sudden death

Summary

Summary: The abrupt cessation of all vital bodily functions, manifested by the permanent loss of total cerebral, respiratory, and cardiovascular functions.

Top Publications

  1. ncbi Risk factors in sudden death in epilepsy (SUDEP): the quest for mechanisms
    Lina Nashef
    Neurology Department, Kings College Hospital, London, UK
    Epilepsia 48:859-71. 2007
  2. ncbi Sudden death in growth hormone-treated children with Prader-Willi syndrome
    Guy Van Vliet
    Departments of Pediatrics and Pathology, Sainte Justine Hospital and Research Center, University of Montreal, Quebec, Canada
    J Pediatr 144:129-31. 2004
  3. ncbi Tissue and organ donation for research in forensic pathology: the MRC Sudden Death Brain and Tissue Bank
    T Millar
    Neuropathology Unit, University of Edinburgh, Alexander Donald Building, Western General Hospital, Edinburgh, EH4 2XU, UK
    J Pathol 213:369-75. 2007
  4. pmc Anesthetic- and heat-induced sudden death in calsequestrin-1-knockout mice
    Marco Dainese
    Ce S I Department of Basic and Applied Medical Sciences, Interuniversity Institute of Myology, University G D Annunzio, I 66013 Chieti, Italy
    FASEB J 23:1710-20. 2009
  5. pmc Cardiac-myocyte-specific excision of the vinculin gene disrupts cellular junctions, causing sudden death or dilated cardiomyopathy
    Alice E Zemljic-Harpf
    Department of Medicine, UCSD School of Medicine, La Jolla, California, USA
    Mol Cell Biol 27:7522-37. 2007
  6. ncbi Sudden death in young adults: a 25-year review of autopsies in military recruits
    Robert E Eckart
    Brooke Army Medical Center, San Antonio, Texas, USA
    Ann Intern Med 141:829-34. 2004
  7. pmc RyR1 S-nitrosylation underlies environmental heat stroke and sudden death in Y522S RyR1 knockin mice
    William J Durham
    Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, TX 77030, USA
    Cell 133:53-65. 2008
  8. pmc Mice with cardiac-restricted angiotensin-converting enzyme (ACE) have atrial enlargement, cardiac arrhythmia, and sudden death
    Hong D Xiao
    Department of Pathology and Laboratory Medicine, Emory University, Atlanta, Georgia, USA
    Am J Pathol 165:1019-32. 2004
  9. ncbi The CETP TaqIB polymorphism is associated with the risk of sudden death in type 2 diabetic patients
    Isabelle Porchay-Baldérelli
    Institut National de la Sante et de la Recherche Medicale, U695, Genetic Determinants for Type 2 Diabetes and Its Vascular Complications, Paris, France
    Diabetes Care 30:2863-7. 2007
  10. ncbi Cocaine-induced channelopathies: emerging evidence on the multiple mechanisms of sudden death
    Jerry L Bauman
    University of Illinois at Chicago, Department of Pharmacy Practice, Section of Cardiology 60612, USA
    J Cardiovasc Pharmacol Ther 7:195-202. 2002

Detail Information

Publications268 found, 100 shown here

  1. ncbi Risk factors in sudden death in epilepsy (SUDEP): the quest for mechanisms
    Lina Nashef
    Neurology Department, Kings College Hospital, London, UK
    Epilepsia 48:859-71. 2007
    ....
  2. ncbi Sudden death in growth hormone-treated children with Prader-Willi syndrome
    Guy Van Vliet
    Departments of Pediatrics and Pathology, Sainte Justine Hospital and Research Center, University of Montreal, Quebec, Canada
    J Pediatr 144:129-31. 2004
    ..Autopsy showed multifocal bronchopneumonia. This case and two others recently published suggest that growth hormone may be associated with obstructive apnea, respiratory infection, and sudden death in this condition.
  3. ncbi Tissue and organ donation for research in forensic pathology: the MRC Sudden Death Brain and Tissue Bank
    T Millar
    Neuropathology Unit, University of Edinburgh, Alexander Donald Building, Western General Hospital, Edinburgh, EH4 2XU, UK
    J Pathol 213:369-75. 2007
    ..The potential for acquisition of normal CNS and non-CNS tissues and of various hard-to-get CNS disorders suggests that efforts to access the forensic post mortem service for research material are eminently worthwhile...
  4. pmc Anesthetic- and heat-induced sudden death in calsequestrin-1-knockout mice
    Marco Dainese
    Ce S I Department of Basic and Applied Medical Sciences, Interuniversity Institute of Myology, University G D Annunzio, I 66013 Chieti, Italy
    FASEB J 23:1710-20. 2009
    ..that CASQ1-null mice exhibit increased spontaneous mortality and susceptibility to heat- and anesthetic-induced sudden death. Exposure of CASQ1-null mice to either 2% halothane or heat stress triggers lethal episodes characterized by ..
  5. pmc Cardiac-myocyte-specific excision of the vinculin gene disrupts cellular junctions, causing sudden death or dilated cardiomyopathy
    Alice E Zemljic-Harpf
    Department of Medicine, UCSD School of Medicine, La Jolla, California, USA
    Mol Cell Biol 27:7522-37. 2007
    ..b>Sudden death was found in 49% of the knockout (cVclKO) mice younger than 3 months of age despite preservation of contractile ..
  6. ncbi Sudden death in young adults: a 25-year review of autopsies in military recruits
    Robert E Eckart
    Brooke Army Medical Center, San Antonio, Texas, USA
    Ann Intern Med 141:829-34. 2004
    b>Sudden death among military recruits is a rare but devastating occurrence...
  7. pmc RyR1 S-nitrosylation underlies environmental heat stroke and sudden death in Y522S RyR1 knockin mice
    William J Durham
    Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, TX 77030, USA
    Cell 133:53-65. 2008
    ..We propose a feed-forward cyclic mechanism that increases the temperature sensitivity of RyR1 activation and underlies heat stroke and sudden death. The cycle eventually produces a myopathy with damaged mitochondria.
  8. pmc Mice with cardiac-restricted angiotensin-converting enzyme (ACE) have atrial enlargement, cardiac arrhythmia, and sudden death
    Hong D Xiao
    Department of Pathology and Laboratory Medicine, Emory University, Atlanta, Georgia, USA
    Am J Pathol 165:1019-32. 2004
    ..Despite near normal blood pressure and a normal renal function, ACE 8/8 mice have a high incidence of sudden death. Both histological analysis and in vivo catheterization of the heart showed normal ventricular size and ..
  9. ncbi The CETP TaqIB polymorphism is associated with the risk of sudden death in type 2 diabetic patients
    Isabelle Porchay-Baldérelli
    Institut National de la Sante et de la Recherche Medicale, U695, Genetic Determinants for Type 2 Diabetes and Its Vascular Complications, Paris, France
    Diabetes Care 30:2863-7. 2007
    Type 2 diabetic patients have a high risk of coronary heart disease (CHD) and sudden death. This cardiovascular risk can be partly attributed to low levels of HDL cholesterol...
  10. ncbi Cocaine-induced channelopathies: emerging evidence on the multiple mechanisms of sudden death
    Jerry L Bauman
    University of Illinois at Chicago, Department of Pharmacy Practice, Section of Cardiology 60612, USA
    J Cardiovasc Pharmacol Ther 7:195-202. 2002
    b>Sudden death due to cocaine in the absence of myocardial infarction has been attributed to the precipitation of life-threatening arrhythmias not unlike that due to antiarrhythmic drugs...
  11. ncbi Sudden death among patients with acute promyelocytic leukemia treated with arsenic trioxide
    P Westervelt
    Division of Bone Marrow Transplantation and Stem Cell Biology, and the Division of Molecular Oncology, Washington University School of Medicine, St Louis, MO 63110, USA
    Blood 98:266-71. 2001
    ..Autopsies obtained on 2 of these failed to identify a cause of sudden death, despite evidence of pulmonary hemorrhage in one...
  12. ncbi Sudden death due to subarachnoid bleeding from ecchordosis physaliphora
    T Fracasso
    Institute of Legal Medicine, University of Munster, Röntgenstrasse 23, 48149 Munster, Germany
    Int J Legal Med 122:225-7. 2008
    ..Further histological and immunohistochemical investigations allowed the diagnosis of EP...
