death

Summary

Summary: Irreversible cessation of all bodily functions, manifested by absence of spontaneous breathing and total loss of cardiovascular and cerebral functions.

Top Publications

  1. doi Reversal of the British trends in place of death: time series analysis 2004-2010
    Barbara Gomes
    King s College London, Cicely Saunders Institute, Department of Palliative Care, Policy and Rehabilitation, London, UK
    Palliat Med 26:102-7. 2012
  2. pmc Factors influencing death at home in terminally ill patients with cancer: systematic review
    Barbara Gomes
    The Cicely Saunders Foundation Department of Palliative Care, Policy, and Rehabilitation, King s College London, London SE5 9RJ
    BMJ 332:515-21. 2006
  3. doi Hemolytic uremic syndrome and death in persons with Escherichia coli O157:H7 infection, foodborne diseases active surveillance network sites, 2000-2006
    L Hannah Gould
    Enteric Diseases Epidemiology Branch, National Center for Zoonotic, Vector Borne, and Enteric Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Clin Infect Dis 49:1480-5. 2009
  4. ncbi When death is imminent: where terminally ill patients with cancer prefer to die and why
    Siew Tzuh Tang
    National Yang Ming University, School of Nursing, 155, Sec 2 Li Nong Street, Taipei, Taiwan, Republic of China
    Cancer Nurs 26:245-51. 2003
  5. doi Between life and death: women's experiences of coming close to death, and surviving a severe postpartum haemorrhage and emergency hysterectomy
    Rakime Elmir
    Family and Community Health Research Group FaCH, School of Nursing and Midwifery, University of Western Sydney, Sydney, Penrith South DC, NSW 1797, Australia
    Midwifery 28:228-35. 2012
  6. pmc Smooth and cardiac muscle-selective knock-out of Kruppel-like factor 4 causes postnatal death and growth retardation
    Tadashi Yoshida
    Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, VA 22908, USA
    J Biol Chem 285:21175-84. 2010
  7. doi Kidney transplantation from donors after cardiac death: a 25-year experience
    Maarten G J Snoeijs
    Department of Surgery, Maastricht University Medical Center, Maastricht, The Netherlands
    Transplantation 90:1106-12. 2010
  8. pmc Aortic arch plaques and risk of recurrent stroke and death
    Marco R Di Tullio
    Division of Cardiology, Department of Medicine, Columbia University, College of Physicians and Surgeons, 630 W 168th St, New York, NY 10032, USA
    Circulation 119:2376-82. 2009
  9. ncbi The transformation of utilities for health states worse than death: consequences for the estimation of EQ-5D value sets
    Leida M Lamers
    Institute for Medical Technology Assessment Department of Health Policy and Management, Erasmus University Medical Center Rotterdam, The Netherlands
    Med Care 45:238-44. 2007
  10. doi Death toll exceeded 70,000 in Europe during the summer of 2003
    Jean Marie Robine
    INSERM, Demographie et Sante, CRLC, Centre Val d Aurelle, Parc Euromedecine, 34298 Montpellier Cedex 5, France
    C R Biol 331:171-8. 2008

Research Grants

  1. Genetic variation and regulatory networks: Mechanisms and complexity
    DANA PE ER; Fiscal Year: 2009
  2. Personalized Clinical Diagnostics and Beyond: Integrated Ring Resonator Arrays
    Ryan Bailey; Fiscal Year: 2009
  3. NIH Director's Pioneer Award
    Junying Yuan; Fiscal Year: 2009
  4. Prevention of Complications in Thalassemia
    Elliott P Vichinsky; Fiscal Year: 2011
  5. Chymase-Mediated MMP Activation in Ishemia Reperfusion Injury
    LOUIS JOSEPH DELL'ITALIA; Fiscal Year: 2013
  6. Lauren Endres; Fiscal Year: 2014
  7. Anti-tumor properties of curcumin in oral cancers: role of thioredoxin reductase
    STEPHEN WILLIAM TUTTLE; Fiscal Year: 2010
  8. Ian C Michelow; Fiscal Year: 2016
  9. James D Bryers; Fiscal Year: 2016
  10. Iron-mediated vascular disease in sickle cell disease.
    John C Wood; Fiscal Year: 2010

Detail Information

Publications467 found, 100 shown here

  1. doi Reversal of the British trends in place of death: time series analysis 2004-2010
    Barbara Gomes
    King s College London, Cicely Saunders Institute, Department of Palliative Care, Policy and Rehabilitation, London, UK
    Palliat Med 26:102-7. 2012
    ..Secular trends towards an institutionalised dying have been reported in Britain and other developed world regions...
  2. pmc Factors influencing death at home in terminally ill patients with cancer: systematic review
    Barbara Gomes
    The Cicely Saunders Foundation Department of Palliative Care, Policy, and Rehabilitation, King s College London, London SE5 9RJ
    BMJ 332:515-21. 2006
    To determine the relative influence of different factors on place of death in patients with cancer.
  3. doi Hemolytic uremic syndrome and death in persons with Escherichia coli O157:H7 infection, foodborne diseases active surveillance network sites, 2000-2006
    L Hannah Gould
    Enteric Diseases Epidemiology Branch, National Center for Zoonotic, Vector Borne, and Enteric Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Clin Infect Dis 49:1480-5. 2009
    ..We evaluated the age-specific rate of HUS and death among persons with STEC O157 infection and the risk factors associated with developing HUS.
  4. ncbi When death is imminent: where terminally ill patients with cancer prefer to die and why
    Siew Tzuh Tang
    National Yang Ming University, School of Nursing, 155, Sec 2 Li Nong Street, Taipei, Taiwan, Republic of China
    Cancer Nurs 26:245-51. 2003
    ..Scholars defined one domain of quality of dying and death as dying at the place of one's choice...
  5. doi Between life and death: women's experiences of coming close to death, and surviving a severe postpartum haemorrhage and emergency hysterectomy
    Rakime Elmir
    Family and Community Health Research Group FaCH, School of Nursing and Midwifery, University of Western Sydney, Sydney, Penrith South DC, NSW 1797, Australia
    Midwifery 28:228-35. 2012
    ..to describe women's experiences of having an emergency hysterectomy following a severe postpartum haemorrhage...
  6. pmc Smooth and cardiac muscle-selective knock-out of Kruppel-like factor 4 causes postnatal death and growth retardation
    Tadashi Yoshida
    Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, VA 22908, USA
    J Biol Chem 285:21175-84. 2010
    ..In vivo chromatin immunoprecipitation assays on the heart revealed that Klf4 bound to the promoter region of the Gata4 gene. Results provide novel evidence that Klf4 plays a key role in late fetal and/or postnatal cardiac development...
  7. doi Kidney transplantation from donors after cardiac death: a 25-year experience
    Maarten G J Snoeijs
    Department of Surgery, Maastricht University Medical Center, Maastricht, The Netherlands
    Transplantation 90:1106-12. 2010
    ..Donation after cardiac death (DCD) has been shown to increase the number of kidneys available for transplantation...
  8. pmc Aortic arch plaques and risk of recurrent stroke and death
    Marco R Di Tullio
    Division of Cardiology, Department of Medicine, Columbia University, College of Physicians and Surgeons, 630 W 168th St, New York, NY 10032, USA
    Circulation 119:2376-82. 2009
    ..Aortic arch plaques are a risk factor for ischemic stroke. Although the stroke mechanism is conceivably thromboembolic, no randomized studies have evaluated the efficacy of antithrombotic therapies in preventing recurrent events...
  9. ncbi The transformation of utilities for health states worse than death: consequences for the estimation of EQ-5D value sets
    Leida M Lamers
    Institute for Medical Technology Assessment Department of Health Policy and Management, Erasmus University Medical Center Rotterdam, The Netherlands
    Med Care 45:238-44. 2007
    Utilities for health are measured on an interval scale, where 1 refers to full health and 0 refers to death. No theoretical lower boundary on the utilities for states worse than death exists...
