chronic disease

Summary

Summary: Diseases which have one or more of the following characteristics: they are permanent, leave residual disability, are caused by nonreversible pathological alteration, require special training of the patient for rehabilitation, or may be expected to require a long period of supervision, observation, or care. (Dictionary of Health Services Management, 2d ed)

Top Publications

  1. ncbi A more accurate method to estimate glomerular filtration rate from serum creatinine: a new prediction equation. Modification of Diet in Renal Disease Study Group
    A S Levey
    New England Medical Center, Boston, MA 02111, USA
    Ann Intern Med 130:461-70. 1999
  2. ncbi Chronic kidney disease and the risks of death, cardiovascular events, and hospitalization
    Alan S Go
    Division of Research, Kaiser Permanente of Northern California, Oakland, CA 94612 2304, USA
    N Engl J Med 351:1296-305. 2004
  3. ncbi PedsQL 4.0: reliability and validity of the Pediatric Quality of Life Inventory version 4.0 generic core scales in healthy and patient populations
    J W Varni
    Center for Child Health Outcomes, Children s Hospital and Health Center, San Diego, California, USA
    Med Care 39:800-12. 2001
  4. doi Priority actions for the non-communicable disease crisis
    Robert Beaglehole
    University of Auckland, Auckland, New Zealand
    Lancet 377:1438-47. 2011
  5. ncbi Health promotion by social cognitive means
    Albert Bandura
    Department of Psychology, Stanford University, Stanford, California 94305 2130, USA
    Health Educ Behav 31:143-64. 2004
  6. doi Aging with multimorbidity: a systematic review of the literature
    Alessandra Marengoni
    Aging Research Center, NVS Department, Karolinska Institutet and Stockholm University, Sweden
    Ageing Res Rev 10:430-9. 2011
  7. ncbi Interpretation of changes in health-related quality of life: the remarkable universality of half a standard deviation
    Geoffrey R Norman
    Program for Educational Research and Development, McMaster University, Hamilton, ON, Canada
    Med Care 41:582-92. 2003
  8. ncbi The burden and costs of chronic diseases in low-income and middle-income countries
    Dele O Abegunde
    Department of Chronic Diseases and Health Promotion, World Health Organization, Geneva, Switzerland
    Lancet 370:1929-38. 2007
  9. ncbi National Kidney Foundation practice guidelines for chronic kidney disease: evaluation, classification, and stratification
    Andrew S Levey
    Tufts New England Medical Center and Tufts University School of Medicine, Boston, Massachusetts, USA
    Ann Intern Med 139:137-47. 2003
  10. ncbi ACC/AHA 2005 Guideline Update for the Diagnosis and Management of Chronic Heart Failure in the Adult: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Update the 2001 Guideli
    Sharon Ann Hunt
    Circulation 112:e154-235. 2005

Detail Information

Publications311 found, 100 shown here

  1. ncbi A more accurate method to estimate glomerular filtration rate from serum creatinine: a new prediction equation. Modification of Diet in Renal Disease Study Group
    A S Levey
    New England Medical Center, Boston, MA 02111, USA
    Ann Intern Med 130:461-70. 1999
    ..Serum creatinine concentration is widely used as an index of renal function, but this concentration is affected by factors other than glomerular filtration rate (GFR)...
  2. ncbi Chronic kidney disease and the risks of death, cardiovascular events, and hospitalization
    Alan S Go
    Division of Research, Kaiser Permanente of Northern California, Oakland, CA 94612 2304, USA
    N Engl J Med 351:1296-305. 2004
    ..End-stage renal disease substantially increases the risks of death, cardiovascular disease, and use of specialized health care, but the effects of less severe kidney dysfunction on these outcomes are less well defined...
  3. ncbi PedsQL 4.0: reliability and validity of the Pediatric Quality of Life Inventory version 4.0 generic core scales in healthy and patient populations
    J W Varni
    Center for Child Health Outcomes, Children s Hospital and Health Center, San Diego, California, USA
    Med Care 39:800-12. 2001
    ..The PedsQL 4.0 Generic Core Scales consist of 23 items applicable for healthy school and community populations, as well as pediatric populations with acute and chronic health conditions...
  4. doi Priority actions for the non-communicable disease crisis
    Robert Beaglehole
    University of Auckland, Auckland, New Zealand
    Lancet 377:1438-47. 2011
    ..If widely adopted, these interventions will achieve the global goal of reducing NCD death rates by 2% per year, averting tens of millions of premature deaths in this decade...
  5. ncbi Health promotion by social cognitive means
    Albert Bandura
    Department of Psychology, Stanford University, Stanford, California 94305 2130, USA
    Health Educ Behav 31:143-64. 2004
    ..Human health is a social matter, not just an individual one. A comprehensive approach to health promotion also requires changing the practices of social systems that have widespread effects on human health...
  6. doi Aging with multimorbidity: a systematic review of the literature
    Alessandra Marengoni
    Aging Research Center, NVS Department, Karolinska Institutet and Stockholm University, Sweden
    Ageing Res Rev 10:430-9. 2011
    ..New insights in this field can lead to the identification of preventive strategies and better treatment of multimorbid patients...
  7. ncbi Interpretation of changes in health-related quality of life: the remarkable universality of half a standard deviation
    Geoffrey R Norman
    Program for Educational Research and Development, McMaster University, Hamilton, ON, Canada
    Med Care 41:582-92. 2003
    ..A number of studies have computed the minimally important difference (MID) for health-related quality of life instruments...
  8. ncbi The burden and costs of chronic diseases in low-income and middle-income countries
    Dele O Abegunde
    Department of Chronic Diseases and Health Promotion, World Health Organization, Geneva, Switzerland
    Lancet 370:1929-38. 2007
    ..diseases, and diabetes-in 23 selected countries which account for around 80% of the total burden of chronic disease mortality in developing countries...
  9. ncbi National Kidney Foundation practice guidelines for chronic kidney disease: evaluation, classification, and stratification
    Andrew S Levey
    Tufts New England Medical Center and Tufts University School of Medicine, Boston, Massachusetts, USA
    Ann Intern Med 139:137-47. 2003
    ..Because of the high prevalence of early stages of chronic kidney disease in the general population (approximately 11% of adults), this information is particularly important for general internists and specialists...
  10. ncbi ACC/AHA 2005 Guideline Update for the Diagnosis and Management of Chronic Heart Failure in the Adult: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Update the 2001 Guideli
    Sharon Ann Hunt
    Circulation 112:e154-235. 2005
  11. ncbi Patient self-management of chronic disease in primary care
    Thomas Bodenheimer
    Department of Family and Community Medicine, University of California, San Francisco, USA
    JAMA 288:2469-75. 2002
    ..This reality introduces a new chronic disease paradigm: the patient-professional partnership, involving collaborative care and self-management education...
  12. ncbi Survey of chronic pain in Europe: prevalence, impact on daily life, and treatment
    Harald Breivik
    University of Oslo, Faculty of Medicine, Faculty Division Rikshospitalet, Department of Anaesthesiology, Rikshospitalet University Hospital, Norway
    Eur J Pain 10:287-333. 2006
    ..Forty percent had inadequate management of their pain. Interesting differences between countries were observed, possibly reflecting differences in cultural background and local traditions in managing chronic pain...
  13. ncbi National Institutes of Health consensus development project on criteria for clinical trials in chronic graft-versus-host disease: I. Diagnosis and staging working group report
    Alexandra H Filipovich
    Cincinnati Children s Hospital Medical Center, University of Cincinnati, Cincinnati, Ohio 45229, USA
    Biol Blood Marrow Transplant 11:945-56. 2005
    ..It is currently recommended that systemic therapy be considered for patients who meet criteria for chronic GVHD of moderate to severe global severity...
