chromosome defective micronuclei

Summary

Summary: Defective nuclei produced during the TELOPHASE of MITOSIS or MEIOSIS by lagging CHROMOSOMES or chromosome fragments derived from spontaneous or experimentally induced chromosomal structural changes.

Top Publications

  1. ncbi Cytogenetic comparison of the sensitivity to mutagens in mice selected for high (HA) and low (LA) swim stress-induced analgesia
    Mariusz Sacharczuk
    Department of Molecular Cytogenetics, Institute of Genetics and Animal Breeding of Polish Academy of Sciences in Jastrzêbiec, 05 556 Wolka Kosowska, Poland
    Mutat Res 535:95-102. 2003
  2. ncbi Micronuclei frequency in children exposed to environmental mutagens: a review
    Monica Neri
    Environmental Epidemiology and Biostatistics, National Cancer Research Institute, Largo R Benzi 10, 16132 Genoa, Italy
    Mutat Res 544:243-54. 2003
  3. ncbi Cytogenetic and oxidative damage induced in human lymphocytes by platinum, rhodium and palladium compounds
    Lucia Migliore
    Dipartimento di Scienze dell Uomo e dell Ambiente, University of Pisa, Via S Giuseppe 22, 56126 Pisa, Italy
    Mutagenesis 17:411-7. 2002
  4. ncbi Micronuclei as biomarkers of carcinogen exposure in populations exposed to arsenic through drinking water in West Bengal, India: a comparative study in three cell types
    Anamika Basu
    Division of Human Genetics and Genomics, Indian Institute of Chemical Biology, 4, Raja S C Mullick Road, Jadavpur, Calcutta 700 032, India
    Cancer Epidemiol Biomarkers Prev 13:820-7. 2004
  5. ncbi Enhanced frequency of micronuclei in individuals exposed to arsenic through drinking water in West Bengal, India
    A Basu
    Division of Human Genetics and Genomics, Indian Institute of Chemical Biology, 4, Raja S C Mullick Road, Calcutta 700032, West Bengal, India
    Mutat Res 516:29-40. 2002
  6. ncbi Analyses of micronuclei in exfoliated epithelial cells from individuals chronically exposed to arsenic via drinking water in inner Mongolia, China
    D Tian
    University of North Carolina, Chapel Hill, USA
    J Toxicol Environ Health A 64:473-84. 2001
  7. ncbi Evaluation of micronucleus induction in a Chilean population environmentally exposed to arsenic
    V Martinez
    Departament de Genetica i de Microbiologia, Grup de Mutagenesi, Facultat de Ciencies, Universitat Autonoma de Barcelona, Edifici Cn, Cerdanyola del Valles, Bellaterra 08193, Spain
    Mutat Res 564:65-74. 2004
  8. ncbi Low dose induction of micronuclei by lindane
    Olga I Kalantzi
    Department of Environmental Science, Lancaster University, Lancaster LA1 4YQ, UK
    Carcinogenesis 25:613-22. 2004
  9. ncbi Genetic damage detected in CD-1 mouse pups exposed perinatally to 3'-azido-3'-deoxythymidine and dideoxyinosine via maternal dosing, nursing, and direct gavage
    Jack B Bishop
    National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    Environ Mol Mutagen 43:3-9. 2004
  10. ncbi Recurrent chemical reactivations of EBV promotes genome instability and enhances tumor progression of nasopharyngeal carcinoma cells
    Chih Yeu Fang
    National Institute of Cancer Research, National Health Research Institutes, Zhunan, Taiwan
    Int J Cancer 124:2016-25. 2009

Research Grants

  1. Rapid Screen for Genotoxicants, Chemoprotectors, and Radioprotectors
    Stephen Dertinger; Fiscal Year: 2008
  2. High Throughput Radiation Biodosimetry
    Stephen Dertinger; Fiscal Year: 2007
  3. Measuring Cytogenetic Damage in Human Blood
    Stephen Dertinger; Fiscal Year: 2003
  4. Versatile Mutation Assay Platform
    Stephen Dertinger; Fiscal Year: 2007
  5. Automation of the vitro Micronucleus Assay
    Stephen Dertinger; Fiscal Year: 2004
  6. In vivo mutation assay based on pig-a locus
    Stephen Dertinger; Fiscal Year: 2004
  7. Molecular Biomarkers as Predictors of Hodgkin's Disease
    Randa El Zein; Fiscal Year: 2007
  8. HIGH ENERGY IONS AND GENOMIC INSTABILITY
    Eric Hall; Fiscal Year: 2001
  9. Cytochrome C Oxidase I:A Biomarker for Colon Cancer Risk
    Claire Payne; Fiscal Year: 2006
  10. Radioprotective Potential of Ginseng
    Tung Kwang Lee; Fiscal Year: 2006

Detail Information

Publications209 found, 100 shown here

  1. ncbi Cytogenetic comparison of the sensitivity to mutagens in mice selected for high (HA) and low (LA) swim stress-induced analgesia
    Mariusz Sacharczuk
    Department of Molecular Cytogenetics, Institute of Genetics and Animal Breeding of Polish Academy of Sciences in Jastrzêbiec, 05 556 Wolka Kosowska, Poland
    Mutat Res 535:95-102. 2003
    ..We conceive that the breeding strategy, along with the differentiation of stress-related phenomena, has altered the frequencies of genes controlling DNA repair in each line...
  2. ncbi Micronuclei frequency in children exposed to environmental mutagens: a review
    Monica Neri
    Environmental Epidemiology and Biostatistics, National Cancer Research Institute, Largo R Benzi 10, 16132 Genoa, Italy
    Mutat Res 544:243-54. 2003
    ..This review confirmed the usefulness of MN assay in biomonitoring studies conducted in children, revealing that in many circumstances investigating children increases the sensitivity of the study, even with low dose exposures...
  3. ncbi Cytogenetic and oxidative damage induced in human lymphocytes by platinum, rhodium and palladium compounds
    Lucia Migliore
    Dipartimento di Scienze dell Uomo e dell Ambiente, University of Pisa, Via S Giuseppe 22, 56126 Pisa, Italy
    Mutagenesis 17:411-7. 2002
    ..This work highlights the stronger genotoxicity, likely mediated by oxidative damage induction, of Pt and Rh compounds compared with Pd salts...
  4. ncbi Micronuclei as biomarkers of carcinogen exposure in populations exposed to arsenic through drinking water in West Bengal, India: a comparative study in three cell types
    Anamika Basu
    Division of Human Genetics and Genomics, Indian Institute of Chemical Biology, 4, Raja S C Mullick Road, Jadavpur, Calcutta 700 032, India
    Cancer Epidemiol Biomarkers Prev 13:820-7. 2004
    ....