  10. doi Death toll exceeded 70,000 in Europe during the summer of 2003
    Jean Marie Robine
    INSERM, Demographie et Sante, CRLC, Centre Val d Aurelle, Parc Euromedecine, 34298 Montpellier Cedex 5, France
    C R Biol 331:171-8. 2008
    ..Centralizing the count of daily deaths on an operational geographical scale constitutes a priority for Public Health in Europe...
  11. pmc Birth and death of protein domains: a simple model of evolution explains power law behavior
    Georgy P Karev
    National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA
    BMC Evol Biol 2:18. 2002
    ..Exploration of different types of evolutionary models in an attempt to determine which of them lead to power law distributions has the potential of revealing non-trivial aspects of genome evolution...
  12. ncbi Why do patients choose chemotherapy near the end of life? A review of the perspective of those facing death from cancer
    Robin Matsuyama
    Massey Cancer Center of Virginia Commonwealth University, Richmond, VA 23298 0230, USA
    J Clin Oncol 24:3490-6. 2006
    ..We sought to determine the available sources of knowledge, the choices, and concerns of actual patients, and how patients balanced competing issues...
  13. doi Current situation of donation after circulatory death in European countries
    Beatriz Dominguez-Gil
    Organizacion Nacional de Trasplantes, Madrid, Spain
    Transpl Int 24:676-86. 2011
    The aim of the present study was to describe the current situation of donation after circulatory death (DCD) in the Council of Europe, through a dedicated survey...
  14. doi Pediatric heart transplantation after declaration of cardiocirculatory death
    Mark M Boucek
    Department of Pediatrics, Joe DiMaggio Children s Hospital, Hollywood, FL 33021, USA
    N Engl J Med 359:709-14. 2008
    ..The mean age of donors was 3.7 days, and the mean time to death after withdrawal from life support was 18.3 minutes...
  15. ncbi Peak oxygen consumption as a predictor of death in patients with heart failure receiving beta-blockers
    James O O'Neill
    Department of Cardiovascular Medicine, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Circulation 111:2313-8. 2005
    ..Beta-blockers reduce mortality in patients with heart failure, without influencing peak VO2, raising the possibility that peak VO2 is no longer suitable as an indicator of prognosis in these patients...
  16. pmc Effect of death-to-preservation time on donor corneal epithelium
    Woodford S Van Meter
    Department of Ophthalmology, University of Kentucky, Lexington, Kentucky, USA
    Trans Am Ophthalmol Soc 103:209-22; discussion 222-4. 2005
    ..Eye banks use death-to-preservation (DP) time intervals as long as 18 hours...
  17. doi Histidine-Tryptophan-Ketoglutarate (HTK) is associated with reduced graft survival in deceased donor livers, especially those donated after cardiac death
    Z A Stewart
    Department of Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Am J Transplant 9:286-93. 2009
    ..8% in 2004 to 26.9% in 2008; this was particularly striking among donor after cardiac death (DCD) allografts, rising from 20.7% in 2004 to 40.9% in 2008...
  18. pmc Manganese superoxide dismutase: beyond life and death
    Aaron K Holley
    University of Kentucky, Lexington, USA
    Amino Acids 42:139-58. 2012
    ..The results demonstrate the role of MnSOD beyond its essential role for survival and suggest a novel strategy for an antioxidant approach to cancer intervention...
  19. pmc Identification of markers for imminent death in mice used in longevity and aging research
    Maria A Ray
    Department of Medical Microbiology, Immunology, and Cell Biology, Southern Illinois University School of Medicine, Springfield, Illinois, USA
    J Am Assoc Lab Anim Sci 49:282-8. 2010
    The goal of this study was to identify objective criteria that would reliably predict imminent death in aged mice...
  20. doi Professional tears: developing emotional intelligence around death and dying in emergency work
    Cara Bailey
    School of Nursing, Queens Medical Centre, Nottingham, UK
    J Clin Nurs 20:3364-72. 2011
    This paper explores how emergency nurses manage the emotional impact of death and dying in emergency work and presents a model for developing expertise in end-of-life care delivery.
  21. doi A subset of circulating microRNAs are predictive for cardiac death after discharge for acute myocardial infarction
    Sen Matsumoto
    Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine, Suita, Japan
    Biochem Biophys Res Commun 427:280-4. 2012
    ..667 miRs, 11 miRs were found to be differentially expressed in the serum among patients at high-risk for cardiac death. Real-time RT-PCR confirmed that the serum levels of miR-155 and miR-380* were approximately 4- and 3-fold higher, ..
  22. doi Donation after circulatory death: current status
    Arne Neyrinck
    Division of Anesthesiology and Algology, University Hospitals Leuven, Leuven, Belgium
    Curr Opin Anaesthesiol 26:382-90. 2013
    ..Donation after circulatory death (DCD) has opened new perspectives and could be a valuable option to expand the brain-dead donors...
  23. ncbi A palliative-care intervention and death at home: a cluster randomised trial
    M S Jordhøy
    Unit of Applied Clinical Research, Norwegian University of Science and Technology, Kreftbygget, University Hospital of Trondheim
    Lancet 356:888-93. 2000
    ..We did a cluster randomised trial to assess the intervention's effectiveness compared with conventional care..
  24. ncbi The vortex: families' experiences with death in the intensive care unit
    Karin T Kirchhoff
    University of Utah College of Nursing, Salt Lake City, USA
    Am J Crit Care 11:200-9. 2002
    Lack of communication from healthcare providers contributes to the anxiety and distress reported by patients' families after a patient's death in the intensive care unit.
  25. pmc Predicting death from tumour necrosis factor-alpha and interleukin-6 in 80-year-old people
    H Bruunsgaard
    Department of Infectious Diseases, H S, Rigshospitalet, University of Copenhagen, Glostrup University Hospital, Denmark
    Clin Exp Immunol 132:24-31. 2003
    ..and effects of the two cytokines were independent of each other as well as of other traditional risk factors for death [smoking, blood pressure, physical exercise, total cholesterol, co-morbidity, body mass index (BMI) and intake of ..
  26. pmc Deterioration, death and the evolution of reproductive restraint in late life
    John M McNamara
    Department of Mathematics, University of Bristol, University Walk, Bristol BS8 1TW, UK
    Proc Biol Sci 276:4061-6. 2009
    ..It also provides a unified account of not only standard life-history models but of related models involving the allocation of limited resources...
  27. pmc The Quality of Dying and Death Questionnaire (QODD): empirical domains and theoretical perspectives
    Lois Downey
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, Harborview Medical Center, University of Washington, Seattle, Washington 98104, USA
    J Pain Symptom Manage 39:9-22. 2010
    ..in Missoula, Montana, to construct a model of latent-variable domains underlying the Quality of Dying and Death questionnaire (QODD)...
  28. doi Involvement of palliative care services strongly predicts place of death in Belgium
    Dirk Houttekier
    End of Life Care Research Group, Ghent University, Brussels, Belgium
    J Palliat Med 13:1461-8. 2010
    Place of death is considered a quality indicator of end-of-life care and enabling people to die where they choose is an important aspiration of palliative care...
  29. doi A primatological perspective on death
    James R Anderson
    Department of Psychology, University of Stirling, Scotland
    Am J Primatol 73:410-4. 2011
    ..It is argued that particular attention should be paid to how the context of a death affects individuals, for example, traumatic accidental or predation-induced death versus peaceful death following ..
  30. doi Novel approaches to expanding the lung donor pool: donation after cardiac death and ex vivo conditioning
    Marcelo Cypel
    Division Thoracic Surgery, Toronto Lung Transplant Program, Toronto General Hospital, University of Toronto, Toronto, M5G 2C4, Canada
    Clin Chest Med 32:233-44. 2011
    ..In the first approach, lungs from donation after cardiac death (DCD) donors are used to increase the quantity of organ donors...
  31. doi Donation after circulatory death: burying the dead donor rule
    David Rodríguez-Arias
    Universidad del Pais Vasco EHU
    Am J Bioeth 11:36-43. 2011
    ..regarding the vital status of both brain-dead donors and individuals who undergo donation after circulatory death (DCD), respecting the dead donor rule (DDR) remains the standard moral framework for organ procurement...
