postmortem changes

Summary

Summary: Physiological changes that occur in bodies after death.

Top Publications

  1. ncbi Best practice in forensic entomology--standards and guidelines
    Jens Amendt
    Institute of Forensic Medicine, University of Frankfurt, Kennedyallee 104, 60596, Frankfurt Main, Germany
    Int J Legal Med 121:90-104. 2007
  2. pmc Human postmortem tissue: what quality markers matter?
    Ana D Stan
    University of Texas Southwestern Medical Center at Dallas, Department of Psychiatry, 5323 Harry Hines Blvd, NE5 110F, Dallas, TX 75390 9127, USA
    Brain Res 1123:1-11. 2006
  3. ncbi RNA integrity in post-mortem samples: influencing parameters and implications on RT-qPCR assays
    Antje Koppelkamm
    Institute of Legal Medicine, Freiburg University Medical Center, Albertstrasse 9, 79104 Freiburg, Germany
    Int J Legal Med 125:573-80. 2011
  4. ncbi Cadaveric volatile organic compounds released by decaying pig carcasses (Sus domesticus L.) in different biotopes
    J Dekeirsschieter
    Department of Functional and Evolutionary Entomology, Gembloux Agricultural University, 2 Passage des Deportes, 5030 Gembloux, Belgium
    Forensic Sci Int 189:46-53. 2009
  5. ncbi A study of volatile organic compounds evolved from the decaying human body
    M Statheropoulos
    School of Chemical Engineering, National Technical University of Athens NTUA, Sector I, 9 Iroon Polytechniou Str, 157 73 Athens, Greece
    Forensic Sci Int 153:147-55. 2005
  6. ncbi Early post-mortem changes and stages of decomposition in exposed cadavers
    M Lee Goff
    Chaminade University of Honolulu, Honolulu, HI 96816, USA
    Exp Appl Acarol 49:21-36. 2009
  7. ncbi Yearly activity patterns in southern Victoria (Australia) of seasonally active carrion insects
    M S Archer
    Department of Zoology, The University of Melbourne, Melbourne, VIC 3010, Australia
    Forensic Sci Int 132:173-6. 2003
  8. ncbi A preliminary investigation of insect colonisation and succession on remains in New Zealand
    Terry L Eberhardt
    The University of Auckland, Department of Chemistry, Forensic Science Programme, Building 301, Level 5, 23 Symonds St, Auckland, New Zealand
    Forensic Sci Int 176:217-23. 2008
  9. ncbi Successful RNA extraction from various human postmortem tissues
    Marielle Heinrich
    Institute of Legal Medicine, University of Freiburg, Albertstr 9, 79104, Freiburg, Germany
    Int J Legal Med 121:136-42. 2007
  10. ncbi A microarray study of post-mortem mRNA degradation in mouse brain tissue
    Vibeke Sørensen Catts
    Queensland Brain Institute, University of Queensland, Brisbane QLD 4072, Australia
    Brain Res Mol Brain Res 138:164-77. 2005

Research Grants

  1. Biomarker Genes in Mood Disorder: Lymphocyte and Brain
    MARQUIS VAWTER; Fiscal Year: 2006
  2. Pathogenesis Of Essential Tremor: Cerebellar Metabolism
    Elan D Louis; Fiscal Year: 2012
  3. DEVELOPMENT OF A PET RADIOTRACER FOR SIGMA-1 RECEPTOR
    Rikki Waterhouse; Fiscal Year: 2002
  4. PKC and Cellular Signaling in the Suicide Brain
    Ghanshyam Pandey; Fiscal Year: 2009
  5. PI and Wnt Signaling in Postmortem Brain of Biopolar and Schizophrenia Subjects
    Ghanshyam N Pandey; Fiscal Year: 2011
  6. Prenatal Virally Induced Brain Disorder in Mouse
    SEYYED FATEMI; Fiscal Year: 2009
  7. Varenicline and Smoking Cessation in Schizophrenia
    SEYYED HOSSEIN FATEMI; Fiscal Year: 2010
  8. Hippocampal atrophy in major depression
    Craig Stockmeier; Fiscal Year: 2007
  9. Mechanisms of Neurologic Disease Course
    JAMES GEDDES; Fiscal Year: 2007
  10. ALCOHOL, HIV, AND THE BRAIN
    Adolf Pfefferbaum; Fiscal Year: 2006

Detail Information

Publications290 found, 100 shown here

  1. ncbi Best practice in forensic entomology--standards and guidelines
    Jens Amendt
    Institute of Forensic Medicine, University of Frankfurt, Kennedyallee 104, 60596, Frankfurt Main, Germany
    Int J Legal Med 121:90-104. 2007
    ....
  2. pmc Human postmortem tissue: what quality markers matter?
    Ana D Stan
    University of Texas Southwestern Medical Center at Dallas, Department of Psychiatry, 5323 Harry Hines Blvd, NE5 110F, Dallas, TX 75390 9127, USA
    Brain Res 1123:1-11. 2006
    ..g., thawed tissue, surgical tissue), that yielded unexpected quality indicators. These data also suggest that cases whose source was a Medical Examiner's office represent high tissue quality...
  3. ncbi RNA integrity in post-mortem samples: influencing parameters and implications on RT-qPCR assays
    Antje Koppelkamm
    Institute of Legal Medicine, Freiburg University Medical Center, Albertstrasse 9, 79104 Freiburg, Germany
    Int J Legal Med 125:573-80. 2011
    ..Thus, when working with post-mortem samples, we recommend generating degradation profiles for all transcripts of interest in order to reveal detection limits of RT-qPCR assays...
  4. ncbi Cadaveric volatile organic compounds released by decaying pig carcasses (Sus domesticus L.) in different biotopes
    J Dekeirsschieter
    Department of Functional and Evolutionary Entomology, Gembloux Agricultural University, 2 Passage des Deportes, 5030 Gembloux, Belgium
    Forensic Sci Int 189:46-53. 2009
    ..The main cadaveric VOCs are acids, cyclic hydrocarbons, oxygenated compounds, sulfur and nitrogen compounds. A better knowledge of the smell of death and their volatile constituents may have many applications in forensic sciences...
  5. ncbi A study of volatile organic compounds evolved from the decaying human body
    M Statheropoulos
    School of Chemical Engineering, National Technical University of Athens NTUA, Sector I, 9 Iroon Polytechniou Str, 157 73 Athens, Greece
    Forensic Sci Int 153:147-55. 2005
    ..The study of the evolved VOCs appears to be a promising adjunct to the forensic pathologist as they may offer important information which can be used in his final evaluation...
  6. ncbi Early post-mortem changes and stages of decomposition in exposed cadavers
    M Lee Goff
    Chaminade University of Honolulu, Honolulu, HI 96816, USA
    Exp Appl Acarol 49:21-36. 2009
    ..Here these stages are characterized by physical parameters and related assemblages of arthropods, to provide a framework for consideration of the decomposition process and acarine relationships to the body...
  7. ncbi Yearly activity patterns in southern Victoria (Australia) of seasonally active carrion insects
    M S Archer
    Department of Zoology, The University of Melbourne, Melbourne, VIC 3010, Australia
    Forensic Sci Int 132:173-6. 2003
    ..Ten seasonally active taxa, likely to leave durable remnants of their presence were selected, and profiles were constructed of their activity times over the 2-year study...