  5. ncbi Enhanced frequency of micronuclei in individuals exposed to arsenic through drinking water in West Bengal, India
    A Basu
    Division of Human Genetics and Genomics, Indian Institute of Chemical Biology, 4, Raja S C Mullick Road, Calcutta 700032, West Bengal, India
    Mutat Res 516:29-40. 2002
    ..77, 0.56 and 0.53/1000 cells, respectively). Thus, the above results indicate that the symptomatic individuals exposed to arsenic through drinking water in this region have significant cytogenetic damage...
  6. ncbi Analyses of micronuclei in exfoliated epithelial cells from individuals chronically exposed to arsenic via drinking water in inner Mongolia, China
    D Tian
    University of North Carolina, Chapel Hill, USA
    J Toxicol Environ Health A 64:473-84. 2001
    ....
  7. ncbi Evaluation of micronucleus induction in a Chilean population environmentally exposed to arsenic
    V Martinez
    Departament de Genetica i de Microbiologia, Grup de Mutagenesi, Facultat de Ciencies, Universitat Autonoma de Barcelona, Edifici Cn, Cerdanyola del Valles, Bellaterra 08193, Spain
    Mutat Res 564:65-74. 2004
    ..In addition, as usually found in other human biomonitoring studies, sex and age are factors that modulate the frequency of MN in both exposed and reference populations...
  8. ncbi Low dose induction of micronuclei by lindane
    Olga I Kalantzi
    Department of Environmental Science, Lancaster University, Lancaster LA1 4YQ, UK
    Carcinogenesis 25:613-22. 2004
    ..These results suggest that 'environmental' concentrations of lindane can induce a number of subtle alterations in breast and prostate cells in the absence of cytotoxicity...
  9. ncbi Genetic damage detected in CD-1 mouse pups exposed perinatally to 3'-azido-3'-deoxythymidine and dideoxyinosine via maternal dosing, nursing, and direct gavage
    Jack B Bishop
    National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    Environ Mol Mutagen 43:3-9. 2004
    ..The amount of genetic damage observed in treated pups raises concern for the potential of similar damage in humans. Investigations of chromosomal integrity in exposed newborns and children are recommended...
  10. ncbi Recurrent chemical reactivations of EBV promotes genome instability and enhances tumor progression of nasopharyngeal carcinoma cells
    Chih Yeu Fang
    National Institute of Cancer Research, National Health Research Institutes, Zhunan, Taiwan
    Int J Cancer 124:2016-25. 2009
    ..These results suggest that recurrent EBV reactivations may result in accumulation of genome instability and promote the tumor progression of NPC...
  11. ncbi Micronucleated erythrocyte frequency in control and azidothymidine-treated Tk+/+, Tk+/- and Tk-/- mice
    Vasily N Dobrovolsky
    Division of Genetic and Reproductive Toxicology, U S Food and Drug Administration National Center for Toxicological Research, HFT 120, 3900 NCTR Rd, Jefferson, AR 72079, USA
    Mutat Res 570:227-35. 2005
    ..The elevated spontaneous MN frequencies in Tk-/- mice suggest the presence of an endogenous genotoxic activity in these mice...
  12. ncbi Genetic damage detected in CD-1 mouse pups exposed perinatally to 3'-azido-3'-deoxythymidine or dideoxyinosine via maternal dosing, nursing, and direct gavage: II. Effects of the individual agents compared to combination treatment
    Kristine L Witt
    National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    Environ Mol Mutagen 44:321-8. 2004
    ..Comparison of micronucleated cell frequencies induced by AZT alone or in combination with ddI suggests that ddI potentiates AZT-induced chromosomal damage following direct exposure...
  13. ncbi Association of maternal polymorphisms in folate metabolizing genes with chromosome damage and risk of Down syndrome offspring
    Fabio Coppede
    Department of Neuroscience, University of Pisa, Pisa, Italy
    Neurosci Lett 449:15-9. 2009
    ..0001) and, in the total population, a significant correlation between micronucleated cells and both MTHFR 677C>T (P=0.031) and 1298A>C (P=0.047) polymorphisms...
  14. ncbi Epstein-Barr virus nuclear antigen 2 disrupts mitotic checkpoint and causes chromosomal instability
    Shih Hsuan Pan
    Graduate Institute of Microbiology, College of Medicine, National Taiwan University, Taipei 100, Taiwan
    Carcinogenesis 30:366-75. 2009
    ..Together, these studies reveal a new function of EBNA2 in cell-cycle regulation and may shed light on the role of EBNA2 in EBV-mediated tumorigenesis...
  15. ncbi Epstein-Barr virus latent membrane protein 1 induces micronucleus formation, represses DNA repair and enhances sensitivity to DNA-damaging agents in human epithelial cells
    Ming Tsan Liu
    National Health Research Institutes, 3F No 109, Section 6, Min Chuan East Road, Taipei 114, Taiwan
    Oncogene 23:2531-9. 2004
    ..Based on these results, we suggest that disruption of DNA repair by LMP-1 results in an accumulation of unrepaired DNA and consequent genomic instability, which may contribute to the oncogenesis of LMP1 in human epithelial cells...
  16. ncbi Oestrogens induce G(1) arrest in benzo[a]pyrene-treated MCF-7 breast cells whilst enhancing genotoxicity and clonogenic survival
    Cordula Davis
    Department of Biological Sciences, IENS, Lancaster University, Lancaster LA1 4YQ, UK
    Mutagenesis 17:431-8. 2002
    ..This work suggests that whilst oestrogens appear to enhance carcinogen-induced DNA damage, they also appear, paradoxically, to trigger mechanisms that facilitate clonogenic survival, which may be relevant to breast cancer initiation...
  17. ncbi Polymorphisms in folate and homocysteine metabolizing genes and chromosome damage in mothers of Down syndrome children
    Fabio Coppede
    Department of Neurosciences, University of Pisa, Pisa, Italy
    Am J Med Genet A 143:2006-15. 2007
    ....
  18. ncbi Effect of dietary intake of vitamin A or E on the level of DNA damage, chromosomal aberrations, and micronuclei induced in freshly isolated rat hepatocytes by different carcinogens
    Darina Slamenova
    Cancer Research Institute, Slovak Academy of Sciences, 833 91 Bratislava, Slovak Republic
    Nutr Cancer 42:117-24. 2002
    ..Both vitamins reduced the level of DNA strand breaks induced by the oxidative effect of a visible light-excited photosensitizer...
  19. ncbi Micronuclei assessment in buccal cells of people environmentally exposed to arsenic in northern Chile
    V Martinez
    Grup de Mutagenesi, Departament de Genetica i de Microbiologia, Edifici Cn, Universitat Autonoma de Barcelona, 08193 Bellaterra, Cerdanyola del Valles, Spain
    Toxicol Lett 155:319-27. 2005
    ..As a conclusion it appears that, in the studied population, the chronic ingestion of arsenic-contaminated water does not induce cytogenetic damage, measured as micronuclei, in the cells of the oral mucous in a significant extent...
