Genomes and Genes
Summary: Discrete abnormal tissue masses that protrude into the lumen of the INTESTINE. A polyp is attached to the intestinal wall either by a stalk, pedunculus, or by a broad base.
Publications228 found, 100 shown here
- Chemoprevention of intestinal tumorigenesis in APCmin/+ mice by silibininSubapriya Rajamanickam
Department of Pharmaceutical Sciences, School of Pharmacy and University of Colorado Cancer Center, University of Colorado Denver, Aurora, Colorado 80045, USA
Cancer Res 70:2368-78. 2010..o. silibinin feeding against spontaneous intestinal tumorigenesis in the APC(min/+) mice model, suggesting its chemopreventive potential against intestinal cancers including CRC...
- Eicosapentaenoic acid reduces rectal polyp number and size in familial adenomatous polyposisNicholas J West
Section of Molecular Gastroenterology, Leeds Institute of Molecular Medicine, St James s University Hospital, Leeds, UK
Gut 59:918-25. 2010....
- Serrated and non-serrated polyps of the colorectum: their prevalence in an unselected case series and correlation of BRAF mutation analysis with the diagnosis of sessile serrated adenomaN J Carr
Graduate School of Medicine, University of Wollongong, New South Wales, Australia
J Clin Pathol 62:516-8. 2009..To determine the prevalence of colorectal polyps of different types in an unselected population, and to correlate the morphological diagnoses with BRAF mutation analysis...
- ERK activation drives intestinal tumorigenesis in Apc(min/+) miceSung Hee Lee
Department of Medicine, University of California, San Diego, La Jolla, California, USA
Nat Med 16:665-70. 2010..Our data reveal a new facet of oncogene-environment interaction, in which microflora-induced TLR activation regulates oncogene expression and related IEC tumor growth in a susceptible host...
- A role for the epidermal growth factor receptor signaling in development of intestinal serrated polyps in mice and humansGerold Bongers
Immunology Institute, Mount Sinai School of Medicine, New York, New York 10029 6574, USA
Gastroenterology 143:730-40. 2012..Tumors that arise from these polyps frequently contain activating mutations in BRAF or KRAS, but little is known about the role of EGFR activation in their development...
- [Contribution of coloscopy to diagnosis of rectal bleeding in Dakar (Senegal)]M Mbengue
Service d Hepato Gastroenterologie, CHU Aristide Le Dantec Dakar, Senegal
Med Trop (Mars) 69:286-8. 2009..The purpose of this report is to describe lesions discovered by coloscopy in patients assessed for rectal bleeding in Dakar, Senegal...
- Promoter methylation of the mutated in colorectal cancer gene is a frequent early event in colorectal cancerM R J Kohonen-Corish
Cancer Research Program, Garvan Institute of Medical Research, Sydney, New South Wales, Australia
Oncogene 26:4435-41. 2007..Furthermore, MCC methylation is significantly associated with a distinct spectrum of precursor lesions, which are suggested to give rise to cancers via the serrated neoplasia pathway...
- Sessile serrated adenomas: prevalence of dysplasia and carcinoma in 2139 patientsRichard H Lash
Caris Research Institute, Irving, Texas, USA
J Clin Pathol 63:681-6. 2010..This study attempts to estimate the progression rate of SSAs based upon the epidemiology of a large cohort as well as identify relationships to other colorectal polyps...
- Chemopreventive effects of dietary folate on intestinal polyps in Apc+/-Msh2-/- miceJ Song
Department of Nutritional Sciences, University of Toronto, Ontario, Canada
Cancer Res 60:3191-9. 2000....
- Sessile serrated adenoma: challenging discrimination from other serrated colonic polypsAlton B Farris
Department of Pathology, Biostatistics Center, Massachusetts General Hospital, Boston, MA, USA
Am J Surg Pathol 32:30-5. 2008..However, this level of variability is acceptable because the presence of SSA indicates increased risk of developing additional serrated polyps and carcinoma, and surveillance is appropriate...
- Molecular features of colorectal hyperplastic polyps and sessile serrated adenoma/polyps from KoreaKyoung Mee Kim
Department of Pathology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea
Am J Surg Pathol 35:1274-86. 2011..left) may be a more significant risk factor of progression than the histologic type of polyp. Our data also support the theory that right-sided MVHPs may be a precursor to SSA/P...
- Beef induces and rye bran prevents the formation of intestinal polyps in Apc(Min) mice: relation to beta-catenin and PKC isozymesM Mutanen
Department of Applied Chemistry and Microbiology Nutrition, PO Box 27, University of Helsinki, Helsinki, FIN 00014, Finland
Carcinogenesis 21:1167-73. 2000..different grain fibers as well as inulin, polydisperse beta(2-->1) fructan, could affect the formation of intestinal polyps in Apc(Min) mice...
- Endoscopic mucosal resection of 161 cases of large sessile or flat colorectal polypsNaila Arebi
St Mark s Hospital, London, UK
Scand J Gastroenterol 42:859-66. 2007..The aim of this study was to identify the factors that may be predictive of the risk of polyp recurrence...
- [Lgr5 and CD44 expressions in different types of intestinal polyps and colorectal cancer]Ningli Chai
Department of Gastroenterology, General Hospital of PLA, Beijing, China
Nan Fang Yi Ke Da Xue Xue Bao 33:972-6. 2013To study the expression of tumorigenesis-related stem cell markers Lgr5 and CD44 in different pathological types of intestinal polyps and their clinical significance in predicting tumorigenesis.