  8. ncbi A preliminary investigation of insect colonisation and succession on remains in New Zealand
    Terry L Eberhardt
    The University of Auckland, Department of Chemistry, Forensic Science Programme, Building 301, Level 5, 23 Symonds St, Auckland, New Zealand
    Forensic Sci Int 176:217-23. 2008
    ..This preliminary investigation presents a broad outline of the insects associated with remains and the order in which they appear in the Auckland region...
  9. ncbi Successful RNA extraction from various human postmortem tissues
    Marielle Heinrich
    Institute of Legal Medicine, University of Freiburg, Albertstr 9, 79104, Freiburg, Germany
    Int J Legal Med 121:136-42. 2007
    ....
  10. ncbi A microarray study of post-mortem mRNA degradation in mouse brain tissue
    Vibeke Sørensen Catts
    Queensland Brain Institute, University of Queensland, Brisbane QLD 4072, Australia
    Brain Res Mol Brain Res 138:164-77. 2005
    ..This would particularly have ramifications for microarray studies that include a broad spectrum of genes...
  11. ncbi Intrahepatic gas at postmortem computed tomography: forensic experience as a potential guide for in vivo trauma imaging
    Christian Jackowski
    Institute of Forensic Medicine, University of Bern, Switzerland
    J Trauma 62:979-88. 2007
    ..Intrahepatic gas (IHG) was a frequent finding in postmortem MSCT examinations. The aim of this study was to investigate its cause and significance...
  12. ncbi RNA in forensic science
    M Bauer
    Institute of Legal Medicine, University of Bonn, Bonn, Germany
    Forensic Sci Int Genet 1:69-74. 2007
    ..This review explains and discusses principles, techniques and applications by offering a complete and comprehensive overview of research results in forensic RNA work...
  13. ncbi Factors affecting decomposition and Diptera colonization
    C P Campobasso
    Section of Legal Medicine (DI.M.I.M.P, University of Bari, Piazza Giulio Cesare, 70100 Policlinico-Bari, Italy
    Forensic Sci Int 120:18-27. 2001
    ..The sequence of postmortem changes in soft tissues usually gives an idea of how long an individual has been dead...
  14. ncbi Decomposition chemistry of human remains: a new methodology for determining the postmortem interval
    Arpad A Vass
    Life Sciences Division, Oak Ridge National Laboratory, TN 37831 6101, USA
    J Forensic Sci 47:542-53. 2002
    ..Proper use of the methods described herein allow for PMIs so accurate that the estimate is limited by the ability to obtain correct temperature data at a crime scene rather than sample variability...
  15. ncbi Insect succession and decomposition patterns on shaded and sunlit carrion in Saskatchewan in three different seasons
    Barbara J Sharanowski
    University of Kentucky, Department of Entomology, S 225 Agricultural Science Center North, Lexington, KY 40546 0091, USA
    Forensic Sci Int 179:219-40. 2008
    ..Members of Silphidae were the first coleopteran colonizers in all habitats and seasons. This paper also marks the first record for Cochliomyia macellaria (Fabricius) in Saskatchewan...
  16. ncbi Estimation of the time since death
    Claus Henssge
    Institute of Forensic Medicine, University of Duisburg Essen, Hufelandstr 55, 45122 Essen, Germany
    Forensic Sci Int 165:182-4. 2007
    ..For practical purposes, it must be concluded that the amount of literature on estimating the time since death has a reverse correlation with its importance in practice...
  17. ncbi Hyperattenuating aortic wall on postmortem computed tomography (PMCT)
    Seiji Shiotani
    Department of Radiology, Tsukuba Medical Center Hospital, Ibaraki, Japan
    Radiat Med 20:201-6. 2002
    ..To quantitatively evaluate the finding of hyperattenuating aortic wall on postmortem computed tomography (PMCT) and investigate its causes...
  18. ncbi Degradation profile of mRNA in a dead rat body: basic semi-quantification study
    Hiroshi Inoue
    Department of Legal Medicine, Wakayama Medical University, Kimiidera 811 1, Wakayama 641 0012, Japan
    Forensic Sci Int 130:127-32. 2002
    ..In real-time RT-PCR analysis using GAPDH mRNA as an internal standard, the detection level of IL-1beta mRNA decreased in the postmortem interval. However, enhanced expression of IL-1beta was detected for at least 3 days postmortem...
  19. ncbi Non-traumatic postmortem computed tomographic (PMCT) findings of the lung
    Seiji Shiotani
    Department of Diagnostic Radiology, Tsukuba Medical Center Hospital, 1 3 1 Amakubo, City, Ibaraki 305 8558, Tsukuba, Japan
    Forensic Sci Int 139:39-48. 2004
    ..We attempted to obtain postmortem computed tomographic (PMCT) images of the lung in cases of non-traumatic death and describe the results to distinguish usual postmortem findings from those of specific thoracic causes of death...
  20. ncbi Early defect of transforming growth factor β1 formation in Huntington's disease
    Giuseppe Battaglia
    Neuropharmacology Unit, IRCCS Neuromed, Pozzilli, Italy
    J Cell Mol Med 15:555-71. 2011
    ....
  21. ncbi The composition of carcass volatile profiles in relation to storage time and climate conditions
    Julia Kasper
    Museum für Naturkunde Leibniz Institute for Research on Evolution and Biodiversity at the Humboldt University Berlin, Invalidenstrasse 43, 10115 Berlin, Germany
    Forensic Sci Int 223:64-71. 2012
    ..The relatively low amount of sulphur chemicals released under cd conditions were most striking. The results are discussed with respect to their possible applicability in forensic science and insect ecology studies...
  22. ncbi Dilatation of the heart on postmortem computed tomography (PMCT): comparison with live CT
    Seiji Shiotani
    Department of Radiology, Tsukuba Medical Center Hospital, Ibaraki, Japan
    Radiat Med 21:29-35. 2003
    ..To delineate cardiac structures on postmortem computed tomography (PMCT) and quantitatively to prove dilatation of the heart after death...
  23. ncbi Progressive gas formation in a deceased person during mortuary storage demonstrated on computed tomography
    Mansharan Kaur Chainchel Singh
    Faculty of Medicine, Universiti Teknologi Mara UiTM, Level 20, S and T Tower 1, 40450 Shah Alam, Selangor, Malaysia
    Forensic Sci Med Pathol 5:236-42. 2009
    ..This phenomenon must therefore be taken into account when interpreting the presence of visceral gas on postmortem CT and relating such gas to the cause of death...
  24. ncbi Postmortem changes of the thyroid on computed tomography
    Masanori Ishida
    Department of Radiology, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, Japan
    Leg Med (Tokyo) 13:318-22. 2011
    ..To evaluate the radiographic features of the thyroid on postmortem computed tomography (PMCT)...
  25. ncbi Factors and processes causing accelerated decomposition in human cadavers - An overview
    Chong Zhou
    Discipline of Pathology, Level 3 Medical School North Building, The University of Adelaide, Frome Road, Adelaide, SA 5005, Australia
    J Forensic Leg Med 18:6-9. 2011
    ..When these factors or conditions are identified at autopsy less significance should, therefore, be attached to changes of decomposition as markers of time since death...
  26. ncbi Hypostasis in the heart and great vessels of non-traumatic in-hospital death cases on postmortem computed tomography: relationship to antemortem blood tests
    Masanori Ishida
    Department of Radiology, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, Japan
    Leg Med (Tokyo) 13:280-5. 2011
    ....