  20. pmc In vivo elimination of acentric double minutes containing amplified MYCN from neuroblastoma tumor cells through the formation of micronuclei
    A Valent
    Laboratoire de Génomique Cellulaire des Cancers Centre National de la Recherche Scientifique Unité Mixte de Recherche, Villejuif, France
    Am J Pathol 158:1579-84. 2001
    ..Because the elimination of amplified sequences can be enhanced in vitro by specific drugs such as hydroxyurea, our observations suggest a new therapeutic strategy specifically targeted to cells with amplified genes...
  21. ncbi Radiation effects in lymphocytes of children living in a Chernobyl contaminated region of Belarus
    L S Mikhalevich
    Institute of Genetics and Cytology, National Academy of Sciences of Belarus, Minsk
    Int J Radiat Biol 76:1377-85. 2000
    ..To investigate cytogenetic and mutational effects in lymphocytes from individuals chronically exposed to radiation from the Chernobyl catastrophe...
  22. pmc Association of HSP70 and genotoxic damage in lymphocytes of workers exposed to coke-oven emission
    Chengfeng Xiao
    Institute of Occupational Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, People s Republic of China
    Cell Stress Chaperones 7:396-402. 2002
    ..05). Our results show that individuals who had high Hsp70 levels generally showed lower genotoxic damage than others. These results suggest a role of Hsp70 in the protection of DNA from genotoxic damage induced by coke-oven emission...
  23. ncbi Studies of bystander effects in human fibroblasts using a charged particle microbeam
    K M Prise
    Gray Laboratory Cancer Research Trust, Mount Vernon Hospital, Northwood, Middlesex, UK
    Int J Radiat Biol 74:793-8. 1998
    ..To determine the role of cell-to-cell mediated effects in the response of cells to different radiations by using a charged particle microbeam capable of targeting individual cells with counted particles...
  24. ncbi Correlation between cell survival, clonogenic activity and micronuclei induction in DMBA-OC-1R cells treated with immunospecific albumin microspheres containing cisplatin and 5-fluorouracil
    Ernest J Truter
    Faculty of Applied Sciences, Cape Technikon, Cape Town, South Africa
    Cell Biol Int 26:505-16. 2002
    ....
  25. pmc Human inter-individual variability in metabolism and genotoxic response to zidovudine
    Ofelia A Olivero
    Carcinogen DNA Interactions Section, Laboratory of Cancer Biology and Genetics, National Cancer Institute, National Institutes of Health, 37 Convent Drive, Bethesda, MD 20892 4255, USA
    Toxicol Appl Pharmacol 228:158-64. 2008
    ..These data suggest that variability in AZT-DNA incorporation may be modulated by inter-individual differences in the rate of induction of TK1 in response to AZT exposure...
  26. ncbi Micronuclei induction and chromosomal aberrations in Rattus norvegicus by chloroacetic acid and chlorobenzene
    Mohammad Faisal Siddiqui
    Section of Genetics, Department of Zoology, Aligarh Muslim University, Aligarh 202002, Uttar Pradesh, India
    Ecotoxicol Environ Saf 65:159-64. 2006
    ..Most significant impact (P<0.05) for either of the compounds was observed at 24h post administration, when the recorded mean frequency of CAs was maximum for CAA (4.33+/-0.6) as well as for CB (4.66+/-0.5)...
  27. ncbi Occupational exposure in airport personnel: characterization and evaluation of genotoxic and oxidative effects
    Delia Cavallo
    Department of Occupational Medicine, ISPESL National Institute for Occupational Safety and Prevention, Via Fontana Candida 1, 00040 Monteporzio Catone, Rome, Italy
    Toxicology 223:26-35. 2006
    ....
  28. ncbi Absence of genotoxicity in human blood cells exposed to 50 Hz magnetic fields as assessed by comet assay, chromosome aberration, micronucleus, and sister chromatid exchange analyses
    L Stronati
    Section of Toxicology and Biomedical Sciences, ENEA CR, Casaccia, Rome, Italy
    Bioelectromagnetics 25:41-8. 2004
    ..Moreover, no synergistic effect with ionizing radiation has been observed. A slight but significant decrease of cell proliferation was evident in ELFMFs treated samples and samples subjected to the combined exposure...
  29. ncbi DNA damage, oxidative mutagen sensitivity, and repair of oxidative DNA damage in nonmelanoma skin cancer patients
    Andres Bendesky
    Instituto de Investigaciones Biomedicas, Universidad Nacional Autonoma de Mexico, Mexico DF, Mexico
    Environ Mol Mutagen 47:509-17. 2006
    ..The results of this study indicate that NMSC patients are distinguished from controls by an increased sensitivity to oxidative DNA damage...
  30. ncbi Evaluation of antimutagenic activity and mechanisms of action of beta-glucan from barley, in CHO-k1 and HTC cell lines using the micronucleus test
    Rodrigo Juliano Oliveira
    Departamento de Biologia Geral, Universidade Estadual de Londrina UEL, Londrina PR, Brazil
    Toxicol In Vitro 20:1225-33. 2006
    ....
  31. ncbi Genotoxic evaluation of workers employed in pesticide production
    N Sailaja
    Toxicology Unit, Biology Division, Indian Institute of Chemical Technology, Hyderabad 500007, Andhra Pradesh, India
    Mutat Res 609:74-80. 2006
    ..05). Our findings indicate that occupational exposure to pesticides could cause genome damage in somatic cells...
  32. ncbi DNA damage by bromate: mechanism and consequences
    Daniel Ballmaier
    Institute of Pharmacy, University of Mainz, D 55099 Mainz, Germany
    Toxicology 221:166-71. 2006
    ....
  33. ncbi Chromosomal aberrations in Crepis capillaris cells detected by FISH
    Jolanta Maluszynska
    Department of Plant Anatomy and Cytology, University of Silesia, Katowice, Poland
    Folia Histochem Cytobiol 41:101-4. 2003
    ..We demonstrate a few examples of the detection of chromosomal aberrations using rDNA and telomeric sequences as probes for in situ hybridization to C. capillaris chromosomes...
  34. ncbi Cytogenetic effects of hexavalent chromium in Bulgaria
    A K Nersesyan
    Mutat Res 538:181-2; author reply 183-4. 2003
  35. ncbi Analysis of mutations and bone marrow micronuclei in Big Blue rats fed leucomalachite green
    M G Manjanatha
    Food and Drug Administration, National Center for Toxicological Research, 3900 NCTR Road, Jefferson, AR 72079, USA
    Mutat Res 547:5-18. 2004
    ....
