critical illness

Summary

Summary: A disease or state in which death is possible or imminent.

Top Publications

  1. pmc Acute renal failure - definition, outcome measures, animal models, fluid therapy and information technology needs: the Second International Consensus Conference of the Acute Dialysis Quality Initiative (ADQI) Group
    Rinaldo Bellomo
    Department of Intensive Care and Medicine, Austin Health, Melbourne, Australia
    Crit Care 8:R204-12. 2004
  2. doi Mortality after fluid bolus in African children with severe infection
    Kathryn Maitland
    Kilifi Clinical Trials Facility, Kenya Medical Research Institute KEMRI Wellcome Trust Research Programme, Kilifi, Kenya
    N Engl J Med 364:2483-95. 2011
  3. ncbi A comparison of albumin and saline for fluid resuscitation in the intensive care unit
    Simon Finfer
    ANZICS CTG, Level 3, 10 Ievers St, Carlton, VIC 3053, Australia
    N Engl J Med 350:2247-56. 2004
  4. ncbi Incidence and prognosis of intraabdominal hypertension in a mixed population of critically ill patients: a multiple-center epidemiological study
    Manu L N G Malbrain
    Intensive Care Unit Director, Medical Intensive Care Unit, Ziekenhuis Netwerk Antwerpen, Campus Stuivenberg, Lange Beeldekensstraat 267, B 2060 Antwerpen 6, Belgium
    Crit Care Med 33:315-22. 2005
  5. pmc Intensity of renal support in critically ill patients with acute kidney injury
    Paul M Palevsky
    N Engl J Med 359:7-20. 2008
  6. pmc A genomic storm in critically injured humans
    Wenzhong Xiao
    Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    J Exp Med 208:2581-90. 2011
  7. doi Dexmedetomidine vs midazolam for sedation of critically ill patients: a randomized trial
    Richard R Riker
    University of Vermont College of Medicine, USA
    JAMA 301:489-99. 2009
  8. doi Serum lactate is associated with mortality in severe sepsis independent of organ failure and shock
    Mark E Mikkelsen
    Pulmonary, Allergy, and Critical Care Division, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Crit Care Med 37:1670-7. 2009
  9. ncbi Accuracy of procalcitonin for sepsis diagnosis in critically ill patients: systematic review and meta-analysis
    Benjamin M P Tang
    Department of Intensive Care Medicine, Nepean Hospital, Penrith, New South Wales, Australia
    Lancet Infect Dis 7:210-7. 2007
  10. doi Early versus late parenteral nutrition in critically ill adults
    Michael P Casaer
    Department of Intensive Care Medicine, University Hospitals of the Catholic University of Leuven, Leuven, Belgium
    N Engl J Med 365:506-17. 2011

Detail Information

Publications434 found, 100 shown here

  1. pmc Acute renal failure - definition, outcome measures, animal models, fluid therapy and information technology needs: the Second International Consensus Conference of the Acute Dialysis Quality Initiative (ADQI) Group
    Rinaldo Bellomo
    Department of Intensive Care and Medicine, Austin Health, Melbourne, Australia
    Crit Care 8:R204-12. 2004
    ..Accordingly, we sought to review the available evidence, make recommendations and delineate key questions for future studies...
  2. doi Mortality after fluid bolus in African children with severe infection
    Kathryn Maitland
    Kilifi Clinical Trials Facility, Kenya Medical Research Institute KEMRI Wellcome Trust Research Programme, Kilifi, Kenya
    N Engl J Med 364:2483-95. 2011
    ..The role of fluid resuscitation in the treatment of children with shock and life-threatening infections who live in resource-limited settings is not established...
  3. ncbi A comparison of albumin and saline for fluid resuscitation in the intensive care unit
    Simon Finfer
    ANZICS CTG, Level 3, 10 Ievers St, Carlton, VIC 3053, Australia
    N Engl J Med 350:2247-56. 2004
    ..We conducted a multicenter, randomized, double-blind trial to compare the effect of fluid resuscitation with albumin or saline on mortality in a heterogeneous population of patients in the ICU...
  4. ncbi Incidence and prognosis of intraabdominal hypertension in a mixed population of critically ill patients: a multiple-center epidemiological study
    Manu L N G Malbrain
    Intensive Care Unit Director, Medical Intensive Care Unit, Ziekenhuis Netwerk Antwerpen, Campus Stuivenberg, Lange Beeldekensstraat 267, B 2060 Antwerpen 6, Belgium
    Crit Care Med 33:315-22. 2005
    ....
  5. pmc Intensity of renal support in critically ill patients with acute kidney injury
    Paul M Palevsky
    N Engl J Med 359:7-20. 2008
    ..The optimal intensity of renal-replacement therapy in critically ill patients with acute kidney injury is controversial...
  6. pmc A genomic storm in critically injured humans
    Wenzhong Xiao
    Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    J Exp Med 208:2581-90. 2011
    ..Based on these transcriptional data, we propose a new paradigm for the human immunological response to severe injury...
  7. doi Dexmedetomidine vs midazolam for sedation of critically ill patients: a randomized trial
    Richard R Riker
    University of Vermont College of Medicine, USA
    JAMA 301:489-99. 2009
    ..Gamma-aminobutyric acid receptor agonist medications are the most commonly used sedatives for intensive care unit (ICU) patients, yet preliminary evidence indicates that the alpha(2) agonist dexmedetomidine may have distinct advantages...
  8. doi Serum lactate is associated with mortality in severe sepsis independent of organ failure and shock
    Mark E Mikkelsen
    Pulmonary, Allergy, and Critical Care Division, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Crit Care Med 37:1670-7. 2009
    ..e., refractory hypotension)...
  9. ncbi Accuracy of procalcitonin for sepsis diagnosis in critically ill patients: systematic review and meta-analysis
    Benjamin M P Tang
    Department of Intensive Care Medicine, Nepean Hospital, Penrith, New South Wales, Australia
    Lancet Infect Dis 7:210-7. 2007
    ..The findings from this study do not lend support to the widespread use of the procalcitonin test in critical care settings...
  10. doi Early versus late parenteral nutrition in critically ill adults
    Michael P Casaer
    Department of Intensive Care Medicine, University Hospitals of the Catholic University of Leuven, Leuven, Belgium
    N Engl J Med 365:506-17. 2011
    ..Controversy exists about the timing of the initiation of parenteral nutrition in critically ill adults in whom caloric targets cannot be met by enteral nutrition alone...
  11. ncbi ESPEN Guidelines on Enteral Nutrition: Intensive care
    K G Kreymann
    Department of Intensive Care Medicine, University Hospital Eppendorf, Hamburg, Germany
    Clin Nutr 25:210-23. 2006
    ..During the acute and initial phases of critical illness an exogenous energy supply in excess of 20-25 kcal/kg BW/day should be avoided, whereas, during recovery, the ..
  12. ncbi Modified RIFLE criteria in critically ill children with acute kidney injury
    A Akcan-Arikan
    Renal Section, Department of Pediatrics, Baylor College of Medicine, Texas Children s Hospital, Houston, Texas 77030, USA
    Kidney Int 71:1028-35. 2007
    ..Acute kidney injury is associated with mortality and may lead to increased hospital costs. We suggest that the pRIFLE criteria serves to characterize the pattern of acute kidney injury in critically ill children...
  13. doi Consensus statement of the ESICM task force on colloid volume therapy in critically ill patients
    Konrad Reinhart
    Department for Anesthesiology and Intensive Care Medicine, Jena University Hospital, Friedrich Schiller University, Erlanger Allee 101, 07747 Jena, Germany
    Intensive Care Med 38:368-83. 2012
    ....
  14. doi Plasma and urine neutrophil gelatinase-associated lipocalin in septic versus non-septic acute kidney injury in critical illness
    Sean M Bagshaw
    Division of Critical Care Medicine, University of Alberta Hospital, University of Alberta, 3C1 16 Walter C Mackenzie Centre, 8440 122 Street, Edmonton, AB T6G2B7, Canada
    Intensive Care Med 36:452-61. 2010
    ..We sought to determine whether there are unique patterns to plasma and urine neutrophil gelatinase-associated lipocalin (NGAL) in septic compared with non-septic AKI...
