colonic polyps

Summary

Summary: Discrete tissue masses that protrude into the lumen of the COLON. These POLYPS are connected to the wall of the colon either by a stalk, pedunculus, or by a broad base.

Top Publications

  1. ncbi CT colonography versus colonoscopy for the detection of advanced neoplasia
    David H Kim
    Department of Radiology, University of Wisconsin Medical School, Madison 53792 3252, USA
    N Engl J Med 357:1403-12. 2007
  2. ncbi Is metabolic syndrome a risk factor for colorectal adenoma?
    Jeong Hwan Kim
    Department of Internal Medicine, Konkuk University Hospital, Konkuk University School of Medicine, Seoul 135 710, Korea
    Cancer Epidemiol Biomarkers Prev 16:1543-6. 2007
  3. ncbi Comparison of microsatellite instability, CpG island methylation phenotype, BRAF and KRAS status in serrated polyps and traditional adenomas indicates separate pathways to distinct colorectal carcinoma end points
    Michael J O'Brien
    Department of Pathology, Boston University Medical Center, Boston, MA 02118, USA
    Am J Surg Pathol 30:1491-501. 2006
  4. ncbi Risk factors for advanced colonic neoplasia and hyperplastic polyps in asymptomatic individuals
    David A Lieberman
    Division of Gastroenterology, Department of Veterans Affairs Medical Center, Portland, Ore 97207, USA
    JAMA 290:2959-67. 2003
  5. ncbi Hyperplastic polyposis coli syndrome and colorectal carcinoma
    C A Rubio
    Gastrointestinal and Liver Pathology Research Laboratory, Department of Pathology, Karolinska Institute and University Hospital, 17176 Stockholm, Sweden
    Endoscopy 38:266-70. 2006
  6. ncbi Screening and surveillance for the early detection of colorectal cancer and adenomatous polyps, 2008: a joint guideline from the American Cancer Society, the US Multi-Society Task Force on Colorectal Cancer, and the American College of Radiology
    Bernard Levin
    The University of Texas MD Anderson Cancer Center, Houston, TX, USA
    CA Cancer J Clin 58:130-60. 2008
  7. pmc BRAF mutation is associated with DNA methylation in serrated polyps and cancers of the colorectum
    T Kambara
    Conjoint Gastroenterology Laboratory, Royal Brisbane and Women s Hospital Research Foundation and Queensland Institute of Medical Research, Brisbane 4029, Australia
    Gut 53:1137-44. 2004
  8. pmc Efficacy in standard clinical practice of colonoscopic polypectomy in reducing colorectal cancer incidence
    F Citarda
    Regina Elena Cancer Institute, Rome, Italy
    Gut 48:812-5. 2001
  9. ncbi Update on the serrated pathway to colorectal carcinoma
    Dale C Snover
    Department of Pathology, Fairview Southdale Hospital, Hibbing, MN 55746, USA
    Hum Pathol 42:1-10. 2011
  10. ncbi Serrated polyps and colorectal cancer: new pathway to malignancy
    Amy E Noffsinger
    Department of Pathology, The University of Chicago, Chicago, IL 60637, USA
    Annu Rev Pathol 4:343-64. 2009

Research Grants

Detail Information

Publications359 found, 100 shown here

  1. ncbi CT colonography versus colonoscopy for the detection of advanced neoplasia
    David H Kim
    Department of Radiology, University of Wisconsin Medical School, Madison 53792 3252, USA
    N Engl J Med 357:1403-12. 2007
    ..Advanced neoplasia represents the primary target for colorectal-cancer screening and prevention. We compared the diagnostic yield from parallel computed tomographic colonography (CTC) and optical colonoscopy (OC) screening programs...
  2. ncbi Is metabolic syndrome a risk factor for colorectal adenoma?
    Jeong Hwan Kim
    Department of Internal Medicine, Konkuk University Hospital, Konkuk University School of Medicine, Seoul 135 710, Korea
    Cancer Epidemiol Biomarkers Prev 16:1543-6. 2007
    ..However, there is a lack of information about the relationship between metabolic syndrome and colorectal adenoma. Therefore, we investigated whether metabolic syndrome is a risk factor for colorectal adenoma...
  3. ncbi Comparison of microsatellite instability, CpG island methylation phenotype, BRAF and KRAS status in serrated polyps and traditional adenomas indicates separate pathways to distinct colorectal carcinoma end points
    Michael J O'Brien
    Department of Pathology, Boston University Medical Center, Boston, MA 02118, USA
    Am J Surg Pathol 30:1491-501. 2006
    ....
  4. ncbi Risk factors for advanced colonic neoplasia and hyperplastic polyps in asymptomatic individuals
    David A Lieberman
    Division of Gastroenterology, Department of Veterans Affairs Medical Center, Portland, Ore 97207, USA
    JAMA 290:2959-67. 2003
    ..Few studies have evaluated risk factors for advanced colorectal neoplasia in asymptomatic individuals, compared risk factors between persons with and without polyps, or included most purported risk factors in a multivariate analysis...
  5. ncbi Hyperplastic polyposis coli syndrome and colorectal carcinoma
    C A Rubio
    Gastrointestinal and Liver Pathology Research Laboratory, Department of Pathology, Karolinska Institute and University Hospital, 17176 Stockholm, Sweden
    Endoscopy 38:266-70. 2006
    ..Patients with hyperplastic polyposis coli syndrome (HPCS) have a propensity to develop colorectal carcinoma (CRC)...
  6. ncbi Screening and surveillance for the early detection of colorectal cancer and adenomatous polyps, 2008: a joint guideline from the American Cancer Society, the US Multi-Society Task Force on Colorectal Cancer, and the American College of Radiology
    Bernard Levin
    The University of Texas MD Anderson Cancer Center, Houston, TX, USA
    CA Cancer J Clin 58:130-60. 2008
    ..It is the strong opinion of these 3 organizations that colon cancer prevention should be the primary goal of screening...
  7. pmc BRAF mutation is associated with DNA methylation in serrated polyps and cancers of the colorectum
    T Kambara
    Conjoint Gastroenterology Laboratory, Royal Brisbane and Women s Hospital Research Foundation and Queensland Institute of Medical Research, Brisbane 4029, Australia
    Gut 53:1137-44. 2004
    ..However, the distribution of BRAF mutations in MSI-H cancers remains to be clarified with respect to precursor lesions and the CpG island methylator phenotype (CIMP)...
  8. pmc Efficacy in standard clinical practice of colonoscopic polypectomy in reducing colorectal cancer incidence
    F Citarda
    Regina Elena Cancer Institute, Rome, Italy
    Gut 48:812-5. 2001
    ....
  9. ncbi Update on the serrated pathway to colorectal carcinoma
    Dale C Snover
    Department of Pathology, Fairview Southdale Hospital, Hibbing, MN 55746, USA
    Hum Pathol 42:1-10. 2011
    ..This article reviews the various pathways to colorectal carcinoma with emphasis on the serrated pathway and evaluates the implications of this pathway for colorectal carcinomas screening programs...
  10. ncbi Serrated polyps and colorectal cancer: new pathway to malignancy
    Amy E Noffsinger
    Department of Pathology, The University of Chicago, Chicago, IL 60637, USA
    Annu Rev Pathol 4:343-64. 2009
    ..The morphologic features of serrated colorectal lesions, the molecular alterations that characterize them, and their role in colorectal cancer development are discussed herein...
