acute disease

Summary

Summary: Disease having a short and relatively severe course.

Top Publications

  1. ncbi Acute kidney injury, mortality, length of stay, and costs in hospitalized patients
    Glenn M Chertow
    Division of Nephrology, Department of Medicine, University of California San Francisco, 94118 1211, USA
    J Am Soc Nephrol 16:3365-70. 2005
  2. pmc Graft-versus-host disease
    James L M Ferrara
    University of Michigan, Pediatrics and Internal Medicine, Blood and Marrow Transplantation Program, Ann Arbor, MI 48109 5942, USA
    Lancet 373:1550-61. 2009
  3. pmc Foodborne illness acquired in the United States--unspecified agents
    Elaine Scallan
    Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    Emerg Infect Dis 17:16-22. 2011
  4. ncbi Molecular classification of cancer: class discovery and class prediction by gene expression monitoring
    T R Golub
    Whitehead Institute Massachusetts Institute of Technology Center for Genome Research, Cambridge, MA 02139, USA
    Science 286:531-7. 1999
  5. ncbi The Banff 97 working classification of renal allograft pathology
    L C Racusen
    Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Kidney Int 55:713-23. 1999
  6. doi Amoxicillin for acute lower-respiratory-tract infection in primary care when pneumonia is not suspected: a 12-country, randomised, placebo-controlled trial
    Paul Little
    Primary Care and Population Sciences Division, University of Southampton, Southampton, UK
    Lancet Infect Dis 13:123-9. 2013
  7. ncbi Prognostically useful gene-expression profiles in acute myeloid leukemia
    Peter J M Valk
    Department of Hematology, Erasmus University Medical Center, Rotterdam, The Netherlands
    N Engl J Med 350:1617-28. 2004
  8. pmc Gene expression patterns in blood leukocytes discriminate patients with acute infections
    Octavio Ramilo
    Baylor National Institute of Allergy and Infections Diseases NIAID Cooperative Center for Translational Research on Human Immunology and Biodefense and Baylor Institute for Immunology Research, Dallas, TX 75204, USA
    Blood 109:2066-77. 2007
  9. doi Acute pancreatitis
    Jean Louis Frossard
    Division de Gastroenterologie, Hopitaux Universitaires de Geneve, Geneva, Switzerland
    Lancet 371:143-52. 2008
  10. ncbi The outcome of acute hepatitis C predicted by the evolution of the viral quasispecies
    P Farci
    Department of Medical Sciences, University of Cagliari, Via San Giorgio 12, 09124 Cagliari, Italy
    Science 288:339-44. 2000

Detail Information

Publications373 found, 100 shown here

  1. ncbi Acute kidney injury, mortality, length of stay, and costs in hospitalized patients
    Glenn M Chertow
    Division of Nephrology, Department of Medicine, University of California San Francisco, 94118 1211, USA
    J Am Soc Nephrol 16:3365-70. 2005
    ..Moreover, outcomes are related directly to the severity of acute kidney injury, whether characterized by nominal or percentage changes in serum creatinine...
  2. pmc Graft-versus-host disease
    James L M Ferrara
    University of Michigan, Pediatrics and Internal Medicine, Blood and Marrow Transplantation Program, Ann Arbor, MI 48109 5942, USA
    Lancet 373:1550-61. 2009
    ..We also summarise supportive-care measures that are essential for management of this medically fragile population...
  3. pmc Foodborne illness acquired in the United States--unspecified agents
    Elaine Scallan
    Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    Emerg Infect Dis 17:16-22. 2011
    ..8-61.2 million) episodes of domestically acquired foodborne illness were caused by unspecified agents, resulting in 71,878 hospitalizations (90% CrI 9,924-157,340) and 1,686 deaths (90% CrI 369-3,338)...
  4. ncbi Molecular classification of cancer: class discovery and class prediction by gene expression monitoring
    T R Golub
    Whitehead Institute Massachusetts Institute of Technology Center for Genome Research, Cambridge, MA 02139, USA
    Science 286:531-7. 1999
    ....
  5. ncbi The Banff 97 working classification of renal allograft pathology
    L C Racusen
    Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Kidney Int 55:713-23. 1999
    ..This manuscript describes a classification, Banff 97, developed by investigators using the Banff Schema and the Collaborative Clinical Trials in Transplantation (CCTT) modification for diagnosis of renal allograft pathology...
  6. doi Amoxicillin for acute lower-respiratory-tract infection in primary care when pneumonia is not suspected: a 12-country, randomised, placebo-controlled trial
    Paul Little
    Primary Care and Population Sciences Division, University of Southampton, Southampton, UK
    Lancet Infect Dis 13:123-9. 2013
    ..We aimed to compare the benefits and harms of amoxicillin for acute lower-respiratory-tract infection with those of placebo both overall and in patients aged 60 years or older...
  7. ncbi Prognostically useful gene-expression profiles in acute myeloid leukemia
    Peter J M Valk
    Department of Hematology, Erasmus University Medical Center, Rotterdam, The Netherlands
    N Engl J Med 350:1617-28. 2004
    ..However, this combined approach provides correct therapeutic and prognostic information in only 50 percent of cases...
  8. pmc Gene expression patterns in blood leukocytes discriminate patients with acute infections
    Octavio Ramilo
    Baylor National Institute of Allergy and Infections Diseases NIAID Cooperative Center for Translational Research on Human Immunology and Biodefense and Baylor Institute for Immunology Research, Dallas, TX 75204, USA
    Blood 109:2066-77. 2007
    ..Thus, microarray analyses of patient peripheral blood leukocytes might assist in the differential diagnosis of infectious diseases...
  9. doi Acute pancreatitis
    Jean Louis Frossard
    Division de Gastroenterologie, Hopitaux Universitaires de Geneve, Geneva, Switzerland
    Lancet 371:143-52. 2008
    ..Improved understanding of pathophysiology and better assessments of disease severity should ameliorate the management and outcome of this complex disease...
  10. ncbi The outcome of acute hepatitis C predicted by the evolution of the viral quasispecies
    P Farci
    Department of Medical Sciences, University of Cagliari, Via San Giorgio 12, 09124 Cagliari, Italy
    Science 288:339-44. 2000
    ..These data indicate that the evolutionary dynamics of the HCV quasispecies during the acute phase of hepatitis C predict whether the infection will resolve or become chronic...
  11. pmc Quantitative analysis of cellular inflammation after traumatic spinal cord injury: evidence for a multiphasic inflammatory response in the acute to chronic environment
    Kevin D Beck
    Anatomy and Neurobiology, University of California, Irvine, CA 92697 4292, USA
    Brain 133:433-47. 2010
    ....
  12. pmc Muscle force during an acute exacerbation in hospitalised patients with COPD and its relationship with CXCL8 and IGF-I
    M A Spruit
    Respiratory Rehabilitation and Respiratory Division, University Hospital Gasthuisberg, Herestraat 49, 3000 Leuven, Belgium
    Thorax 58:752-6. 2003
    ..The effect of an acute exacerbation on quadriceps peak torque (QPT) was therefore studied in hospitalised patients, and the aforementioned correlations were examined in hospitalised and in stable patients...
  13. ncbi Acute colitis induced by dextran sulfate sodium progresses to chronicity in C57BL/6 but not in BALB/c mice: correlation between symptoms and inflammation
    Silvia Melgar
    AstraZeneca R and D Molndal, Dept of Integrative Pharmacology, GI Biology, SE 431 83 Molndal, Sweden
    Am J Physiol Gastrointest Liver Physiol 288:G1328-38. 2005
    ..We believe that the present protocol to induce chronic colitis in C57BL/6 mice offers a robust model for validating future therapies for treatment of inflammatory bowel disease...