  27. ncbi Intravascular gas distribution in the upper abdomen of non-traumatic in-hospital death cases on postmortem computed tomography
    Masanori Ishida
    Department of Radiology, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Leg Med (Tokyo) 13:174-9. 2011
    ....
  28. ncbi Epigenetic studies of psychosis: current findings, methodological approaches, and implications for postmortem research
    Ruth Pidsley
    Institute of Psychiatry, King s College London, United Kingdom
    Biol Psychiatry 69:146-56. 2011
    ..In this article, we discuss methodologic and logistic issues related to epigenomic studies using postmortem brain tissue, before discussing the future implications of such research for our understanding of psychosis...
  29. ncbi Changes in aortic shape and diameters after death: comparison of early postmortem computed tomography with antemortem computed tomography
    Naoya Takahashi
    Department of Diagnostic Radiology, Niigata City General Hospital, Chuo Ku, Niigata, Japan
    Forensic Sci Int 225:27-31. 2013
    ..The purpose of this study is to evaluate the postmortem deformation of the aorta on postmortem computed tomography (CT) by comparison with the antemortem CT in the same patient...
  30. ncbi Postmortem imaging: MDCT features of postmortem change and decomposition
    Angela D Levy
    Department of Radiology and Radiological Sciences, Uniformed Services University of the Health Sciences, Bethesda, MD, USA
    Am J Forensic Med Pathol 31:12-7. 2010
    ..Knowledge of the spectrum of postmortem change and decomposition is an important component of postmortem MDCT interpretation...
  31. ncbi Differential decomposition patterns in charred versus un-charred remains
    Ariel Gruenthal
    School of Forensic and Investigative Sciences, University of Central Lancashire, Preston, UK
    J Forensic Sci 57:12-8. 2012
    ..Body regions displaying significant charring decomposed at a faster rate (p < 0.001), while areas with very light levels of charring decomposed at a significantly slower rate (p < 0.001)...
  32. ncbi Sex-specific proteome differences in the anterior cingulate cortex of schizophrenia
    Daniel Martins-de-Souza
    Max Planck Institute of Psychiatry, Proteomics and Biomarkers, Kraepelinstr 2, 80804 Munich, Germany
    J Psychiatr Res 44:989-91. 2010
    ..Our findings not only support previous findings but also indicate areas that warrant further study in schizophrenia...
  33. ncbi Quantification of mRNA degradation as possible indicator of postmortem interval--a pilot study
    Martin Bauer
    Institute of Legal Medicine, University of Wuerzburg, Versbacher Strasse 3, D 97078 Wuerzburg, Germany
    Leg Med (Tokyo) 5:220-7. 2003
    ..However, rather large confidence intervals have to be considered so that the use of this method in forensic casework requires further research...
  34. ncbi Validation of adequate endogenous reference genes for the normalisation of qPCR gene expression data in human post mortem tissue
    Antje Koppelkamm
    Institute of Legal Medicine, University of Freiburg, Albertstr 9, 79104, Freiburg, Germany
    Int J Legal Med 124:371-80. 2010
    ..The set of stable control genes identified in this study may be used in further studies if the composition of the samples is similar to the one used here...
  35. ncbi Seasonal patterns of arthropods occurring on sheltered and unsheltered pig carcasses in Buenos Aires Province (Argentina)
    N Centeno
    Centro de Estudios e Investigaciones Programa de Investigaciones en Interacciones Biologicas CEI PIIB, Universidad Nacional de Quilmes, Roque Saenz Pena 180, Bernal, B1876BXD, Buenos Aires, Argentina
    Forensic Sci Int 126:63-70. 2002
    ..In the fall, the difference between sheltered and unsheltered carcasses was small (six species on the former and five species on the latter); in spring and summer, the difference was negligible...
  36. ncbi Genetic neuropathology of schizophrenia: new approaches to an old question and new uses for postmortem human brains
    Joel E Kleinman
    Section on Neuropathology, Clinical Brain Disorders Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
    Biol Psychiatry 69:140-5. 2011
    ..Moreover, the data, interpreted judiciously, can strengthen the plausibility of the association itself...
  37. ncbi Neurochemical markers for schizophrenia, bipolar disorder, and major depression in postmortem brains
    E Fuller Torrey
    Stanley Medical Research Institute, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA
    Biol Psychiatry 57:252-60. 2005
    ..Previous studies of postmortem neurochemical markers in severe psychiatric disorders have been carried out on different brain collections, making it difficult to compare results...
  38. ncbi NDM29, a RNA polymerase III-dependent non coding RNA, promotes amyloidogenic processing of APP and amyloid β secretion
    Sara Massone
    Department of Experimental Medicine, University of Genoa, Genoa, Italy
    Biochim Biophys Acta 1823:1170-7. 2012
    ....
  39. pmc Expression of Nrf2 in neurodegenerative diseases
    Chenere P Ramsey
    Department of Pathology, University of Pennsylvania, School of Dental Medicine, Philadelphia, Pennsylvania, USA
    J Neuropathol Exp Neurol 66:75-85. 2007
    ..In PD, nuclear localization of Nrf2 is strongly induced, but this response may be insufficient to protect neurons from degeneration...
  40. ncbi mRNA profiling in forensic genetics I: Possibilities and limitations
    Marielle Vennemann
    Institute of Legal Medicine, University of Freiburg, Albertstr 9, 79104 Freiburg, Germany
    Forensic Sci Int 203:71-5. 2010
    ..This review aims to give a brief overview of the possible advantages of postmortem mRNA profiling and to shed further light into the limitations of this method arising from reduced RNA integrities...
  41. ncbi The effects of larval crowding and food type on the size and development of the blowfly, Calliphora vomitoria
    Sarah Ireland
    Department of Forensic Science and Drug Monitoring, King s College London, Franklin Wilkins Building, 150 Stamford Street, London SE1 9NH, UK
    Forensic Sci Int 159:175-81. 2006
    ..Variation in the extent of these effects was observed on each of the three body tissues, highlighting the importance of documenting the positions from which entomological evidence is recovered from a corpse...
  42. ncbi Growth rates of the blowfly, Lucilia sericata, on different body tissues
    K Clark
    School of Biological Sciences, University of Bristol, Woodland Road, Bristol BS8 1UG, UK
    Forensic Sci Int 156:145-9. 2006
    ....
  43. ncbi Puparial case hydrocarbons of Chrysomya megacephala as an indicator of the postmortem interval
    Guang H Zhu
    Department of Forensic Medicine, Shantou University Medical College, Shantou 515031, China
    Forensic Sci Int 169:1-5. 2007
    ..It is concluded that, cuticular hydrocarbon is a potential indicator of the weathering time in C. megacephala, and possibly in other necrophagous flies, and might further be used to determine the PMI...
  44. ncbi Succession pattern of carrion-feeding insects in Paramo, Colombia
    Efrain Martinez
    Grupo interdisciplinario de Estudios Moleculares GIEM, Universidad de Antioquia, AA, 1226 Medellin, Colombia
    Forensic Sci Int 166:182-9. 2007
    ..for dry remains. A succession table is presented for carrion-associated species of the region, which can be used for estimating time since death in similar areas. Compsomyiops boliviana is reported for the first time in Colombia...