  11. ncbi Differentiating adenomas from hyperplastic colorectal polyps: narrow-band imaging can be learned in 20 minutes
    Meghana Raghavendra
    Division of Gastroenterology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA
    Gastrointest Endosc 72:572-6. 2010
    ..Colonoscopy with narrow-band imaging can allow real-time determination of polyp histology...
  12. ncbi Recognition of surface mucosal and vascular patterns of colon polyps by using narrow-band imaging: interobserver and intraobserver agreement and prediction of polyp histology
    Amit Rastogi
    Division of Gastroenterology and Hepatology, Veterans Affairs Medical Center, Kansas City, Missouri 64128, USA
    Gastrointest Endosc 69:716-22. 2009
    ..Earlier we described, in a pilot study, patterns seen on the polyp surface with NBI that can help differentiate between adenomas and hyperplastic polyps with a high degree of accuracy...
  13. ncbi Quality in the technical performance of colonoscopy and the continuous quality improvement process for colonoscopy: recommendations of the U.S. Multi-Society Task Force on Colorectal Cancer
    Douglas K Rex
    Department of Medicine Gastroenterology, Indiana University Medical Center, Indianapolis, USA
    Am J Gastroenterol 97:1296-308. 2002
  14. ncbi Morphologic reappraisal of serrated colorectal polyps
    Emina Torlakovic
    Department of Pathology, The Norwegian Radium Hospital, University of Oslo, Norway
    Am J Surg Pathol 27:65-81. 2003
    ....
  15. ncbi BRAF and KRAS Mutations in hyperplastic polyps and serrated adenomas of the colorectum: relationship to histology and CpG island methylation status
    Shi Yang
    Department of Pathology, Boston Medical Center, Boston, MA 02118, USA
    Am J Surg Pathol 28:1452-9. 2004
    ..In contrast, the association of higher levels of CpG island methylation with more advanced histologic changes suggests that CpG island methylation plays a role in serrated polyp progression toward colorectal carcinoma...
  16. ncbi Cap-fitted colonoscopy: a randomized, tandem colonoscopy study of adenoma miss rates
    David G Hewett
    Division of Gastroenterology Hepatology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA
    Gastrointest Endosc 72:775-81. 2010
    ..Failures of adenoma detection diminish the effectiveness of colonoscopy...
  17. ncbi Narrow-band imaging without high magnification to differentiate polyps during real-time colonoscopy: improvement with experience
    Jason N Rogart
    Section of Digestive Diseases, Yale University School of Medicine, New Haven, Connecticut 06520 8019, USA
    Gastrointest Endosc 68:1136-45. 2008
    ..There is no widely adopted, easily applied method for distinguishing between adenomatous and nonadenomatous polyps during real-time colonoscopy...
  18. ncbi Computer-based classification of small colorectal polyps by using narrow-band imaging with optical magnification
    Sebastian Gross
    Medical Department III Gastroenterology, Hepatology, and Metabolic Diseases, University Hospital RWTH Aachen, Aachen, Germany
    Gastrointest Endosc 74:1354-9. 2011
    ..Recent studies have shown that narrow-band imaging (NBI) is a powerful diagnostic tool for the differentiation between neoplastic and non-neoplastic colorectal polyps...
  19. pmc Phenotype and polyp landscape in serrated polyposis syndrome: a series of 100 patients from genetics clinics
    Christophe Rosty
    Pathology Queensland, Royal Brisbane and Women s Hospital, Herston, QLD 4006, Australia
    Am J Surg Pathol 36:876-82. 2012
    ..003). Patients with SPS referred to genetics clinics had a pancolonic disease with a high polyp burden and a high rate of BRAF mutation. The occurrence of CRC was associated with the presence of conventional adenoma...
  20. ncbi Surface normal overlap: a computer-aided detection algorithm with application to colonic polyps and lung nodules in helical CT
    David S Paik
    Department of Radiology, Stanford University, Stanford, CA 94305 5450, USA
    IEEE Trans Med Imaging 23:661-75. 2004
    ..It is able to achieve 100% sensitivity for colonic polyps 10 mm and larger at 7...
  21. ncbi Diagnostic accuracy of narrow-band imaging for the differentiation of neoplastic from non-neoplastic colorectal polyps: a meta-analysis
    L Wu
    Department of Colorectal and Anal Surgery, First Affiliated Hospital, Guangxi Medical University, Nanning, Guangxi, China
    Colorectal Dis 15:3-11. 2013
    ..However, the real accuracy for the differentiation of neoplastic from non-neoplastic polyps by NBI for the colorectum is still unknown...
  22. ncbi A quantitative assessment of the risks and cost savings of forgoing histologic examination of diminutive polyps
    W R Kessler
    Division of Gastroenterology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Endoscopy 43:683-91. 2011
    ..This study aimed to quantify the expected costs and outcomes of removing diminutive polyps without subsequent pathologic assessment...
  23. pmc Colorectal endoscopy, advanced adenomas, and sessile serrated polyps: implications for proximal colon cancer
    Andrea N Burnett-Hartman
    Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
    Am J Gastroenterol 107:1213-9. 2012
    ....
  24. ncbi Development and validation of a training module on the use of narrow-band imaging in differentiation of small adenomas from hyperplastic colorectal polyps
    Ana Ignjatovic
    Wolfson Unit for Endoscopy, St Mark s Hospital, Harrow, Middlesex, United Kingdom
    Gastrointest Endosc 73:128-33. 2011
    ..Experts are accurate in differentiating small adenomas from hyperplastic polyps at colonoscopy by using narrow-band imaging (NBI)...
  25. ncbi Meshed capillary vessels found on narrow-band imaging without optical magnification effectively identifies colorectal neoplasia: a North American validation of the Japanese experience
    Zachary H Henry
    Division of Gastroenterology and Hepatology, Department of Medicine, University of Virginia, Charlottesville, Virginia, USA
    Gastrointest Endosc 72:118-26. 2010
    ..However, the efficacy of NBI to identify an MC pattern without optical magnification has not been determined...
  26. ncbi Accuracy of in vivo optical diagnosis of colon polyp histology by narrow-band imaging in predicting colonoscopy surveillance intervals
    Neil Gupta
    Division of Gastroenterology, Kansas City Veterans Affairs Medical Center, Kansas City, Missouri 64128, USA
    Gastrointest Endosc 75:494-502. 2012
    ..Narrow-band imaging (NBI) has been shown to predict polyp histology with moderate to high accuracy in several studies...
  27. ncbi Value of magnifying endoscopy in classifying colorectal polyps based on vascular pattern
    J J W Tischendorf
    Department of Gastroenterology, Hepatology and Metabolic Diseases, University Hospital Aachen, D 52074 Aachen, Germany
    Endoscopy 42:22-7. 2010
    ..The aim of this study was to evaluate the diagnostic accuracy of NBI endoscopy with and without high magnification for the differentiation of neoplastic from non-neoplastic colorectal polyps...
  28. ncbi Leaving distal colorectal hyperplastic polyps in place can be achieved with high accuracy by using narrow-band imaging: an observational study
    David G Hewett
    Indiana University School of Medicine, Indianapolis, Indiana, USA
    Gastrointest Endosc 76:374-80. 2012
    ..Accurate colonoscopic assessment of colorectal polyp histology could avoid resection of distal nonadenomatous polyps and reduce costs and risk...
  29. ncbi Narrow-band imaging versus I-Scan for the real-time histological prediction of diminutive colonic polyps: a prospective comparative study by using the simple unified endoscopic classification
    Chang Kyun Lee
    Division of Gastroenterology, Department of Internal Medicine, Kyung Hee University School of Medicine, Dongdaemun Gu, Seoul, Korea
    Gastrointest Endosc 74:603-9. 2011
    ..Digital chromoendoscopy (DCE) has the potential for the in vivo optical diagnosis of colon polyps. However, no comparison of different DCE technologies currently exists...
