disease susceptibility

Summary

Summary: A constitution or condition of the body which makes the tissues react in special ways to certain extrinsic stimuli and thus tends to make the individual more than usually susceptible to certain diseases.

Top Publications

  1. pmc Differential DNA methylation in purified human blood cells: implications for cell lineage and studies on disease susceptibility
    Lovisa E Reinius
    Department of Biosciences and Nutrition, Karolinska Institutet, Stockholm, Sweden
    PLoS ONE 7:e41361. 2012
  2. ncbi Environmental epigenomics and disease susceptibility
    Randy L Jirtle
    Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Nat Rev Genet 8:253-62. 2007
  3. pmc Interaction between ERAP1 and HLA-B27 in ankylosing spondylitis implicates peptide handling in the mechanism for HLA-B27 in disease susceptibility
    David M Evans
    Medical Research Council MRC Centre for Causal Analyses in Translational Epidemiology, School of Social and Community Medicine, University of Bristol, Bristol, UK
    Nat Genet 43:761-7. 2011
  4. ncbi Genetic variation in Toll-like receptors and disease susceptibility
    Mihai G Netea
    Department of Internal Medicine, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    Nat Immunol 13:535-42. 2012
  5. ncbi The cytoplasmic body component TRIM5alpha restricts HIV-1 infection in Old World monkeys
    Matthew Stremlau
    Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 427:848-53. 2004
  6. ncbi Dual infection with HIV and malaria fuels the spread of both diseases in sub-Saharan Africa
    Laith J Abu-Raddad
    Statistical Center for HIV Aids Research and Prevention, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Science 314:1603-6. 2006
  7. ncbi Genome-wide association studies identify IL23R-IL12RB2 and IL10 as Behçet's disease susceptibility loci
    Nobuhisa Mizuki
    Department of Ophthalmology and Visual Science, Yokohama City University, Yokohama, Kanagawa, Japan
    Nat Genet 42:703-6. 2010
  8. pmc Human TRAF3 adaptor molecule deficiency leads to impaired Toll-like receptor 3 response and susceptibility to herpes simplex encephalitis
    Rebeca Pérez de Diego
    Laboratory of Human Genetics of Infectious Diseases, Necker Branch, Inserm U980, Necker Medical School, Paris, France
    Immunity 33:400-11. 2010
  9. ncbi Mice with a disrupted IFN-gamma gene are susceptible to the induction of experimental autoimmune encephalomyelitis (EAE)
    I A Ferber
    Department of Medicine, Stanford University Medical School, CA 94305, USA
    J Immunol 156:5-7. 1996
  10. ncbi Environmental factors and multiple sclerosis
    George C Ebers
    University Department of Clinical Neurology, Level 3, West Wing, John Radcliffe Hospital, Oxford OX3 9DU, UK
    Lancet Neurol 7:268-77. 2008

Detail Information

Publications288 found, 100 shown here

  1. pmc Differential DNA methylation in purified human blood cells: implications for cell lineage and studies on disease susceptibility
    Lovisa E Reinius
    Department of Biosciences and Nutrition, Karolinska Institutet, Stockholm, Sweden
    PLoS ONE 7:e41361. 2012
    ....
  2. ncbi Environmental epigenomics and disease susceptibility
    Randy L Jirtle
    Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Nat Rev Genet 8:253-62. 2007
    ..An increasing body of evidence from animal studies supports the role of environmental epigenetics in disease susceptibility. Furthermore, recent studies have demonstrated for the first time that heritable environmentally induced ..
  3. pmc Interaction between ERAP1 and HLA-B27 in ankylosing spondylitis implicates peptide handling in the mechanism for HLA-B27 in disease susceptibility
    David M Evans
    Medical Research Council MRC Centre for Causal Analyses in Translational Epidemiology, School of Social and Community Medicine, University of Bristol, Bristol, UK
    Nat Genet 43:761-7. 2011
    ..These findings provide strong evidence that HLA-B27 operates in ankylosing spondylitis through a mechanism involving aberrant processing of antigenic peptides...
  4. ncbi Genetic variation in Toll-like receptors and disease susceptibility
    Mihai G Netea
    Department of Internal Medicine, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    Nat Immunol 13:535-42. 2012
    ..This interaction explains the differences in the effect of TLR polymorphisms on susceptibility to infection and autoimmune disease in various populations...
  5. ncbi The cytoplasmic body component TRIM5alpha restricts HIV-1 infection in Old World monkeys
    Matthew Stremlau
    Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 427:848-53. 2004
    ..Our studies identify TRIM5alpha as a species-specific mediator of innate cellular resistance to HIV-1 and reveal host cell components that modulate the uncoating of a retroviral capsid...
  6. ncbi Dual infection with HIV and malaria fuels the spread of both diseases in sub-Saharan Africa
    Laith J Abu-Raddad
    Statistical Center for HIV Aids Research and Prevention, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Science 314:1603-6. 2006
    ..Hence, transient and repeated increases in HIV viral load resulting from recurrent co-infection with malaria may be an important factor in promoting the spread of HIV in sub-Saharan Africa...
  7. ncbi Genome-wide association studies identify IL23R-IL12RB2 and IL10 as Behçet's disease susceptibility loci
    Nobuhisa Mizuki
    Department of Ophthalmology and Visual Science, Yokohama City University, Yokohama, Kanagawa, Japan
    Nat Genet 42:703-6. 2010
    ..9 x 10(-11), odds ratio = 1.35; rs1800871 in IL10, P = 1.0 x 10(-14), odds ratio = 1.45)...
  8. pmc Human TRAF3 adaptor molecule deficiency leads to impaired Toll-like receptor 3 response and susceptibility to herpes simplex encephalitis
    Rebeca Pérez de Diego
    Laboratory of Human Genetics of Infectious Diseases, Necker Branch, Inserm U980, Necker Medical School, Paris, France
    Immunity 33:400-11. 2010
    ..Thus, TLR3-mediated immunity against primary infection by HSV-1 in the central nervous system is critically dependent on TRAF3...
  9. ncbi Mice with a disrupted IFN-gamma gene are susceptible to the induction of experimental autoimmune encephalomyelitis (EAE)
    I A Ferber
    Department of Medicine, Stanford University Medical School, CA 94305, USA
    J Immunol 156:5-7. 1996
    ..We conclude that the presence of IFN-gamma is not crucial to the induction or the clinical course of EAE...
  10. ncbi Environmental factors and multiple sclerosis
    George C Ebers
    University Department of Clinical Neurology, Level 3, West Wing, John Radcliffe Hospital, Oxford OX3 9DU, UK
    Lancet Neurol 7:268-77. 2008
    ..Although these could be independent additive risk factors, it seems more likely that susceptibility is mediated by direct interactions between the environment and genes...
  11. pmc Endocrine disrupting chemicals and disease susceptibility
    Thaddeus T Schug
    National Institute of Environmental Health Sciences, Division of Extramural Research and Training, Cellular, Organ and Systems Pathobiology Branch, Research Triangle Park, NC 27709, USA
    J Steroid Biochem Mol Biol 127:204-15. 2011
    ..during early stages of development can disrupt normal patterns of development and thus dramatically alter disease susceptibility later in life...
  12. ncbi Pseudomonas syringae pv. tomato DC3000: a model pathogen for probing disease susceptibility and hormone signaling in plants
    Xiu Fang Xin
    Department of Energy Plant Research Laboratory, Michigan State University, East Lansing, Michigan 48824, USA
    Annu Rev Phytopathol 51:473-98. 2013
    ..how a bacterial pathogen employs type III effectors to suppress plant immune responses and promote disease susceptibility but has also facilitated the discovery of the immune function of stomata and key components of JA ..
  13. ncbi High susceptibility to repeated, low-dose, vaginal SHIV exposure late in the luteal phase of the menstrual cycle of pigtail macaques
    Sundaram A Vishwanathan
    Division of HIV AIDS Prevention, CDC, Atlanta, GA 30329, USA
    J Acquir Immune Defic Syndr 57:261-4. 2011
    ..Our data support the findings of higher susceptibility to HIV in women during progesterone-dominated periods including pregnancy and contraceptive use...