  14. ncbi Microbial translocation is a cause of systemic immune activation in chronic HIV infection
    Jason M Brenchley
    Human Immunology Section, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Med 12:1365-71. 2006
    ..These data establish a mechanism for chronic immune activation in the context of a compromised gastrointestinal mucosal surface and provide new directions for therapeutic interventions that modify the consequences of acute HIV infection...
  15. pmc The end of AIDS: HIV infection as a chronic disease
    Steven G Deeks
    Department of Medicine, University of California, San Francisco, CA, USA Electronic address
    Lancet 382:1525-33. 2013
    ..longer the primary threat, but a new set of HIV-associated complications have emerged, resulting in a novel chronic disease that for many will span several decades of life...
  16. ncbi Generalisability of The Health Improvement Network (THIN) database: demographics, chronic disease prevalence and mortality rates
    Betina T Blak
    Cegedim Strategic Data Medical Research Ltd, London, UK
    Inform Prim Care 19:251-5. 2011
    ..This report describes the representativeness of The Health Improvement Network (THIN), a UK primary care database, of the UK population...
  17. pmc The role of exercise and PGC1alpha in inflammation and chronic disease
    Christoph Handschin
    Institute of Physiology and Zurich Center for Integrative Human Physiology ZIHP, University of Zurich, CH 8057 Zurich, Switzerland
    Nature 454:463-9. 2008
    ..We propose that this protein controls muscle plasticity, suppresses a broad inflammatory response and mediates the beneficial effects of exercise...
  18. pmc Chronic cerebrospinal venous insufficiency in patients with multiple sclerosis
    P Zamboni
    Vascular Diseases Center, University of Ferrara, Ferrara, Italy
    J Neurol Neurosurg Psychiatry 80:392-9. 2009
    ..The extracranial venous outflow routes in clinically defined multiple sclerosis (CDMS) have not previously been investigated...
  19. ncbi Prevalence, expenditures, and complications of multiple chronic conditions in the elderly
    Jennifer L Wolff
    Department of Health Policy and Management, The Johns Hopkins University Bloomberg School of Public Health, 624 N Broadway, Room 304, Baltimore, MD 21205, USA
    Arch Intern Med 162:2269-76. 2002
    ..The prevalence, health care expenditures, and hospitalization experiences are important considerations among elderly populations with multiple chronic conditions...
  20. ncbi New appendix criteria open for a broader concept of chronic migraine
    J Olesen
    Department of Neurology, University of Copenhagen, Glostrup Hospital, Demark
    Cephalalgia 26:742-6. 2006
    ..If these new criteria for CM and MOH prove useful in future testing, the plan is to include them in a future revised version of ICHD-2...
  21. doi Emergence of chronic non-communicable diseases in China
    Gonghuan Yang
    Chinese Centre for Disease Control and Prevention, Beijing, China Institute of Basic Medical Sciences of Chinese Academy of Medical Sciences and School of Basic Medicine of Peking Union Medical College, Beijing, China
    Lancet 372:1697-705. 2008
    ..Emergence of chronic diseases presents special challenges for China's ongoing reform of health care, given the large numbers who require curative treatment and the narrow window of opportunity for timely prevention of disease...
  22. doi Tackling of unhealthy diets, physical inactivity, and obesity: health effects and cost-effectiveness
    Michele Cecchini
    Health Division, Organisation for Economic Co operation and Development OECD, Paris, France
    Lancet 376:1775-84. 2010
    ..A package of measures for the prevention of chronic diseases would deliver substantial health gains, with a very favourable cost-effectiveness profile...
  23. ncbi Improving primary care for patients with chronic illness
    Thomas Bodenheimer
    Family and Community Medicine, University of California, San Francisco, USA
    JAMA 288:1775-9. 2002
    ..Case studies are provided describing how components of the chronic care model have been implemented in the primary care practices of 4 health care organizations...
  24. ncbi Core outcome measures for chronic pain clinical trials: IMMPACT recommendations
    Robert H Dworkin
    Department of Anesthesiology, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Pain 113:9-19. 2005
  25. doi The burden of non-communicable diseases in South Africa
    Bongani M Mayosi
    Department of Medicine, Groote Schuur Hospital and University of Cape Town, Cape Town, South Africa
    Lancet 374:934-47. 2009
    ....
  26. pmc The effectiveness of Web-based vs. non-Web-based interventions: a meta-analysis of behavioral change outcomes
    Dean J Wantland
    Department of Community Health Systems, University of California, San Francisco, N531M, School of Nursing, San Francisco CA 94143, USA
    J Med Internet Res 6:e40. 2004
    ..The use and effectiveness of Web-based interventions to encourage an individual's change in behavior compared to non-Web-based interventions have not been substantially reviewed...
  27. ncbi The Health Education Impact Questionnaire (heiQ): an outcomes and evaluation measure for patient education and self-management interventions for people with chronic conditions
    Richard H Osborne
    Centre for Rheumatic Diseases, Department of Medicine, The University of Melbourne, Royal Melbourne Hospital, Parkville, Melbourne, Victoria 3050, Australia
    Patient Educ Couns 66:192-201. 2007
    ..The aim was to develop a user-friendly, relevant, and psychometrically sound instrument for the comprehensive evaluation of patient education programs, which can be applied across a broad range of chronic conditions...
  28. ncbi Is China facing an obesity epidemic and the consequences? The trends in obesity and chronic disease in China
    Y Wang
    Center for Human Nutrition, Department of International Health, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA
    Int J Obes (Lond) 31:177-88. 2007
    Over the past two decades, China has enjoyed impressive economic development, and her citizens have experienced many remarked changes in their lifestyle. These changes are often associated with an increase in obesity and chronic disease.
  29. pmc Epidemiology and impact of multimorbidity in primary care: a retrospective cohort study
    Chris Salisbury
    Department of Community Medicine, University of Bristol, UK
    Br J Gen Pract 61:e12-21. 2011
    ..In developed countries, primary health care increasingly involves the care of patients with multiple chronic conditions, referred to as multimorbidity...
  30. ncbi Prevalence of chronic kidney disease and decreased kidney function in the adult US population: Third National Health and Nutrition Examination Survey
    Josef Coresh
    Department of Epidemiology, Bloomberg School of Public Health, The Johns Hopkins University, Baltimore, MD, USA
    Am J Kidney Dis 41:1-12. 2003
    ....
  31. ncbi Glycemic index, glycemic load, and chronic disease risk--a meta-analysis of observational studies
    Alan W Barclay
    Human Nutrition Unit, University of Sydney, Sydney, Australia
    Am J Clin Nutr 87:627-37. 2008
    ..Inconsistent findings from observational studies have prolonged the controversy over the effects of dietary glycemic index (GI) and glycemic load (GL) on the risk of certain chronic diseases...
  32. ncbi Development and validation of the Patient Assessment of Chronic Illness Care (PACIC)
    Russell E Glasgow
    Kaiser Permanente Colorado, Denver, Colorado, USA
    Med Care 43:436-44. 2005
    ....
  33. ncbi Fear-avoidance and its consequences in chronic musculoskeletal pain: a state of the art
    J W Vlaeyen
    Department of Medical, Clinical and Experimental Psychology, Maastricht University, P O Box 616, 6200 MD, Maastricht, The Netherlands
    Pain 85:317-32. 2000
    ....
  34. ncbi Chronic back pain is associated with decreased prefrontal and thalamic gray matter density
    A Vania Apkarian
    Department of Physiology and Institute of Neuroscience, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
    J Neurosci 24:10410-5. 2004
    ..Our results imply that CBP is accompanied by brain atrophy and suggest that the pathophysiology of chronic pain includes thalamocortical processes...
  35. ncbi The global burden of chronic diseases: overcoming impediments to prevention and control
    Derek Yach
    World Health Organization, Geneva, Switzerland
    JAMA 291:2616-22. 2004
    ..The influence of global economic factors on chronic disease risks impedes progress, as does the orientation of health systems toward acute care...