  14. pmc Variation in antibiotic prescribing and its impact on recovery in patients with acute cough in primary care: prospective study in 13 countries
    C C Butler
    Department of Primary Care and Public Health, School of Medicine, Cardiff University, Cardiff CF14 4XN, Wales
    BMJ 338:b2242. 2009
    ..To describe variation in antibiotic prescribing for acute cough in contrasting European settings and the impact on recovery...
  15. ncbi Massive infection and loss of memory CD4+ T cells in multiple tissues during acute SIV infection
    Joseph J Mattapallil
    Immunotechnology Section, Vaccine Research Center, NIAID, NIH, Bethesda, Maryland 20892, USA
    Nature 434:1093-7. 2005
    ..Our findings point to the importance of reducing the cell-associated viral load during acute infection through therapeutic or vaccination strategies...
  16. ncbi Association of hemoglobin levels with clinical outcomes in acute coronary syndromes
    Marc S Sabatine
    TIMI Study Group, Cardiovascular Division, Brigham and Women s Hospital, Boston, Mass 02115, USA
    Circulation 111:2042-9. 2005
    ..In the setting of an acute coronary syndrome (ACS), anemia has the potential to worsen myocardial ischemia; however, data relating anemia to clinical outcomes in ACS remain limited...
  17. pmc EULAR evidence based recommendations for gout. Part II: Management. Report of a task force of the EULAR Standing Committee for International Clinical Studies Including Therapeutics (ESCISIT)
    W Zhang
    Academic Rheumatology, University of Nottingham, Clinical Sciences Building, City Hospital, Nottingham NG5 1PB, UK
    Ann Rheum Dis 65:1312-24. 2006
    ..To develop evidence based recommendations for the management of gout...
  18. pmc Acute hepatitis C virus infection in young adult injection drug users: a prospective study of incident infection, resolution, and reinfection
    Kimberly Page
    Department of Epidemiology and Biostatistics, University of California, San Francisco, 50 Beale St, Ste 1200, San Francisco, CA 94105, USA
    J Infect Dis 200:1216-26. 2009
    ..Hepatitis C virus (HCV) infection, clearance, and reinfection are best studied in injection drug users (IDUs), who have the highest incidence of HCV and are likely to represent most infections...
  19. pmc Acute exacerbations of idiopathic pulmonary fibrosis
    Harold R Collard
    Department of Medicine, San Francisco General Hospital, University of California, USA
    Am J Respir Crit Care Med 176:636-43. 2007
    ..The potential pathobiological roles of infection, disordered cell biology, coagulation, and genetics are discussed, and future research directions are proposed...
  20. ncbi Delayed enhancement and T2-weighted cardiovascular magnetic resonance imaging differentiate acute from chronic myocardial infarction
    Hassan Abdel-Aty
    Franz Volhard Klinik, HELIOS Klinikum Berlin, Kardiologie, Charité Campus Berlin Buch, Humboldt Universitat zu Berlin, Berlin, Germany
    Circulation 109:2411-6. 2004
    ..T2-weighted CMR depicts infarct-related myocardial edema as a marker of acute but not chronic myocardial injury. We investigated the clinical utility of an approach combining both techniques to differentiate acute from chronic MI...
  21. ncbi Dynamics of language reorganization after stroke
    Dorothee Saur
    Department of Neurology, University Freiburg, Breisacher Strasse 64, 79106 Freiburg, Germany
    Brain 129:1371-84. 2006
    ..Thereafter, a normalization of activation is observed, possibly reflecting consolidation in the language system...
  22. ncbi Recent epidemic of acute hepatitis C virus in HIV-positive men who have sex with men linked to high-risk sexual behaviours
    Mark Danta
    UCL Institute of Hepatology, London, UK
    AIDS 21:983-91. 2007
    ..To characterize the mode of hepatitis C virus (HCV) transmission in a recent epidemic of acute HCV in HIV-infected individuals using linked molecular and clinical epidemiological studies...
  23. ncbi Efficacy of a pneumococcal conjugate vaccine against acute otitis media
    J Eskola
    National Public Health Institute, Helsinki, Finland
    N Engl J Med 344:403-9. 2001
    ..CONCLUSIONS: The heptavalent pneumococcal polysaccharide-CRM197 conjugate vaccine is safe and efficacious in the prevention of acute otitis media caused by the serotypes included in the vaccine...
  24. doi Probiotic prophylaxis in predicted severe acute pancreatitis: a randomised, double-blind, placebo-controlled trial
    Marc G H Besselink
    Department of Surgery, University Medical Center Utrecht, Utrecht, Netherlands
    Lancet 371:651-9. 2008
    ..Enteral administration of probiotics could prevent infectious complications, but convincing evidence is scarce. Our aim was to assess the effects of probiotic prophylaxis in patients with predicted severe acute pancreatitis...
  25. doi Effect of the Italian smoking ban on population rates of acute coronary events
    Giulia Cesaroni
    Department of Epidemiology, Local Health Unit ASL RME, Via Santa Costanza 53, 00198 Rome, Italy
    Circulation 117:1183-8. 2008
    ..We evaluated changes in the frequency of acute coronary events in Rome, Italy, after the introduction of legislation that banned smoking in all indoor public places in January 2005...
  26. ncbi Pneumococcal capsular polysaccharides conjugated to protein D for prevention of acute otitis media caused by both Streptococcus pneumoniae and non-typable Haemophilus influenzae: a randomised double-blind efficacy study
    Roman Prymula
    Department of Epidemiology, Faculty of Military Health Sciences, University of Defence, Hradec Kralove, Czech Republic
    Lancet 367:740-8. 2006
    ..This study assessed the efficacy of a novel vaccine that contained polysaccharides from 11 different Streptococcus pneumoniae serotypes each conjugated to Haemophilus influenzae-derived protein D in prevention of acute otitis media...
  27. pmc Donor-type CD4(+)CD25(+) regulatory T cells suppress lethal acute graft-versus-host disease after allogeneic bone marrow transplantation
    Petra Hoffmann
    Division of Immunology and Rheumatology, Department of Medicine, Stanford University School of Medicine, CA 94305, USA
    J Exp Med 196:389-99. 2002
    ..Our results demonstrate that the balance of donor-type CD4(+)CD25(+) T(reg) and conventional CD4(+)CD25(-) T cells can determine the outcome of aGVHD...
  28. pmc Antibiotics as part of the management of severe acute malnutrition
    Indi Trehan
    Department of Pediatrics, Washington University in St Louis, St Louis, MO 63110, USA
    N Engl J Med 368:425-35. 2013
    ..Adding routine antibiotic agents to nutritional therapy may increase recovery rates and decrease mortality among children with severe acute malnutrition treated in the community...
  29. pmc Sequential bottlenecks drive viral evolution in early acute hepatitis C virus infection
    Rowena A Bull
    School of Medical Sciences, University of New South Wales, Australia
    PLoS Pathog 7:e1002243. 2011
    ..These results provide the first detailed analysis of early within-host evolution of HCV, indicating strong selective forces limit viral evolution in the acute phase of infection...
  30. pmc Human metapneumovirus infections in hospitalized children
    Guy Boivin
    Centre Hospitalier Universitaire de Quebec, Quebec City, Canada
    Emerg Infect Dis 9:634-40. 2003
    ..HMPV is an important cause of illness in young children with a similar, although less severe, clinical presentation to that of HRSV...
  31. doi The regulatory T-cell response during acute retroviral infection is locally defined and controls the magnitude and duration of the virus-specific cytotoxic T-cell response
    Gennadiy Zelinskyy
    Institute for Virology, University Clinics in Essen, University of Duisburg Essen, Essen, Germany
    Blood 114:3199-207. 2009
    ....