- A fish oil derived concentrate enriched in eicosapentaenoic and docosahexaenoic acid as ethyl ester suppresses the formation and growth of intestinal polyps in the Min mouseJ E Paulsen
Department of Environmental Medicine, National Institute of Public Health, Oslo, Norway
Carcinogenesis 18:1905-10. 1997..8 +/- 0.9) and the crypt multiplicity (1.49 +/- 0.28) in females were reduced by 73% (P = 0.03) and 60% (P = 0.048) with 2.5% of K85, respectively, whereas no significant effect could be observed in the males...
- Peroxisome proliferator-activated receptor ligand MCC-555 suppresses intestinal polyps in ApcMin/+ mice via extracellular signal-regulated kinase and peroxisome proliferator-activated receptor-dependent pathwaysKiyoshi Yamaguchi
Department of Pathobiology, College of Veterinary Medicine, The University of Tennessee, 2407 River Drive, Knoxville, TN 37996, USA
Mol Cancer Ther 7:2779-87. 2008..Subsequently, treatment with MCC-555 (30 mg/kg/d) for 4 weeks reduced the number of small intestinal polyps to 54.8% of that in control mice...
- Overexpression of low-density lipoprotein receptor and lipid accumulation in intestinal polyps in Min miceMichihiro Mutoh
Cancer Prevention Basic Research Project, National Cancer Center Research Institute, Tokyo, Japan
Int J Cancer 125:2505-10. 2009..lipase (LPL), high concentration of serum triglyceride (TG), fatty change of the liver and large numbers of intestinal polyps. We have reported that induction of LPL expression reduces serum lipid, especially TG, improves fatty change ..
- Chemoprevention of intestinal polyps in ApcMin/+ mice fed with western or balanced diets by drinking annurca apple polyphenol extractLucia Fini
Department of Internal Medicine, Baylor Research Institute, Sammons Cancer Center, USA
Cancer Prev Res (Phila) 4:907-15. 2011....
- Serrated polyps of the colorectum: is sessile serrated adenoma distinguishable from hyperplastic polyp in a daily practice?Dominique Sandmeier
Institute of Pathology, Centre Hospitalier Universitaire Vaudois, Bugnon 25, CH 1011 Lausanne, Switzerland
Virchows Arch 450:613-8. 2007..One SSA of our series showed low-grade dysplasia supporting the concept that this lesion might be a precursor of serrated adenocarcinoma...
- Cancer chemoprevention of intestinal polyposis in ApcMin/+ mice by sulforaphane, a natural product derived from cruciferous vegetableRong Hu
Department of Pharmaceutics, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA
Carcinogenesis 27:2038-46. 2006....
- Hyperplastic polyps, serrated adenomas, and the serrated polyp neoplasia pathwayChristopher S Huang
Section of Gastroenterology, Boston Medical Center, Boston, Massachusetts 02118, USA
Am J Gastroenterol 99:2242-55. 2004
- Serrated polyps of the large intestine: a morphologic and molecular review of an evolving conceptDale C Snover
Department of Pathology, Fairview Southdale Hospital, Edina, MN 55435, USA, and McGill University, Montreal, Canada
Am J Clin Pathol 124:380-91. 2005....
- Loss of Apc heterozygosity and abnormal tissue building in nascent intestinal polyps in mice carrying a truncated Apc geneM Oshima
Banyu Tsukuba Research Institute Merck, Japan
Proc Natl Acad Sci U S A 92:4482-6. 1995..It is therefore unlikely that the truncated product interacts directly with the wild-type protein and causes the microadenomas by a dominant negative mechanism...
- A randomised, double blind, placebo controlled study of celecoxib, a selective cyclooxygenase 2 inhibitor, on duodenal polyposis in familial adenomatous polyposisR K S Phillips
Colorectal Cancer Unit, Imperial Cancer Research Fund, London, UK
Gut 50:857-60. 2002....
- The patient with multiple intestinal polypsKarsten Schulmann
Ruhr University Bochum, Medical Department, Knappschaftskrankenhaus, Bochum, Germany
Best Pract Res Clin Gastroenterol 21:409-26. 2007The management of patients with multiple intestinal polyps may be difficult and greatly depends on the correct classification. Polyposis syndromes account for less than 1% of newly diagnosed colorectal cancers...
- Fractal and image analysis of the microvasculature in normal intestinal submucosa and intestinal polyps in Apc(Min/+) miceJohn W Fuseler
Department of Cell Biology and Anatomy, University of South Carolina School of Medicine, Columbia, SC 29209, USA
Microsc Microanal 16:73-9. 2010..analysis to quantify differences in the complexity of the vasculature in normal intestinal submucosa and intestinal polyps. Apc(Min/+) mice and wild-type mice were perfused with a curable latex compound, intestines sectioned, and ..
- Cyclooxygenase-2 expression in fibroblasts and endothelial cells of intestinal polypsMasahiro Sonoshita
Department of Pharmacology, Graduate School of Medicine, Kyoto University, Kyoto 606 8501, Japan
Cancer Res 62:6846-9. 2002..By immunohistochemical analysis, here we show that the majority of COX-2-expressing cells in the intestinal polyps of Apc(Delta716) mice are fibroblasts and endothelial cells...