  36. ncbi A life course approach to chronic disease epidemiology: conceptual models, empirical challenges and interdisciplinary perspectives
    Yoav Ben-Shlomo
    Int J Epidemiol 31:285-93. 2002
  37. pmc Direct interaction between sensor kinase proteins mediates acute and chronic disease phenotypes in a bacterial pathogen
    Andrew L Goodman
    Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA
    Genes Dev 23:249-59. 2009
    ..These results suggest that multiple two-component systems found in a single bacterium can form multisensor signaling networks while maintaining specific phosphorelay pathways that remain insulated from detrimental cross-talk...
  38. pmc Prevalence of chronic diseases and multimorbidity among the elderly population in Sweden
    Alessandra Marengoni
    Aging Research Center, Karolinska Institutet, Stockholm, Sweden
    Am J Public Health 98:1198-200. 2008
    ..Multimorbidity is the most common clinical picture of the elderly and may be increased by unhealthy behaviors linked to education...
  39. ncbi Patients' beliefs about prescribed medicines and their role in adherence to treatment in chronic physical illness
    R Horne
    Centre for Health Care Reserach, University of Brighton, UK
    J Psychosom Res 47:555-67. 1999
    ....
  40. ncbi Chronic kidney disease: the global challenge
    A Meguid El Nahas
    Sheffield Kidney Institute, Sheffield Teaching Hospital NHS Foundation Trust, Northern General Hospital Campus, University of Sheffield, Sheffield S5 7AU, UK
    Lancet 365:331-40. 2005
    ..Consideration is given to health economics. A global and concerted approach to CKD must be adopted in both more and less developed countries to avoid a major catastrophe...
  41. ncbi The association of depression and anxiety with medical symptom burden in patients with chronic medical illness
    Wayne Katon
    Department of Psychiatry, University of Washington School of Medicine, Seattle, WA 98195 6560, USA
    Gen Hosp Psychiatry 29:147-55. 2007
    ..Primary care patients with anxiety and depression often describe multiple physical symptoms, but no systematic review has studied the effect of anxiety and depressive comorbidity in patients with chronic medical illnesses...
  42. ncbi Self-management education: history, definition, outcomes, and mechanisms
    Kate R Lorig
    Ann Behav Med 26:1-7. 2003
    ..In conclusion the article discusses problems and solutions for integrating self-management education into the mainstream health care systems...
  43. ncbi Molecular signature of CD8+ T cell exhaustion during chronic viral infection
    E John Wherry
    Emory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine, 1510 Clifton Road Room G211, Atlanta, GA 30322, USA
    Immunity 27:670-84. 2007
    ..Thus, functional exhaustion is probably due to both active suppression and passive defects in signaling and metabolism. These results provide a framework for designing rational immunotherapies during chronic infections...
  44. pmc Chapter 4. European guidelines for the management of chronic nonspecific low back pain
    O Airaksinen
    Eur Spine J 15:S192-300. 2006
  45. ncbi Kidney disease as a risk factor for development of cardiovascular disease: a statement from the American Heart Association Councils on Kidney in Cardiovascular Disease, High Blood Pressure Research, Clinical Cardiology, and Epidemiology and Prevention
    Mark J Sarnak
    Hypertension 42:1050-65. 2003
  46. doi Ferric carboxymaltose in patients with heart failure and iron deficiency
    Stefan D Anker
    Department of Cardiology, Campus Virchow Klinikum, Charite Universitatsmedizin, Berlin
    N Engl J Med 361:2436-48. 2009
    ....
  47. ncbi The pain self-efficacy questionnaire: Taking pain into account
    Michael K Nicholas
    Pain Management and Research Centre, University of Sydney at Royal North Shore Hospital, St Leonards, Sydney, NSW 2065, Australia
    Eur J Pain 11:153-63. 2007
    ....
  48. ncbi Biofilms in chronic wounds
    Garth A James
    Center for Biofilm Engineering, Montana State University Bozeman, Bozeman, Montana 59717, USA
    Wound Repair Regen 16:37-44. 2008
    ..Bacterial biofilm prevalence in specimens from chronic wounds relative to acute wounds observed in this study provides evidence that biofilms may be abundant in chronic wounds...
  49. ncbi Systematic review: strategies for using exercise therapy to improve outcomes in chronic low back pain
    Jill A Hayden
    Institute for Work and Health and University of Toronto, Toronto, Ontario, Canada
    Ann Intern Med 142:776-85. 2005
    ..Exercise therapy encompasses a heterogeneous group of interventions. There continues to be uncertainty about the most effective exercise approach in chronic low back pain...
  50. doi IL-21R on T cells is critical for sustained functionality and control of chronic viral infection
    Anja Fröhlich
    Molecular Biomedicine, Institute of Integrative Biology, ETH Zurich, Switzerland
    Science 324:1576-80. 2009
    ..These data suggest that IL-21R signaling is required for the maintenance of polyfunctional T cells during chronic viral infections and have implications for understanding the immune response to other persisting antigens, such as tumors...
  51. ncbi Causes and consequences of comorbidity: a review
    R Gijsen
    National Institute of Public Health and the Environment, P O Box 1, 3720 BA, Bilthoven, The Netherlands
    J Clin Epidemiol 54:661-74. 2001
    ..Health care workers need to take comorbid diseases into account in monitoring and treating patients. Future studies on consequences of comorbidity should investigate specific disease combinations...
  52. ncbi Improving chronic illness care: translating evidence into action
    E H Wagner
    W.A. MacColl Institute for Healthcare Innovation at the Center for Health Studies, Group Health Cooperative of Puget Sound, Seattle, USA
    Health Aff (Millwood) 20:64-78. 2001
    ..In this paper we describe the CCM, its use in intensive quality improvement activities with more than 100 health care organizations, and insights gained in the process...
  53. ncbi Clinical practice guidelines and quality of care for older patients with multiple comorbid diseases: implications for pay for performance
    Cynthia M Boyd
    Division of Geriatric Medicine, School of Medicine, Johns Hopkins University, Baltimore, MD, USA
    JAMA 294:716-24. 2005
    ..Clinical practice guidelines (CPGs) have been developed to improve the quality of health care for many chronic conditions. Pay-for-performance initiatives assess physician adherence to interventions that may reflect CPG recommendations...
  54. pmc Viral persistence alters CD8 T-cell immunodominance and tissue distribution and results in distinct stages of functional impairment
    E John Wherry
    Emory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Virol 77:4911-27. 2003
    ..These results have implications for the study of human chronic infections, where similar T-cell deletion and functional dysregulation has been observed...
  55. pmc Food insecurity is associated with chronic disease among low-income NHANES participants
    Hilary K Seligman
    Department of Medicine, San Francisco General Hospital, University of California, San Francisco, CA 94143, USA
    J Nutr 140:304-10. 2010
    ..We therefore examined the association between food insecurity and clinical evidence of diet-sensitive chronic disease, including hypertension, hyperlipidemia, and diabetes...
  56. ncbi German Acupuncture Trials (GERAC) for chronic low back pain: randomized, multicenter, blinded, parallel-group trial with 3 groups
    Michael Haake
    Orthopaedic Department, University of Regensburg, Bad Abbach, Germany
    Arch Intern Med 167:1892-8. 2007
    ..To our knowledge, verum acupuncture has never been directly compared with sham acupuncture and guideline-based conventional therapy in patients with chronic low back pain...
  57. pmc A vital role for interleukin-21 in the control of a chronic viral infection
    John S Yi
    Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL 35294 2170, USA
    Science 324:1572-6. 2009
    ..Thus, IL-21 serves as a critical helper factor that shapes the functional quality of antiviral CD8+ T cells and is required for viral control...