  15. doi Decontamination of the digestive tract and oropharynx in ICU patients
    A M G A de Smet
    Division of Perioperative and Emergency Care, University Medical Center, Utrecht, The Netherlands
    N Engl J Med 360:20-31. 2009
    ....
  16. ncbi Clinical consequences of red cell storage in the critically ill
    Alan Tinmouth
    Center for Transfusion and Critical Care Research, Clinical Epidemiology Unit, Critical Care Program, University of Ottawa and Ottawa Health Research Institute, Ottawa, Ontario, Canada
    Transfusion 46:2014-27. 2006
    ..These data suggest a possible detrimental clinical effect associated with the transfusion of stored RBCs; randomized clinical trials further evaluating the clinical consequences of transfusing older stored RBCs are required...
  17. ncbi Efficacy and safety of corticosteroids for persistent acute respiratory distress syndrome
    Kenneth P Steinberg
    Division of Pulmonary and Critical Care Medicine, Harborview Medical Center, Box 359762, 325 Ninth Ave, Seattle, WA 98104, USA
    N Engl J Med 354:1671-84. 2006
    ..Because previous reports suggested that corticosteroids may improve survival, we performed a multicenter, randomized controlled trial of corticosteroids in patients with persistent ARDS...
  18. doi A protocol of no sedation for critically ill patients receiving mechanical ventilation: a randomised trial
    Thomas Strøm
    Department of Anesthesia and Intensive Care Medicine, Odense University Hospital, University of Southern Denmark, Denmark
    Lancet 375:475-80. 2010
    ..We aimed to establish whether duration of mechanical ventilation could be reduced with a protocol of no sedation versus daily interruption of sedation...
  19. doi Acute kidney injury in critically ill patients classified by AKIN versus RIFLE using the SAPS 3 database
    Michael Joannidis
    Intensive Care Unit, Department of Internal Medicine I, Medical University Innsbruck, Anichstrasse 35, 6020, Innsbruck, Austria
    Intensive Care Med 35:1692-702. 2009
    ..This study compares these two classification systems with regard to outcome...
  20. doi Critically Ill patients with 2009 influenza A(H1N1) in Mexico
    Guillermo Dominguez-Cherit
    Division of Pulmonary and Critical Care Dr Domínguez Cherit, Hospital Epidemiology Department, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, Mexico
    JAMA 302:1880-7. 2009
    In March 2009, novel 2009 influenza A(H1N1) was first reported in the southwestern United States and Mexico. The population and health care system in Mexico City experienced the first and greatest early burden of critical illness.
  21. pmc Reduced cortisol metabolism during critical illness
    Eva Boonen
    Clinical Division and Laboratory of Intensive Care Medicine, Department of Cellular and Molecular Medicine, KU Leuven, Leuven, Belgium
    N Engl J Med 368:1477-88. 2013
    b>Critical illness is often accompanied by hypercortisolemia, which has been attributed to stress-induced activation of the hypothalamic-pituitary-adrenal axis...
  22. ncbi Acute renal failure in critically ill patients: a multinational, multicenter study
    Shigehiko Uchino
    Department of Intensive Care, Austin Hospital, Melbourne, Australia
    JAMA 294:813-8. 2005
    Although acute renal failure (ARF) is believed to be common in the setting of critical illness and is associated with a high risk of death, little is known about its epidemiology and outcome or how these vary in different regions of the ..
  23. ncbi Predictive value of procalcitonin and interleukin 6 in critically ill patients with suspected sepsis
    Ville Pettila
    Department of Surgery, Division of Anesthesiology and Intensive Care Medicine, Helsinki University Hospital, P O Box 340, 00029 HUS, Helsinki, Finland
    Intensive Care Med 28:1220-5. 2002
    ....
  24. pmc Prognosis for long-term survival and renal recovery in critically ill patients with severe acute renal failure: a population-based study
    Sean M Bagshaw
    Department of Critical Care Medicine, Calgary Health Region, University of Calgary, Calgary, Alberta, Canada
    Crit Care 9:R700-9. 2005
    ..Severe acute renal failure (sARF) is associated with considerable morbidity, mortality and use of healthcare resources; however, its precise epidemiology and long-term outcomes have not been well described in a non-specified population...
  25. doi Ionized calcium concentration and outcome in critical illness
    Moritoki Egi
    Department of Anesthesiology and Resuscitology, Okayama University Hospital, Okayama, Japan
    Crit Care Med 39:314-21. 2011
    ..To assess the association of abnormalities of ionized calcium levels with mortality in a heterogeneous cohort of critically ill patients...
  26. ncbi Procalcitonin as a diagnostic test for sepsis in critically ill adults and after surgery or trauma: a systematic review and meta-analysis
    Bernard Uzzan
    APHP Laboratoire de Pharmacologie Hormonologie, Hopital Avicenne, Bobigny, France
    Crit Care Med 34:1996-2003. 2006
    ..To draw and compare the summary receiver operating characteristics curves for procalcitonin and C-reactive protein from the literature...
  27. ncbi Diagnostic and prognostic implications of endotoxemia in critical illness: results of the MEDIC study
    John C Marshall
    University Health Network, University of Toronto, Toronto, Ontario, Canada
    J Infect Dis 190:527-34. 2004
    ..Stepwise logistic regression analysis showed that elevated Acute Physiology and Chronic Health Evaluation II score, gram-negative infection, and emergency admission status were independent predictors of EA...
  28. pmc Delirium as a predictor of long-term cognitive impairment in survivors of critical illness
    Timothy D Girard
    Division of Allergy, Pulmonary, and Critical Care Medicine, Center for Health Services Research, Department of Medicine, Vanderbilt University School of Medicine, and Department of Medicine, Saint Thomas Hospital, Nashville, TN, USA
    Crit Care Med 38:1513-20. 2010
    To test the hypothesis that duration of delirium in the intensive care unit is an independent predictor of long-term cognitive impairment after critical illness requiring mechanical ventilation.
  29. ncbi Early use of the pulmonary artery catheter and outcomes in patients with shock and acute respiratory distress syndrome: a randomized controlled trial
    Christian Richard
    Service de Reanimation Medicale, Hopital de Bicetre, Le Kremlin Bicetre, France
    JAMA 290:2713-20. 2003
    ..Many physicians believe that the pulmonary artery catheter (PAC) is useful for the diagnosis and treatment of cardiopulmonary disturbances; however, observational studies suggest that its use may be harmful...
  30. pmc Intestinal crosstalk: a new paradigm for understanding the gut as the "motor" of critical illness
    Jessica A Clark
    Department of Surgery, Washington University School of Medicine, St Louis, Missouri, USA
    Shock 28:384-93. 2007
    ..Many of these disparate mechanisms have proved to be important in the origin and propagation of critical illness. However, this has led to an unusual situation where investigators describing the gut as a "motor" revving ..
  31. doi Fluid accumulation, survival and recovery of kidney function in critically ill patients with acute kidney injury
    Josee Bouchard
    Division of Nephrology and Hypertension, Department of Medicine, University of California San Diego, San Diego, California, USA
    Kidney Int 76:422-7. 2009
    ..Whether the fluid overload was the result of a more severe renal failure or it contributed to its cause will require clinical trials in which the role of fluid administration to such patients is directly tested...
  32. pmc Urine neutrophil gelatinase-associated lipocalin is an early marker of acute kidney injury in critically ill children: a prospective cohort study
    Michael Zappitelli
    Texas Children s Hospital, Fannin Street, Houston, Texas 77030, USA
    Crit Care 11:R84. 2007
    ..It is unknown whether uNGAL predicts AKI in the general critical care setting. We assessed the ability of uNGAL to predict AKI development and severity in critically ill children...
  33. doi Insulin resistance in critical illness
    Archana Dhar
    Division of Critical Care, Department of Pediatrics, Children s Medical Center, University of Texas Southwestern, Dallas, USA
    Curr Opin Pediatr 23:269-74. 2011
    ..Hence, a better understanding of these regulatory mechanisms and the alterations leading to dysfunction will set the basis for a better metabolic and immune support of critically ill patients...
  34. ncbi Invasive aspergillosis in critically ill patients without malignancy
    Wouter Meersseman
    Medical Intensive Care Unit, Department of General Internal Medicine, University Hospital, Leuven, Belgium
    Am J Respir Crit Care Med 170:621-5. 2004
    ..IA is an emerging and devastating infectious disease in patients in the ICU without malignancy. In those patients, host criteria for probable fungal infections should probably be adapted...