  45. ncbi Time of death dependent criteria in vitreous humor: accuracy of estimating the time since death
    Burkhard Madea
    Institute of Legal Medicine, University of Bonn, Stiftsplatz 12, D 53111 Bonn, Germany
    Forensic Sci Int 164:87-92. 2006
    ..Only 153 cases have been within the predicted postmortem interval, 339 lay outside with a systematic overestimation of the time since death...
  46. ncbi Stability of RNA from the retina and retinal pigment epithelium in a porcine model simulating human eye bank conditions
    Khurram J Malik
    University of Minnesota, Department of Ophthalmology, Minneapolis, Minnesota 55455 0501, USA
    Invest Ophthalmol Vis Sci 44:2730-5. 2003
    ..To assess RNA stability after death in a porcine model to simulate current human eye bank techniques...
  47. ncbi Estimation of the time since death in the early post-mortem period
    C Henssge
    Institute of Forensic Medicine, University of Essen, Hufelandstr 55, 45122 Essen, Germany
    Forensic Sci Int 144:167-75. 2004
  48. ncbi Noninvasive estimation of organ weights by postmortem magnetic resonance imaging and multislice computed tomography
    Christian Jackowski
    Institute of Forensic Medicine, Interventional and Pediatric Radiology, Inselspital, University of Bern, Switzerland
    Invest Radiol 41:572-8. 2006
    ..Computed tomography (CT) and magnetic resonance imaging (MRI) are introduced as an alternative to traditional autopsy. The purpose of this study was to investigate their accuracy in mass estimation of liver and spleen...
  49. ncbi Methods used for the killing and preservation of blowfly larvae, and their effect on post-mortem larval length
    Zoe J O Adams
    Department of Entomology, The Natural History Museum, SW7 5BD, UK
    Forensic Sci Int 138:50-61. 2003
    ..After long-term storage (290 days), larvae killed and preserved in the same way were on average 0.7% longer than immediately after death and 0.6% (0.11 mm) smaller than when last measured (after 28 days storage)...
  50. pmc The effects of brain tissue decomposition on diffusion tensor imaging and tractography
    Helen D'Arceuil
    Athinoula Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, MGH NMR Center, Rm 2301, Bldg 149, 13th St, Charlestown, MA 02129, USA
    Neuroimage 36:64-8. 2007
    ..Elapsed time between death and tissue fixation has a major effect upon the brain's diffusion properties and should be born in mind when interpreting fixed brain DTI...
  51. ncbi Insect succession on a decomposing piglet carcass placed in a man-made freshwater pond in Malaysia
    C C Heo
    Department of Parasitology and Medical Entomology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300 Kuala Lumpur, Malaysia
    Trop Biomed 25:23-9. 2008
    ..There were very few adult flies, including a scarab beetle was sighted on the carcass at this stage. The carcass along with the maggots sunk on day tenth, leaving an oily layer on the water surface...
  52. ncbi Vitreous humor: biochemical constituents in estimation of postmortem interval
    Kusum D Jashnani
    Department of Pathology, Topiwala National Medical College and B Y L Nair Charitable Hospital, Mumbai Central, Maharashtra 400 008, India
    J Forensic Sci 55:1523-7. 2010
    ..Hence, the findings of this study supported a central role of vitreous humor biochemistry in many postmortem forensic and pathological evaluations...
  53. ncbi Application of forensic entomology to postmortem interval determination of a burned human corpse: a homicide case report from southern Taiwan
    Chung Yen Pai
    Department of Forensic Science, Central Police University, Taiwan
    J Formos Med Assoc 106:792-8. 2007
    ..In this case, the PMI was estimated successfully and it was almost precise. It would appear that the more similar the surrounding environment between the mock study and the actual case, the more precise can be the PMI estimation...
  54. pmc Postmortem interval alters the water relaxation and diffusion properties of rat nervous tissue--implications for MRI studies of human autopsy samples
    Timothy M Shepherd
    Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA 94143 0628, USA
    Neuroimage 44:820-6. 2009
    ..Thus, immersion fixation and/or even short PMIs (4-6 h) altered the MRI properties of rat nervous tissue. This suggests comparisons between in vivo clinical MRI and MRI data from human autopsy tissues should be interpreted with caution...
  55. ncbi Elevated formic acid concentrations in putrefied post-mortem blood and urine samples
    Jenni Viinamäki
    Hjelt Institute, Department of Forensic Medicine, University of Helsinki, Helsinki, Finland
    Forensic Sci Int 208:42-6. 2011
    ..Poor correlation was shown between blood and urine concentrations of FA. Poor correlations were also shown, in both blood and urine, between methanol and FA concentrations...
  56. ncbi Analysis of mRNA from human heart tissue and putative applications in forensic molecular pathology
    Sara Partemi
    Institute of Forensic Medicine, Catholic University, Largo Francesco Vito 1, 00168 Rome, Italy
    Forensic Sci Int 203:99-105. 2010
    ....
  57. ncbi Postmortem changes of human bodies on the bathyal sea floor--two cases of aircraft accidents above the open sea
    Thomas K Dumser
    Department of Forensic Medicine and Medical Investigation of Aircraft Accidents, German Air Force Institute of Aviation Medicine, Fürstenfeldbruck, Germany
    J Forensic Sci 53:1049-52. 2008
    ....
  58. ncbi Determination of the early time of death by computerized image analysis of DNA degradation: which is the best quantitative indicator of DNA degradation?
    Lijiang Liu
    Faculty of Forensic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
    J Huazhong Univ Sci Technolog Med Sci 27:362-6. 2007
    ....
  59. ncbi Low-temperature improved-throughput method for analysis of brain fatty acids and assessment of their post-mortem stability
    Thomas Fraser
    Dementia Research Group, Institute of Clinical Neurosciences, Clinical Science at North Bristol, University of Bristol, Frenchay Hospital, Frenchay, Bristol BS16 1LE, UK
    J Neurosci Methods 169:135-40. 2008
    ..The development of this method and the observation that delay of up to 3 days has no effect on fatty acid content will facilitate further studies of fatty acid composition on large cohorts of post-mortem brains...
  60. ncbi Gross and histologic postmortem changes of the skin
    Carrie Kovarik
    University of Texas Southwestern Medical School, Department of Dermatology, Dallas, USA
    Am J Forensic Med Pathol 26:305-8. 2005
    ....
  61. ncbi Impact of neuregulin-1 on the pathophysiology of schizophrenia in human post-mortem studies
    Andrea Schmitt
    Dept of Psychiatry and Psychotherapy, University of Goettingen, Von Siebold Strasse 5, Gottingen, Germany
    Eur Arch Psychiatry Clin Neurosci 258:35-9. 2008
    ..In animal models of ischemia/hypoxia, NRG1 has been shown to act as a therapeutic, neuroprotective agent and should be investigated in more detail in transgenic animal models...
  62. ncbi Effect of the killing method on post-mortem change in length of larvae of Thanatophilus micans (Fabricius 1794) (Coleoptera: Silphidae) stored in 70% ethanol
    John M Midgley
    Southern African Forensic Entomology Research Laboratory, Department of Zoology and Entomology, Rhodes University, Grahamstown, 6140, South Africa
    Int J Legal Med 123:103-8. 2009
    ..The results showed that T. micans larvae have a great potential for change in length during storage but that the change is not predictable, as the magnitude and sign of the change are variable...