- Chemoprevention of intestinal polyposis in the Apcdelta716 mouse by rofecoxib, a specific cyclooxygenase-2 inhibitorM Oshima
Tsukuba Research Institute, Banya Pharmaceutical Co, Ltd, Japan
Cancer Res 61:1733-40. 2001..Although homozygote Apc-/- mice are embryonically lethal, the heterozygotes are viable but develop numerous intestinal polyps with loss of Apc heterozygosity within the polyps (M. Oshima et al., Proc. Natl. Acad. Sci...
- Cross-species comparison of human and mouse intestinal polyps reveals conserved mechanisms in adenomatous polyposis coli (APC)-driven tumorigenesisClaudia Gaspar
Dept of Pathology, Erasmus MC, PO Box 2040, 3000CA Rotterdam, The Netherlands
Am J Pathol 172:1363-80. 2008..Here, we applied a cross-species comparison of expression profiles of intestinal polyps derived from hereditary colorectal cancer patients carrying APC germline mutations and from mice carrying a ..
- Cyclooxygenase 2- and prostaglandin E(2) receptor EP(2)-dependent angiogenesis in Apc(Delta716) mouse intestinal polypsHiroshi Seno
Department of Pharmacology, Kyoto University Graduate School of Medicine, Kyoto 606 8501, Japan
Cancer Res 62:506-11. 2002....
- Efficacy, risk factors and complications of endoscopic polypectomy: ten year experience at a single centerPierluigi Consolo
Department of Medicine and Pharmacology, University Hospital G Martino, Via Consolare Valeria, Messina 98100, Italy
World J Gastroenterol 14:2364-9. 2008..To examine the efficacy and complications of colonoscopic resection of colorectal polypoid lesions...
- Occult colorectal polyps on CT colonography: implications for surveillanceRobert L MacCarty
Mayo Clinic, Mayo Medical School, Mary Clinic E 2, 200 First St SW, Rochester, MN 55905, USA
AJR Am J Roentgenol 186:1380-3. 2006..Differences in the prevalence of occult polyps in various populations might help explain the discordant reported sensitivities for polyp detection in published reports of CTC...
- Suppression of intestinal polyps in Msh2-deficient and non-Msh2-deficient multiple intestinal neoplasia mice by a specific cyclooxygenase-2 inhibitor and by a dual cyclooxygenase-1/2 inhibitorG Lal
Centre for Cancer Genetics, Samuel Lunenfeld Research Institute, Department of Surgery, Mount Sinai Hospital, University of Toronto, Toronto, Ontario, M5G 1X5 Canada
Cancer Res 61:6131-6. 2001..overexpressed in adenomas and colorectal cancers, and COX-2-specific inhibitors have been shown to inhibit intestinal polyps in Apc(Delta716) mice more effectively than dual COX-1/COX-2 inhibitors such as sulindac...
- Pharmacogenomics of cancer chemopreventive isothiocyanate compound sulforaphane in the intestinal polyps of ApcMin/+ miceTin Oo Khor
Department of Pharmaceutics, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA
Biopharm Drug Dispos 27:407-20. 2006..Recently it was found that SFN could also suppress the growth of intestinal polyps in the ApcMin/+ mouse...
- CT colonography at different radiation dose levels: feasibility of dose reductionRogier E van Gelder
Department of Radiology, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
Radiology 224:25-33. 2002..To investigate the sensitivity and specificity of polyp detection and the image quality of computed tomographic (CT) colonography at different radiation dose levels and to study effective doses reported in literature on CT colonography...
- Wireless capsule endoscopy in detecting small-intestinal polyps in familial adenomatous polyposisPanagiotis Katsinelos
Department of Endoscopy and Motility Unit, Central Hospital, Ethnikis Aminis 41, 54635, Thessaloniki, Greece
World J Gastroenterol 15:6075-9. 2009..To detect the prevalence of small bowel polyps by wireless capsule endoscopy (WCE) in patients with familial adenomatous polyposis (FAP)...
- The role of cyclooxygenase-2 (COX-2) in two different morphological stages of intestinal polyps in APC(Delta474) knockout miceKen ichi Sunayama
2nd Department of Surgery, Hamamatsu University School of Medicine, 1 20 1 Handayama, Hamamatsu, 431 3192, Japan
Carcinogenesis 23:1351-9. 2002....
- Sessile serrated adenoma (SSA) vs. traditional serrated adenoma (TSA)Emina Emilia Torlakovic
Department of Pathology, Royal University Hospital, University of Saskatchewan, Saskatoon, SK, Canada
Am J Surg Pathol 32:21-9. 2008....
- Conventional colonoscopy and magnified chromoendoscopy for the endoscopic histological prediction of diminutive colorectal polyps: a single operator studyGiovanni D De Palma
DUN Chirurgia Generale e Tecnologie Avanzate, AOU Federico II, Facolta di Medicina e Chirurgia, Via Pansini, 5, 80131 Napoli, Italy
World J Gastroenterol 12:2402-5. 2006..To accurately differentiate the adenomatous from the non-adenomatous polyps by colonoscopy...
- Consider colonoscopy for young patients with hematocheziaRobert F Wong
Division of Gastroenterology, 4R 118 SOM, University of Utah Medical Center, 50 North Medical Drive, Salt Lake City, UT 84132, USA
J Fam Pract 53:879-84. 2004..Hematochezia is a common complaint in adult patients aged <50 years. Most studies of lower endoscopy for rectal bleeding have concentrated on older patients or have failed to mention the location of lesions...