  14. pmc Anopheles gambiae immune responses to human and rodent Plasmodium parasite species
    Yuemei Dong
    W Harry Feinstone Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, USA
    PLoS Pathog 2:e52. 2006
    ..Furthermore, our data indicate that the mosquito is capable of sensing infected blood constituents in the absence of invading ookinetes, thereby inducing anti-Plasmodium immune responses...
  15. pmc Th17 cells and IL-17 receptor signaling are essential for mucosal host defense against oral candidiasis
    Heather R Conti
    Department of Oral Biology, School of Dental Medicine, State University of New York, Buffalo, NY 14201, USA
    J Exp Med 206:299-311. 2009
    ..Thus, the Th17 lineage, acting largely through IL-17, confers the dominant response to oral candidiasis through neutrophils and antimicrobial factors...
  16. ncbi Mice devoid of PrP are resistant to scrapie
    H Bueler
    Institut für Molekularbiologie I, Universitat Zurich, Switzerland
    Cell 73:1339-47. 1993
    ..These experiments show that PrPC, possibly at close to normal levels, is required for the usual susceptibility to scrapie and that lack of homology between incoming prions and the host's PrP genes retards disease...
  17. pmc No strong relationship between mannan binding lectin or plasma ficolins and chemotherapy-related infections
    D C Kilpatrick
    SNBTS National Science Laboratory, University of Edinburgh, UK
    Clin Exp Immunol 134:279-84. 2003
    ..These results cast doubt on the potential value of MBL replacement therapy in this clinical context...
  18. ncbi Functional role of type I and type II interferons in antiviral defense
    U Muller
    Institute of Molecular Biology I, University of Zurich, Switzerland
    Science 264:1918-21. 1994
    ..Comparison of mice lacking either type I or type II IFN receptors showed that, at least in response to some viruses, both IFN systems are essential for antiviral defense and are functionally nonredundant...
  19. ncbi Disease spread, susceptibility and infection intensity: vicious circles?
    Pablo M Beldomenico
    Facultad de Ciencias Veterinarias, Universidad Nacional del Litoral, RP Kreder 2805, 3080 Esperanza, Santa Fe, Argentina
    Trends Ecol Evol 25:21-7. 2010
    ..We argue that this potential synergy between host susceptibility and infection should be more widely acknowledged in disease ecology research...
  20. ncbi Epidemic threshold for the susceptible-infectious-susceptible model on random networks
    Roni Parshani
    Minerva Center and Department of Physics, Bar Ilan University, Ramat Gan, Israel
    Phys Rev Lett 104:258701. 2010
    ....
  21. ncbi Susceptibility factors to ozone-related mortality: a population-based case-crossover analysis
    Massimo Stafoggia
    Department of Epidemiology, Rome E Health Authority, Rome, Italy
    Am J Respir Crit Care Med 182:376-84. 2010
    ..Acute effects of ozone on mortality have been extensively documented in clinical and epidemiological research. However, only a few studies have focused on subgroups of the population especially vulnerable to these effects...
  22. ncbi Deficiency of mannose-binding lectin-associated serine protease-2 associated with increased risk of fever and neutropenia in pediatric cancer patients
    Luregn J Schlapbach
    Department of Pediatrics, University of Bern, Bern, Switzerland
    Pediatr Infect Dis J 26:989-94. 2007
    ..The aim of the present study was to determine whether children with cancer and MASP-2 deficiency develop more frequent or more severe episodes of fever and severe chemotherapy-induced neutropenia (FN)...
  23. ncbi Sepsis mortality prediction based on predisposition, infection and response
    Rui P Moreno
    Unidade de Cuidados Intensivos Polivalente, Hospital de St António dos Capuchos, Centro Hospitalar de Lisboa Central E P E, 1150 069 Lisbon, Portugal
    Intensive Care Med 34:496-504. 2008
    ....
  24. ncbi Dual role for nitric oxide in paracoccidioidomycosis: essential for resistance, but overproduction associated with susceptibility
    Flavia R F Nascimento
    Departamento de Imunologia, Instituto de Ciencias Biomedicas, Universidade de Sao Paulo, Sao Paulo, Brazil
    J Immunol 168:4593-600. 2002
    ..We conclude that NOS2-derived NO is essential for resistance to paracoccidioidomycosis, but overproduction is associated with susceptibility...
  25. ncbi Immunization is ineffective at preventing infection and mortality due to the amphibian chytrid fungus Batrachochytrium dendrobatidis
    Mary J Stice
    Department of Integrative Biology, University of California Berkeley, 3060 VLSB MC3140, Berkeley, California 94720, USA
    J Wildl Dis 46:70-7. 2010
    ....
  26. ncbi The macrophage-inducible C-type lectin, mincle, is an essential component of the innate immune response to Candida albicans
    Christine A Wells
    National Centre for Adult Stem Cell Research, Eskitis Institute for Cell and Molecular Therapies, Griffith University, Brisbane, Queensland, Australia
    J Immunol 180:7404-13. 2008
    ..In addition, mice lacking Mincle showed a significantly increased susceptibility to systemic candidiasis. Thus, Mincle plays a novel and nonredundant role in the induction of inflammatory signaling in response to C. albicans infection...
  27. pmc A functional Toll-like receptor 3 gene (TLR3) may be a risk factor for tick-borne encephalitis virus (TBEV) infection
    Elin Kindberg
    Division of Molecular Virology, Medical Faculty, University of Linkoping, Linkoping, Sweden
    J Infect Dis 203:523-8. 2011
    ..A mutation in the chemokine receptor 5 gene has been associated with increased risk of TBE but explains only a limited number of cases. Investigations of further risk factors are needed...
  28. pmc Genetics of host response to Leishmania tropica in mice - different control of skin pathology, chemokine reaction, and invasion into spleen and liver
    Tetyana Kobets
    Laboratory of Molecular and Cellular Immunology, Institute of Molecular Genetics, Academy of Sciences of the Czech Republic, Prague, Czech Republic
    PLoS Negl Trop Dis 6:e1667. 2012
    ..The relationship between the host genotype and disease manifestations is poorly understood because there were no suitable animal models...
  29. pmc Pre-eclampsia and offspring cardiovascular health: mechanistic insights from experimental studies
    Esther F Davis
    Oxford Cardiovascular Clinical Research Facility, Department of Cardiovascular Medicine, University of Oxford, Oxford, UK
    Clin Sci (Lond) 123:53-72. 2012
    ....
  30. pmc Human skin pigmentation, migration and disease susceptibility
    Nina G Jablonski
    Department of Anthropology, The Pennsylvania State University, University Park, PA 16802, USA
    Philos Trans R Soc Lond B Biol Sci 367:785-92. 2012
    ..Low UVB levels and vitamin D deficiencies produced by changes in location and lifestyle pose some of the most serious disease risks of the twenty-first century...
  31. pmc A novel role for APOBEC3: susceptibility to sexual transmission of murine acquired immunodeficiency virus (mAIDS) is aggravated in APOBEC3 deficient mice
    Philip H Jones
    Department of Microbiology, Carver College of Medicine, University of Iowa, 51 Newton Road, Iowa City, IA 52242 1109, USA
    Retrovirology 9:50. 2012
    ..In this present study, we used APOBEC3 knockout mice and their wild type counterpart to query the role of APOBEC3 in sexual transmission of LP-BM5 MLV - the etiological agent of murine AIDs (mAIDs)...
  32. pmc The MTAP-CDKN2A locus confers susceptibility to a naturally occurring canine cancer
    Abigail L Shearin
    Cancer Genetics Branch, National Human Genome Research Institute, NIH, Bethesda, MD 20892, USA
    Cancer Epidemiol Biomarkers Prev 21:1019-27. 2012
    ..Cancers that have been difficult to study in human families or populations are of particular interest. Histiocytic sarcoma is a rare and poorly understood neoplasm in humans that occurs in 15% to 25% of Bernese Mountain Dogs (BMD)...
  33. ncbi Strain-specific colitis susceptibility in IL10-deficient mice depends on complex gut microbiota-host interactions
    Gwen Büchler
    Institute for Laboratory Animal Science and Central Animal Facility, Hannover Medical School, Hannover, Germany
    Inflamm Bowel Dis 18:943-54. 2012
    ..The aim of this study was to determine the impact of microbiota on this differential colitis susceptibility using a Helicobacter hepaticus infection model...
