Genomes and Genes
Summary: Physiological changes that occur in bodies after death.
Publications290 found, 100 shown here
- Best practice in forensic entomology--standards and guidelinesJens Amendt
Institute of Forensic Medicine, University of Frankfurt, Kennedyallee 104, 60596, Frankfurt Main, Germany
Int J Legal Med 121:90-104. 2007....
- Human postmortem tissue: what quality markers matter?Ana D Stan
University of Texas Southwestern Medical Center at Dallas, Department of Psychiatry, 5323 Harry Hines Blvd, NE5 110F, Dallas, TX 75390 9127, USA
Brain Res 1123:1-11. 2006..g., thawed tissue, surgical tissue), that yielded unexpected quality indicators. These data also suggest that cases whose source was a Medical Examiner's office represent high tissue quality...
- RNA integrity in post-mortem samples: influencing parameters and implications on RT-qPCR assaysAntje Koppelkamm
Institute of Legal Medicine, Freiburg University Medical Center, Albertstrasse 9, 79104 Freiburg, Germany
Int J Legal Med 125:573-80. 2011..Thus, when working with post-mortem samples, we recommend generating degradation profiles for all transcripts of interest in order to reveal detection limits of RT-qPCR assays...
- Cadaveric volatile organic compounds released by decaying pig carcasses (Sus domesticus L.) in different biotopesJ Dekeirsschieter
Department of Functional and Evolutionary Entomology, Gembloux Agricultural University, 2 Passage des Deportes, 5030 Gembloux, Belgium
Forensic Sci Int 189:46-53. 2009..The main cadaveric VOCs are acids, cyclic hydrocarbons, oxygenated compounds, sulfur and nitrogen compounds. A better knowledge of the smell of death and their volatile constituents may have many applications in forensic sciences...
- A study of volatile organic compounds evolved from the decaying human bodyM Statheropoulos
School of Chemical Engineering, National Technical University of Athens NTUA, Sector I, 9 Iroon Polytechniou Str, 157 73 Athens, Greece
Forensic Sci Int 153:147-55. 2005..The study of the evolved VOCs appears to be a promising adjunct to the forensic pathologist as they may offer important information which can be used in his final evaluation...
- Early post-mortem changes and stages of decomposition in exposed cadaversM Lee Goff
Chaminade University of Honolulu, Honolulu, HI 96816, USA
Exp Appl Acarol 49:21-36. 2009..Here these stages are characterized by physical parameters and related assemblages of arthropods, to provide a framework for consideration of the decomposition process and acarine relationships to the body...
- Yearly activity patterns in southern Victoria (Australia) of seasonally active carrion insectsM S Archer
Department of Zoology, The University of Melbourne, Melbourne, VIC 3010, Australia
Forensic Sci Int 132:173-6. 2003..Ten seasonally active taxa, likely to leave durable remnants of their presence were selected, and profiles were constructed of their activity times over the 2-year study...
- A preliminary investigation of insect colonisation and succession on remains in New ZealandTerry L Eberhardt
The University of Auckland, Department of Chemistry, Forensic Science Programme, Building 301, Level 5, 23 Symonds St, Auckland, New Zealand
Forensic Sci Int 176:217-23. 2008..This preliminary investigation presents a broad outline of the insects associated with remains and the order in which they appear in the Auckland region...
- Successful RNA extraction from various human postmortem tissuesMarielle Heinrich
Institute of Legal Medicine, University of Freiburg, Albertstr 9, 79104, Freiburg, Germany
Int J Legal Med 121:136-42. 2007....
- A microarray study of post-mortem mRNA degradation in mouse brain tissueVibeke Sørensen Catts
Queensland Brain Institute, University of Queensland, Brisbane QLD 4072, Australia
Brain Res Mol Brain Res 138:164-77. 2005..This would particularly have ramifications for microarray studies that include a broad spectrum of genes...
- Intrahepatic gas at postmortem computed tomography: forensic experience as a potential guide for in vivo trauma imagingChristian Jackowski
Institute of Forensic Medicine, University of Bern, Switzerland
J Trauma 62:979-88. 2007..Intrahepatic gas (IHG) was a frequent finding in postmortem MSCT examinations. The aim of this study was to investigate its cause and significance...
- RNA in forensic scienceM Bauer
Institute of Legal Medicine, University of Bonn, Bonn, Germany
Forensic Sci Int Genet 1:69-74. 2007..This review explains and discusses principles, techniques and applications by offering a complete and comprehensive overview of research results in forensic RNA work...
- Factors affecting decomposition and Diptera colonizationC P Campobasso
Section of Legal Medicine (DI.M.I.M.P, University of Bari, Piazza Giulio Cesare, 70100 Policlinico-Bari, Italy
Forensic Sci Int 120:18-27. 2001..The sequence of postmortem changes in soft tissues usually gives an idea of how long an individual has been dead...
- Decomposition chemistry of human remains: a new methodology for determining the postmortem intervalArpad A Vass
Life Sciences Division, Oak Ridge National Laboratory, TN 37831 6101, USA
J Forensic Sci 47:542-53. 2002..Proper use of the methods described herein allow for PMIs so accurate that the estimate is limited by the ability to obtain correct temperature data at a crime scene rather than sample variability...
- Insect succession and decomposition patterns on shaded and sunlit carrion in Saskatchewan in three different seasonsBarbara J Sharanowski
University of Kentucky, Department of Entomology, S 225 Agricultural Science Center North, Lexington, KY 40546 0091, USA
Forensic Sci Int 179:219-40. 2008..Members of Silphidae were the first coleopteran colonizers in all habitats and seasons. This paper also marks the first record for Cochliomyia macellaria (Fabricius) in Saskatchewan...
- Estimation of the time since deathClaus Henssge
Institute of Forensic Medicine, University of Duisburg Essen, Hufelandstr 55, 45122 Essen, Germany
Forensic Sci Int 165:182-4. 2007..For practical purposes, it must be concluded that the amount of literature on estimating the time since death has a reverse correlation with its importance in practice...
- Hyperattenuating aortic wall on postmortem computed tomography (PMCT)Seiji Shiotani
Department of Radiology, Tsukuba Medical Center Hospital, Ibaraki, Japan
Radiat Med 20:201-6. 2002..To quantitatively evaluate the finding of hyperattenuating aortic wall on postmortem computed tomography (PMCT) and investigate its causes...