  35. pmc Critical illness from 2009 pandemic influenza A virus and bacterial coinfection in the United States
    Todd W Rice
    Vanderbilt University School of Medicine, Nashville, TN, USA
    Crit Care Med 40:1487-98. 2012
    The contribution of bacterial coinfection to critical illness associated with 2009 influenza A virus infection remains uncertain...
  36. pmc Gastrointestinal function in intensive care patients: terminology, definitions and management. Recommendations of the ESICM Working Group on Abdominal Problems
    Annika Reintam Blaser
    Clinic of Anaesthesiology and Intensive Care, University of Tartu, Puusepa 8, 51014 Tartu, Estonia
    Intensive Care Med 38:384-94. 2012
    ..An international working group convened to standardize the definitions for acute GI failure and GI symptoms and to review the therapeutic options...
  37. doi Evaluation of new acute kidney injury biomarkers in a mixed intensive care unit
    Kent Doi
    Department of Nephrology and Endocrinology, The University of Tokyo, Tokyo, Japan
    Crit Care Med 39:2464-9. 2011
    ..This study was undertaken to evaluate the reliability of new acute kidney injury biomarkers including urinary L-type fatty acid-binding protein with heterogeneous intensive care unit populations...
  38. doi Meropenem dosing in critically ill patients with sepsis and without renal dysfunction: intermittent bolus versus continuous administration? Monte Carlo dosing simulations and subcutaneous tissue distribution
    Jason A Roberts
    Burns, Trauma and Critical Care Research Centre, The University of Queensland, Brisbane, Australia
    J Antimicrob Chemother 64:142-50. 2009
    ....
  39. doi Permissive underfeeding and intensive insulin therapy in critically ill patients: a randomized controlled trial
    Yaseen M Arabi
    Department of Intensive Care Medicine, King Abdulaziz Medical City, King Saud Bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia
    Am J Clin Nutr 93:569-77. 2011
    ..Nutritional support has been recognized as an essential part of intensive care unit management. However, the appropriate caloric intake for critically ill patients remains ill defined...
  40. doi Patient and healthcare professional factors influencing end-of-life decision-making during critical illness: a systematic review
    David W Frost
    Division of General Internal Medicine, University Health Network, University of Toronto, Toronto, Ontario, Canada
    Crit Care Med 39:1174-89. 2011
    ..DATA SOURCES, SELECTION, AND ABSTRACTION: We conducted a structured search of Ovid Medline for interventional and observational research articles incorporating critical care and end-of-life decision-making terms...
  41. pmc Circulating soluble urokinase plasminogen activator receptor is stably elevated during the first week of treatment in the intensive care unit and predicts mortality in critically ill patients
    Alexander Koch
    Department of Medicine III, RWTH University Hospital Aachen, Pauwelsstrasse 30, 52074 Aachen, Germany
    Crit Care 15:R63. 2011
    ....
  42. pmc Informatics infrastructure for syndrome surveillance, decision support, reporting, and modeling of critical illness
    Vitaly Herasevich
    Division of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, MN 55905, USA
    Mayo Clin Proc 85:247-54. 2010
    To develop and validate an informatics infrastructure for syndrome surveillance, decision support, reporting, and modeling of critical illness.
  43. pmc Antibiotics in critically ill patients: a systematic review of the pharmacokinetics of β-lactams
    João Gonçalves-Pereira
    Polyvalent Intensive Care Unit, São Francisco Xavier Hospital, Estrada do Forte do Alto do Duque, 1449 005 Lisboa, Portugal
    Crit Care 15:R206. 2011
    ....
  44. ncbi Acute renal failure in patients with sepsis in a surgical ICU: predictive factors, incidence, comorbidity, and outcome
    Eric A J Hoste
    Intensive Care Unit and Renal Unit, Ghent University Hospital, Gent, Belgium
    J Am Soc Nephrol 14:1022-30. 2003
    ..This model allows initiating specific therapeutic measures earlier in the course of sepsis, hopefully resulting in a lower incidence of ARF and needi for RRT, thereby lowering mortality...
  45. pmc Circulating retinol binding protein 4 in critically ill patients before specific treatment: prognostic impact and correlation with organ function, metabolism and inflammation
    Alexander Koch
    Department of Medicine III, RWTH University Hospital Aachen, Pauwelsstrasse 30, 52074 Aachen, Germany
    Crit Care 14:R179. 2010
    Hyperglycemia and insulin resistance are well-known features of critical illness and impact the mortality rate, especially in sepsis...
  46. ncbi Passive leg raising predicts fluid responsiveness in the critically ill
    Xavier Monnet
    Service de Reanimation Medicale, Centre Hospitalier Universitaire de Bicetre, Assistance Publique Hopitaux de Paris, Université Paris 11, Le Kremlin Bicetre, France
    Crit Care Med 34:1402-7. 2006
    ..We hypothesized that the hemodynamic response to PLR predicts fluid responsiveness in mechanically ventilated patients...
  47. doi Acquired weakness, handgrip strength, and mortality in critically ill patients
    Naeem A Ali
    Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, Ohio State University, 473 W 12th Avenue, Columbus, OH 43221, USA
    Am J Respir Crit Care Med 178:261-8. 2008
    ICU-acquired paresis (ICUAP) is common in survivors of critical illness. There is significant associated morbidity, including prolonged time on the ventilator and longer hospital stay...
  48. doi Use of intravenous zanamivir after development of oseltamivir resistance in a critically Ill immunosuppressed child infected with 2009 pandemic influenza A (H1N1) virus
    Daniel E Dulek
    Departments of Pediatrics, Vanderbilt University School of Medicine and the Monroe Carell Jr Children s Hospital at Vanderbilt, Nashville, Tennessee, USA
    Clin Infect Dis 50:1493-6. 2010
    ..The regimen was well tolerated and was associated with a decrease in viral burden...
  49. pmc Regulation and prognostic relevance of serum ghrelin concentrations in critical illness and sepsis
    Alexander Koch
    Department of Medicine III, RWTH University Hospital Aachen, Pauwelsstrasse 30, 52074 Aachen, Germany
    Crit Care 14:R94. 2010
    ..possible pathogenic functions of ghrelin in critically ill patients and human sepsis from a clinical point of view, we aimed at analyzing ghrelin serum concentrations in a large cohort of well characterized patients with critical illness.
  50. doi Reduced heart rate multiscale entropy predicts death in critical illness: a study of physiologic complexity in 285 trauma patients
    Patrick R Norris
    Division of Trauma, Burn, and Surgical Critical Care, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    J Crit Care 23:399-405. 2008
    ..We hypothesized that heart rate multiscale entropy (MSE), a potential measurement of physiologic complexity, would predict death more robustly than HRVi...
  51. ncbi Should immunonutrition become routine in critically ill patients? A systematic review of the evidence
    D K Heyland
    Angada 3, Kingston General Hospital, 76 Stuart St, Kingston, Ontario K7L 2V7, Canada
    JAMA 286:944-53. 2001
    ..Several nutrients have been shown to influence immunologic and inflammatory responses in humans. Whether these effects translate into an improvement in clinical outcomes in critically ill patients remains unclear...
  52. ncbi C-reactive protein levels correlate with mortality and organ failure in critically ill patients
    Suzana M A Lobo
    Department of Intensive Care, Erasme Hospital, Free University of Brussels, Belgium
    Chest 123:2043-9. 2003
    ..This study assessed the association between early serum CRP concentrations and the development of organ failure and mortality in ICU patients...
  53. ncbi A multi-centre evaluation of the RIFLE criteria for early acute kidney injury in critically ill patients
    Sean M Bagshaw
    Division of Critical Care Medicine, University of Alberta Hospital, 3C1 16 Walter C Mackenzie Centre, 8440 122 Street, Edmonton, Alberta T6G2B7, Canada
    Nephrol Dial Transplant 23:1203-10. 2008
    ..We sought to evaluate the RIFLE criteria on the day of ICU admission in a large heterogenous population of critically ill patients...