  58. ncbi Acupuncture in patients with chronic low back pain: a randomized controlled trial
    Benno Brinkhaus
    Institute of Social Medicine, Epidemiology, and Health Economics, Charite, University Medical Center, Berlin, Germany
    Arch Intern Med 166:450-7. 2006
    ..Acupuncture is widely used by patients with low back pain, although its effectiveness is unclear. We investigated the efficacy of acupuncture compared with minimal acupuncture and with no acupuncture in patients with chronic low back pain...
  59. ncbi Depression and pain comorbidity: a literature review
    Matthew J Bair
    Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA
    Arch Intern Med 163:2433-45. 2003
    ..A model that incorporates assessment and treatment of depression and pain simultaneously is necessary for improved outcomes...
  60. pmc Defining comorbidity: implications for understanding health and health services
    Jose M Valderas
    National Institute for Health Research School for Primary Care Research, The University of Manchester, Manchester, United Kingdom
    Ann Fam Med 7:357-63. 2009
    ..We conclude that the more precise use of constructs, as proposed in this article, would lead to improved research into the phenomenon of ill health in clinical care, epidemiology, and health services...
  61. doi Fifty communities putting prevention to work: accelerating chronic disease prevention through policy, systems and environmental change
    Rebecca Bunnell
    Division of Community Health, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, 4770 Buford Hwy, MS K45, Atlanta, GA 30341, USA
    J Community Health 37:1081-90. 2012
    ..Findings on the progress and potential reach of this major initiative may help inform future chronic disease prevention efforts.
  62. pmc Anti-inflammatory therapy in chronic disease: challenges and opportunities
    Ira Tabas
    Department of Medicine, Columbia University, New York, NY 10032, USA
    Science 339:166-72. 2013
    ..However, new advances in understanding inflammatory signaling and its links to resolution pathways, together with new drug development, offer promise in this area of translational biomedical research...
  63. ncbi Chronic kidney disease as a global public health problem: approaches and initiatives - a position statement from Kidney Disease Improving Global Outcomes
    A S Levey
    Tufts New England Medical Center, Boston, Massachusetts, USA
    Kidney Int 72:247-59. 2007
    ..KDIGO will work in collaboration with international and national public health organizations to facilitate implementation of these recommendations...
  64. ncbi Diet quality and major chronic disease risk in men and women: moving toward improved dietary guidance
    Marjorie L McCullough
    American Cancer Society, Atlanta, GA 30329, USA
    Am J Clin Nutr 76:1261-71. 2002
    ..with the US Department of Agriculture Healthy Eating Index (HEI), was associated with only a small reduction in major chronic disease risk. Research suggests that greater reductions in risk are possible with more specific guidance.
  65. pmc Telemonitoring or structured telephone support programmes for patients with chronic heart failure: systematic review and meta-analysis
    Robyn A Clark
    Division of Health Sciences, University of South Australia, Adelaide, Australia
    BMJ 334:942. 2007
    ..To determine whether remote monitoring (structured telephone support or telemonitoring) without regular clinic or home visits improves outcomes for patients with chronic heart failure...
  66. ncbi Adherence to medication
    Lars Osterberg
    General Medicine Division, Veterans Affairs Palo Alto Health Care System, Palo Alto, California 94304, USA
    N Engl J Med 353:487-97. 2005
  67. ncbi Development of the 25-item National Eye Institute Visual Function Questionnaire
    C M Mangione
    Division of General Internal Medicine and Health Services Research, Department of Medicine, UCLA, 911 Broxton Plaza, Box 951736, Los Angeles, CA 90095-1736, USA
    Arch Ophthalmol 119:1050-8. 2001
    ....
  68. doi A prospective open-label study of endovascular treatment of chronic cerebrospinal venous insufficiency
    Paolo Zamboni
    Vascular Diseases Center, University of Ferrara, Ferrara, Italy
    J Vasc Surg 50:1348-58.e1-3. 2009
    ..CCSVI is strongly associated with multiple sclerosis (MS). This study evaluated the safety of CCSVI endovascular treatment and its influence on the clinical outcome of the associated MS...
  69. ncbi Designing randomized, controlled trials aimed at preventing or delaying functional decline and disability in frail, older persons: a consensus report
    Luigi Ferrucci
    Clinical Research Branch, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, USA
    J Am Geriatr Soc 52:625-34. 2004
    ....
  70. pmc Multimorbidity patterns in the elderly: a new approach of disease clustering identifies complex interrelations between chronic conditions
    Ingmar Schafer
    Department of Primary Medical Care, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    PLoS ONE 5:e15941. 2010
    ..The aim of this study was to increase the knowledge of specific processes of multimorbidity in an unselected elderly population by identifying patterns of statistically significantly associated comorbidity...
  71. ncbi Interleukin-10-deficient mice develop chronic enterocolitis
    R Kuhn
    Institute for Genetics, University of Cologne, Federal Republic of Germany
    Cell 75:263-74. 1993
    ..These results indicate that the bowel inflammation in the mutants originates from uncontrolled immune responses stimulated by enteric antigens and that IL-10 is an essential immunoregulator in the intestinal tract...
  72. doi EPOS 2012: European position paper on rhinosinusitis and nasal polyps 2012. A summary for otorhinolaryngologists
    Wytske J Fokkens
    Department of Otorhinolaryngology, Academic Medical Center, Amsterdam, The Netherlands
    Rhinology 50:1-12. 2012
    ..This executive summary for otorhinolaryngologists focuses on the most important changes and issues for otorhinolaryngologists. The full document can be downloaded for free on the website of this journal: http://www.rhinologyjournal.com...
  73. pmc Quantitative analysis of cellular inflammation after traumatic spinal cord injury: evidence for a multiphasic inflammatory response in the acute to chronic environment
    Kevin D Beck
    Anatomy and Neurobiology, University of California, Irvine, CA 92697 4292, USA
    Brain 133:433-47. 2010
    ....
  74. pmc Which chronic diseases and disease combinations are specific to multimorbidity in the elderly? Results of a claims data based cross-sectional study in Germany
    Hendrik van den Bussche
    Department of Primary Medical Care, Center of Psychosocial Medicine, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    BMC Public Health 11:101. 2011
    ..This is the first comprehensive study addressing multimorbidity on the basis of German claims data. The main research question was to find out which chronic diseases and disease combinations are specific to multimorbidity in the elderly...
  75. ncbi The natural history of chronic allograft nephropathy
    Brian J Nankivell
    Department of Renal Medicine, University of Sydney, Westmead Hospital, Sydney, NSW, Australia
    N Engl J Med 349:2326-33. 2003
    ..With improved immunosuppression and early allograft survival, chronic allograft nephropathy has become the dominant cause of kidney-transplant failure...
  76. ncbi Clinical importance of changes in chronic pain intensity measured on an 11-point numerical pain rating scale
    J T Farrar
    Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Blockley Hall, Room 816, 423 Guardian Drive, Philadelphia, PA 19104, USA
    Pain 94:149-58. 2001
    ..Use of a standard outcome across chronic pain studies would greatly enhance the comparability, validity, and clinical applicability of these studies...
  77. ncbi Effect of a self-management program on patients with chronic disease
    K R Lorig
    Stanford University School of Medicine, Calif, USA
    Eff Clin Pract 4:256-62. 2001
    For patients with chronic disease, there is growing interest in "self-management" programs that emphasize the patients' central role in managing their illness...
  78. ncbi Use of the Patient Assessment of Chronic Illness Care (PACIC) with diabetic patients: relationship to patient characteristics, receipt of care, and self-management
    Russell E Glasgow
    Kaiser Permanente Colorado, Denver, CO, USA
    Diabetes Care 28:2655-61. 2005
    ..There is a dearth of information on the extent to which diabetic patients receive care congruent with the chronic care model (CCM) and evidence-based behavioral counseling. This study evaluates a new instrument to fill this gap...
