chromosome inversion

Summary

Summary: An aberration in which a chromosomal segment is deleted and reinserted in the same place but turned 180 degrees from its original orientation, so that the gene sequence for the segment is reversed with respect to that of the rest of the chromosome.

Top Publications

  1. pmc Chromosomal inversions and the reproductive isolation of species
    M A Noor
    Department of Biological Sciences, Life Sciences Building, Louisiana State University, Baton Rouge, LA 70803, USA
    Proc Natl Acad Sci U S A 98:12084-8. 2001
  2. ncbi The genome sequence of the malaria mosquito Anopheles gambiae
    Robert A Holt
    Celera Genomics, 45 West Gude Drive, Rockville, MD 20850, USA
    Science 298:129-49. 2002
  3. pmc Ecological niche partitioning between Anopheles gambiae molecular forms in Cameroon: the ecological side of speciation
    Frederic Simard
    Laboratoire de Lutte contre les Insectes Nuisibles, Institut de Recherche pour le Developpement, UR016, 911 Av Agropolis, Cedex 5, Montpellier, France
    BMC Ecol 9:17. 2009
  4. ncbi Extensive rearrangements in the chloroplast genome of Trachelium caeruleum are associated with repeats and tRNA genes
    Rosemarie C Haberle
    Section of Integrative Biology and Institute of Cellular and Molecular Biology, University of Texas, Austin, TX 78712, USA
    J Mol Evol 66:350-61. 2008
  5. pmc Chromosome inversions, local adaptation and speciation
    Mark Kirkpatrick
    Section of Integrative Biology, University of Texas, Austin 78712, USA
    Genetics 173:419-34. 2006
  6. pmc Ecological genomics of Anopheles gambiae along a latitudinal cline: a population-resequencing approach
    Changde Cheng
    Eck Institute for Global Health, Department of Biological Sciences, University of Notre Dame, Notre Dame, Indiana 46556, USA
    Genetics 190:1417-32. 2012
  7. pmc Paired-end mapping reveals extensive structural variation in the human genome
    Jan O Korbel
    Molecular Biophysics and Biochemistry Department, Yale University, New Haven, CT 06520, USA
    Science 318:420-6. 2007
  8. ncbi Chromosomal speciation and molecular divergence--accelerated evolution in rearranged chromosomes
    Arcadi Navarro
    Departament de Ciencies Experimentals i de la Salut, Universitat Pompeu Fabra, Doctor Aiguader 80, 08003 Barcelona, Catalonia, Spain
    Science 300:321-4. 2003
  9. pmc Nucleotide, cytogenetic and expression impact of the human chromosome 8p23.1 inversion polymorphism
    Nina Bosch
    Genetic Causes of Disease Group, Genes and Disease Programme Center for Genomic Regulation CRG UPF, Barcelona, Catalonia, Spain
    PLoS ONE 4:e8269. 2009
  10. ncbi Extensive DNA inversions in the B. fragilis genome control variable gene expression
    Ana M Cerdeño-Tárraga
    Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SA, UK
    Science 307:1463-5. 2005

Detail Information

Publications254 found, 100 shown here

  1. pmc Chromosomal inversions and the reproductive isolation of species
    M A Noor
    Department of Biological Sciences, Life Sciences Building, Louisiana State University, Baton Rouge, LA 70803, USA
    Proc Natl Acad Sci U S A 98:12084-8. 2001
    ..The maintenance of this sterility allows the species to persist in the face of gene flow longer than without such inversions, and natural selection will have a greater opportunity to decrease the frequency of interspecies matings...
  2. ncbi The genome sequence of the malaria mosquito Anopheles gambiae
    Robert A Holt
    Celera Genomics, 45 West Gude Drive, Rockville, MD 20850, USA
    Science 298:129-49. 2002
    ..An expressed sequence tag analysis of genes regulated by blood feeding provided insights into the physiological adaptations of a hematophagous insect...
  3. pmc Ecological niche partitioning between Anopheles gambiae molecular forms in Cameroon: the ecological side of speciation
    Frederic Simard
    Laboratoire de Lutte contre les Insectes Nuisibles, Institut de Recherche pour le Developpement, UR016, 911 Av Agropolis, Cedex 5, Montpellier, France
    BMC Ecol 9:17. 2009
    ....
  4. ncbi Extensive rearrangements in the chloroplast genome of Trachelium caeruleum are associated with repeats and tRNA genes
    Rosemarie C Haberle
    Section of Integrative Biology and Institute of Cellular and Molecular Biology, University of Texas, Austin, TX 78712, USA
    J Mol Evol 66:350-61. 2008
    ..Genes for tRNAs occur at many but not all inversion endpoints, so some combination of repeats and tRNA genes may have mediated these rearrangements...
  5. pmc Chromosome inversions, local adaptation and speciation
    Mark Kirkpatrick
    Section of Integrative Biology, University of Texas, Austin 78712, USA
    Genetics 173:419-34. 2006
    ..We discuss data that support the hypothesis, review other mechanisms for inversion evolution, and suggest possible tests...
  6. pmc Ecological genomics of Anopheles gambiae along a latitudinal cline: a population-resequencing approach
    Changde Cheng
    Eck Institute for Global Health, Department of Biological Sciences, University of Notre Dame, Notre Dame, Indiana 46556, USA
    Genetics 190:1417-32. 2012
    ..These results, coupled with similar conclusions from studies of clinal variation in Drosophila, point to a number of important biological functions associated with local environmental adaptation...
  7. pmc Paired-end mapping reveals extensive structural variation in the human genome
    Jan O Korbel
    Molecular Biophysics and Biochemistry Department, Yale University, New Haven, CT 06520, USA
    Science 318:420-6. 2007
    ..The breakpoint junction sequences of more than 200 SVs were determined with a novel pooling strategy and computational analysis. Our analysis provided insights into the mechanisms of SV formation in humans...
  8. ncbi Chromosomal speciation and molecular divergence--accelerated evolution in rearranged chromosomes
    Arcadi Navarro
    Departament de Ciencies Experimentals i de la Salut, Universitat Pompeu Fabra, Doctor Aiguader 80, 08003 Barcelona, Catalonia, Spain
    Science 300:321-4. 2003
    ..Also, nucleotide variability is slightly lower in rearranged chromosomes. These patterns of divergence and polymorphism may be, at least in part, the molecular footprint of speciation events in the human and chimpanzee lineages...
  9. pmc Nucleotide, cytogenetic and expression impact of the human chromosome 8p23.1 inversion polymorphism
    Nina Bosch
    Genetic Causes of Disease Group, Genes and Disease Programme Center for Genomic Regulation CRG UPF, Barcelona, Catalonia, Spain
    PLoS ONE 4:e8269. 2009
    ..The identification of single nucleotide polymorphisms (SNPs) tightly linked to the genomic orientation of a given region should be useful to indirectly evaluate the genotypes of large genomic orientations in the individuals...