  54. doi Monitoring the microcirculation in the critically ill patient: current methods and future approaches
    Daniel De Backer
    Department of Intensive Care, Erasme University Hospital, Universite Libre de Bruxelles, Route de Lennik 808, 1070, Brussels, Belgium
    Intensive Care Med 36:1813-25. 2010
    ..To discuss the techniques currently available to evaluate the microcirculation in critically ill patients. In addition, the most clinically relevant microcirculatory alterations will be discussed...
  55. pmc Cytomegalovirus reactivation in critically ill immunocompetent patients
    Ajit P Limaye
    Department of Laboratory Medicine, University of Washington Medical Center, 1959 NE Pacific St, Seattle, WA 98195 7110, USA
    JAMA 300:413-22. 2008
    ....
  56. pmc Broad-range bacterial detection and the analysis of unexplained death and critical illness
    Simo Nikkari
    Stanford University School of Medicine, California, USA
    Emerg Infect Dis 8:188-94. 2002
    ..initiated population-based surveillance for unexplained life-threatening infections (Unexplained Death and Critical Illness Project [UNEX])...
  57. ncbi Ischemic-like cholangiopathy with secondary sclerosing cholangitis in critically ill patients
    Cornelia M Gelbmann
    Department of Internal Medicine I and Institute of Pathology, University of Regensburg, Regensburg, Germany
    Am J Gastroenterol 102:1221-9. 2007
    ..The mechanisms leading to this form of cholangiopathy with stricture formation and complete obliteration of bile ducts are unknown...
  58. ncbi Serial evaluation of the SOFA score to predict outcome in critically ill patients
    F L Ferreira
    Department of Intensive Care, Erasme University Hospital, Route de Lennik, 808, B 1070 Brussels, Belgium
    JAMA 286:1754-8. 2001
    ..Evaluation of trends in organ dysfunction in critically ill patients may help predict outcome...
  59. ncbi The epidemiology of the systemic inflammatory response
    C Brun-Buisson
    Service de Réanimation Médicale and Unité d Hygiène et Prévention de L Infection, Hopital Henri Mondor, Assistance Publique Hôpitaux de Paris and Université Paris 12, Creteil, France
    Intensive Care Med 26:S64-74. 2000
    ....
  60. pmc Acute kidney injury in critically ill newborns: what do we know? What do we need to learn?
    David J Askenazi
    Division of Pediatric Nephrology, University of Alabama at Birmingham, 1600 7th Ave So, ACC 516, Birmingham, AL, 35233, USA
    Pediatr Nephrol 24:265-74. 2009
    ..Early biomarkers of AKI need to be explored in critically ill neonates. Infants with AKI need to be followed for sequelae after AKI...
  61. pmc Lactate versus non-lactate metabolic acidosis: a retrospective outcome evaluation of critically ill patients
    Kyle J Gunnerson
    Virginia Commonwealth University Reanimation Engineering Shock Center Laboratory, Department of Anesthesiology Critical Care, Medical College of Virginia Virginia Commonwealth University, 1200 East Broad Street, Richmond, VA 23298, USA
    Crit Care 10:R22. 2006
    ..The relative incidence of each type of disorder is unknown. We therefore designed this study to determine the nature and clinical significance of metabolic acidosis in critically ill patients...
  62. doi Early exercise in critically ill patients enhances short-term functional recovery
    Chris Burtin
    Faculty of Kinesiology and Rehabilitation Sciences CB, BC, CR, DL, TT, RG, Katholieke Universiteit Leuven, Leuven, Belgium
    Crit Care Med 37:2499-505. 2009
    ..No evidence is available concerning the effectiveness of an early exercise training intervention to prevent these detrimental complications...
  63. pmc Association between acute care and critical illness hospitalization and cognitive function in older adults
    William J Ehlenbach
    Department of Medicine, University of Washington, Seattle, USA
    JAMA 303:763-70. 2010
    Studies suggest that many survivors of critical illness experience long-term cognitive impairment but have not included premorbid measures of cognitive functioning and have not evaluated risk for dementia associated with critical illness.
  64. pmc Urinary cystatin C is diagnostic of acute kidney injury and sepsis, and predicts mortality in the intensive care unit
    Maryam Nejat
    Department of Medicine, University of Otago Christchurch, Riccarton Avenue, Christchurch 8140, New Zealand
    Crit Care 14:R85. 2010
    ..To evaluate the utility of urinary cystatin C (uCysC) as a diagnostic marker of acute kidney injury (AKI) and sepsis, and predictor of mortality in critically ill patients...
  65. pmc Evidence and consensus-based German guidelines for the management of analgesia, sedation and delirium in intensive care--short version
    JORG MARTIN
    Department of Anesthesiology and Operative Intensive Care, Klinik am Eichert, Goppingen, Germany
    Ger Med Sci 8:Doc02. 2010
    ..These guidelines offer treatment recommendations for the ICU team. The implementation of scores and protocols into routine ICU practice is necessary for their success...
  66. ncbi Caloric intake in medical ICU patients: consistency of care with guidelines and relationship to clinical outcomes
    Jerry A Krishnan
    Division of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
    Chest 124:297-305. 2003
    ..To assess the consistency of caloric intake with American College of Chest Physicians (ACCP) recommendations for critically ill patients and to evaluate the relationship of caloric intake with clinical outcomes...
  67. doi Corticosteroid treatment in critically ill patients with pandemic influenza A/H1N1 2009 infection: analytic strategy using propensity scores
    Sung Han Kim
    Department of Infectious Diseases, Asan Medical Center, University of Ulsan College of Medicine, 388 1 Pungnap dong, Songpa Gu, Seoul 138 736, Republic of Korea
    Am J Respir Crit Care Med 183:1207-14. 2011
    ..Administration of adjuvant corticosteroids to patients with pandemic influenza A/H1N1 2009 (pH1N1) may reduce inflammation and improve outcomes...
  68. doi Early enteral nutrition, provided within 24 h of injury or intensive care unit admission, significantly reduces mortality in critically ill patients: a meta-analysis of randomised controlled trials
    Gordon S Doig
    Northern Clinical School, University of Sydney, Sydney, 2006 NSW, Australia
    Intensive Care Med 35:2018-27. 2009
    ..To determine whether the provision of early standard enteral nutrition (EN) confers treatment benefits to critically ill patients...
  69. doi Gender impact on the outcomes of critically ill patients with nosocomial infections
    Alain Combes
    Service de Reanimation Medicale, Hopital Pitie Salpetriere, Assistance Publique Hopitaux de Paris, Universite Pierre et Marie Curie, Paris, France
    Crit Care Med 37:2506-11. 2009
    ..Highly controversial data exist regarding gender-related differences in outcomes of severe nosocomial infections, reflecting potential confounders related to case-mixes or heterogeneity of populations evaluated...
  70. ncbi Ultrasound diagnosis of alveolar consolidation in the critically ill
    Daniel A Lichtenstein
    Service de Reanimation Medicale, Hopital Ambroise Pare, 9 avenue du Général Charles de Gaulle, 92100 Boulogne Paris Ouest, France
    Intensive Care Med 30:276-81. 2004
    ..Radiography is not a precise tool, and referral to CT raises problems (transport, irradiation). The aim of this study was to assess the utility of ultrasound in the diagnosis of alveolar consolidation...
  71. ncbi Delirium and its motoric subtypes: a study of 614 critically ill patients
    Josh F Peterson
    Division of General Internal Medicine, Center for Health Services Research, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    J Am Geriatr Soc 54:479-84. 2006
    ..To describe the motoric subtypes of delirium in critically ill patients and compare patients aged 65 and older with a younger cohort...
  72. pmc Long-term cognitive impairment after critical illness
    P P Pandharipande
    Department of Anesthesiology, Division of Critical Care, Vanderbilt University School of Medicine, Nashville, USA
    N Engl J Med 369:1306-16. 2013
    Survivors of critical illness often have a prolonged and disabling form of cognitive impairment that remains inadequately characterized.
  73. ncbi Circulating nucleic acids and critical illness
    Timothy H Rainer
    Accident and Emergency Medicine Academic Unit, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong SAR
    Ann N Y Acad Sci 1075:271-7. 2006
    ..Circulating nucleic acids may be useful markers for the evaluation and risk-stratification of such patients...