  32. pmc Prospective study of the incidence, aetiology and outcome of adult lower respiratory tract illness in the community
    J Macfarlane
    Respiratory Infection Group, Nottingham City Hospital, Nottingham NG5 1PB, UK
    Thorax 56:109-14. 2001
    ..Viral infection is thought to be the cause in most cases. We have investigated the incidence, aetiology, and outcome of this condition...
  33. doi Effect of nesiritide in patients with acute decompensated heart failure
    C M O'Connor
    Duke Clinical Research Institute, Duke University Medical Center, Durham, North Carolina 27710, USA
    N Engl J Med 365:32-43. 2011
    ..Nesiritide is approved in the United States for early relief of dyspnea in patients with acute heart failure. Previous meta-analyses have raised questions regarding renal toxicity and the mortality associated with this agent...
  34. doi Haemophilus influenzae and Haemophilus haemolyticus in tonsillar cultures of adults with acute pharyngotonsillitis
    Muneki Hotomi
    Department of Otolaryngology Head and Neck Surgery, Wakayama Medical University, 811 1 Kimiidera, Wakayama Shi, Wakayama, 640 8501, Japan
    Auris Nasus Larynx 37:594-600. 2010
    ..The aim of this study was to evaluate the clinical implication of Haemophilus haemolyticus, one of the closest relative of Haemophilus influenzae, on acute pharyngotonsillitis...
  35. ncbi EuroHeart Failure Survey II (EHFS II): a survey on hospitalized acute heart failure patients: description of population
    Markku S Nieminen
    Division of Cardiology, Department of Medicine, Helsinki University Central Hospital, Haartmaninkatu 4, PO Box 340, 00029 HUS, Finland
    Eur Heart J 27:2725-36. 2006
    ....
  36. pmc Evidence of a large, international network of HCV transmission in HIV-positive men who have sex with men
    Thijis van de Laar
    Cluster of Infectious Diseases, Health Service, Amsterdam, The Netherlands
    Gastroenterology 136:1609-17. 2009
    ..We conducted an international phylogenetic study to investigate the existence of an HCV transmission network among MSM...
  37. ncbi Type III protein secretion is associated with death in lower respiratory and systemic Pseudomonas aeruginosa infections
    A Roy-Burman
    Department of Anesthesia and Perioperative Care, Cardiovascular Research Institute, University of California, San Francisco, CA 94143-0542, USA
    J Infect Dis 183:1767-74. 2001
    ..A positive phenotype is a predictor of poor clinical outcome. In the future, such analyses may help distinguish potentially lethal infection from colonization and help determine appropriate therapy for critically ill patients...
  38. pmc Antibiotic prescription rates for acute respiratory tract infections in US ambulatory settings
    Carlos G Grijalva
    Department of Preventive Medicine, Vanderbilt University School of Medicine, 1500 21st Ave, Ste 2600, The Village at Vanderbilt, Nashville, TN 37232 2637, USA
    JAMA 302:758-66. 2009
    ..During the 1990s, antibiotic prescriptions for acute respiratory tract infection (ARTI) decreased in the United States. The sustainability of those changes is unknown...
  39. ncbi Practice guidelines for the diagnosis and management of group A streptococcal pharyngitis. Infectious Diseases Society of America
    Alan L Bisno
    Department of Medicine, University of Miami School of Medicine and Veterans Affairs Medical Center, Miami, FL 33125, USA
    Clin Infect Dis 35:113-25. 2002
  40. ncbi Clinical practice. Acute pancreatitis
    David C Whitcomb
    Division of Gastroenterology, Hepatology, and Nutrition, University of Pittsburgh, Pittsburgh, PA 15213, USA
    N Engl J Med 354:2142-50. 2006
  41. doi Guidelines on the diagnosis and management of acute pulmonary embolism: the Task Force for the Diagnosis and Management of Acute Pulmonary Embolism of the European Society of Cardiology (ESC)
    Adam Torbicki
    Department of Chest Medicine, Institute for Tuberculosis and Lung Diseases, Warsaw, Poland
    Eur Heart J 29:2276-315. 2008
    ..With the exception of severe air and fat embolism, the haemodynamic consequences of non-thrombotic emboli are usually mild. Treatment is mostly supportive but may differ according to the type of embolic material and clinical severity...
  42. ncbi Diagnostic performance of cardiovascular magnetic resonance in patients with suspected acute myocarditis: comparison of different approaches
    Hassan Abdel-Aty
    Franz Volhard Klinik, Charite Campus Buch, Universität Medizin Berlin, Berlin, Germany
    J Am Coll Cardiol 45:1815-22. 2005
    ..The aim of this research was to identify the diagnostic performance of gadolinium-enhanced and T2-weighted cardiovascular magnetic resonance (CMR) in suspected acute myocarditis...
  43. ncbi Analysis of a successful immune response against hepatitis C virus
    S Cooper
    Department of Structural Biology, Stanford University School of Medicine, California 94305 5400, USA
    Immunity 10:439-49. 1999
    ..Every specificity shown during acute hepatitis persisted in normal liver tissue more than 1 yr after resolution. These results suggest that CD8+CTL are better correlated with protection against HCV infection than antibodies...
  44. ncbi Multidetector computed tomography for acute pulmonary embolism
    Paul D Stein
    Department of Research, St Joseph Mercy Oakland Hospital, Pontiac, Mich, USA
    N Engl J Med 354:2317-27. 2006
    ..The accuracy of multidetector computed tomographic angiography (CTA) for the diagnosis of acute pulmonary embolism has not been determined conclusively...
  45. ncbi Acute pain in herpes zoster and its impact on health-related quality of life
    Jennifer Katz
    Department of Anesthesiology, University of Rochester School of Medicine and Dentistry, Rochester, NY, 14642, USA
    Clin Infect Dis 39:342-8. 2004
    ..The increasing incidence of herpes zoster that can be anticipated as the population ages requires that clinical trials that examine interventions to prevent or treat herpes zoster pain be given a high priority...
  46. ncbi Virological features and clinical manifestations associated with human metapneumovirus: a new paramyxovirus responsible for acute respiratory-tract infections in all age groups
    Guy Boivin
    Research Center in Infectious Diseases, Regional Virology Laboratory, Laval University, Quebec City, Canada
    J Infect Dis 186:1330-4. 2002
    ..These findings suggest that HMPV can be associated with severe lower-respiratory-tract infections in very young children, the elderly, and immunocompromised patients...
  47. ncbi Elevated high-mobility group box 1 levels in patients with cerebral and myocardial ischemia
    Richard S Goldstein
    Department of Emergency Medicine, North Shore University Hospital, North Shore LIJ, Manhasset, NY 11030, USA
    Shock 25:571-4. 2006
    ..8+/-10.9 ng/mL, vs. cerebral ischemia serum HMGB1, 218+/-18.8 ng/mL; P<0.001). These results suggest that systemic HMGB1 levels are elevated in human ischemic disease...
  48. pmc Variations in antibiotic prescribing and consultation rates for acute respiratory infection in UK general practices 1995-2000
    Mark Ashworth
    STaRNet lead general practitioner and honorary senior lecturer, King s College London
    Br J Gen Pract 55:603-8. 2005
    ..Antibiotic prescribing by GPs in the UK has declined since 1995...
  49. doi Outcome of subclinical antibody-mediated rejection in kidney transplant recipients with preformed donor-specific antibodies
    A Loupy
    INSERM UMR 872, Universite Paris Descartes, Paris, France
    Am J Transplant 9:2561-70. 2009
    ..C4d-negative SAMR patients displayed an intermediate course between the no-SAMR group and the C4d+ SAMR group. Screening biopsies may be useful to recognize patients more likely to develop SAMR...