- Degradation profile of mRNA in a dead rat body: basic semi-quantification studyHiroshi Inoue
Department of Legal Medicine, Wakayama Medical University, Kimiidera 811 1, Wakayama 641 0012, Japan
Forensic Sci Int 130:127-32. 2002..In real-time RT-PCR analysis using GAPDH mRNA as an internal standard, the detection level of IL-1beta mRNA decreased in the postmortem interval. However, enhanced expression of IL-1beta was detected for at least 3 days postmortem...
- Non-traumatic postmortem computed tomographic (PMCT) findings of the lungSeiji Shiotani
Department of Diagnostic Radiology, Tsukuba Medical Center Hospital, 1 3 1 Amakubo, City, Ibaraki 305 8558, Tsukuba, Japan
Forensic Sci Int 139:39-48. 2004..We attempted to obtain postmortem computed tomographic (PMCT) images of the lung in cases of non-traumatic death and describe the results to distinguish usual postmortem findings from those of specific thoracic causes of death...
- Early defect of transforming growth factor β1 formation in Huntington's diseaseGiuseppe Battaglia
Neuropharmacology Unit, IRCCS Neuromed, Pozzilli, Italy
J Cell Mol Med 15:555-71. 2011....
- The composition of carcass volatile profiles in relation to storage time and climate conditionsJulia Kasper
Museum für Naturkunde Leibniz Institute for Research on Evolution and Biodiversity at the Humboldt University Berlin, Invalidenstrasse 43, 10115 Berlin, Germany
Forensic Sci Int 223:64-71. 2012..The relatively low amount of sulphur chemicals released under cd conditions were most striking. The results are discussed with respect to their possible applicability in forensic science and insect ecology studies...
- Dilatation of the heart on postmortem computed tomography (PMCT): comparison with live CTSeiji Shiotani
Department of Radiology, Tsukuba Medical Center Hospital, Ibaraki, Japan
Radiat Med 21:29-35. 2003..To delineate cardiac structures on postmortem computed tomography (PMCT) and quantitatively to prove dilatation of the heart after death...
- Progressive gas formation in a deceased person during mortuary storage demonstrated on computed tomographyMansharan Kaur Chainchel Singh
Faculty of Medicine, Universiti Teknologi Mara UiTM, Level 20, S and T Tower 1, 40450 Shah Alam, Selangor, Malaysia
Forensic Sci Med Pathol 5:236-42. 2009..This phenomenon must therefore be taken into account when interpreting the presence of visceral gas on postmortem CT and relating such gas to the cause of death...
- Postmortem changes of the thyroid on computed tomographyMasanori Ishida
Department of Radiology, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, Japan
Leg Med (Tokyo) 13:318-22. 2011..To evaluate the radiographic features of the thyroid on postmortem computed tomography (PMCT)...
- Factors and processes causing accelerated decomposition in human cadavers - An overviewChong Zhou
Discipline of Pathology, Level 3 Medical School North Building, The University of Adelaide, Frome Road, Adelaide, SA 5005, Australia
J Forensic Leg Med 18:6-9. 2011..When these factors or conditions are identified at autopsy less significance should, therefore, be attached to changes of decomposition as markers of time since death...
- Hypostasis in the heart and great vessels of non-traumatic in-hospital death cases on postmortem computed tomography: relationship to antemortem blood testsMasanori Ishida
Department of Radiology, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, Japan
Leg Med (Tokyo) 13:280-5. 2011....
- Intravascular gas distribution in the upper abdomen of non-traumatic in-hospital death cases on postmortem computed tomographyMasanori Ishida
Department of Radiology, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
Leg Med (Tokyo) 13:174-9. 2011....
- Epigenetic studies of psychosis: current findings, methodological approaches, and implications for postmortem researchRuth Pidsley
Institute of Psychiatry, King s College London, United Kingdom
Biol Psychiatry 69:146-56. 2011..In this article, we discuss methodologic and logistic issues related to epigenomic studies using postmortem brain tissue, before discussing the future implications of such research for our understanding of psychosis...
- Changes in aortic shape and diameters after death: comparison of early postmortem computed tomography with antemortem computed tomographyNaoya Takahashi
Department of Diagnostic Radiology, Niigata City General Hospital, Chuo Ku, Niigata, Japan
Forensic Sci Int 225:27-31. 2013..The purpose of this study is to evaluate the postmortem deformation of the aorta on postmortem computed tomography (CT) by comparison with the antemortem CT in the same patient...
- Postmortem imaging: MDCT features of postmortem change and decompositionAngela D Levy
Department of Radiology and Radiological Sciences, Uniformed Services University of the Health Sciences, Bethesda, MD, USA
Am J Forensic Med Pathol 31:12-7. 2010..Knowledge of the spectrum of postmortem change and decomposition is an important component of postmortem MDCT interpretation...
- Differential decomposition patterns in charred versus un-charred remainsAriel Gruenthal
School of Forensic and Investigative Sciences, University of Central Lancashire, Preston, UK
J Forensic Sci 57:12-8. 2012..Body regions displaying significant charring decomposed at a faster rate (p < 0.001), while areas with very light levels of charring decomposed at a significantly slower rate (p < 0.001)...
- Sex-specific proteome differences in the anterior cingulate cortex of schizophreniaDaniel Martins-de-Souza
Max Planck Institute of Psychiatry, Proteomics and Biomarkers, Kraepelinstr 2, 80804 Munich, Germany
J Psychiatr Res 44:989-91. 2010..Our findings not only support previous findings but also indicate areas that warrant further study in schizophrenia...
- Quantification of mRNA degradation as possible indicator of postmortem interval--a pilot studyMartin Bauer
Institute of Legal Medicine, University of Wuerzburg, Versbacher Strasse 3, D 97078 Wuerzburg, Germany
Leg Med (Tokyo) 5:220-7. 2003..However, rather large confidence intervals have to be considered so that the use of this method in forensic casework requires further research...
- Validation of adequate endogenous reference genes for the normalisation of qPCR gene expression data in human post mortem tissueAntje Koppelkamm
Institute of Legal Medicine, University of Freiburg, Albertstr 9, 79104, Freiburg, Germany
Int J Legal Med 124:371-80. 2010..The set of stable control genes identified in this study may be used in further studies if the composition of the samples is similar to the one used here...