  74. doi Role of dimethylarginine dimethylaminohydrolase activity in regulation of tissue and plasma concentrations of asymmetric dimethylarginine in an animal model of prolonged critical illness
    Mariska Davids
    Metabolic Laboratory, Department of Clinical Chemistry, VU University Medical Center, PO Box 7057, 1007MB Amsterdam, The Netherlands
    Metabolism 61:482-90. 2012
    ..In critical illness, plasma ADMA poorly reflects intracellular ADMA...
  75. pmc Survival in critical illness is associated with early activation of mitochondrial biogenesis
    Jane E Carré
    Bloomsbury Institute for Intensive Care Medicine, Department of Medicine and Wolfson Institute of Biomedical Research, University College London, London, United Kingdom
    Am J Respir Crit Care Med 182:745-51. 2010
    ..We postulate that survivors have a greater ability to maintain or recover normal mitochondrial functionality...
  76. doi Developing the Children's Critical Illness Impact Scale: capturing stories from children, parents, and staff
    Janet E Rennick
    Department of Nursing Research, The Montreal Children s Hospital of the McGill University Health Centre, School of Nursing, McGill University, Montreal, Quebec, Canada H3H 1P3
    Pediatr Crit Care Med 9:252-60. 2008
    ..The purpose of this study was to develop a measure of posthospitalization distress, the Children's Critical Illness Impact Scale (CCIIS), for children aged 6-12 yrs following pediatric intensive care unit hospitalization.
  77. pmc Improved performance of urinary biomarkers of acute kidney injury in the critically ill by stratification for injury duration and baseline renal function
    Zoltan H Endre
    Department of Medicine, Christchurch Kidney Research Group, University of Otago, Christchurch, New Zealand
    Kidney Int 79:1119-30. 2011
    ..68 and 0.78. Beyond 12 h, NGAL (0.71) and KIM-1 (0.66) performed best. Thus, the duration of injury and baseline renal function should be considered in evaluating biomarker performance to diagnose AKI...
  78. ncbi Autophagy is increased in mice after traumatic brain injury and is detectable in human brain after trauma and critical illness
    Robert S B Clark
    Department of Critical Care Medicine, The Safar Center for Resuscitation Research and the Brain Trauma Research Center, Pittsburgh, Pennsylvania 15260, USA
    Autophagy 4:88-90. 2008
    ..Taken together, we show that autophagy occurs after both experimental and clinical TBI, and that oxidative stress contributes to overall neuropathology after TBI in mice, at least in part by initiating or influencing autophagy...
  79. pmc Intracardiac origin of heart rate variability, pacemaker funny current and their possible association with critical illness
    Vasilios E Papaioannou
    Democritus University of Thrace, Alexandroupolis University Hospital, Intensive Care Unit, Alexandroupolis Medical School, Dragana 68100, Greece
    Curr Cardiol Rev 9:82-96. 2013
    ..HRV) is an indirect estimator of autonomic modulation of heart rate and is considered a risk marker in critical illness, particularly in heart failure and severe sepsis...
  80. ncbi Short-term prognosis in critically ill patients with cirrhosis assessed by prognostic scoring systems
    M Wehler
    Department of Medicine I and Medical Informatics, University of Erlangen Nuremberg, Germany
    Hepatology 34:255-61. 2001
    ..The SOFA is an easily applied tool with excellent prognostic abilities and can be used to enhance clinical judgment of prognosis as well as providing patients and families with objective information...
  81. doi Fluid resuscitation with 6% hydroxyethyl starch (130/0.4) in acutely ill patients: an updated systematic review and meta-analysis
    David J Gattas
    Critical Care and Trauma Division, The George Institute for Global Health, University of Sydney, Australia
    Anesth Analg 114:159-69. 2012
    ..4 is one of the most frequently used resuscitation fluids worldwide. The retraction of studies evaluating its use necessitates a reevaluation of available evidence regarding its safety and efficacy...
  82. ncbi Clinical utility of standard base excess in the diagnosis and interpretation of metabolic acidosis in critically ill patients
    M Park
    Departamento de Emergencia, Unidade de Terapia Intensiva, Universidade de Sao Paulo, Brasil
    Braz J Med Biol Res 41:241-9. 2008
    ..To analyze the components of SBE VS shifts at the bedside, AG A, apparent strong ion difference, albumin level, and lactate concentration are easily measurable variables that best represent the partitioning of acid-base derangements...
  83. pmc Biomarker discovery and development in pediatric critical care medicine
    Jennifer M Kaplan
    Division of Critical Care Medicine, Cincinnati Children s Hospital Medical Center and Cincinnati Children s Research Foundation, University of Cincinnati College of Medicine, Cincinnati, OH, USA
    Pediatr Crit Care Med 12:165-73. 2011
    ..To frame the general process of biomarker discovery and development; and to describe a proposal for the development of a multibiomarker-based risk model for pediatric septic shock...
  84. ncbi Early signs of critical illness polyneuropathy in ICU patients with systemic inflammatory response syndrome or sepsis
    A Tennilä
    Department of Anaesthesia and Intensive Care, Helsinki University Hospital, Finland
    Intensive Care Med 26:1360-3. 2000
    ..To evaluate with electromyography the incidence and the time of appearance of neuromuscular abnormality in patients with systemic inflammatory response syndrome (SIRS) and/or sepsis...
  85. doi Pro- and synbiotics to control inflammation and infection in patients with multiple injuries
    Evangelos J Giamarellos-Bourboulis
    4th Department of Internal Medicine, University of Athens, Medical School, Athens, Greece
    J Trauma 67:815-21. 2009
    ..The mechanism of action of synbiotics was studied...
  86. doi The impact of comorbid [corrected] conditions on critical illness
    Annette M Esper
    Division of Pulmonary, Allergy and Critical Care, Emory University School of Medicine, Atlanta, GA, USA
    Crit Care Med 39:2728-35. 2011
    ....
  87. doi Acetyl salicylic acid usage and mortality in critically ill patients with the systemic inflammatory response syndrome and sepsis
    Damon P Eisen
    Victorian Infectious Diseases Service, Royal Melbourne Hospital, Parkville, Victoria, Australia
    Crit Care Med 40:1761-7. 2012
    ..We sought to determine whether acetyl salicylic acid administration at the time of development of systemic inflammatory response syndrome is associated with reduced mortality...
  88. pmc ICU-acquired weakness: what is preventing its rehabilitation in critically ill patients?
    Christie M Lee
    Interdepartmental Division of Critical Care Medicine, University of Toronto, and the Division of Respirology, Department of Medicine, Mount Sinai Hospital and University Health Network, Toronto, Ontario, Canada
    BMC Med 10:115. 2012
    ..weakness (ICUAW) has been recognized as an important and persistent complication in survivors of critical illness. The absence of a consistent nomenclature and diagnostic criteria for ICUAW has made research in this area ..
  89. doi Serum adiponectin upon admission to the intensive care unit may predict mortality in critically ill patients
    Alexander Koch
    Department of Medicine III, RWTH University Hospital Aachen, Pauwelsstrasse 30, 52074 Aachen, Germany
    J Crit Care 26:166-74. 2011
    ..We therefore investigated the potential pathogenic role and prognostic value of circulating adiponectin levels in critical illness.
  90. pmc Sepsis is a major determinant of outcome in critically ill HIV/AIDS patients
    Andre M Japiassu
    Intensive Care Unit, Instituto de Pesquisa Clinica Evandro Chagas, Fundacao Oswaldo Cruz, Av Brasil 4365, Rio de Janeiro, Brazil
    Crit Care 14:R152. 2010
    ..We prospectively followed up critically ill HIV/AIDS patients to evaluate the main risk factors for hospital mortality and the impact of severe sepsis on the short- and long-term survival...
  91. pmc Serum neutrophil gelatinase-associated lipocalin at inception of renal replacement therapy predicts survival in critically ill patients with acute kidney injury
    Philipp Kümpers
    Department of Nephrology and Hypertension, Hannover Medical School, Carl Neuberg Strasse 1, D 30625, Hannover, Germany
    Crit Care 14:R9. 2010
    ..The aim of this study was to evaluate the predictive value of serum NGAL in patients with established AKI at inception of RRT in the intensive care unit (ICU)...