  10. ncbi Extensive DNA inversions in the B. fragilis genome control variable gene expression
    Ana M Cerdeño-Tárraga
    Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SA, UK
    Science 307:1463-5. 2005
    ..The composition of the 10 different polysaccharide biosynthesis gene clusters identified (7 with associated invertible promoters) suggests a mechanism of synthesis similar to the O-antigen capsules of Escherichia coli...
  11. pmc The population genomics of trans-specific inversion polymorphisms in Anopheles gambiae
    Bradley J White
    Eck Institute for Global Health, Department of Biological Sciences, University of Notre Dame, Notre Dame, Indiana 46556, USA
    Genetics 183:275-88. 2009
    ..gambiae and its sibling species An. arabiensis...
  12. pmc Recurrent inversion events at 17q21.31 microdeletion locus are linked to the MAPT H2 haplotype
    P N Rao
    Department of Pathology and Laboratory Medicine, University of California Los Angeles, Los Angeles, Calif 90095, USA
    Cytogenet Genome Res 129:275-9. 2010
    ..31 microdeletion syndrome. Our results highlight an allele-specific sensitivity to chromosome rearrangements and suggest that it is the heterozygosity of inversion status that predisposes to the 17q21.31 microdeletion syndrome...
  13. pmc The transposon Galileo generates natural chromosomal inversions in Drosophila by ectopic recombination
    Alejandra Delprat
    Departament de Genetica i de Microbiologia, Universitat Autonoma de Barcelona, Bellaterra Barcelona, Spain
    PLoS ONE 4:e7883. 2009
    ..Previous work revealed that the transposon Galileo was involved in the generation of two polymorphic inversions of Drosophila buzzatii...
  14. ncbi Generation of a widespread Drosophila inversion by a transposable element
    M Caceres
    Departament de Genetica i de Microbiologia, Universitat Autonoma de Barcelona, 08193 Bellaterra Barcelona, Spain
    Science 285:415-8. 1999
    ..This is apparently the mechanism by which transposable elements generate natural inversions in Drosophila...
  15. ncbi Complete chloroplast genome sequences from Korean ginseng (Panax schinseng Nees) and comparative analysis of sequence evolution among 17 vascular plants
    Ki Joong Kim
    School of Life Sciences and Biotechnology, Korea University, Seoul 136 701, Korea
    DNA Res 11:247-61. 2004
    ..Large-sized indels were often associated with direct repeats at the end of the sequences facilitating intra-molecular recombination...
  16. pmc Fragile regions and not functional constraints predominate in shaping gene organization in the genus Drosophila
    Marcin von Grotthuss
    Department of Ecology and Evolutionary Biology, University of California Irvine, Irvine, California 92697, USA
    Genome Res 20:1084-96. 2010
    ..Fragile regions rather than functional constraints have been the main determinant of the evolution of the Drosophila chromosomes...
  17. pmc Localization of candidate regions maintaining a common polymorphic inversion (2La) in Anopheles gambiae
    Bradley J White
    Center for Global Health and Infectious Diseases, Department of Biological Sciences, University of Notre Dame, Notre Dame, Indiana, USA
    PLoS Genet 3:e217. 2007
    ....
  18. pmc Characterization of six human disease-associated inversion polymorphisms
    Francesca Antonacci
    Department of Genome Sciences, Howard Hughes Medical Institute, University of Washington, Seattle, WA 98195, USA
    Hum Mol Genet 18:2555-66. 2009
    ..In these cases, discovery and genotyping methods based on SNPs may be confounded and molecular cytogenetics remains the only method to genotype these inversions...
  19. pmc Ecological and genetic relationships of the Forest-M form among chromosomal and molecular forms of the malaria vector Anopheles gambiae sensu stricto
    Yoosook Lee
    School of Veterinary Medicine, Department of Pathology, Microbiology and Immunology, University of California Davis, Davis, CA, USA
    Malar J 8:75. 2009
    ..Recent studies suggest that the M form found in Cameroon is genetically distinct from the M form found in Mali and elsewhere in West Africa, suggesting further subdivision within that form...
  20. pmc On the power and the systematic biases of the detection of chromosomal inversions by paired-end genome sequencing
    José Ignacio Lucas Lledó
    Institut de Biotecnologia i de Biomedicina, Universitat Autonoma de Barcelona, Bellaterra, Barcelona, Spain
    PLoS ONE 8:e61292. 2013
    ..These results stress the importance of the sequencing strategy for the detection of structural variants, especially inversions, and offer guidelines for the design of future genome sequencing projects...
  21. pmc Breakpoint cloning and haplotype analysis indicate a single origin of the common Inv(10)(p11.2q21.2) mutation among northern Europeans
    Mette Gilling
    Wilhelm Johannsen Center for Functional Genome Research, University of Copenhagen, Copenhagen
    Am J Hum Genet 78:878-83. 2006
    ..Thus, although considered a common variant, inv(10)(p11.2q21.2) has a single ancestral founder among northern Europeans...
  22. ncbi Latitudinal clines in Drosophila melanogaster: body size, allozyme frequencies, inversion frequencies, and the insulin-signalling pathway
    Gerdien de Jong
    Evolutionary Population Biology, Utrecht University, Padualaan 8, NL 3584 CH Utrecht, Netherlands
    J Genet 82:207-23. 2003
    ....
  23. pmc Effect of inversion polymorphism on the neutral nucleotide variability of linked chromosomal regions in Drosophila
    A Navarro
    Departament de Genetica i de Microbiologia, Universitat Autonoma de Barcelona, Spain
    Genetics 155:685-98. 2000
    ..The implications of these findings for overall variability levels during the evolution of Drosophila species are discussed...
  24. pmc Mapping regions within cosmopolitan inversion In(3R)Payne associated with natural variation in body size in Drosophila melanogaster
    W Jason Kennington
    Centre for Evolutionary Biology, School of Animal Biology, The University of Western Australia, Crawley, Western Australia 6009, Australia
    Genetics 177:549-56. 2007
    ....
  25. ncbi Adaptive chromosomal divergence driven by mixed geographic mode of evolution
    Jeffrey L Feder
    Department of Biological Sciences, University of Notre Dame, Notre Dame, IN 46556, USA
    Evolution 65:2157-70. 2011
    ..As inversion differences often separate closely related taxa, mixed modes of divergence could be common...
  26. ncbi Chromosomal inversions and species differences: when are genes affecting adaptive divergence and reproductive isolation expected to reside within inversions?
    Jeffrey L Feder
    Biological Sciences, University of Notre Dame, Notre Dame, Indiana 46556, USA
    Evolution 63:3061-75. 2009
    ..We also find that strong selection facilitates maintenance of divergence in a manner analogous to inversions...