- Seasonal patterns of arthropods occurring on sheltered and unsheltered pig carcasses in Buenos Aires Province (Argentina)N Centeno
Centro de Estudios e Investigaciones Programa de Investigaciones en Interacciones Biologicas CEI PIIB, Universidad Nacional de Quilmes, Roque Saenz Pena 180, Bernal, B1876BXD, Buenos Aires, Argentina
Forensic Sci Int 126:63-70. 2002..In the fall, the difference between sheltered and unsheltered carcasses was small (six species on the former and five species on the latter); in spring and summer, the difference was negligible...
- Genetic neuropathology of schizophrenia: new approaches to an old question and new uses for postmortem human brainsJoel E Kleinman
Section on Neuropathology, Clinical Brain Disorders Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
Biol Psychiatry 69:140-5. 2011..Moreover, the data, interpreted judiciously, can strengthen the plausibility of the association itself...
- Neurochemical markers for schizophrenia, bipolar disorder, and major depression in postmortem brainsE Fuller Torrey
Stanley Medical Research Institute, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA
Biol Psychiatry 57:252-60. 2005..Previous studies of postmortem neurochemical markers in severe psychiatric disorders have been carried out on different brain collections, making it difficult to compare results...
- NDM29, a RNA polymerase III-dependent non coding RNA, promotes amyloidogenic processing of APP and amyloid β secretionSara Massone
Department of Experimental Medicine, University of Genoa, Genoa, Italy
Biochim Biophys Acta 1823:1170-7. 2012....
- Expression of Nrf2 in neurodegenerative diseasesChenere P Ramsey
Department of Pathology, University of Pennsylvania, School of Dental Medicine, Philadelphia, Pennsylvania, USA
J Neuropathol Exp Neurol 66:75-85. 2007..In PD, nuclear localization of Nrf2 is strongly induced, but this response may be insufficient to protect neurons from degeneration...
- mRNA profiling in forensic genetics I: Possibilities and limitationsMarielle Vennemann
Institute of Legal Medicine, University of Freiburg, Albertstr 9, 79104 Freiburg, Germany
Forensic Sci Int 203:71-5. 2010..This review aims to give a brief overview of the possible advantages of postmortem mRNA profiling and to shed further light into the limitations of this method arising from reduced RNA integrities...
- The effects of larval crowding and food type on the size and development of the blowfly, Calliphora vomitoriaSarah Ireland
Department of Forensic Science and Drug Monitoring, King s College London, Franklin Wilkins Building, 150 Stamford Street, London SE1 9NH, UK
Forensic Sci Int 159:175-81. 2006..Variation in the extent of these effects was observed on each of the three body tissues, highlighting the importance of documenting the positions from which entomological evidence is recovered from a corpse...
- Growth rates of the blowfly, Lucilia sericata, on different body tissuesK Clark
School of Biological Sciences, University of Bristol, Woodland Road, Bristol BS8 1UG, UK
Forensic Sci Int 156:145-9. 2006....
- Puparial case hydrocarbons of Chrysomya megacephala as an indicator of the postmortem intervalGuang H Zhu
Department of Forensic Medicine, Shantou University Medical College, Shantou 515031, China
Forensic Sci Int 169:1-5. 2007..It is concluded that, cuticular hydrocarbon is a potential indicator of the weathering time in C. megacephala, and possibly in other necrophagous flies, and might further be used to determine the PMI...
- Succession pattern of carrion-feeding insects in Paramo, ColombiaEfrain Martinez
Grupo interdisciplinario de Estudios Moleculares GIEM, Universidad de Antioquia, AA, 1226 Medellin, Colombia
Forensic Sci Int 166:182-9. 2007..for dry remains. A succession table is presented for carrion-associated species of the region, which can be used for estimating time since death in similar areas. Compsomyiops boliviana is reported for the first time in Colombia...
- Time of death dependent criteria in vitreous humor: accuracy of estimating the time since deathBurkhard Madea
Institute of Legal Medicine, University of Bonn, Stiftsplatz 12, D 53111 Bonn, Germany
Forensic Sci Int 164:87-92. 2006..Only 153 cases have been within the predicted postmortem interval, 339 lay outside with a systematic overestimation of the time since death...
- Stability of RNA from the retina and retinal pigment epithelium in a porcine model simulating human eye bank conditionsKhurram J Malik
University of Minnesota, Department of Ophthalmology, Minneapolis, Minnesota 55455 0501, USA
Invest Ophthalmol Vis Sci 44:2730-5. 2003..To assess RNA stability after death in a porcine model to simulate current human eye bank techniques...
- Estimation of the time since death in the early post-mortem periodC Henssge
Institute of Forensic Medicine, University of Essen, Hufelandstr 55, 45122 Essen, Germany
Forensic Sci Int 144:167-75. 2004
- Noninvasive estimation of organ weights by postmortem magnetic resonance imaging and multislice computed tomographyChristian Jackowski
Institute of Forensic Medicine, Interventional and Pediatric Radiology, Inselspital, University of Bern, Switzerland
Invest Radiol 41:572-8. 2006..Computed tomography (CT) and magnetic resonance imaging (MRI) are introduced as an alternative to traditional autopsy. The purpose of this study was to investigate their accuracy in mass estimation of liver and spleen...
- Methods used for the killing and preservation of blowfly larvae, and their effect on post-mortem larval lengthZoe J O Adams
Department of Entomology, The Natural History Museum, SW7 5BD, UK
Forensic Sci Int 138:50-61. 2003..After long-term storage (290 days), larvae killed and preserved in the same way were on average 0.7% longer than immediately after death and 0.6% (0.11 mm) smaller than when last measured (after 28 days storage)...
- The effects of brain tissue decomposition on diffusion tensor imaging and tractographyHelen D'Arceuil
Athinoula Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, MGH NMR Center, Rm 2301, Bldg 149, 13th St, Charlestown, MA 02129, USA
Neuroimage 36:64-8. 2007..Elapsed time between death and tissue fixation has a major effect upon the brain's diffusion properties and should be born in mind when interpreting fixed brain DTI...
- Insect succession on a decomposing piglet carcass placed in a man-made freshwater pond in MalaysiaC C Heo
Department of Parasitology and Medical Entomology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300 Kuala Lumpur, Malaysia
Trop Biomed 25:23-9. 2008..There were very few adult flies, including a scarab beetle was sighted on the carcass at this stage. The carcass along with the maggots sunk on day tenth, leaving an oily layer on the water surface...