- [Endoscopic treatment of colorectal polyps in a digestive endoscopy outpatient department]Giorgio Romano
Divisione di Chirurgia Generale, dell Uremico e dei Trapianti d Organo, Facolta di Medicina e Chirurgia, Universita degli Studi di Palermo
Chir Ital 56:669-73. 2004..We therefore conclude that colonoscopy allows not only early diagnosis of colonic neoplasms, but also radical curative treatment in the early stages...
- An unusual complication: postcolonoscopy appendicitisR Pellish
Department of Medicine, Division of Gastroenterology, Brown Medical School, Rhode Island Hospital, Providence, Rhode Island, USA
Endoscopy 39:E138. 2007
- Six-year prospective analysis of the rectal bleeding clinic at the Queen Elizabeth Hospital, Adelaide, South AustraliaJen S J Lee
Colorectal Unit, Division of Surgery, The University of Adelaide Discipline of Surgery, The Queen Elizabeth Hospital, Woodville, South Australia, Australia
ANZ J Surg 77:553-6. 2007..The Queen Elizabeth Hospital RBC is an open access clinic and is unique in South Australia. It offers flexible sigmoidoscopy and facilities for treating common anorectal conditions...
- Is endoscopic polypectomy an adequate therapy for malignant colorectal adenomas? Presentation of 114 patients and review of the literatureU Seitz
Interdisciplinary Endoscopy, University Hospital Eppendorf, Hamburg, Germany
Dis Colon Rectum 47:1789-96; discussion 1796-7. 2004..This study was designed to evaluate the outcome of endoscopic polypectomy of malignant polyps with and without subsequent surgery based on histologic criteria...
- Magnifying chromoendoscopy: effective diagnostic tool for screening colonoscopyRalf Kiesslich
J Gastroenterol Hepatol 22:1700-1. 2007
- Further validation of magnifying chromocolonoscopy for differentiating colorectal neoplastic polyps in a health screening centerFabian Emura
Division of Endoscopy, National Cancer Center Hospital, Tokyo, Japan
J Gastroenterol Hepatol 22:1722-7. 2007..This study aimed to further validate the effectiveness of magnifying chromocolonoscopy in the diagnosis of neoplastic colorectal polyps in a screening center...
- Detachable snare versus epinephrine injection in the prevention of postpolypectomy bleeding: a randomized and controlled studyP Di Giorgio
Gastrointestinal Endoscopy Unit, Pellegrini Hospital, Naples, Italy
Endoscopy 36:860-3. 2004..Several endoscopic techniques have been developed to prevent bleeding after the removal of large pedunculated polyps...
- Endoloop-assisted polypectomy for large pedunculated colorectal polypsP Katsinelos
Department of Endoscopy and Motility Unit, Central Hospital, Ethnikis Aminis 41, 546 35, Thessaloniki, Greece
Surg Endosc 20:1257-61. 2006....
- Colonoscopy: as good as gold?David Lieberman
Ann Intern Med 141:401-3. 2004
- Location of adenomas missed by optical colonoscopyPerry J Pickhardt
Department of Radiology, University of Wisconsin Medical School, E3 311 Clinical Science Center, 600 Highland Avenue, Madison, WI 53792 3252, USA
Ann Intern Med 141:352-9. 2004..Previous estimates of the adenoma miss rate with optical colonoscopy (OC) are hindered by the use of OC as its own reference standard...
- EMR of large sessile colorectal polypsMassimo Conio
Department of Gastroenterology, National Institute for Cancer Research, Via Trento 42 14, 16145 Genoa, Italy
Gastrointest Endosc 60:234-41. 2004..EMR optimizes histopathologic assessment of resected lesions. This study evaluated the outcome of EMR of large sessile colorectal polyps in terms of complications and recurrence...
- Detection of colorectal polyps by multislice CT colonography with ultra-low-dose technique: comparison with high-resolution videocolonoscopyChristoph Vogt
Division of Medicine, Department of Gastroenterology, Hepatology and Infectious Diseases, Institute of Diagnostic Radiology, Heinrich Heine University of Dusseldorf, Moorenstrasse 5, D 40225 Dusseldorf, Germany
Gastrointest Endosc 60:201-9. 2004..This prospective study compared multislice CT colonography with ultra-low-dose technique to high-resolution videocolonoscopy as the standard for detection of colorectal cancer and polyps...
- Utility of MIB-1 (Ki-67) in evaluating diminutive colorectal polyps with cautery artifactGabriel M Groisman
Department of Pathology, Hillel Yaffe Medical Center, Hadera 38100, Israel
Arch Pathol Lab Med 131:1089-93. 2007..However, interpretation of diminutive colorectal polyps removed by thermal electrocoagulation (hot biopsy technique) is often problematic as a result of cautery artifact...
- Colorectal polypectomy and risk of colorectal cancer by subsite: the Fukuoka Colorectal Cancer studyDaigo Yoshida
Department of Preventive Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
Jpn J Clin Oncol 37:597-602. 2007..However, benefit of colorectal polypectomy in routine practice is still uncertain. We therefore investigated subsite-specific risks of colorectal cancer in relation to history of colorectal polypectomy in a case-control study...
- An evaluation of colorectal endoscopic mucosal resection using high-magnification chromoscopic colonoscopy: a prospective study of 1000 colonoscopiesD P Hurlstone
Gastroenterology and Liver Unit, Royal Hallamshire Hospital, Sheffield, United Kingdom
Endoscopy 36:491-8. 2004..The aim of the present study was to assess the efficacy and safety of en-bloc endoscopic mucosal resection with high-magnification chromoendoscopy in the management of sessile and flat colorectal lesions </= 20 mm...