  30. ncbi Five-year risk for advanced colorectal neoplasia after initial colonoscopy according to the baseline risk stratification: a prospective study in 2452 asymptomatic Koreans
    Su Jin Chung
    Department of Internal Medicine, Seoul National University College of Medicine, Seoul, South Korea
    Gut 60:1537-43. 2011
    ..The aim of this study was to assess the 5-year incidence of advanced neoplasia recurrence based on the risk stratification scheme of the guidelines and to identify its risk factors...
  31. ncbi Comparative study of conventional colonoscopy, magnifying chromoendoscopy, and magnifying narrow-band imaging systems in the differential diagnosis of small colonic polyps between trainee and experienced endoscopist
    Chun Chao Chang
    Division of Gastroenterology, Department of Internal Medicine, Taipei Medical University Hospital and Digestive Disease Research Center, Taipei, Taiwan
    Int J Colorectal Dis 24:1413-9. 2009
    ..We compared the ability of a trainee and an experienced endoscopist in distinguishing between neoplastic polyps and nonneoplastic polyps by conventional white-light, magnifying narrow-band imaging (NBI), and magnifying chromoendoscopy...
  32. pmc Serrated lesions of the colorectum: review and recommendations from an expert panel
    Douglas K Rex
    Indiana University, Indianapolis, Indiana, USA
    Am J Gastroenterol 107:1315-29; quiz 1314, 1330. 2012
    ..Recommendations are made for post-polypectomy surveillance of serrated lesions and for surveillance of serrated polyposis patients and their relatives...
  33. ncbi A comparison of magnifying and nonmagnifying colonoscopy for diagnosis of colorectal polyps: A prospective study
    Kazuo Konishi
    Second Department of Internal Medicine, Division of Hospital Pathology, Showa University School of Medicine, Tokyo, Japan
    Gastrointest Endosc 57:48-53. 2003
    ..This study prospectively compared the ability to distinguish between neoplastic and non-neoplastic lesions by magnifying and nonmagnifying colonoscopy...
  34. pmc Concordant CpG island methylation in hyperplastic polyposis
    Annie On On Chan
    Department of Pathology, University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030 4095, USA
    Am J Pathol 160:529-36. 2002
    ..The hypermethylator phenotype is related to patient-specific factors, such as carcinogenic exposure or genetic predisposition...
  35. pmc Frequent CpG island methylation in serrated adenomas of the colorectum
    Seun Ja Park
    Department of Pathology, University of Texas, M D Anderson Cancer Center, Houston, Texas 77030 4095, USA
    Am J Pathol 162:815-22. 2003
    ..Our results indicate that CpG island methylation is common in sporadic serrated adenomas and may play an important role in their pathogenesis...
  36. ncbi High accuracy of narrow band imaging without magnification for the real-time characterization of polyp histology and its comparison with high-definition white light colonoscopy: a prospective study
    Amit Rastogi
    Division of Gastroenterology and Hepatology, University of Kansas School of Medicine, Veterans Affairs Medical Center, Kansas City, Missouri 64128, USA
    Am J Gastroenterol 104:2422-30. 2009
    ..hyperplastic) by evaluating the surface mucosal and vascular patterns...
  37. pmc A prospective comparative study of narrow-band imaging, chromoendoscopy, and conventional colonoscopy in the diagnosis of colorectal neoplasia
    Han Mo Chiu
    Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan
    Gut 56:373-9. 2007
    ..Application of narrow-band imaging (NBI) in colonoscopy visualises mucosal vascular networks in neoplastic lesions and may improve diagnostic accuracy...
  38. pmc Clinicopathological features of colon polyps from African-Americans
    Mehdi Nouraie
    Department of Medicine and Cancer Center, Howard University College of Medicine, 2041 Georgia Avenue, NW, Washington, DC 20060, USA
    Dig Dis Sci 55:1442-9. 2010
    ..It is shown that 30% of the US adult population has adenomas. The potential risk of malignant transformation in adenomas differs by specific pathologic and clinical characteristics that we aimed to study in AAs...
  39. ncbi Comparison of probe-based confocal laser endomicroscopy with virtual chromoendoscopy for classification of colon polyps
    Anna M Buchner
    Department of Gastroenterology and Hepatology, Mayo Clinic, Jacksonville, Florida, USA
    Gastroenterology 138:834-42. 2010
    ..A secondary aim was to compare sensitivity and specificity of pCLE to virtual chromoendoscopy using a modified gold standard that assumed that all polyps >/=10 mm had malignant potential and were considered neoplastic or high risk...
  40. ncbi Risk factors for severe delayed postpolypectomy bleeding
    M S Sawhney
    Section of Gastroenterology Minneapolis Veterans Administration Medical Center, Minneapolis, USA
    Endoscopy 40:115-9. 2008
    ..Postpolypectomy bleeding is a rare but serious adverse event. The aim of this study was to identify factors associated with the risk of severe delayed postpolypectomy bleeding...
  41. ncbi Diagnosis of colorectal lesions with the magnifying narrow-band imaging system
    Yoshiki Wada
    Digestive Disease Center, Showa University Northern Yokohama Hospital, Yokohama, Japan
    Gastrointest Endosc 70:522-31. 2009
    ..Narrow-band imaging (NBI) emphasizes the surface microvasculature of the GI tract and may help in detecting small neoplasms...
  42. ncbi Narrow band imaging with magnification for the characterization of small and diminutive colonic polyps: pit pattern and vascular pattern intensity
    J E East
    Wolfson Unit for Endoscopy, St Mark s Hospital, Imperial College London, London, UK
    Endoscopy 40:811-7. 2008
    Narrow band imaging (NBI) can accurately characterize colonic polyps using microvascular appearances...
  43. pmc Colorectal cancer: CT colonography and colonoscopy for detection--systematic review and meta-analysis
    Perry J Pickhardt
    Department of Radiology, University of Wisconsin School of Medicine and Public Health, E3 311 Clinical Science Center, 600 Highland Ave, Madison, WI 53792 3252, USA
    Radiology 259:393-405. 2011
    ..To perform a systematic review and meta-analysis of published studies assessing the sensitivity of both computed tomographic (CT) colonography and optical colonoscopy (OC) for colorectal cancer detection...
  44. ncbi Comparative study of conventional colonoscopy and pan-colonic narrow-band imaging system in the detection of neoplastic colonic polyps: a randomized, controlled trial
    Takuya Inoue
    Second Department of Internal Medicine, Osaka Medical College, 2 7 Daigakumachi, Takatsuki, 569 8686, Japan
    J Gastroenterol 43:45-50. 2008
    ..We conducted a randomized, controlled trial to determine the efficacy of the pancolonic NBI system in adenoma detection...
  45. ncbi Flat and depressed colonic neoplasms: a prospective study of 1000 colonoscopies in the UK
    B J Rembacken
    Centre for Digestive Diseases, The General Infirmary, Leeds
    Lancet 355:1211-4. 2000
    ..Flat and depressed colorectal tumours were originally thought to be unique to the Japanese population. Recently there have been reports of flat and depressed lesions in western countries but they have been thought to be uncommon...
  46. ncbi Comparison of CT colonography, colonoscopy, sigmoidoscopy and faecal occult blood tests for the detection of advanced adenoma in an average risk population
    A Graser
    Department of Clinical Radiology, University of Munich, Klinikum Grosshadern, Munich, Germany
    Gut 58:241-8. 2009
    ....