  79. ncbi Health-related quality of life associated with chronic conditions in eight countries: results from the International Quality of Life Assessment (IQOLA) Project
    Jordi Alonso
    Health Services Research Unit, Institut Municipal d Investigacio Medica IMIM IMAS, Barcelona, Spain
    Qual Life Res 13:283-98. 2004
    ..Few studies and no international comparisons have examined the impact of multiple chronic conditions on populations using a comprehensive health-related quality of life (HRQL) questionnaire...
  80. doi A placebo-controlled trial of prucalopride for severe chronic constipation
    Michael Camilleri
    College of Medicine, Mayo Clinic, Rochester, MN 55905, USA
    N Engl J Med 358:2344-54. 2008
    ..In this 12-week trial, we aimed to determine the efficacy of prucalopride, a selective, high-affinity 5-hydroxytryptamine4 receptor agonist, in patients with severe chronic constipation...
  81. ncbi Progression of chronic kidney disease: the role of blood pressure control, proteinuria, and angiotensin-converting enzyme inhibition: a patient-level meta-analysis
    Tazeen H Jafar
    Tufts New England Medical Center, Boston, Massachusetts 02111, USA
    Ann Intern Med 139:244-52. 2003
    ..Angiotensin-converting enzyme (ACE) inhibitors reduce blood pressure and urine protein excretion and slow the progression of chronic kidney disease...
  82. pmc Development of the Patient Activation Measure (PAM): conceptualizing and measuring activation in patients and consumers
    Judith H Hibbard
    Department of Planning, Public Policy, and Management, University of Oregon, Eugene 97403 1209, USA
    Health Serv Res 39:1005-26. 2004
    ..Controlling costs and achieving health care quality improvements require the participation of activated and informed consumers and patients...
  83. ncbi Improving primary care for patients with chronic illness: the chronic care model, Part 2
    Thomas Bodenheimer
    Family and Community Medicine, University of California, San Francisco, USA
    JAMA 288:1909-14. 2002
    ..Even though the chronic care model has the potential to improve care and reduce costs, several obstacles hinder its widespread adoption...
  84. pmc Twenty years of telemedicine in chronic disease management--an evidence synthesis
    Richard Wootton
    Norwegian Centre for Integrated Care and Telemedicine, Tromsø, Norway
    J Telemed Telecare 18:211-20. 2012
    ..Third, most studies have been relatively short-term (median duration 6 months). It seems unlikely that in a chronic disease, any intervention can have much effect unless applied for a long period...
  85. ncbi Kidney disease as a risk factor for development of cardiovascular disease: a statement from the American Heart Association Councils on Kidney in Cardiovascular Disease, High Blood Pressure Research, Clinical Cardiology, and Epidemiology and Prevention
    Mark J Sarnak
    Circulation 108:2154-69. 2003
  86. pmc Helminth secretions induce de novo T cell Foxp3 expression and regulatory function through the TGF-β pathway
    John R Grainger
    Institute of Immunology and Infection Research, University of Edinburgh, Edinburgh EH9 3JT, Scotland, UK
    J Exp Med 207:2331-41. 2010
    ..We have therefore identified a novel pathway through which helminth parasites may stimulate T reg cells, which is likely to be a key part of the parasite's immunological relationship with the host...
  87. ncbi The impact of patient expectations on outcomes in four randomized controlled trials of acupuncture in patients with chronic pain
    Klaus Linde
    Centre for Complementary Medicine Research, Department of Internal Medicine II, Technische Universitat Munchen, Kaiserstr 9, 80801 Munich, Germany
    Pain 128:264-71. 2007
    ..03 (1.26-3.26) and 2.35 (1.68-3.30), respectively. Results from the 6-month follow-up were similar. In conclusion, in our trials a significant association was shown between better improvement and higher outcome expectations...
  88. ncbi Acute colitis induced by dextran sulfate sodium progresses to chronicity in C57BL/6 but not in BALB/c mice: correlation between symptoms and inflammation
    Silvia Melgar
    AstraZeneca R and D Molndal, Dept of Integrative Pharmacology, GI Biology, SE 431 83 Molndal, Sweden
    Am J Physiol Gastrointest Liver Physiol 288:G1328-38. 2005
    ..We believe that the present protocol to induce chronic colitis in C57BL/6 mice offers a robust model for validating future therapies for treatment of inflammatory bowel disease...
  89. doi Evidence on the Chronic Care Model in the new millennium
    Katie Coleman
    MacColl Institute for Healthcare Innovation, Group Health Center for Health Studies, Seattle, Washington, USA
    Health Aff (Millwood) 28:75-85. 2009
    ..Although work remains to be done in areas such as cost-effectiveness, these studies suggest that redesigning care using the CCM leads to improved patient care and better health outcomes...
  90. ncbi Pain-related fear is more disabling than pain itself: evidence on the role of pain-related fear in chronic back pain disability
    G Crombez
    Vakgroep Gedragstherapie en Psychologische Begeleiding, Universiteit te Gent, Belgium
    Pain 80:329-39. 1999
    ..Implications for chronic back pain assessment, prevention and treatment are discussed...
  91. pmc Barriers to evidence-based decision making in public health: a national survey of chronic disease practitioners
    Julie A Jacobs
    Prevention Research Center in St Louis, Saint Louis University School of Public Health, St Louis, MO, USA
    Public Health Rep 125:736-42. 2010
    Existing knowledge of evidence-based chronic disease prevention is not systematically disseminated or applied...
  92. ncbi The disease burden associated with overweight and obesity
    A Must
    Department of Family Medicine and Community Health, Tufts University School of Medicine, Boston, MA 02111, USA
    JAMA 282:1523-9. 1999
    ..Overweight and obesity are increasing dramatically in the United States and most likely contribute substantially to the burden of chronic health conditions...
  93. doi The prevalence of multimorbidity in primary care and its effect on health care utilization and cost
    Liam G Glynn
    Department of General Practice, National University of Ireland, Galway, Ireland
    Fam Pract 28:516-23. 2011
    ..Multimorbidity is common among the heterogeneous primary care population, but little data exist on its association with health care utilization or cost...
  94. ncbi Chronic disease prevention: health effects and financial costs of strategies to reduce salt intake and control tobacco use
    Perviz Asaria
    Kings Fund, London, UK
    Lancet 370:2044-53. 2007
    ..in the distribution of risk factors associated with salt intake and tobacco use, and to model the effects on chronic disease mortality for 23 countries that account for 80% of chronic disease burden in the developing world...
  95. ncbi Self-management approaches for people with chronic conditions: a review
    Julie Barlow
    Interdisciplinary Research Centre in Health, Psychosocial Research Centre, School of Health and Social Sciences, Coventry University, Priory St, Coventry CV1 5FB, England, UK
    Patient Educ Couns 48:177-87. 2002
    ..g. format, content, tutor, setting), outcomes and effectiveness. The last of these focused on reports of randomised controlled studies...
  96. pmc Coregulation of CD8+ T cell exhaustion by multiple inhibitory receptors during chronic viral infection
    Shawn D Blackburn
    Immunology Program and Wistar Vaccine Center, Wistar Institute, Philadelphia, Pennsylvania 19104, USA
    Nat Immunol 10:29-37. 2009
    ..Thus, CD8+ T cell responses during chronic viral infections are regulated by complex patterns of coexpressed inhibitory receptors...
  97. pmc Memory CD8 T-cell differentiation during viral infection
    E John Wherry
    Emory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine, G211 Rollins Research Building, 1510 Clifton Rd, Atlanta, GA 30322, USA
    J Virol 78:5535-45. 2004
  98. ncbi Treatment-seeking behaviour, cost burdens and coping strategies among rural and urban households in Coastal Kenya: an equity analysis
    Jane Chuma
    Kenya Medical Research Institute, Kilifi, Kenya
    Trop Med Int Health 12:673-86. 2007
    ....