  63. ncbi Width as an alternative measurement to length for post-mortem interval estimations using Calliphora augur (Diptera: Calliphoridae) larvae
    Donnah M Day
    Institute for Conservation Biology, School of Biological Sciences, University of Wollongong, Northfields Avenue, Wollongong, NSW 2522, Australia
    Forensic Sci Int 159:158-67. 2006
    ..augur grown at these temperatures. Furthermore, conversion of width to length can be done with 95% accuracy from a simple linear model...
  64. ncbi Collection of biological samples in forensic toxicology
    R J Dinis-Oliveira
    Institute of Legal Medicine, Faculty of Medicine, University of Porto, Porto, Portugal
    Toxicol Mech Methods 20:363-414. 2010
    ..This comprehensive review article is intented as a significant help for forensic toxicologists to accomplish their frequently overwhelming mission...
  65. pmc Methodological considerations for gene expression profiling of human brain
    Mary Atz
    Department of Psychiatry and Human Behavior, College of Medicine, University of California, Irvine, CA, USA
    J Neurosci Methods 163:295-309. 2007
    ..We find that clinical, tissue, RNA, and microarray quality are all useful variables for collection and consideration in study design, analysis, and interpretation of gene expression results in human postmortem studies...
  66. pmc Postmortem changes in the neuroanatomical characteristics of the primate brain: hippocampal formation
    Pierre Lavenex
    Department of Medicine, Unit of Physiology, University of Fribourg, 1700 Fribourg, Switzerland
    J Comp Neurol 512:27-51. 2009
    ..In conclusion, comparative studies of the brain must evaluate the effects of fixation on the staining pattern of each marker in every structure of interest before drawing conclusions about species differences...
  67. ncbi Quality control for microarray analysis of human brain samples: The impact of postmortem factors, RNA characteristics, and histopathology
    S Weis
    Stanley Laboratory for Brain Research and Neuropathology, Department of Psychiatry, Uniformed Services University of the Health Sciences, and Stanley Medical Research Institute, Bethesda, MD, USA
    J Neurosci Methods 165:198-209. 2007
    ....
  68. ncbi Is there recent progress in the estimation of the postmortem interval by means of thanatochemistry?
    Burkhard Madea
    Institute of Forensic Medicine, University of Bonn, Stiftsplatz 12, 53111 Bonn, Germany
    Forensic Sci Int 151:139-49. 2005
    ..This is supported by the fact that field studies on the reliability and precision of death time estimation by chemical means are still scarce in the literature...
  69. ncbi Lewy body Parkinson's disease in a large pedigree with 77 Parkin mutation carriers
    Peter P Pramstaller
    Department of Neurology, Central Hospital, Bolzano Bozen, Italy
    Ann Neurol 58:411-22. 2005
    ....
  70. ncbi Differential expression of the "C" and "T" alleles of the 5-HT2A receptor gene in the temporal cortex of normal individuals and schizophrenics
    Oxana O Polesskaya
    Molecular Neurobiology Branch, National Institute on Drug Abuse, NIH, Baltimore, Maryland 21224, USA
    J Neurosci Res 67:812-22. 2002
    ..03). The data suggest that increased prevalence of allele "C" among schizophrenics may be due to intrinsically low expression of this allele, which may contribute to a deficit in 5-HT2AR expression in some schizophrenics...
  71. ncbi Effect of postmortem changes and freezing on the viscoelastic properties of vocal fold tissues
    Roger W Chan
    Vocal Fold Physiology and Biomechanics Laboratory, Department of Audiology and Speech Sciences, Purdue University, West Lafayette, IN 47907 1353, USA
    Ann Biomed Eng 31:482-91. 2003
    ..However, little is known about the biomechanical effects of postmortem changes and frozen storage in vocal fold tissues...
  72. pmc Characterization of genetic miscoding lesions caused by postmortem damage
    M Thomas P Gilbert
    Henry Wellcome Ancient Biomolecules Centre, Department of Zoology, Oxford University, Oxford, United Kingdom
    Am J Hum Genet 72:48-61. 2003
    ..Last, a significant correlation between archaeological site and sample-specific level of DNA damage was detected...
  73. ncbi DNA microarray analysis of postmortem brain tissue
    Karoly Mirnics
    Department of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    Int Rev Neurobiol 60:153-81. 2004
  74. ncbi Effect of preservative solutions on preservation of Calliphora augur and Lucilia cuprina larvae (Diptera: Calliphoridae) with implications for post-mortem interval estimates
    Donnah M Day
    Institute for Conservation Biology, School of Biological Sciences, University of Wollongong, NSW 2522, Australia
    Forensic Sci Int 179:1-10. 2008
    ..It is concluded that the reaction to preservative type might be species specific and that different instars of the same species might also react differently...
  75. ncbi Molecular identification of some forensically important blowflies of southern Africa and Australia
    M L Harvey
    Centre for Forensic Science, University of Western Australia, Australia
    Med Vet Entomol 17:363-9. 2003
    ..This region therefore appears to provide southern African forensic entomologists with a new technique for providing accurate identification for application to estimation of PMI...
  76. ncbi Brain pH has a significant impact on human postmortem hippocampal gene expression profiles
    S Mexal
    Department of Psychiatry, University of Colorado at Denver and Health Sciences Center, Mail Stop 8344, PO Box 6511, Aurora, CO 80045, USA
    Brain Res 1106:1-11. 2006
    ..The predictive value of brain pH in an independent sample set was also greater than the disease, demonstrating that pH represents one of the most important control parameters in human postmortem gene expression studies in schizophrenia...
  77. ncbi The use of real-time PCR analysis in a gene expression study of Alzheimer's disease post-mortem brains
    Ramana V Gutala
    Neurogenetics Laboratory, Neurological Sciences Institute, Oregon Health and Science University, Beaverton, OR 97006, USA
    J Neurosci Methods 132:101-7. 2004
    ..A comparative gene expression analysis also suggests that synaptophysin is down-regulated in AD brain specimens compared to control brain specimens...
  78. ncbi Effect of pre- and postmortem variables on specific mRNA levels in human brain
    W J Burke
    Department of Neurology, Veterans Administration Medical Center, St Louis, MO
    Brain Res Mol Brain Res 11:37-41. 1991
    ..The possible effect of pre- and postmortem factors on specific mRNA levels should be investigated prior to comparing mRNA levels in different disease states...
  79. ncbi Distribution of neuropeptide Y interneurons in the dorsal prefrontal cortex of schizophrenia
    Kenji Ikeda
    Department of Schizophrenia Research, Tokyo Institute of Psychiatry, 2 1 8 Kamikitazawa, Setagaya, Tokyo 156 8585, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 28:379-83. 2004
    ..These results also support the hypothesis of neurodevelopmental dysfunction of schizophrenia...
  80. ncbi Amygdalar activation alters the hippocampal GABA system: "partial" modelling for postmortem changes in schizophrenia
    S Berretta
    Laboratory for Structural Neuroscience, Mailman Research Center, McLean Hospital, 115 Mill Street, Belmont, MA 02478, USA
    J Comp Neurol 431:129-38. 2001
    ..Such "partial" rodent modelling provides an important strategy for deciphering the effect of altered cortico-limbic circuits in SZ...
  81. pmc Effect of agonal and postmortem factors on gene expression profile: quality control in microarray analyses of postmortem human brain
    Hiroaki Tomita
    Department of Psychiatry and Human Behavior, University of California Irvine, Irvine, CA 92697 1675, USA
    Biol Psychiatry 55:346-52. 2004
    ..Reducing the variance due to agonal factors is critical in investigating small but validated gene expression differences in messenger RNA levels between psychiatric patients and control subjects...