  32. doi Variability in the determination of death after cardiac arrest: a review of guidelines and statements
    Sonny Dhanani
    Pediatric Critical Care, Children s Hospital of Eastern Ontario, Faculty of Medicine, University of Ottawa, Canada
    J Intensive Care Med 27:238-52. 2012
    The reemergence of organ donation after circulatory determination of death (DCDD) in Canada demands the establishment of clear, evidence-based guidelines for the determination of death...
  33. doi Mortality in parents following the death of a child: a nationwide follow-up study from Sweden
    Mikael Rostila
    Centre for Health Equity Studies, Stockholm University, Stockholm, Sweden
    J Epidemiol Community Health 66:927-33. 2012
    The death of a young child is so devastating that it can increase the risk of mortality in the grieving parent. Little is known about the impact of an adult child's death on the health of parents.
  34. doi Combined use of high-sensitivity ST2 and NTproBNP to improve the prediction of death in heart failure
    Antoni Bayes-Genis
    Heart Failure Unit, Hospital Universitari Germans Trias i Pujol, Badalona, Spain
    Eur J Heart Fail 14:32-8. 2012
    To address the incremental usefulness of biomarkers from different disease pathways for predicting risk of death in heart failure (HF).
  35. pmc Transfusion of older stored blood and risk of death: a meta-analysis
    Dong Wang
    Critical Care Medicine Department, National Institutes of Health, Bethesda, Maryland 20892, USA
    Transfusion 52:1184-95. 2012
    ..Older blood develops lesions and accumulates potentially injurious substances. Some studies report increasing toxicity as blood ages. We assessed the safety of transfused older versus newer stored blood...
  36. doi Randomized trial of short-course high-dose erythropoietin in donation after cardiac death kidney transplant recipients
    Z Aydin
    Department of Nephrology, Leiden University Medical Center, Leiden, The Netherlands
    Am J Transplant 12:1793-800. 2012
    ..single center study with high-dose recombinant human erythropoietin-β (Epoetin) in 92 donation after cardiac death (DCD) kidney transplant recipients. Patients were randomized to receive an intravenous bolus of Epoetin (3...
  37. pmc Do good health and material circumstances protect older people from the increased risk of death after bereavement?
    Sunil M Shah
    Division of Population Health Sciences and Education, St George s University of London, London, UK
    Am J Epidemiol 176:689-98. 2012
    An increased risk of death in persons who have suffered spousal bereavement has been described in many populations. The impact of modifying factors, such as chronic disease and material circumstances, is less well understood...
  38. pmc LACE+ index: extension of a validated index to predict early death or urgent readmission after hospital discharge using administrative data
    Carl van Walraven
    Ottawa Hospital Research Institute, Administrative Services Building, Room 1003, 1053 Carling Avenue, Ottawa, ON K1Y 4E9, Canada
    Open Med 6:e80-90. 2012
    b>Death or urgent readmission after hospital discharge is a common adverse event that can be used to compare outcomes of care between institutions...
  39. ncbi Stroke in parents who lost a child: a nationwide follow-up study in Denmark
    Jiong Li
    Danish Epidemiology Science Centre, Department of Epidemiology and Social Medicine, University of Aarhus, Aarhus, Denmark
    Neuroepidemiology 22:211-6. 2003
    ..We therefore examined whether or not one of the most extreme psychological stressors, the death of a child, was associated with the risk of stroke in a nationwide population-based follow-up study...
  40. doi Death or hospitalization of patients on chronic hemodialysis is associated with a physician-based diagnosis of depression
    S Susan Hedayati
    Division of Nephrology, Department of Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    Kidney Int 74:930-6. 2008
    ..Using time to event (death or hospitalization) models of analysis the hazard ratios were 2.11 and 2...
  41. doi Review: the quality of dying and death: a systematic review of measures
    Sarah Hales
    Psychosocial Oncology and Palliative Care, Princess Margaret Hospital, University Health Network, Toronto, ON, Canada
    Palliat Med 24:127-44. 2010
    ..To determine whether modern medicine is facilitating 'good' deaths, appropriate measures of the quality of dying and death must be developed and utilized...
  42. doi There is nothing paranormal about near-death experiences: how neuroscience can explain seeing bright lights, meeting the dead, or being convinced you are one of them
    Dean Mobbs
    Medical Research Council, Cognition and Brain Sciences Unit, 15 Chaucer Road, Cambridge, CB2 7EF, UK
    Trends Cogn Sci 15:447-9. 2011
    Approximately 3% of Americans declare to have had a near-death experience...
  43. ncbi Anxiety and depression in parents 4-9 years after the loss of a child owing to a malignancy: a population-based follow-up
    Ulrika Kreicbergs
    Clinical Cancer Epidemiology, Department of Oncology and Pathology, Karolinska Institutet Z6 01, Karolinska Hospital, SE 171 76 Stockholm, Sweden
    Psychol Med 34:1431-41. 2004
    Some consider the loss of a child as the most stressful life event. When the death is caused by a malignancy, the parents are commonly exposed not only to their own loss, but also to the protracted physical and emotional suffering of the ..
  44. ncbi Excess weight at time of presentation of myocardial infarction is associated with lower initial mortality risks but higher long-term risks including recurrent re-infarction and cardiac death
    Anil Nigam
    Mayo Clinic and Mayo Foundation, Rochester, MN 55905, USA
    Int J Cardiol 110:153-9. 2006
    ..To evaluate the influence of elevated body mass index (BMI) on short- and long-term survival following acute myocardial infarction (AMI)...
  45. pmc Protein kinase Cepsilon makes the life and death decision
    Alakananda Basu
    Department of Molecular Biology and Immunology, University of North Texas Health Science Center, Fort Worth, TX 76107, USA
    Cell Signal 19:1633-42. 2007
    ..is caused by dysregulation in cellular signaling systems that control cell proliferation, differentiation and cell death. Protein kinase C (PKC), a family of serine/threonine kinases, plays an important role in the growth factor signal ..
  46. doi Ischemic cholangiopathy following liver transplantation from donation after cardiac death donors
    Edie Y Chan
    Division of Transplantation, Department of Surgery, University of Washington, Seattle, WA 98195, USA
    Liver Transpl 14:604-10. 2008
    The use of donation after cardiac death (DCD) donor hepatic allografts is becoming more widespread; however, there have been published reports of increased graft failure from specific complications associated with this type of allograft...
  47. doi DSCAM deficiency causes loss of pre-inspiratory neuron synchroneity and perinatal death
    Kenji Amano
    Laboratory for Neurogenetics, RIKEN Brain Science Institute, Wako Shi, Saitama 351 0198, Japan
    J Neurosci 29:2984-96. 2009
    ..These results suggest that DSCAM plays a critical role in central respiratory regulation in a dosage-dependent manner...
  48. pmc Epidemiological pathology of dementia: attributable-risks at death in the Medical Research Council Cognitive Function and Ageing Study
    Fiona E Matthews
    Medical Research Council MRC Biostatistics, University of Cambridge, Cambridge, United Kingdom
    PLoS Med 6:e1000180. 2009
    ..We report the attributable risks (ARs) for dementia at death for common age-related degenerative and vascular pathologies, and other factors, in the MRC Cognitive Function and ..
  49. doi Factors influencing place of death in Germany
    Luis Carlos Escobar Pinzón
    Institute of Occupational, Social and Environmental Medicine, University Medical Center of Johannes Gutenberg University of Mainz, Mainz, Germany
    J Pain Symptom Manage 41:893-903. 2011
    Knowledge about factors influencing the place of death may be very useful for the planning of public health strategies to improve the situation of terminally ill patients.
  50. doi Liver transplantation using Donation after Cardiac Death donors
    Diethard Monbaliu
    Catholic University Leuven, Department of Abdominal Transplant Surgery, University Hospitals Leuven, Leuven, Belgium
    J Hepatol 56:474-85. 2012
    ..All countries have strived to expand donor numbers beyond the standard Donation after Brain Death (DBD)...