  47. ncbi Meshed capillary vessels by use of narrow-band imaging for differential diagnosis of small colorectal polyps
    Yasushi Sano
    Gastrointestinal Center, Sano Hospital, Kobe, Hyogo, Japan
    Gastrointest Endosc 69:278-83. 2009
    ..Although microvascular vessels on the surface of colorectal polyps are observed by narrow-band imaging (NBI) with magnification, its clinical usefulness is still uncertain...
  48. ncbi Comparative study of conventional colonoscopy, chromoendoscopy, and narrow-band imaging systems in differential diagnosis of neoplastic and nonneoplastic colonic polyps
    Ming Yao Su
    Department of Gastroenterology and Hepatology, Lin Kou Medical Center, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Taoyuan, Taiwan
    Am J Gastroenterol 101:2711-6. 2006
    To identify the feasibility of the narrow-band imaging (NBI) method compared with that of conventional colonoscopy and chromoendoscopy for distinguishing neoplastic and nonneoplastic colonic polyps.
  49. ncbi Serrated and non-serrated polyps of the colorectum: their prevalence in an unselected case series and correlation of BRAF mutation analysis with the diagnosis of sessile serrated adenoma
    N J Carr
    Graduate School of Medicine, University of Wollongong, New South Wales, Australia
    J Clin Pathol 62:516-8. 2009
    ..To determine the prevalence of colorectal polyps of different types in an unselected population, and to correlate the morphological diagnoses with BRAF mutation analysis...
  50. pmc Beta-catenin nuclear labeling is a common feature of sessile serrated adenomas and correlates with early neoplastic progression after BRAF activation
    Shinichi Yachida
    Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD 21231, USA
    Am J Surg Pathol 33:1823-32. 2009
    ....
  51. ncbi Computer-aided classification of colorectal polyps based on vascular patterns: a pilot study
    J J W Tischendorf
    Medical Department III Gastroenterology, Hepatology and Metabolic Diseases, Aachen University Hospital, RWTH Aachen University, 52074 Aachen, Germany
    Endoscopy 42:203-7. 2010
    ..The aim of the present study was to develop and evaluate a computer-based method for automated classification of colorectal polyps on the basis of vascularization features...
  52. pmc A pooled analysis of advanced colorectal neoplasia diagnoses after colonoscopic polypectomy
    Maria Elena Martinez
    Arizona Cancer Center, University of Arizona, Tucson, Arizona, USA
    Gastroenterology 136:832-41. 2009
    ..Limited data exist regarding the actual risk of developing advanced adenomas and cancer after polypectomy or the factors that determine risk...
  53. ncbi Risk of colonoscopic polypectomy bleeding with anticoagulants and antiplatelet agents: analysis of 1657 cases
    Aric J Hui
    Department of Medicine and Therapeutics, Prince of Wales Hospital, Shatin, Hong Kong, China
    Gastrointest Endosc 59:44-8. 2004
    ..Anticoagulants and antiplatelet agents commonly are used to treat patients with cardiovascular and cerebrovascular diseases. Data on the safety of the use of these drugs before colonoscopic polypectomy are scanty...
  54. ncbi A resect and discard strategy would improve cost-effectiveness of colorectal cancer screening
    Cesare Hassan
    Digestive Endoscopy Unit, Nuovo Regina Margherita Hospital, Rome, Italy
    Clin Gastroenterol Hepatol 8:865-9, 869.e1-3. 2010
    ..We modeled the cost-effectiveness of this policy...
  55. ncbi Hyperplastic-like polyps as precursors of microsatellite-unstable colorectal cancer
    Jeremy R Jass
    Am J Clin Pathol 119:773-5. 2003
  56. ncbi Are physicians doing too much colonoscopy? A national survey of colorectal surveillance after polypectomy
    Pauline A Mysliwiec
    National Cancer Institute, Bethesda, Maryland 20892 7344, USA
    Ann Intern Med 141:264-71. 2004
    ..Guidelines recommend surveillance after polypectomy at 3 to 5 years for a small adenoma, and follow-up is not advised for hyperplastic polyps. The intensity of physicians' surveillance is largely unstudied...
  57. ncbi Optical diagnosis of small colorectal polyps at routine colonoscopy (Detect InSpect ChAracterise Resect and Discard; DISCARD trial): a prospective cohort study
    Ana Ignjatovic
    Wolfson Unit for Endoscopy, St Mark s Hospital, Imperial College London, HA1 3UJ, UK
    Lancet Oncol 10:1171-8. 2009
    ..The aim of this study was to assess whether optical diagnosis of small polyps is feasible and safe in routine clinical practice...
  58. ncbi Computed tomography colonography: feasibility of computer-aided polyp detection in a "first reader" paradigm
    Aravind Mani
    Department of Radiology, Stanford University Medical Center, and Stanford Medical School, CA 94305, USA
    J Comput Assist Tomogr 28:318-26. 2004
    ..To determine the feasibility of a computer-aided detection (CAD) algorithm as the "first reader" in computed tomography colonography (CTC)...
  59. ncbi Meta-analysis of narrow-band imaging versus conventional colonoscopy for adenoma detection
    Lotte Dinesen
    AW Morrow Gastroenterology and Liver Centre, Royal Prince Alfred Hospital, Sydney, New South Wales, Australia
    Gastrointest Endosc 75:604-11. 2012
    ..Narrow-band imaging (NBI) has been extensively evaluated in prospective, randomized, controlled studies for polyp detection. Sample-size calculations show us that these studies may be underpowered, and hence a meta-analysis is required...
  60. ncbi Risk assessment for delayed hemorrhagic complication of colonic polypectomy: polyp-related factors and patient-related factors
    Hirotsugu Watabe
    Department of Gastroenterology, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, Japan 113 8655
    Gastrointest Endosc 64:73-8. 2006
    ..Hemorrhage is among the most serious complications of colorectal polypectomy and may occur after a longer postprocedure interval...
  61. ncbi Externalization of saw-tooth architecture in small serrated polyps implies the presence of methylation of IGFBP7
    Eisuke Kaji
    Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2 5 1 Shikata cho, Kita ku, Okayama 700 8558, Japan
    Dig Dis Sci 57:1261-70. 2012
    ..However, the biological and/or morphological changes which occur during the course of serrated polyp to cancer remain to be elucidated...
  62. ncbi Omega-3 polyunsaturated fatty acids
    Mark A Hull
    Section of Molecular Gastroenterology, Leeds Institute of Molecular Medicine, St James s University Hospital, Leeds, United Kingdom
    Best Pract Res Clin Gastroenterol 25:547-54. 2011
    ..A randomized polyp prevention trial of EPA is underway in order to test chemopreventative efficacy against 'sporadic' colorectal neoplasia...
  63. ncbi Colorectal screening after polypectomy: a national survey study of primary care physicians
    Vikram Boolchand
    University Hospitals of Cleveland, Case Western Reserve University, Cleveland, Ohio, USA
    Ann Intern Med 145:654-9. 2006
    ..Recommendations by primary care physicians for colorectal screening after polypectomy will influence rates of colonoscopy in open-access systems that do not require consultation by a gastroenterologist before colonoscopy...
  64. ncbi From colonic polyps to colon cancer: pathophysiology, clinical presentation, screening and colonoscopic therapy
    M S Cappell
    Division of Gastroenterology, William Beaumont Hospital, Royal Oak, MI 48073, USA
    Minerva Gastroenterol Dietol 53:351-73. 2007
    ..Yet, colon cancer is largely preventable through intensive, mass screening programs to remove premalignant colonic polyps. The persistently high incidence and mortality is largely due to ineffective implementation of established ..