  50. pmc A previously unknown reovirus of bat origin is associated with an acute respiratory disease in humans
    Kaw Bing Chua
    National Public Health Laboratory, Selangor 4700, Malaysia
    Proc Natl Acad Sci U S A 104:11424-9. 2007
    ..These data indicate that bat-borne reoviruses can be transmitted to and cause clinical diseases in humans...
  51. pmc Determinants of viral clearance and persistence during acute hepatitis C virus infection
    R Thimme
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10550 North Torrey Pines Rd, La Jolla, CA 92037, USA
    J Exp Med 194:1395-406. 2001
    ....
  52. doi Acute heart failure syndromes
    Mihai Gheorghiade
    Division of Cardiology, Department of Medicine, Northwestern University Feinberg School of Medicine, 676 N St Clair, Chicago, IL 60611, USA
    J Am Coll Cardiol 53:557-73. 2009
    ..Further investigation into pathophysiologic targets and novel approaches to clinical trial design are needed. Improving post-discharge outcomes is the single most important goal in the management of acute heart failure syndromes...
  53. pmc Food-related illness and death in the United States
    P S Mead
    Division of Bacterial and Mycotic Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Emerg Infect Dis 5:607-25. 1999
    ..Overall, foodborne diseases appear to cause more illnesses but fewer deaths than previously estimated...
  54. ncbi Decitabine improves patient outcomes in myelodysplastic syndromes: results of a phase III randomized study
    Hagop Kantarjian
    Department of Leukemia, University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer 106:1794-803. 2006
    ..Decitabine indirectly depletes methylcytosine and causes hypomethylation of target gene promoters...
  55. pmc Modeling sequence evolution in acute HIV-1 infection
    Ha Youn Lee
    Theoretical Biology and Biophysics, Los Alamos National Laboratory, Los Alamos, NM 87545, USA
    J Theor Biol 261:341-60. 2009
    ..The model can also be applied to longitudinal patient data to estimate within-host viral evolutionary parameters...
  56. doi Respiratory syncytial virus, human bocavirus and rhinovirus bronchiolitis in infants
    F Midulla
    Department of Pediatrics, Sapienza University of Rome, Viale Regina Elena 324, 00165 Rome, Italy
    Arch Dis Child 95:35-41. 2010
    ..To investigate the prevalence of 14 viruses in infants with bronchiolitis and to study demographic and clinical differences in those with respiratory syncytial virus (RSV), human bocavirus (hBoV) and rhinovirus (RV) infection...
  57. pmc Inpatient rehabilitation specifically designed for geriatric patients: systematic review and meta-analysis of randomised controlled trials
    Stefan Bachmann
    Department of Geriatrics, Inselspital, University of Bern Hospital, Freiburgstrasse 10, CH 3010 Bern, Switzerland
    BMJ 340:c1718. 2010
    ..To assess the effects of inpatient rehabilitation specifically designed for geriatric patients compared with usual care on functional status, admissions to nursing homes, and mortality...
  58. ncbi Acute pancreatitis: bench to the bedside
    Stephen J Pandol
    Department of Medicine, Department of Veterans Affairs and University of California, Los Angeles, California, USA
    Gastroenterology 132:1127-51. 2007
  59. ncbi Support vector machine classification and validation of cancer tissue samples using microarray expression data
    T S Furey
    Department of Computer Science, University of California, Santa Cruz, Santa Cruz, CA 95064, USA
    Bioinformatics 16:906-14. 2000
    ..This analysis consists of both classification of the tissue samples, and an exploration of the data for mis-labeled or questionable tissue results...
  60. ncbi Prognostic value of troponins in acute pulmonary embolism: a meta-analysis
    Cecilia Becattini
    Medicina Interna e Cardiovascolare, Dipartimento di Medicina Interna, University of Perugia, Via G Dottori 1, 06129 Perugia, Italy
    Circulation 116:427-33. 2007
    ..Whether elevated serum troponin levels identify patients with acute pulmonary embolism at high risk of short-term mortality or adverse outcome is undefined...
  61. doi Diagnostic value of clinical features at presentation to identify serious infection in children in developed countries: a systematic review
    Ann Van den Bruel
    Department of General Practice, Katholieke Universiteit Leuven, Leuven, Belgium
    Lancet 375:834-45. 2010
    ..Our aim was to identify which clinical features have value in confirming or excluding the possibility of serious infection in children presenting to ambulatory care settings in developed countries...
  62. ncbi Acute rheumatic fever
    Jonathan R Carapetis
    Centre for International Child Health, University of Melbourne Department of Paediatrics and Murdoch Children s Research Institute, Melbourne, Australia
    Lancet 366:155-68. 2005
    ..The most effective approach for control of ARF and RHD is secondary prophylaxis, which is best delivered as part of a coordinated control programme...
  63. ncbi Community-wide vaccination with the heptavalent pneumococcal conjugate significantly alters the microbiology of acute otitis media
    Stan L Block
    Kentucky Pediatric Research, Inc, Bardstown, KY, USA
    Pediatr Infect Dis J 23:829-33. 2004
    ....
  64. pmc Myelomonocytic cell recruitment causes fatal CNS vascular injury during acute viral meningitis
    Jiyun V Kim
    Program in Molecular Pathogenesis, Helen L and Martin S Kimmel Center for Biology and Medicine, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, New York 10016, USA
    Nature 457:191-5. 2009
    ..We conclude that a CD8(+) T-cell-dependent disorder can proceed in the absence of direct T-cell effector mechanisms and rely instead on CTL-recruited myelomonocytic cells...
  65. ncbi A network-based analysis of systemic inflammation in humans
    Steve E Calvano
    Department of Surgery, UMDNJ Robert Wood Johnson Medical School, New Brunswick, New Jersey 08903, USA
    Nature 437:1032-7. 2005
    ..These findings provide insight into the regulation of global leukocyte activities as they relate to innate immune system tolerance and increased susceptibility to infection in humans...
  66. doi Relaxin for the treatment of patients with acute heart failure (Pre-RELAX-AHF): a multicentre, randomised, placebo-controlled, parallel-group, dose-finding phase IIb study
    John R Teerlink
    Section of Cardiology, San Francisco Veterans Affairs Medical Center, University of California, San Francisco, CA, USA
    Lancet 373:1429-39. 2009
    ..We assessed the dose response of relaxin's effect on symptom relief, other clinical outcomes, and safety...
  67. doi Prevalence of human respiratory viruses in adults with acute respiratory tract infections in Beijing, 2005-2007
    L Ren
    Dr Christophe Mérieux Laboratory, IPB, CAMS Fondation Mérieux and State Key Laboratory for Molecular Virology and Genetic Engineering, Institute of Pathogen Biology IPB, Chinese Academy of Medical Sciences CAMS, Beijing, China
    Clin Microbiol Infect 15:1146-53. 2009
    ..Currently, this study is the largest-scale investigation of respiratory virus infections in China with multiple agent detection, providing baseline data for further studies of respiratory virus infections in adults with ARTIs...
  68. doi Burden of acute gastrointestinal illness in Denmark 2009: a population-based telephone survey
    L Muller
    Department of Epidemiology, Statens Serum Institut, Copenhagen, Denmark
    Epidemiol Infect 140:290-8. 2012
    ..The incidence rate estimates were considerably higher when calculated from shorter recall periods...