- Safety and efficacy of argon plasma coagulator ablation therapy for flat colorectal adenomasA Garcia
Unit of Gastrointestinal Endoscopy, Department of Digestive Diseases, Hospital Gregorio Maranon, Madrid, Spain
Rev Esp Enferm Dig 96:315-21. 2004..argon-plasma coagulation (APC) has been used safely and efficaciously in multiple settings including colon polyp treatment. The aim of this study was to evaluate APC efficacy and safety in the treatment of flat colorectal adenomas...
- Do serrated adenomas have higher malignant potential than traditional adenomas?Bing Zou
J Gastroenterol Hepatol 22:1701-3. 2007
- [Colorectal polyps and colorectal cancer]Jie Zheng
Zhonghua Bing Li Xue Za Zhi 34:4-5. 2005
- Low rate of microsatellite instability in young patients with adenomas: reassessing the Bethesda guidelinesFernando S Velayos
Division of Gastroenterology and Colorectal Cancer Prevention Program, University of California, San Francisco, CA, USA
Am J Gastroenterol 100:1143-9. 2005..We sought to determine the rate of MSI in adenomas removed from individuals under 40 yr of age over a 5-yr period in a university general gastroenterology practice...
- The usefulness of colonoscopy as a screening test for detecting colorectal polypsDae Han Kim
Division of Gastroenterology, Department of Internal Medicine Korea Institute of Radiological and Medical Sciences, Seoul, Korea
Hepatogastroenterology 54:2240-2. 2007..Colonic polyps are the most common lesions encountered during screening colonoscopy. The purpose of this study is to evaluate the usefulness of colonoscopy to detect colonic polyps in adults...
- [Effectiveness of screening colonoscopy in a community-based study]D Hüppe
Gastroenterologische Gemeinschaftspraxis Herne, Herne
Z Gastroenterol 46:193-200. 2008..Screening colonoscopy detects colorectal cancers in the early stages. Given the favourable prognosis in these stages, screening can reduce CRC-related mortality...
- Endoscopic mucosal resection (EMR) in the management of large colo-rectal polypsJ K A Jameel
Academic Surgical Unit, University of Hull, Hull, UK
Colorectal Dis 8:497-500. 2006..Endoscopic Mucosal Resection (EMR) may significantly reduce this risk. We aim to assess the safety and efficacy of EMR in our unit...
- [Distal hyperplastic polyps as a marker for advanced neoplasm of the proximal colon. Our experience]M Zippi
Struttura Complessa di Gastroenterologia ed Endoscopia Digestiva, Ospedale Sandro Pertini, Roma, Italia
Clin Ter 158:421-4. 2007..The aim of this study was to investigate, retrospectively, the possible correlation between the distal hyperplastic polyps and proximal colorectal neoplasia...
- Update on colorectal cancer imagingMarc J Gollub
Department of Radiology, Weill Medical College of Cornell University, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
Radiol Clin North Am 45:85-118. 2007..Staging with CT, MR imaging, endorectal ultrasound, and positron emission tomography are of paramount importance in determining the most appropriate therapy and the risk of tumor recurrence and overall prognosis...
- Understanding current guidelines for colorectal cancer screening: a case-based approachLaura K Bianchi
Division of Gastroenterology, Evanston Northwestern Healthcare, Evanston, IL 60201, USA
Cleve Clin J Med 75:441-8. 2008....
- [Colorectal polyps: clinical, endoscopic, and histopathologic features]S A Khder
Universitatea de Medicină si Farmacie Gr T Popa Iaşi, Facultatea de Medicina, Institutul de Gastroenterologie si Hepatologie Iaşi
Rev Med Chir Soc Med Nat Iasi 112:59-65. 2008..To evaluate the prevalence of colorectal polyps in a population from North- Eastern Romania, which underwent colonoscopic examination and to identify their clinical, endoscopic and histopathologic characteristics...
- Performance characteristics and evaluation of an automated-developed and quantitative, immunochemical, fecal occult blood screening testAlex Vilkin
Gastroenterology Department, Rabin Medical Center, Beilinson Hospital, Petach Tikva, Israel
Am J Gastroenterol 100:2519-25. 2005....
- Frequency of colorectal polyps in patients with sporadic adenomas or adenocarcinomas of the papilla of vater--an age-matched, controlled studyA R J Schneider
Medical Department I, University Hospital, Frankfurt Main, Germany
Z Gastroenterol 43:1123-7. 2005..Patients with familial adenomatous polyposis bear a particularly increased risk for periampullary tumors. Data on whether the prevalence of colorectal tumors is increased in patients with sporadic ampullary neoplasms are scarce...
- Risk of proximal colorectal neoplasia among asymptomatic patients with distal hyperplastic polypsOtto S Lin
Gastroenterology Section, Virginia Mason Medical Center, Seattle, Wash 98101, USA
Am J Med 118:1113-9. 2005..Our goal is to assess the risk of proximal neoplasia in asymptomatic patients with distal hyperplastic polyps, compared to those with distal tubular adenomas or no distal polyps...
- [Screening and surveillance for hereditary polyposis and non-polyposis syndromes with capsule endoscopy]Martá Kovács
Vaszary Kolos Kórház II Belgyógyászati Osztál, Esztergom
Orv Hetil 149:639-44. 2008..Nevertheless, determination of size and location of polyps has become more problematic when evaluating the test results...