  27. ncbi The evolution of chloroplast genome structure in ferns
    Paul G Wolf
    Department of Biology, and Ecology Center, Utah State University, Logan, UT 84322, USA
    Genome 53:731-8. 2010
    ..This is because the intron loss maps to an earlier point on the phylogeny than the nearby inversion. We speculate on why inversions may occur in pairs and what this may mean for the dynamics of plastome evolution...
  28. ncbi A common inversion under selection in Europeans
    Hreinn Stefansson
    deCODE Genetics, Sturlugata 8, 101 Reykjavik, Iceland
    Nat Genet 37:129-37. 2005
    ..Here we show that the H2 lineage is undergoing positive selection in the Icelandic population, such that carrier females have more children and have higher recombination rates than noncarriers...
  29. pmc Discovery of human inversion polymorphisms by comparative analysis of human and chimpanzee DNA sequence assemblies
    Lars Feuk
    The Centre for Applied Genomics, Department of Genetics and Genomic Biology, The Hospital for Sick Children, Toronto, Ontario, Canada
    PLoS Genet 1:e56. 2005
    ..The finding of at least three novel inversion polymorphisms in humans indicates this type of structural variation may be a more common feature of our genome than previously realized...
  30. pmc Genomic impacts of chromosomal inversions in parapatric Drosophila species
    Suzanne E McGaugh
    Biology Department, Duke University, Box 90388, Durham, NC 27708, USA
    Philos Trans R Soc Lond B Biol Sci 367:422-9. 2012
    ..We also hypothesize that the inversions in D. persimilis may provide an empirical example of the 'mixed geographical mode' theory of inversion origin and fixation, whereby allopatry and secondary contact both play a role...
  31. pmc The distribution and most recent common ancestor of the 17q21 inversion in humans
    Michael P Donnelly
    Department of Genetics, School of Medicine, Yale University, New Haven, CT 06520, USA
    Am J Hum Genet 86:161-71. 2010
    ..This estimate range is much more recent than the 3 million year age estimated by Stefansson et al. in 2005...
  32. pmc A widespread chromosomal inversion polymorphism contributes to a major life-history transition, local adaptation, and reproductive isolation
    David B Lowry
    University Program in Genetics and Genomics, Duke University Medical Center, Durham, North Carolina, United States of America
    PLoS Biol 8:. 2010
    ..Such a mechanism may be partially responsible for the observation that closely related species often differ by multiple chromosomal rearrangements...
  33. ncbi Inversion-induced disruption of the Hoxd cluster leads to the partition of regulatory landscapes
    Francois Spitz
    National Research Centre Frontiers in Genetics, Department of Zoology and Animal Biology University of Geneva, Sciences III, Quai Ernest Ansermet 30, 1211 Geneva 4, Switzerland
    Nat Genet 37:889-93. 2005
    ..This approach can be used to study the relationship between genome architecture and gene expression, such as the effects of genome rearrangements in human diseases or during evolution...
  34. pmc Divergence with gene flow in Anopheles funestus from the Sudan Savanna of Burkina Faso, West Africa
    Andrew P Michel
    Center for Tropical Disease Research and Training, Department of Biological Sciences, University of Notre Dame, Indiana 46556, USA
    Genetics 173:1389-95. 2006
    ..These data are not compatible with complete reproductive isolation but are consistent with differential introgression and sympatric divergence between the chromosomal forms, facilitated by chromosome 3R inversions...
  35. pmc Molecular characterization of two natural hotspots in the Drosophila buzzatii genome induced by transposon insertions
    M Caceres
    Departament de Genetica i de Microbiologia, Universitat Autonoma de Barcelona, 08193 Bellaterra, Barcelona, Spain
    Genome Res 11:1353-64. 2001
    ..Together, our results strengthen the importance of TEs, and especially DNA transposons, as inducers of genome plasticity in evolution...
  36. pmc Genome sequence of Shigella flexneri 2a: insights into pathogenicity through comparison with genomes of Escherichia coli K12 and O157
    Qi Jin
    State Key Laboratory for Molecular Virology and Genetic Engineering, Beijing 100052, China
    Nucleic Acids Res 30:4432-41. 2002
    ..coli strains. All of these could be subjected to investigations towards novel preventative and treatment strategies against shigellosis...
  37. ncbi Global genetic change tracks global climate warming in Drosophila subobscura
    Joan Balanyà
    Department of Genetics, Faculty of Biology, University of Barcelona, Diagonal 645, Barcelona 08071, Spain
    Science 313:1773-5. 2006
    Comparisons of recent with historical samples of chromosome inversion frequencies provide opportunities to determine whether genetic change is tracking climate change in natural populations...
  38. pmc Patterns of diversity and linkage disequilibrium within the cosmopolitan inversion In(3R)Payne in Drosophila melanogaster are indicative of coadaptation
    W Jason Kennington
    School of Animal Biology, University of Western Australia, Crawley, Australia
    Genetics 172:1655-63. 2006
    ..Our results provide some support for the hypothesis that inversions persist in natural populations because they hold together favorable combinations of alleles that act together to facilitate adaptive shifts...
  39. ncbi The foldback-like transposon Galileo is involved in the generation of two different natural chromosomal inversions of Drosophila buzzatii
    Ferran Casals
    Departament de Genetica i de Microbiologia, Universitat Autonoma de Barcelona, Bellaterra Barcelona, Spain
    Mol Biol Evol 20:674-85. 2003
    ..The possibility that this instability is caused by structural properties of Foldback elements is discussed...
  40. ncbi Inverted duplications deletions: underdiagnosed rearrangements??
    O Zuffardi
    Biologia Generale e Genetica Medica, Universita di Pavia, Pavia, Italy
    Clin Genet 75:505-13. 2009
    ..Obviously, the concomitant presence of deletion and duplication has important consequences in genotype/phenotype correlations...
  41. pmc The tandem inversion duplication in Salmonella enterica: selection drives unstable precursors to final mutation types
    Elisabeth Kugelberg
    Department of Microbiology, College of Biological Sciences, University of California, Davis, CA 95616, USA
    Genetics 185:65-80. 2010
    ..Growth improves with each step in formation of an SJ or aTID amplification, allowing selection to favor completion of the mutation process...
  42. ncbi Recurrent inversion breaking intron 1 of the factor VIII gene is a frequent cause of severe hemophilia A
    Richard D Bagnall
    Division of Medical and Molecular Genetics, Guy s, King s, and St Thomas School of Medicine, London, United Kingdom
    Blood 99:168-74. 2002
    ..This indicates a prevalence of 4.8% and frequent recurrence of the inversion. This should result in absence of F8, and one inversion patient is known to have inhibitors. (Blood. 2002;99:168-174)..
  43. ncbi Heritable skewed X-chromosome inactivation leads to haemophilia A expression in heterozygous females
    Nisa K Renault
    Department of Pathology, Dalhousie University, Halifax, Nova Scotia, Canada
    Eur J Hum Genet 15:628-37. 2007
    ..Further, the findings suggest that these XCI ratios are genetically influenced, consistent with a novel heritable human X controlling element (XCE) functioning similarly to the mouse Xce...