  51. doi The effect of normothermic recirculation before cold preservation on post-transplant injury of ischemically damaged donor kidneys
    Cyril Moers
    Surgery Research Laboratory, Department of Surgery, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Transpl Int 25:210-7. 2012
    Kidneys recovered from donation after cardiac death (DCD) are increasingly used to enlarge the deceased donor pool...
  52. doi Good death inventory: a measure for evaluating good death from the bereaved family member's perspective
    Mitsunori Miyashita
    Department of Adult Nursing Palliative Care Nursing, School of Health Sciences and Nursing, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    J Pain Symptom Manage 35:486-98. 2008
    The aim of this study was to develop a measure for evaluating good death from the bereaved family member's perspective, and to examine the validity and reliability of the assessment...
  53. ncbi Serum neutrophil gelatinase-associated lipocalin as a predictor of organ recovery from delayed graft function after kidney transplantation from donors after cardiac death
    Mamoru Kusaka
    Dept of Urol, Div of Molecular Genetics, Inst for Comp Med Sci and 21st Century COE Program, Dev Center for Targeted and Minimally Invasive Diagnosis and Treatment, Fujita Health University School of Medicine, Japan
    Cell Transplant 17:129-34. 2008
    Because of a worldwide shortage of renal grafts, kidneys procured from donors after cardiac death (DCD) have recently become an important source of renal transplants...
  54. doi Surges of electroencephalogram activity at the time of death: a case series
    Lakhmir S Chawla
    Department of Critical Care Medicine and Anesthesiology, George Washington University Medical Center, Washington, DC 20037, USA
    J Palliat Med 12:1095-100. 2009
    ..increase in electrical activity occurred when there was no discernable blood pressure, patients who suffer "near death" experiences may be recalling the aggregate memory of the synaptic activity associated with this terminal but ..
  55. pmc Decapitation in rats: latency to unconsciousness and the 'wave of death'
    Clementina M Van Rijn
    Department of Biological Psychology, Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen, Nijmegen, The Netherlands
    PLoS ONE 6:e16514. 2011
    ..massive wave which can be recorded approximately one minute after decapitation reflects the ultimate border between life and death. This observation might have implications in the discussions on the appropriate time for organ donation.
  56. pmc Parental death during childhood and adult cardiovascular risk in a developing country: the Guangzhou Biobank Cohort Study
    C Mary Schooling
    Department of Community Medicine, School of Public Health, The University of Hong Kong, Hong Kong SAR, China
    PLoS ONE 6:e19675. 2011
    ..We examined the association of a potential marker of childhood emotional adversity with cardiovascular disease risk factors in a developing country...
  57. doi Pilot study on traumatic grief treatment program for Japanese women bereaved by violent death
    Nozomu Asukai
    Department of Psychiatry and Behavioral Sciences, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan
    J Trauma Stress 24:470-3. 2011
    ..Based on Jacobson's Reliable Change Index, 46% showed change on all 3 measures. These findings suggest that our treatment model may be feasible for treating traumatic grief with PTSD in non-Western settings...
  58. doi Long-term evolution of 5S ribosomal DNA seems to be driven by birth-and-death processes and selection in Ensis razor shells (Mollusca: Bivalvia)
    Joaquín Vierna
    Department of Molecular and Cell Biology, Evolutionary Biology Group GIBE, Universidade da Coruna, A Zapateira s n, La Coruña 15071, Spain
    Biochem Genet 47:635-44. 2009
    ..These results strongly suggest that the long-term evolution of Ensis 5S ribosomal DNA is driven by birth-and-death processes and selection.
  59. ncbi A longitudinal study of the effects of age and time to death on hospital costs
    Meena Seshamani
    University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    J Health Econ 23:217-35. 2004
    Recent studies indicate that approaching death, rather than age, may be the main demographic driver of health care costs...
  60. ncbi Hospitalization for mental illness among parents after the death of a child
    Jiong Li
    Danish Epidemiology Science Center, Department of Epidemiology and Social Medicine, University of Aarhus, Aarhus, Denmark
    N Engl J Med 352:1190-6. 2005
    ..The loss of a child is considered one of the most stressful events in the life of a parent. We hypothesized that parental bereavement increases the risk of hospital admission for a psychiatric disorder, especially for affective disorders...
  61. doi Risk of myocardial infarction and death associated with the use of nonsteroidal anti-inflammatory drugs (NSAIDs) among healthy individuals: a nationwide cohort study
    E L Fosbøl
    Department of Cardiology, Gentofte University Hospital, Hellerup, Denmark
    Clin Pharmacol Ther 85:190-7. 2009
    ..Using a historical cohort design, we estimated the risk of death and myocardial infarction associated with the use of NSAIDs...
  62. doi Irresistible bouquet of death--how are burying beetles (Coleoptera: Silphidae: Nicrophorus) attracted by carcasses
    B Kalinová
    Infochemicals Group, Institute of Organic Chemistry and Biochemistry v v i, Academy of Sciences of the Czech Republic, Flemingovo nam 2, 166 10, Prague 6, Czech Republic
    Naturwissenschaften 96:889-99. 2009
    ..Chemical analysis showed that immediately after death, emitted volatiles did not differ from those emitted by a living organism...
  63. ncbi Psychiatric morbidity, violent crime, and suicide among children and adolescents exposed to parental death
    Holly C Wilcox
    Johns Hopkins University, Baltimore, MD 21287 3325, USA
    J Am Acad Child Adolesc Psychiatry 49:514-23; quiz 530. 2010
    ..This retrospective cohort study examined the risk for suicide, psychiatric hospitalization, and violent criminal convictions among offspring of parents who died from suicide, accidents, and other causes...
  64. pmc Factors associated with congruence between preferred and actual place of death
    Christina L Bell
    Department of Geriatric Medicine, John A Burns School of Medicine, University of Hawaii, Honolulu, Hawaii, USA
    J Pain Symptom Manage 39:591-604. 2010
    Congruence between preferred and actual place of death may be an essential component in terminal care. Most patients prefer a home death, but many patients do not die in their preferred location...
  65. ncbi Near-death experiences and the temporal lobe
    Willoughby B Britton
    Department of Psychology, University of Arizona, Tucson, AZ 85721, USA
    Psychol Sci 15:254-8. 2004
    ..We investigated temporal lobe functioning in individuals who reported having transcendental "near-death experiences" during life-threatening events...
  66. ncbi Extracorporeal support for organ donation after cardiac death effectively expands the donor pool
    Joseph F Magliocca
    Department of Surgery, The University of Wisconsin School of Medicine, Madison WI, USA
    J Trauma 58:1095-101; discussion 1101-2. 2005
    ..normothermic, extracorporeal perfusion (ECMO) for donation of abdominal organs for transplantation after cardiac death (DCD)...
  67. ncbi Near-death experiences in cardiac arrest survivors
    Christopher C French
    Anomalistic Psychology Research Unit, Department of Psychology, Goldsmiths College, University of London, New Cross, London SE14 6NW, UK
    Prog Brain Res 150:351-67. 2005
    Near-death experiences (NDEs) have become the focus of much interest in the last 30 years or so. Such experiences can occur both when individuals are objectively near to death and also when they simply believe themselves to be...
  68. pmc Lactate dehydrogenase as a biomarker of hemolysis-associated nitric oxide resistance, priapism, leg ulceration, pulmonary hypertension, and death in patients with sickle cell disease
    Gregory J Kato
    Vascular Medicine Branch, National Heart, Lung and Blood Institute, National Institutes of Health, 10 Center Dr, MSC 1476, Bldg 10CRC, Rm 5 5140, Bethesda, MD 20892, USA
    Blood 107:2279-85. 2006
    ..was associated with a clinical subphenotype of pulmonary hypertension, leg ulceration, priapism, and risk of death in patients with sickle cell disease...
  69. pmc The fate of laterally transferred genes: life in the fast lane to adaptation or death
    Weilong Hao
    Department of Biology, McMaster University, Hamilton, Ontario, Canada L8S 4K1
    Genome Res 16:636-43. 2006
    ..Together, this implies that many of the lineage-specific insertions are lost quickly during evolution and that perhaps a few of the genes inserted by lateral transfer are niche specific...