- [Clinical, enteroscopic, and pathological characteristics of 796 cases of colorectal polyps]Fu e Li
Department of Gastroenterology, Shenzhen Hospital of Peking University, Shenzhen 518036
Zhong Nan Da Xue Xue Bao Yi Xue Ban 30:463-6. 2005..To study the age, clinical, enteroscopic and pathological characteristics of colorectal polyps and factors affected polyp-carcinoma...
- [Virtual colonoscopy--and then? Relevance of small colorectal polyps]T Rother
Klinik für Diagnostische Radiologie und Neuroradiologie, Klinikum Augsburg
Rofo 179:130-6. 2007..Growth speed lies in the range of approx. 0.4 mm in 2 years, but regression can be observed as well. The very few existing growth studies cannot provide reliable information about how quickly these small lesions may turn malignant...
- Follow-up after colorectal polypectomy: a benefit-risk analysis of German surveillance recommendationsF Becker
Department of Medical Biometry and Informatics, University of Heidelberg, 69120, Heidelberg, Germany
Int J Colorectal Dis 22:929-39. 2007..However, no benefit-risk analysis regarding to specific long-term effects of follow-up has been reported to date...
- [Colorectal polyps]Bjørn Hofstad
Gastromedisinsk avdeling, Ulleval universitetssykehus, 0407 Oslo
Tidsskr Nor Laegeforen 127:2692-5. 2007..There is circumstantial evidence that most cancers develop from polyps; so detection, eradication and follow-up stategies for polyps are important. The article provides an update on these topics...
- Comparison of malignant potential between serrated adenomas and traditional adenomasSang Yong Song
Department of Pathology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
J Gastroenterol Hepatol 22:1786-90. 2007..However, the degree of malignant potential has not been firmly established as yet. The purpose of the present paper was to compare the malignant potential and clinicopathological features between serrated and traditional adenomas...
- Risk of colorectal neoplasm in patients with acromegaly and its relationship with serum growth hormone levelsYutaka Matano
The Second Department of Internal Medicine, Kanazawa University School of Medicine, Ishikawa, Japan
Am J Gastroenterol 100:1154-60. 2005..In addition, we assessed the relationship between colorectal lesions and serum growth hormone (GH) levels in acromegalics...
- [Morphological and bio-molecular significance of colorectal serrated polyps]Fei Ye
Zhonghua Bing Li Xue Za Zhi 33:75-8. 2004
- Computed tomographic colonography or conventional colonoscopy in detecting small colonic lesions in clinical practice?Antonio Tursi
Gastroenterology 126:937-8; author reply 938-9. 2004
- The value of flexible sigmoidoscopy for patients with bright red rectal bleedingH K Choi
Department of Surgery, The University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong
Hong Kong Med J 9:171-4. 2003..To review the diagnostic yield of flexible sigmoidoscopy in patients presenting with bright red rectal bleeding...
- Superselective transcatheter embolization for acute lower gastrointestinal hemorrhage after endoscopic mucosal resection: a report of 3 casesShinichi Mezawa
Department of Gastroenterology, Tokeidai Hospital, 2 3 North 1 East 1, Chuo Ku, Sapporo 060 0031, Japan
Hepatogastroenterology 50:735-7. 2003....
- Surveillance colonoscopy following resection of colorectal polyps and cancerD K Rex
Indiana University School of Medicine, Indianapolis 46202, USA
Can J Gastroenterol 15:57-9. 2001..After the clearing colonoscopy, subsequent examinations can be performed based on the associated adenoma findings...
- Gender differences in colorectal polyps and tumorsT M McCashland
Department of Medicine, University of Nebraska Medical Center, Omaha 68198-3285, USA
Am J Gastroenterol 96:882-6. 2001..Women had a greater number of pure right-sided polyps and tumor development. Colonoscopy is needed to correctly diagnose an increasing prevalence of right-sided pathology in the elderly...
- [Long term surveillance of polyps and colorectal cancers]J Van Cauter
, C.H.U. de Charleroi, Site de Charleroi
Rev Med Brux 22:A234-7. 2001..A good follow-up by endoscopy is also necessary for patients with colorectal polyps and for patients with familial adenomatous polyposis...
- CT- and MR colonographyM P Achiam
Department of Surgical Gastroenterology, H S Hvidovre Hospital, DK 2650 Hvidovre, Denmark
Scand J Surg 91:322-7. 2002..The current diagnostic methods include sigmoidoscopy and colonoscopy. Lately, CT- and MR colonography have emerged as non-invasive methods for colon imaging...
- Immunohistochemical study of myofibroblasts in normal colonic mucosa, hyperplastic polyps, and adenomatous colorectal polypsPatrick A Adegboyega
Department of Pathology, University of Texas Medical Branch, Galveston, TX 77555, USA
Arch Pathol Lab Med 126:829-36. 2002..Through their ability to secrete cytokines, chemokines, prostaglandins, growth factors, and matrix components, they are thought to play critical roles in inflammation, growth, repair, and neoplasia...
- Virtual colonoscopy for the detection of colorectal polyps and cancers in a Chinese populationBenjamin Chun Yu Wong
Department of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong
J Gastroenterol Hepatol 17:1323-7. 2002..The aim of this study is to assess the sensitivity of virtual colonoscopy in detecting colorectal polyps and cancers in a Chinese population...