  44. ncbi Desiccation resistance among subpopulations of Anopheles gambiae s.s. from Selinkenyi, Mali
    Yoosook Lee
    School of Veterinary Medicine, Department of Pathology, Microbiology and Immunology, University of California Davis, Davis, CA 95616, USA
    J Med Entomol 46:316-20. 2009
    ..Our study supports a genetic link to the drought tolerance phenotype, a phenotype with important consequences to malaria transmission in many places in Africa...
  45. pmc Sox6 is a candidate gene for p100H myopathy, heart block, and sudden neonatal death
    N Hagiwara
    Department of Pediatrics, The University of Arizona College of Medicine, Tucson, AZ 85724, USA
    Proc Natl Acad Sci U S A 97:4180-5. 2000
    ..The p(100H) mutant is thus a useful animal model in the elucidation of myopathies at the molecular level...
  46. ncbi Chromosome evolution in bats as revealed by FISH: the ongoing search for the ancestral chiropteran karyotype
    M Volleth
    Department of Human Genetics, Otto von Guericke University, Magdeburg, Germany
    Cytogenet Genome Res 137:165-73. 2012
    ..Given our present knowledge of chiropteran karyotypes, only a few elements of the ancestral chiropteran karyotype can be reconstructed with confidence...
  47. pmc Chromosome-wide linkage disequilibrium caused by an inversion polymorphism in the white-throated sparrow (Zonotrichia albicollis)
    L Y Huynh
    Graduate Program in Population Biology, Ecology and Evolution, Emory University, Atlanta, GA, USA
    Heredity (Edinb) 106:537-46. 2011
    ....
  48. ncbi Mechanisms of formation of structural variation in a fully sequenced human genome
    Andy Wing Chun Pang
    Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada
    Hum Mutat 34:345-54. 2013
    ..3 and 6q27) of potential reference assembly orientation errors were found. This study provides a thorough account of formation mechanisms for structural variants, and reveals a glimpse of the dynamic structure of inversions...
  49. pmc Chromosome 17: association of a large inversion polymorphism with corticosteroid response in asthma
    Kelan G Tantisira
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Pharmacogenet Genomics 18:733-7. 2008
    ..Additional pharmacogenetic investigations into regions of chromosomal diversity, including copy number variation and inversions, are warranted...
  50. ncbi 47,X,idic(Y),inv dup(Y): a non-mosaic case of a phenotypically normal boy with two different Y isochromosomes and neocentromere formation
    J J Pasantes
    Department of Biochemistry, Genetics and Immunology, University of Vigo, Vigo, Spain
    Cytogenet Genome Res 136:157-62. 2012
    ..Because of its stable mitotic distribution, a de novo formation of a neocentromere has to be assumed...
  51. ncbi Selection for chromosome architecture in bacteria
    Heather Hendrickson
    Department of Biological Sciences, University of Pittsburgh, Pittsburgh, PA 15260, USA
    J Mol Evol 62:615-29. 2006
    ....
  52. pmc Genome rearrangements in maize induced by alternative transposition of reversed ac/ds termini
    Chuanhe Yu
    Department of Genetics, Iowa State University, Ames, Iowa 50011, USA
    Genetics 188:59-67. 2011
    ..These results document the types and frequencies of genome rearrangements induced by alternative transposition of reversed Ac/Ds termini in maize...
  53. pmc Gene alterations at Drosophila inversion breakpoints provide prima facie evidence for natural selection as an explanation for rapid chromosomal evolution
    Yolanda Guillén
    Departament de Genetica i de Microbiologia, Universitat Autonoma de Barcelona, 08193 Bellaterra Barcelona, Spain
    BMC Genomics 13:53. 2012
    ..D. mojavensis, an ecological specialist adapted to a cactophilic niche under extreme desert conditions, is a chromosomally derived species with ten fixed inversions, five of them not present in any other species...
  54. ncbi Evolutionary history of the third chromosome gene arrangements of Drosophila pseudoobscura inferred from inversion breakpoints
    Andre G Wallace
    Department of Biology, The Pennsylvania State University, Mueller Laboratory, PA, USA
    Mol Biol Evol 28:2219-29. 2011
    ..One of the youngest arrangements, Arrowhead, has one of the highest population frequencies suggesting that selection has been responsible for its rapid increase...
  55. ncbi The association between inversion In(3R)Payne and clinally varying traits in Drosophila melanogaster
    L Rako
    Department of Genetics Centre for Environmental Stress and Adaptation Research CESAR, The University of Melbourne, 3010, Parkville, Vic, Australia
    Genetica 128:373-84. 2006
    ..Because the size difference between karyotypes was similar in different populations, there was no evidence for coadaptation within populations...
  56. ncbi Genomic architecture of human 17q21 linked to frontotemporal dementia uncovers a highly homologous family of low-copy repeats in the tau region
    Marc Cruts
    Department of Molecular Genetics, Flanders Interuniversity Institute for Biotechnology, University of Antwerp, Antwerpen, Belgium
    Hum Mol Genet 14:1753-62. 2005
    ..The presence of multiple homologous LCRs in the region predicts that other potentially more complex genomic rearrangements might be underlying FTDU-17...
  57. ncbi Complete nucleotide sequence of the chloroplast genome from a leptosporangiate fern, Adiantum capillus-veneris L
    Paul G Wolf
    Department of Biology, Utah State University, 5305 Old Main Hill, Logan, UT 84322, USA
    DNA Res 10:59-65. 2003
    ..The missing trnK gene appears to have been disrupted by a large inversion, relative to other published chloroplast genomes. We detected several structural rearrangements that may provide useful information for phylogenetic studies...
  58. pmc Chromosomal inversion polymorphism leads to extensive genetic structure: a multilocus survey in Drosophila subobscura
    Agustí Munté
    Departament de Genetica, Facultat de Biologia, Universitat de Barcelona, Spain
    Genetics 169:1573-81. 2005
    ..subobscura, but also in the genome of other species with a rich chromosomal polymorphism...
  59. ncbi Visualization of fine-scale genomic structure by oligonucleotide-based high-resolution FISH
    N A Yamada
    Agilent Laboratories, Agilent Technologies, Santa Clara, Calif, USA
    Cytogenet Genome Res 132:248-54. 2011
    ....
  60. ncbi Identification and frequency estimation of inversion polymorphisms from haplotype data
    Suzanne S Sindi
    Division of Applied Mathematics, Brown University, Providence, Rhode Island 02912, USA
    J Comput Biol 17:517-31. 2010
    ..Many of these correspond to known inversions or have other evidence supporting them, and the predicted inversion frequencies largely agree with the limited information presently available...