  69. ncbi Infectious etiology of acute exacerbations of chronic bronchitis
    S Sethi
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, State University of New York at Buffalo and Department of Veterans Affairs Western New York Healthcare System, Buffalo, NY 14215, USA
    Chest 117:380S-5S. 2000
    ..Emerging evidence from molecular epidemiology and measurement of airway inflammation further support the role of bacteria in AECB. When properly defined, 80% of AECB are likely to be infectious in origin...
  70. ncbi Secular trends in incidence and 30-day case fatality of acute pancreatitis in North Jutland County, Denmark: a register-based study from 1981-2000
    A Floyd
    Dept of Clinical Epidemiology, Aalborg Hospital, Stengade 10, DK 9000 Aalborg, Denmark
    Scand J Gastroenterol 37:1461-5. 2002
    ..Reported mortality lies around 10% and has improved during the past 20 years. The incidence rate and 30-day case fatality rate of acute pancreatitis in North Jutland County, Denmark were examined for the period 1981 to 2000...
  71. pmc CD8(+) T cells mediate viral clearance and disease pathogenesis during acute hepatitis B virus infection
    Robert Thimme
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, California 92037, USA
    J Virol 77:68-76. 2003
    ....
  72. pmc Safety and efficacy of antibiotics compared with appendicectomy for treatment of uncomplicated acute appendicitis: meta-analysis of randomised controlled trials
    Krishna K Varadhan
    Division of Gastrointestinal Surgery, Nottingham Digestive Diseases Centre NIHR Biomedical Research Unit, Nottingham University Hospitals, Queen s Medical Centre, Nottingham NG7 2UH, UK
    BMJ 344:e2156. 2012
    ..To compare the safety and efficacy of antibiotic treatment versus appendicectomy for the primary treatment of uncomplicated acute appendicitis...
  73. ncbi Causes of acute, undifferentiated, febrile illness in rural Thailand: results of a prospective observational study
    C Suttinont
    Department of Medicine, Maharat Nakhon Ratchasima Hospital, Amphur Mueng, Nakhon Ratchasima Province, 30000, Thailand
    Ann Trop Med Parasitol 100:363-70. 2006
    ..Leptospirosis and rickettsioses, especially scrub typhus, were thus found to be major causes of acute, undifferentiated fever in Thai agricultural workers...
  74. doi Prediction of mortality in acute pancreatitis: a systematic review of the published evidence
    G Gravante
    Department of Hepatobiliary and Pancreatic Surgery, University Hospitals of Leicester, Leicester, UK
    Pancreatology 9:601-14. 2009
    ..In this review, we focus on studies that examined such prognostic indices in relation to predicting a fatal outcome from pancreatitis...
  75. doi Randomized clinical trial of antibiotic therapy versus appendicectomy as primary treatment of acute appendicitis in unselected patients
    J Hansson
    Department of Surgery, Sahlgrenska University Hospital, Gothenburg, Sweden
    Br J Surg 96:473-81. 2009
    ..A trial in selected men suggested that antibiotic therapy could be an alternative to appendicectomy in appendicitis. This study aimed to evaluate antibiotic therapy in unselected men and women with acute appendicitis...
  76. ncbi Transmission of hepatitis C virus among HIV-positive homosexual men and response to a 24-week course of pegylated interferon and ribavirin
    Yvonne C Gilleece
    St Stephen s Centre, Chelsea and Westminster Hospital, London, UK
    J Acquir Immune Defic Syndr 40:41-6. 2005
    ..To evaluate treatment outcome of acute hepatitis C virus (HCV) in HIV-positive individuals...
  77. pmc Comprehensive analyses of CD8+ T cell responses during longitudinal study of acute human hepatitis C
    Andrea L Cox
    Department of Medicine, Johns Hopkins Medical Institutions, Baltimore, MD 21231, USA
    Hepatology 42:104-12. 2005
    ..Supplementary material for this article can be found on the HEPATOLOGY website (http://www.interscience.wiley.com/jpages/0270-9139/suppmat/index.html)...
  78. ncbi Otitis media
    Maroeska M Rovers
    Julius Centre for Health Sciences and Primary Care, University Medical Centre, PO Box 85060, 3508 AB, Utrecht, Netherlands
    Lancet 363:465-73. 2004
    ..The ideal intervention for OM, however, does not yet exist, and an urgent need remains to explore new and creative options based on modern insights into the pathophysiology of OM...
  79. ncbi Acute mountain sickness: influence of susceptibility, preexposure, and ascent rate
    Michael Schneider
    Department of Internal Medicine, Division of Sports Medicine, University Hospital Heidelberg, Germany
    Med Sci Sports Exerc 34:1886-91. 2002
    ..We examined the interaction of various established risk factors for acute mountain sickness (AMS) in a setting relevant for mountaineering and trekking...
  80. ncbi Role of hydrogen sulfide in acute pancreatitis and associated lung injury
    Madhav Bhatia
    Department of Pharmacology, National University of Singapore, Faculty of Medicine, Bldg MD2, 18 Medical Dr, Singapore 117597, Singapore
    FASEB J 19:623-5. 2005
    ....
  81. ncbi Acute heart failure syndromes: current state and framework for future research
    Mihai Gheorghiade
    Division of Cardiology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    Circulation 112:3958-68. 2005
  82. ncbi Factors associated with seeking medical care and submitting a stool sample in estimating the burden of foodborne illness
    Elaine Scallan
    Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Foodborne Pathog Dis 3:432-8. 2006
    ..Cases of acute diarrheal illness ascertained through laboratory-based public health surveillance are likely to differ systematically from unreported cases and likely over-represent those with bloody diarrhea and longer diarrhea duration...
  83. ncbi Transmission of HIV-1 during primary infection: relationship to sexual risk and sexually transmitted infections
    David Pao
    Department of GU Medicine, Brighton and Sussex University Hospitals, Brighton, UK
    AIDS 19:85-90. 2005
    ..To study primary HIV-1 infections (PHI) using molecular and epidemiological approaches in order to assess correlates of transmission in this population...
  84. pmc Derivation and validation of a prognostic model for pulmonary embolism
    Drahomir Aujesky
    Division of General Internal Medicine, Clinical Epidemiology Center, University of Lausanne, Lausanne, Switzerland
    Am J Respir Crit Care Med 172:1041-6. 2005
    ..An objective and simple prognostic model for patients with pulmonary embolism could be helpful in guiding initial intensity of treatment...
  85. pmc Human metapneumovirus infection among children hospitalized with acute respiratory illness
    James A Mullins
    Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    Emerg Infect Dis 10:700-5. 2004
    ..Further investigations to better characterize HMPV infection and its clinical effect are needed...
  86. ncbi Acute hepatitis C: high rate of both spontaneous and treatment-induced viral clearance
    J Tilman Gerlach
    Medical Department II, Klinikum Grosshadern and Institute for Immunology, Schwabing, Munich, Germany
    Gastroenterology 125:80-8. 2003
    ..The aim of this study was to define the natural course of the disease and to contribute to the development of treatment strategies for acute hepatitis C virus...
  87. pmc CD8 epitope escape and reversion in acute HCV infection
    Joerg Timm
    Partners AIDS Research Center, Massachusetts General Hospital, Harvard Medical School, Bldg 149, 13th St, Rm 6618 B, Boston, MA 02114, USA
    J Exp Med 200:1593-604. 2004
    ..Together, these data indicate that viral escape from CD8+ T cell responses occurs during human HCV infection and that acute immune selection pressure is of sufficient magnitude to influence HCV evolution...
  88. pmc Viral upper respiratory tract infection and otitis media complication in young children
    Tasnee Chonmaitree
    Department of Pediatrics, University of Texas Medical Branch, Galveston, TX 77555 0371, USA
    Clin Infect Dis 46:815-23. 2008
    ..The incidence and characteristics of OM complicating URI due to specific viruses have not been well studied...