  36. ncbi Genotoxicity of acrylamide and its metabolite glycidamide administered in drinking water to male and female Big Blue mice
    Mugimane G Manjanatha
    Division of Genetic and Reproductive Toxicology, US FDA National Center for Toxicological Research, Jefferson, Arkansas 72079, USA
    Environ Mol Mutagen 47:6-17. 2006
    ..The results indicate that both AA and GA are genotoxic in mice. The MFs and types of mutations induced by AA and GA in the liver are consistent with AA exerting its genotoxicity in BB mice via metabolism to GA...
  37. ncbi Protective effect of apigenin on radiation-induced chromosomal damage in human lymphocytes
    Kanokporn Noy Rithidech
    Pathology Department, State University of New York at Stony Brook, Stony Brook, NY 11794 8691, USA
    Mutat Res 585:96-104. 2005
    ..These findings provide a basis for additional studies to help clarify the potential use and benefit of apigenin as a radioprotector...
  38. ncbi [Estimation of potential mutagenic activity of 24-epibrassinolide]
    A M Voitovich
    Tsitol Genet 38:49-53. 2004
    ....
  39. ncbi Effect of sulforaphane on micronucleus induction in cultured human lymphocytes by four different mutagens
    Carmela Fimognari
    Department of Pharmacology, University of Bologna, Bologna, Italy
    Environ Mol Mutagen 46:260-7. 2005
    ..Taken together, our findings indicate that under certain conditions sulforaphane possesses anti-genotoxic activity in vitro and that further studies are warranted to characterize this property in vivo...
  40. ncbi Assessment of the in vivo genotoxicity of vanadate: analysis of micronuclei and DNA damage induced in mice by oral exposure
    Paola Leopardi
    Genetic Toxicology Unit, Department of Environment and Primary Prevention, Istituto Superiore di Sanita, Viale Regina Elena, 299, 00161 Rome, Italy
    Toxicol Lett 158:39-49. 2005
    ..Overall, the results obtained indicate that the genotoxic activity of pentavalent vanadium is expressed in vivo only following high dose exposure, possibly as a consequence of the poor bioavailability of the element...
  41. ncbi In vitro assessment of the genotoxicity of ethyl paraoxon in newborns and adults
    K Islas-González
    Laboratorio de Biotecnologia, Facultad de Ciencias Quimicas, Universidad Autonoma de Chihuahua, Mexico
    Hum Exp Toxicol 24:319-24. 2005
    ..In conclusion, our study identified primary DNA damage due to ethyl paraoxon, with a major effect on newborn lymphocytes, as well as an effect on the frequency of MN in the study groups at high concentrations only...
  42. ncbi Micronucleus frequency in human umbilical cord lymphocytes
    M Levario-Carrillo
    Unidad de Investigacion Medica en Epidemiologia Clinica, Instituto Mexicano del Seguro Social IMSS, Chihuahua, Mexico
    Mutat Res 586:68-75. 2005
    ..01) higher frequency of MN (4+/-2) was found only in lymphocytes from NB from high-risk pregnancies. Data indicate that MN evaluation in umbilical cord samples might be useful in the identification of transplacental mutagens...
  43. ncbi Acrylamide and glycidamide: genotoxic effects in V79-cells and human blood
    Matthias Baum
    Division of Food Chemistry and Environmental Toxicology, Department of Chemistry, University of Kaiserslautern, D 67663 Kaiserslautern, Germany
    Mutat Res 580:61-9. 2005
    ..Thus, in our systems GA appears to exert a rather moderate genotoxic activity...
  44. ncbi Nodularin-induced genotoxicity following oxidative DNA damage and aneuploidy in HepG2 cells
    A Lankoff
    Department of Radiobiology and Immunology, Institute of Biology, Swietokrzyska Academy, Swietokrzyska 15, 25 406 Kielce, Poland
    Toxicol Lett 164:239-48. 2006
    ..These results suggest a causative role for nodularin in the process leading to the accumulation of genetic alterations which may be implicated in carcinogenesis...
  45. ncbi Mutagenic effects of chromium trioxide on root tip cells of Vicia faba
    Xiao Wei Qian
    School of Life and Environmental Science, Wenzhou Normal College, Wenzhou 325003, China
    J Zhejiang Univ Sci 5:1570-6. 2004
    ..We concluded that CrO(3) has significant mutagenic effect on Vicia faba root tip cells...
  46. ncbi Antimutagenic effect of neem leaves extract in freshwater fish, Channa punctatus evaluated by cytogenetic tests
    M Abul Farah
    Gene Tox Lab, Section of Genetics, Department of Zoology, Aligarh Muslim University, Aligarh 202002, India
    Sci Total Environ 364:200-14. 2006
    ..Results suggested that under present experimental conditions, neem extract exhibit strong antimutagenic activity in this fish model, which could further contribute to study its benefit in humans...
  47. ncbi [The frequency of micronuclei in lymphocytes from cord blood as a marker of exposure to mutagenic factors]
    Agata Piestrzyńska
    Zakład Antropologii, Instytut Zoologii, Uniwersytet Jagielloński w Krakowie
    Przegl Lek 61:244-7. 2004
    ..Significant difference between mother's and neonate's frequencies of micronuclei indicates on less exposure to genotoxic factors of neonates...
  48. ncbi Genotoxicity and cytotoxicity assessment in lake drinking water produced in a treatment plant
    Annamaria Buschini
    Dipartimento di Genetica Antropologia Evoluzione, Universita di Parma, Parco Area delle Scienze 11A, 43100 Parma, Italy
    Mutagenesis 19:341-7. 2004
    ....
  49. ncbi Genotoxic damage in female residents exposed to environmental air pollution in Shenyang city, China
    Hitoshi Ishikawa
    Department of Public Health and Occupational Medicine, Mie University Graduate School of Medicine, Edobashi 2 174, Tsu 514 8507, Japan
    Cancer Lett 240:29-35. 2006
    ..These results provide evidence that micronuclei assays are a sensitive indicator to air pollution-induced genotoxic effects in humans...
  50. ncbi Investigation of genotoxic effect of ultrasound in cases receiving therapeutic ultrasound by using micronucleus method
    Ozlem Sahin
    Abant Izzet Baysal University, Izzet Baysal Medical Faculty, Department of Physican Medicine and Rehabilitation, Bolu, Turkey
    Ultrasound Med Biol 30:545-8. 2004
    ..In conclusion, we observed that therapeutic US did not induce increases in MN frequency, which are a sign of cytogenetic damage...