  82. ncbi Distribution and characterization of [3H]mesulergine binding in human brain postmortem
    D Marazziti
    Dipartimento di Psichiatria, Neurobiologia, Farmacologia e Biotechnologie, University of Pisa, Italy
    Eur Neuropsychopharmacol 10:21-6. 1999
    ..These findings, showing a wide distribution of [3H]mesulergine binding sites in the human brain, could provide anatomical bases for the different functions attributable to 5-HT2C receptors in humans...
  83. ncbi Differential changes in apolipoprotein E in schizophrenia and bipolar I disorder
    Alison Digney
    Rebecca L Cooper Research Laboratories, The Mental Health Research Institute of Victoria, Parkville, Victoria, Australia
    Biol Psychiatry 57:711-5. 2005
    ..This study extends an initial finding of increased levels of apoE in Brodmann's area (BA) 9 from subjects with schizophrenia to determine if apoE is altered in other brain regions and in brains from subjects with bipolar I disorder (BID)...
  84. ncbi Progress in the use of microarray technology to study the neurobiology of disease
    Karoly Mirnics
    Department of Psychiatry, University of Pittsburgh, School of Medicine, E1453 Biomedical Science, Pittsburgh, Pennsylvania 15261, USA
    Nat Neurosci 7:434-9. 2004
    ..Nevertheless, recent microarray-based studies have implicated both individual dysregulated genes and abnormal patterns of gene expression in brain disorders...
  85. ncbi Brain protein preservation largely depends on the postmortem storage temperature: implications for study of proteins in human neurologic diseases and management of brain banks: a BrainNet Europe Study
    Isidre Ferrer
    Institut de Neuropatologia, Servei Anatomia Patològica, IDIBELL Hospital Universitari de Bellvitge, Universitat de Barcelona IF, 08907 Hospitalet de Llobregat, Barcelona, Spain
    J Neuropathol Exp Neurol 66:35-46. 2007
    ..These results emphasize the necessity of reducing the body temperature after death to minimize protein degradation...
  86. pmc Mitochondrial-related gene expression changes are sensitive to agonal-pH state: implications for brain disorders
    M P Vawter
    Department of Psychiatry, University of California, Irvine, USA
    Mol Psychiatry 11:615, 663-79. 2006
    ..Genes with the least sensitivity to agonal-pH could present a starting point for candidate gene search in neuropsychiatric disorders...
  87. ncbi Gene expression profiling in the post-mortem human brain--no cause for dismay
    S Bahn
    Department of Neurobiology, Babraham Institute, CB2 4AT, Cambridge, UK
    J Chem Neuroanat 22:79-94. 2001
    ..The combination of laser-capture microdissection with high throughput profiling techniques offers opportunities to obtain precise genetic fingerprints of individual neurons allowing comparisons of normal and pathological states...
  88. ncbi Quantifying mRNA in postmortem human brain: influence of gender, age at death, postmortem interval, brain pH, agonal state and inter-lobe mRNA variance
    Paul Preece
    Seixo Branco, Rua das Branas 7 Bajo D, 15177 Mera, A Coruna, Galicia, Spain
    Brain Res Mol Brain Res 118:60-71. 2003
    ..Given that gender, age at death and brain pH all have significant effects upon mRNA levels it is recommended that these factors be taken into account when quantifying gene expression in postmortem human brain...
  89. ncbi Mitochondrial DNA cytochrome oxidase I gene: potential for distinction between immature stages of some forensically important fly species (Diptera) in western Australia
    Michelle L Harvey
    Centre for Forensic Science, The University of Western Australia, Nedlands 6009, Australia
    Forensic Sci Int 131:134-9. 2003
    ..Low levels of variation between some species of the same genus however indicate that further sequencing is required to locate a region for development of a molecular-based technique for identification...
  90. ncbi Biochemical and molecular studies using human autopsy brain tissue
    Matthew R Hynd
    Department of Biochemistry, University of Queensland, Brisbane, Australia
    J Neurochem 85:543-62. 2003
    ..We conclude that valid and practical measures of a variety of parameters may be made in human brain tissue, provided that specific factors are controlled...
  91. ncbi Critical factors in gene expression in postmortem human brain: Focus on studies in schizophrenia
    Barbara K Lipska
    Clinical Brain Disorders Branch, Division of Intramural Research Programs, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892 1385, USA
    Biol Psychiatry 60:650-8. 2006
    ..They are, however, confounded by pre- and postmortem factors. The purpose of this study was to identify sources of variation that will enable a better design of gene expression studies and higher reliability of gene expression data...
  92. ncbi Involvement of the endosomal-lysosomal system correlates with regional pathology in Creutzfeldt-Jakob disease
    Gabor G Kovacs
    Institute of Neurology, Medical University of Vienna, and Austrian Reference Center for Human Prion Diseases, Vienna, Austria
    J Neuropathol Exp Neurol 66:628-36. 2007
    ..Our results indicate that effects in the ELS correlate with regional pathology. Overloading of this system might impair the function of lysosomal enzymes and thus may mimic some features of lysosomal storage disorders...
  93. ncbi Recovery and expression of messenger RNA from postmortem human brain tissue
    T J Cummings
    Department of Pathology, Duke University Medical Center, Box 3712, Durham, NC 27710, USA
    Mod Pathol 14:1157-61. 2001
    ..However, we caution that the successful expression of certain genes from postmortem brain tissue may require enhanced procurement efforts to maximize RNA integrity...
  94. ncbi Proteome analysis applied to meat science: characterizing postmortem changes in porcine muscle
    R Lametsch
    Department of Animal Product Quality, Danish Institute of Agricultural Sciences, P.O. Box 50, DK-8830 Tjele, Denmark
    J Agric Food Chem 49:4531-7. 2001
    ..In this paper, of these changes we report the 15 most notable...
  95. ncbi Stability of RNA isolated from human trabecular bone at post-mortem and surgery
    Julia S Kuliwaba
    Bone and Joint Research Laboratory, Division of Tissue Pathology, Institute of Medical and Veterinary Science and Hanson Institute, Frome Road, Adelaide 5000, South Australia, Australia
    Biochim Biophys Acta 1740:1-11. 2005
    ....
  96. ncbi Real-time RT-PCR quantitative assays and postmortem degradation profiles of erythropoietin, vascular endothelial growth factor and hypoxia-inducible factor 1 alpha mRNA transcripts in forensic autopsy materials
    Dong Zhao
    Department of Legal Medicine, Osaka City University Medical School, Asahi machi 1 4 3, Abeno, Osaka 545 8585, Japan
    Leg Med (Tokyo) 8:132-6. 2006
    ....
  97. ncbi Molecular identification of forensically important blow fly species (Diptera: Calliphoridae) in Taiwan
    Wei Yun Chen
    Department of Entomology, National Taiwan University, Taipei, Taiwan 106, Republic of China
    J Med Entomol 41:47-57. 2004
    ..A molecular primer key was ultimately constructed for the purpose of rapid and accurate species identification at the molecular level regardless of which stage or which part of a blow fly specimen is collected...
  98. ncbi The human brain revisited: opportunities and challenges in postmortem studies of psychiatric disorders
    David A Lewis
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Neuropsychopharmacology 26:143-54. 2002
    ....