  92. ncbi Does enteral nutrition compared to parenteral nutrition result in better outcomes in critically ill adult patients? A systematic review of the literature
    Leah Gramlich
    Department of Medicine, University of Alberta, Edmonton, Alberta, Canada
    Nutrition 20:843-8. 2004
    ..Because EN and PN are associated with risks and benefits, we systematically reviewed and critically appraised the literature to compare EN with PN the critically ill patient...
  93. doi Is hyperchloremia associated with mortality in critically ill patients? A prospective cohort study
    Márcio M Boniatti
    Critical Care Department, Hospital de Clinicas de Porto Alegre, Brazil
    J Crit Care 26:175-9. 2011
    ..The aim of the study was to determine if acid-base variables are associated with hospital mortality...
  94. pmc Elevated urinary IL-18 levels at the time of ICU admission predict adverse clinical outcomes
    Edward D Siew
    Division of Nephrology, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    Clin J Am Soc Nephrol 5:1497-505. 2010
    ..Its ability to predict AKI and provide prognostic information in broadly selected, critically ill adults remains unknown...
  95. doi Pathways mediating resolution of inflammation: when enough is too much
    James N Fullerton
    Centre for Clinical Pharmacology, Division of Medicine, University College London, London, UK
    J Pathol 231:8-20. 2013
    Patients with critical illness, and in particular sepsis, are now recognized to undergo unifying, pathogenic disturbances of immune function...
  96. doi Mechanisms underlying the sparing of masticatory versus limb muscle function in an experimental critical illness model
    Sudhakar Aare
    Department of Neuroscience, Clinical Neurophysiology, Uppsala University, Uppsala, Sweden
    Physiol Genomics 43:1334-50. 2011
    ..spinal nerve innervated muscles during exposure to the ICU intervention...
  97. doi High-dose selenium substitution in sepsis: a prospective randomized clinical trial
    Jiri Valenta
    Department of Anaesthesiology, Resuscitation and Intensive Care, Charles University in Prague, Prague 2, Czech Republic
    Intensive Care Med 37:808-15. 2011
    ..Se supplementation in septic patients have yielded conflicting results. We hypothesized that a high-dose Se supplementation would (1) improve markers of inflammation, nutrition and antioxidant defence, and (2) decrease mortality...
  98. doi Worldwide demand for critical care
    Neill K J Adhikari
    Department of Critical Care Medicine, Sunnybrook Health Sciences Centre and Interdepartmental Division of Critical Care, University of Toronto, Toronto, Ontario, Canada
    Curr Opin Crit Care 17:620-5. 2011
    Interest in the global burden of critical illness is growing, but comprehensive data to describe this burden and the resources available to provide care for critically ill patients are lacking.
  99. doi Microcirculatory effects of intravenous fluids in critical illness: plasma expansion beyond crystalloids and colloids
    Nivaldo R Villela
    Laboratory for Clinical and Experimental Research in Vascular Biology, Biomedical Center, Universidade do Estado do Rio de Janeiro, Brazil
    Curr Opin Anaesthesiol 22:163-7. 2009
    ....
  100. pmc Prolonged mechanical ventilation in critically ill patients: epidemiology, outcomes and modelling the potential cost consequences of establishing a regional weaning unit
    Nazir I Lone
    Centre for Population Health Sciences, University of Edinburgh, Old Medical School, Teviot Place, Edinburgh, EH8 9AG, UK
    Crit Care 15:R102. 2011
    ..The aim of this study was to establish the incidence and outcomes of PMV in a UK administrative health care region without a dedicated weaning unit, and model the potential impact of establishing a dedicated weaning unit...
  101. doi The frequency and clinical significance of thrombocytopenia complicating critical illness: a systematic review
    Phil Hui
    Department of Medicine, McMaster University, Hamilton, ON, Canada
    Chest 139:271-8. 2011
    ..The objective of this study was to systematically review the prevalence, incidence, and consequences of, and risk factors for, thrombocytopenia among critically ill patients...

Research Grants83

  1. Bone Deficits and Excess Adiposity after Pediatric Bone Marrow Transplantation
    Sogol Mostoufi-Moab; Fiscal Year: 2013
    ....
  2. Cerebral metabolism, EEG, and sleep cycling in critically ill neonates
    Renée A Shellhaas; Fiscal Year: 2013
    ..abstract_text> ..
  3. Diagnosis of Subglottic Stenosis and Edema in Neonates Using OCT
    Brian Wong; Fiscal Year: 2013
    ..Development of an office-based treatment technology to diagnosis subglottic stenosis or monitor its development would reduce the need for morbidity and decrease health care costs. ..
  4. X chromosome, injury and infection
    Zoltan Spolarics; Fiscal Year: 2012
    ..Better understanding of the protecting cellular mechanisms that are in effect during septic conditions could lead to advanced protocols in treating the critically ill. ..
  5. Mechanisms of innate immune response modulation by mechanical ventilation
    William A Altemeier; Fiscal Year: 2012
    ..This project will help identify mechanisms by which mechanical ventilation support causes lung injury;thereby, providing guidance for the development of future interventions to decrease the incidence and severity of acute lung injury. ..
  6. Biofilm Infections in Postsurgical, Trauma, and Critically Ill Patients
    Carol L Wells; Fiscal Year: 2013
    ..This project has the potential to fundamentally change our understanding of the initiation, development, and treatment of biofilm infections. ..
  7. Genetic Epidemiology of Life-Threatening Influenza Infection in Children
    Adrienne Randolph; Fiscal Year: 2009
    ..abstract_text> ..
  8. Pathogenic Mechanisms of PBEF in Ventilator Induced Lung Injury
    Joe G N Garcia; Fiscal Year: 2012
    ..Using a systems biology-like approach (genes to populations), we have identified PBEF as a novel biomarker and candidate gene in ALI with genetic variants associated with sepsis and ALI susceptibility ..
  9. Monitoring of Cardiovascular Function in Infants By Transcutaneous Dye Dilution
    Istvan Seri; Fiscal Year: 2013
    ....
  10. Regulation of Innate Immunity by the Sympathetic Nervous System Druing Sepsis
    Eric J Seeley; Fiscal Year: 2013
    ..Lastly, these studies may shed light on how chronic physiologic or psychologic stress alter susceptibility to infection. ..
  11. Effect of Prone Position on Ventilator-Induced Lung Injury
    Guido Musch; Fiscal Year: 2013
    ..In this research, we will test whether promoting uniform lung inflation and tidal expansion by prone positioning reduces neutrophil metabolic activation, an early and important event in the pathogenesis of VILI. ..
  12. Immediate and Delayed Effects of Morphine on Brain Circuits: Animal and Human Cor
    Dusica Bajic; Fiscal Year: 2013
    ..Each of these laboratories has a well-established track record in scientific investigation relevant to the hypothesis and specific aims of the proposed study. ..
  13. Routine Aspiration of Residual Gastric Contents in Very Low Birth Weight Infants
    Leslie A Parker; Fiscal Year: 2013
    ..Public Health Relevance: This research has potential to influence health policy and practices that may directly translate to improved nutritional and health outcomes for premature VLBW infants. ..
  14. Phase III Study Comparing Albumin and Hetastarch Therapy in Acute Lung Injury
    Gregory S Martin; Fiscal Year: 2013
    ..This trial will also provide requisite data for any subsequent clinical trials targeted at other clinically relevant outcomes, such as mortality, the duration of mechanical ventilation, or health-related quality of life. ..
  15. Route of Nutrition and Enteric Nervous System Effects on Innate Mucosal Defense
    Kenneth A Kudsk; Fiscal Year: 2013
    ..We expect these studies will provide advances in our understanding of mucosal defenses and be highly relevant to critically injured and critically ill Veterans. ..
  16. Sepsis Outcomes and Aging: Role of Sleep Disruption and the Blood Brain Barrier
    Mark R Opp; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The factors by which aging predisposes to critical illness are varied, complex, and not well understood...
  17. Regulation of Intestinal Epithelial Tight Junction Barrier
    Thomas Y Ma; Fiscal Year: 2011
    ..The purpose of this grant application is to elucidate the pathogenic mechanisms involved in bacterial antigen induced disruption of intestinal barrier (or development of leaky gut). ..
  18. Syk in Mitochondrial Stress Signaling and Insulin Resistance
    Heide Christine Patterson; Fiscal Year: 2013
    ..production of excessive reactive oxygen species (ROS) released by dysfunctional mitochondria, ranging from critical illness to chronic conditions such as diabetes...