  13. pmc Expression of protein kinase C beta in the heart causes hypertrophy in adult mice and sudden death in neonates
    J C Bowman
    Department of Medicine, Albert Einstein College of Medicine, New York, NY 10461, USA
    J Clin Invest 100:2189-95. 1997
    ..ventricular hypertrophy associated with impaired diastolic relaxation, whereas expression in newborns caused sudden death associated with marked abnormalities in the regulation of intracellular calcium...
  14. ncbi Sudden death in Prader-Willi syndrome: brief review of five additional cases. Concerning the article by U. Eiholzer et al.: Deaths in children with Prader-Willi syndrome. A contribution to the debate about the safety of growth hormone treatment in childre
    Bert Bakker
    Horm Res 67:203-4. 2007
  15. ncbi Prolonged QTc interval and risks of total and cardiovascular mortality and sudden death in the general population: a review and qualitative overview of the prospective cohort studies
    Alicia Montanez
    Division of Cardiovascular Research, Mount Sinai Medical Center and Miami Heart Institute, Miami Beach, FL, USA
    Arch Intern Med 164:943-8. 2004
    ..interval may increase total and cardiovascular mortality due to life-threatening ventricular arrhythmias and sudden death. Nonetheless, whether modest prolongation of the QTc interval in the general population has clinical importance ..
  16. ncbi Sudden death due to cerebrotendinous xanthomatosis confirmed by mutation analysis
    J P Sperhake
    Institut fur Rechtsmedizin, Universitat Hamburg, Germany
    Int J Legal Med 113:110-3. 2000
    A case of sudden death of a 52-year-old mentally retarded Caucasian male is described where the rectal temperature was 43.4 degrees C 3 h postmortem...
  17. ncbi Accuracy of magnetic resonance imaging in determining cause of sudden death in adults: comparison with conventional autopsy
    I S D Roberts
    Department of Cellular Pathology, Oxford Radcliffe Hospitals, UK
    Histopathology 42:424-30. 2003
    To determine the accuracy and define the limitations of post mortem magnetic resonance imaging (MRI) in determining the cause of sudden death in adults.
  18. ncbi Sudden death and use of stimulant medications in youths
    Madelyn S Gould
    Division of Child and Adolescent Psychiatry, New York State Psychiatric Institute, 1051 Riverside Dr, New York, NY 10032
    Am J Psychiatry 166:992-1001. 2009
    ..The authors sought to determine whether a significant association exists between the use of stimulants and the rare event of sudden unexplained death in children and adolescents...
  19. pmc The cardiac sodium channel mutation delQKP 1507-1509 is associated with the expanding phenotypic spectrum of LQT3, conduction disorder, dilated cardiomyopathy, and high incidence of youth sudden death
    Ruiming Shi
    1Department of Paediatrics, First Affiliated Hospital, Cardiovascular Ion Channel Disease Laboratory, Medical College of Xi an Jiaotong University, Xi an, Peoples Republic of China
    Europace 10:1329-35. 2008
    ..We report diverse phenotypic consequences of the delQKP-1507-1509 cardiac sodium channel mutation in three generations of a Chinese family...
  20. ncbi Serotonin transporter gene deficiency is associated with sudden death of newborn mice through activation of TGF-beta1 signalling
    Luigi Michele Pavone
    Department of Biological Structures, Functions and Technologies, University of Naples Federico II, Via F Delpino 1, 80137 Naples, Italy
    J Mol Cell Cardiol 47:691-7. 2009
    ..These data suggest a cardiac phenotype for the sudden death of SERT-KO mice. Histological analysis of heart sections showed that SERT-KO mice develop cardiac fibrosis...
  21. ncbi Acute obstructive hydrocephalus and sudden death in children
    S Shemie
    Department of Critical Care Medicine, Hospital for Sick Children, University of Toronto, Ontario, Canada
    Ann Emerg Med 29:524-8. 1997
    b>Sudden death from obstructive hydrocephalus related to intracranial neoplasms has rarely been reported in the pediatric literature...
  22. ncbi Sickle cell lung disease and sudden death: a retrospective/prospective study of 21 autopsy cases and literature review
    Jason K Graham
    Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia, USA
    Am J Forensic Med Pathol 28:168-72. 2007
    b>Sudden death in the setting of sickle cell lung disease (SCLD), is periodically seen in the practice of medical examiners...
  23. ncbi Characteristics of sudden death in hemodialysis patients
    A J Bleyer
    Section on Nephrology, Department of Internal Medicine, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Kidney Int 69:2268-73. 2006
    ..We hypothesized that sudden death occurrences in HD patients are related to the timing of HD, and that they occur more frequently in the 12 h ..
  24. ncbi Acute metabolic decompensation and sudden death in Barth syndrome: report of a family and a literature review
    Ting Yu Yen
    Department of Pediatrics, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan
    Eur J Pediatr 167:941-4. 2008
    ..In conclusion, mutations in taffazin impair mitochondrial respiratory chain complexes, which may results in the acute metabolic decompensation and sudden death; cardiac transplantation is the only possibility at the present time.
  25. ncbi Anti-HERG activity and the risk of drug-induced arrhythmias and sudden death
    M L De Bruin
    Department of Pharmacoepidemiology and Pharmacotherapy, Utrecht Institute for Pharmaceutical Sciences UIPS, PO Box 80082, 3508 TB Utrecht, The Netherlands
    Eur Heart J 26:590-7. 2005
    ..resulting from inhibition of HERG potassium channels may lead to serious ventricular arrhythmias and sudden death. We studied the quantitative anti-HERG activity of pro-arrhythmic drugs as a risk factor for this outcome in ..
  26. pmc First report of sudden death due to myocarditis caused by adenovirus serotype 3
    Ann Treacy
    Department of Histopathology, Children s University Hospital, Temple Street, Dublin 1, Ireland
    J Clin Microbiol 48:642-5. 2010
    Myocarditis is a rare cause of sudden death in childhood...
  27. ncbi Heart block, ventricular tachycardia, and sudden death in ACE2 transgenic mice with downregulated connexins
    Mary Donoghue
    Millennium Pharmaceuticals, Inc, Cambridge, MA, USA
    J Mol Cell Cardiol 35:1043-53. 2003
    ..These animals had a high incidence of sudden death that correlated with transgene expression levels...
  28. ncbi Sudden death from fulminant acute cerebellitis
    E I Levy
    Department of Neurosurgery, Children's Hospital of Pittsburgh, PA, USA
    Pediatr Neurosurg 35:24-8. 2001
    ..This disease has been reported to have a variable course. We report a case of sudden death from acute fulminant cerebellitis in a 13-year-old ballet dancer...
  29. ncbi Psychotropic drugs, cardiac arrhythmia, and sudden death
    Harry J Witchel
    Department of Physiology and Cardiovascular Research Laboratories, School of Medical Sciences, University of Bristol, Bristol, United Kingdom
    J Clin Psychopharmacol 23:58-77. 2003
    ..system are associated with cardiac side effects, some of which are linked with reports of arrhythmia and sudden death. Some psychotropic drugs, particularly tricyclic antidepressants (TCAs) and antipsychotic agents, are ..
  30. ncbi Sudden death in Prader-Willi syndrome during growth hormone therapy
    Michele Sacco
    Division of Paediatrics, IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy
    Horm Res 63:29-32. 2005
    ..This case raises the question about the association between sudden death in children with PWS (with or without respiratory problems) and GH therapy, as already suspected in the recent ..
  31. ncbi Profile of sudden death in an adult population (1999-2008)
    M R Downes
    Department of Histopathology, Beaumont Hospital, Beaumont, Dublin 9
    Ir Med J 103:183-4. 2010
    b>Sudden death is the sudden and unexpected death of an individual within 24 hours of symptom onset. The vast majority of these cases are found, at autopsy, to be due to underlying ischaemic cardiac disease...
  32. ncbi Sudden death of an infant with Prader-Willi syndrome--not a unique case?
    Yves Nordmann
    Foundation Growth Puberty Adolescence, Zurich, Switzerland
    Biol Neonate 82:139-41. 2002
    ..We report an infant with PWS and respiratory problems, who suffered sudden death. To our knowledge, this is the first such case...