- CT colonography (virtual colonoscopy) for the detection of colorectal polyps and neoplasms. current status and future developmentsT M Gluecker
Department of Radiology, Mayo Clinic Rochester, 200 First Street S W Rochester, MN 55905, USA
Eur J Cancer 38:2070-8. 2002..Continuing technical innovations such as multidetector CT, computer-aided diagnosis, new image display techniques and faecal tagging promise to improve the performance and patient acceptance of CT colonography in the future...
- Histogenesis of human colorectal adenomas and hyperplastic polyps: the role of cell proliferation and crypt fissionW M Wong
Histopathology Unit, Imperial Cancer Research Fund, Lincoln s Inn Fields, London WC2A 3PX, UK
Gut 50:212-7. 2002..The histogenesis of human colorectal hyperplastic polyps and colorectal adenomas is poorly understood even now...
- Emerging concepts in colorectal neoplasiaJeremy R Jass
Department of Molecular and Cellular Pathology, University of Queensland Medical School, Australia
Gastroenterology 123:862-76. 2002..If colorectal cancer is a heterogeneous disease comprising discrete subsets that evolve through different pathways, it is evident that these subsets will need to be studied individually in the future...
- Concordant CpG island methylation in hyperplastic polyposisAnnie On On Chan
Department of Pathology, University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030 4095, USA
Am J Pathol 160:529-36. 2002..The hypermethylator phenotype is related to patient-specific factors, such as carcinogenic exposure or genetic predisposition...
- The case for population-based screening for colorectal cancerRobert E Schoen
Division of Gastroenterology, Pennsylvania University Hospital, Pittsburgh 15213 2582, USA
Nat Rev Cancer 2:65-70. 2002..Fuelled by new research, market opportunities and increased recognition of individual risk, screening for colorectal cancer is becoming a recommended procedure, but controversy about how best to implement widespread screening remains...
- [Endoscopic Therapy of Early Colorectal Cancer (pT1) - A Prospective Study]P Frühmorgen
Medizinische Klinik I, Schwerpunkt Gastroenterologie Hepatologie, Klinikum Ludwigsburg, Germany
Z Gastroenterol 41:703-10. 2003..In a prospective study initiated in 1982, we have been investigating the question as to whether - and if so, which - pT1 carcinomas of the colorectum can be treated exclusively via the endoscope...
- Endoscopic snare excision of large pedunculated colorectal polyps: a new, safe, and effective techniqueG Brandimarte
Dept. of Internal Medicine, Digestive Endoscopy Unit, Cristo Re Hospital, Rome, Italy
Endoscopy 33:854-7. 2001..Moreover, this technique is cheaper than the use of the standard detachable snare currently available (the cost of the snares being $50.52 compared with $189.47)...
- Approach to a colorectal polypR Muñoz Gómez
Servicio de Aparato Digestivo Hospital Universitario 12 de Octubre Madrid Spain
Rev Esp Enferm Dig 95:645-9, 640-4. 2003
- Difficult wounds: an updateRichard F Edlich
Distinguished Professor Emeritus of Plastic Surgery and Biomedical Engineering, University of Virginia Health System, Charlottesville, Virginia, USA
J Long Term Eff Med Implants 15:289-302. 2005..These cysts can be seen before the intestinal polyps are evident...
- Downregulation of prostaglandin E receptor subtype EP3 during colon cancer developmentY Shoji
Cancer Prevention Basic Research Project, National Cancer Center Research Institute, Tokyo, Japan
Gut 53:1151-8. 2004..E(2) (PGE(2)) receptors EP(1), EP(2), and EP(4) in the formation of aberrant crypt foci (ACF) and/or intestinal polyps has been suggested...
- Wireless capsule endoscopy in the pediatric age group: experience and complicationsLibia Moy
Division of Gastroenterology and Nutrition, Schneider Children s Hospital, North Shore Long Island Jewish Health System, New Hyde Park, NY 11040, USA
J Pediatr Gastroenterol Nutr 44:516-20. 2007....
- Piroxicam-induced regression of intestinal adenomatous polyps in APC(delta474) miceZ F Qiu
Second Department of Surgery, Hamamatsu University School of Medicine, Hamamatsu, Japan
J Invest Surg 16:71-81. 2003..All APC(delta474) mice have intestinal polyps. Thirty-five APC(delta474) mice were divided into three groups: 0...
- Association of multiple vertebral hemangiomas and severe paraparesis in a patient with a PTEN hamartoma tumor syndrome. Case reportBenoit Jenny
Department of Neurosurgery, University Hospitals of Geneva, Switzerland
J Neurosurg 107:307-13. 2007..Minor diagnostic criteria include hamartomatous intestinal polyps, lipomas, fibrocystic disease of the breasts, and fibromas...
- Suppression of azoxymethane-induced colon cancer development in rats by a prostaglandin E receptor EP1-selective antagonistNaoko Niho
Cancer Prevention Basic Research Project, National Cancer Center Research Institute, Chuo Ku, Tokyo 104 0045, Japan
Cancer Sci 96:260-4. 2005..ONO-8711 also reduced the numbers of intestinal polyps in Min mice...
- Involvement of prostaglandin E receptor subtype EP(4) in colon carcinogenesisMichihiro Mutoh
Cancer Prevention Division, National Cancer Center Research Institute, Tokyo 104 0045, Japan
Cancer Res 62:28-32. 2002..in the diet on the formation of AOM-induced colon ACFs in C57BL/6Cr mice and on the development of intestinal polyps in Min mice...
- Tpl2 in Intestinal TumorigenesisPhilip N Tsichlis; Fiscal Year: 2013..Contrary to expectation, Tpl2-/-/ Apcmin/+ mice exhibited a 5-fold increase in the number of intestinal polyps and a significant acceleration in tumorigenesis relative to their Tpl2+/+/Apcmin/+ littermates...