  61. pmc Mutational mechanisms of Williams-Beuren syndrome deletions
    Mònica Bayés
    Unitat de Genètica, Departament Ciències Experimentals i de la Salut, Universitat Pompeu Fabra, Doctor Aiguader 80, 08003 Barcelona, Spain
    Am J Hum Genet 73:131-51. 2003
    ..Chromosomal instability at 7q11.23 is directly related to the genomic structure of the region...
  62. pmc Sequence-based detection and breakpoint assembly of polymorphic inversions
    Russell B Corbett-Detig
    Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    Genetics 192:131-7. 2012
    ..melanogaster inversions as well as a framework for detection and assay design of inversions and other chromosome aberrations in diverse taxa...
  63. ncbi Optical maps distinguish individual strains of Escherichia coli O157 : H7
    Michael L Kotewicz
    Division of Molecular Biology, Office of Applied Research and Safety Assessment, Center for Food Safety and Applied Nutrition, US Food and Drug Administration, Laurel, MD 20708, USA
    Microbiology 153:1720-33. 2007
    ..The optical maps defined unique genome landmarks in each of the strains and demonstrated the ability of optical mapping to distinguish and differentiate, at the individual level, strains of this important pathogen...
  64. ncbi Recombination and selection in the maintenance of the adaptive value of inversions
    C Pegueroles
    Departament de Genetica, Facultat de Biologia, Universitat de Barcelona, Barcelona, Spain
    J Evol Biol 23:2709-17. 2010
    ....
  65. pmc High-resolution cytogenetic map for the African malaria vector Anopheles gambiae
    P George
    Department of Entomology, Virginia Tech, Blacksburg, VA, USA
    Insect Mol Biol 19:675-82. 2010
    ..The map's increased resolution can be used to further enhance physical mapping, improve genome assembly, and stimulate epigenomic studies of malaria vectors...
  66. ncbi Molecular differentiation between chromosomally defined incipient species of Anopheles funestus
    A P Michel
    Center for Tropical Disease Research and Training, Department of Biological Sciences, University of Notre Dame, IN 46556, USA
    Insect Mol Biol 14:375-87. 2005
    ..The molecular evidence from this study is consistent with the hypothesis of incipient speciation between Kiribina and Folonzo...
  67. pmc Mapping and sequencing of structural variation from eight human genomes
    Jeffrey M Kidd
    Department of Genome Sciences and Howard Hughes Medical Institute, University of Washington, Seattle, Washington 98195, USA
    Nature 453:56-64. 2008
    ..These data provide the first high-resolution sequence map of human structural variation--a standard for genotyping platforms and a prelude to future individual genome sequencing projects...
  68. pmc Chromosomal inversions, natural selection and adaptation in the malaria vector Anopheles funestus
    Diego Ayala
    Institut de Recherche pour le Developpement, UR016 CCPV, Montpellier, France
    Mol Biol Evol 28:745-58. 2011
    ....
  69. pmc Optical mapping reveals a large genetic inversion between two methicillin-resistant Staphylococcus aureus strains
    Sanjay K Shukla
    Marshfield Clinic Research Foundation, 1000 North Oak Avenue, Marshfield, Wisconsin 54449, USA
    J Bacteriol 191:5717-23. 2009
    ..At both the left and right junction sites in NRS387, an IS1181 element and a 73-bp sequence were identified as inverted repeats, which could explain the possible mechanism of the inversion event...
  70. ncbi Efficient sorting of genomic permutations by translocation, inversion and block interchange
    Sophia Yancopoulos
    The Feinstein Institute for Medical Research North Shore LIJ Health System, Manhasset, NY 11030, USA
    Bioinformatics 21:3340-6. 2005
    ..We seek a universal operation underlying a more inclusive set of evolutionary operations and yielding a tractable genomic distance with simple mathematical form...
  71. pmc Evolutionary genomics of inversions in Drosophila pseudoobscura: evidence for epistasis
    Stephen W Schaeffer
    Department of Biology and Institute of Molecular Evolutionary Genetics, Pennsylvania State University, University Park, PA 16802 5301, USA
    Proc Natl Acad Sci U S A 100:8319-24. 2003
    ..pseudoobscura have emerged as suppressors of recombination to maintain positive epistatic relationships among loci within gene arrangements that developed as the species adapted to a heterogeneous environment...
  72. ncbi Chromosomal inversion polymorphism in Afrotropical populations of Drosophila melanogaster
    Sylvie Aulard
    Laboratoire Populations, Genetique et Evolution, Centre National de la Recherche Scientifique, 91198 Gif sur Yvette, France
    Genet Res 79:49-63. 2002
    ..The present geographic pattern suggests a long, patchy evolution with restricted gene flow, followed by the modern period with numerous recent migrations linked to human transportation...
  73. pmc Silencing of a gene adjacent to the breakpoint of a widespread Drosophila inversion by a transposon-induced antisense RNA
    Marta Puig
    Departament de Genetica i de Microbiologia, Universitat Autonoma de Barcelona, 08193 Bellaterra, Barcelona, Spain
    Proc Natl Acad Sci U S A 101:9013-8. 2004
    ..In addition, because chromosomal rearrangements are usually induced by TEs, position effects might be more common than previously recognized and contribute significantly to the evolutionary success of inversions...
  74. pmc Evaluation of the genomic extent of effects of fixed inversion differences on intraspecific variation and interspecific gene flow in Drosophila pseudoobscura and D. persimilis
    Carlos A Machado
    Department of Ecology and Evolutionary Biology, University of Arizona, Tucson, Arizona 85721, USA
    Genetics 175:1289-306. 2007
    ..persimilis and near one breakpoint, consistent with a scenario in which this inversion arose and was fixed in this species by natural selection...
  75. pmc Mechanisms of genetic exchange within the chromosomal inversions of Drosophila pseudoobscura
    Stephen W Schaeffer
    Department of Biology and Institute of Molecular Evolutionary Genetics, Pennsylvania State University, 208 Erwin W Mueller Laboratories, University Park, PA 16802 5301, USA
    Genetics 171:1729-39. 2005
    ..At least one case where selection rather than proximity to an inversion breakpoint is responsible for reduction in polymorphism was identified...
  76. pmc Arm-specific dynamics of chromosome evolution in malaria mosquitoes
    Maria V Sharakhova
    Department of Entomology, Virginia Tech, Blacksburg, VA 24061, USA
    BMC Evol Biol 11:91. 2011
    ..It is also unclear if the evolutionary breakage of inversion-poor chromosomal arms is under constraints...
  77. pmc Recombination and gene flux caused by gene conversion and crossing over in inversion heterokaryotypes
    A Navarro
    Departament de Genetica i de Microbiologia, Universitat Autonoma de Barcelona, Bellaterra, Spain
    Genetics 146:695-709. 1997
    ..Because inversions are ubiquitous in the evolutionary history of many Drosophila species, the effects of inversions on recombination are expected to influence DNA variation patterns...