  34. pmc The mitochondrial paradigm for cardiovascular disease susceptibility and cellular function: a complementary concept to Mendelian genetics
    David M Krzywanski
    Division of Molecular and Cellular Pathology, Department of Pathology, The University of Alabama at Birmingham, Birmingham, AL, USA
    Lab Invest 91:1122-35. 2011
    ..studies will serve as the initial steps for addressing the provocative concept that contemporary human disease susceptibility is the result of selection events for mitochondrial function that increased chances for prehistoric human ..
  35. ncbi Antisense downregulation of polyphenol oxidase results in enhanced disease susceptibility
    Piyada Thipyapong
    Department of Plant Breeding, Cornell University, 252 Emerson Hall, Ithaca, NY 14853 1901, USA
    Planta 220:105-17. 2004
    ..While PPO B inducibility was the same in both compatible and incompatible interactions, PPO D, E and F were induced to higher levels and with different expression patterns in incompatible interactions...
  36. pmc Tricking the guard: exploiting plant defense for disease susceptibility
    J Lorang
    Department of Botany and Plant Pathology and Center for Genome Research and Biocomputing, Oregon State University, Corvallis, OR 97331, USA
    Science 338:659-62. 2012
    ..presence, victorin binding to TRX-h5 activates LOV1 and elicits a resistance-like response that confers disease susceptibility. We propose that victorin is, or mimics, a conventional pathogen virulence effector that was defeated by ..
  37. ncbi Host resistance to malaria: using mouse models to explore the host response
    Rhea Longley
    Menzies Research Institute, University of Tasmania, 17 Liverpool Street, Hobart, TAS 7000, Australia
    Mamm Genome 22:32-42. 2011
    ..Perhaps the lessons learned from the natural variation in both the human populations and experimental mouse models of infection may pave the way for novel resistance-proof antimalarials...
  38. ncbi Impairment of host resistance to Listeria monocytogenes infection in liver of db/db and ob/ob mice
    Shin Ikejima
    Department of Bacteriology, Hirosaki University School of Medicine, Zaifu cho 5, Hirosaki, Aomori 036 8562, Japan
    Diabetes 54:182-9. 2005
    ..Moreover, defect of MCP-1 expression in the liver may be involved in the attenuated host resistance in these mutant mice...
  39. ncbi Genotypes of the mannan-binding lectin gene and susceptibility to visceral leishmaniasis and clinical complications
    Diego Peres Alonso
    Department of Parasitology, Institute for Biology and Biomedicine, Sao Paulo State University, Botucatu, Brazil
    J Infect Dis 195:1212-7. 2007
    ..This case-control study examines genotypes of MBL2 and levels of MBL in individuals presenting with different outcomes of infection with Leishmania chagasi...
  40. ncbi Early viral replication and induced or constitutive immunity in rainbow trout families with differential resistance to Infectious hematopoietic necrosis virus (IHNV)
    Maureen K Purcell
    U S Geological Survey, Western Fisheries Research Center, Seattle, WA 98115, USA
    Fish Shellfish Immunol 28:98-105. 2010
    ..In summary, disease outcome for each family was determined very early in the infection process and resistance was associated with lower early viral replication...
  41. pmc Generation of human vascular smooth muscle subtypes provides insight into embryological origin-dependent disease susceptibility
    Christine Cheung
    The Anne McLaren Laboratory for Regenerative Medicine, University of Cambridge, Cambridge, UK
    Nat Biotechnol 30:165-73. 2012
    ..This differentiation approach will have broad applications in modeling origin-dependent disease susceptibility and in developing bioengineered vascular grafts for regenerative medicine.
  42. pmc Non-redundant roles for LXRalpha and LXRbeta in atherosclerosis susceptibility in low density lipoprotein receptor knockout mice
    Eric D Bischoff
    Exelixis, Inc, San Diego, CA, USA
    J Lipid Res 51:900-6. 2010
    ..These studies indicate that LXRalpha plays a selective role in limiting atherosclerosis in response to hyperlipidemia...
  43. pmc Intradermal infections of mice by low numbers of african trypanosomes are controlled by innate resistance but enhance susceptibility to reinfection
    Guojian Wei
    Department of Veterinary Microbiology, University of Saskatchewan, Saskatoon, Canada
    J Infect Dis 203:418-29. 2011
    ..We suggest that intradermal infections with low numbers of trypanosomes or injections with trypanosomal lysates prime the adaptive immune system to suppress protective immunity to an intradermal challenge...
  44. pmc The entomological inoculation rate and Plasmodium falciparum infection in African children
    D L Smith
    Fogarty International Center, National Institutes of Health, Building 16, 16 Center Drive, Bethesda, Maryland 20892, USA
    Nature 438:492-5. 2005
    ..The results have important implications for public health interventions: the success of malaria control will depend heavily on whether efforts are targeted at those who are most at risk of infection...
  45. pmc Viral-like brain inflammation during development causes increased seizure susceptibility in adult rats
    M A Galic
    Epilepsy and Brain Circuits Program, Hotchkiss Brain Institute, Department of Neuroscience, University of Calgary, Calgary, Alberta, Canada
    Neurobiol Dis 36:343-51. 2009
    ..Thus, a novel model of viral CNS inflammation reveals pathophysiological relationships between brain cytokines, glutamate receptors, behaviour and seizures, which can be attenuated by anti-inflammatory agents like minocycline...
  46. ncbi Hyperacute ischemic stroke: middle cerebral artery susceptibility sign at echo-planar gradient-echo MR imaging
    Alex Rovira
    Department of Radiology, Magnetic Resonance Unit, Hospital Universitari Vall d Hebron, Passeig Vall d Hebron 119 129, 08035 Barcelona, Spain
    Radiology 232:466-73. 2004
    ..To evaluate the accuracy of echo-planar T2*-weighted magnetic resonance (MR) sequences in detection of acute middle cerebral artery (MCA) or internal carotid artery (ICA) thrombotic occlusion...
  47. ncbi Inflammation in the prediabetic state is related to increased insulin resistance rather than decreased insulin secretion
    Andreas Festa
    Department of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, Tex 78229 3900, USA
    Circulation 108:1822-30. 2003
    ..Previously, atherogenic changes in traditional CV risk factors in the prediabetic state were mainly seen in insulin-resistant subjects rather than in those with a predominant defect in insulin secretion...
  48. ncbi Long-term maternal high-fat feeding from weaning through pregnancy and lactation predisposes offspring to hypertension, raised plasma lipids and fatty liver in mice
    Maqsood M Elahi
    Institute of Developmental Sciences, Developmental Origins of Health and Disease Division, University of Southampton School of Medicine, Southampton General Hospital, Mailpoint 887, Southampton SO16 6YD, UK
    Br J Nutr 102:514-9. 2009
    ....
  49. pmc Either a Th17 or a Th1 effector response can drive autoimmunity: conditions of disease induction affect dominant effector category
    Dror Luger
    Laboratory of Immunology, National Eye Institute NEI, National Institutes of Health NIH, Bethesda, MD 20892, USA
    J Exp Med 205:799-810. 2008
    ..These data also raise the possibility that the nonredundant requirement for IL-23 in EAU may extend beyond its role in promoting the Th17 effector response and help provide a balance in the current Th1 versus Th17 paradigm...
  50. pmc Systemic lupus erythematosus-associated defects in the inhibitory receptor FcgammaRIIb reduce susceptibility to malaria
    Menna R Clatworthy
    Cambridge Institute for Medical Research and Department of Medicine, University of Cambridge, Cambridge, United Kingdom
    Proc Natl Acad Sci U S A 104:7169-74. 2007
    ....
  51. ncbi Human immunodeficiency virus-1 acquisition in genital mucosa: Langerhans cells as key-players
    M A W P de Jong
    Department of Molecular Cell Biology and Immunology, VU University Medical Center, Amsterdam, The Netherlands
    J Intern Med 265:18-28. 2009
    ..A better understanding of LCs function during homeostasis and inflammation is necessary for the development of new strategies to prevent HIV-1 infection...
  52. pmc Vaccinia virus E3 protein prevents the antiviral action of ISG15
    Susana Guerra
    Department of Molecular and Cellular Biology, Centro Nacional de Biotecnologia CSIC, Campus Universidad Autonoma, Madrid, Spain
    PLoS Pathog 4:e1000096. 2008
    ..These findings showed an anti-VACV function of ISG15, with the virus E3 protein suppressing the action of the ISG15 antiviral factor...