  65. ncbi Pathological reassessment of hyperplastic colon polyps in a city-wide pathology practice: implications for polyp surveillance recommendations
    Harminder Singh
    Internal Medicine, University of Manitoba, Winnipeg, Manitoba, Canada
    Gastrointest Endosc 76:1003-8. 2012
    ..On the other hand, recent guidelines such as those from the European Union consider HPs of limited clinical significance...
  66. ncbi Miss rate of right-sided colon examination during colonoscopy defined by retroflexion: an observational study
    David G Hewett
    Division of Gastroenterology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA
    Gastrointest Endosc 74:246-52. 2011
    ..Colonoscopy is less effective in the proximal compared with the distal colon...
  67. pmc Accuracy of administrative claims data for polypectomy
    Jonathan M Wyse
    Division of Gastroenterology, Department of Medicine, Jewish General Hospital, McGill University, Montreal, Canada
    CMAJ 183:E743-7. 2011
    ..We determined the level of agreement between physician claims for polypectomy and documentation of the procedure in endoscopy reports...
  68. ncbi Sessile serrated adenoma with early neoplastic progression: a clinicopathologic and molecular study
    Kohei Fujita
    Department of Anatomic Pathology, Kyushu University, Fukuoka, Japan
    Am J Surg Pathol 35:295-304. 2011
    ..In addition, our histologic observations suggest a possible close association between SSAN and mucinous adenocarcinoma...
  69. pmc Body size, IGF and growth hormone polymorphisms, and colorectal adenomas and hyperplastic polyps
    Karen J Wernli
    Program in Cancer Prevention, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Growth Horm IGF Res 20:305-9. 2010
    ....
  70. pmc Prevalence of colon polyps detected by colonoscopy screening in asymptomatic black and white patients
    David A Lieberman
    Division of Gastroenterology, Portland VA Medical Center, 1037SW Veterans Hospital Rd, P3 GI, Portland, OR 97239, USA
    JAMA 300:1417-22. 2008
    ..Colorectal cancer screening might be less effective in black individuals, if there are racial differences in the age-adjusted prevalence and location of cancer precursor lesions...
  71. ncbi Postpolypectomy lower gastrointestinal bleeding: potential role of aspirin
    Mahmoud Yousfi
    Department of Internal Medicine, Division of Gastroenterology and Hepatology, Mayo Clinic Rochester, 200 First Street SW, Rochester, MN 55905, USA
    Am J Gastroenterol 99:1785-9. 2004
    ....
  72. ncbi Failure to recognize serrated polyposis syndrome in a cohort with large sessile colorectal polyps
    Krishna C Vemulapalli
    Department of Medicine, Division of Gastroenterology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Gastrointest Endosc 75:1206-10. 2012
    ..Serrated polyposis syndrome (SPS) is a rare condition of multiple serrated colorectal polyps and cancers. Colorectal cancer risk is increased in SPS...
  73. ncbi Stool screening for colorectal cancer: evolution from occult blood to molecular markers
    David A Ahlquist
    Division of Gastroenterology and Hepatology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Clin Chim Acta 315:157-68. 2002
    ..Participation rates for colorectal cancer screening remain low due, in part, to perceived discomfort, potential harm, and high costs with available tools...
  74. ncbi Management of small and diminutive colorectal polyps: a review of the literature
    S G Coe
    Division of Gastroenterology, Mayo Clinic Florida, Jacksonville, FL 32224, USA
    Minerva Gastroenterol Dietol 57:167-76. 2011
    ....
  75. ncbi Feasibility and accuracy of confocal endomicroscopy in comparison with narrow-band imaging and chromoendoscopy for the differentiation of colorectal lesions
    T Kuiper
    Department of Gastroenterology and Hepatology, Academic Medical Centre Amsterdam, Amsterdam, The Netherlands
    Am J Gastroenterol 107:543-50. 2012
    ..Furthermore, the accuracy of pCLE for the differentiation of colorectal lesions was assessed and compared with narrow-band imaging (NBI) and chromoendoscopy (CE)...
  76. ncbi High prevalence of sessile serrated adenomas with BRAF mutations: a prospective study of patients undergoing colonoscopy
    Kevin J Spring
    Conjoint Gastroenterology Laboratory, Queensland Institute of Medical Research, Herston, Brisbane, Australia
    Gastroenterology 131:1400-7. 2006
    ..This prospective study examined the prevalence of sessile serrated adenomas and determined the incidence of BRAF and K-ras mutations in different types of polyps...
  77. ncbi A prospective randomised study on narrow-band imaging versus conventional colonoscopy for adenoma detection: does narrow-band imaging induce a learning effect?
    A Adler
    Central Interdisciplinary Endoscopy Unit, Department of Gastroenterology, Virchow Clinic Campus, Charité Medical University of Berlin, Augustenburger Platz 1, 13353 Berlin, Germany
    Gut 57:59-64. 2008
    ..Detection rates are expected to improve with optimised visualisation methods. This prospective randomised study evaluated narrow-band imaging (NBI), a new technique that may enhance image contrast in colon adenoma detection...
  78. ncbi An intelligent system for automatic detection of gastrointestinal adenomas in video endoscopy
    Dimitris K Iakovidis
    Department of Informatics and Telecommunications, University of Athens, Panepistimiopolis, Illisia, 15784 Athens, Greece
    Comput Biol Med 36:1084-103. 2006
    ..It combines intelligent processing techniques of SVMs and color-texture analysis methodologies into a sound pattern recognition framework. Concerning the system's accuracy this was measured using ROC analysis and found to exceed 94%...
  79. ncbi Hyperplastic-like colon polyps that preceded microsatellite-unstable adenocarcinomas
    Neal S Goldstein
    Dept of Anatomic Pathology, William Beaumont Hospital, 3601 W Thirteen Mile Rd, Royal Oak, MI 48073, USA
    Am J Clin Pathol 119:778-96. 2003
    ..The morphologic features described herein provide initial guidelines to identify this potentially important subset of premalignant serrated-like polyps...
  80. ncbi Combining autofluorescence imaging and narrow-band imaging for the differentiation of adenomas from non-neoplastic colonic polyps among experienced and non-experienced endoscopists
    Frank J C van den Broek
    Department of Gastroenterology and Hepatology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Am J Gastroenterol 104:1498-507. 2009
    ..In this study, we aimed to assess the interobserver variability and accuracy of HR-WLE, NBI, and AFI for polyp differentiation and to evaluate the combined use of AFI and NBI...
  81. ncbi Recurrence and surveillance of colorectal adenoma after polypectomy in a southern Chinese population
    Yinglong Huang
    Department of Gastroenterology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, People s Republic of China
    J Gastroenterol 45:838-45. 2010
    ..The aim of this study was to estimate the actual recurrence rate of adenoma and its association with the length of the surveillance interval after polypectomy in a southern Chinese population...
  82. ncbi The presence of large serrated polyps increases risk for colorectal cancer
    Sakiko Hiraoka
    Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan
    Gastroenterology 139:1503-10, 1510.e1-3. 2010
    ..We used a colonoscopy database to determine the association between the presence of serrated colorectal polyps and colorectal neoplasia...
  83. ncbi A randomized trial of aspirin to prevent colorectal adenomas in patients with previous colorectal cancer
    Robert S Sandler
    Department of Medicine, University of North Carolina, Chapel Hill 27599 7555, USA
    N Engl J Med 348:883-90. 2003
    ..Experimental studies in animals and observational studies in humans suggest that regular aspirin use may decrease the risk of colorectal adenomas, the precursors to most colorectal cancers...