  51. ncbi Chromosomal aberrations and frequency of micronuclei in sheep subchronically exposed to the fungicide Euparen Multi (tolylfluanid)
    Irena Sutiaková
    University of Veterinary Medicine, Komenskeho 73, 041 81 Kosice, Slovak Republic
    Ecotoxicol Environ Saf 64:312-20. 2006
    ..0477). No statistical differences in MI and NDI values were found in the groups (P = 0.181 and 0.761, respectively). Thus, our results suggest that exposure to Euparen Multi may cause genome damage in somatic cells...
  52. ncbi Ameliorative effects of vitamin supplementation on ethyl methane sulphonate-induced genotoxicity in a fish, Anabas testudineus
    Bibhas Guha
    Cytogenetics and Molecular Biology Laboratory, Department of Zoology, University of Kalyani, Kalyani 741235, West Bengal, India
    Ecotoxicol Environ Saf 68:63-70. 2007
    ..The results of this study can lead to future research for exploring if low doses of these vitamins may be useful in protecting fish from genotoxic damage on exposure to mutagenic agents in small confined/stagnant waters...
  53. ncbi Biomonitoring of primary aluminium industry workers: detection of micronuclei and repairable DNA lesions by alkaline SCGE
    Riccardo Crebelli
    Laboratory of Comparative Toxicology and Ecotoxicology, Istituto Superiore di Sanita, Viale Regina Elena 299, I 00161 Rome, Italy
    Mutat Res 516:63-70. 2002
    ....
  54. ncbi Relationship between radiation induced dicentric chromosome aberrations and micronucleus formation in human lymphocytes
    S E Hatayoglu
    Istanbul University, Faculty of Science, Department of Biology, Istanbul, Turkey
    J Exp Clin Cancer Res 26:229-34. 2007
    ....
  55. ncbi Genotoxicity assessment in oncology nurses handling anti-neoplastic drugs
    P V Rekhadevi
    Toxicology Unit, Biology Division, Indian Institute of Chemical Technology, Hyderabad 500 007, Andhra Pradesh, India
    Mutagenesis 22:395-401. 2007
    ..This data corroborate the need to maintain safety measures to avoid exposure and the necessity of intervention in the case of exposure when using and handling anti-neoplastic drugs...
  56. ncbi Induction of micronuclei in human cell lines and primary cells by combination treatment with gamma-radiation and ethyl methanesulfonate
    Helga Stopper
    Department of Toxicology, University of Wurzburg, Versbacher Strasse 9, D 97078 Wurzburg, Germany
    Mutagenesis 17:177-81. 2002
    ..It is concluded that caution is advised in the interpretation and extrapolation of experimental results of mixture toxicity data because the outcome could be highly specific for the given selection of agents, doses and assays...
  57. ncbi Biomarkers to assess the genetic damage induced by alcohol abuse in human lymphocytes
    Francesca Maffei
    Department of Pharmacology, University of Bologna, 40126, Bologna, Italy
    Mutat Res 514:49-58. 2002
    ..They could be included in programs for cancer prevention in alcoholics. Abstinence appears to normalize the frequency of both MN and CA. This could offer therapists another tool to help alcoholics change their lifestyle...
  58. ncbi Cytogenetic effects of hexavalent chromium in Bulgarian chromium platers
    Donka Benova
    National Center of Radiobiology and Radiation Protection NCRRP, Laboratory of Radiation Mutagenesis and Embryology, 132 Kliment Ochridski Blvd, 1756, Sofia, Bulgaria
    Mutat Res 514:29-38. 2002
    ..No difference between C(+) and C(-) MN frequencies was found in the lymphocytes as well as in the buccal cells. Thus, Cr(VI) appears to have both clastogenic as well as aneugenic effects in humans...
  59. ncbi Parthenin, a sesquiterpene lactone of Parthenium hysterophorus L. is a high toxicity clastogen
    Alberto Ramos
    Centro de Investigación y Desarrollo de Medicamentos, Ave 26 No 1605, Ciudad de La Habana, CP 10 600, Havana, Cuba
    Mutat Res 514:19-27. 2002
    ..When a single intraperitoneal (i.p.) dose of 4-31 mg/kg of parthenin was administered to mice, a positive increase in the micronucleated reticulocyte (RET) frequency was observed at 48 h for both sexes at the highest dose...
  60. ncbi Radiofrequency electromagnetic fields (UMTS, 1,950 MHz) induce genotoxic effects in vitro in human fibroblasts but not in lymphocytes
    Claudia Schwarz
    Division of Occupational Medicine, Medical University of Vienna, Waehringer Guertel 18 20, 1090, Vienna, Austria
    Int Arch Occup Environ Health 81:755-67. 2008
    ..This is discomforting, because genotoxic effects of the second generation standard Global System for Mobile Communication have been reported after exposure of human cells in vitro...
  61. ncbi Genotoxic effects of p,p'-DDT (1,1,1-trichloro-2,2-bis-(chlorophenyl)ethane) and its metabolites in Zebra mussel (D. polymorpha) by SCGE assay and micronucleus test
    Andrea Binelli
    Department of Biology, University of Milan, Via Celoria 26, Milan, Italy
    Environ Mol Mutagen 49:406-15. 2008
    ..A greater genotoxic potential of the p,p'-DDE with respect to the other two chemicals was revealed...
  62. ncbi Titanium dioxide nanoparticles trigger p53-mediated damage response in peripheral blood lymphocytes
    Su Jin Kang
    School of Public Health and Institute of Health and Environment, Seoul National University, Seoul, Korea
    Environ Mol Mutagen 49:399-405. 2008
    ..Given that ROS-induced DNA damage leads to p53 activation in the DNA damage response, our results suggest that nano-TiO2 induces ROS generation in lymphocytes, thereby activating p53-mediated DNA damage checkpoint signals...
  63. ncbi Quercetin ameliorates gamma radiation-induced DNA damage and biochemical changes in human peripheral blood lymphocytes
    Nagarajan Devipriya
    Department of Biochemistry and Biotechnology, Faculty of Science, Annamalai University, Annamalainagar 608002, Tamil Nadu, India
    Mutat Res 654:1-7. 2008
    ..Altogether, our findings encourage further mechanistic and in vivo studies to investigate radioprotective efficacy of QN...
  64. ncbi Genotoxic effects of fumes from asphalt modified with waste plastic and tall oil pitch
    Hanna K Lindberg
    New Technologies and Risks, Work Environment Development, Finnish Institute of Occupational Health, FI 00250 Helsinki, Finland
    Mutat Res 653:82-90. 2008
    ..Our results indicate that fumes from SMA and SMA-WPT contain direct-acting genotoxic components...