  70. ncbi Controlling death: the false promise of advance directives
    Henry S Perkins
    Ecumenical Center for Religion and Health and Division of General Medicine, Department of Medicine, The University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229 3900, USA
    Ann Intern Med 147:51-7. 2007
    ....
  71. ncbi Incidence and correlates of near-death experiences in a cardiac care unit
    Bruce Greyson
    Department of Psychiatric Medicine, University of Virginia Health System, Charlottesville, VA, USA
    Gen Hosp Psychiatry 25:269-76. 2003
    Near-death experiences, unusual experiences during a close brush with death, may precipitate pervasive attitudinal and behavior changes...
  72. ncbi Transforming self-rated health and the SF-36 scales to include death and improve interpretability
    P Diehr
    Department of Biostatistics, University of Washington, Seattle, Washington 98195-7232, USA
    Med Care 39:670-80. 2001
    ..EVGGFP) and the physical component score of the SF-36 (PCS) to new variables that include a defensible value for death. METHODS: Using longitudinal data from two large studies of older adults, health variables were transformed to the ..
  73. pmc Trends in the place of death of cancer patients, 1992-1997
    Frederick Burge
    Department of Family Medicine, Dalhousie University, Halifax, NS
    CMAJ 168:265-70. 2003
    ..We carried out a study to describe the yearly trends in the place of death between 1992 and 1997 and to determine predictors of out-of-hospital death for adults with cancer in Nova Scotia.
  74. pmc The accuracy of histological assessments of dental development and age at death
    T M Smith
    Department of Anthropology, Stony Brook University, USA
    J Anat 208:125-38. 2006
    ..Using known-period incremental features, the crown formation time and age at death of five pig-tailed macaques (Macaca nemestrina) were estimated with standard histological techniques and compared ..
  75. doi Prediction of cardiac death in hemodialysis patients by myocardial fatty acid imaging
    Masato Nishimura
    Cardiovascular Division, Toujinkai Hospital, Kyoto, Japan
    J Am Coll Cardiol 51:139-45. 2008
    The aim was to evaluate the potential of single-photon emission computed tomography (SPECT) to predict cardiac death in chronic hemodialysis patients using the iodinated fatty acid analogue iodine-123 123I-beta-methyl iodophenyl-..
  76. doi The boundaries of organ donation after circulatory death
    James L Bernat
    Dartmouth Medical School, Hanover, NH, USA
    N Engl J Med 359:669-71. 2008
  77. doi ASTS recommended practice guidelines for controlled donation after cardiac death organ procurement and transplantation
    D J Reich
    Drexel University College of Medicine, Philadelphia, PA, USA
    Am J Transplant 9:2004-11. 2009
    ..Controlled donation after cardiac death (DCD) offers the family and the patient with a hopeless prognosis the option to donate when brain death criteria ..
  78. doi Spectral energy of ECG morphologic differences to predict death
    Zeeshan Syed
    Department of Electrical Engineering and Computer Science, MIT, Cambridge, MA 02139 4307, USA
    Cardiovasc Eng 9:18-26. 2009
    ..We show that variations in electrocardiographic activity associated with death can be distinguished by their spectral characteristics...
  79. doi Analysis of factors that affect outcome after transplantation of kidneys donated after cardiac death in the UK: a cohort study
    Dominic M Summers
    Department of Surgery, School of Clinical Medicine, University of Cambridge, Cambridge, UK
    Lancet 376:1303-11. 2010
    A third of all kidneys from deceased donors in the UK are donated after cardiac death, but concerns have been raised about the long-term outcome of such transplants...
  80. doi The contribution of age and time-to-death on health care expenditure for out-of-hospital services
    Rachael Moorin
    Centre for Population Health Research, Curtin Health Innovation Research Institute, Curtin University, Perth, Western Australia, Australia
    J Health Serv Res Policy 17:197-205. 2012
    Controversy persists over the relationships between health care expenditure, time-to-death and age, undermining attempts to generate convincing predictions for policy...
  81. ncbi [Place of death: "Where do people die in Switzerland nowadays?"]
    S Fischer
    Universitat Zurich, Institut für Sozial und Präventivmedizin, Sumatrastr 30, 8006 Zurich, Switzerland
    Z Gerontol Geriatr 37:467-74. 2004
    Official information on the place of death has not been collected by the Swiss Federal Office of Statistics since 1987. Thus, no statements can be made for the developments in Switzerland.
  82. ncbi Change in cognitive capabilities in the oldest old: the effects of proximity to death in genetically related individuals over a 6-year period
    Boo Johansson
    Department of Psychology, University of Goteborg, Goteborg, Sweden
    Psychol Aging 19:145-56. 2004
    ..Latent growth models (LGMs) show that chronological age and time to death are consistent predictors of decline in measures of memory, reasoning, speed, and verbal abilities...
  83. pmc Existential neuroscience: a functional magnetic resonance imaging investigation of neural responses to reminders of one's mortality
    Markus Quirin
    Department of Psychology, Universitat Osnabruck, Seminarstrasse 20, 49069 Osnabruck, Germany
    Soc Cogn Affect Neurosci 7:193-8. 2012
    ..However, extant research has yet to examine the neurological correlates of cognitions about one's inevitable death. The present study thus investigated in 17 male participants patterns of neural activation elicited by mortality ..
  84. doi International perspective on the diagnosis of death
    D Gardiner
    Adult Intensive Care, Nottingham University Hospitals NHS Trust, Derby Road, Nottingham NG7 2UH, UK
    Br J Anaesth 108:i14-28. 2012
    There is growing medical consensus in a unifying concept of human death. All human death involves the irreversible loss of the capacity for consciousness, combined with the irreversible loss of the capacity to breathe...
  85. doi Temporal evolution of clinical parameters before death in dialysis patients: a new concept
    Peter Kotanko
    Renal Research Institute, New York, N Y 10128, USA
    Blood Purif 27:38-47. 2009
    ..Little is known on the dynamics of key clinical and laboratory variables in the weeks and months preceding death. In order to gain more insight into events preceding death, we embarked on a novel methodological approach which ..
  86. pmc Association of hospice patients' income and care level with place of death
    Joshua S Barclay
    Division of General Internal Medicine, Geriatrics, and Palliative Care, Department of Medicine, University of Virginia, PO Box 800909, Charlottesville, VA 22903, USA
    JAMA Intern Med 173:450-6. 2013
    ..Terminally ill patients with lower incomes are less likely to die at home, even with hospice care...
  87. ncbi "Death" and the valuation of health-related quality of life
    S Macran
    Center for Health Economics, University of York, Helsington, York, United Kingdom
    Med Care 39:217-27. 2001
    ....
  88. pmc The use of a cytokine panel to define the long-term risk stratification of heart failure/death in patients presenting with chest pain to the emergency department
    Peter A Kavsak
    Department of Pathology and Molecular Medicine, McMaster University, Hamilton, ON, Canada
    Clin Biochem 43:505-7. 2010
    To determine if a cytokine panel could be informative regarding subsequent heart failure(HF)/death.
  89. doi Propensity for home death among Taiwanese cancer decedents in 2001-2006, determined by services received at end of life
    Siew Tzuh Tang
    Graduate School of Nursing, Chang Gung University, Tao Yuan, Taiwan
    J Pain Symptom Manage 40:566-74. 2010
    The discrepancy between patients' preferred and actual place of death highlights the dilemma inherent in achieving their preferences for home death...
  90. ncbi Abandon the dead donor rule or change the definition of death?
    Robert M Veatch
    Kennedy Institute of Ethics, Georgetown University, Washington, DC, USA
    Kennedy Inst Ethics J 14:261-76. 2004
    ..Another strategy would be to further amend the definition of death to classify one or both groups as deceased, thus permitting procurement without violation of the dead donor rule...
  91. ncbi Ethnic differences in the place of death of elderly hospice enrollees
    Kimberly S Johnson
    Department of Medicine, Duke University, Durham, North Carolina, USA
    J Am Geriatr Soc 53:2209-15. 2005
    ..It is not known whether this difference is due to cultural preferences for place of death or decreased access to hospice...