  99. doi Prevention and management of chronic disease: a litmus test for health-systems strengthening in low-income and middle-income countries
    Badara Samb
    World Health Organization, Geneva, Switzerland
    Lancet 376:1785-97. 2010
    ..Evidence is emerging that chronic disease interventions could contribute to strengthening the capacity of health systems to deliver a comprehensive ..
  100. ncbi painDETECT: a new screening questionnaire to identify neuropathic components in patients with back pain
    Rainer Freynhagen
    Klinik fur Anasthesiologie, Universitatsklinikum Dusseldorf, Dusseldorf, Germany
    Curr Med Res Opin 22:1911-20. 2006
    ....
  101. pmc Shift work and chronic disease: the epidemiological evidence
    X S Wang
    Cancer Epidemiology Unit, University of Oxford, Oxford, UK
    Occup Med (Lond) 61:78-89. 2011
    ..Recent reviews of evidence relating to these hypotheses have focussed on specific diseases or potential mechanisms, but no general summary of the current data on shift work and chronic disease has been published.

Research Grants79

  1. Optimized Growth Media to Detect Intracellular Bacteria Implicated in Chronic Dis
    PATRICIA MASCARELLI; Fiscal Year: 2011
    DESCRIPTION (provided by applicant): The CDC reports that over 40 million Americans suffer from chronic disease, the majority of whom report multiple diagnoses of chronic disorders...
  2. Reactive (AA)Amyloidosis
    Merrill D Benson; Fiscal Year: 2013
    ..This is a group of chronic disease patients that develop amyloidosis...
  3. Mechanisms of hepcidin effects in the anemia of chronic disease
    Robert T Means; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The anemia of chronic disease (ACD) is one of the most common clinical syndromes encountered in the practice of medicine...
  4. Maternal obesity depresses essential fatty acid transport in the placenta
    PERRIE F O'TIERNEY-GINN; Fiscal Year: 2012
    ..In keeping with this view, the placenta is an important element in the origins of adult chronic disease. The candidate has a strong scientific background in molecular biology, immunohistochemistry, primary cell ..
  5. A unique approach to identify markers for congenital syphilis and neurosyphilis
    Nikhat Parveen; Fiscal Year: 2010
    ..phases of disease in their hosts, including disseminated infection of various tissues followed by latent and chronic disease. Development of genetic tools for B...
  6. Maternal obesity depresses essential fatty acid transport in the placenta
    PERRIE F O'TIERNEY-GINN; Fiscal Year: 2013
    ..In keeping with this view, the placenta is an important element in the origins of adult chronic disease. The candidate has a strong scientific background in molecular biology, immunohistochemistry, primary cell ..
  7. Development of Vaccines against Clostridium difficile Infection
    SAUL R TZIPORI; Fiscal Year: 2013
    ..to elicit strong systemic and mucosal immunity to prevent CDI, reduce the severity, or eliminate an ongoing chronic disease. We propose to exploit the recently expressed atoxic C...
  8. N-methanocarbathymidine (N-MCT) for the Treatment of Herpes and Pox Virus Infecti
    Aquilur Rahman; Fiscal Year: 2013
    ..Herpes Simplex Virus (HSV) infection is a chronic disease that affects over 1 billion people worldwide, with distinct disease symptoms for each variant...
  9. The mechanisms by which alcohol and HIV render the lung susceptible to injury
    DAVID MARSHALL GUIDOT; Fiscal Year: 2013
    ..anti-retroviral regimens, the infection is at present incurable and infected individuals must battle a chronic disease that increases their risk of lung disease, heart disease, kidney failure and malignancies...
  10. Effects of Gastric Bypass Surgery on Calcium Metabolism and the Skeleton
    ANNE LOUISE SCHAFER; Fiscal Year: 2013
    ..Obesity is a chronic disease of staggering proportions...
  11. SARS-CoV Pathogenic Mechanisms in Senescent Mice
    Ralph S Baric; Fiscal Year: 2012
    ..study the pathogenesis of lethal and nonlethal SARS-CoV infection in young and senescent mice, determining if chronic disease manifestations of pulmonary fibrosis occur in survivors...
  12. Secondary Muscle Pathology &Metabolic Dysregulation in Adult with Cerebral Palsy
    Mark Peterson; Fiscal Year: 2013
    ..dietary interventions for children and adults with CP;and (3) To bolster public health awareness regarding chronic disease risks for specific sub-populations with disabilities...
  13. Fate of Lung Stem Cells During Pulmonary Disease
    Susan M Majka; Fiscal Year: 2012
    ..these strategies because of the diverse cell types and functions as well as a lack of understanding of how chronic disease processes affect stem cell differentiation...
  14. Health Care Disparities in the Pacific Islands Pacific Regional Medical Conferenc
    SAIED SAFABAKHSH; Fiscal Year: 2011
    ..on Tobacco Characteristics Update in Prenatal Diagnosis and Genetics Health on Guam, An epidemiology of chronic disease in Guam Health Disparities in Diabetes Current Opinions in Medical Ethics Chronic Kidney Disease for Primary ..
  15. Optimizing Chronic Disease Prevention and Management in Advanced Dementia
    Jennifer Tjia; Fiscal Year: 2010
    ..In this application, "Optimizing Chronic Disease Prevention and Management in Advanced Dementia", we propose to study the effectiveness of medication ..
  16. Role of natural indoles in experimental autoimmune encephalomyelitis
    Mitzi Nagarkatti; Fiscal Year: 2013
    ..It is a chronic disease characterized by inflammation in the central nervous system that results in neuron demyelination leading to ..
  17. Proteomic signatures of an early life asthma-protective exposure
    Serrine S Lau; Fiscal Year: 2010
    ..10-15% of the population in many western nations, including the United States, and it is the most common chronic disease in childhood...
  18. Genome-wide DNA Methylation Profiles Associated with Abnormal Intrauterine Growth
    Cristina Montagna; Fiscal Year: 2013
    ..The commonality of susceptibility to chronic disease and involvement of multiple organ systems is analogous to the normal decline of resistance to disease that ..
  19. Leptin function &resistance in midbrain VTA &SN in reward eating &obesity
    YI NONE ZHANG; Fiscal Year: 2013
    ..Diet-induced obesity (DIO) is the most common type of obesity and a major health-threatening chronic disease. Over-consumption of energy-dense, palatable food beyond basic caloric need promotes DIO...
  20. Excessive Copper Levels Disrupt Hepatic Nuclear Receptor Function
    Clavia Ruth Wooton-Kee; Fiscal Year: 2011
    ..measure the DNA-binding activity of nuclear receptors in a mouse animal model for Wilson's disease, a chronic disease that is characterized by excessive hepatic copper accumulation and severe liver dysfunction that results in ..
  21. Over-Expression of microRNA-126 in Macrophages for Treatment of Atherosclerosis
    Suzette Laing; Fiscal Year: 2013
    ..The continued monocyte recruitment and cholesterol accumulation in the vessel wall facilitates chronic disease progression...
  22. Control of alphavirous replacation in the nervous system
    Diane E Griffin; Fiscal Year: 2013
    ..is a particularly important global cause of morbidity and mortality because neuronal damage can lead to chronic disease and long-term disability, as well as acute fatal disease...
  23. Maternal-fetal vitamin D status and child adiposity, insulin resistance and BP
    Susanna Y Huh; Fiscal Year: 2010
    ..Further, maternal vitamin D status during pregnancy is associated with chronic disease in offspring, and the prenatal period has been implicated as a critical window for obesity development...
  24. Early Disease Biomarkers of PCB-exposed Human Population
    Sisir K Dutta; Fiscal Year: 2010
    ..reside with its ability to use non-invasive gene expression tools to study the early pathogenesis of the disease and to help the nation develop early intervention for multiple chronic disease that continue to burden our health system.