  33. pmc Lack of mitochondrial trifunctional protein in mice causes neonatal hypoglycemia and sudden death
    J A Ibdah
    Department of Internal Medicine, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
    J Clin Invest 107:1403-9. 2001
    ..Mtpa(-/-) mice suffer neonatal hypoglycemia and sudden death 6-36 hours after birth...
  34. pmc Sudden death, febrile seizures, and hippocampal and temporal lobe maldevelopment in toddlers: a new entity
    Hannah C Kinney
    Department of Pathology Neuropathology, Children s Hospital and Harvard Medical School, Enders Building, Room 1112, 300 Longwood Avenue, Boston, MA, 02115, USA
    Pediatr Dev Pathol 12:455-63. 2009
    ..In a series of 64 toddlers with sudden death, we tested the hypothesis that an SUDC subset is characterized by hippocampal and temporal lobe maldevelopment ..
  35. ncbi Postmortem computed tomography for detecting causes of sudden death in infants and children: retrospective review of cases
    Yuji Oyake
    Department of Pediatrics, Oyake Children s Clinic, 3 7 19 Higashiishikawa, Hitachinaka 312 0052, Japan
    Radiat Med 24:493-502. 2006
    The aim of this study was to investigate the usefulness of postmortem computed tomography (PMCT) in detecting causes of sudden death in infants and children.
  36. ncbi Beta2-adrenergic receptor antagonists protect against ventricular fibrillation: in vivo and in vitro evidence for enhanced sensitivity to beta2-adrenergic stimulation in animals susceptible to sudden death
    G E Billman
    Department of Physiology, Ohio State University, Columbus 43210 1218, USA
    Circulation 96:1914-22. 1997
    ..Because elevated Ca2+ has been implicated in the induction of ventricular fibrillation (VF), it is possible that the activation of these receptors may also provoke malignant arrhythmias...
  37. pmc Causes of sudden death related to sexual activity: results of a medicolegal postmortem study from 2001 to 2005
    Sanghan Lee
    Department of Forensic Medicine, Kyungpook National University, Jung Gu, Daegu, Korea
    J Korean Med Sci 21:995-9. 2006
    Sexual activity (SA), combined with organic heart disease, may cause sudden death (SD). However, the causes of SD related to SA are not known well. The aim of this study was to assess the causes of SD related to SA...
  38. ncbi Occidental beriberi and sudden death
    Alex P Betrosian
    Intensive Care Unit, Hippokration General Hospital, Athens University, Athens, Greece
    Am J Med Sci 327:250-2. 2004
    ..cases (acute cardiovascular beriberi), early treatment with parenteral vitamin B1 is required to prevent the development of low-output state and sudden death. We report a case of occidental beriberi with fatal outcome despite therapy.
  39. ncbi Deficiency of the alpha and beta subunits of pyruvate dehydrogenase in a patient with lactic acidosis and unexpected sudden death
    W Sperl
    Department of Paediatrics, University of Nijmegen, The Netherlands
    Eur J Pediatr 149:487-92. 1990
    ..The features of this patient are compared with those of other patients reported in the literature with immunochemically confirmed combined E1 alpha and beta deficiency...
  40. pmc Predicting sudden death in patients with mild to moderate chronic heart failure
    M T Kearney
    Department of Cardiology, King s College, Bessemer Road, London SE5 9PJ, UK
    Heart 90:1137-43. 2004
    ..To explore the relation between non-invasive measures of cardiac function and sudden cardiac death, as well as the development and utility of an index integrating these variables to identify patients at increased risk of this mode of death...
  41. ncbi The 'dead in bed syndrome'- a cause of sudden death in Type 1 diabetes mellitus
    R D Start
    Chesterfield Royal Hospital NHS Foundation Trust, Chesterfield, UK
    Histopathology 51:843-5. 2007
  42. ncbi [Sudden death after 125I brachytherapy in prostate cancer patient: a case report]
    Masaki Kimura
    Departments of Urology, Kitasato University School of Medicine
    Nihon Hinyokika Gakkai Zasshi 96:560-3. 2005
    ..Treatment of prostate cancer with brachytherapy has increased in Japan, and we should establish management manual for sudden death case after 125I brachytherapy.
  43. ncbi The insula and cerebrogenic sudden death
    R T Cheung
    Division of Neurology, Department of Medicine, University of Hong Kong, Queen Mary Hospital, Pokfulam Road, Hong Kong, People s Republic of China
    Arch Neurol 57:1685-8. 2000
    b>Sudden death is an "electrical accident" caused by fatal cardiac arrhythmias...
  44. ncbi 4-Hydroxy-1-(3-pyridyl)-1-butanone-releasing DNA adducts in lung, lower esophagus and cardia of sudden death victims
    Daniela Schlöbe
    Walther Straub Institute, Department of Toxicology, Ludwig Maximilians University, Nussbaumstrasse 26, D 80336 Munich, Germany
    Toxicology 245:154-61. 2008
    ..spectrometry (GC-NICI-MS) to samples of peripheral lung, lower esophagus and cardia from tumor-free sudden death victims (primarily road traffic accidents, suicide and sudden cardiac arrest)...
  45. pmc Maximum potential benefit of implantable defibrillators in preventing sudden death after hospital admission because of heart failure
    Soko Setoguchi
    Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02130, USA
    CMAJ 180:611-6. 2009
    ..However, criteria to identify those who would benefit most from this therapy are lacking. We assessed the maximum potential benefit of preventing sudden death in patients with repeated hospital admissions because of heart failure.
  46. pmc Sudden death in an adult taking methadone: lessons for general practice
    Tom Fahey
    Tayside Centre for General Practice, University of Dundee, Kirsty Semple Way, Dundee DD2 4AD
    Br J Gen Pract 53:471-2. 2003
  47. ncbi Sagittal abdominal diameter and risk of sudden death in asymptomatic middle-aged men: the Paris Prospective Study I
    J P Empana
    INSERM Avenir U258, Epidemiology of Sudden Death in the Population, Hopital Paul Brousse, 16 Avenue Paul Vaillant Couturier, 94807 Villejuif, France
    Circulation 110:2781-5. 2004
    Abdominal (visceral) and overall obesity are both related to coronary heart disease mortality risk; however, the relative contribution of these 2 components of fat deposit in the etiology of sudden death is unknown.
  48. ncbi Depletion of medullary serotonergic neurons in patients with multiple system atrophy who succumbed to sudden death
    Mari Tada
    Department of Pathology, Brain Research Institute, University of Niigata, Niigata, Japan
    Brain 132:1810-9. 2009
    ..The leading cause of death in MSA is sudden death. We have shown that the early development of autonomic failure is an independent risk factor for sudden death...
  49. ncbi Sudden death due to giant cell coronary arteritis
    B Karger
    Institute of Legal Medicine, University of Munster, Röntgenstrasse 23, 48149 Munster, Germany
    Int J Legal Med 120:377-9. 2006
    ..The findings were characteristic for giant cell arteritis, the equivalent of temporal Horton arteritis, but isolated involvement of the coronary arteries is exceptional...
  50. pmc Sickle cell trait and sudden death--bringing it home
    Bruce L Mitchell
    J Natl Med Assoc 99:300-5. 2007
    Sickle cell trait continues to be the leading cause of sudden death for young African Americans in military basic training and civilian organized sports...
  51. ncbi Why do individuals with anorexia die? A case of sudden death
    Talia Derman
    Department of Psychiatry, University of the Witwatersrand, Johannesburg, South Africa
    Int J Eat Disord 39:260-2. 2006
    ..The mechanism of death in anorexia nervosa (AN) is unclear...
  52. ncbi Sudden death with circumferential subepicardial fibrofatty replacement: left-sided arrhythmogenic ventricular cardiomyopathy
    Shannon M Mackey-Bojack
    Jesse E Edwards Registry of Cardiovascular Disease, John Nasseff Heart Hospital, Saint Paul, MN 55102, USA
    Am J Forensic Med Pathol 30:209-14. 2009
    ..Four of the 5 cases had siblings with either sudden death or cardiac symptoms...