  65. ncbi Cytotoxic and genotoxic effects of tambjamine D, an alkaloid isolated from the nudibranch Tambja eliora, on Chinese hamster lung fibroblasts
    Bruno C Cavalcanti
    Departamento de Fisiologia e Farmacologia, Faculdade de Medicina, Universidade Federal do Ceara, CEP 60430 270 Fortaleza, CE, Brazil
    Chem Biol Interact 174:155-62. 2008
    ..Tambjamine D, also, induced DNA strand breaks and increased the micronucleus cell frequency as evaluated by comet and micronucleus tests, respectively, at all concentrations evaluated, showing a genotoxic risk induced by tambjamine D...
  66. ncbi Cytogenetic analysis of tannery workers in Morocco
    A Hilali
    Université Hassan I, Faculty of Sciences and Technics, Settat, km 3, Route de Casablanca, BP 577 26000 Settat Marocco
    J Appl Toxicol 28:439-42. 2008
    ..It was shown that the frequencies of cells with chromosome aberrations and micronuclei were significantly increased in the lymphocytes of the workers compared with the frequencies found in an unexposed control population...
  67. ncbi Micronuclei, nucleoplasmic bridges and nuclear buds induced in folic acid deficient human lymphocytes-evidence for breakage-fusion-bridge cycles in the cytokinesis-block micronucleus assay
    Michael Fenech
    CSIRO Health Sciences and Nutrition, Genomic Stability Project, P O Box 10041, Adelaide BC, Australia
    Mutat Res 504:131-6. 2002
    ..These results also suggest that the CBMN assay may be a useful model for the study of the BFB cycle which may be one of the key mechanisms for the hypermutability phenotype required for the rapid evolution of cancer cells...
  68. ncbi Effects of ochratoxin A on micronucleus frequency in human lymphocytes
    Hamiyet Donmez-Altuntas
    Erciyes University, Medical Faculty, Department of Medical Biology, Kayseri, Turkey
    Nahrung 47:33-5. 2003
    ..OTA at the other concentrations tested did not induce MN frequency. These results indicate that a high concentration of OTA is genotoxic in cultured human lymphocytes...
  69. ncbi Increased cytogenetic damage in a zone in transition from agricultural to industrial use: Comprehensive analysis of the micronucleus test in peripheral blood lymphocytes
    Regina Montero
    Instituto de Investigaciones Biomedicas, Universidad Nacional Autónoma de México México City, DF, Mexico
    Mutagenesis 21:335-42. 2006
    ..Further characterization of the exposure regimes in these communities will be done in order to contribute to the alleviation of the health risks that environmental pollution is posing on the inhabitants of this area...
  70. ncbi Ascorbic acid potentiates mitomycin C-induced micronuclei and sister chromatid exchanges in human peripheral blood lymphocytes in vitro
    A P Krishnaja
    Genetic Toxicology and Chromosome Studies Section, Cell Biology Division, Bhabha Atomic Research Centre, Mumbai, India
    Teratog Carcinog Mutagen . 2003
    ..The potentiation observed has to be viewed in the light of metal ion catalysed autooxidation of AA in oxygenated media and the existence of an antioxidant system in vivo that inactivates oxyradicals before their interaction with DNA...
  71. ncbi [Induction of chromosome aberrations and micronuclei in human peripheral blood lymphocytes at low dose of radiation]
    N L Shmakova
    Radiats Biol Radioecol 46:480-7. 2006
    ..Preferences and disadvantages of used cytogenetic assays and possible mechanisms of low ionising radiation doses action were discussed...
  72. ncbi Induction of micronuclei by alkaloids extracted from Senecio brasiliensis and stored for 23 years
    R Santos-Mello
    Laboratório de Mutagênese, Universidade Luterana do Brasil, Rua Miguel Tostes 101 Bairro St Luís, Prédio 19 Sala 208, 92420 280 Canoas, RS, Brazil
    Mutat Res 516:23-8. 2002
    ..However, an antimitotic effect was observed...
  73. ncbi Inhibitory effect of chlorophyllin on the frequency of micronuclei induced by sodium nitrite in mice
    S Diaz-Barriga Arceo
    Laboratorio de Citogenética FESC UNAM, Escuela Nacional de Ciencias Biologicas, Instituto Politecnico Nacional, Mexico
    Phytother Res 16:754-7. 2002
    ..Our study produced two main results: (a) no bone marrow injury was induced by any of the tested chemicals, as indicated with the PE/NE index, and (b) CHL protected (as high as 44%) the MNPE produced in nitrite treated mice...
  74. ncbi Assessment of genome damage in a population of Croatian workers employed in pesticide production by chromosomal aberration analysis, micronucleus assay and Comet assay
    Vera Garaj-Vrhovac
    Institute for Medical Research and Occupational Health, Laboratory for Mutagenesis, Ksaverska 2, 10000 Zagreb, Croatia
    J Appl Toxicol 22:249-55. 2002
    ..001) increase in DNA migration. Results suggest that long-term occupational exposure to pesticides could cause genome damage in somatic cells and therefore may represent a potential hazard to human health...
  75. ncbi Arsenite-induced alterations in Ku70-deficient cells: a model to study genotoxic effects
    Qi zhan Liu
    Department of Molecular Cell Biology and Toxicology, School of Public Health, Nanjing Medical University, Nanjing, Jiangsu, People s Republic of China
    J Toxicol Environ Health A 70:938-46. 2007
    ..These results suggested that Ku70 protein plays an important role in repair of DNA DSB damage and for maintainance of genome stability...
  76. ncbi Cytogenetic evaluation of paracetamol effects in human lymphocytes culture
    Slavka Ibrulj
    Institute for Genetic Engineering and Biotechnology, University of Sarajevo, Bosnia and Herzegovina
    Drug Chem Toxicol 30:133-43. 2007
    ..Results demonstrate that paracetamol concentration of 200 microg/mL expresses certain genotoxic effects in human peripheral blood lymphocytes...
  77. ncbi Acentromeric micronuclei are increased in peripheral blood lymphocytes of untreated cancer patients
    M Baciuchka-Palmaro
    Laboratoire de biogénotoxicologie et mutagenèse environnementale EA 1784 IFR PMSE 112, Facultes de Medecine et de Pharmacie, Universite de la Mediterranee, 27 Bd Jean Moulin, 13385 cedex 05, Marseille, France
    Mutat Res 520:189-98. 2002
    ..However, a substantial proportion of this genetic instability occurs because of defects in chromosome segregation...
  78. ncbi Investigating the genetic instability in the peripheral lymphocytes of 36 untreated lung cancer patients with comet assay and micronucleus assay
    Jianlin Lou
    Zhejiang University, Medical College, Institute of Environmental Medicine, Hangzhou 310058, Zhejiang, People s Republic of China
    Mutat Res 617:104-10. 2007
    ..05). The results of present investigation indicated that the genetic instability in peripheral lymphocytes of 36 lung cancer patients was significantly higher than that of controls...