  84. pmc Physical activity and risk of colon adenoma: a meta-analysis
    K Y Wolin
    Division of Public Health Sciences, Department of Surgery, Washington University School of Medicine in St Louis and Alvin J Siteman Cancer Center, 660 S Euclid Avenue, Box 8100, St Louis, MO 63110, USA
    Br J Cancer 104:882-5. 2011
    ..Little evidence is available on the relation of physical activity with colon adenomas, a colon cancer precursor...
  85. ncbi Application of a conversion factor to estimate the adenoma detection rate from the polyp detection rate
    Dawn L Francis
    Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota 55905, USA
    Gastrointest Endosc 73:493-7. 2011
    ..Many practices find it difficult to determine the ADR because it requires a combination of endoscopic and histologic findings. It may be possible to apply a conversion factor to estimate the ADR from the polyp detection rate (PDR)...
  86. pmc Magnifying colonoscopy as a non-biopsy technique for differential diagnosis of non-neoplastic and neoplastic lesions
    Shigeharu Kato
    Division of Gastrointestinal Oncology and Digestive Endoscopy, National Cancer Center Hospital East, Kashiwa 277 8577, Chiba, Japan
    World J Gastroenterol 12:1416-20. 2006
    ..To clarify whether mucosal crypt patterns observed with magnifying colonoscopy are feasible to distinguish non-neoplastic polyps from neoplastic polyps...
  87. ncbi High definition colonoscopy vs. standard video endoscopy for the detection of colonic polyps: a meta-analysis
    V Subramanian
    Nottingham Digestive Diseases Centre, Nottingham University Hospitals NHS Trust, Nottingham, United Kingdom
    Endoscopy 43:499-505. 2011
    ..The aim of this meta-analysis was to compare the diagnostic yield of colonic polyps between high definition colonoscopy and standard video endoscopy (SVE).
  88. pmc Recommendations for post-polypectomy surveillance in community practice
    David F Ransohoff
    Department of Medicine and Epidemiology, CB 7080, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7080, USA
    Dig Dis Sci 56:2623-30. 2011
    ..Decisions about surveillance interval are based in part on polyp size, histology, and number...
  89. ncbi Randomized double-blind trial of sulindac and etodolac to eradicate aberrant crypt foci and to prevent sporadic colorectal polyps
    Tetsuji Takayama
    Department of Gastroenterology and Oncology, Institutes of Health Biosciences, University of Tokushima Graduate School, Tokushima, Japan
    Clin Cancer Res 17:3803-11. 2011
    ....
  90. pmc Metformin efficacy and safety for colorectal polyps: a double-blind randomized controlled trial
    Takuma Higurashi
    Division of Gastroenterology, Yokohama City University School of Medicine, Yokohama, Japan
    BMC Cancer 12:118. 2012
    ..We devised a prospective randomized controlled trial to evaluate the chemopreventive effect of metformin against metachronous colorectal polyps and the safety of this drug in non-diabetic post-polypectomy patients...
  91. ncbi Endoscopic resection of large pedunculated colonic polyps and risk of postpolypectomy bleeding with adrenaline injection versus endoloop and hemoclip: a prospective, randomized study
    George Kouklakis
    Endoscopy Unit, Demokritus University of Thrace, Draganaa, 68100 Alexandroupolis, Greece
    Surg Endosc 23:2732-7. 2009
    Postpolypectomy bleeding is a major complication, especially in large pedunculated colonic polyps. Several endoscopic techniques have been evolved for prevention of bleeding episodes...
  92. ncbi Risk factors for sessile serrated adenomas
    Joseph Carl Anderson
    Department of Gastroenterology, University of Connecticut Health Center, Farmington, New Haven, CT 06030 1845, USA
    J Clin Gastroenterol 45:694-9. 2011
    ..Molecular abnormalities such as BRAF have been observed in SSA and smokers. Our hypothesis is that smoking may be associated with these lesions...
  93. ncbi High-resolution magnification chromoendoscopy: common problems encountered in "pit pattern" interpretation and correct classification of flat colorectal lesions
    D P Hurlstone
    Am J Gastroenterol 97:1069-70. 2002
  94. pmc Clinicopathologic and genetic characterization of traditional serrated adenomas of the colon
    Baojin Fu
    Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD 21231, USA
    Am J Clin Pathol 138:356-66. 2012
    ..However, conventional epithelial dysplasia and abnormal p53 labeling in a TSA are seen more often in the setting of BRAF mutation...
  95. ncbi Association between BMI and metabolic syndrome and adenomatous colonic polyps in Korean men
    Go Eun Lee
    Department of Preventive Medicine and Health Promotion, Asan Medical Center, Seoul, Korea
    Obesity (Silver Spring) 16:1434-9. 2008
    Obesity and insulin resistance are associated with the risk of colon cancer. Adenomatous colonic polyps are precancerous lesions of colon cancer...
  96. ncbi Endoscopic mucosal resection outcomes and prediction of submucosal cancer from advanced colonic mucosal neoplasia
    Alan Moss
    Department of Gastroenterology and Hepatology, Westmead Hospital, and Department of Biostatistics, School of Public Health, University of Sydney, Sydney, Australia
    Gastroenterology 140:1909-18. 2011
    Large sessile colonic polyps usually are managed surgically, with significant morbidity and potential mortality. There have been few prospective, intention-to-treat, multicenter studies of endoscopic mucosal resection (EMR)...
  97. ncbi A prospective, randomized comparison of adrenaline injection in combination with detachable snare versus adrenaline injection alone in the prevention of postpolypectomy bleeding in large colonic polyps
    Gregorios A Paspatis
    Department of Gastroenterology, Benizelion General Hospital, Heraklion Crete, Greece
    Am J Gastroenterol 101:2805; quiz 2913. 2006
    Our study sought to compare the efficacy of adrenaline injection in combination with detachable snare versus adrenaline injection alone in the prevention of postpolypectomy bleeding in large colonic polyps.
  98. ncbi Outcomes of a 5-year follow-up of patients with sessile serrated adenomas
    Anouar Teriaky
    Department of Medicine, The University of Western Ontario and London Health Sciences Centre, London, Ontario, Canada
    Scand J Gastroenterol 47:178-83. 2012
    ..Sessile serrated adenomas (SSAs) are precursors to colorectal cancer (CRC). The purpose of this study is to determine the occurrence of new polyps and CRC in patients with an SSA over a 5-year follow-up interval...
  99. ncbi Evaluation of autofluorescence colonoscopy for the detection and diagnosis of colonic polyps
    Audrey L McCallum
    Department of Surgical Gastroenterology, Gartnavel General Hospital, Glasgow, Scotland
    Gastrointest Endosc 68:283-90. 2008
    ..It, therefore, would be helpful to be able to differentiate between different polyps at a colonoscopy. Autofluorescence (AF) endoscopy has been developed to enhance conventional white light (WL) endoscopy in the diagnosis of GI lesions...
  100. ncbi Fibroblastic polyp of the colon and colonic perineurioma: 2 names for a single entity?
    Gabriel M Groisman
    Department of Pathology, Hillel Yaffe Medical Center, Hadera, Israel
    Am J Surg Pathol 32:1088-94. 2008
    ....
  101. ncbi Differential expression of microRNA 181b and microRNA 21 in hyperplastic polyps and sessile serrated adenomas of the colon
    Klaus Juergen Schmitz
    Institute of Pathology and Neuropathology, University Hospital Essen, University of Duisburg Essen, Hufelandstr 55, 45122, Essen, Germany
    Virchows Arch 455:49-54. 2009
    ..In contrast to HPs, SSAs are characterised by high levels of miR-181b and miR-21 expression. However, due to the overlap of values, miR-181b and miR-21 evaluation did not allow discrimination of the two lesions in every case...