  53. ncbi An autopsy case of sudden death due to acute gastric dilatation without rupture
    Satoshi Watanabe
    Department of Legal Medicine and of Pharmacy and Pharmacology, Asahikawa Medical College, Midorigaoka Higashi 2 1 1 1, Asahikawa 078 8510, Japan
    Forensic Sci Int 180:e6-e10. 2008
    ..We conclude that the cause of death was acute circulatory failure from hypovolemic shock that occurred following compression of the inferior vena cava and superior mesenteric vein, and by loss of circulatory volume to the third space...
  54. ncbi Frequency of nocturnal sudden death in patients with multiple system atrophy
    T Shimohata
    Dept of Neurology, Brain Research Institute, Niigata University, 1 757 Asahi machi dori Niigata, Niigata 951 8585, Japan
    J Neurol 255:1483-5. 2008
    b>Sudden death has been reported in patients with multiple system atrophy (MSA), although the frequency of this event has not been well delineated. We investigated the frequency and potential causes of sudden death in patients with MSA...
  55. pmc COX-2 gene promoter polymorphism and coronary artery disease in middle-aged men: the Helsinki sudden death study
    Kati H Huuskonen
    Department of Medical Biochemistry, Medical School, University of Tampere, 33104 Tampere, Finland
    Mediators Inflamm 2008:289453. 2008
    ..The Helsinki sudden death study autopsy material (n = 300) comprised of Finnish men who died suddenly...
  56. ncbi Methamphetamine-related sudden death with a concentration which was of a 'toxic level'
    Hiromasa Inoue
    Department of Forensic Pathology and Sciences, Graduate School of Medical Sciences, Kyushu University, Higashi ku, Fukuoka, Japan
    Leg Med (Tokyo) 8:150-5. 2006
    ..Additionally, the mechanism of methamphetamine-related death needs to be more fully studied to enable an appropriate diagnosis to be made easily...
  57. ncbi Three unusual neuropathologic-related causes of sudden death
    Dennis J Chute
    Dutchess County Medical Examiner s Office, 387 Main Street, Poughkeepsie, NY 12601, USA
    J Forensic Sci 53:734-8. 2008
    We discuss the autopsy findings of three medico-legal cases of sudden death associated with uncommon neuropathologic findings of which the general forensic pathologist may not be familiar...
  58. ncbi Antiphospholipid antibody syndrome leading to massive pulmonary embolism and sudden death
    Fuat Gundogdu
    Department of Cardiology, Medicine Faculty of Atatürk University, Erzurum, Turkey
    Turk Kardiyol Dern Ars 36:467-9. 2008
    ..A diagnosis of massive pulmonary embolism was considered. During preparation for emergency operation, the patient developed cardiovascular collapse, which did not respond to cardiopulmonary resuscitation...
  59. ncbi Megaesophagus and possible mechanisms of sudden death
    Sarah Schalinski
    Institute of Legal Medicine and Forensic Sciences, Charite Universitatsmedizin Berlin, Turmstr 21 Haus L, 10559, Berlin, Germany
    J Forensic Sci 54:216-9. 2009
    ..Megaesophagus may, therefore, be a significant finding at autopsy that may either be a primary cause of unexpected death or else may exacerbate or compound the effects of pre-existing underlying disease...
  60. ncbi Meta-analysis of effect of statin treatment on risk of sudden death
    Giacomo Levantesi
    Consorzio Mario Negri Sud, Santa Maria Imbaro, Chieti, Italy
    Am J Cardiol 100:1644-50. 2007
    ..In subgroup analysis, the benefit of statins was independent from the main characteristics of the studies and changes in patient lipid levels during the study. In conclusion, our results suggest that statins decrease the risk of SCD...
  61. ncbi Cardiac findings in an individual with neurofibromatosis 1 and sudden death
    S J Hamilton
    Department of Medical Genetics, University of British Columbia and Children's and Women's Health Centre of British Columbia, Vancouver, British Columbia, Canada
    Am J Med Genet 100:95-9. 2001
    ..We report the sudden death of a young man with NF1...
  62. pmc Hypertension, cardiac hypertrophy, and sudden death in mice lacking natriuretic peptide receptor A
    P M Oliver
    Department of Pathology, University of North Carolina, 710 Brinkhous Bullitt Building, Chapel Hill, NC 27599 7525, USA
    Proc Natl Acad Sci U S A 94:14730-5. 1997
    ..Nevertheless, sudden death, with morphologic evidence indicative in some animals of congestive heart failure and in others of aortic ..
  63. ncbi Sudden death after radiofrequency ablation of the atrioventricular node in patients with atrial fibrillation
    Cevher Ozcan
    Division of Cardiovascular Diseases and Internal Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Am Coll Cardiol 40:105-10. 2002
    We evaluated the incidence and predictors of sudden death after atrioventricular (AV) node ablation and pacemaker implantation.
  64. ncbi Is right coronary artery hypoplasia and sudden death an underdiagnosed association?
    Regula Wick
    Forensic Science SA, University of Adelaide, Adelaide, Australia
    Am J Forensic Med Pathol 28:128-30. 2007
    ....
  65. ncbi Hypothesis about the physiopathology of acute deterioration and sudden death caused by colloid cysts of the third ventricle
    Abderrahmane Hamlat
    Department of Neurosurgery, CHRU Pontchaillou, Rue Henry Le Guilloux, 35000 Rennes, Cedex 2, France
    Med Hypotheses 63:1014-7. 2004
    In this paper, the authors review the mechanisms of acute deterioration and sudden death caused by colloid cysts (CCs)...
  66. ncbi Sudden death associated with intravenous injection of toad extract
    Chris Kostakis
    Forensic Science SA, Adelaide, Australia
    Forensic Sci Int 188:e1-5. 2009
    ..It also shows the difficulties that may be associated with attempting to identify low levels of organic toxins in postmortem specimens necessitating a targeted screening approach guided by information obtained at the death scene...
  67. ncbi Atrial fibrillation during acute myocardial infarction: association with all-cause mortality and sudden death after 7-year of follow-up
    G Berton
    Department of Cardiology, Conegliano General Hospital, Conegliano, Italy
    Int J Clin Pract 63:712-21. 2009
    ..The purpose of the present study was to investigate the relationship between presence of AF/FL and mortality in patients with AMI and to report on predictors of AF/FL...
  68. ncbi Changes in adiponectin and the risk of sudden death, stroke, myocardial infarction, and mortality in hemodialysis patients
    Christiane Drechsler
    Division of Nephrology, Department of Medicine, University Hospital Wurzburg, Josef Schneider Strasse 2, Würzburg D 97080, Germany
    Kidney Int 76:567-75. 2009
    ..of cardiovascular events observed with high adiponectin levels at baseline was associated with high risks of sudden death and stroke but not of myocardial infarction...
  69. ncbi Sudden death caused by dissecting thoracic aortic aneurysm in a patient with autosomal dominant polycystic kidney disease
    Chien Chang Lee
    Department of Emergency Medicine, National Taiwan University Hospital and College of Medicine, National Taiwan University, Taipei 100, Taiwan
    Resuscitation 63:93-6. 2004
    ..In addition, the histological finding indicates the aetiological role of a collagen defect in addition to chronic hypertension in the pathogenesis of aortic dissection in ADPKD patients...
  70. ncbi Adult sudden death caused by aspiration of chewing gum
    S N Njau
    Department of Forensic Medicine and Toxicology, Aristotle University of Thessaloniki, Thessaloniki 54124, Greece
    Forensic Sci Int 139:103-6. 2004
    ..Blood and urine samples were analyzed, for alcohol and drug use by fluorescence polarization immunoassay (FPIA) on an Abbott AXSYM system. No alcohol or other drugs were detected in blood or urine...
  71. ncbi Sudden death due to a colloid cyst of the third ventricle: report of three cases with a special sign at autopsy
    Serafettin Demirci
    Selcuk University, Meram Medical School, Department of Forensic Medicine, Akyokus Mevkii, 42080 Meram, Konya, Turkey
    Forensic Sci Int 189:e33-6. 2009
    ..Three cases of sudden death resulting from colloid cysts of the third ventricle are presented...
  72. ncbi Sudden death in periparturient sheep associated with Clostridium sordellii
    Sandy Clark
    Vet Rec 153:340. 2003
  73. ncbi Cysticercosis of the fourth ventricle causing sudden death: a case report and review of the literature
    Tibor Hortobagyi
    Department of Clinical Neuropathology, King s College Hospital, Denmark Hill, London, SE5 9RS, UK
    Pathol Oncol Res 15:143-6. 2009
    ..well as forensic medical examiners and paediatricians to be aware of neurocysticercosis as a possible cause of sudden death in the presence of normal clinical findings and negative autopsy, especially in patients from Asian, African or ..