  25. Contribution of the Streptococcus mutans cid and lrg Murein Hydrolase Regulator H
    KELLY CHRISTINE RICE; Fiscal Year: 2010
    Streptococcus mutans is the primary causative agent of dental caries, which remains the most common chronic disease among children and is untreated in up to 30% of adults over 35 yrs-old...
  26. Race-based social stress and health trajectories from adolescence to adulthood
    Jacquelynne S Eccles; Fiscal Year: 2010
    ..the acute reactivity and recovery of three physiological response systems tied to the development of chronic disease (i.e...
  27. Humanized Transgenic Mice Reproduce the Disease Evolution in Severe RA
    Grete Sonderstrup; Fiscal Year: 2010
    ..with similar joint distribution as RA in humans, none of these models accurately replicates the slow, chronic disease progression with extra-articular symptoms seen in humans...
  28. Remodeling of the guinea pig intrinsic cardiac plexus with chronic heart disease
    ELIZABETH MARIE SOUTHERLAND; Fiscal Year: 2013
    ..To specifically address these points this proposal will evaluate how the elements of the ICN adapt to chronic disease using two different animal models of heart disease: myocardial infarction (MI) and chronic pressure overload (..
  29. North Lawndale Diabetes Community Action Project
    STEVEN contact WHITMAN; Fiscal Year: 2010
    ..in the neighborhood identifying persons with both confirmed diabetes status and those at high risk for the chronic disease over a 12-week recruitment period, with the intention of completing an entire 12-month intervention with 280 ..
  30. Clinical Impact of Human Coronaviruses and Viral Diversity
    Geoffrey J Gorse; Fiscal Year: 2012
    ....
  31. Experimental Molecular Vaccines for Schistosomiasis
    Afzal A Siddiqui; Fiscal Year: 2012
    ..The sum of years of life lost through disability (DALYs) because of this debilitating and chronic disease has been estimated to be 1.7 million/year...
  32. Quality Dialysis Outcomes and Practice Patterns Study (DOPPS): high-quality care
    Francesca Tentori; Fiscal Year: 2013
    ..Ikizler. Environment: Arbor Research is a not-for-profit organization that leads health outcomes studies in chronic disease and end-stage organ failure, including the DOPPS, the Scientific Registry of Transplant Recipients (SRTR), ..
  33. Prenatal stress and epigenetic programming of the HPA axis and autonomic balance
    Rosalind J Wright; Fiscal Year: 2013
    ..in key target tissues accessible at time of birth and previously linked to prenatal stress and/or chronic disease. Leveraging the Harvard PRogramming of Intergenerational Stress Mechanisms (PRISM) study, a funded prenatal ..
  34. TAM receptor tyrosine kinases in inflammatory bowel disease
    Carla Rothlin; Fiscal Year: 2013
    ..approaches need to be developed to facilitate the early diagnosis and therapeutic management of this chronic disease. Our studies focus on a novel, yet fundamental anti-inflammatory signaling pathway - TAM pathway - in antigen ..
  35. Role of T Cell Mediated Immunity In Emotion And Stress Responsiveness
    Leonardo H Tonelli; Fiscal Year: 2012
    ..This may advance the understanding of mind-body interaction and lead to the development of new strategies of interventions to improve the treatment of mental disorders in chronically ill patients. ..
  36. Nutrition and Physical Activity Assessment Study (NPAAS)
    Ross L Prentice; Fiscal Year: 2013
    ..This work addresses fundamental gaps in diet and physical activity epidemiology research, in the context of national and international obesity epidemics, and in much related chronic disease morbidity and mortality.
  37. Growth and Cardiometabolic Risk Among In Utero Drug Exposed Children
    SARAH ELIZABETH MESSIAH; Fiscal Year: 2013
    ..and cardiometabolic disease risk factor development in childhood and subsequent risk for adult onset chronic disease)...
  38. Enhancing Nrf2 by Sulforaphane Treatment in COPD
    Robert A Wise; Fiscal Year: 2012
    ..Disease (COPD) is a major cause of morbidity and mortality in the United States and is a growing cause of chronic disease internationally...
  39. An Innovative Endoscopic Instrument with Full-Field Viewing and Intelligent Imagi
    STEVEN YI; Fiscal Year: 2010
    ..for the next generation cystoscopy, neuroendoscopy, laparoscopy, etc. Non-medical fields to benefit this technology include commercial perimeter surveillance, and water and gas pipe inspection - another multi-billion market. ..
  40. Nutrition, Deregulation of Imprinted Genes
    Cathrine Hoyo; Fiscal Year: 2013
    ..Despite the seeming importance of imprinted genes in obesity and adult-onset chronic disease, the population frequency of, and risk factors associated with deregulation (aberrant methylation and loss of ..
  41. The Impact of Oxidative Stress on HIV-induced Lung Disease
    Jesse Roman; Fiscal Year: 2013
    ..Currently antiretroviral therapy (ART) has changed HIV into a chronic disease. In the pre-ART era, pulmonary infections were very common...
  42. Identifying a role for commensal bacteria on the liver immune priming environment
    Jean Publicover; Fiscal Year: 2013
    ..developing a chronic infection varies depending on the age at the time of exposure with a predisposition to chronic disease outcome when one is infected as an infant or child...
  43. The Vaginal Microbiome: Disease, Genetics and the Environment
    GREGORY ALLEN BUCK; Fiscal Year: 2012
    ..states of the host? We hypothesize that "altered" physiologic (pregnancy, menopause) and pathologic (chronic disease, hysterectomy) conditions, or environmental "exposures" (exogenous hormones, antibiotics, chronic ..
  44. Cardiovascular Health: Effects of the Social and Physical Environment
    Shakira Franco Suglia; Fiscal Year: 2013
    ..Findings from these studies can inform clinical practice in chronic disease prevention so that providers and policymakers alike can tailor age appropriate interventions to adolescents ..
  45. Regulation of IL4 signal transduciton by poly (ADP-ribose) polymerase-1.
    Rahul Datta; Fiscal Year: 2011
    ..Environmental conditions have been shown to correlate chronic disease incidence as well as triggering actual asthmatic episodes...
  46. Neural basis of learned food aversion and nausea
    CHARLES HORN; Fiscal Year: 2009
    ..Effective treatment of nausea may substantially improve the quality of life for patients with chronic disease.
  47. Study of the HFE Transferrin Receptor interaction in mammalian iron homeostasis
    Paul Schmidt; Fiscal Year: 2010
    ..of human iron disorders including hereditary hemochromatosis, iron-limited anemia, and anemia caused by chronic disease. It may inform new therapeutic strategies...
  48. A new experimental model of knee joint trauma
    TAMMY L HAUTDONAHUE; Fiscal Year: 2012
    ..surgical reconstruction after traumatic rupture there is a significant increase in the risk of a long term, chronic disease called osteoarthritis (OA)...
  49. Mechanisms of abnormal enterochromaffin cell secretion in Crohn's disease
    Mark S Kidd; Fiscal Year: 2012
    ..Crohn's is a common and chronic disease that substantially reduces quality of life...
  50. Inflammasome Activation in Complex Regional Pain Syndrome
    Wade S Kingery; Fiscal Year: 2013
    ..Activation of the innate system of immunity in skin initiates the cascade of changes supporting this chronic disease. This research proposal outlines a vertically integrated set of experiments all focused on the central ..
  51. Reforming Medicare: Beneficiary Choice, Plan Payment, and Accountable Care
    JOHN MICHAEL MCWILLIAMS; Fiscal Year: 2012
    ..With the population aging, burden of chronic disease rising, and health-care costs growing at an unsustainable rate, the Medicare program faces an enormous ..