  53. pmc Type I interferon production enhances susceptibility to Listeria monocytogenes infection
    Ryan M O'Connell
    Department of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, 8 240 Factor Bldg, 10833 Le Conte Ave, 90095, USA
    J Exp Med 200:437-45. 2004
    ..Thus, our results highlight the disparate roles of type I IFNs during bacterial versus viral infections and stress the importance of proper IFN modulation in host defense...
  54. pmc Susceptibility to human immunodeficiency virus-1 infection of human foreskin and cervical tissue grown in explant culture
    Bruce K Patterson
    Department of Pediatrics, Division of Infectious Diseases, Children s Memorial Hospital, Chicago, Illinois 60614, USA
    Am J Pathol 161:867-73. 2002
    ..Adult foreskin mucosa had greater susceptibility to infection with HIV(bal) than cervical mucosa or the external surface of foreskin tissue. Circumcision likely reduces risk of HIV-1 acquisition in men by decreasing HIV-1 target cells...
  55. pmc Genetic mapping of quantitative trait loci affecting susceptibility to Marek's disease virus induced tumors in F2 intercross chickens
    R L Vallejo
    United States Department of Agriculture, Agricultural Research Service, Avian Disease and Oncology Laboratory, East Lansing, Michigan 48823, USA
    Genetics 148:349-60. 1998
    ..This study constitutes the first report in the domestic chicken on the mapping of non-major histocompatibility complex QTL affecting MD susceptibility...
  56. ncbi A 2-year prospective study in China provides epidemiological evidence for resistance in humans to re-infection with Schistosoma japonicum
    Y S Li
    Molecular Parasitology Unit, Australian Centre for International and Tropical Health and Nutrition, University of Queensland, Brisbane, Australia
    Ann Trop Med Parasitol 93:629-42. 1999
    ..Further investigation of these individuals should help to shed some light on the role of immunogenetic status in human immunity to Schistosoma japonicum...
  57. ncbi Gastrointestinal nematode expulsion in IL-4 knockout mice is IL-13 dependent
    A J Bancroft
    School of Biological Sciences, University of Manchester, GB
    Eur J Immunol 30:2083-91. 2000
    ..muris from the gut. Moreover, the present data highlight the functional importance of gender and background strain in interpretation of studies using gene-targeted animals...
  58. pmc Computational analysis of HIV-1 resistance based on gene expression profiles and the virus-host interaction network
    Tao Huang
    Key Laboratory of Systems Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, People s Republic of China
    PLoS ONE 6:e17291. 2011
    ..These proteins may be useful targets for AIDS prevention or therapy, as intervention in these pathways could disrupt communication with virus-targeted proteins and HIV-1 infection...
  59. ncbi Developmental plasticity and human health
    Patrick Bateson
    Sub Department of Animal Behaviour, University of Cambridge, High Street, Madingley, Cambridge CB3 8AA, UK
    Nature 430:419-21. 2004
    ..A fuller understanding of patterns of human plasticity in response to early nutrition and other environmental factors will have implications for the administration of public health...
  60. ncbi Norwalk virus infection and disease is associated with ABO histo-blood group type
    Anne M Hutson
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas 77030, USA
    J Infect Dis 185:1335-7. 2002
    ..096; 95% CI, 0.16-0.56) and symptomatic disease (OR, 0; 95% CI, 0-0.999). This is the first report demonstrating an association between a genetic factor and the risk of NV infection and symptomatic disease...
  61. pmc Diseases and causes of death in European bats: dynamics in disease susceptibility and infection rates
    Kristin Muhldorfer
    Leibniz Institute for Zoo and Wildlife Research, Berlin, Germany
    PLoS ONE 6:e29773. 2011
    ..But the impact of infectious agents on the individual host and their importance on bat mortality is largely unknown and has been neglected in most studies published to date...
  62. ncbi Measles outbreaks in a population with declining vaccine uptake
    V A A Jansen
    School of Biological Sciences, Royal Holloway University of London, Egham, Surrey TW20 0EX, UK
    Science 301:804. 2003
  63. pmc Susceptibility of human Th17 cells to human immunodeficiency virus and their perturbation during infection
    Aimee El Hed
    Departments of Microbiology, New York University School of Medicine, New York, NY 10016, USA
    J Infect Dis 201:843-54. 2010
    ..Identification of the Th17 T cell subset as important mediators of host defense and pathology prompted us to determine their susceptibility to human immunodeficiency virus (HIV) infection...
  64. ncbi Primary immunodeficiencies of protective immunity to primary infections
    Aziz Bousfiha
    Clinical Immunology Unit, Department of Pediatrics, CHU Ibn Rochd, Casablanca, Morocco
    Clin Immunol 135:204-9. 2010
    ..They provide proof-of-principle that infectious diseases of childhood striking only once may result from single-gene inborn errors of immunity...
  65. pmc Hypoxia-induced intrauterine growth restriction increases the susceptibility of rats to high-fat diet-induced metabolic syndrome
    Christian F Rueda-Clausen
    Department of Physiology, University of Alberta, Edmonton, Canada
    Diabetes 60:507-16. 2011
    ..Thus, we hypothesized that offspring born with IUGR exhibit permanent metabolic changes that make them more susceptible to HF diet-induced MetS...
  66. pmc Keratinization of the adult male foreskin and implications for male circumcision
    Minh H Dinh
    Division of Infectious Diseases, Department of Medicine, Chicago, Illinois 60611, USA
    AIDS 24:899-906. 2010
    ..We sought to quantify the keratin thicknesses of the inner and outer foreskin to determine the plausibility of this hypothesis...
  67. ncbi Peripheral blood CCR4+CCR6+ and CXCR3+CCR6+CD4+ T cells are highly permissive to HIV-1 infection
    Annie Gosselin
    Department of Microbiology and Immunology, Universite de Montreal, Montreal, Quebec, Canada
    J Immunol 184:1604-16. 2010
    ..It is necessary that new therapeutic strategies against HIV interfere with viral replication/persistence in discrete CCR6(+) T cell subsets...
  68. ncbi Predisposition to ascariasis: patterns, mechanisms and implications
    C V Holland
    Department of Zoology, School of Natural Sciences, Trinity College Dublin, Dublin 2, Ireland
    Parasitology 136:1537-47. 2009
    ..Furthermore, these patterns of Ascaris intensity and re-infection have broader implications with respect to helminth control and interactions with other important bystander infections...
  69. ncbi Susceptibility to mycobacterial infections in children with X-linked chronic granulomatous disease: a review of 17 patients living in a region endemic for tuberculosis
    Pamela P W Lee
    Department of Paediatrics and Adolescent Medicine, The University of Hong Kong, HKSAR, China
    Pediatr Infect Dis J 27:224-30. 2008
    ..Affected individuals are most prone to infections caused by staphylococci, Salmonella, Candida, and Aspergillus, but previously we observed a high incidence of Mycobacterium tuberculosis infection in Chinese children with CGD...
  70. ncbi Gram-positive bacteria enhance HIV-1 susceptibility in Langerhans cells, but not in dendritic cells, via Toll-like receptor activation
    Youichi Ogawa
    Department of Dermatology, University of Yamanashi, Japan
    Blood 113:5157-66. 2009
    ..Given these data, we hypothesize that ligation of TLR2 by Gram(+) bacterial products may underlie enhanced sexual transmission of HIV that occurs with concomitant bacterial sexually transmitted disease infections...
  71. pmc Viral replication and paracrine effects result in distinct, functional responses of dendritic cells following infection with dengue 2 virus
    Zachary D Nightingale
    University of Massachusetts Medical School, Worcester, MA 01655, USA
    J Leukoc Biol 84:1028-38. 2008
    ..These data demonstrate that functional maturation of DC in response to dengue infection is modified by the presence of virus through IFN-dependent and -independent mechanisms with consequences for the development of adaptive immunity...
  72. ncbi The insulin gene is transcribed in the human thymus and transcription levels correlated with allelic variation at the INS VNTR-IDDM2 susceptibility locus for type 1 diabetes
    A Pugliese
    Diabetes Research Institute, University of Miami School of Medicine, Florida, USA
    Nat Genet 15:293-7. 1997
    ..Higher levels of (pro)insulin in the thymus may promote negative selection (deletion) of insulin-specific T-lymphocytes which play a critical role in the pathogenesis of type-1 diabetes...