  74. ncbi Side of brain infarction and long-term risk of sudden death in patients with symptomatic carotid disease
    Ale Algra
    Department of Neurology and Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
    Stroke 34:2871-5. 2003
    Current publications suggest increased risk of sudden death in experimental animals with acute right insular lesions and in patients with recent right-sided brain infarction, particularly if the insula is involved.
  75. ncbi Sudden death of a patient with pulmonary Langerhans cell histiocytosis
    Hassan Nakhla
    Department of Pathology, State University of New York Upstate Medical University, Syracuse, NY 13210, USA
    Arch Pathol Lab Med 129:798-9. 2005
    We report a case of sudden death due to bilateral pneumothorax in a previously healthy 16-year-old adolescent white girl. She presented with sudden onset of shortness of breath followed by loss of consciousness...
  76. ncbi Use of morphine and 6-monoacetylmorphine in blood for the evaluation of possible risk factors for sudden death in 192 heroin users
    Anna Fugelstad
    Department of Clinical Neurosciences, Karolinska Hospital, Stockholm, Sweden
    Addiction 98:463-70. 2003
    To detect risk factors for sudden death from heroin injection.
  77. pmc Tissue-specific pyruvate dehydrogenase complex deficiency causes cardiac hypertrophy and sudden death of weaned male mice
    Sukhdeep Sidhu
    Department of Biochemistry, University at Buffalo, The State University of New York, Buffalo, NY 14214, USA
    Am J Physiol Heart Circ Physiol 295:H946-H952. 2008
    ..This mouse model demonstrates the importance of glucose oxidation in cardiac energetics and function under basal conditions...
  78. ncbi Unusual sudden death: two case reports of hemorrhage by rupture of varicose veins
    Stephanie Racette
    Laboratoire de Sciences Judiciaires et de Médecine Légale, Montreal, Quebec, Canada
    Am J Forensic Med Pathol 26:294-6. 2005
    ..External hemorrhage is an unusual complication of this common venous pathology. Reported here are 2 cases of severe external hemorrhage resulting from the perforation of a varicose vein...
  79. ncbi Agitated delirium and sudden death
    Gary M Vilke
    Prehosp Emerg Care 6:259; author reply 259-60. 2002
  80. ncbi Congenital central hypoventilation syndrome: PHOX2B genotype determines risk for sudden death
    Jerome O Gronli
    Department of Pediatrics, Rush University Medical Center, Chicago, Illinois 60612, USA
    Pediatr Pulmonol 43:77-86. 2008
    ..We hypothesized that children with CCHS would have a relationship between PHOX2B genotype and two clinically applicable cardiovascular measures of ANSD: duration of longest r-r interval and longest corrected QT interval (QTc)...
  81. ncbi Sudden death due to primary intracranial neoplasms. A forensic autopsy study
    Theodore Vougiouklakis
    Department of Forensic Pathology, Medical School, University of Ioannina, Ioannina, Greece
    Anticancer Res 26:2463-6. 2006
    ..A search for cases of sudden death due to intracranial tumors from a total of 1985 autopsies from the archives of the Department of Forensic ..
  82. ncbi Survey of sudden death from aneurysmal subarachnoid hemorrhage in cadavers referred to Legal Medicine Organization of Tehran, 2001-2005
    Ardeshir Sheikhazadi
    Department of Forensic Medicine, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
    Am J Forensic Med Pathol 30:358-61. 2009
    ..To explain the clinical profile of sudden death from aneurysmal SAH, we examined the epidemiology and clinicopathologic characteristics of patients with ..
  83. ncbi Unexpected autoptic finding in a sudden death: gossypiboma
    Jessica Falleti
    Department of Biomorphological and Functional Science, University Federico II of Naples, Via S Pansini, 5, 80131 Naples, Italy
    Forensic Sci Int 199:e23-6. 2010
    ..and subsequently a trans-luminal migration of the gossypiboma which went through the trachea causing a sudden death of the patient...
  84. ncbi Hepatic hemorrhage, hemocoelom, and sudden death due to Haemoproteus infection in passerine birds: eleven cases
    Taryn A Donovan
    Zoological Society of San Diego, Wildlife Disease Laboratories, San Diego, CA 92101 1635, USA
    J Vet Diagn Invest 20:304-13. 2008
    ..These findings suggest the recognition of a genotype of Haemoproteus that exhibits high levels of host infidelity and causes severe disease in captive birds exotic to North America...
  85. ncbi Sudden death in children due to intracranial mass lesion
    Essam A Elgamal
    Neurosurgery Division 37, College of Medicine and King Khalid University Hospital, PO Box 7805, Riyadh, Saudi Arabia
    Childs Nerv Syst 22:305-9. 2006
    ..We sought to review the presenting symptoms and signs of intracranial mass lesions that led to sudden death to guide clinicians in early identification of these potentially treatable conditions.
  86. ncbi Risk of sudden death in the Williams-Beuren syndrome
    Armin Wessel
    Department of Pediatric Cardiology, Medical School Hannover, Hannover, Germany
    Am J Med Genet A 127:234-7. 2004
    ..The occurrence of sudden death in the WBS is known from several case reports, but information about the risk of sudden death as derived from ..
  87. ncbi Unexplained sudden death, including sudden infant death syndrome (SIDS), in the first and second years of life: case definition and guidelines for collection, analysis, and presentation of immunization safety data
    Gerhard Jorch
    University of Magdeburg, Magdeburg, Germany
    Vaccine 25:5707-16. 2007
  88. ncbi Sudden death due to single coronary artery
    N Turkmen
    Forensic Medicine Department, Uludag University Medical Faculty, Gorukle, Bursa, Turkey
    Singapore Med J 48:573-5. 2007
    Coronary artery anomalies that entail a risk of sudden death are frequently associated with complex cardiac malformations but may occasionally be solitary. A 31-year-old man became ill in the night and lost consciousness...
  89. ncbi Sudden death associated with food and exercise
    Lisa M Flannagan
    Office of the Medical Examiner, Palm Beach County, West Palm Beach, FL 33406, USA
    J Forensic Sci 49:543-5. 2004
    ..An elevated serum tryptase level may be indicative of an allergic reaction, and allergen-specific IgE levels may be used to confirm the particular antigen...
  90. ncbi Serum concentrations of cardiac troponin T in sudden death
    Christian Lycke Ellingsen
    Department of Pathology, Rogaland Central Hospital, Stavanger, Norway
    Am J Forensic Med Pathol 25:213-5. 2004
    Ischemic heart disease is the most common cause of sudden death of natural causes in most western countries...
  91. ncbi Neurocysticercosis presenting as sudden death
    J A Llompart Pou
    Intensive Care Unit, Hospital Universitario Son Dureta, Palma de Mallorca, Spain
    Acta Neurochir (Wien) 147:785-6; discussion 786. 2005
    ..Due to the increasing travel movements of people neurocysticercosis must be considered as a cause of unexplained sudden death.
  92. ncbi Sudden death in competitive athletes
    Fabio Pigozzi
    Laboratory of Sports Medicine, Health Sciences Department, University Institute of Movement Sciences, Piazza Lauro de Bosis 6, 00194 Rome, Italy
    Clin Sports Med 27:153-81, ix. 2008
    b>Sudden death in athletes is an extremely rare event yet no less tragic for its infrequency. Up to 90% of these deaths are due to underlying cardiovascular diseases and therefore categorized as sudden cardiac death (SCD)...
  93. ncbi Sudden death from saccular laryngeal cyst
    Tina K Kastowsky
    Department of Forensic Medicine, Central Sydney Laboratory Service and University of New South Wales, 42 50 Parramatta Road, Glebe, NSW 2037, Australia
    J Forensic Sci 51:1144-6. 2006
    Laryngeal cysts are benign, uncommon lesions of the larynx that have been reported on rare occasions to cause sudden death in infants and adults by acute airways obstruction...