Research Grants63

  1. Colon Polyp Screening with Colonoscopy in Women
    Philip Schoenfeld; Fiscal Year: 2005
    ..by applicant) My long term career goal is to identify the most effective techniques to screen patients for colonic polyps. Although the National Polyp Study indicated that endoscopic removal of colon polyps reduces colorectal cancer ..
  2. Colon Cancer Family Registry Cohort
    NORALANE MOREY LINDOR; Fiscal Year: 2013
    ..this in a cost-effective manner;and (ii) strategically collecting colonoscopy and pathology reports of colonic polyps when possible for high-risk participants (i.e...
  3. Analyses of Progression to Colon Cancer in a Spectrum of Pathways
    WILLIAM FRANKLIN DOVE; Fiscal Year: 2012
    Observation of human colonic polyps by virtual colonoscopy has indicated several possible fates: regression, stasis, growth, or progression...
  4. Dietary Marine Algae Extract and Colon Cancer Chemoprevention
    James Varani; Fiscal Year: 2010
    ..First, does the marine algae extract demonstrate efficacy against colonic hyperplasia, colonic polyps and colon carcinoma when used in a 15-month dietary study with genetcally "normal" mice on a high-fat Western ..
  5. NA-MIC virtual colonoscopy
    Hiroyuki Yoshida; Fiscal Year: 2012
    ..second leading cause of cancer deaths for men and women in the United States, can be prevented if precursor colonic polyps are detected and removed...
  6. Computerized Detection of Polyps in CT Colonography
    Hiroyuki Yoshida; Fiscal Year: 2009
    ..second leading cause of cancer deaths for men and women in the United States, can be prevented if precursor colonic polyps are detected and removed...
  7. Dual-energy Electronic-cleansing CT Colonography for Colon Cancer Screening
    Hiroyuki Yoshida; Fiscal Year: 2013
    ..Thus, the proposed research will substantially raise the screening rate and the early detection of colonic polyps and cancers.
  8. CALCIUM AND COLORECTAL EPITHELIAL CELL PROLIFERATION
    John Potter; Fiscal Year: 1992
    ..by tritiated thymidine [3H]dTh - labeling of the cells as a biomarker or potential precursor lesion for colonic polyps and colonic cancer...
  9. AUTOMATIC COLON SEGMENTATION FOR 3D VIRTUAL COLONOSCOPY
    JEROME LIANG; Fiscal Year: 1999
    ..Since there is a known progression of colonic polyps toward malignant carcinoma, detection and removal of small polyps can totally cure patients...
  10. Colon Cancer Screening Augmented by Image Processing
    Michael Zalis; Fiscal Year: 2006
    ..CT Colonography (CTC, or "Virtual Colonoscopy") is a sensitive method for detecting clinically significant colonic polyps. However, the technique currently suffers two limitations: 1) patients are still required to undergo cleansing ..
  11. Epidemiology of Loss of Imprinting in Colorectal Cancer
    Marcia Cruz Correa; Fiscal Year: 2005
    ..An explorative study to evaluate the prevalence of LOI in people with normal colons, and those with colonic polyps and cancer is proposed using a cross-sectional study design, followed by a prospective cohort of patients with ..
  12. PHASE I CHEMOPREVENTION USING DFMO TO MODULATE ODC
    Gordon Luk; Fiscal Year: 1991
    ..proliferation and the possible associated reduction in neoplastic transformation and progression of the colonic polyps. We have completed pilot studies in 5 patients with familial polyposis who were given DFMO for 7 days...
  13. APC TUMOR SUPPRESSOR PATHWAY IN EXTRACOLONIC TISSUES
    Alan Yahanda; Fiscal Year: 2000
    ..of individuals with APC mutations that do not have the typical phenotype, and instead, have few or absent colonic polyps and numerous extracolonic tumors...
  14. A MODEL FOR COLONIC CANCER-ASSOCIATED ANTIGENS
    KESHAB PANT; Fiscal Year: 1980
    ..has been found to be quantitatively increased in rapidly proliferating gastrointestinal tissues, especially colonic polyps and carcinomas, and has also been found to circulate in the blood of patients with colonic cancer...
  15. PLASMA MEMBRANE INVOLVEMENT IN MALIGNANCY AND METASTASIS
    Carolyn Mountford; Fiscal Year: 1992
    ..changes which are measurable by magnetic resonance methods during tumor development from early stages of colonic polyps. This information is imperative for the optimal usage of magnetic resonance imaging and spectroscopy for the ..
  16. Phase III Colon Cancer Prevention Trial
    Frank Meyskens; Fiscal Year: 2006
    ..The major objectives of this investigation are to reduce the recurrence rate of adenomatous colonic polyps without producing toxicity greater than that seen in the placebo group...
  17. CORI: Consortium Expansion and Database Enhancement
    David Lieberman; Fiscal Year: 2004
    ....
  18. Screening for colortectal cancer in an Asian Community Center
    David Lieberman; Fiscal Year: 2008
    ..This is a new paradigm for screening, which takes advantage of the trust and cultural awareness that exists at the community center and does not rely on the primary care provider. [unreadable] [unreadable] [unreadable] [unreadable]..
  19. Serum 25(OH)D, Vitamin D Intake, and Breast Cancer Recurrence in the WHEL Study
    Elizabeth T Jacobs; Fiscal Year: 2010
    ....
  20. 3D Massive Training ANN for CAD for Colon Cancer in CT Colonography
    Kenji Suzuki; Fiscal Year: 2010
    ....
  21. Regulation of Stellate Cell Contractility
    Don Rockey; Fiscal Year: 2008
    ..Physiologic endpoints will be an important focus. The proposed studies will shed light on the molecular basis of stellate cell contractility and moreover have direct relevance to human liver disease. ..
  22. METHYLATION PROFILING AND RISK OF COLORECTAL CANCER
    Hassan Ashktorab; Fiscal Year: 2007
    ..These studies will help in the detection and _rofiling of genetic changes in the pathway of CRC in AA. ..
  23. PATHOGENESIS OF HEPATIC FIBROSIS AND PORTAL HYPERTENSION
    Don C Rockey; Fiscal Year: 2010
    ..These studies have direct relevance to human liver disease and will lead to new approaches for the treatment of hepatic fibrosis and portal hypertension as well as other forms of fibrosing injury. ..
  24. Fiber and Colorectal Adenomas: A Pooling Project
    Elizabeth Jacobs; Fiscal Year: 2005
    ..If it is found that certain groups may receive greater benefit from fiber, then public health recommendations can be made which target these groups and prevent the recurrence of colorectal adenomas. ..
  25. Mechanisms of Growth Inhibition by Helicobacter Pylor
    Hassan Ashktorab; Fiscal Year: 2003
    ..These studies will help to establish how bacteria can increase apoptosis possibly through generation of ROS and in specific circumstances this may alter one's risk of developing cancer. ..
  26. Nitric Oxide and the Liver
    Don Rockey; Fiscal Year: 2003
    ..The dates of the entire AASLD scientific meeting are November 3rd to November 5th. The participants will be invited speakers and attendees of the annual 2002 AASLD meeting. ..
  27. PROSPECTIVE COMPARISON OF COLONIC IMAGING TEST
    Don Rockey; Fiscal Year: 2001
    ..The information gained from this study is expected to form the basis for national policy and decision making with reward to colonic imaging tests. ..