  73. ncbi Synergism of nutrition, infection, and immunity: an overview
    N S Scrimshaw
    Food and Nutrition Programme for Human and Social Development, United Nations University Program Office, Boston, MA 02114 0500, USA
    Am J Clin Nutr 66:464S-477S. 1997
    ..The effects observed with single or multiple nutrient deficiencies are due to some combination of these responses. In general, cell-mediated and nonspecific immunity are more sensitive than humoral immunity...
  74. ncbi Contribution of TNFSF15 gene variants to Crohn's disease susceptibility confirmed in UK population
    Mark Tremelling
    East Anglia IBD Research Group, Cambridge University Department of Medicine, Addenbrookes Hospital, Cambridge, UK
    Inflamm Bowel Dis 14:733-7. 2008
    ..of Crohn's disease (CD)-associated genetic variants is key to understanding pathogenic pathways underlying disease susceptibility. Recent reports of an association between TNFSF15 variants and CD have been modestly replicated in ..
  75. pmc Transmission barriers for bovine, ovine, and human prions in transgenic mice
    Michael R Scott
    Institute for Neurodegenerative Diseases, University of California, San Francisco, 94143 0518, USA
    J Virol 79:5259-71. 2005
    ..Single-amino-acid substitutions in chimeric PrP transgenes produced profound changes in incubation times that allowed us to distinguish prions causing BSE from those causing scrapie...
  76. ncbi Difference in susceptibility to malaria between two sympatric ethnic groups in Mali
    Amagana Dolo
    Malaria Research and Training Center, Département d épidémiologie des affections parasitaires, Faculte de Medecine, de Pharmacie et d Odonto Stomatologie, Bamako, Mali
    Am J Trop Med Hyg 72:243-8. 2005
    ..The Fulani group had significantly higher levels of IgG and IgE against crude malaria antigen than the Dogon group, suggesting a role of anti-malaria antibodies in the immune protection seen in this group...
  77. ncbi The role of sexually transmitted diseases in HIV transmission
    Shannon R Galvin
    Division of Infectious Diseases, University of North Carolina, Chapel Hill, North Carolina 27599 7030, USA
    Nat Rev Microbiol 2:33-42. 2004
    ..Targeted STD detection and treatment should have a central role in HIV prevention in these emerging epidemics...
  78. pmc Prion protein (PrP) with amino-proximal deletions restoring susceptibility of PrP knockout mice to scrapie
    M Fischer
    Institut für Molekularbiologie der Universität Zürich, Switzerland
    EMBO J 15:1255-64. 1996
    ....
  79. pmc Networks and epidemic models
    Matt J Keeling
    Department of Biological Sciences and Mathematics, University of Warwick, Institute Gibbet Hill Road, Coventry CV4 7AL, UK
    J R Soc Interface 2:295-307. 2005
    ..Finally, we look to the future to suggest how the two fields of network theory and epidemiological modelling can deliver an improved understanding of disease dynamics and better public health through effective disease control...
  80. ncbi Differential macrophage polarization in male and female BALB/c mice infected with coxsackievirus B3 defines susceptibility to viral myocarditis
    Kang Li
    Institute for Immunobiology, Department of Immunology, Shanghai Medical College of Fudan University, Shanghai, People s Republic of China
    Circ Res 105:353-64. 2009
    ..Interestingly, comparable macrophage numbers were observed in the myocardium of female mice during acute myocarditis...
  81. ncbi Clinical Implication of the C Allele of the ITPKC Gene SNP rs28493229 in Kawasaki Disease: Association With Disease Susceptibility and BCG Scar Reactivation
    Ming Tai Lin
    Department of Pediatrics, National Taiwan University Hospital and College of Medicine, National Taiwan University, Taipei, Taiwan
    Pediatr Infect Dis J 30:148-52. 2011
    ..a functional single nucleotide polymorphism (SNP) (rs28493229) in the inositol 1,4,5-trisphosphate 3-kinase C (ITPKC) gene has been linked to the susceptibility to Kawasaki disease (KD). The implication remains unclear...
  82. ncbi Environmental factors and their timing in adult-onset multiple sclerosis
    Adam E Handel
    University Department of Clinical Neurology, Level 3, West Wing, John Radcliffe Hospital, Oxford OX3 9DU, UK
    Nat Rev Neurol 6:156-66. 2010
    ..Understanding the nature of environmental influences in MS is highly relevant to the development of public health measures that are aimed at preventing this debilitating disease...
  83. pmc Susceptibilities of nonhuman primates to chronic wasting disease
    Brent Race
    Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, Hamilton, Montana 59840, USA
    Emerg Infect Dis 15:1366-76. 2009
    ..Thus, these 2 species differed in susceptibility to CWD. Because humans are evolutionarily closer to macaques than to squirrel monkeys, they may also be resistant to CWD...
  84. ncbi The neurobiology of multiple sclerosis: genes, inflammation, and neurodegeneration
    Stephen L Hauser
    Department of Neurology, School of Medicine, University of California at San Francisco, San Francisco, California 94143, USA
    Neuron 52:61-76. 2006
    ..Together, these advances have set the stage for the development of therapeutic approaches designed to target the demyelinating and neurodegenerative components of the disease and promote repair...
  85. pmc Both influenza-induced neutrophil dysfunction and neutrophil-independent mechanisms contribute to increased susceptibility to a secondary Streptococcus pneumoniae infection
    Lynnelle A McNamee
    Veterinary Molecular Biology Department, Montana State University, 960 Technology Blvd, Bozeman, MT 59718, USA
    Infect Immun 74:6707-21. 2006
    ..Thus, an influenza infection of 6 days increases susceptibility to S. pneumoniae by both suppression of neutrophil function and by neutrophil-independent mechanisms such as enhanced cytokine production...
  86. pmc Blood group, immunity, and risk of infection with Vibrio cholerae in an area of endemicity
    Jason B Harris
    Division of Infectious Diseases, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA
    Infect Immun 73:7422-7. 2005
    ..Based on this epidemiologic evidence, we propose a hypothesis for understanding the association between blood group O and the risk of infection with V. cholerae O1 and O139 as well as the risk of developing severe symptoms once infected...
  87. ncbi Lack of association between macrophage migration inhibitory factor-173 gene polymorphism with disease susceptibility and cardiovascular risk in rheumatoid arthritis patients from northwestern Spain
    R Palomino-Morales
    Instituto de Parasitologia y Biomedicina, Lopez Neyra, Consejo Superior de Investigaciones Cientificas CSIC, Granada, Spain
    Clin Exp Rheumatol 28:68-72. 2010
    ..of the macrophage migration inhibitory factor (MIF) gene at the position -173 is implicated in the disease susceptibility, risk of cardiovascular (CV) events and presence of subclinical atherosclerosis in patients with ..
  88. ncbi Placental insufficiency leads to development of hypertension in growth-restricted offspring
    Barbara T Alexander
    Department of Physiology and Biophysics, University of Mississippi Medical Center, 2500 N State St, Jackson, MS 39216 4505, USA
    Hypertension 41:457-62. 2003
    ..05). These data suggest that placental insufficiency induced by reduced uterine perfusion in the pregnant rat results in low-birth-weight offspring predisposed to development of hypertension...
  89. ncbi Role of atypical bacterial infection of the lung in predisposition/protection of asthma
    Philip M Hansbro
    Discipline of Immunology and Microbiology, School of Biomedical Sciences, University of Newcastle, Callaghan, New South Wales, Australia
    Pharmacol Ther 101:193-210. 2004
    ....
  90. ncbi Frequency, severity, and duration of rhinovirus infections in asthmatic and non-asthmatic individuals: a longitudinal cohort study
    Jonathan M Corne
    University Medicine, Southampton General Hospital, Southampton, UK
    Lancet 359:831-4. 2002
    ..Rhinovirus infections cause exacerbations of asthma. We postulated that people with asthma are more susceptible to rhinovirus infection than people without the disease and compared the susceptibility of these groups...
  91. pmc Common and rare variants in multifactorial susceptibility to common diseases
    Walter Bodmer
    Cancer and Immunogenetics Laboratory, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DS, UK
    Nat Genet 40:695-701. 2008
    ....