  79. ncbi Genotoxic biomonitoring study of population residing in pesticide contaminated regions in Göksu Delta: micronucleus, chromosomal aberrations and sister chromatid exchanges
    Serap Ergene
    Department of Biology, Faculty of Science and Letters, Mersin University, Mersin, Turkey
    Environ Int 33:877-85. 2007
    ..Also smoking and exposure affected the frequency of sister chromatid exchange and chromosomal aberrations compared with control groups...
  80. pmc Biomonitoring of DNA damage and cytotoxicity in individuals exposed to cone beam computed tomography
    V Carlin
    Departament of Pathology, Paulista Medical School, Federal University of Sao Paulo, UNIFESP, SP, Brazil
    Dentomaxillofac Radiol 39:295-9. 2010
    ..The aim of the present study was to evaluate DNA damage (micronucleus) and cellular death (pyknosis, karyolysis and karyorrhexis) in exfoliated buccal mucosa cells from adults following cone beam CT exposure...
  81. ncbi The yield of radiation-induced micronuclei in early and late-arising binucleated cells depends on radiation quality
    Christian Johannes
    Department of Genetics, University of Duisburg Essen, Germany
    Mutat Res 701:80-5. 2010
    ..Some individual variability was detected and the conflicting results regarding the relationship between the yield of cytogenetic damage and lymphocyte culture time can, at least partly, be due to this variability...
  82. ncbi Patulin-induced genotoxicity and modulation of glutathione in HepG2 cells
    Si min Zhou
    Department of Toxicology, Dalian Medical University, No 9, West Segment of South Ivshun Road, Dalian 116044, China
    Toxicon 53:584-6. 2009
    ..19-0.75 microM). These results indicate that GSH play an important role in cellular defense against PAT-induced genotoxicity...
  83. ncbi Cytogenetic effects of 8-Cl-cAMP on human and animal chromosomes
    V Bajic
    Institute for Pharmaceutical Research, Galenika, Belgrade, Serbia
    J BUON 14:71-7. 2009
    ..To assess the cytogenetic effects in vitro and in vivo of a non-cytotoxic antitumor agent with biomodulator activity, 8-chloro-3',5' cyclic adenosine monophosphate (8-ClcAMP)...
  84. ncbi Phytotoxic, clastogenic and bioaccumulation effects of the environmental endocrine disruptor bisphenol A in various crops grown hydroponically
    Giuseppe Ferrara
    Dipartimento di Scienze delle Produzioni Vegetali, University of Bari, Via Amendola 165 A, 70126 Bari, Italy
    Planta 223:910-6. 2006
    ..The number of MN in broad bean and durum wheat root tip cells increased markedly by treatment with BPA at both concentrations, thus suggesting a potential clastogenic activity of BPA in these species...
  85. ncbi Evaluation of the potential genotoxicity of chromium picolinate in mammalian cells in vivo and in vitro
    Maria A Andersson
    Department of Pharmaceutical Biosciences, Division of Toxicology, Box 594, Uppsala University, SE 751 24 Uppsala, Sweden
    Food Chem Toxicol 45:1097-106. 2007
    ..Taken together, our results suggest that a high concentration of CrPic might be DNA damaging, but only under non-physiological conditions...
  86. ncbi Investigating genetic damage in workers occupationally exposed to methotrexate using three genetic end-points
    Hongping Deng
    Zhejiang University, Medical College, Institute of Occupational and Environmental Health, Hangzhou 310006, Zhejiang, People s Republic of China
    Mutagenesis 20:351-7. 2005
    ..52 x 10(-4) and 1.67 +/- 0.14 x 10(-4), respectively, which were significantly different (P < 0.01). The results of our experiment suggest that genetic damage is detectable in the 21 workers occupationally exposed to methotrexate...
  87. ncbi Microsporogenesis in sexual Brachiaria hybrids (Poaceae)
    V A Fuzinatto
    Departamento de Biologia Celular e Genetica, Universidade Estadual do Maringá, Maringa, PR, Brasil
    Genet Mol Res 6:1107-17. 2007
    ..They may be used in crosses to generate new cultivars in the future...
  88. ncbi Confirmation of the chromosome damaging effects of lamivudine in in vitro human peripheral blood lymphocytes
    Suleyman Bayram
    Department of Biology, Natural and Applied Science Institute, Cukurova University, Adana, Turkey
    Environ Mol Mutagen 49:328-33. 2008
    ..In conclusion, lamivudine has a weak genotoxic effect at elevated doses on human peripheral lymphocytes...
  89. ncbi Hemoglobin adducts and micronuclei in rodents after treatment with isoprene monoxide or butadiene monoxide
    Charlotta Fred
    Department of Environmental Chemistry, Stockholm University, SE 106 91 Stockholm, Sweden
    Mutat Res 585:21-32. 2005
    ....
  90. ncbi About some physical mechanisms of statistics of radiation-induced effects formation and non-linear cell response in low dose area
    V Rusov
    Department of Theoretical and Experimental Nuclear Physics, Odessa Polytechnic University, Shevchenko av I, Odessa 65044, Ukraine
    Radiat Meas 34:105-8. 2001
    ..For the first time, a new determination of the relative biological efficiency and quality coefficient of ionizing radiation in area of low doses are proposed...
  91. ncbi Purine receptor agonists protect the genome of plant and animal cells from clastogen damage
    V S Kharitonov
    Kazan State Medical University Kazan State University
    Bull Exp Biol Med 132:666-9. 2001
    ..Possible mechanisms of the protective effect of these ligands are discussed...
  92. ncbi Resolution of anaphase bridges in cancer cells
    Diane R Hoffelder
    Department of Biological Sciences, University of Pittsburgh, 258 Crawford Hall, 15260, Pittsburgh, PA 15260, USA
    Chromosoma 112:389-97. 2004
    ..Thus, a major consequence of the presence of anaphase bridges is the regular sequestration of chromatin into genetically inert MN. This represents another source of ongoing genetic instability in cancer cells...
  93. ncbi [Clastogenicity of ethyl methanesulfonate and dimethyl terephthalate in the micronucleus test and ways for its modification]
    R I Goncharova
    Tsitol Genet 36:14-25. 2002
    ..This indicates that the antimutagen inhibits the clastogenesis by the induction or stimulation of endogenous components responsible for antioxidant defense and/or neutralization of electrophilic molecules...
  94. ncbi Evaluation of gamma-hydroxybutyric acid for genotoxicity in the mouse micronucleus assay
    S Balachandra Dass
    Neurochemistry Laboratory, Division of Neurotoxicology, National Center for Toxicological Research, Jefferson, Arkansas 72079, USA
    Ann N Y Acad Sci 1025:538-42. 2004
    ..However, because increases were small and because no consistent dose-dependent increase in induced micronuclear frequency could be demonstrated, our results do not conclusively show that GHB is an in vivo genotoxicant in mammals...