  78. ncbi A tightly regulated inducible expression system utilizing the fim inversion recombination switch
    Timothy S Ham
    Department of Bioengineering, University of California, Berkeley, 94720, USA
    Biotechnol Bioeng 94:1-4. 2006
    ..These characteristics make our system suitable for large-scale expression or for production of toxic proteins...
  79. pmc Cytogenetic map for Anopheles nili: application for population genetics and comparative physical mapping
    Maria V Sharakhova
    Department of Entomology, Virginia Tech, Blacksburg, VA 24061, United States
    Infect Genet Evol 11:746-54. 2011
    ..Availability of the new polytene chromosome map, polymorphic inversions, and physically mapped DNA markers for An. nili will further stimulate population genetic, taxonomic, and genomic studies of this neglected malaria vector...
  80. ncbi A chromosome inversion near the KIT gene and the Tobiano spotting pattern in horses
    S A Brooks
    Department of Veterinary Science, University of Kentucky, Lexington, KY, USA
    Cytogenet Genome Res 119:225-30. 2007
    ..Here, we report TO associated with a large paracentric chromosome inversion on horse chromosome 3...
  81. ncbi Swift laboratory thermal evolution of wing shape (but not size) in Drosophila subobscura and its relationship with chromosomal inversion polymorphism
    M Santos
    Grup de Biologia Evolutiva GBE, Departament de Genetica i de Microbiologia, Universitat Autonoma de Barcelona, Barcelona, Spain
    J Evol Biol 17:841-55. 2004
    ..These findings cast strong doubts on the supposed 'unpredictability' of the geographical cline for wing traits in D. subobscura North American colonizing populations...
  82. pmc Contrasting histories of three gene regions associated with In(3L)Payne of Drosophila melanogaster
    E Hasson
    Department of Ecology and Evolution, State University of New York, Stony Brook 11794, USA
    Genetics 144:1565-75. 1996
    ..36 million yr old. Although it is widely accepted that inversions are examples of balanced polymorphisms, none of the current neutrality tests including our Monte Carlo simulations showed significant departure from neutral expectations...
  83. pmc Molecular inversion probe analysis of gene copy alterations reveals distinct categories of colorectal carcinoma
    Hanlee Ji
    Division of Oncology, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305 5151, USA
    Cancer Res 66:7910-9. 2006
    ..This finding has potential clinical ramifications given the application of 18q loss of heterozygosity events as a potential indicator for adjuvant treatment in stage II colorectal carcinoma...
  84. ncbi GRIL: genome rearrangement and inversion locator
    Aaron E Darling
    Department of Computer Science, University of Wisconsin Madison, 1656 Linden Dr, Madison, WI 53706, USA
    Bioinformatics 20:122-4. 2004
    ..By locating collinear regions of sequence, GRIL provides a basis for multiple genome alignment using current alignment systems. GRIL also provides a basis for using current inversion distance tools to infer phylogeny...
  85. pmc Chromosomal rearrangement inferred from comparisons of 12 Drosophila genomes
    Arjun Bhutkar
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    Genetics 179:1657-80. 2008
    ..On the other hand, an analysis of the disruption of syntenic blocks between species allowed the identification of fixed inversion breakpoints and estimates of breakpoint reuse and lineage-specific breakpoint event segregation...
  86. ncbi Cytogenetically cryptic AML1-ETO and CBF beta-MYH11 gene rearrangements: incidence in 412 cases of acute myeloid leukaemia
    D Rowe
    School of Biochemistry and Genetics, University of Newcastle upon Tyne, UK
    Br J Haematol 111:1051-6. 2000
    ..Our data concur with the established FAB type distribution of the rearrangements and indicate that cryptic t(8;21) and inv(16) may be much less frequent than reported elsewhere...
  87. pmc A familial inverted duplication/deletion of 2p25.1-25.3 provides new clues on the genesis of inverted duplications
    Maria Clara Bonaglia
    Scientific Institute Eugenio Medea, Bosisio Parini, Lecco, Italy
    Eur J Hum Genet 17:179-86. 2009
    ..The phenotypic effects of the trisomy and of the terminal 2p deletion are discussed...
  88. ncbi The evolutionary history of human chromosome 7
    Stefan Muller
    Institute for Anthropology and Human Genetics, Department of Biology II, Ludwig Maximilians University, Richard Wagner Strasse 10, D 80333 Munich, Germany
    Genomics 84:458-67. 2004
    ..We propose a scenario by which segmental duplications may have been the cause rather than the result of these chromosome rearrangements...
  89. pmc Transposon Ac/Ds-induced chromosomal rearrangements at the rice OsRLG5 locus
    Yuan hu Xuan
    Division of Applied Life Science BK21 program, Plant Molecular Biology and Biotechnology Research Center PMBBRC, Gyeongsang National University, Jinju 660 701, Korea
    Nucleic Acids Res 39:e149. 2011
    ..Together, these results demonstrate a greatly enlarged potential of the Ac/Ds system for plant chromosome engineering...
  90. ncbi Bayesian estimation of the number of inversions in the history of two chromosomes
    Thomas L York
    Department of Biological Statistics and Computational Biology, Cornell University, Ithaca, NY 14853, USA
    J Comput Biol 9:805-18. 2002
    ..melanogaster comparison, the lower boundary of a 95% highest posterior density credible interval for the number of inversions is considerably larger than the most parsimonious number of inversions...
  91. pmc Polytene chromosomes as indicators of phylogeny in several species groups of Drosophila
    P M O'Grady
    Division of Invertebrate Zoology, American Museum of Natural History, New York, USA
    BMC Evol Biol 1:6. 2001
    ..We place the classical Drosophila evolutionary biology tools of polytene chromosome inversion analysis in a phylogenetic context and assess their utility in comparison to nucleotide sequences.
  92. pmc Divergence between the Drosophila pseudoobscura and D. persimilis genome sequences in relation to chromosomal inversions
    Mohamed A F Noor
    Biology Department, Duke University, Durham, North Carolina 27708, USA
    Genetics 177:1417-28. 2007
    ..This reliance highlights the need for complementary genomic and population genetic approaches for tackling fundamental evolutionary questions such as speciation...
  93. ncbi Temephos-resistant larvae of Simulium sanctipauli associated with a distinctive new chromosome inversion in untreated rivers of south-western Ghana
    M Y Osei-Atweneboana
    Parasitology Unit, Noguchi Memorial Institute for Medical Research, University of Ghana, Legon
    Med Vet Entomol 15:113-6. 2001
    ..This resistance could have been locally selected by exposure of S. sanctipauli larval populations to agrochemicals run-off from cocoa, coffee and oil plantations flanking the rivers...