  92. ncbi Factors affecting place of death in Western Australia
    Beverley McNamara
    School of Social and Cultural Studies, The University of Western Australia, 35 Stirling Highway, Crawley, Perth 6009, Australia
    Health Place 13:356-67. 2007
    Despite the growing international interest in place of death and its relationship to healthcare policy, virtually nothing is known about where people die in Australia...
  93. ncbi Preparing caregivers for the death of a loved one: a theoretical framework and suggestions for future research
    Randy S Hebert
    Division of General Internal Medicine, Section of Palliative Care and Medical Ethics, University of Pittsburgh School of Medicine, Pennsylvania 15213, USA
    J Palliat Med 9:1164-71. 2006
    Caring for a terminally ill loved one and the death of that person are two of the most stressful human experiences...
  94. doi The quality of dying and death
    Sarah Hales
    Department of Psychosocial Oncology and Palliative Care, Princess Margaret Hospital, University Health Network, Toronto, Ontario, Canada
    Arch Intern Med 168:912-8. 2008
    During the past decade, research has examined definitions and conceptualizations of quality of dying and death in different populations...
  95. doi Nuclear roundness variance predicts prostate cancer progression, metastasis, and death: A prospective evaluation with up to 25 years of follow-up after radical prostatectomy
    Robert W Veltri
    James Buchanan Brady Urological Institute, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    Prostate 70:1333-9. 2010
    ..Therefore, we evaluated the prognostic value of nuclear roundness variance (NRV) for prostate cancer (PCa) progression, metastasis and PCa-specific death free survivals in a cohort of 116 men after radical prostatectomy (RP).
  96. pmc Where do you want to spend your last days of life? Low concordance between preferred and actual site of death among hospitalized adults
    Stacy Fischer
    Division of General Internal Medicine, University of Colorado Denver School of Medicine, Denver, Colorado 80045, USA
    J Hosp Med 8:178-83. 2013
    b>Death in the U.S. frequently occurs in institutions despite the overwhelming majority of persons who state that they prefer to die at home...
  97. ncbi Effect of orally administered guanosine on seizures and death induced by glutamatergic agents
    D R Lara
    Department of Biochemistry, ICBS, Federal University of Rio Grande do Sul, Avenida Ramiro Barcelos, 2600-Anexo, CEP 90035-003, RS, Porto Alegre, Brazil
    Brain Res 912:176-80. 2001
    ..was ineffective against kainate-induced seizures, but significantly reversed the potentiation of seizures and death caused by the concomitant injection of MK-801...
  98. ncbi Electrocardiographic activity after terminal cardiac arrest in neurocatastrophes
    Eelco F M Wijdicks
    Neurological Neurosurgical Intensive Care Units at Saint Mary s Hospital, Mayo Clinic, Rochester, MN 55905, USA
    Neurology 62:673-4. 2004
  99. ncbi A good death
    Brigitte C Beuks
    Intensive and Respiratory Care, Department of Internal Medicine, University Medical Centre Groningen, University of Groningen, 30 001, 9700 RB, Groningen, The Netherlands
    Intensive Care Med 32:752-3. 2006
    ..Taking measures to ensure a "good deathbed" is an obligation for doctors and nursing staff. However, due to the focus on cure this palliative goal is not always pursued...
  100. ncbi Caloric restriction prevents radiation-induced myeloid leukemia in C3H/HeMs mice and inversely increases incidence of tumor-free death: implications in changes in number of hemopoietic progenitor cells
    Kazuko Yoshida
    Radiation Hazards Research Group, National Institute of Radiological Sciences, Chiba, Japan
    Exp Hematol 34:274-83. 2006
    ..In this report, CalR before and after irradiation was examined to determine whether they exert different effects on the prevention of radiation-induced myeloid leukemogenesis and the consequent extension of life span by CalR...
  101. doi Understanding the antecedents of the acceptance of donation after cardiac death by healthcare professionals
    Anthony M D'Alessandro
    University of Wisconsin School Medicine and Public Health, Madison, WI, USA
    Crit Care Med 36:1075-81. 2008
    ..identify potential barriers to and opportunities for increasing the number hospitals with donation after cardiac death (DCD) protocols, the support of DCD by individuals involved in the donation request process, and the number DCD ..

Research Grants81

  1. Genetic variation and regulatory networks: Mechanisms and complexity
    DANA PE ER; Fiscal Year: 2009
    ..These tools will be made publicly available, including a friendly graphical user interface and visualization. ..
  2. Personalized Clinical Diagnostics and Beyond: Integrated Ring Resonator Arrays
    Ryan Bailey; Fiscal Year: 2009
    ..This technology promises to broadly impact the landscape of the biomedical sciences, both meeting the clinical diagnostic challenges of today and pioneering the paradigm-shifting discoveries of tomorrow. ..
  3. NIH Director's Pioneer Award
    Junying Yuan; Fiscal Year: 2009
    ..No Abstract provided ..
  4. Prevention of Complications in Thalassemia
    Elliott P Vichinsky; Fiscal Year: 2011
    ..and underpin the programs to be implemented under this new project Infections are the second most common cause of death in thalassemia major...
  5. Chymase-Mediated MMP Activation in Ishemia Reperfusion Injury
    LOUIS JOSEPH DELL'ITALIA; Fiscal Year: 2013
    ..The injury culminates in the death of cardiomyocytes that were viable immediately before myocardial reperfusion and occurs despite timely reperfusion ..
  6. Lauren Endres; Fiscal Year: 2014
    ..If left unrepaired, these DNA lesions can result in cell death or mutations...
  7. Anti-tumor properties of curcumin in oral cancers: role of thioredoxin reductase
    STEPHEN WILLIAM TUTTLE; Fiscal Year: 2010
    ..reductase 1 (TxRd1), is an essential selenoprotein with defined roles in redox regulation of cell growth, death (apoptosis), transcription, DNA repair, and angiogenesis...
  8. Ian C Michelow; Fiscal Year: 2016
    ..malaria, but that are not recognized by IgG antibodies from mothers whose infants suffered severe disease or death due to malaria. Dr...
  9. James D Bryers; Fiscal Year: 2016
    ..Nosocomial infections are the fourth leading cause of death in the U.S. with >2 million cases annually (or ~10% of American hospital patients)...
  10. Iron-mediated vascular disease in sickle cell disease.
    John C Wood; Fiscal Year: 2010
    ..endocrine glands and other tissues results in severe oxidant damage, organ failure, malignant transformation and death, if unrecognized and untreated...
  11. Ligand Directed Transdermal siRNA Delivery to Improve Wound Healing
    David M Evans; Fiscal Year: 2012
    ..large portions of the skin as a result of wounds and wound-related infection may lead to major disability or even death. Every year in the United States more than 1.25 million people suffer burns and 6...
  12. Multi-targeted Countermeasures against Acute and Delayed Effects of OP Exposure
    John A Butera; Fiscal Year: 2013
    ..seizures, paralysis, mucous secretions, eye irritation, cardiorespiratory depression, GI distress, and eventually, death. Additionally, OP exposure initiates a sequelae of mechanisms leading to delayed neurodegeneration in the CNS;..
  13. Prevention of Acute Lung Injury by IL-6 activated STAT3
    Ana Moran; Fiscal Year: 2010
    Trauma is accompanied frequently by hemorrhagic shock and is the leading cause of death for those under 45 years old in the United States...
  14. Prostate, Lung, Colorectal and Ovarian (PLCO) Screening Trial
    BARBARA O'BRIEN; Fiscal Year: 2013
    ..Both screened and control participants are to be followed for at least 13 years from randomization for cancer and death ascertainment to determine if the screening regimen results in reduced disease-specific mortality...
  15. Prostate, Lung, Colorectal and Ovarian (PLCO) Screening Trial
    Mona Fouad; Fiscal Year: 2013
    ..Both screened and control participants are to be followed for at least 13 years from randomization for cancer and death ascertainment to determine if the screening regimen results in reduced disease-specific mortality...