- Vitreous humor: biochemical constituents in estimation of postmortem intervalKusum D Jashnani
Department of Pathology, Topiwala National Medical College and B Y L Nair Charitable Hospital, Mumbai Central, Maharashtra 400 008, India
J Forensic Sci 55:1523-7. 2010..Hence, the findings of this study supported a central role of vitreous humor biochemistry in many postmortem forensic and pathological evaluations...
- Application of forensic entomology to postmortem interval determination of a burned human corpse: a homicide case report from southern TaiwanChung Yen Pai
Department of Forensic Science, Central Police University, Taiwan
J Formos Med Assoc 106:792-8. 2007..In this case, the PMI was estimated successfully and it was almost precise. It would appear that the more similar the surrounding environment between the mock study and the actual case, the more precise can be the PMI estimation...
- Postmortem interval alters the water relaxation and diffusion properties of rat nervous tissue--implications for MRI studies of human autopsy samplesTimothy M Shepherd
Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA 94143 0628, USA
Neuroimage 44:820-6. 2009..Thus, immersion fixation and/or even short PMIs (4-6 h) altered the MRI properties of rat nervous tissue. This suggests comparisons between in vivo clinical MRI and MRI data from human autopsy tissues should be interpreted with caution...
- Elevated formic acid concentrations in putrefied post-mortem blood and urine samplesJenni Viinamäki
Hjelt Institute, Department of Forensic Medicine, University of Helsinki, Helsinki, Finland
Forensic Sci Int 208:42-6. 2011..Poor correlation was shown between blood and urine concentrations of FA. Poor correlations were also shown, in both blood and urine, between methanol and FA concentrations...
- Analysis of mRNA from human heart tissue and putative applications in forensic molecular pathologySara Partemi
Institute of Forensic Medicine, Catholic University, Largo Francesco Vito 1, 00168 Rome, Italy
Forensic Sci Int 203:99-105. 2010....
- Postmortem changes of human bodies on the bathyal sea floor--two cases of aircraft accidents above the open seaThomas K Dumser
Department of Forensic Medicine and Medical Investigation of Aircraft Accidents, German Air Force Institute of Aviation Medicine, Fürstenfeldbruck, Germany
J Forensic Sci 53:1049-52. 2008....
- Determination of the early time of death by computerized image analysis of DNA degradation: which is the best quantitative indicator of DNA degradation?Lijiang Liu
Faculty of Forensic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
J Huazhong Univ Sci Technolog Med Sci 27:362-6. 2007....
- Low-temperature improved-throughput method for analysis of brain fatty acids and assessment of their post-mortem stabilityThomas Fraser
Dementia Research Group, Institute of Clinical Neurosciences, Clinical Science at North Bristol, University of Bristol, Frenchay Hospital, Frenchay, Bristol BS16 1LE, UK
J Neurosci Methods 169:135-40. 2008..The development of this method and the observation that delay of up to 3 days has no effect on fatty acid content will facilitate further studies of fatty acid composition on large cohorts of post-mortem brains...
- Gross and histologic postmortem changes of the skinCarrie Kovarik
University of Texas Southwestern Medical School, Department of Dermatology, Dallas, USA
Am J Forensic Med Pathol 26:305-8. 2005....
- Impact of neuregulin-1 on the pathophysiology of schizophrenia in human post-mortem studiesAndrea Schmitt
Dept of Psychiatry and Psychotherapy, University of Goettingen, Von Siebold Strasse 5, Gottingen, Germany
Eur Arch Psychiatry Clin Neurosci 258:35-9. 2008..In animal models of ischemia/hypoxia, NRG1 has been shown to act as a therapeutic, neuroprotective agent and should be investigated in more detail in transgenic animal models...
- Effect of the killing method on post-mortem change in length of larvae of Thanatophilus micans (Fabricius 1794) (Coleoptera: Silphidae) stored in 70% ethanolJohn M Midgley
Southern African Forensic Entomology Research Laboratory, Department of Zoology and Entomology, Rhodes University, Grahamstown, 6140, South Africa
Int J Legal Med 123:103-8. 2009..The results showed that T. micans larvae have a great potential for change in length during storage but that the change is not predictable, as the magnitude and sign of the change are variable...
- Width as an alternative measurement to length for post-mortem interval estimations using Calliphora augur (Diptera: Calliphoridae) larvaeDonnah M Day
Institute for Conservation Biology, School of Biological Sciences, University of Wollongong, Northfields Avenue, Wollongong, NSW 2522, Australia
Forensic Sci Int 159:158-67. 2006..augur grown at these temperatures. Furthermore, conversion of width to length can be done with 95% accuracy from a simple linear model...
- Collection of biological samples in forensic toxicologyR J Dinis-Oliveira
Institute of Legal Medicine, Faculty of Medicine, University of Porto, Porto, Portugal
Toxicol Mech Methods 20:363-414. 2010..This comprehensive review article is intented as a significant help for forensic toxicologists to accomplish their frequently overwhelming mission...
- Methodological considerations for gene expression profiling of human brainMary Atz
Department of Psychiatry and Human Behavior, College of Medicine, University of California, Irvine, CA, USA
J Neurosci Methods 163:295-309. 2007..We find that clinical, tissue, RNA, and microarray quality are all useful variables for collection and consideration in study design, analysis, and interpretation of gene expression results in human postmortem studies...
- Postmortem changes in the neuroanatomical characteristics of the primate brain: hippocampal formationPierre Lavenex
Department of Medicine, Unit of Physiology, University of Fribourg, 1700 Fribourg, Switzerland
J Comp Neurol 512:27-51. 2009..In conclusion, comparative studies of the brain must evaluate the effects of fixation on the staining pattern of each marker in every structure of interest before drawing conclusions about species differences...
- Quality control for microarray analysis of human brain samples: The impact of postmortem factors, RNA characteristics, and histopathologyS Weis
Stanley Laboratory for Brain Research and Neuropathology, Department of Psychiatry, Uniformed Services University of the Health Sciences, and Stanley Medical Research Institute, Bethesda, MD, USA
J Neurosci Methods 165:198-209. 2007....
- Is there recent progress in the estimation of the postmortem interval by means of thanatochemistry?Burkhard Madea
Institute of Forensic Medicine, University of Bonn, Stiftsplatz 12, 53111 Bonn, Germany
Forensic Sci Int 151:139-49. 2005..This is supported by the fact that field studies on the reliability and precision of death time estimation by chemical means are still scarce in the literature...