  94. ncbi Sudden death due to dissecting pulmonary artery aneurysm: a case report and review of the literature
    Jason K Graham
    Office of the Chief Medical Examiner, New York, New York 10016, USA
    Am J Forensic Med Pathol 28:342-4. 2007
    ..artery aneurysm and pulmonary artery dissection are rare antemortem diagnoses, most often associated with sudden death. These pathologic entities are strongly associated with chronic pulmonary hypertension due to structural ..
  95. ncbi The probability of sudden death from rupture of intracranial aneurysms: a meta-analysis
    Johnson Huang
    South Western Clinical School, University of New South Wales, Liverpool, New South Wales 2170, Australia
    Neurosurgery 51:1101-5; discussion 1105-7. 2002
    ..To estimate the proportion of patients with aneurysmal subarachnoid hemorrhage (SAH) who die before receiving medical attention...
  96. ncbi Predicting sudden death in the population: the Paris Prospective Study I
    X Jouven
    Service de cardiologie, Hopital Boucicaut, Paris, France
    Circulation 99:1978-83. 1999
    b>Sudden death was found to share the same set of usual risk factors as coronary events and therefore could not be specifically predicted in the population...
  97. ncbi Antipsychotic drugs: prolonged QTc interval, torsade de pointes, and sudden death
    A H Glassman
    Department of Clinical Psychopharmacology, New York State Psychiatric Institute, New York 10032, USA
    Am J Psychiatry 158:1774-82. 2001
    The authors review the mechanisms and establish the risk of torsade de pointes and sudden death with antipsychotic drugs.
  98. ncbi The hepatic lipase gene C-480T polymorphism in the development of early coronary atherosclerosis: the Helsinki Sudden Death Study
    Y M Fan
    Laboratory of Atherosclerosis Genetics, Centre for Laboratory Medicine, Tampere University Hospital and Medical School, University of Tampere, Finland
    Eur J Clin Invest 37:472-7. 2007
    ..We studied the association of HL C-480T polymorphism with the extent of atherosclerosis at vessel-wall level in an autopsy series of middle-aged men...
  99. ncbi The mystery of sudden death: mechanisms for risks
    Claire M Lathers
    Center for Veterinary Medicine, U S Food and Drug Administration, Rockville, MD 20855, USA
    Epilepsy Behav 12:3-24. 2008
    ..Finally, we speculate about potential preventive measures to minimize the risk of both sudden unexpected death in epilepsy and sudden cardiac death...
  100. ncbi Clinical characteristics of unexpected death among young enlisted military personnel: results of a three-decade retrospective surveillance
    Howard Amital
    Israeli Defense Forces Medical Corps, Jerusalem
    Chest 126:528-33. 2004
    ....
  101. ncbi Extraintestinal Escherichia coli isolations from SIDS cases and other cases of sudden death in Victoria, Australia
    J L Pearce
    Department of Agricultural Sciences, Faculty of Science, Technology and Engineering, La Trobe University, Bundoora, Melbourne, Australia
    FEMS Immunol Med Microbiol 25:137-44. 1999
    ..The majority were found to belong to serogroups commonly associated with bacteraemia. These results may indicate that extraintestinal E. coli plays a role in SIDS...

Research Grants71

  1. Community Participation Research of Breastfeeding Disparities in African American
    Tamar Ringel Kulka; Fiscal Year: 2009
    ..episodes, type I and type II diabetes, episodes of infant diarrhea, and incidents of childhood leukemia and sudden death syndrome...
  2. Model of Timothy Syndrome to Screen Drugs with Induced Pluripotent Stem Cells
    Masayuki Yazawa; Fiscal Year: 2013
    ..electrical manifestation of repolarization in ventricular myocytes, is a major cause of cardiac arrhythmia and sudden death. Long QT syndrome (LQTS) can have a genetic basis or be induced by drug exposure or physiological stress...
  3. Model of Timothy Syndrome to Screen Drugs with Induced Pluripotent Stem Cells
    Masayuki Yazawa; Fiscal Year: 2013
    ..electrical manifestation of repolarization in ventricular myocytes, is a major cause of cardiac arrhythmia and sudden death. Long QT syndrome (LQTS) can have a genetic basis or be induced by drug exposure or physiological stress...
  4. Purkinje Origin of Ischemic Ventricular Tachycardia and Fibrillation
    James B Martins; Fiscal Year: 2013
    ..Therapies acting on such pathways used together may prevent sudden death. Mechanisms studied herein could be pursued immediately in clinical trials since readily available drugs, ..
  5. Conditional HSF1 Expression for Ischemic Cardioprotection
    Ivor J Benjamin; Fiscal Year: 2012
    ..left ventricular dysfunction and favorably improve long-term outcomes, such as heart failure and cardiac sudden death. PUBLIC HEALTH RELEVANCE: 7...
  6. Evaluation of obstructive sleep apnea with long range 3D endoscopic FDOCT
    Jun Zhang; Fiscal Year: 2013
    ..increased risk of motor vehicle accidents and the development of cardiovascular diseases with risk for sudden death. The current gold standard diagnostic modality, overnight polysomnography is inconvenient, unable to provide ..
  7. The Impact of Obstructive Sleep Apnea on Non-Alcoholic Fatty Liver Disease
    KATHLEEN ELIZABETH COREY; Fiscal Year: 2013
    ..to suffer from OSA which worsens metabolic disease and increases the risk of cardiovascular disease and sudden death. The study of these conditions and their interactions will lead to new treatment options and improved public ..
  8. Regulation of Cardiac Kv Channel Expression
    Edwin S Levitan; Fiscal Year: 2013
    ..outward current (Ito) channels, which alters heart function and may contribute to arrhythmias that cause sudden death. Experiments in the current funding period showed that Kv4...
  9. BRAINSTEM MATURATION IN THE SUDDEN INFANT DEATH SYNDROME
    HANNAH CHASE KINNEY; Fiscal Year: 2013
    ..g., asphyxia, during a sleep period and leads to sudden death in the critical first year of life when homeostatic systems are not fully mature...
  10. Arrhythmia Mechanisms in Sarcomeric Cardiomyopathies
    Bjorn C Knollmann; Fiscal Year: 2012
    ..Cardiac arrhythmias and sudden death are a major cause for the high mortality of patients with sarcomeric mutations...
  11. Mechanisms of endothelial barrier phenotypes in sickle cell disease
    SOLOMON FIIFI OFORI-ACQUAH; Fiscal Year: 2013
    ..This caused alveolar flooding and sudden death in SCD mice, while control mice with sickle trait survived...
  12. Mitochondrial Protection Within Chronically Ischemic Myocardium
    Edward O McFalls; Fiscal Year: 2010
    ..Revascularization therapies and anti-tachycardia devices are available to prevent sudden death, but among the majority of patients who have received these treatments, the progressive process of cell death ..
  13. Determinants of Disease Expression in Arrhythmogenic Cardiomyopathy
    Jeffrey E Saffitz; Fiscal Year: 2010
    ..the underlying determinants of arrhythmogenesis in ARVC may, therefore, provide new insights into mechanisms of sudden death in more common forms of heart disease. ARVC is a familial disease...
  14. Remodeling of the guinea pig intrinsic cardiac plexus with chronic heart disease
    ELIZABETH MARIE SOUTHERLAND; Fiscal Year: 2013
    ..coupled with increased and heterogeneous sympathetic outflow, increases the risk of cardiac arrhythmias and sudden death. While the progression of cardiac disease affects multiple aspects of cardiac control, it is those changes in ..
  15. Mechanisms of Ventricular Tachycardia in Lipotoxic Cardiomyopathy
    JOHN PEARCE MORROW; Fiscal Year: 2013
    ..cardiomyopathy with impaired systolic function and have abnormal accumulation of intracellular lipids, but sudden death often occurs before HF develops...
  16. Biomarkers of Sudden Death and Progressive Heart Failure
    GORDON FRANK TOMASELLI; Fiscal Year: 2010
    ..of this proposal are two-fold: to enhance understanding of the biological mechanisms that predispose to sudden death and progressive heart failure and to develop a practical gene expression biomarker panel to identify patients ..
  17. Neural Actions of Toluene
    John J Woodward; Fiscal Year: 2013
    ..Research to be carried out in this proposal will provide a detailed analysis of the effects of abused inhalants on neurons within brain areas involved in addiction. ..