  19. RESEARCH TRAINING IN RESPIRATORY BIOLOGY
    Anne I Sperling; Fiscal Year: 2013
    ..Studies in Critical Illness continue to address subcellular determinants of oxygen sensing and consumption, cellular responses to hypoxia,..
  20. Hepatocyte Nitric Oxide Synthase Regulation by Glucagon and Insulin
    Brian G Harbrecht; Fiscal Year: 2012
    ..By defining these mechanisms, we will provide a framework for understanding the basic cellular events in shock and sepsis, which may lead to novel cellular-based therapies for critically ill patients. ..
  21. Trauma and Hemorrhage-Induced Skeletal Muscle Insulin Resistance
    JOSEPH LOUIS MESSINA; Fiscal Year: 2013
    ..that intensive insulin treatment of ICU patients may reduce both morbidity and mortality associated with critical illness. However, there is some controversy concerning the proper use of intensive insulin therapy, and under what ..
  22. Genetic Epidemiology of Life-Threatening Influenza in Children
    Adrienne G Randolph; Fiscal Year: 2013
    ..Understanding of the role of the innate immune and inflammatory response in children with life-threatening and fatal influenza infection could provide new targets for future preventive (immune adjuvant) and therapeutic approaches. ..
  23. Factors Associated with Ventilator-Associated Pneumonia Guideline Adherence
    Hiroko Kiyoshi-Teo; Fiscal Year: 2011
    ..As patient safety is a critically important topic for any country, I hope to contribute to the international healthcare communities through research, education, publication, and service. ..
  24. TREM-1 in Lung Immune Response
    Ruxana T Sadikot; Fiscal Year: 2013
    ..aeruginosa. ..
  25. Molecular Basis for Priming of the Neutrophil NADPH Oxidase in Trauma and Sepsis
    ALBERT T HSU; Fiscal Year: 2010
    ..In regards to public health, the overall goal of this research project is to reduce morbidity and mortality from MOSF in Surgical Intensive Care Units. ..
  26. Mechanisms of Renoprotection by Soluble Epoxide Hydrolase Inhibition
    Deanna L Kroetz; Fiscal Year: 2013
    ..The studies proposed in this application will explore a novel pathway for protection against acute kidney injury which exploits an abundant renal fatty acid epoxide with established roles in inflammation and apoptosis. ..
  27. HALF-PINT: Heart and Lung Failure - Pediatric INsulin Titration trial - CCC
    Vinay M Nadkarni; Fiscal Year: 2013
    ....
  28. Coagulation and Fibrinolysis in Pediatric Insulin Titration Trial
    Anil Sapru; Fiscal Year: 2013
    ..The results from this ancillary study will help us to understand potential mechanisms through which normalizing blood glucose provides benefit, which may lead to development of new therapeutic strategies in critically ill children ..
  29. 1st Tier Drugs+Theophylline in Pediatric Severe Asthma
    JERRY JOHN ZIMMERMAN; Fiscal Year: 2010
    ....
  30. Harmful effects of transfusion of older stored red cells: iron and inflammation
    Steven L Spitalnik; Fiscal Year: 2012
    ....
  31. The MIND USA Study
    E Wesley Ely; Fiscal Year: 2012
    ..This investigation will determine if either haloperidol or ziprasidone shorten delirium duration, improve survival, affect length of stay in the hospital, or improve long-term brain function and quality of life at 1-year follow-up. ..
  32. Testing the feasibility of patient-controlled sedation in ventilated ICU patients
    Craig R Weinert; Fiscal Year: 2013
    ..g., critical illness requiring MV)...
  33. Pharmaconutrients as Therapies for Critical Illness: Zinc in Severe Sepsis
    Renee D Stapleton; Fiscal Year: 2013
    ..on nutrition and pharmaconutrients in critically ill patients with sepsis, a syndrome that is common in critical illness and has an enormous public health impact. Dr...
  34. A novel treatment, TAT-HSP70, in attenuating lung injury in sepsis induced ARDS
    MARY MELANIE LYONS; Fiscal Year: 2012
    ..However, use of exogenous respiratory support compounds immobility, muscular deconditioning, and critical illness polyneuropathy (CIP) that almost universally develop in patients with sepsis...
  35. Prompt Diagnosis and Treatment of Subclinical Seizures After Cardiac Arrest
    Alexis A Topjian; Fiscal Year: 2013
    ....
  36. HALF-PINT: Heart And Lung Failure - Pediatric INsulin Titration trial - DCC
    David Wypij; Fiscal Year: 2013
    ....
  37. Mechanisms of diaphragm muscle dysfunction in critical-illness myopathy
    CATHERINE S SASSOON; Fiscal Year: 2012
    ..The study has the potential to stimulate developments of drugs to ameliorate or prevent acquired muscle weakness. ..
  38. Innate immune suppression following experimental injury
    KRISTIN C GREATHOUSE; Fiscal Year: 2012
    ..Studies have shown that critical illness can induce a clinically significant form of innate immune suppression that increases susceptibility to NI...
  39. Counter-Regulatory Lipid Mediators in Lung Disease
    Bruce D Levy; Fiscal Year: 2012
    ..To date, anti- inflammatory agents have not proven effective in reducing the associated critical illness, mortality and prolonged disability in ARDS survivors. Novel therapeutic approaches are needed...
  40. Humanization of a mouse anti-OX40 monoclonal antibody to treat cancer
    Andrew D Weinberg; Fiscal Year: 2012
    ..Agonox is proposing to genetically engineer the mouse antibody to become more "human" so that several rounds of treatment may be administered in order to achieve an even better outcome for cancer patients in future clinical trials. ..
  41. GM-CSF for Immunomodulation Following Trauma (GIFT) Trial
    Mark W Hall; Fiscal Year: 2013
    ..Our pediatric preliminary data, along with several small adult studies, suggest that GM-CSF can reverse critical illness-induced immunodepression...
  42. Mechanism of Heat Shock Protein Induction by Glutamine
    Paul E Wischmeyer; Fiscal Year: 2012
    ..Further, enhanced HSP expression improves survival in experimental models of critical illness. However, these findings have not been applied in a clinical setting, as laboratory inducers of HSPs are not ..
  43. TRH REGULATION/BIOSYNTHESIS AND PARAVENTRICULAR NUCLEUS
    RONALD MICHAEL LECHAN; Fiscal Year: 2010
    ..levels of thyroid hormone under normal conditions and during special circumstances such as fasting and critical illness when changes in thyroid status are required for adaptation...
  44. The Impact of Zinc on Innate Immunity and Patient Safety in Sepsis
    BETH YVONNE BESECKER; Fiscal Year: 2013
    ..and function to phagocytosis Aim 2: Determine the safety and toxicity profile of zinc supplementation over a range that may impact plasma zinc status, bacterial phagocytosis, and inflammatory balance in patients with severe sepsis ..
  45. A Model-integrated, Guideline-driven Process Management System for Sepsis
    Arthur P Wheeler; Fiscal Year: 2010
    ....
  46. MetaOx, Optical Monitor of Metabolic Rate of Oxygen Consumption
    BENIAMINO BARBIERI; Fiscal Year: 2013
    ..Daniel Licht). If the plan is accepted in its entirety, we expect to complete development of the FDNIRS/DCS system, which we call MetaOx, within the projected four-year period. ..
  47. Glycemic control in pediatric critical illness: The Ped-E-Trol trial
    MARK RANSFORD RIGBY; Fiscal Year: 2011
    DESCRIPTION (provided by applicant): Hyperglycemia during critical illness is an independent risk factor for increased morbidity and mortality in adults and children, and tight glycemic control improves clinical outcomes in some adult ..
  48. In Silico Model for Acute Lung Injury Prediction and Clinical Trial Design
    Ognjen Gajic; Fiscal Year: 2010
    ..The benefit of this methodology will be evaluated by comparing our model's prediction against the US Critical Illness and Injury Trials Group-Lung Injury Prediction Study...
  49. Collaborative Pediatric Critical Care Research Network At Children's Hospital of
    Joseph A Carcillo; Fiscal Year: 2013
    ..Our principal study during this time was the Critical Illness Stress Induced Immune Suppression Trial which tests the ability of a prophylaxis strategy to prevent stress ..
