscopic Probe for Surgical Cancer Removal.
    FARHAD DAGHIGHIAN; Fiscal Year: 2007
    ..In breast cancer, for example, there is a 20% recurrence rate after breast-conserving surgery (lumpectomy) due to missed margins...
  76. DECREASING SEVERITY OF RECURRENT HEPATITIS C IN LIVER
    Lakshmi Gaur; Fiscal Year: 1999
    Based on observations we have recently made, there is evidence that the recurrence of hepatitis C virus (HCV)-induced liver disease in transplanted livers may be reduced by the careful selection of the donor...
  77. RANDOMIZED ADJUVANT THERAPY OF HEAD AND NECK CANCER
    Dong Shin; Fiscal Year: 2001
    ..local therapy has not been established, although the survival rate is low because of the high incidence of recurrence and second primary tumor development...
  78. Colon Cancer Prevention Program Project Grant
    M Lance; Fiscal Year: 2009
    ..To accomplish this goal, we seek to develop highly effective intervention strategies to prevent the recurrence of sporadic adenomatous polyps, and to define the fundamental epidemiologic, epigenetic and genetic mechanisms ..
  79. Calcium/Vitamin D, Biomarkers & Colon Polyp Prevention
    Roberd Bostick; Fiscal Year: 2009
    ..efficacy of supplemental calcium 1,200 mg/day and/or vitamin D3 1,000 IU/day against sporadic colorectal adenoma recurrence. The biomarker study tests whether these interventions can also normalize a panel of immunohistochemically (IHC) ..
  80. COGNITIVE THERAPY FOR HIGH RISK & REFRACTORY DEPRESSION
    Robin Jarrett; Fiscal Year: 2003
    ..Relapse/recurrence (DSM IF MDD) is assessed by a blind evaluator using the LIFE at 4, 8, 12, and 24 months post-acute phase CT and ..
  81. REPRODUCTIVE/CONTRACEPTIVE RISK FACTORS & ENDOMETRIOSIS
    Victoria Holt; Fiscal Year: 2005
    ..Knowledge of risk or protective factors for recurrence is of great importance, therefore, yet the effect of patient characteristics and behaviors on symptom recurrence ..
  82. Molecular profiles of colorectal adenomas by array CGH
    Galen Hostetter; Fiscal Year: 2009
    ..of a hypothesis-driven research plan to analyze genomic alteration patterns associated with colorectal adenoma recurrence and high risk adenomas. My primary mentor is Dr...
  83. Recurrence of T1D in Pancreas Transplantation
    George Burke; Fiscal Year: 2009
    ..and without evidence of rejection were studied in detail and were found to have the cardinal features of recurrence of autoimmunity, including autoantibodies, insulitis and the presence of autoreactive T cells in peripheral ..