  99. ncbi Influence of post-mortem delay and storage temperature on the immunohistochemical detection of antigens in the CNS of mice
    Heidegard Hilbig
    Institute of Anatomy, Leipzig University, 04103 Leipzig, Germany
    Exp Toxicol Pathol 56:159-71. 2004
    ..We found only marginal differences of alterations comparing neocortex, hippocampus and corpus callosum. Our results indicate that different antigens are affected differently by the ongoing catabolic processes during post-mortem delay...
  100. ncbi Early diagnosis of diffuse brain damage resulting from a blunt head injury
    Mamoru Ogata
    Department of Legal Medicine, Graduate School of Medical and Dental Sciences, Kagoshima University, 8 35 1 Sakuragaoka, Kagoshima 890 8544, Japan
    Leg Med (Tokyo) 9:105-8. 2007
    ....
  101. ncbi Cathepsin D-mediated proteolysis of apolipoprotein E: possible role in Alzheimer's disease
    W Zhou
    Department of Neurosurgery, University of Cincinnati College of Medicine, 231 Albert Sabin Way, Cincinnati, OH 45267 0515, USA
    Neuroscience 143:689-701. 2006
    ..These results suggest that aspartic proteases, catD in particular, may be involved in proteolysis of apoE and perhaps contribute to the generation of apoE fragments previously implicated in AD pathology...

Research Grants56

  1. Biomarker Genes in Mood Disorder: Lymphocyte and Brain
    MARQUIS VAWTER; Fiscal Year: 2006
    ..The potential use of biomarkers in lymphocytes will provide clinical researchers a tool to better address questions concerning diagnostic subgroups and treatment responders and non-responders. ..
  2. Pathogenesis Of Essential Tremor: Cerebellar Metabolism
    Elan D Louis; Fiscal Year: 2012
    ..We now wish to move beyond our initial work. SPECIFIC AIM 1 is to advance our knowledge of the postmortem changes in patients with cerebellar ET (Aim 1A) and Lewy body ET (Aim 1B) through detailed studies of PC neuronal ..
  3. DEVELOPMENT OF A PET RADIOTRACER FOR SIGMA-1 RECEPTOR
    Rikki Waterhouse; Fiscal Year: 2002
    ..Yet, interpretation of postmortem changes in sigma-1 receptors has proven difficult, since most schizophrenics are on treatment prior to death...
  4. PKC and Cellular Signaling in the Suicide Brain
    Ghanshyam Pandey; Fiscal Year: 2009
    ..This knowledge may aid in developing better therapeutic strategies for the treatment of suicidal behavior. ..
  5. PI and Wnt Signaling in Postmortem Brain of Biopolar and Schizophrenia Subjects
    Ghanshyam N Pandey; Fiscal Year: 2011
    ..This may eventually lead to i better understanding of the pathophysiology of BP or SZ illnesses and may aid in the development of more appropriate therapeutic agents for the treatment of these disorders. ..
  6. Prenatal Virally Induced Brain Disorder in Mouse
    SEYYED FATEMI; Fiscal Year: 2009
    ..In addition, it is expected that the results will provide clues that will lead to fundamental advances in our knowledge of the pathogenesis of schizophrenia and, therefore, of how it can be prevented and treated. ..
  7. Varenicline and Smoking Cessation in Schizophrenia
    SEYYED HOSSEIN FATEMI; Fiscal Year: 2010
    ..Such outcomes will be significant, because they will offer a new treatment for smoking cessation in this vulnerable population. ..
  8. Hippocampal atrophy in major depression
    Craig Stockmeier; Fiscal Year: 2007
    ..Cellular changes detected in MDD postmortem may underlie hippocampal atrophy detected by some in living subjects with MDD. ..
  9. Mechanisms of Neurologic Disease Course
    JAMES GEDDES; Fiscal Year: 2007
    ..Dissemination of course materials will be through a course-specific web page and a multimedia CD. The course will be required for neuroscience trainees. [unreadable] [unreadable] [unreadable]..
  10. ALCOHOL, HIV, AND THE BRAIN
    Adolf Pfefferbaum; Fiscal Year: 2006
    ..Specific Aim 3: To establish cross-sectional and longitudinal within-subject relationships among nueroimaging, neuropsychological, and clinical measures. ..
  11. CaMKI, Apoptosis and Cholinergic Neurons in Aging and AD
    Changiz Geula; Fiscal Year: 2007
    ..They will also form the basis of more comprehensive future studies aimed at determining the causes and effects of the alterations of the above genes. [unreadable] [unreadable] [unreadable]..
  12. ROLE OF PROTEASOMAL DYSFUNCTION IN PARKINSON'S DISEASE
    KEVIN MCNAUGHT; Fiscal Year: 2008
    ..These studies will test our hypothesis that inadequate proteasomal function underlies both vulnerability and degeneration of the SNc in sporadic Parkinson's disease. ..
  13. Genomic Characterization in Depression and Suicide.
    Etienne Sibille; Fiscal Year: 2007
    ..The training program proposes formal courses, supervised training and frequent interactions with several research groups involved in pioneering aspects of genomic research in mood disorders. [unreadable] [unreadable]..
  14. Signal Transduction in Depression
    Richard Shelton; Fiscal Year: 2008
    ..These studies may shed light on important cellular mediators of depression and provide new targets for amelioration. [unreadable] [unreadable]..
  15. Brain Development on Adults with Schizophrenia
    George Bartzokis; Fiscal Year: 2008
    ..This will change our concept of how we could treat this illness, the feasibility of changing its lifelong course, and would encourage the development of novel pharmacologic interventions to improve myelination. [unreadable] [unreadable]..
  16. The Basis of Psychotic Symptoms in Parkinson's Disease
    Deborah Mash; Fiscal Year: 2008
    ..Recent publications from our group, our preliminary results, the brain tissue availability and the multidisciplinary team assembled provide strong support for the feasibility of this project. [unreadable] [unreadable] [unreadable]..
  17. Neurology of Attention and Neglect-A Network Approach
    Marek Marsel Mesulam; Fiscal Year: 2008
    ..The results of these experiments will help to understand the neurological bases of spatial attention and may lead to more rational treatments of hemispatial neglect. ..
  18. Hibernating Myocardium and Sudden Cardiac Death
    JOHN CANTY; Fiscal Year: 2008
    ..Our long-term objective is to develop better approaches to identify patients with CAD who are most likely to benefit from primary prevention of SCD with placement of an ICD. [unreadable] [unreadable]..
  19. AD LENS PATHOLOGY: BIOCHEMISTRY & DIAGNOSTIC IMAGING
    Lee E Goldstein; Fiscal Year: 2010
    ..The resulting data may provide insights into fundamental mechanisms of AD-associated protein aeration and support development of novel AD diagnostic and monitoring technology. ..
  20. Dopamine Systems and Neuropsychiatric Changes in HIV/AIDS
    Benjamin B Gelman; Fiscal Year: 2010
    ..The project breaks ground neuroscientifically, as no autopsy study has advanced to a "task specific" behavioral correlation with circuit level anomalies of a specific neurotransmitter system. ..
  21. Biological Predictors of Response to Antidepressants
    Ramin V Parsey; Fiscal Year: 2010
    ..Our overall goal is to reduce the trial and error associated with finding an effective antidepressant by using data from pre-treatment quantification of 5-HT1A receptors and 5-HTT to guide antidepressant treatment selection. ..