  89. ncbi Diagnosis of acute bacterial meningitis in children at a district hospital in sub-Saharan Africa
    J A Berkley
    Centre for Geographic Medicine Research Coast, PO Box 230, Kilifi, Kenya
    Lancet 357:1753-7. 2001
    ..We have assessed the value of non-laboratory tests and incomplete laboratory data in diagnosing childhood acute bacterial meningitis in this setting...
  90. pmc Outpatient follow-up of patients hospitalized for acute leptospirosis
    Anne Spichler
    Institute of Infectology Emilio Ribas, Sao Paulo, Brazil
    Int J Infect Dis 15:e486-90. 2011
    The outcome of leptospirosis after the resolution of acute disease, either spontaneously or after treatment, is not well described. The aim of this study was to assess the possible sequelae of acute leptospirosis after hospital discharge.
  91. ncbi Risk factors for pancreatitis following endoscopic retrograde cholangiopancreatography: a meta-analysis
    E Masci
    Gastroenterology and Endoscopic Unit, S Raffaele Hospital, Milan, Italy
    Endoscopy 35:830-4. 2003
    ..The aim of this study was to identify the most important risk factors for post-ERCP pancreatitis...
  92. pmc Antigenic diversity of enteroviruses associated with nonpolio acute flaccid paralysis, India, 2007-2009
    C Durga Rao
    Department of Microbiology and Cell Biology, Indian Institute of Science, Bangalore 560012, India
    Emerg Infect Dis 18:1833-40. 2012
    ..0% of culture-positive and -negative cases, respectively, need to be identified. Association of human enterovirus with NP-AFP requires better assessment and understanding of health risks of NPEV infections after polio elimination...
  93. doi Effectiveness and safety of Saccharomyces boulardii for acute infectious diarrhea
    Ener Cagri Dinleyici
    Eskisehir Osmangazi University, Department of Pediatric Infectious Disease and Intensive Care Unit, Eskisehir, Turkey
    Expert Opin Biol Ther 12:395-410. 2012
    ..Regarding the treatment of acute diarrhea, a few probiotics including Saccharomyces boulardii seem to be promising therapeutic agents...
  94. pmc Effect of diabetes on severity and hospital mortality in patients with acute pancreatitis: a national population-based study
    Hsiu Nien Shen
    Department of Intensive Care Medicine, Chi Mei Medical Center, Yong Kang City, Tainan, Taiwan
    Diabetes Care 35:1061-6. 2012
    ..Diabetes may increase the risk of acute pancreatitis (AP). We aimed to further investigate whether diabetes may also adversely affect outcomes of patients with AP...
  95. doi Use of data linkage to investigate the aetiology of acute lower respiratory infection hospitalisations in children
    Hannah C Moore
    Telethon Institute for Child Health Research, Centre for Child Health Research, Schools of Pathology and Laboratory Medicine, University of Western Australia, Perth, Western Australia, Australia
    J Paediatr Child Health 48:520-8. 2012
    ..To document the aetiology of acute lower respiratory infection (ALRI) hospitalisations in Western Australian children by linking population-based laboratory data with hospital morbidity data...
  96. doi Burden of acute gastroenteritis and healthcare-seeking behaviour in France: a population-based study
    D van Cauteren
    Department of Infectious Diseases, Institut de veille sanitaire French Institute for Public Health Surveillance, Saint Maurice, France
    Epidemiol Infect 140:697-705. 2012
    ..Our results indicate that there are more than 21 million episodes of AG each year in France. These results allow a more accurate interpretation of the data derived from existing AG surveillance systems...
  97. ncbi [Recent etiology and clinical features of acute viral hepatitis in a single center of Korea]
    Hyung Min Kang
    Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Korea
    Korean J Hepatol 13:495-502. 2007
    ..The aim of this study was to investigate the recent etiology and the clinical features of acute viral hepatitis in a single center of Korea...
  98. ncbi Use of B-type natriuretic peptide in the evaluation and management of acute dyspnea
    Christian Mueller
    Department of Internal Medicine, Medical Division A, University of Basel, University Hospital, Basel, Switzerland
    N Engl J Med 350:647-54. 2004
    ..B-type natriuretic peptide levels are higher in patients with congestive heart failure than in patients with dyspnea from other causes...
  99. ncbi Enhanced intestinal inflammation induced by dextran sulfate sodium in tumor necrosis factor-alpha deficient mice
    Yuji Naito
    First Department of Medicine, Kyoto Prefectural University of Medicine, Kamigyo ku, Kyoto, Japan
    J Gastroenterol Hepatol 18:560-9. 2003
    ..To further define the role of TNF-alpha in intestinal inflammation, we studied the effects of dextran sulfate sodium (DSS) administration in mice with targeted deletions of TNF-alpha gene...
  100. ncbi Peginterferon alfa-2b therapy in acute hepatitis C: impact of onset of therapy on sustained virologic response
    Sanaa M Kamal
    Division of Gastroenterology and Liver Disease Center, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
    Gastroenterology 130:632-8. 2006
    ..Pegylated interferon therapy has not been adequately evaluated in acute hepatitis C virus (HCV) infection. This randomized trial assessed the efficacy, safety, and timing of pegylated interferon alfa-2b for treatment of acute hepatitis C...
  101. ncbi High-risk HLA allele mismatch combinations responsible for severe acute graft-versus-host disease and implication for its molecular mechanism
    Takakazu Kawase
    Division of Immunology, Aichi Cancer Center, Nagoya, Japan
    Blood 110:2235-41. 2007
    ..Furthermore, the identification of high-risk mismatch, that is, nonpermissive mismatch, would be beneficial for the selection of a suitable donor...

Research Grants62

  1. Determining Molecular Mechanisms of Chikungunya Virulence and Attenuation
    KATHERINE D RYMAN; Fiscal Year: 2010
    ..of virus/host interaction and thereby facilitate the subsequent design of therapeutics for the treatment of acute disease and vaccines for protection...
  2. HIV-1 Inhibition using Tat Peptide Derivatives
    Fatah Kashanchi; Fiscal Year: 2013
    ..the mid-1990s, survival following HIV diagnosis has risen dramatically and HIV infection has evolved from an acute disease process to being managed as a chronic medical condition...
  3. A MOUSE MODEL FOR HUMAN INHERITED DISEASES
    Philip A Wood; Fiscal Year: 2010
    ..the role of genetic background and dietary macronutrient (fat, carbohydrates) influences on development of acute disease in homozygous LCAD deficient mice...
  4. MONOKINE GENE EXPRESSION/REGULATION IN LUNG INJURY
    STEVEN LYNN KUNKEL; Fiscal Year: 2013
    ..While sepsis has often been viewed as a deadly acute disease, it also has insidious long-term consequences...
  5. Development of the Cotton Rat Model of Rhinovirus Infection and Disease
    JORGE C BLANCO; Fiscal Year: 2013
    ..by (a) defining the kinetics of HRV16 infection;(b) selecting clinical parameters that can be use to follow acute disease;(c) describing the HRV16-induced pathology of the upper and lower respiratory tract;and (d) defining the ..
  6. Environmental Health Specialist Network
    RICHARD NORMAN DANILA; Fiscal Year: 2013
    ..health specialists from the MDH Division of Environmental Health and epidemiologists from the MDH Acute Disease Investigation and Control Section will comprise the MDH EHS-Net team and will work closely together to conduct ..
  7. Functional Characterization of Coxiella burnetii Dot/Icm Substrates
    Daniel E Voth; Fiscal Year: 2010
    ..burnetii is a CDC Category B select agent and causes the zoonosis human Q fever, a debilitating acute disease that also presents as chronic endocarditis. Characterization of C...