- Lewy body Parkinson's disease in a large pedigree with 77 Parkin mutation carriersPeter P Pramstaller
Department of Neurology, Central Hospital, Bolzano Bozen, Italy
Ann Neurol 58:411-22. 2005....
- Differential expression of the "C" and "T" alleles of the 5-HT2A receptor gene in the temporal cortex of normal individuals and schizophrenicsOxana O Polesskaya
Molecular Neurobiology Branch, National Institute on Drug Abuse, NIH, Baltimore, Maryland 21224, USA
J Neurosci Res 67:812-22. 2002..03). The data suggest that increased prevalence of allele "C" among schizophrenics may be due to intrinsically low expression of this allele, which may contribute to a deficit in 5-HT2AR expression in some schizophrenics...
- Effect of postmortem changes and freezing on the viscoelastic properties of vocal fold tissuesRoger W Chan
Vocal Fold Physiology and Biomechanics Laboratory, Department of Audiology and Speech Sciences, Purdue University, West Lafayette, IN 47907 1353, USA
Ann Biomed Eng 31:482-91. 2003..However, little is known about the biomechanical effects of postmortem changes and frozen storage in vocal fold tissues...
- Characterization of genetic miscoding lesions caused by postmortem damageM Thomas P Gilbert
Henry Wellcome Ancient Biomolecules Centre, Department of Zoology, Oxford University, Oxford, United Kingdom
Am J Hum Genet 72:48-61. 2003..Last, a significant correlation between archaeological site and sample-specific level of DNA damage was detected...
- DNA microarray analysis of postmortem brain tissueKaroly Mirnics
Department of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
Int Rev Neurobiol 60:153-81. 2004
- Effect of preservative solutions on preservation of Calliphora augur and Lucilia cuprina larvae (Diptera: Calliphoridae) with implications for post-mortem interval estimatesDonnah M Day
Institute for Conservation Biology, School of Biological Sciences, University of Wollongong, NSW 2522, Australia
Forensic Sci Int 179:1-10. 2008..It is concluded that the reaction to preservative type might be species specific and that different instars of the same species might also react differently...
- Molecular identification of some forensically important blowflies of southern Africa and AustraliaM L Harvey
Centre for Forensic Science, University of Western Australia, Australia
Med Vet Entomol 17:363-9. 2003..This region therefore appears to provide southern African forensic entomologists with a new technique for providing accurate identification for application to estimation of PMI...
- Brain pH has a significant impact on human postmortem hippocampal gene expression profilesS Mexal
Department of Psychiatry, University of Colorado at Denver and Health Sciences Center, Mail Stop 8344, PO Box 6511, Aurora, CO 80045, USA
Brain Res 1106:1-11. 2006..The predictive value of brain pH in an independent sample set was also greater than the disease, demonstrating that pH represents one of the most important control parameters in human postmortem gene expression studies in schizophrenia...
- The use of real-time PCR analysis in a gene expression study of Alzheimer's disease post-mortem brainsRamana V Gutala
Neurogenetics Laboratory, Neurological Sciences Institute, Oregon Health and Science University, Beaverton, OR 97006, USA
J Neurosci Methods 132:101-7. 2004..A comparative gene expression analysis also suggests that synaptophysin is down-regulated in AD brain specimens compared to control brain specimens...
- Effect of pre- and postmortem variables on specific mRNA levels in human brainW J Burke
Department of Neurology, Veterans Administration Medical Center, St Louis, MO
Brain Res Mol Brain Res 11:37-41. 1991..The possible effect of pre- and postmortem factors on specific mRNA levels should be investigated prior to comparing mRNA levels in different disease states...
- Distribution of neuropeptide Y interneurons in the dorsal prefrontal cortex of schizophreniaKenji Ikeda
Department of Schizophrenia Research, Tokyo Institute of Psychiatry, 2 1 8 Kamikitazawa, Setagaya, Tokyo 156 8585, Japan
Prog Neuropsychopharmacol Biol Psychiatry 28:379-83. 2004..These results also support the hypothesis of neurodevelopmental dysfunction of schizophrenia...
- Amygdalar activation alters the hippocampal GABA system: "partial" modelling for postmortem changes in schizophreniaS Berretta
Laboratory for Structural Neuroscience, Mailman Research Center, McLean Hospital, 115 Mill Street, Belmont, MA 02478, USA
J Comp Neurol 431:129-38. 2001..Such "partial" rodent modelling provides an important strategy for deciphering the effect of altered cortico-limbic circuits in SZ...
- Effect of agonal and postmortem factors on gene expression profile: quality control in microarray analyses of postmortem human brainHiroaki Tomita
Department of Psychiatry and Human Behavior, University of California Irvine, Irvine, CA 92697 1675, USA
Biol Psychiatry 55:346-52. 2004..Reducing the variance due to agonal factors is critical in investigating small but validated gene expression differences in messenger RNA levels between psychiatric patients and control subjects...
- Distribution and characterization of [3H]mesulergine binding in human brain postmortemD Marazziti
Dipartimento di Psichiatria, Neurobiologia, Farmacologia e Biotechnologie, University of Pisa, Italy
Eur Neuropsychopharmacol 10:21-6. 1999..These findings, showing a wide distribution of [3H]mesulergine binding sites in the human brain, could provide anatomical bases for the different functions attributable to 5-HT2C receptors in humans...
- Differential changes in apolipoprotein E in schizophrenia and bipolar I disorderAlison Digney
Rebecca L Cooper Research Laboratories, The Mental Health Research Institute of Victoria, Parkville, Victoria, Australia
Biol Psychiatry 57:711-5. 2005..This study extends an initial finding of increased levels of apoE in Brodmann's area (BA) 9 from subjects with schizophrenia to determine if apoE is altered in other brain regions and in brains from subjects with bipolar I disorder (BID)...
- Progress in the use of microarray technology to study the neurobiology of diseaseKaroly Mirnics
Department of Psychiatry, University of Pittsburgh, School of Medicine, E1453 Biomedical Science, Pittsburgh, Pennsylvania 15261, USA
Nat Neurosci 7:434-9. 2004..Nevertheless, recent microarray-based studies have implicated both individual dysregulated genes and abnormal patterns of gene expression in brain disorders...
- Brain protein preservation largely depends on the postmortem storage temperature: implications for study of proteins in human neurologic diseases and management of brain banks: a BrainNet Europe StudyIsidre Ferrer
Institut de Neuropatologia, Servei Anatomia Patològica, IDIBELL Hospital Universitari de Bellvitge, Universitat de Barcelona IF, 08907 Hospitalet de Llobregat, Barcelona, Spain
J Neuropathol Exp Neurol 66:35-46. 2007..These results emphasize the necessity of reducing the body temperature after death to minimize protein degradation...