  94. ncbi Two chloroplast DNA inversions originated simultaneously during the early evolution of the sunflower family (Asteraceae)
    Ki Joong Kim
    School of Life Sciences and Biotechnology, Korea University, Seoul, Korea
    Mol Biol Evol 22:1783-92. 2005
    ..The divergence time estimates also suggest that the Asteraceae originated in the mid Eocene (42-47 MYA)...
  95. ncbi Reconstructing ancestral autosomal arrangements in the Anopheles gambiae complex
    Ai Xia
    Department of Entomology, Virginia Tech, Blacksburg, VA 24061, USA
    J Comput Biol 15:965-80. 2008
    ..Molecular characterization of the breakpoints in both ingroup and outgroup species will provide a solid basis for reconstructing the inversion history in the A. gambiae complex...
  96. ncbi Cytogenetics of the Anopheles gambiae complex in Sudan, with special reference to An. arabiensis: relationships with East and West African populations
    V Petrarca
    Department of Genetics and Molecular Biology, Institute of Parasitology, University La Sapienza, Rome, Italy
    Med Vet Entomol 14:149-64. 2000
    ..Sudan populations have more evident similarities with those from westwards than those from eastwards of the Great Rift Valley. The possible influence of the Rift on evolution of An. arabiensis is discussed...
  97. ncbi X-linked congenital adrenal hypoplasia with hypogonadotropic hypogonadism caused by an inversion disrupting a conserved noncoding element upstream of the NR0B1 (DAX1) gene
    Beate Skinningsrud
    Department of Medical Genetics, Oslo University Hospital, Ulleval, N 0407 Oslo, Norway
    J Clin Endocrinol Metab 94:4086-93. 2009
    ....
  98. pmc Distribution of the transposable elements bilbo and gypsy in original and colonizing populations of Drosophila subobscura
    María Pilar García Guerreiro
    Grup de Biologia Evolutiva, Departament de Genetica i Microbiologia, Facultat de Biociencies, Universitat Autonoma de Barcelona, 08193 Bellaterra Barcelona, Spain
    BMC Evol Biol 8:234. 2008
    ..In this work we study the chromosomal distribution of two TEs, gypsy and bilbo, in original and colonizing populations of Drosophila subobscura to reveal the putative effect of colonization on their insertion profile...
  99. pmc Molecular evolution of inversions in Drosophila pseudoobscura: the amylase gene region
    C F Aquadro
    Laboratory of Genetics, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709
    Proc Natl Acad Sci U S A 88:305-9. 1991
    ..Clustering the restriction map haplotypes yielded a dendrogram concordant with the phylogeny generated independently from cytogenetic considerations. The inversion polymorphism is estimated to be about 2 million years old...
  100. ncbi Identification of a site-specific tyrosine recombinase that mediates promoter inversions of phase-variable mpl lipoprotein genes in Mycoplasma penetrans
    Atsuko Horino
    Department of Bacterial Pathogenesis and Infection Control, National Institute of Infectious Diseases, Musashimurayama, Tokyo 208 0011, Japan
    Microbiology 155:1241-9. 2009
    ..penetrans HF-2 cells. All these promoter inversions occurred at the 12 bp inverted repeat (IR) sequences flanking the promoter sequence. The consensus sequence of these IRs was proposed as TAAYNNNDATTA (Y=C or T; D=A, G or T)...
  101. ncbi Additional dark G-band in the p-arm of chromosome 19 due to a paracentric inversion with a breakpoint in the pericentromeric heterochromatin
    C Fauth
    Institut für Anthropologie und Humangenetik, LMU Munchen, Goethestrasse 31, D 80336 Munich, Germany
    Am J Med Genet 103:160-2. 2001
    ..The rearranged chromosome segregated in two generations of a family without any phenotypic effects. A detailed characterization of the inv(19) by molecular cytogenetic techniques is presented...

Research Grants43

  1. GENOME FUNCTION IN MOUSE WITH COMBINATION MUTAGENESIS
    John Schimenti; Fiscal Year: 2009
    ..with ethylnitrosourea (ENU), and selecting those on proximal Chr 5 using a breeding scheme that exploited a chromosome inversion called rump-white (Rw)...
  2. An.gambiae immune signaling gene SNPs and natural P. falciparum infection
    Shirley Luckhart; Fiscal Year: 2013
    ..selected to include all of the genetic diversity known to exist in the region (three molecular forms and chromosome inversion polymorphism)...
  3. A Unique Natural Model for Studying the Mechanisms Underlying Social Behavior
    Donna L Maney; Fiscal Year: 2013
    ..Here, we will study these influences in an animal model with a natural polymorphism that provides a unique opportunity to characterize the processes underlying aggression and parenting. ..
  4. Identification of Candidate Genes at the Synapse in Autism Spectrum Disorders
    ABHA RANI GUPTA; Fiscal Year: 2013
    ..She will take full advantage of the resources of the Yale Child Study Center, an internationally recognized leader in the clinical evaluation and research of ASDs. ..
  5. Genetics of Anopheles funestus populations
    Nora Besansky; Fiscal Year: 2005
    ..funestus become possible ..
  6. STUDIES OF SPERM FUNCTION IN MAMMALIAN FERTILIZATION
    Patricia Olds Clarke; Fiscal Year: 2000
    ..Aim III is to determine whether this is so by determining the requirements for the abnormal protein tyrosine phosphorylation, and by mapping the defect to a specific region of the t complex. ..
  7. Identification of dyslexia susceptibility genes
    JACQUELINE DUVALL; Fiscal Year: 2006
    ..This information will be invaluable in aiding to elucidate the mechanisms underlying neurodevelopmental disorders involving language. ..
  8. MOUSE MODELS TO DELINEATE A UNIQUE METABOLIC AND SKELETAL NETWORK
    CLIFFORD JAMES ROSEN; Fiscal Year: 2010
    ..More importantly, this work could lead to a sea change in our general approach to identifying osteoporosis genes in mice and humans. ..
  9. ENZYMATIC MECHANISM OF HERPES VIRUS DNA REPLICATION
    I Lehman; Fiscal Year: 2007
    ..3. Cellular localization of endonuclease G pre- and post HSV-1 infection 4. Interaction of endonuclease G with other proteins. 5. Effect of suppression of endonuclease G on a-sequence-mediated recombination. ..
  10. CHROMOSOME 14 INVERSION IN HUMAN T CELL ONCOGENESIS
    Richard Baer; Fiscal Year: 1992
    ..The aim of this project is to determine how the inv(14)(q11;q32) chromosome inversion and the related t(14;14)(q11;q32) translocation contribute to the development of human T cell tumors...
  11. Molecular Markers: Response to Chemo-immunotherapy in C*
    John Byrd; Fiscal Year: 2005
    ..Such therapy would potentially administer different types of chemoimmunotherapy based upon the presence or absence of IgVH mutational status and p53 dysfunction. ..