  92. ncbi Race-specific differences in endothelial function: predisposition of African Americans to vascular diseases
    Leszek Kalinowski
    Department of Biochemistry, Ohio University, Athens, OH 45701, USA
    Circulation 109:2511-7. 2004
    ..We hypothesized that the differences in endothelial NO/O2-/ONOO- metabolism may highlight the potential predisposition to endothelial dysfunction and cardiovascular complications prevalent in blacks...
  93. ncbi Pathogen dose infectivity curves as a method to analyze the distribution of host susceptibility: a quantitative assessment of maternal effects after food stress and pathogen exposure
    Frida Ben-Ami
    Zoologisches Institut, Evolutionsbiologie, Universitat Basel, Vesalgasse 1, CH 4051 Basel, Switzerland
    Am Nat 175:106-15. 2010
    ..The finding of an alteration in the variance of susceptibility to infection has implications for host and parasite dynamics and can contribute to our understanding of the stability of host-parasite interactions...
  94. ncbi Parvovirus infections in wild carnivores
    A Steinel
    Institute for Medical Microbiology, Infectious and Epidemic Diseases, University of Munich, Germany
    J Wildl Dis 37:594-607. 2001
    ..Particular emphasis is placed on description of the evolution of canine parvovirus which apparently involved wild carnivore hosts...
  95. ncbi Seizure susceptibility and the brain regional sensitivity to oxidative stress in male and female rats in the lithium-pilocarpine model of temporal lobe epilepsy
    Sandra Peternel
    Department of Pharmacology, Faculty of Medicine, University of Rijeka, Rijeka, Croatia
    Prog Neuropsychopharmacol Biol Psychiatry 33:456-62. 2009
    ....
  96. pmc Tissue tropism and neuroinvasion of West Nile virus do not differ for two mouse strains with different survival rates
    Ashley N Brown
    Wadsworth Center, New York State Department of Health, P O Box 509, Albany, NY 12201 0509, USA
    Virology 368:422-30. 2007
    ..Our data suggest that the disparities in morbidity and mortality between C3H and B6 mice are not due to differences in tropism, viral load or kinetics during acute WNV infection...
  97. pmc Integrating susceptibility into environmental policy: an analysis of the national ambient air quality standard for lead
    Ramya Chari
    RAND Corporation, 1200 South Hayes Street, Arlington, VA 22202, USA
    Int J Environ Res Public Health 9:1077-96. 2012
    ..Results are used to frame discussion regarding why cumulative risk assessment methodologies are needed to help inform policy development...
  98. ncbi Hematopoietic stem cell-engrafted NOD/SCID/IL2Rgamma null mice develop human lymphoid systems and induce long-lasting HIV-1 infection with specific humoral immune responses
    Satoru Watanabe
    Department of Virology, Division of Medical Science, Medical Research Institute, Tokyo Medical and Dental University, Japan
    Blood 109:212-8. 2007
    ..Thus, the hNOG mice mirror human systemic HIV infection by developing specific antibodies, suggesting that they may have potential as an HIV/AIDS animal model for the study of HIV pathogenesis and immune responses...
  99. ncbi The relative importance of CD4+ and CD8+T cells in immunity to pulmonary paracoccidioidomycosis
    Andressa P Chiarella
    Departamento de Imunologia do Instituto de Ciências Biomédicas da Universidade de São Paulo, Av Prof Lineu Prestes 1730, CEP 05508 900, Sao Paulo, Brazil
    Microbes Infect 9:1078-88. 2007
    ....
  100. pmc Expanding the scope of risk assessment: methods of studying differential vulnerability and susceptibility
    Joel Schwartz
    School of Public Health, Harvard University, Boston, MA, USA
    Am J Public Health 101:S102-9. 2011
    ..The Environmental Protection Agency should make this a standard part of their risk assessments whenever the necessary information is available...
  101. pmc α1-Acid glycoprotein decreases neutrophil migration and increases susceptibility to sepsis in diabetic mice
    Fernando Spiller
    Department of Pharmacology, Biological Sciences Center, Federal University of Santa Catarina, Florianopolis, Santa Catarina, Brazil
    Diabetes 61:1584-91. 2012
    ..Together, these data suggest that AGP may be involved in reduction of neutrophil migration and increased susceptibility to sepsis in diabetic mice...

Research Grants69

  1. BIOCHEMISTRY OF PRE-MRNA SPLICING
    Adrian R Krainer; Fiscal Year: 2010
    ..The proposed studies are aimed at understanding basic cellular mechanisms of gene expression, and may provide the basis for developing or improving diagnostic tools and therapeutic agents for these diseases. ..
  2. MAPPING OF ARTHRITIS SUSCEPTIBILITY GENES
    Tibor T Glant; Fiscal Year: 2013
    ..Association of age and gender with disease development and severity, and recessive inheritance of disease susceptibility, dictated by both the major histocompatibility complex (MHC)- and non-MHC-associated genes are additional ..
  3. Mechanisms Regulating Reduced c-Kit-Dependent EAE Susceptibility in Male SJL Mice
    MELISSA ANN BROWN; Fiscal Year: 2013
    ..their protective influence 2) Identify whether and how mast cells or other c-kit related factors alter disease susceptibility in males...
  4. Genetic Epidemiology of Life-Threatening Influenza Infection in Children
    Adrienne Randolph; Fiscal Year: 2009
    ..trial investigators, was developed to evaluate how the host innate immune response is associated with disease susceptibility and clinical outcome...
  5. Genome-wide DNA Methylation Profiles Associated with Abnormal Intrauterine Growth
    Cristina Montagna; Fiscal Year: 2013
    ..restriction (IUGR) and large for gestational age (LGA)), can have major effects in determining long-term disease susceptibility, particularly in regards to T2DM and cardiovascular disease(2)...
  6. The Role of Carboxypeptidase B and its Substrates in Rheumatoid Arthritis
    William H Robinson; Fiscal Year: 2013
    ..representing the CPB2 gene showed that the minor allele SNP rs1409433 was associated with a reduced RA disease susceptibility. The non- synonymous C1064T CPB SNP is in strong linkage disequilibrium with rs1409433, and the C1064T ..
  7. Contribution of Gstm1 to the severity of hypertension and chronic kidney disease
    Thu H Le; Fiscal Year: 2013
    ..direct proof of causality and the exact molecular mechanism by which loss of the gene product causes disease susceptibility have not been established...
  8. Endothelial Progenitor Cells in Brain Arteriovenous Malformations
    Yongmei Chen; Fiscal Year: 2010
    ..The etiology and pathogenesis are unknown and better understanding of the molecular events influencing disease susceptibility and clinical progression is needed to optimize patient care...
  9. Lung Toxicity of Carbon Nanotubes in Models of Pre-Existing Respiratory Disease
    JAMES CHRISTOPHER BONNER; Fiscal Year: 2010
    ..we will specifically modify the surface chemistry of carbon nanotubes to determine whether toxicity and disease susceptibility is increased or decreased...
  10. HLA-D Region in Systemic Lupus Erythematosus Pathogenesis
    Shu Man Fu; Fiscal Year: 2013
    ..into consideration the three main features of SLE: 1) the HLA-D complex is a dominant genetic loci for disease susceptibility;2) there is a considerable latent period between the detection of the first autoantibody (auto-Ab) and ..
  11. Mitochondrial Biomarkers of Cardiomyopathy and Cure in Chagas Disease
    Nisha Jain Garg; Fiscal Year: 2013
    ..this proposal, we will develop tools to capture the mitochondrial alterations as an indicator of cardiac disease susceptibility and efficacy (or toxicity) of a particular treatment in chagasic patients...
  12. Nrf2 as a Master Regulator in Liver Disease Prevention and Therapy
    Curtis D Klaassen; Fiscal Year: 2012
    ..mice with differential Nrf2 activity, namely Nrf2-null, wild-type, and Nrf2-enhanced mice, to test liver disease susceptibility in 13 different models...
  13. Glucocerebrosidase mutations in a mouse synucleinopathy model
    Robert L Nussbaum; Fiscal Year: 2011
    ..disease in humans along with changes in the expression of the enzyme glucocerebrosidase, a Parkinson disease susceptibility risk factor...
  14. Genetic Epidemiology of Life-Threatening Influenza in Children
    Adrienne G Randolph; Fiscal Year: 2013
    ..conducted during an influenza pandemic, evaluates how the host innate immune response is associated with disease susceptibility, severity and outcome...