- Mitochondrial-related gene expression changes are sensitive to agonal-pH state: implications for brain disordersM P Vawter
Department of Psychiatry, University of California, Irvine, USA
Mol Psychiatry 11:615, 663-79. 2006..Genes with the least sensitivity to agonal-pH could present a starting point for candidate gene search in neuropsychiatric disorders...
- Gene expression profiling in the post-mortem human brain--no cause for dismayS Bahn
Department of Neurobiology, Babraham Institute, CB2 4AT, Cambridge, UK
J Chem Neuroanat 22:79-94. 2001..The combination of laser-capture microdissection with high throughput profiling techniques offers opportunities to obtain precise genetic fingerprints of individual neurons allowing comparisons of normal and pathological states...
- Quantifying mRNA in postmortem human brain: influence of gender, age at death, postmortem interval, brain pH, agonal state and inter-lobe mRNA variancePaul Preece
Seixo Branco, Rua das Branas 7 Bajo D, 15177 Mera, A Coruna, Galicia, Spain
Brain Res Mol Brain Res 118:60-71. 2003..Given that gender, age at death and brain pH all have significant effects upon mRNA levels it is recommended that these factors be taken into account when quantifying gene expression in postmortem human brain...
- Mitochondrial DNA cytochrome oxidase I gene: potential for distinction between immature stages of some forensically important fly species (Diptera) in western AustraliaMichelle L Harvey
Centre for Forensic Science, The University of Western Australia, Nedlands 6009, Australia
Forensic Sci Int 131:134-9. 2003..Low levels of variation between some species of the same genus however indicate that further sequencing is required to locate a region for development of a molecular-based technique for identification...
- Biochemical and molecular studies using human autopsy brain tissueMatthew R Hynd
Department of Biochemistry, University of Queensland, Brisbane, Australia
J Neurochem 85:543-62. 2003..We conclude that valid and practical measures of a variety of parameters may be made in human brain tissue, provided that specific factors are controlled...
- Critical factors in gene expression in postmortem human brain: Focus on studies in schizophreniaBarbara K Lipska
Clinical Brain Disorders Branch, Division of Intramural Research Programs, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892 1385, USA
Biol Psychiatry 60:650-8. 2006..They are, however, confounded by pre- and postmortem factors. The purpose of this study was to identify sources of variation that will enable a better design of gene expression studies and higher reliability of gene expression data...
- Involvement of the endosomal-lysosomal system correlates with regional pathology in Creutzfeldt-Jakob diseaseGabor G Kovacs
Institute of Neurology, Medical University of Vienna, and Austrian Reference Center for Human Prion Diseases, Vienna, Austria
J Neuropathol Exp Neurol 66:628-36. 2007..Our results indicate that effects in the ELS correlate with regional pathology. Overloading of this system might impair the function of lysosomal enzymes and thus may mimic some features of lysosomal storage disorders...
- Recovery and expression of messenger RNA from postmortem human brain tissueT J Cummings
Department of Pathology, Duke University Medical Center, Box 3712, Durham, NC 27710, USA
Mod Pathol 14:1157-61. 2001..However, we caution that the successful expression of certain genes from postmortem brain tissue may require enhanced procurement efforts to maximize RNA integrity...
- Proteome analysis applied to meat science: characterizing postmortem changes in porcine muscleR Lametsch
Department of Animal Product Quality, Danish Institute of Agricultural Sciences, P.O. Box 50, DK-8830 Tjele, Denmark
J Agric Food Chem 49:4531-7. 2001..In this paper, of these changes we report the 15 most notable...
- Stability of RNA isolated from human trabecular bone at post-mortem and surgeryJulia S Kuliwaba
Bone and Joint Research Laboratory, Division of Tissue Pathology, Institute of Medical and Veterinary Science and Hanson Institute, Frome Road, Adelaide 5000, South Australia, Australia
Biochim Biophys Acta 1740:1-11. 2005....
- Real-time RT-PCR quantitative assays and postmortem degradation profiles of erythropoietin, vascular endothelial growth factor and hypoxia-inducible factor 1 alpha mRNA transcripts in forensic autopsy materialsDong Zhao
Department of Legal Medicine, Osaka City University Medical School, Asahi machi 1 4 3, Abeno, Osaka 545 8585, Japan
Leg Med (Tokyo) 8:132-6. 2006....
- Molecular identification of forensically important blow fly species (Diptera: Calliphoridae) in TaiwanWei Yun Chen
Department of Entomology, National Taiwan University, Taipei, Taiwan 106, Republic of China
J Med Entomol 41:47-57. 2004..A molecular primer key was ultimately constructed for the purpose of rapid and accurate species identification at the molecular level regardless of which stage or which part of a blow fly specimen is collected...
- The human brain revisited: opportunities and challenges in postmortem studies of psychiatric disordersDavid A Lewis
Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213, USA
Neuropsychopharmacology 26:143-54. 2002....
- Influence of post-mortem delay and storage temperature on the immunohistochemical detection of antigens in the CNS of miceHeidegard Hilbig
Institute of Anatomy, Leipzig University, 04103 Leipzig, Germany
Exp Toxicol Pathol 56:159-71. 2004..We found only marginal differences of alterations comparing neocortex, hippocampus and corpus callosum. Our results indicate that different antigens are affected differently by the ongoing catabolic processes during post-mortem delay...
- Early diagnosis of diffuse brain damage resulting from a blunt head injuryMamoru Ogata
Department of Legal Medicine, Graduate School of Medical and Dental Sciences, Kagoshima University, 8 35 1 Sakuragaoka, Kagoshima 890 8544, Japan
Leg Med (Tokyo) 9:105-8. 2007....
- Cathepsin D-mediated proteolysis of apolipoprotein E: possible role in Alzheimer's diseaseW Zhou
Department of Neurosurgery, University of Cincinnati College of Medicine, 231 Albert Sabin Way, Cincinnati, OH 45267 0515, USA
Neuroscience 143:689-701. 2006..These results suggest that aspartic proteases, catD in particular, may be involved in proteolysis of apoE and perhaps contribute to the generation of apoE fragments previously implicated in AD pathology...