  18. Stem cells and the fibroblast/adipocyte lineage in arrhythmogenic cardiomyopathy
    Karen L Vikstrom; Fiscal Year: 2010
    ..Patients suffer very severe arrhythmias and are at great risk of sudden death at a young age...
  19. Angiotensin converting enzyme, angiotensin II, and arrhythmia
    Samuel C Dudley; Fiscal Year: 2010
    ..this, we developed a cardiac-restricted ACE overexpression mouse (ACE 8/8) that showed an increased risk of sudden death in the absence of heart failure or structural heart disease...
  20. Atomic Force Microscopic Studies of Dissecting Aneurysm
    Paul J Boor; Fiscal Year: 2013
    ..those in the teen years to early adulthood, resulting in occlusion of distal vessels, aortic rupture, and sudden death. DAA is associated with several well-described clinical syndromes, but the vast majority of DAAs occur ..
  21. Molecular mechanics of mutant cardiac myosin
    Jeffrey R Moore; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The cardiac hypertrophy, myofibrillar disarray and sudden death caused by familial hypertrophic cardiomyopathy (FHC) results from autosomal dominant mutations in sarcomeric proteins...
  22. IGF::OT::IGF
    Vivian Leung; Fiscal Year: 2013
    ..The most common diagnoses that increase risk for sudden death in the young (SDY) include Dravet Syndrome, other genetic forms of epilepsy, hypertrophic cardiomyopathy, ..
  23. Low energy ventricular defibrillator
    Qun Sha; Fiscal Year: 2012
    ..VF is the most frequent mechanism of sudden death. Implantable cardiac defibrillators (ICDs) have become the standard of care for patients at risk for sudden ..
  24. CaMKII in Sinus Node Physiology and Disease
    Mark E Anderson; Fiscal Year: 2013
    ..SND causes symptomatic bradycardia and sudden death, particularly in patients and animal models with hypertension or heart failure, conditions marked by hyper-..
  25. Genetic and Functional Profiles of Serotonergic Neuron Subtypes
    Rachael D Brust; Fiscal Year: 2013
    ..with high CO2 levels accumulated in a pocket formed by bedding materials;) are considered risk factors for sudden death in these disorders...
  26. Using Genetics For Early Phenotyping &Prevention of Hypertrophic Cardiomyopathy
    Christine E Seidman; Fiscal Year: 2013
    ..hypertrophy (LVH), myocardial fibrosis, diastolic dysfunction, and an increased risk for arrhythmias, sudden death and heart failure...
  27. Gender Specific Complications of Diabetic Autonomic Neuropathy: A New Mouse Model
    JONAS BERNARD GALPER; Fiscal Year: 2010
    ..DAN has been associated with an increased incidence of arrhythmia and sudden death in diabetics...
  28. Regulation and function of cGMP dependent protein kinase in cardiac hypertrophy
    Eiki Takimoto; Fiscal Year: 2013
    ..population develops cardiac hypertrophy which increases their risk of suffering from heart disease, and sudden death. We discovered that cardiac hypertrophy/ remodeling is ameliorated by enhancing intrinsic cGMP pathway with ..
  29. The effect of TLR4 inhibition on lung transplant ischemia-reperfusion injury
    PERRY ARTHUR GENOVA; Fiscal Year: 2010
    ..If lungs could be retrieved from non-heart-beating donors (NHBDs) - victims of sudden death - at intervals after circulatory arrest and transplanted safely, the shortage of lungs for transplant could be ..
  30. PHOSPHORYLATION AND ENDOTHELIAL NITRIC OXIDE PRODUCTION
    William C Sessa; Fiscal Year: 2013
    ..and coronary atherosclerosis in a unique murine model leading to spontaneous myocardial infarction and sudden death. In vitro studies support the importance of Akt1 as a key survival pathway in all cell types relevant to ..
  31. Statins protect against adverse cardiac events during pneumonia
    Carlos J Orihuela; Fiscal Year: 2012
    ..by applicant): Individuals hospitalized for community-acquired pneumonia (CAP) are at increased risk for sudden death as a result of adverse cardiac events...
  32. Disease Mechanisms in ARVC
    Jeffrey E Saffitz; Fiscal Year: 2013
    ..it's highly variable genetic penetrance indicates the presence of powerful modifiers of the risk of sudden death. Future studies to define these modifiers could identify new targets for mechanism-based therapies to prevent ..
  33. Renin angiotensin system and connexin43
    Samuel C Dudley; Fiscal Year: 2013
    ..induced arrhythmias, we developed a cardiac-restricted ACE overexpression mouse that shows an increased risk of sudden death in the absence of heart failure or structural heart disease...
  34. The Ventral Medulla and the Sudden Infant Death Syndrome
    HANNAH CHASE KINNEY; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The sudden infant death syndrome (SIDS) is the sudden death of an infant that remains unexplained after a complete review of the history, autopsy, and death scene investigation;it is the leading cause ..
  35. Titin Splicing Mechanisms and Physical Implications
    Marion L Greaser; Fiscal Year: 2010
    ..In addition the rat mutation model we have developed should help to understand mechanisms of cardiac arrhythmia and sudden death.
  36. EVOLVING MECHANICS OF INTRALUMINAL THROMBUS: FROM FORMATION TO ORGANIZATION
    Jay D Humphrey; Fiscal Year: 2010
    ..thrombus is the acute occlusion of a coronary artery following rupture of a vulnerable plaque, which can cause sudden death. In addition, however, ~75% of abdominal aortic aneurysms involve an intraluminal thrombus, which is thought to ..
  37. Chlorinated Lipids in Myocardial Ischemia/Reperfusion
    David A Ford; Fiscal Year: 2013
    Coronary heart disease is responsible for the sudden death of over 500,000 U.S. citizens per year...
  38. The Role of the Proteasome in Troponin related Cardiomyopathies
    ALDRIN VERNO GOMES; Fiscal Year: 2013
    ..Patients carrying these FHC related cTnT mutations show a high incidence of sudden death without the classical increase in the left ventricular heart wall seen in FHC patients with mutations in other ..
  39. Role of Sterols and Insulin in Cardiac Autonomic Response
    JONAS BERNARD GALPER; Fiscal Year: 2013
    ..Furthermore, there is a marked increase in the incidence of sudden death in diabetics which may be associated, at least in part, with a decrease in parasympathetic responsiveness of ..
  40. Cardiac Channel Mutations in SIDS
    MICHAEL JOHN ACKERMAN; Fiscal Year: 2013
    ..However, the fundamental causes of SIDS remain poorly understood. Underlying genetic susceptibility for sudden death, involving genetic determinants of the central nervous system and serotonergic signaling, immune dysfunction, ..
  41. Aldosterone, nitric oxide, myocardial fibrosis, and capillary loss in ESRD
    David M Charytan; Fiscal Year: 2013
    ..b>Sudden death accounts for the vast majority of CV deaths in individuals with ESRD, with a 5-folder higher frequency than ..
  42. Gap Junction Trafficking to and within the Plasma Membrane
    ROBIN MARK SHAW; Fiscal Year: 2013
    ..The cellular basis of both heart failure and sudden death involve diminished electrical coupling between heart cells...
  43. The Comparative Effectiveness of Single versus Dual Chamber Cardioverter Defibril
    Pamela N Peterson; Fiscal Year: 2013
    ..PUBLIC HEALTH RELEVANCE: Many patients with heart failure are at high risk for sudden death due to abnormal heart rhythms...
  44. Longtitudinal Study of Dialysis
    Rulan S Parekh; Fiscal Year: 2012
    ..large prospective cohort study of incident dialysis participants investigating risk factors for arrhythmias and sudden death. Results from the study will provide valuable insight into the relationship of vascular calcification with ..
  45. The mitochondrial calcium uniporter in sinus node physiology and disease
    TYLER PAUL RASMUSSEN; Fiscal Year: 2013
    ..by dysregulation of the primary cardiac pacemaker, slowing of the HR and increased risk of arrhythmias and sudden death. At present the only treatment for SND is surgical implantation of a permanent pacemaker, which costs 2 billion ..