  16. Novel Mitochondrial Mechanisms of Ethanol-Induced Cardiac Injury in Aged Females
    DONNA HOPE KORZICK; Fiscal Year: 2010
    ..Of particular interest are adaptive changes in proteins associated with metabolism, oxidative stress, and cell death. Specific aims are as follows: 1) chronic ethanol ingestion will exacerbate age-related increases in I/R injury in ..
  17. Bandana Chatterjee; Fiscal Year: 2016
    ..cancer is a major health concern among elderly men, and metastatic prostate cancer is a leading cause of cancer death in men in the USA, second only to death from lung cancer. Risk for the disease rises from the 5th decade of life...
  18. Development of a Nonpsychotropic Cannabinoid Agonist for the Treatment of Sclerod
    Robert B Zurier; Fiscal Year: 2012
    ..to organ dysfunction including debilitating esophageal dysfunction and pulmonary fibrosis, the leading cause of death for SSc patients...
  19. Patrice G Guyenet; Fiscal Year: 2015
    ..such as obstructive sleep apnea (OSA), the treatment of pain with opiates, central sleep apnea, sudden infant death syndrome (SIDS), and rare diseases such as congenital central hypoventilation syndrome (CCHS)...
  20. Merrill D Benson; Fiscal Year: 2014
    ..by the extracellular deposition of protein fibrils which disrupts normal organ function and usually leads to death from renal, hepatic or cardiac failure...
  21. Soluble Epoxide Hydrolase as a Target for Ischemic Cardioprotection
    Donna M Van Winkle; Fiscal Year: 2012
    ..triphenyltetrazolium staining, cardiac function with a left ventricular conductance catheter, and in vitro cell death by propidium iodide uptake. Measurement of EETs will be performed by liquid chromatography/mass spectrometry...
  22. BRIAN JAMES MCMAHON; Fiscal Year: 2016
    ..B virus (HBV) can cause chronic infection, resulting in cirrhosis of the liver, liver cancer, liver failure, and death.[4] [5] Much like the hepatitis A vaccine, hepatitis B immunization strategies for infants, children, adolescents ..
  23. Pathogenesis and Treatment of Liver Disease in Transaldolase Deficiency
    Andras Perl; Fiscal Year: 2013
    ..HCC was the leading cause of death in both TAL+/- (39/229;17%) and TAL-/- mice (45/97;46%) as compared to TAL+/+ littermates (1/102;1%)...
  24. Charles W Wilkinson; Fiscal Year: 2016
    ..Although termed "mild" in comparison to brain injuries resulting in death, coma, or paralysis, mTBI, particularly repetitive mTBI characteristic of soldiers deployed to Operation Iraqi ..
  25. Agrin/alpha 3 Na,K-ATPase signaling at the neuromuscular junction
    Martin A Smith; Fiscal Year: 2012
    ..lateral sclerosis, toxins such as botulinum toxin, or traumatic injury, results in muscle weakness and even death. Thus, understanding the mechanisms responsible for the formation and maintenance of the neuromuscular junction ..
  26. Randal J Kaufman; Fiscal Year: 2014
    ..Aim 3, How do eIF2a phosphorylation and CHOP expression prevent cell death? We will evaluate the role of ATF4 in cell death and screen for genes that regulate ER stress induced cell death...
  27. Neil W Kowall; Fiscal Year: 2014
    ..Despite this, the cause of motor neuron death is unknown and the role of mutant SOD1 in the generation of oxidative stress in ALS has not been established...
  28. Impact of the P479L Variant in CPT1A on Infant Mortality in Alaska
    David M Koeller; Fiscal Year: 2011
    ..Like other disorders of fatty acid oxidation, CPT1A deficiency can lead to sudden infant death. Preliminary evidence indicates that 26% of all Alaska Native infants are homozygous for the c...
  29. Inhibition of human neutrophil function by Francisella tularensis
    Lee Ann H Allen; Fiscal Year: 2012
    ..Indeed, inhalation of as few as ten organisms is sufficient to cause severe pneumonic disease, tissue necrosis and death. Because of its extreme virulence via the aerosol route, Ft is a potential bioweapon and has been classified as a ..
  30. Sphingolipid Metabolism in Drosophila Development
    Julie D Saba; Fiscal Year: 2013
    ..underlies many human disease states including neurodegenerative diseases, cardiomyopathies, cancer, programmed cell death, and bacterial and viral infections. Thus, our research plan has potentially broad translational significance.
  31. Enterococcus faecalis, Colorectal Cancer, and Bystander Effects
    Mark M Huycke; Fiscal Year: 2012
    ..Sporadic colorectal cancer is a leading cause of cancer and cancer death worldwide. These tumors are believed to arise, in part, because of bacteria in the colon...
  32. Translational Machinery in Stress Signaling and Tumor Suppression
    THOMAS J contact BEGLEY; Fiscal Year: 2010
    ..such as endoplasmic reticulum (ER) stress, can arrest cell growth and promote the repair of damage or promote cell death. Similarly, translational regulation has recently been associated with the DNA damage response, and appears to ..
  33. Targeting Inflammation for the Amelioration of Cisplatin-Hearing Loss
    Vickram Ramkumar; Fiscal Year: 2011
    ..Other treatment approaches target proteins involved in apoptosis which contribute to death of outer hair cells (OHCs)...
  34. Investigating Mechanism of Intracellular Rotational Transport with Optical T
    Jeffrey N Anker; Fiscal Year: 2012
    ..and the depletion of antioxidants, cause global cytoskeletal damage and dysfunction, DNA damage, and cell death. We will test this hypothesis by studying the effect of nanoparticle composition on the motion and transport of ..
  35. Genetic and physiological causes of inherited Vascular and Metabolic Diseases
    Arya Mani; Fiscal Year: 2013
    ..PUBLIC HEALTH RELEVANCE: Coronary artery disease (CAD) and its consequences are the single largest cause of death in the United States. CAD risk factors include high blood pressure, high cholesterol and diabetes...
  36. Collagen X and heparan sulfate proteoglycan in the hematopoietic stem cell niche.
    ELIZABETH G SWEENEY; Fiscal Year: 2012
    ..modification, transcriptional regulation of differentiation, growth hormones, respiration, cell cycle, cell death, spermatogenesis, obesity, stress, immunology, eye development, and dinosaur paleobiology...
  37. Terence S Dermody; Fiscal Year: 2015
    ..Targets of reovirus infection in vivo will be monitored for apoptotic cell death following inoculation with wild-type and als-mutant viruses to define the function of a1s- induced apoptosis in ..
  38. Insulin Signaling and the Heart in Diabetes
    EVAN DALE ABEL; Fiscal Year: 2011
    ..PUBLIC HEALTH RELEVANCE: Heart disease remains the leading cause of death in individuals with diabetes...
  39. Retinoid Metabolism and Alcohol Induced Disease
    William S Blaner; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Estimates of death rates caused by chronic alcohol consumption, published in 2004 by the World Health Organization, indicate that alcohol accounts for approximately 1.8 million deaths per year...
  40. Maria Diakonova; Fiscal Year: 2014
    ..in breast cancer, the leading type of cancer in women and the second leading cause (after lung cancer) of cancer death among women. In 2008, 40,480 women are expected to die from breast cancer in the U.S...
  41. Junxuan Lu; Fiscal Year: 2014
    ..beta-D-glucose (PGG) for the chemoprevention of prostate cancer (PCa), the number 2 cause of cancer death in US men...
  42. Shervin Assassi; Fiscal Year: 2014
    ..Pulmonary involvement is the primary cause of SSc-related death. Sequential measurements of pulmonary function in patients with SSc have shown remarkable variability in the ..
  43. ANIL KUMAR JAISWAL; Fiscal Year: 2014
    ..interaction with PGAM5/BclXL/Bcl2, HSP90, and pICln and its significance in cellular protection and cell survival/death. The domain deletion, transfection, immunoprecipitation, Western analysis, reporter and apoptosis assays will be ..
  44. Combination drug treatment to inhibit multiple cell death pathways after TBI
    ALAN IRA FADEN; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): This application entitled "Attenuation of Diverse Cell Death Pathways after Traumatic Brain Injury by Multi- drug Combination Therapy" addresses Broad Challenge Area (15): Translational Science and ..