  12. DEPSIPEPTIDE: A NOVEL HISTONE DEACYTLASE INHIBITOR IN L
    John Byrd; Fiscal Year: 2003
    ..The clinical and laboratory results of this trial will provide pharmacokinetic and pharmacodynamic information for additional correlative efforts in both single agent phase II and combination phase I studies. ..
  13. Epigenetic Targeted Therapy for Chronic Lymphocytic Leu*
    John Byrd; Fiscal Year: 2005
    ..abstract_text> ..
  14. A PHASE 1 Study of HuD10 IN CLL/SLL PATIENTS
    John Byrd; Fiscal Year: 2002
    ..These laboratory studies combined with clinical data derived from this trial will form the basis for future phase II development of this agent in CLL/SLL. ..
  15. Transcriptional and genic basis of incipient speciation
    Chung I Wu; Fiscal Year: 2008
    ..We expect to identify a number of candidate "speciation genes,* and will carry out precise gene replacement (Rong and Golic 2000; Greenberg et al. 2003) to confirm their effects on the mating behavior. ..
  16. The Role of SLITRK1 in Tourette and Related Disorders
    Matthew W State; Fiscal Year: 2010
    ..The purpose of this study is to better understand .what causes TD by identifying additional abnormalities in the SLITRK1 gene and by investigating the impact of these unusual genetic changes on the developing brain. ..
  17. Genetic Studies of African Anopheles Vectors of Malaria
    Jeffrey Powell; Fiscal Year: 2009
    ..Replacing natural vector populations with such strains require that the strain have high fitness. ..
  18. The repetitive DNA structure of the human genome
    PETER WARBURTON; Fiscal Year: 2009
    ..The studies proposed in this application will facilitate both computational and biological approaches to genomics and provide a unique analysis of a large and relatively neglected portion of our DNA sequence. ..
  19. ANALYSIS OF HUMAN CHROMOSOME 13Q NEOCENTROMERE FORMATION
    PETER WARBURTON; Fiscal Year: 2007
    ..Investigation of human centromere structure, function and formation will greatly facilitate the construction of artificial human chromosomes for use as autonomous gene expression vectors. ..
  20. MOLECULAR APPROACHES TO CHILDHOOD PSYCHIATRIC DISORDERS
    Matthew State; Fiscal Year: 2006
    ..abstract_text> ..
  21. 2003 Genetic Toxicology Gordon Conference
    Anthony Carr; Fiscal Year: 2007
    ..We particularly air to obtain funding to support applications from minority groupings and younger scientists. We have already identified a significant participation of women amongst our list of speakers. ..
  22. Pharmacologic modulation of chromatin remodeling in leu*
    Guido Marcucci; Fiscal Year: 2006
    ..Further, we believe that this schedule is amenable to future combination-based approaches. [unreadable] [unreadable]..
  23. E. COLI BASED VECTORS FOR GENE DELIVERY TO HUMAN CELLS
    PETER WARBURTON; Fiscal Year: 2002
    ..These studies propose to develop E. coli-based HAC vectors for human gene therapy that encompass novel approaches for gene delivery, accurate gene expression, and mitotic stability. ..
  24. BCI2 Antisense Against Chemoresistance in Elderly AML
    Guido Marcucci; Fiscal Year: 2003
    ..It is expected that the analysis of the clinical and correlative laboratory results will support testing of this combination in a phase III setting. ..
  25. Creation of mouse strains for the study of hematopoiesis
    Archibald Perkins; Fiscal Year: 2004
    ..The establishment of such strains will allow one to screen for mutants that have abnormal hematopoiesis. ..
  26. A 13q32 BAC Microarray for chromosome function analysis
    PETER WARBURTON; Fiscal Year: 2004
    ..The development of these types of high-density genomic microarrays will be a major step towards understanding the genomic organization and role of non-protein coding functional DNA elements in our cells. ..
  27. Ribonucleotide Reductase Antisense Strategy in AML
    Guido Marcucci; Fiscal Year: 2004
    ..It is expected that the analysis of these data will allow us to elucidate the intrinsic mechanisms of the antitumor activity of the antisense compounds and plan their incorporation in future therapeutic strategies for AML patients. ..
  28. Tetrahymena Genome Sequencing Project
    Jonathan Eisen; Fiscal Year: 2005
    ....
  29. Mutagenesis of the Mammalian Imprinting Process(es)
    Eugene Rinchik; Fiscal Year: 2002
    ..abstract_text> ..
  30. Molecular Cytogenetics and Tourette Disorder
    Matthew State; Fiscal Year: 2006
    ..abstract_text> ..
  31. E coli-based vectors for BAC delivery to mammalian cells
    PETER WARBURTON; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  32. Improving Bayesian Phylogeny
    Bret Larget; Fiscal Year: 2006
    ..abstract_text> ..
  33. Evolution of codon usage bias in the genus Drosophila
    Jeffrey Powell; Fiscal Year: 2009
    ..willistoni, one of the species being sequenced. ..
  34. Genetics/microsatellite instability in tumor suppressors
    Hanlee Ji; Fiscal Year: 2007
    ..To accomplish this goal, I will screen a cDNA library derived from normal colon tissue for new genes which are susceptible to microsatellite instability mutations. ..
  35. Stromal Stem Cells for Therapy of the Gangliosidoses
    Douglas Martin; Fiscal Year: 2004
    ..Kittens with the gangliosidoses will be evaluated for progression of neurological, hepatic and thymic disease. Mechanisms by which stem cell transplantation may alter the course of the gangliosidoses will be studied. ..
  36. "The Role of HDAC3 in Cardiac Growth and Development"
    Lazaros Kochilas; Fiscal Year: 2007
    ..They will also use selected molecular markers to dissect extracardiac processes relevant to cardiac development that are potentially affected in the hdac3 deficient embryos. [unreadable] [unreadable] [unreadable]..
  37. LARG, A Novel Leukemia Associated Guanine Exhange Factor
    Guido Marcucci; Fiscal Year: 2006
    ..i.). ..
  38. Molecular Epidemiology of Community-Associated MRSA
    SANJAY SHUKLA; Fiscal Year: 2008
    ..We will determine the presence or absence of 40 different virulence factor genes in all 320 isolates listed in aim 2 and determine evolution of virulence factor genes in contemporary CA-MRSA. ..
  39. MicroRNA evolution and species divergence in Drosophila
    Chung I Wu; Fiscal Year: 2010
    ..A survey of the scope of microRNA repertoire and their rise and fall through evolution will be useful for understanding their roles in regulating the normal and aberrant phenotypes in human populations. ..
  40. Neural Crest and Cardiac Outflow Tract Formation
    Lazaros Kochilas; Fiscal Year: 2004
    ..abstract_text> ..
  41. Hearing loss associated with chromosomal rearrangements
    Kerry Kocher; Fiscal Year: 2007
    ..Analysis of the mice and in situ hybridization studies of the candidate genes in the cochlea will be used to establish the role of these genes in auditory function. ..