  15. The Vaginal Microbiome: Disease, Genetics and the Environment
    GREGORY ALLEN BUCK; Fiscal Year: 2012
    ..to be investigated as potential selective conditions for change in the "normal" flora, and their impact on disease susceptibility and transmission remains to be more definitively elucidated...
  16. Polymorphism and mutation spectrum in minorities with non-small cell lung cancer
    David P Carbone; Fiscal Year: 2010
    ..Thus efforts to better understand the molecular basis for disease susceptibility, incidence, progression, prognosis, and response to biologic agents among the common U.S...
  17. Genome Sequencer FLX Instrument
    ANNE VIRGINIA KANE; Fiscal Year: 2010
    ..Research on genetic markers of cardiac disease susceptibility, the association of G protein-coupled receptor variants with obesity, genetic risk factors for pulmonary ..
  18. Genetics of risk of chemotherapy-induced cardiotoxicity in cancer survivors
    Peter Demant; Fiscal Year: 2013
    ..mouse recombinant congenic (RC) strains - a powerful mapping tool that allowed us to detect >130 novel disease susceptibility genes and to show that their homologues can affect human disease...
  19. GLYCOSYLTRANSFERASE FUNCTION IN DEVELOPMENT AND DISEASE
    JAMEY MARTH; Fiscal Year: 2013
    ..dietary responses leading to insufficient GnT-4a and glucose transport are responsible for strain-specific disease susceptibility. The unexpected conservation of this diabetogenic pathway in mammals suggests the possibility that ..
  20. Immune function and the progression to type 1 diabetes
    Mark A Atkinson; Fiscal Year: 2013
    ..therapeutic capable of preventing and/or reversing T1D, as well as to provide novel biomarkers for disease susceptibility and autoimmune activity associated with the disease...
  21. Epigenetic Biomarkers of Common Chronic Diseases
    Sharon L Kardia; Fiscal Year: 2010
    ..and have been hypothesized as a link between environmental factors, lifestyle, and alterations in chronic disease susceptibility(5, 6)...
  22. Preclinical Alzheimers Disease Drug Development of Novel MAPK Inhibitors
    DANIEL MARTIN WATTERSON; Fiscal Year: 2013
    ..Regardless of whether the mechanism is a direct causative one or a contributor to disease susceptibility and onset, small molecule modulators of the process would be a major step in development of therapeutic ..
  23. Genetic Variations and Development of Vesicoureteral Reflux and Sequelae
    DAVID SULLIVAN HAINS; Fiscal Year: 2010
    ..number can have profound effects on gene dosage, and alterations in DNA copy number play a key role in disease susceptibility or resistance...
  24. NEXT GENERATION SEQUENCING ADD-ON-PHARMACOGENOMICS RESEARCH NETWROK (PGRN)
    Elaine R Mardis; Fiscal Year: 2013
    ..Downstream functional studies may further enhance our understanding of how these variants play a role in disease susceptibility, onset or severity...
  25. Genome-wide association to Staphylococcus carriage
    Craig L Hanis; Fiscal Year: 2013
    ..It will also allow determining the role/interaction of Type-2 diabetes and S. aureus carriage/disease susceptibility. Success of genome-wide association studies depends on innovative and rigorous data analysis and ..
  26. Integrating cell sorting and tissue shaping mechanisms during cornea maturation
    Philip M Iannaccone; Fiscal Year: 2010
    ..Diverse paradigms are being developed in which investigators are focusing on characterizing disease susceptibility, quantifying measures for diagnoses, characterizing wound-healing/fibrotic behaviors, designing artificial ..
  27. Exosome-induced innate and antigen-specific immune responses in Type 1 Diabetes
    Yang D Dai; Fiscal Year: 2013
    ..tissue-specific autoimmune disease, in which the class II MHC genes play a major role controlling the disease susceptibility. This suggests that islet autoantigens and their short peptides presented on the MHC molecules are the key ..
  28. Gene Expression Effect of Antioxidant Supplementation on Epithelium of Lung:ExSEL
    Patricia A Cassano; Fiscal Year: 2010
    ..The current understanding of COPD pathogenesis implicates an oxidant/antioxidant imbalance in disease susceptibility. Although 80-90% of COPD patients are current or former smokers, only 15% of the variation in lung ..
  29. In Utero Exposure to Bisphenol A: Effects on the Fetal Epigenome
    DANA DOLINOY; Fiscal Year: 2013
    ..firmly established that environmental exposures during early embryonic development play a critical role in disease susceptibility in later life...
  30. Stress, Cellular Aging and Susceptibility to Infectious Disease
    Sheldon A Cohen; Fiscal Year: 2010
    ..This evidence suggests that stress may influence disease susceptibility via its effects on lymphocyte cell senescence...
  31. Molecular Genetics of Pathogen Recognition Receptors in COPD
    Tricia D LeVan; Fiscal Year: 2013
    ..is that with different environmental exposures, different genes may be activated and contribute to disease susceptibility. Single nucleotide polymorphisms in these receptors and their accessory molecules have been identified;..
  32. MicroRNA-mediated regulation of ATG16L1 expression and autophagy
    John Kwon; Fiscal Year: 2012
    ..by applicant) ATG16L1 was recently identified in genome-wide association studies as a Crohn's disease susceptibility gene, thereby implicating autophagy in the pathogenesis of Crohn's disease...
  33. TOX, a Novel Regulator of Thymocyte Selection
    JONATHAN G KAYE; Fiscal Year: 2013
    ..to reconstitute the immune system where necessary due to disease, and also may have future impact in treatment for breast cancer, since a gene encoding one member of this protein family has been mapped as a disease susceptibility locus.
  34. African Diversity and the Genetics of Human Health
    Joseph P Jarvis; Fiscal Year: 2011
    ..to physical environmental factors including growth rate and body composition, and to infectious disease susceptibility including modified immune system function...
  35. Genetic Discovery and Application in a Clinical Setting Continuing a Partnership
    Eric B Larson; Fiscal Year: 2013
    ..Target phenotypes are infectious disease susceptibility, specifically to Clostridium difficile diarrhea, shingles from varicella zoster virus, and fungal nail ..
  36. Genetic Susceptibility to Nanoparticle-Induced Respiratory Disease
    JAMES CHRISTOPHER BONNER; Fiscal Year: 2013
    ..to specifically modify the surface chemistry of carbon nanotubes to determine whether toxicity and disease susceptibility are increased or decreased...
  37. p38 MAPK as a female-specific druggable target in CNS autoimmune disease
    Cory Teuscher; Fiscal Year: 2012
    ..important, since many autoimmune diseases, including MS, exhibit a female-specific sexual dimorphism in disease susceptibility. The finding that SB203580 is fully capable of selectively inhibiting disease in females provides for the ..
  38. TIM recognition of phosphatidylserine regulates innate and adaptive immunity
    Dale T Umetsu; Fiscal Year: 2013
    ..RELEVANCE (See instructions): The 7//W genes have been shown to be important disease susceptibility genes (asthma, allergy, atopic dermatitis, food allergy and rheumatoid arthritis) and to potently regulate ..
  39. T Cell Homeostasis and Function in Immune Senescence
    Janko Nikolich-Zugich; Fiscal Year: 2012
    ..We will define, using a reductionist approach, the features of T-cell aging and infectious disease susceptibility that are driven by loss of T-cell diversity and aberrant memory maintenance associated with latent viral ..
  40. Interactions and mechanisms of function of the TAP Complex
    Malini Raghavan; Fiscal Year: 2013
    ..of how trafficking differences between HLA-B allotypes impact their antigen presenting ability will be important for better elucidating the effects of different HLA antigens on disease susceptibility, resolution, and progression.
  41. Large-Scale Discovery of Functional Genetic Variation in Rhesus Macaques
    JEFFREY A ROGERS; Fiscal Year: 2011
    ..We will facilitate research on the genetic basis of disease susceptibility and response to treatment by identifying large numbers of new DNA sequence variants in functional genes ..
  42. Genetics of susceptibility to candidiasis
    Scott Filler; Fiscal Year: 2009
    ..QTLs)--that may contain genes whose variations are responsible for these strain-to-strain differences in disease susceptibility. The results of this analysis identified 78 and 176 genes in which polymorphisms may be associated with ..