  46. Fundamental Biology of SCD and its Application to Identify Patients at Risk
    GORDON FRANK TOMASELLI; Fiscal Year: 2013
    ..We will employ a surrogate of SCD in this study that will be referred to as arrhythmic sudden death (ASD) defined as adjudicated firings for ventricular tachycardia (VT) or ventricular fibrillation (VF) and ..
  47. Single Scan Rest/Stress Cardiac PET Imaging
    Arkadiusz Sitek; Fiscal Year: 2012
    ..Since the signal event of CAD is often sudden death or myocardial infarction, great energy has been focused on developing new noninvasive imaging technologies to ..
  48. PREDICTIVE GENES, MECHANISMS, AND CLINICAL BIOMARKERS OF SUDEP
    Jeffrey Noebels; Fiscal Year: 2013
    ..biomarkers obtained during epilepsy monitoring of individuals with Dravet Syndrome and others at high risk of sudden death (ictal hypoxemia, cardiac arrhythmia)...
  49. The role of Raf-MEK signaling in the pathogenesis of hypertrophic cardiomyopathy
    JASON BECKER; Fiscal Year: 2013
    ..by abnormal thickening of the ventricular myocardium, is a common genetic cause of heart failure and sudden death. The prevalence of this condition is 1:500, and over the last twenty years there has been tremendous ..
  50. AUTONOMIC CARDIOVASCULAR REGULATION
    DAVID HERLIE ROBERTSON; Fiscal Year: 2013
    ..to many forms of cardiovascular disease: arrhythmias, hypertension, syncope, stroke, myocardial infarction, and sudden death. The goal of this Program Project is to achieve better understanding of how the brain exerts control over the ..
  51. Calsequestrin in Ventricular Arrhythmia and Sudden Death
    Bjorn C Knollmann; Fiscal Year: 2013
    ..To test the hypothesis that Casq2 is reduced near RyR2 Ca release channels in cardiac muscle surviving after myocardial infarction ..
  52. More and Better Lungs: Ex-Vivo Perfusion of Lungs from Non-Heart-Beating Donors
    Thomas M Egan; Fiscal Year: 2013
    ..Each year, more than 750,000 people in the U.S. are victims of sudden death;if lungs could be retrieved for transplant from some of these people - non-heart-beating donors (NHBDs) - the ..
  53. Structure-Function of the Nuclear Envelope Bridge and its Role in Laminopathies
    Thomas U Schwartz; Fiscal Year: 2012
    ..of certain muscles, joint deformities and life-threatening heart problems that can result in premature and sudden death. There is currently no definitive therapy for Emery-Dreifuss muscular dystrophy or related diseases;therefore, ..
  54. The Role of the Transient Outward Current in Genetically Elusive Sudden Death
    John R Giudicessi; Fiscal Year: 2013
    ..in cardiac ion channel function represent the most common identifiable causes underlying autopsy negative sudden death, including 35% of Sudden Unexplained Death Syndrome (SUDS) and 10% of Sudden Infant Death Syndrome (SIDS) cases...
  55. An Animal Model of Diabetic Autonomic Neuropathy: Study of Mechanism and Therapy
    JONAS BERNARD GALPER; Fiscal Year: 2010
    ..Type I diabetics with evidence of DAN demonstrate a fivefold higher 5 year mortality and increased incidence of sudden death than those without DAN...
  56. Neuroplasticity Associated with Acute Toluene Inhalation
    JACOB THOMAS BECKLEY; Fiscal Year: 2013
    ..have profound adverse consequences, such as cognitive impairment, brain abnormalities, organ damage, and even sudden death, a result of inhalant-induced cardiac dysrhythmia...
  57. MOLECULAR BASIS FOR DRUG INDUCED CARDIOTOXICITY IN AIDS
    CRAIG CLARKSON; Fiscal Year: 2001
    ..is associated with a high incidence of polymorphic ventricular arrhythmias, torsade de pointes, and even sudden death. Other preliminary data from the applicant's laboratory suggest that cocaine also can block HERG encoded K ..
  58. Cincinnati Center of Excellence in Hemoglobinopathies Research
    Punam Malik; Fiscal Year: 2013
    ..SCD to generate TGFP1, a profibrotic thrombo-lnflammatory cytokine that mediates SCD cardio-renal disease and sudden death, by causing a profibrotic state and a unique restrictive cardiomyopathy (RCM) with secondary PAH...
  59. Molecular Mechanisms of RyR2-triggered Arrhythmias
    Hector H Valdivia; Fiscal Year: 2013
    ..cellular processes that may lead to aberrant electrical activity (ventricular arrhythmias), the main cause of sudden death (SD)...
  60. VANDERBILT CENTER FOR EDUCATION/RESEARCH ON THERAPEUTICS
    Wayne A Ray; Fiscal Year: 2010
    ..drug effects--1) SSRIs and birth defects, 2) ADHD drugs and adverse cardiovascular events, 3) Medications and sudden death, 4) Warfarin and antimicrobial interactions;three are educational programs-5) Improving use of therapy to ..
  61. ION CHANNEL REGULATION AND MODULATION IN CARDIAC MUSCLE
    Jeanne M Nerbonne; Fiscal Year: 2013
    ..are evident in a variety of cardiovascular diseases and are associated with increased risk of arrhythmias and sudden death. The mechanisms involved in Ito,f regulation in the normal heart and Ito,f remodeling in cardiac disease, ..
  62. Applications of Magnetic Resonance for Management of Ventricular Tachycardia
    Saman Nazarian; Fiscal Year: 2013
    ..validated by other groups, and was later shown to identify non-ischemic cardiomyopathy patients at high risk of sudden death. However, the benefits of such an approach remain unassessed in many other high-risk patient subsets...
  63. Autonomic consequences of brief seizures
    Mark Stewart; Fiscal Year: 2004
    ..In spite of an apparent pattern of increasing autonomic dysfunction with increasing seizure intensity, sudden death during a seizure is not limited to cases of status epilepticus or even generalized tonic-clonic seizures...
  64. NF-kB Inhibition of Lung Ischemia Repurfusion Injury
    Patrick Flood; Fiscal Year: 2009
    ..If lungs could be retrieved from non-heart-beating donors (NHBDs) - victims of sudden death - at intervals after circulatory arrest and transplanted safely, the shortage of lungs for transplant could be ..
  65. Using a Telemedicine System to Promote Patient Care Among Underserved Individuals
    Alfred Bove; Fiscal Year: 2009
    ..Untreated hypertension is associated with an increased risk for myocardial infractions, sudden death, stroke, and renal failure...
  66. IDENTIFYING HIGH RISK PATIENTS WITH SYNCOPE
    Wishwa Kapoor; Fiscal Year: 1991
    ..this study is to validate two models which categorize patients with syncope into high and low risk for either sudden death or diagnostic arrhythmias based on data available from the initial history, physical examination, and EKG...
  67. Neural Circulatory Control in the Long QT Syndrome
    Virend Somers; Fiscal Year: 2006
    The long QT syndrome (LQTS) is associated with risk for polymorphic ventricular tachycardia, syncope, and sudden death. Molecular genetic approaches have shown that these syndromes are explained by mutations in cardiac ion channel genes, ..
  68. Spontaneous Arousals in "CHIME" Infants at Risk for SIDS
    ROBERT DARNALL; Fiscal Year: 2006
    ..challenges during sleep, helping to protect the infant from potentially dangerous situations, even sudden death. Failure of arousal mechanisms may contribute to the etiology of SIDS...
  69. CTRIP Ex-vivo perfusion and ventilation of lungs to assess transplant suitability
    Thomas M Egan; Fiscal Year: 2010
    ..If lungs could be retrieved for LTX from some of the 3 million annual U.S. victims of sudden death - non-heart-beating donors (NHBDs) - then the lung donor shortage could be eliminated...
  70. MECHANISMS OF CARDIOTOXICITY OF ANTIPSYCHOTIC DRUGS
    David Flockhart; Fiscal Year: 2001
    ..to establish the mechanisms by which important antipsychotic drugs might bring about cardiac arrhythmias and sudden death. While a great deal of research over the past thirty years has resulted in the recent appearance of ..
  71. MODEL OF DYSRHYTHMIAS AFTER CONGENITAL HEART SURGERY
    Arthur Garson; Fiscal Year: 1991
    This study will continue animal research designed to model the problem of sudden death after repair of congenital heart defects such as tetralogy of Fallot (TOF)...