  8. The AP2 factors required for Toxoplasma replication
    Michael W White; Fiscal Year: 2013
    ..These studies will provide fundamental knowledge of a new set of mechanisms required to produce parasite replication that is relevant to acute disease caused by the growth of Toxoplasma in the immunocompromised human host.
  9. Characterizing the role of type IV-secreted CpeD and CpeE in Coxiella burnetii in
    Daniel E Voth; Fiscal Year: 2013
    ..Three of these proteins are conserved in all isolates and three are specific to the QpH1 plasmid from a human acute disease isolate...
  10. A "radical" approach to tuberculosis infection
    Deborah T Hung; Fiscal Year: 2013
    ..Complicating its management are its diverse manifestations, ranging from acute disease to latent infection...
  11. CaMKII in neuronal signaling and degeneration
    Andy Hudmon; Fiscal Year: 2013
    ..Excessive glutamate release accompanies acute disease states (e.g...
  12. Immunosuppression and Innate Immunity Control by Morbilliviruses
    Roberto B Cattaneo; Fiscal Year: 2013
    ..MV and canine distemper virus (CDV) infect immune cells and replicate to high levels before causing acute disease. The extent of viral replication documented in immune cells implies that it can directly cause ..
  13. Novel nucleosome composition and modifications in protozoal parasite Toxoplasma g
    Sergio Oscar Angel; Fiscal Year: 2012
    ..In humans, acute disease is caused by rapidly growing 'tachyzoites'while chronic diseases is caused by latent '..
  14. High sensitivity discovery of cis-regulatory modules
    Saurabh Sinha; Fiscal Year: 2012
    ..phenotypic variation, drivers of evolutionary change, and causes of birth defects as well as chronic and acute disease. Identifying CRMs genome-wide is an important first step on the way to comprehending both normal and ..
  15. Prefrontal Modulation of Cognitive Deficits
    MEGAN MARIE MARTIN ST PETERS; Fiscal Year: 2010
    ..2007), consistent with a hyper-responsive mesolimbic DA system observed during acute disease periods in schizophrenia (Laruelle, 2000;Laruelle et al., 1999)...
  16. The role of cigarette smoke toxin and alcohol in pancreatitis
    Edwin C Thrower; Fiscal Year: 2013
    ..Since many believe that chronic alcoholic pancreatitis is the result of multiple subclinical bouts of acute disease, it is possible that the mechanisms identified here would be common to both acute and chronic disease forms...
  17. Regulation of pathogen-specific T cell immunity by adenosine generation
    Dirk Homann; Fiscal Year: 2013
    ..Following resolution of acute disease or successful vaccination regimens, specific CD8+ effector T cells (CD8+TE) are subject to a gradual ..
  18. The role of TRAIL in immune control of cytomegalovirus
    CHRISTOPHER A BENEDICT; Fiscal Year: 2013
    ..subclinical despite inducing a robust immune response and establishing lifelong persistence/latency, causing acute disease only if host defenses are immature or compromised...
  19. T-bet and the Th1/Th17 balance in Acute HIV infection
    LAURIE HOLLIS GLIMCHER; Fiscal Year: 2011
    ..increase IL-2 production necessary for functional CD8+ cell T responses 4) increase numbers of polyfunctional T cells and 5) will ameliorate acute disease in two different mouse models of AIDS: MAIDS and the BLT humanized mouse model.
  20. Linking Triazole Resistance and Fitness in Aspergillus fumigatus
    David S Perlin; Fiscal Year: 2013
    ..to important clinical respiratory specimens from patients with chronic disease, including cystic fibrosis, and acute disease. This work will greatly advance our understanding of the importance of triazole resistance in the management ..
  21. MICRONEME FUNCTION IN TOXOPLASMA
    VERNON BRUCE CARRUTHERS; Fiscal Year: 2013
    ..We recently showed that T. gondii rapid egress and fatal acute disease both depend on the timely secretion of a pore-forming protein, TgPLP1...
  22. The role of TRAIL in immune control of cytomegalovirus
    CHRISTOPHER A BENEDICT; Fiscal Year: 2012
    ..despite inducing a robust immune response and establishing lifelong persistence/latency, and causes acute disease only if host defenses are immature or compromised...
  23. Stimulation of Mitochondrial Biogenesis with 5-HT Receptor Agonists
    Jennifer Blakely; Fiscal Year: 2013
    ..This work seeks to examine the usefulness of 5-HT2 receptor agonists in the treatment of this acute disease state.
  24. Growth factor mimicry in Trypanosoma cruzi invasion of the heart
    MERCIO A PEREIRAPERRIN; Fiscal Year: 2013
    ..have or will develop cardiomyopathy years or decades after the parasite first invades cardiomyocytes during acute disease. The goal of this proposal is to decipher the molecular basis for T...
  25. Complementary Injectable Tungsten Contrast for Dual Contrast Dual Energy CT
    Benjamin M Yeh; Fiscal Year: 2013
    ..Currently, CT imaging is among the most clinically utilized and valuable tests, particularly for trauma and acute disease, but remains severely limited by 1) its inability to differentiate between the available contrast materials ..
  26. Process Development on a Schistosomiasis Vaccine, SchistoShield???
    Afzal A Siddiqui; Fiscal Year: 2013
    ..Our candidate vaccine has three protective effects: worm reduction, egg reduction, and protection against acute disease. Funding this application will help our continuing efforts to develop Sm-p80 towards manufacture for future ..
  27. MOP/LAS chimeric vaccine against Lassa fever
    Igor Lukashevich; Fiscal Year: 2007
    ..We will test the hypothesis that the Lassa L RNA segment is associated with fatal acute disease in experimental animals and that the MOP/LAS reassortant virus consisting of the L RNA of Mopeia and the S RNA ..
  28. Trypanosoma cruzi-elicited cardiac hypertrophy
    Christine Petersen; Fiscal Year: 2004
    ..cruzi infected mice and to correlate responses observed in vitro to those produced in the host during acute disease. Information generated from this research will immediately and significantly enhance the current understanding ..
  29. Innate Immune Responses during Toxoplasmosis
    Julio Aliberti; Fiscal Year: 2010
    ..While effective at controlling acute disease, available drugs fail to clear chronic, latent infection with T. gondii...
  30. DEMYELINATING DISEASE: VIRAL AND IMMUNE FUNCTION
    Stephen Stohlman; Fiscal Year: 2007
    ..Thus, rapid T cell infiltration during acute disease is crucial to controlling virus replication in order to limit subsequent immune mediated pathogenesis...
  31. Streptococcal pharyngitis in slum versus non-slum communities in Salvador Brazil
    SARA TARTOF; Fiscal Year: 2007
    unreadable] DESCRIPTION (provided by applicant): Streptococcal pharyngitis is the acute disease that precedes the chronic disease process of rheumatic heart disease (RHD)...
  32. BIOSENSOR FOR DIAGNOSIS OF PERIODONTAL DISEASES
    Bill Colston; Fiscal Year: 2001
    ..and have implicated polymorphonuclear leukocytes as being an important, if not the major, contributor to the acute disease process...
  33. EMERGENCE OF HUMAN PATHOGENS IN THE GENUS BORDETELLA
    Eric Harvill; Fiscal Year: 2007
    ..pertussis and B. parapertussis. Both organisms are highly contagious, cause acute disease with high pathology and display strong resistance to antibodymediated clearance, characteristics not observed ..
  34. Attenuation of Axonal Damage and Neuronal Death in EAE
    Naren L Banik; Fiscal Year: 2010
    ..cell activation, axonal degeneration, and apoptotic proteins are increased in EAE spinal cord at the onset of acute disease. Additionally, treatment with the calpain inhibitor SJA6017 (SJA) reduced immune cell activation and ..