  45. Novel PET imaging agents for early diagnosis of plaque deposition in Alzheimer's
    Padmakar Kulkarni; Fiscal Year: 2010
    ..Such developments would be a huge breakthrough for a disease that has no cure and can only be diagnosed after death when a patients'brain is autopsied...
  46. Community Participation Research of Breastfeeding Disparities in African American
    Tamar Ringel Kulka; Fiscal Year: 2009
    ..episodes, type I and type II diabetes, episodes of infant diarrhea, and incidents of childhood leukemia and sudden death syndrome...
  47. Inhibition of IkK to treat lethal Graft-vs.-Host Disease
    Patrick Flood; Fiscal Year: 2009
    ..bone marrow or stem cell transplant from a perfectly matched donor and can cause multiple complications including death of the recipient...
  48. DHAN V KALVAKOLANU; Fiscal Year: 2014
    ..One of them is the death associated protein kinase1 (DAPK1), an important regulator of apoptosis, cell cycle, and metastasis...
  49. Enzymatic Regulation of S-Glutathionylation : Role in Apoptosis and Disease
    John J Mieyal; Fiscal Year: 2012
    ..factor in PD, is likely to perturb natural redox signaling and promote inflammatory responses and apoptotic cell death. Recent studies in the laboratory of the Principal Investigator have revealed that treatment of human dopaminergic ..
  50. TLR4 Inhibition to Reduce Cerebral Ischemia Reperfusion Injury
    LORI ANN HOLLE; Fiscal Year: 2011
    ..due to embolic stroke, inflammation and edema due to IRI is responsible for a large amount of neuronal cell death in the penumbrum, a large zone around the infarcted area...
  51. Junichi Sadoshima; Fiscal Year: 2016
    ..Glycogen synthase kinase-3 (GSK-3), a serine/threonine kinase, plays an important role in regulating growth and death of cardiomyocytes...
  52. Masayuki Yazawa; Fiscal Year: 2015
    ..manifestation of repolarization in ventricular myocytes, is a major cause of cardiac arrhythmia and sudden death. Long QT syndrome (LQTS) can have a genetic basis or be induced by drug exposure or physiological stress...
  53. Rinn Song; Fiscal Year: 2016
    ..Despite the substantial global burden of pediatric TB and the higher risk of severe disease and death among young children than adults, childhood TB has been relatively neglected...
  54. Model of Timothy Syndrome to Screen Drugs with Induced Pluripotent Stem Cells
    Masayuki Yazawa; Fiscal Year: 2013
    ..manifestation of repolarization in ventricular myocytes, is a major cause of cardiac arrhythmia and sudden death. Long QT syndrome (LQTS) can have a genetic basis or be induced by drug exposure or physiological stress...
  55. Protein Nitration in the Placenta
    Leslie Myatt; Fiscal Year: 2012
    ..7% of pregnancies and being the leading cause of fetal growth restriction, indicated preterm delivery and maternal death particularly with early onset severe disease...
  56. A MicroRNA Approach to Screen for Sporadic Colon Cancer Exfoliately in Human Stoo
    Farid E Ahmed; Fiscal Year: 2010
    ..CRC is the third leading cause of cancer death among white, African American, Asian/Pacific Islander and Indian/Alaska Native men, but second among Hispanic men ..
  57. Susan L Deutscher; Fiscal Year: 2016
    DESCRIPTION (provided by applicant): Cancer is the second leading cause of death in the United States and US Veterans. Over 28% of cancer diagnoses in US Veterans in 2009 were for prostate, breast, and ovarian carcinoma...
  58. Lai Hua Xie; Fiscal Year: 2015
    DESCRIPTION (provided by applicant): Sudden cardiac death (SCD) caused by severe arrhythmias such as ventricular tachycardia (VT) and ventricular fibrillation (VF), claims the lives of 300,000-400,000 Americans annually...
  59. Arcuate nucleus glutamatergic neurons modulate energy homeostasis
    Anthony N van den Pol; Fiscal Year: 2013
    ..and the resultant increase in heart disease, hypertension, diabetes, joint dysfunction, stroke, cancer, and early death that is estimated to cost upwards of 75 billion dollars per year...
  60. John H Postlethwait; Fiscal Year: 2016
    ..Preliminary experiments show excess cell death in homozygous mutant juvenile gonads and suggest the hypothesis that 1) environmental and genetic factors affect ..
  61. MARK L DELL'ACQUA; Fiscal Year: 2016
    ..also have relevance for understanding how excessive glutamate receptor activation leads to excitotoxic neuronal death in neurodegenerative diseases, brain injury and stroke...
  62. DANIEL J CARR; Fiscal Year: 2015
    ..in the industrialized world, and frank sporadic encephalitis, a rare but debilitating disease that can result in death. Resistance to infection includes the innate immune system...
  63. Extracorporeal Support for Emergent (Uncontrolled) Donation Following Cardiac Dea
    Shawn J Pelletier; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Extracorporeal Support for Emergent (Uncontrolled) Donation Following Cardiac Death Introduction: The limited availability of donor organs for transplantation has led to an increased interest in the ..
  64. Significance of Caspase-Mediated Cleavage of PARP-1 in Cell Death
    KAREN DAVID; Fiscal Year: 2007
    unreadable] DESCRIPTION (provided by applicant): Significance of Caspase-Mediated Cleavage of PARP-1 in Cell Death Poly (ADP-ribose) polymerase-1 (PARP-1) maintains cell function by facilitating DNA repair...
  65. Systematic analysis of cell death regulation in mosquitoes
    Lei Zhou; Fiscal Year: 2009
    Title: Systematic analysis of cell death regulation in mosquitoes. Cell death (apoptosis) is an important component of the vector/host immuno-response mechanism...
  66. Innate Immune Mechanisms of Motor Neuron Injury
    Timothy Vartanian; Fiscal Year: 2010
    ..Relatedness: A central question in neurodegenerative diseases is how specific populations of neurons undergo cell death. Selective degeneration of motor neurons occurs in the setting of diverse insults including RNA viruses such as ..
  67. Vascular smooth muscle apoptosis prevention by glucose
    Frank Brosius; Fiscal Year: 2005
    ..It is therefore not surprising that modulation of these processes affects cell death pathways...
  68. ICE FAMILY AND NEURONAL CELL DEATH
    Junying Yuan; Fiscal Year: 1999
    ..In the nematode C. elegans the gene ced -3 is essential for cells to undergo programmed cell death. Interleukin-1b converting enzyme (ICE) has been identified as a vertebrate homologue of Ced-3...
  69. Connexins in Ischemia-Induced Neuronal Death
    Michael Bennett; Fiscal Year: 2007
    ..The molecular mechanisms underlying this pattern of neuronal death are not well understood...
  70. PSYCHOSOCIAL FACTORS IN SUDDEN CARDIAC DEATH
    Sue Thomas; Fiscal Year: 2002
    This proposal "Psychosocial Factor Outcome Study in Sudden Cardiac Death (PFOS)" constitutes an independent project complimentary to the ongoing NIH clinical trial, "Sudden Cardiac Death Heart Failure Trial (SCD-HeFT)...
  71. Red Blood Cell Omega-3 Fatty Acids and Coronary Artery Disease
    Luc Djousse; Fiscal Year: 2010
    ..Some observational studies and randomized trials have suggested that n-3 FA may lower the risk of sudden cardiac death (SCD) and coronary events, possibly through antiarrhythmic effects...
  72. Genes That Regulate Neuronal Cell Death
    Robert Freeman; Fiscal Year: 2009
    Cell death is widespread during the development of the nervous system where it helps to ensure that the proper number and types of connections are formed between neurons and their targets...
  73. A Novel Cell Death Pathway Induced by Galectin-1
    Linda Baum; Fiscal Year: 2004
    Cell death is a critical regulatory process in development, in homeostasis, and in disease. Many cell death triggers have been identified, although little is known about many of the molecular pathways that lead to cell death...