- Biomarker Genes in Mood Disorder: Lymphocyte and BrainMARQUIS VAWTER; Fiscal Year: 2006..The potential use of biomarkers in lymphocytes will provide clinical researchers a tool to better address questions concerning diagnostic subgroups and treatment responders and non-responders. ..
- Pathogenesis Of Essential Tremor: Cerebellar MetabolismElan D Louis; Fiscal Year: 2012..We now wish to move beyond our initial work. SPECIFIC AIM 1 is to advance our knowledge of the postmortem changes in patients with cerebellar ET (Aim 1A) and Lewy body ET (Aim 1B) through detailed studies of PC neuronal ..
- DEVELOPMENT OF A PET RADIOTRACER FOR SIGMA-1 RECEPTORRikki Waterhouse; Fiscal Year: 2002..Yet, interpretation of postmortem changes in sigma-1 receptors has proven difficult, since most schizophrenics are on treatment prior to death...
- PKC and Cellular Signaling in the Suicide BrainGhanshyam Pandey; Fiscal Year: 2009..This knowledge may aid in developing better therapeutic strategies for the treatment of suicidal behavior. ..
- PI and Wnt Signaling in Postmortem Brain of Biopolar and Schizophrenia SubjectsGhanshyam N Pandey; Fiscal Year: 2011..This may eventually lead to i better understanding of the pathophysiology of BP or SZ illnesses and may aid in the development of more appropriate therapeutic agents for the treatment of these disorders. ..
- Prenatal Virally Induced Brain Disorder in MouseSEYYED FATEMI; Fiscal Year: 2009..In addition, it is expected that the results will provide clues that will lead to fundamental advances in our knowledge of the pathogenesis of schizophrenia and, therefore, of how it can be prevented and treated. ..
- Varenicline and Smoking Cessation in SchizophreniaSEYYED HOSSEIN FATEMI; Fiscal Year: 2010..Such outcomes will be significant, because they will offer a new treatment for smoking cessation in this vulnerable population. ..
- Hippocampal atrophy in major depressionCraig Stockmeier; Fiscal Year: 2007..Cellular changes detected in MDD postmortem may underlie hippocampal atrophy detected by some in living subjects with MDD. ..
- Mechanisms of Neurologic Disease CourseJAMES GEDDES; Fiscal Year: 2007..Dissemination of course materials will be through a course-specific web page and a multimedia CD. The course will be required for neuroscience trainees. [unreadable] [unreadable] [unreadable]..
- ALCOHOL, HIV, AND THE BRAINAdolf Pfefferbaum; Fiscal Year: 2006..Specific Aim 3: To establish cross-sectional and longitudinal within-subject relationships among nueroimaging, neuropsychological, and clinical measures. ..
- CaMKI, Apoptosis and Cholinergic Neurons in Aging and ADChangiz Geula; Fiscal Year: 2007..They will also form the basis of more comprehensive future studies aimed at determining the causes and effects of the alterations of the above genes. [unreadable] [unreadable] [unreadable]..
- ROLE OF PROTEASOMAL DYSFUNCTION IN PARKINSON'S DISEASEKEVIN MCNAUGHT; Fiscal Year: 2008..These studies will test our hypothesis that inadequate proteasomal function underlies both vulnerability and degeneration of the SNc in sporadic Parkinson's disease. ..
- Genomic Characterization in Depression and Suicide.Etienne Sibille; Fiscal Year: 2007..The training program proposes formal courses, supervised training and frequent interactions with several research groups involved in pioneering aspects of genomic research in mood disorders. [unreadable] [unreadable]..
- Signal Transduction in DepressionRichard Shelton; Fiscal Year: 2008..These studies may shed light on important cellular mediators of depression and provide new targets for amelioration. [unreadable] [unreadable]..
- Brain Development on Adults with SchizophreniaGeorge Bartzokis; Fiscal Year: 2008..This will change our concept of how we could treat this illness, the feasibility of changing its lifelong course, and would encourage the development of novel pharmacologic interventions to improve myelination. [unreadable] [unreadable]..
- The Basis of Psychotic Symptoms in Parkinson's DiseaseDeborah Mash; Fiscal Year: 2008..Recent publications from our group, our preliminary results, the brain tissue availability and the multidisciplinary team assembled provide strong support for the feasibility of this project. [unreadable] [unreadable] [unreadable]..
- Neurology of Attention and Neglect-A Network ApproachMarek Marsel Mesulam; Fiscal Year: 2008..The results of these experiments will help to understand the neurological bases of spatial attention and may lead to more rational treatments of hemispatial neglect. ..
- Hibernating Myocardium and Sudden Cardiac DeathJOHN CANTY; Fiscal Year: 2008..Our long-term objective is to develop better approaches to identify patients with CAD who are most likely to benefit from primary prevention of SCD with placement of an ICD. [unreadable] [unreadable]..
- AD LENS PATHOLOGY: BIOCHEMISTRY & DIAGNOSTIC IMAGINGLee E Goldstein; Fiscal Year: 2010..The resulting data may provide insights into fundamental mechanisms of AD-associated protein aeration and support development of novel AD diagnostic and monitoring technology. ..
- Dopamine Systems and Neuropsychiatric Changes in HIV/AIDSBenjamin B Gelman; Fiscal Year: 2010..The project breaks ground neuroscientifically, as no autopsy study has advanced to a "task specific" behavioral correlation with circuit level anomalies of a specific neurotransmitter system. ..
- Biological Predictors of Response to AntidepressantsRamin V Parsey; Fiscal Year: 2010..Our overall goal is to reduce the trial and error associated with finding an effective antidepressant by using data from pre-treatment quantification of 5-HT1A receptors and 5-HTT to guide antidepressant treatment selection. ..
- Metabolic Adaptation and Functional Recovery of Hibernating MyocardiumJohn M Canty; Fiscal Year: 2010..Our long-term objective is to use this research to develop new strategies to reverse myocardial dysfunction in patients with ischemic cardiomyoapthy which will reduce death and disability from heart failure and sudden death. ..
- Risk Factors and the Neurobiologic Substrate of FrailtyAron Buchman; Fiscal Year: 2009..abstract_text> ..
- Tissue Engineering of Cartilage using PeriosteumSHAWN O DRISCOLL; Fiscal Year: 2008..In addition, by eliminating the need for cell culture expansion facilities and expertise, the cost of this approach should be considerably less thereby making cartilage repair more globally accessible. ..