  22. Metabolic Adaptation and Functional Recovery of Hibernating Myocardium
    John M Canty; Fiscal Year: 2010
    ..Our long-term objective is to use this research to develop new strategies to reverse myocardial dysfunction in patients with ischemic cardiomyoapthy which will reduce death and disability from heart failure and sudden death. ..
  23. Risk Factors and the Neurobiologic Substrate of Frailty
    Aron Buchman; Fiscal Year: 2009
    ..abstract_text> ..
  24. Tissue Engineering of Cartilage using Periosteum
    SHAWN O DRISCOLL; Fiscal Year: 2008
    ..In addition, by eliminating the need for cell culture expansion facilities and expertise, the cost of this approach should be considerably less thereby making cartilage repair more globally accessible. ..
  25. Diffusion Tensor Imaging of Wallerian Degeneration in MS
    Khader Hasan; Fiscal Year: 2009
    ..This tool will also help in the fusion of multi-modal MRI data for a robust segmentation of the subregions of CC and 1C. The DTI measures, after accounting for the age and gender dependence will be correlated with the clinical measures. ..
  26. Synaptic Apoptosis in Schizophrenia
    LEISA GLANTZ; Fiscal Year: 2008
    ..abstract_text> ..
  27. Sleep, Circadian Rhythms and Dementing Illnesses
    David Harper; Fiscal Year: 2007
    ..abstract_text> ..
  28. TEXAS REPOSITORY FOR AIDS NEUROPATHOGENESIS RESEARCH
    Benjamin Gelman; Fiscal Year: 2007
    ..abstract_text> ..
  29. Cox-2 deficient mice are resistant to MPTP neurotoxicity
    Guoying Bing; Fiscal Year: 2007
    ..abstract_text> ..
  30. MULTICENTER GENETIC STUDIES OF SCHIZOPHRENIA
    Brien Riley; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  31. Rapid Screening Method: Gamma-hydroxybutyrate Detection
    Deborah Mash; Fiscal Year: 2002
    ..Both of these methods will be tested on GHB-spiked controls and residual blood and urine specimens obtained from the Miami-Dade County Medical Examiner Department and the Emergency Department of Jackson Memorial Hospital. ..
  32. MICROGLIA ACTIVATION INDUCES PARKINSONISM IN RATS
    Guoying Bing; Fiscal Year: 2002
    ..abstract_text> ..
  33. Molecular Diagnosis Utilizing Cerebrospinal Fluid
    STEPHEN GINSBERG; Fiscal Year: 2003
    ..abstract_text> ..
  34. Auditory Cortex: Regional Pathology In Schizophrenia
    Robert Sweet; Fiscal Year: 2003
    ..abstract_text> ..
  35. Prefrontal Cell Pathology Distinguishes Mental Disorders
    Grazyna Rajkowska; Fiscal Year: 2003
    ..The proposed study will illuminate disrupted cortical circuits involved in psychotic and depressed symptomatology and possibly cortical Sites of action for antidepressant and antipsychotic medications. ..
  36. PREVALENCE AND PROGRESSION OF DM2 RISK IN MA YOUTH
    Daniel Hale; Fiscal Year: 2004
    ..abstract_text> ..
  37. MECHANICAL FACTORS IN CARTILAGE REPAIR
    SHAWN O DRISCOLL; Fiscal Year: 2004
    ..It is felt that these findings will have relevance to other important area of orthopedics, including fracture healing, and have significant potential to impact the care of patients. ..
  38. ALCOHOL, HIV, AND THE BRAIN
    Adolf Pfefferbaum; Fiscal Year: 2004
    ..Specific Aim 3: To establish cross-sectional and longitudinal within-subject relationships among nueroimaging, neuropsychological, and clinical measures. ..
  39. MYELOPATHY AND NEUROPATHY DURING CHANGING HIV BURDEN
    Benjamin Gelman; Fiscal Year: 2004
    ..Together, the studies we have proposed will provide insights concerning prevalent AIDS morbidities in the HAART era. ..
  40. Lesion Induced Synaptic Plasticity
    STEPHEN GINSBERG; Fiscal Year: 2004
    ....
  41. Characterizing MRI parameters of iron-loaded tissues
    Mark Does; Fiscal Year: 2004
    ..with computer simulations, will allow the detailed, quantitative comparison of biomagnetic and NMR data from individual animals whose tissue iron content can be determined quantitatively at the end of each experiment ..
  42. Auditory cortex asymmetry in normals and schizophrenics
    John Smiley; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  43. Imaging of Serotonin Transporters in Depression
    RAMIN PARSEY; Fiscal Year: 2005
    ..These goals will be met by a combination of didactic I course work and supervision. ..
  44. HIV and the Proteasome in the Aging Human Brain
    Benjamin Gelman; Fiscal Year: 2005
    ..The linkage between brain inflammation and altered neuronal protein turnover could lead to a unifying functional concept of dementia with application to HIV and aging both. ..
  45. Mood Disorders & Diabetes: Common Disease Mechanisms
    WILLIAM REGENOLD; Fiscal Year: 2005
    ..S. Such treatments could have the potential not only to provide symptom relief but also to repair and prevent the brain disease contributing to treatment resistance. ..
  46. Beta-glucocerebrosidase Mutations and PD in the Ashkenazim
    Lorraine Clark; Fiscal Year: 2006
    ..Significantly, recent studies suggest that mutations in the GBA gene may be associated with Parkinson's disease and the lysosomal/autophagic pathway has also been implicated in PD pathogenesis. [unreadable] [unreadable]..
  47. Calpain Inhibition Strategies for Spinal Cord Injury
    JAMES GEDDES; Fiscal Year: 2007
    ..Together, the goal of the proposed studies is to develop effective strategies for calpain inhibition following SCI. ..
  48. MOLECULAR NEUROBIOLOGY OF DEPRESSION
    Richard Shelton; Fiscal Year: 2003
    ..Develop further expertise in basic molecular biological methods; 2. Develop new projects oriented to future funding opportunities; and 3. Continue to mentor the next generation of investigators. ..
  49. Prenatal Cannabis Effect on the Endocannabinoid System
    VINOD YARAGUDRI; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  50. Microglial interactions with amyloid beta peptide
    Douglas Walker; Fiscal Year: 2003
    ..Overall, the findings from the proposed research could extend our knowledge of the inflammatory events occurring in the AD brain. ..
  51. AMYLOIDOGENIC EFFECTS OF CHOLINERGIC DENERVATION
    Thomas Beach; Fiscal Year: 2002
    ..This could lead to impaired cerebral vasoregulation and increased susceptibility to ischemia, further compromising cortical function in AD. ..
  52. Isolation and Characterization of Cholinesterases From Plaques and Tangles
    Changiz Geula; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  53. COCHLEAR MECHANICS
    WILLIAM RHODE; Fiscal Year: 2007
    ..Mechanical measurements will be compared I to auditory nerve responses in the same species and using the same signals. ..
  54. CALBINDIN AND CHOLINERGIC NEURONS IN AGING AND AD
    Changiz Geula; Fiscal Year: 2002
    ....
  55. POSITIONAL CLONING OF A PLEIOTROPIC LOCUS FOR BEHAVIOR
    Howard Gershenfeld; Fiscal Year: 2002
    ..We hypothesize that the characterization of this exq1 locus will delineate a novel mechanism for regulating behavior and neuronal excitability and may lead to a target for rational drug design. ..