  95. ncbi Transient hypothermia induces micronuclei in mice
    S Asanami
    Naruto Research Institute, Otsuka Pharmaceutical Factory, Inc, Tokushima, Japan
    Mutat Res 413:7-14. 1998
    ..The results suggest that the transient hypothermia of less than 33 degrees C for 11 h induced micronuclei in bone marrow cells, and one possible mechanism was disturbance of the mitotic apparatus...
  96. pmc Sister chromatid exchanges and micronuclei in peripheral lymphocytes of shoe factory workers exposed to solvents
    Mariá Pitarque
    Grup de Mutagenesi, Departament de Genetica i de Microbiologia, Edifici Cn, Universitat Autonoma de Barcelona, Bellaterra, Spain
    Environ Health Perspect 110:399-404. 2002
    ..The exposures responsible for the MN induction could not be identified with certainty, but exposure to benzene in gasoline and methylenediphenyl diisocyanate may explain some of the findings...
  97. ncbi Micronucleus frequency in sheep lymphocytes after in vitro exposure to fungicide tolylfluanid
    Irena Sutiaková
    Department of Biology, University of Presov, Presov, Slovakia
    J Environ Sci Health B 45:606-11. 2010
    ..Tolylfluanid did not affect the nuclear division index at all treatment concentrations. Our in vitro results thus demonstrate that tolylfluanid had a significant genotoxic effect at only the highest concentration tested...
  98. ncbi DNA damage and micronucleus induction in human leukocytes after acute in vitro exposure to a 1.9 GHz continuous-wave radiofrequency field
    J P McNamee
    Consumer and Clinical Radiation Protection Bureau, Product Safety Programme, Health Canada, 775 Brookfield Road, Ottawa, Ontario, Canada
    Radiat Res 158:523-33. 2002
    ..These results do not support the hypothesis that acute, nonthermalizing 1.9 GHz CW RF-field exposure causes DNA damage in cultured human leukocytes...
  99. ncbi Induction of micronuclei by 153Sm-EDTMP in peripheral blood lymphocytes of patients with bone metastases
    Miriam F Suzuki
    Department of Radiation Metrology, NM, CNEN, Instituto de Pesquisas Energéticas e Nucleares, Cidade Universitaria, Sao Paulo, SP, Brazil
    Cell Mol Biol (Noisy-le-grand) 48:487-92. 2002
    ..The relatively low frequency of lymphocyte with micronuclei after the exposure to 153Sm-EDTMP supported the contention that radiation damage in lymphocytes of patients with painful bone metastases is minimal...
  100. ncbi Micronuclei induction by 13 week-inhalation of 1,1-dichloro-1-fluoroethane in Sprague-Dawley rats
    Seung Hee Maeng
    Center for Occupational Toxicology, Occupational Safety and Health Research Institute, Korea Occupational Safety and Health Agency, 305 380 Daejeon, South Korea
    Toxicol Lett 146:129-37. 2004
    ....
  101. ncbi The acute, genetic, developmental, and inhalation toxicology of 1,1,1,3,3-pentafluoropropane (HFC 245fa)
    G M Rusch
    AlliedSignal Inc, Morristown, New Jersey 07962 1139, USA
    Toxicol Sci 52:289-301. 1999
    ..There was an increased incidence of myocarditis in all animals exposed at 50,000 ppm and the majority exposed at 10,000 ppm. It was described as mild. Based on these findings, 2000 ppm appears to be a no observed adverse effect level...

Research Grants14

  1. Rapid Screen for Genotoxicants, Chemoprotectors, and Radioprotectors
    Stephen Dertinger; Fiscal Year: 2008
    ..In addition, this assay can be used to investigate agents designed to ameliorate the effects of radiation exposure, e.g. biological response modifiers. [unreadable] [unreadable] [unreadable] [unreadable]..
  2. High Throughput Radiation Biodosimetry
    Stephen Dertinger; Fiscal Year: 2007
    ..We propose to develop such a radiation biodosimetry assay based on the extremely high analysis rates that are possible with flow cytometry instrumentation. [unreadable] [unreadable] [unreadable]..
  3. Measuring Cytogenetic Damage in Human Blood
    Stephen Dertinger; Fiscal Year: 2003
    ..abstract_text> ..
  4. Versatile Mutation Assay Platform
    Stephen Dertinger; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  5. Automation of the vitro Micronucleus Assay
    Stephen Dertinger; Fiscal Year: 2004
    ..abstract_text> ..
  6. In vivo mutation assay based on pig-a locus
    Stephen Dertinger; Fiscal Year: 2004
    ....
  7. Molecular Biomarkers as Predictors of Hodgkin's Disease
    Randa El Zein; Fiscal Year: 2007
    ..The high risk population can be targeted for intensive preventive and early detection strategies. ..
  8. HIGH ENERGY IONS AND GENOMIC INSTABILITY
    Eric Hall; Fiscal Year: 2001
    ....
  9. Cytochrome C Oxidase I:A Biomarker for Colon Cancer Risk
    Claire Payne; Fiscal Year: 2006
    ..Various molecular and cellular techniques will be used in these studies. ..
  10. Radioprotective Potential of Ginseng
    Tung Kwang Lee; Fiscal Year: 2006
    ..Accomplishing these aims will provide an essential prerequisite to the development of NAGE as an effective radioprotector. ..
  11. Assessing toxicity with an ex vivo erythropoiesis system
    Dorothea Torous; Fiscal Year: 2003
    ..2. MEASURE the frequency of micronuclei in ex vivo derived reticulocytes. 3. DETERMINE the responsiveness of the system to known clastogens and a model aneugen. ..
  12. Flow Cytometric Method to Analyze Micronuclei
    Dorothea Torous; Fiscal Year: 2002
    ..Similar studies are planned for analysis kits to measure MN in mouse and rat bone marrow, rat peripheral blood and also human peripheral blood. Enormous commercial opportunity exists from the sale of these kits. ..
  13. MECHANISM OF ACTION OF CRYTOPHYCINS
    Susan Mooberry; Fiscal Year: 2002
    ..The differences in the biological responses of the congeners will determine the relationships between biological events and the ultimate ability to initiate apoptosis. ..
  14. Preventive of Bile Acid-Induced Colonic Oxidative DNA Damage
    Claire Margaret Payne; Fiscal Year: 2010
    ..129 mice) developed in our laboratory;2) NOS-/- k.o./DOC mouse model;3) arginine-enhanced colon tumor ApcMin/+ mouse model developed in our laboratory;4) the AOM mouse model of colon carcinogenesis using A/J mice. ..