- Diffusion Tensor Imaging of Wallerian Degeneration in MSKhader Hasan; Fiscal Year: 2009..This tool will also help in the fusion of multi-modal MRI data for a robust segmentation of the subregions of CC and 1C. The DTI measures, after accounting for the age and gender dependence will be correlated with the clinical measures. ..
- Synaptic Apoptosis in SchizophreniaLEISA GLANTZ; Fiscal Year: 2008..abstract_text> ..
- Sleep, Circadian Rhythms and Dementing IllnessesDavid Harper; Fiscal Year: 2007..abstract_text> ..
- TEXAS REPOSITORY FOR AIDS NEUROPATHOGENESIS RESEARCHBenjamin Gelman; Fiscal Year: 2007..abstract_text> ..
- Cox-2 deficient mice are resistant to MPTP neurotoxicityGuoying Bing; Fiscal Year: 2007..abstract_text> ..
- MULTICENTER GENETIC STUDIES OF SCHIZOPHRENIABrien Riley; Fiscal Year: 2007..unreadable] [unreadable]..
- Rapid Screening Method: Gamma-hydroxybutyrate DetectionDeborah Mash; Fiscal Year: 2002..Both of these methods will be tested on GHB-spiked controls and residual blood and urine specimens obtained from the Miami-Dade County Medical Examiner Department and the Emergency Department of Jackson Memorial Hospital. ..
- MICROGLIA ACTIVATION INDUCES PARKINSONISM IN RATSGuoying Bing; Fiscal Year: 2002..abstract_text> ..
- Molecular Diagnosis Utilizing Cerebrospinal FluidSTEPHEN GINSBERG; Fiscal Year: 2003..abstract_text> ..
- Auditory Cortex: Regional Pathology In SchizophreniaRobert Sweet; Fiscal Year: 2003..abstract_text> ..
- Prefrontal Cell Pathology Distinguishes Mental DisordersGrazyna Rajkowska; Fiscal Year: 2003..The proposed study will illuminate disrupted cortical circuits involved in psychotic and depressed symptomatology and possibly cortical Sites of action for antidepressant and antipsychotic medications. ..
- PREVALENCE AND PROGRESSION OF DM2 RISK IN MA YOUTHDaniel Hale; Fiscal Year: 2004..abstract_text> ..
- MECHANICAL FACTORS IN CARTILAGE REPAIRSHAWN O DRISCOLL; Fiscal Year: 2004..It is felt that these findings will have relevance to other important area of orthopedics, including fracture healing, and have significant potential to impact the care of patients. ..
- ALCOHOL, HIV, AND THE BRAINAdolf Pfefferbaum; Fiscal Year: 2004..Specific Aim 3: To establish cross-sectional and longitudinal within-subject relationships among nueroimaging, neuropsychological, and clinical measures. ..
- MYELOPATHY AND NEUROPATHY DURING CHANGING HIV BURDENBenjamin Gelman; Fiscal Year: 2004..Together, the studies we have proposed will provide insights concerning prevalent AIDS morbidities in the HAART era. ..
- Lesion Induced Synaptic PlasticitySTEPHEN GINSBERG; Fiscal Year: 2004....
- Characterizing MRI parameters of iron-loaded tissuesMark Does; Fiscal Year: 2004..with computer simulations, will allow the detailed, quantitative comparison of biomagnetic and NMR data from individual animals whose tissue iron content can be determined quantitatively at the end of each experiment ..
- Auditory cortex asymmetry in normals and schizophrenicsJohn Smiley; Fiscal Year: 2007..unreadable] [unreadable]..
- Imaging of Serotonin Transporters in DepressionRAMIN PARSEY; Fiscal Year: 2005..These goals will be met by a combination of didactic I course work and supervision. ..
- HIV and the Proteasome in the Aging Human BrainBenjamin Gelman; Fiscal Year: 2005..The linkage between brain inflammation and altered neuronal protein turnover could lead to a unifying functional concept of dementia with application to HIV and aging both. ..
- Mood Disorders & Diabetes: Common Disease MechanismsWILLIAM REGENOLD; Fiscal Year: 2005..S. Such treatments could have the potential not only to provide symptom relief but also to repair and prevent the brain disease contributing to treatment resistance. ..
- Beta-glucocerebrosidase Mutations and PD in the AshkenazimLorraine Clark; Fiscal Year: 2006..Significantly, recent studies suggest that mutations in the GBA gene may be associated with Parkinson's disease and the lysosomal/autophagic pathway has also been implicated in PD pathogenesis. [unreadable] [unreadable]..
- Calpain Inhibition Strategies for Spinal Cord InjuryJAMES GEDDES; Fiscal Year: 2007..Together, the goal of the proposed studies is to develop effective strategies for calpain inhibition following SCI. ..
- MOLECULAR NEUROBIOLOGY OF DEPRESSIONRichard Shelton; Fiscal Year: 2003..Develop further expertise in basic molecular biological methods; 2. Develop new projects oriented to future funding opportunities; and 3. Continue to mentor the next generation of investigators. ..
- Prenatal Cannabis Effect on the Endocannabinoid SystemVINOD YARAGUDRI; Fiscal Year: 2008..unreadable] [unreadable] [unreadable]..
- Microglial interactions with amyloid beta peptideDouglas Walker; Fiscal Year: 2003..Overall, the findings from the proposed research could extend our knowledge of the inflammatory events occurring in the AD brain. ..
- AMYLOIDOGENIC EFFECTS OF CHOLINERGIC DENERVATIONThomas Beach; Fiscal Year: 2002..This could lead to impaired cerebral vasoregulation and increased susceptibility to ischemia, further compromising cortical function in AD. ..
- Isolation and Characterization of Cholinesterases From Plaques and TanglesChangiz Geula; Fiscal Year: 2008..unreadable] [unreadable] [unreadable]..
- COCHLEAR MECHANICSWILLIAM RHODE; Fiscal Year: 2007..Mechanical measurements will be compared I to auditory nerve responses in the same species and using the same signals. ..
- CALBINDIN AND CHOLINERGIC NEURONS IN AGING AND ADChangiz Geula; Fiscal Year: 2002....
- POSITIONAL CLONING OF A PLEIOTROPIC LOCUS FOR BEHAVIORHoward Gershenfeld; Fiscal Year: 2002..We hypothesize that the characterization of this exq1 locus will delineate a novel mechanism for regulating behavior and neuronal excitability and may lead to a target for rational drug design. ..