  50. Parenteral Methionine Requirements in Septic Children
    Leticia Castillo; Fiscal Year: 2013
    ..The sulfur amino acids methionine and cysteine are important in critical illness due to methionine role as a methyl group donor for creatine, choline and DNA methylation, and as the ..
  51. Preservation of mucosal barrier in surgical diseases
    Xiao Di Tan; Fiscal Year: 2013
    ..Our studies will ultimately lead to development of novel strategies for management and treatment of intestinal injury in critically ill patients. ..
  52. Targeting Myofibroblast for Intestinal Epithelial Regeneration
    Hongmiao Sheng; Fiscal Year: 2010
    ..The present project attempts to understand the molecular mechanisms governing intestinal regeneration and develop a novel therapeutic strategy for improving the integrity and function of the gut. ..
  53. Protocolized Care for Early Septic Shock (ProCESS)
    Derek C Angus; Fiscal Year: 2012
    ..nih.gov). ..
  54. Biomarkers of Vasospasm and Outcome following Subarachnoid Hemorrhage
    Sherry Hsiang Yi Chou; Fiscal Year: 2013
    ..interactions with cytokines, plasma gelsolin, and actin - molecules that mediate inflammatory reaction in critical illness such as SAH...
  55. Identification and Significance of Biologic Mediators in Red Cell Concentrates
    Richard P Phipps; Fiscal Year: 2012
    ..Our research will discover explanations for these effects, and we will devise inexpensive strategies to reduce these complications ..
  56. Contribution of the LDL receptor-related protein (LRP) to inflammation and sepsis
    Eric A Williams; Fiscal Year: 2010
    ....
  57. Potential of ICU telemedicine to improve patient safety, reduce morbidity & morta
    JAMES A L MATHERS; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Critical illness represents an enormous clinical and financial burden on the United States Health care system...
  58. Late cardiovascular consequences of septic shock
    Sachin Yende; Fiscal Year: 2013
    ..sepsis will continue to increase with the rising incidence of sepsis and reduced short-term mortality after critical illness. An acute cardiovascular event, such as acute myocardial infarction and stroke, is an important long-term ..
  59. GH Receptor Proteolysis and Shedding
    Stuart J Frank; Fiscal Year: 2013
    ..Both forms of regulation contribute to GH sensitivity and energy homeostasis in the steady state. 2) Critical illness, exemplified by sepsis, acutely desensitizes the liver to GH via TACE- mediated GHR proteolysis...
  60. Early Insulin Therapy and Development of ARDS
    Michelle Ng Gong; Fiscal Year: 2011
    ..ill patients with prolonged intensive care unit (ICU) stays, but the utility of NT to protect against early critical illness events such as ALI/ARDS is unknown...
  61. HIGH-DOSE VITAMIN D AND ANTIMICROBIAL PEPTIDE EXPRESSION IN LUNG FAILURE
    Thomas R Ziegler; Fiscal Year: 2012
    ..will be valuable to inform future investigations of vitamin D therapy and clinical outcomes in adult critical illness. Adequate vitamin D status is critical for the production of the endogenous antimicrobial peptide (AMP) LL-37 ..
  62. Allogeneic Human Mesenchymal Stem Cells for the Treatment of Acute Lung Injury
    Michael A Matthay; Fiscal Year: 2013
    ....
  63. C/EBP and IL-6 Production in Mucosa and Enterocytes
    Per Olof Hasselgren; Fiscal Year: 2006
    ..In addition, IL-6 may increase intestinal permeability in critical illness and IL-6 released from the gut may have systemic effects...
  64. Detection of Antibiotic Resistance Genes in Bacterial Agents of Hospital-Acquired
    Andrew Levin; Fiscal Year: 2009
    ....
  65. Feasibility of Measuring Sleep in a Critical Care Environment
    Margaret A Pisani; Fiscal Year: 2010
    ..immune function, glucose metabolism and cognitive function, all of which may contribute to poor outcomes from critical illness. More importantly sleep is a potentially modifiable factor in the intensive care unit...
  66. Coaxial Everting Membrane Catheter Bronchoalveolar Lavag
    William Krause; Fiscal Year: 2006
    ..The proposed device will provide for the uncontaminated sampling of the lower lung aspirate for a more accurate diagnosis of the organism causing the pneumonia. [unreadable] [unreadable] [unreadable]..
  67. Genomic analysis of pediatric SIRS and septic shock
    Hector Wong; Fiscal Year: 2009
    ..Child health will be positively impacted by developing the capability of conducting zinc supplementation trials in a safe and rigorous manner. ..
  68. Dose of Early Therapeutic Mobility: Does Type or Frequency of Activity Matter?
    Chris Winkelman; Fiscal Year: 2010
    ..been recommended to facilitate recovery and improve outcomes, particularly for the one million survivors of critical illness. The effective dose (i.e...
  69. Clinical Research to Bedside Care: Evidence and Tools for Improving Critical Care
    Gregory J Beilman; Fiscal Year: 2010
    ....
  70. SURGERY AND IV NUTRITION MODULATE MACROPHAGE FUNCTION
    W Helton; Fiscal Year: 1999
    ..and catabolic response which may contribute to multiple organ failure and increased mortality during surgical critical illness. The roles that the macrophage (Mphi) sympathetic and hypothalamic- pituitary-adrenal axis play in mediating ..
  71. Efficacy of Healing Touch in Stressed Neonates
    Sharon McDonough Means; Fiscal Year: 2002
    ..This study will begin our research in enhancement of neonatal regulatory system development and response to stress and will lay a foundation for larger scale prospective effectiveness and mechanism studies. ..
  72. The Critical Role of Bile Salts:Gut Protection in Critical Illness
    Eric Strauch; Fiscal Year: 2009
    ..Short gut syndrome results from a variety of pathologies leading to death and lifelong impairment of organ function, need of IV nutrition and intestinal transplant. ..
  73. Effect of cysteine on glutathione production in critically ill neonates
    STEPHEN SHEW; Fiscal Year: 2010
    ..The result of this investigation could ultimately change the standard nutritional and treatment practices for critically ill neonates in order to improve the outcome for these extremely fragile patients. ..
  74. Advanced Computational Framework for Decision Support in Critically Ill Children
    Randall C Wetzel; Fiscal Year: 2010
    ..and presentation as meaningful comparative metrics that adequately characterize the time-based continuum of critical illness. Analytics can then be developed and algorithms refined that can be applied to severity of illness, ..
  75. Advancing Patient Call Light Systems to Achieve Better Outcomes
    Huey Ming Tzeng; Fiscal Year: 2010
    ....
  76. NUTRITION AND DRUGS REDUCE PROTEIN LOSS IN SEPSIS
    ROLAND DICKERSON; Fiscal Year: 1992
    The long term objective of this program is to identify certain drugs that reduce the catabolic response to critical illness and ultimately, reduce patient morbidity and mortality...
  77. TRAUMA & ORGAN FAILURE--ROLE OF LPS BINDING PROTEIN
    Stewart Wang; Fiscal Year: 2000
    ..This information will provide important and previously unavailable insights into post-traumatic responses to Gram-negative sepsis and endotoxemia. ..
  78. The heat shock response and cytoprotection
    Hector Wong; Fiscal Year: 2006
    ..Induction of the HSR confers protection in animal models of critical illness, and understanding the mechanisms of this protective effect remains our focus of investigation...
  79. Sedation and Psychopharmacology in Critical care
    Marjolein de Wit; Fiscal Year: 2007
    ..Psychiatric morbidity will be assessed by administration of validated questionnaires. This study design creates a pathway for new understanding of the impact of sedation and the incidence of morbidity. ..
  80. Facial Expression During Pain
    MAMOONA ARIF; Fiscal Year: 2009
    ..This study will evaluate the type of facial expressions seen in these patients to improve nursing assessment and management of pain. ..
  81. NIRS Optical Topography System - Hitachi ETG-4000
    Allan Reiss; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  82. Sp1 As a Novel Protective Mechanism Against Septic inflammation And Organ Injury.
    Shu Fang Liu; Fiscal Year: 2010
    ..Results from these studies will help to identify new target for developing novel therapies to treat these life-threatening conditions. ..
  83. Prevention of Candidiasis in Critically III Patients
    SHELLEY MAGILL; Fiscal Year: 2007
    ....