  35. Dental Plaque Accumulation as a Risk Factor for CHD
    Michael Kowolik; Fiscal Year: 2005
    ..Oral disease is increasingly implicated in this capacity. This study will employ an acute disease model to determine whether dental plaque accumulation and the resultant gingivitis have systemic consequences ..
  36. The Effects of Interferons on Anthrax Toxicity
    Andrew Larner; Fiscal Year: 2005
    Anthrax is an acute disease caused by the gram-positive bacterium Bacillus anthracis...
  37. Animal models to design & evaluate improved VZV vaccines
    WAYNE GRAY; Fiscal Year: 2007
    ..Following resolution of the acute disease, VZV establishes latent infection in neural ganglia...
  38. IMMUNE RESPONSE IN ACUTE AND CHRONIC CHAGAS'S DISEASE
    Wesley Van Voorhis; Fiscal Year: 1993
    ..cruzi establishes a chronic infection, how immunopathogenesis contributes to acute disease manifestations, and how acute infection leads to loss of tolerance and eventual autoimmunity...
  39. Rapid, accurate diagnostics for arenaviral infections
    CHARLES FULHORST; Fiscal Year: 2003
    ..Rapid, accurate diagnosis of acute disease caused by these viruses is critical to a timely and appropriate response by public health authorities in the ..
  40. VA NET, COORDINATING AND OPERATIONS RESEARCH CENTER
    John Hamilton; Fiscal Year: 2000
    ..HIV can no longer be considered a uniformly rapidly fatal, acute disease. The approach to research on HIV as a chronic disease is different than previous HIV research that has ..
  41. Role of motility in Borrelia burgdorferi pathogenesis
    Chunhao Li; Fiscal Year: 2006
    ..In the United States, one of the major manifestations of the acute disease is Lyme arthritis...
  42. Stem Cells for Neonatal Hypoxic-Ischemic Brain Injury
    James Carroll; Fiscal Year: 2006
    ..Much promise has been shown using stem cells in acute disease models such as stroke or hypoxic injury to the brain, and as well to chronic degenerative diseases such as ..
  43. MECHANISMS OF NEUROGENIC INFLAMMATORY RESPONSE
    Jen Wei; Fiscal Year: 1993
    ..Because mast cell degranulation and vasomotor modulation are linked to chronic and acute disease, the results of these experiments will be of clinical, as well as, theoretical interest...
  44. PERSISTENT VIRUS ON CENTRAL NERVOUS SYSTEM IMMUNITY
    Stephen Stohlman; Fiscal Year: 2004
    DESCRIPTION (from applicant's abstract): Human immunodeficiency virus-1 (HIV) infects the CNS during acute disease. However, the absence of an effective sterilizing immunity results in persistent CNS infection which may contribute to ..
  45. MOLECULAR BASIS OF TYZZER'S DISEASE IN RESEARCH ANIMALS
    Lela Riley; Fiscal Year: 1993
    ..b>Acute disease appears to be rare in natural infections, but seemingly healthy animals can harbor a latent form of infection ..
  46. Novel cell-culture derived split influenza vaccine
    JONATHAN SEALS; Fiscal Year: 2004
    Influenza viruses cause annual epidemics of acute disease and periodic pandemics of serious disease...
  47. Genetic Dissection of Tumor Progression in NF-1 AML
    Margaret Wallace; Fiscal Year: 2005
    ..identical reconstituted mice developed a JMML-like disorder, but only a subset went on to develop more acute disease. This result strongly suggests that additional genetic lesions are responsible for disease progression...
  48. Maturation of established antiviral CD8 T cell memory
    Dirk Homann; Fiscal Year: 2006
    ..Following resolution of acute disease, specific CD8+ effector T cells are subject to a process that combines the selection of defined effector T ..
  49. STATISTICAL ANALYSIS OF MULTIPLE EVENT TIME DATA
    David Oakes; Fiscal Year: 1999
    ..Examples of such data include time to tumor detection, time from remission to relapse into an acute disease phase, and times to discontinuation of experimental medications...
  50. NATURAL HISTORY STUDIES: GBS AND PNEUMOCOCCAL INFECTION
    Barry Gray; Fiscal Year: 1992
    ..functions other than opsonization will focus upon the activation of platelets and neutrophils in vitro and in acute disease. The immunochemistry of GBS polysaccharides will be studied in Project 2...
  51. AFRICAN AMERICANS WITH AIDS--THE CAREGIVING EXPERIENCE
    Andrea Sankar; Fiscal Year: 1999
    DESCRIPTION (Applicant's Abstract): The conceptualization and treatment of HIV is changing from an acute disease requiring hospital says, to a chronic illness which allows, in the absence of acute exacerbations, the PWH to live in the ..
  52. AIDS CAREGIVING--ROLE OF INFORMAL AND FORMAL SUPPORTS
    Karen Fredriksen Goldsen; Fiscal Year: 2001
    ..As AIDS changes from an acute disease to a chronic illness, it places increased responsibility on personal support systems to provide long-term ..
  53. Treatment of HCMV in transplant vascular scelrosis
    James Hicks; Fiscal Year: 2002
    ..S. population. (H)CMV infection does not cause noticeable acute disease in healthy individuals, but is implicated in several forms of chronic vascular disease...
  54. Computational tests of urinary tract infection mechanism
    SWAINE CHEN; Fiscal Year: 2007
    ..coli). Traditionally, recurrent UTI was thought to be an acute disease resulting from repeated inoculation of bacteria into the urinary tract...
  55. IMMUNE CELL ACTIVATION BY A UNIQUE LENTIVIRUS NEF ALLELE
    LINDA WHETTER; Fiscal Year: 2001
    ..The experimental aspects of this project focuses on SIVsmmPBj14, which causes severe acute disease in vivo, and efficiently triggers the proliferation of resting simian lymphocytes in vitro...
  56. Pathogen-Host Standoff: Persistent and Latent Infection
    Edward Mocarski; Fiscal Year: 2005
    ..Although infectious disease agents cause acute disease, many cause both acute and chronic infections...
  57. Pathogen-Host Standoff: Persistent and Latent Infection
    Joanne Flynn; Fiscal Year: 2004
    Infectious diseases are the major cause of morbidity and mortality worldwide. Although many infections cause acute disease, other pathogens, can cause acute and chronic infections...
  58. Role of cruzain in T. cruzi and macrophage interactions
    PNG LOKE; Fiscal Year: 2007
    ..This clone, Cai-KR is non-pathogenic in wildtype mice, but can cause acute disease in RAG1-/- mice...
  59. Lentiviral Diseases: EIAV Pathogenesis
    SUSAN LYNNE PAYNE; Fiscal Year: 2010
    ..viruses and recombinant SU proteins, (iii) Test sub-regions of SU for their contribution to the development of acute disease in a Shetland pony model. AIM 2...
  60. Treating Anxiety in Public Sector Medical Settings
    Peter Roy Byrne; Fiscal Year: 2007
    ..As my skills in this latter area evolve over the course of this award, I hope to be able to mentor them even more effectively in this specific area as well. ..
  61. EVOLUTION OF VIRULENCE OF EQUINE INFECTIOUS ANEMIA VIRUS
    Susan Payne; Fiscal Year: 2002
    ..The EIAV system provides an excellent and tractable experimental model for study of evolutionary change in retroviruses, and for understanding the evolution and determinants of virulence. ..
  62. PROSPECTIVE INVESTIGATION OF PULMONARY EMBOLISM DX-II
    Victor Tapson; Fiscal Year: 2003
    ..abstract_text> ..