  28. PREMALIGNANT LESIONS OF THE GI TRACT
    Harold Frucht; Fiscal Year: 1999
    ..Among the topics to be covered are Barrets Esophagus, Helicobacter Pylori, Hereditary Pancreatitis, Pancreatic Dysplasia, Hereditary Colon Cancer Syndromes, Genetic Testing and Counseling, Inflammatory Bowel Disease and Colonic Polyps.
  29. Colonoscopy quality and outcomes in clinical practice
    Cynthia W Ko; Fiscal Year: 2010
    ..The various algorithms we develop will be tested in a second, validation subset of our database to find the algorithm with optimal performance characteristics. ..
  30. Exercise effects on oxidative damage among women
    Cornelia Ulrich; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  31. Genetic Study of Prostaglandin Synthesis/EGFR and Risk of Colorectal Neoplasia
    Cornelia Ulrich; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  32. Modeling Folate, One-Carbon Metabolism & DNA Methylation
    Cornelia Ulrich; Fiscal Year: 2007
    ..We plan to make the model generally available to the research community, and anticipate that it will become a useful tool that can be used as an adjunct to experimental investigations and as an aid to study design. ..
  33. The effect of physical activity on metabolic syndrome in pregnancy and fetal outc
    Cynthia Ko; Fiscal Year: 2008
    ..It may offer a safe and readily available method to control weight and improve infant health during and after pregnancy. [unreadable] [unreadable] [unreadable]..
  34. Dectection of occult mediastinal lymph node mestastases
    Michael Wallace; Fiscal Year: 2007
    ..In the R33 component of the grant application these criteria will be prospectively evaluated and correlated with clinical outcome in a second, larger cohort of patients. ..
  35. Cathartic-Free Dual-Energy CT Colonography
    Jeff Fidler; Fiscal Year: 2006
    ..The investigators have world-class expertise and resources in CT colonography, dual energy algorithms, and CT system calibrations. [unreadable] [unreadable]..
  36. Prostaglandin Synthesis, Genetics and Colorectal Cancer
    Cornelia M Ulrich; Fiscal Year: 2010
    ..They will also advance tailoring of chemoprevention in a way that maximizes benefit and minimizes toxicity. ..
  37. A Primary-Care Based Colorectal Cancer Screening Program
    Cynthia Ko; Fiscal Year: 2006
    ..If successful, this program may be useful to other large primary care practices, and may also help to improve utilization of other types of cancer prevention services ..
  38. Randomized Trial of EUS Neurolysis in Pancreas Cancer
    Michael Wallace; Fiscal Year: 2006
    ..The primary outcome will be a reduction in pain at 1 month. Secondary outcomes will include the durability of pain control, quality of life, narcotic use and narcotic side effects. [unreadable] [unreadable]..
  39. Epidemiology of hepatocellular carcinoma
    Cynthia Ko; Fiscal Year: 2006
    ....
  40. NSAID and COX/PG Metabolism and Colorectal Cancer
    Cornelia Ulrich; Fiscal Year: 2009
    ..Ultimately, such information on the metabolic variation will be useful in optimizing NSAIDs and NSAID regimens and will allow individual tailoring of chemoprevention. ..
  41. POLYMORPHISMS IN PG/COX PATHWAY AND COLORECTAL POLYPS
    Cornelia Ulrich; Fiscal Year: 2003
    ..Finally, we plan to develop a model for integrating information on genetic variability at multiple points in this metabolic pathway. ..
  42. PPAR-gamma ligands in colorectal cancer
    Seung Joon Baek; Fiscal Year: 2010
    ..IV. To investigate the in vivo anti-tumorigenic effects of a novel PPARy ligand, MCC-555, and its affects on NAG-1 expression at different stages of colorectal carcinogenesis. ..
  43. Insulin Resistance and Adenomas of the Colorectum
    Theodore Levin; Fiscal Year: 2003
    ..abstract_text> ..
  44. Large Database Research for Cancer Prevention & Control
    Gregory Cooper; Fiscal Year: 2006
    ..abstract_text> ..
  45. QUANTITATIVE SPECT RECONSTRUCTION OF THE CHEST
    JEROME LIANG; Fiscal Year: 2001
    ..Diagnosis of CAD, as well as pulmonary embolism and breast cancer will be assessed ..
  46. High Intensity Ultrasound in Gastroenterology
    JOO HWANG; Fiscal Year: 2003
    ..It is anticipated that this work will help to gain a better understanding of the mechanisms of HIFU and its potential role for other GI applications such as tumor therapy. ..
  47. CLINICAL RESEARCH CURRICULUM
    David Ransohoff; Fiscal Year: 2004
    ..abstract_text> ..
  48. Improving Surveillance for Colorectal Polyps
    John Ayanian; Fiscal Year: 2006
    ..This study will provide a model for evaluating how data from electronic medical records can be used to improve screening of patients with prior colorectal polyps who are at increased risk of developing recurrent polyps or cancer. ..
  49. Anti-cancer effects by the green tea catechins
    SEUNG BAEK; Fiscal Year: 2006
    ..2. Profile changes in gene expression following ECG treatment. 3. Compare the preventative and therapeutic efficacy of individual and combination catechins in animal models of colorectal cancer. ..
  50. Health Behaviors and Family History of Colorectal Cancer
    Lisa Madlensky; Fiscal Year: 2005
    ....
  51. Training Program in Academic Gastroenterology
    Gregory Cooper; Fiscal Year: 2006
    ..After that, 1 or 2 subsequent years may be offered to selected trainees, to be supported by other individual or institutional training grants, or grants to which the trainee will apply during his/her official training period. ..
  52. Wnt Signaling in IBD-Related Colon Cancer
    RANDALL HOLCOMBE; Fiscal Year: 2005
    ..The precise effects of FIPs on Wnt signaling will be defined in vitro, with attention to the potentially disparate responses of different, specific, Fz receptor subtypes. ..
  53. CTC of the Unprepped Colon: Optimization and Validation
    C Johnson; Fiscal Year: 2006
    ..Data generated should provide for a balanced appraisal of the value and practicality of this revolutionary and potentially powerful unique screening tool. ..
  54. Colonoscopy Utilization in North Carolina
    David Ransohoff; Fiscal Year: 2006
    ..It may provide the basis to develop interventions to optimize the allocation of colonoscopy effort in programs of CRC screening and surveillance. ..
  55. CHEMOPREVENTION OF ADENOMATOUS COLORECTAL POLYPS
    HANS BERKEL; Fiscal Year: 2004
    ..The apoptotic (Tunel technique) and mitotic (H&E) indices, KI67, COX-2, as well as APC gene, and K-ras mutations (immunohistochemistry) will be measured as surrogate endpoint markers. ..
  56. Oxidative Stress, Antioxidants and Breast Cancer Risk
    Qi Dai; Fiscal Year: 2007
    ..Findings from this study will have important public health implications in the primary prevention of breast cancer. [unreadable] [unreadable] [unreadable]..
  57. Predictors of Menarche
    Lindsay Frazier; Fiscal Year: 2004
    ..Understanding the predictors of menarche will help to develop a public health approach to the issue of early pubertal development. ..
  58. Improving Systems for Colorectal Cancer Screening
    John Ayanian; Fiscal Year: 2008
    ..abstract_text> ..
  59. Calcitriol for Chemoprevention in Preinvasive Bronchial Epithelial Lesions
    Mary Reid; Fiscal Year: 2008
    ..abstract_text> ..
  60. Genetics of Serrated Neoplasia
    Joanne Young; Fiscal Year: 2009
    ..In this proposal, we will explore the notion that the predisposition to form hyperplastic polyps may be inherited in families. ..