- Interaction Between SV40 Large T and p185 CullinJames A DeCaprio; Fiscal Year: 2011..Importantly, loss of Fbxw8 increases the incidence of intestinal polyps in the APCMin mouse model of cancer...
- HB-EGF's Role in Atrophic Gastritis and Gastric CancerTheodore Koh; Fiscal Year: 2002..appears to be a downstream target of the beta- catenin/Tcf-4 signaling pathway that mediates growth of intestinal polyps. Gastrin is also important in the development of the stomach...
- Preventive Role of VDR in Colorectal CarcinogenesisYan Chun Li; Fiscal Year: 2006..To test our hypothesis, we will compare the onset, number and size of intestinal polyps in APCmin/+ and APCmin/+-VDR-/- mice under regular diet, high-calcium diet and high-fat diet conditions...
- AUSTRALASIAN C0L0RECTAL CANCER FAMILY STUDYJeremy Jass; Fiscal Year: 2002..These characteristics include manageable yet sufficient size, ethnically diverse, highly localised, stable, and with families that are intact and large. ..
- Steroids and Stem Cell in CarcinogenesisDoris Benbrook; Fiscal Year: 2004..This research will enhance our understanding of the process of carcinogenesis and chemoprevention, which could ultimately translate into strategies and pharmaceuticals for prevention of cancer. ..
- Mechanism of SHeA2 Action in Ovarian CancerDoris Benbrook; Fiscal Year: 2009..The elucidation of the proteins involved in the SHetA2 pathwayswill provide potential biomarkers for ovarian cancer diagnosis, prevention and treatment strategies. ..
- Inhibition of pathogen-induced NFkBmediated inflammationRichard Peek; Fiscal Year: 2005..2)To identify and functionally characterize PPAR( target genes and microbially-induced NF-?B-regulated genes that are suppressed by PPAR(, activation using an in vitro model of intestinal epithelial cell inflammation. ..
- Regulation of SMAD4 and BMPR1A Expression in Juvenile PolyposisJames R Howe; Fiscal Year: 2010..abstract_text> ..
- Surveillance for Hepatocellular Carcinoma among HCV-infected VeteransHashem El Serag; Fiscal Year: 2009..Evaluating the extent and patterns of HCC surveillance is crucial in understanding diffusion (and obstacles) of this practice and in designing interventions to improve the implementation of HCC surveillance. ..
- Genetics of Serrated NeoplasiaJoanne Young; Fiscal Year: 2009..In this proposal, we will explore the notion that the predisposition to form hyperplastic polyps may be inherited in families. ..
- MODULATION OF COLON CARCINOGENESIS BY CHLOROPHYLLINRoderick Dashwood; Fiscal Year: 2008..3C. Determine CHL effects on beta-catenin nuclear export and Adherins junction remodeling. 3D. Assess direct effects of CHL on a downstream target of beta-catenin, c-Jun. ..
- Physical Activity Measurement in Older AdultsLisa Colbert; Fiscal Year: 2007..This methodology can then be incorporated into future studies examining the associations between doses of physical activity and various health outcomes. [unreadable] [unreadable]..
- Clinical Approaches to Ileal Pouch DysfunctionBo Shen; Fiscal Year: 2005..The AIMS of study are to 1) investigate visceral hypersensitivity using barostat examination of the pouch; 2) conduct a randomized, placebo-controlled clinical trial evaluating the use of amitriptyline in IPS. ..
- The Molecular Basis of Juvenile PolyposisJames Howe; Fiscal Year: 2005..These studies will also benefit JP patients by improving presymptomatic genetic testing, and identification of new therapeutic targets for polyp regression and cancer prevention in JP. ..
- Clinical Basis Investigations into MLS/Leopard SyndromeTheresa Pacheco; Fiscal Year: 2007..D. is an Assistant Professor of Dermatology and is committed to a career in clinical research with an focus on molecular markers of disease (pigmentation anomalies) and patient-oriented research topics. ..
- Gene Expression in Barrett's EsophagusHashem El Serag; Fiscal Year: 2006..We present preliminary data on microarray and RT-PCRanalyses on 5 patients with BE that suggest an overactive Wnt pathway: we have also assembled the essential components of a successful study using microarrays. ..
- Epidemiology of hepatocellular carcinomaCynthia Ko; Fiscal Year: 2006....
- Colonoscopy quality and outcomes in clinical practiceCynthia W Ko; Fiscal Year: 2010..The various algorithms we develop will be tested in a second, validation subset of our database to find the algorithm with optimal performance characteristics. ..
- Mechanism that regulate Helicobacter pylori-induced beta-caterin activationRichard Peek; Fiscal Year: 2009..py/ori-induced B-catenin activation. 3. To define differences in epithelial molecular responses to carcinogenic H. pylori versus mutant strains using a transgenic murine model of gastric cancer. ..
- The effect of physical activity on metabolic syndrome in pregnancy and fetal outcCynthia Ko; Fiscal Year: 2008..It may offer a safe and readily available method to control weight and improve infant health during and after pregnancy. [unreadable] [unreadable] [unreadable]..
- A Primary-Care Based Colorectal Cancer Screening ProgramCynthia Ko; Fiscal Year: 2006..If successful, this program may be useful to other large primary care practices, and may also help to improve utilization of other types of cancer prevention services ..