  52. Inflammatory Cytokine regulation of POMC and Orexin neurons in cachexia.
    AARON GROSSBERG; Fiscal Year: 2012
    ..research will evaluate whether leukemia inhibitory factor (LIF), an inflammatory cytokine elevated in chronic disease, reduces food intake and increases metabolic rate by directly activating proopiomelanocortin (POMC) neurons ..
  53. 1st Tier Drugs+Theophylline in Pediatric Severe Asthma
    JERRY JOHN ZIMMERMAN; Fiscal Year: 2010
    Asthma is the most common childhood chronic disease affecting nearly 15 million children, and represents the most common cause of hospitalization among children in the United States, nearly 500,000 annually...
  54. Training in Environmental Health to Reduce Chronic Disease in Latin America
    Philip J Landrigan; Fiscal Year: 2013
    ..Examples are: 1) asthma, the most common chronic disease in children is caused or aggravated by environmental factors including indoor allergens, air pollution and ..
  55. Diet and Activity Promotion Among Older Working Adults
    Gladys Block; Fiscal Year: 2010
    ..and cost-effective methods are needed to improve these behaviors in this age group, a group with increasing chronic disease and impending Medicare use...
  56. Cancer Care among Medicare HIV patients
    Sumedha Chhatre; Fiscal Year: 2011
    ..Conclusions: The AIDS epidemic is entering a chronic disease phase...
  57. VitaminA and Sickle Cell Disease:Improving Suboptimal Status with Supplementation
    KELLY ANN DOUGHERTY; Fiscal Year: 2013
    ..Her career development will be guided by an accomplished team of investigators in nutrition, growth, chronic disease, stable isotope assessment, ophthalmology, epidemiology / study design and biostatistics...
  58. Regulation of SKN-1 functions by insulin-like signaling in C. elegans
    THOMAS KEITH BLACKWELL; Fiscal Year: 2013
    ..PUBLIC HEALTH RELEVANCE: An understanding of mechanisms that increase productive lifespan and protect against chronic disease may provide the greatest cost/benefit ratio of any area of biomedical research...
  59. Characterization of a Novel Erythropoietin Signaling Pathway
    Adam N Goldfarb; Fiscal Year: 2013
    ..Another topic listed is "Anemia of Inflammation and Chronic Disease." Improved understanding of normal erythroid EpoR signaling is a critical first step toward understanding the ..
  60. A novel vaccine to prevent HCV infection and hence liver cancer
    Ellen S Vitetta; Fiscal Year: 2010
    ..Although some individuals clear the infection, many progress to chronic disease and years later can get liver cancer...
  61. Dental Caries: Whole Genome Association and Gene x Environment Studies
    Mary L Marazita; Fiscal Year: 2010
    Dental caries (also known as tooth decay) remains the most common chronic disease of childhood...
  62. Development of A Novel Anti-Hyperglycemic Agent
    Zhaoping Li; Fiscal Year: 2012
    ..PUBLIC HEALTH RELEVANCE: Relevance to the Veterans Health Diabetes is a difficult and challenging chronic disease, and the seventh leading cause of death in the US (61). The DVA provides healthcare service to about 5...
  63. Hypertension Pharmacogenetics
    Julie Johnson; Fiscal Year: 2006
    DESCRIPTION (provided by applicant): Hypertension (HTN) is the most common chronic disease in the United States, and is a leading cause of stroke, acute myocardial infarction (MI), heart failure and kidney failure...
  64. Harnessing Health IT for Self-Management Support and Medication Activation in a M
    Dean Schillinger; Fiscal Year: 2009
    ..Receipt of ATSM was associated with robust improvements in patient-centered dimensions of chronic disease care, including assessment of chronic illness care, interpersonal communication, self-efficacy, and ..
  65. XV INTERNATIONAL CONGRESS OF NUTRITION
    RICHARD ALLISON; Fiscal Year: 1993
    ..is the scientific leader in nutrition research relevant to world problems including relationships of diet and chronic disease as well as consequences of nutrient deficiencies...
  66. Using a Telemedicine System to Promote Patient Care Among Underserved Individuals
    Alfred Bove; Fiscal Year: 2009
    ..Patient-Centered Care (PCC) has been implemented for acute ambulatory settings. However, chronic disease management and prevention presents some unique challenges for PCC since the patient is followed by episodic ..
  67. TAHLC:Texting to promote Adolescent Health Liaisons & Chronic disease Management
    Jeannie S Huang; Fiscal Year: 2010
    This application, entitled TAHLC (Texting to promote Adolescent Health Liaisons and Chronic disease management), addresses broad Challenge Area (06) Enabling Technologies and specific Challenge Topic, 06- MD-101* Development of ..
  68. Behavioral Health Informatics Capacity-Building in China
    Robert Friedman; Fiscal Year: 2009
    ..Ji Peng, Chief of the Department of Chronic Disease Prevention and Control in the Shenzhen Municipal Center for Chronic Disease Prevention and Control in ..
  69. PROVIDING TELE HOME CARE TO CHRONICALLY ILL RURAL OLDER
    Pamela Whitten; Fiscal Year: 2000
    ..Most importantly, this research may serve as an important contributor to policy makers as home health care legislation evolves. ..
  70. A Comparison of Provider Versus Health Plan Delivered Care Management in Michigan
    Jodi Summers Holtrop; Fiscal Year: 2010
    ..five selected physician organizations (POs), will begin a demonstration project to test provider-delivered chronic disease care management (PDCM). At the same time, BCBSM will continue to deliver their health plan-based (i.e...
  71. Preventing Depression in People with Epilepsy: An Extension of Project UPLIFT
    Nancy J Thompson; Fiscal Year: 2010
    ..It describes an intervention to prevent depression, a significant chronic disease, among a specific disparity population: people with epilepsy...
  72. A Secular Change in Menstrual Characteristicis of Adult and Midlife Women?
    Sioban D Harlow; Fiscal Year: 2010
    ..function and have been associated with fertility, age at menopause, and women's long term risk of chronic disease. Given the secular change in risk factors that influence menstrual function, including body size, smoking, ..
  73. Neuroimaging of MS - State of the Art and Future Directions
    Oded Gonen; Fiscal Year: 2009
    ..MS is a chronic disease afflicting the central nervous system (CNS) of young adults and can last decades...
  74. 'Social Influence and Self-management Behaviors Among O*
    Megan Lewis; Fiscal Year: 2001
    ..Patients and spouses must engage in these self-management behaviors on a daily basis to stem progression of chronic disease. This study will examine the association between older married couples' social interactions and their success ..
  75. Using HIT to Improve Ambulatory Chronic Disease Care
    David Mehr; Fiscal Year: 2009
    DESCRIPTION: (PROVIDED BY APPLICANT): While chronic disease care consumes an increasing share of healthcare resources, management of chronic illnesses is often fragmented and ineffective...
  76. Web-based, Patient-centered Approach to CVD Risk-factor Management and Reduction
    Jeffrey A Henderson; Fiscal Year: 2010
    ..Poor dietary and physical activity habits and adherence with prescribed therapies and instructions for chronic disease management are several important behaviors that can place an individual at increased risk of CVD and, in turn,..
  77. A Telephone-Based Cancer Education & Prevention Intervention for Teens
    KENNETH TERCYAK; Fiscal Year: 2007
    ..inactivity, overweight, and alcohol consumption top the list of lifestyle and behavioral cancer and chronic disease risk factors...
  78. UNINTENDED OUTCOMES OF HEALTH CARE COST CONTAINMENT
    Stephen Soumerai; Fiscal Year: 1990
    ..Findings will be relevant to future policy decisions whose goal is to contain health care costs without sacrificing quality of care...
  79. SELF-CARE AND COMPLIANCE OF CHRONICALLY ILL AGED
    Linda Belgrave; Fiscal Year: 1992
    ..This research is based on a conceptual model that combines the perception of the chronic disease experience, factors in the health belief model that have been found to be consistent predictors of illness ..