  43. Impact of genetic variation TLR/CD14 pathways and smoking in RA
    TED RICHARD MIKULS; Fiscal Year: 2011
    ..However, there is increasing data showing that cigarette smoking, associated with disease susceptibility, is also associated with RA outcomes and its effect is likely modified by HLA-DRB1 alleles encoding the ..
  44. Genetic Susceptibility to Non-Hodgkins Lymphoma
    Christine F Skibola; Fiscal Year: 2012
    ..for family genetics has been established in causing lymphoma and common genetic variants may influence disease susceptibility. These studies will use genetics to increase our understanding of how lymphoma develops in the body and ..
  45. Interferon Alpha as a Tool for Gene Discovery in Human Lupus
    Timothy B Niewold; Fiscal Year: 2013
    ..in SLE have identified numerous novel susceptibility loci, most of which have a modest overall effect on disease susceptibility (odds ratios 1.2-1.3)...
  46. Large-Scale Discovery of Functional Genetic Variation in Rhesus Macaques
    JEFFREY A ROGERS; Fiscal Year: 2013
    ..We will facilitate research on the genetic basis of disease susceptibility and response to treatment by identifying large numbers of new DNA sequence variants in functional genes ..
  47. Polysaccharide Antibody Repertoires
    Alexander H Lucas; Fiscal Year: 2010
    ..They will identify genetic determinants of Ab efficacy and disease susceptibility, elucidate the cells and processes involved in the immune response to pediatric vaccines, and delineate ..
  48. Study of FcR Genes: Macrophages and Lymphocytes
    JEFFREY VICTOR RAVETCH; Fiscal Year: 2013
    ..been accumulated in human populations that inappropriate regulation of FcgRIIB is a likely contributor to disease susceptibility and progression, direct experimental evidence has been lacking...
  49. Genetics of Hypertension Risk Factors and Sequela in African Americans
    Yan Sun; Fiscal Year: 2010
    ..Aim 2: To identify genome-wide regions containing evidence of disease susceptibility loci for hypertension, obesity, left ventricular hypertrophy, and kidney function, we will perform ..
  50. Unbiased Forward Genetic Analysis of Virus/Host Interactions
    Richard L Thompson; Fiscal Year: 2010
    ..expected to yield insights into potential new preventative and treatment options, biomarkers predictive of disease susceptibility and severity, and importantly, personalized medical risk assessment and treatment strategies...
  51. Genetic & Epigenetic Modifiers of Maternal-Fetal Transfer of Toxicants & Outcomes
    Adrienne S Ettinger; Fiscal Year: 2011
    ..research areas pertinent to the NIEHS areas of special interest: "Single Nucleotide Polymorphisms and Disease Susceptibility" and "Epigenetics: Role in Environmentally Induced Diseases/Dysfunction...
  52. SUSCEPTIBILILTY GENE-VIRUS INTERACTIONS IN INFLAMMATORY BOWEL DISEASE
    Herbert W Virgin; Fiscal Year: 2013
    ..with dsRNA triggers Crohn's disease-like phenotypes in mice carrying a mutation in the Crohn's disease susceptibility-linked autophagy gene Atg16L1...
  53. Gene-environments and Admixture in Latino Asthmatics (GALA 2)
    Esteban Gonzalez Burchard; Fiscal Year: 2012
    ..studies of complex traits and may be useful in untangling complex gene-environment (G x E) interactions in disease susceptibility. We hypothesize that ancestry will modify the association between environmental risk factors and asthma ..
  54. The MHC of wild chimpanzees: genetic variation, disease and reproductive success
    EMILY ELIZABETH WROBLEWSKI; Fiscal Year: 2012
    ..Tanzania;2) Examine the correlation between MHC genotype and health measures, including parasite load and disease susceptibility;3) Investigate the relationship between MHC genotype and reproductive success...
  55. Immuno-pathophysiology of Lymphocytic Foci in Sjogren?s Syndrome
    Cuong Q Nguyen; Fiscal Year: 2013
    ..in SjS with women affected 10- to 20-times more frequently than men, suggesting a role for sex hormones in disease susceptibility or progression...
  56. Mouse Model of Age-Associated Monoclonal Gammopathy
    Peter Leif Bergsagel; Fiscal Year: 2013
    ..This project will use genetically engineered mice to dissect the mechanisms of disease susceptibility, biology and progression, performing studies that cannot be done in man, but with direct relevance to the ..
  57. Profiling the circadian transcriptome of Drosophila nervous system using RNA sequ
    MICHAEL EVAN HUGHES; Fiscal Year: 2012
    ..tissues, with the ultimate goal of deepening our understanding of how circadian rhythms contribute to disease susceptibility. To this end, transgenic technologies will be employed to label and purify distinct subpopulations of ..
  58. Transgenerational Effects of Nicotine
    Andrew R Tapper; Fiscal Year: 2013
    ..and drug exposure on offspring metabolism and behavior will be required for a detailed understanding of disease susceptibility. In other words, many diseases with complex genetic bases may also be subject to confounding epigenetic ..
  59. Nuclear Receptor DNA Binding in Human Physiology and Disease
    Frances M Sladek; Fiscal Year: 2013
    ..targets of many successful drugs, we still do not have a complete understanding of their role in disease susceptibility nor in individual responses to drug treatments...
  60. The Role of Jam-A in Regulating Intestinal Antigen Presenting Cell Function and I
    Charles A Parkos; Fiscal Year: 2010
    ..Alterations in the integrity of the intestinal epithelial barrier can have a profound impact on intestinal disease susceptibility. While there are associations between increased intestinal epithelial permeability predating the onset of ..
  61. A novel atherosclerosis locus on mouse chromosome 4
    CARRIE LYNN WELCH; Fiscal Year: 2013
    ..association studies have met with recent success in identifying candidate regions of the genome harboring disease susceptibility genes, determining genotype-phenotype relations in humans is difficult due to genetic complexity...
  62. Early Life DNA Methylation and Childhood Allergic Disease
    Augusto A Litonjua; Fiscal Year: 2013
    ..materials (such as DNA from cord blood) is important due to the potential utility as biomarkers of disease susceptibility. The overall hypothesis of this application is that DNA methylation changes that occur in early life will ..
  63. The Vaginal Microbiome: Disease, Genetics and the Environment
    Gregory Buck; Fiscal Year: 2009
    ..to be investigated as potential selective conditions for change in the "normal" flora, and their impact on disease susceptibility and transmission remains to be more definitively elucidated...
  64. EFFECT OF APOLIPOPROTEIN STRUCTURAL ADAPTABILITY
    ROBERT O apos MARA RYAN; Fiscal Year: 2010
    ..how molecular interactions between lipoproteins and cell surface receptors affect lipid metabolism and disease susceptibility. Knowledge of the metabolic roles of apolipoprotein (apo) E and low-density lipoprotein receptor (LDLR) ..
  65. GENETIC CONTROL OF NEUROMUSCULAR DEGENERATION IN MICE
    Gregory Cox; Fiscal Year: 2002
    ..mouse mutants affecting motor neuron survival provides a powerful alternative means to understanding disease susceptibility and progression...
  66. GENETICS OF ANTIBODIES TO PERIODONTAL PATHOGENS
    JEROME HABER; Fiscal Year: 1990
    ..An attractive explanation for differences in disease susceptibility is genetically controlled variations in the antibody response to adherence associated structures on ..
  67. Development Modulation of Mouse Uterine Tumorigenesis
    Shuk Mei Ho; Fiscal Year: 2006
    ..to long-term imprinting effects of estrogenic chemicals that are known to have profound effects on adult disease susceptibility. Genistein, a naturally occurring isoflavone found in soy, is recognized as a dietary estrogen as it ..
  68. LMP POLYMORPHISMS IN B27-ASSOCIATED JUVENILE ARTHRITIS
    Robert Colbert; Fiscal Year: 2001
    ..allelic variants may influence the production of peptide epitopes presented by HLA-B27, thus influencing disease susceptibility in these individuals...
  69. MURINE CRD: A MODEL OF CHRONIC PULMONARY IMFLAMMATION
    Gail Cassell; Fiscal Year: 1991
    ..pathogens, and a highly reproducible model has been established using differences in LEW and F344 rats in disease susceptibility. The recognized morphologic similarities and similar natural histories of chronic respiratory diseases of ..