intestinal polyps

Summary

Summary: Discrete abnormal tissue masses that protrude into the lumen of the INTESTINE. A polyp is attached to the intestinal wall either by a stalk, pedunculus, or by a broad base.

Top Publications

  1. pmc Chemoprevention of intestinal tumorigenesis in APCmin/+ mice by silibinin
    Subapriya Rajamanickam
    Department of Pharmaceutical Sciences, School of Pharmacy and University of Colorado Cancer Center, University of Colorado Denver, Aurora, Colorado 80045, USA
    Cancer Res 70:2368-78. 2010
  2. ncbi Eicosapentaenoic acid reduces rectal polyp number and size in familial adenomatous polyposis
    Nicholas J West
    Section of Molecular Gastroenterology, Leeds Institute of Molecular Medicine, St James s University Hospital, Leeds, UK
    Gut 59:918-25. 2010
  3. ncbi Serrated and non-serrated polyps of the colorectum: their prevalence in an unselected case series and correlation of BRAF mutation analysis with the diagnosis of sessile serrated adenoma
    N J Carr
    Graduate School of Medicine, University of Wollongong, New South Wales, Australia
    J Clin Pathol 62:516-8. 2009
  4. pmc ERK activation drives intestinal tumorigenesis in Apc(min/+) mice
    Sung Hee Lee
    Department of Medicine, University of California, San Diego, La Jolla, California, USA
    Nat Med 16:665-70. 2010
  5. pmc A role for the epidermal growth factor receptor signaling in development of intestinal serrated polyps in mice and humans
    Gerold Bongers
    Immunology Institute, Mount Sinai School of Medicine, New York, New York 10029 6574, USA
    Gastroenterology 143:730-40. 2012
  6. ncbi [Contribution of coloscopy to diagnosis of rectal bleeding in Dakar (Senegal)]
    M Mbengue
    Service d Hepato Gastroenterologie, CHU Aristide Le Dantec Dakar, Senegal
    Med Trop (Mars) 69:286-8. 2009
  7. ncbi Promoter methylation of the mutated in colorectal cancer gene is a frequent early event in colorectal cancer
    M R J Kohonen-Corish
    Cancer Research Program, Garvan Institute of Medical Research, Sydney, New South Wales, Australia
    Oncogene 26:4435-41. 2007
  8. ncbi Sessile serrated adenomas: prevalence of dysplasia and carcinoma in 2139 patients
    Richard H Lash
    Caris Research Institute, Irving, Texas, USA
    J Clin Pathol 63:681-6. 2010
  9. ncbi Chemopreventive effects of dietary folate on intestinal polyps in Apc+/-Msh2-/- mice
    J Song
    Department of Nutritional Sciences, University of Toronto, Ontario, Canada
    Cancer Res 60:3191-9. 2000
  10. ncbi Sessile serrated adenoma: challenging discrimination from other serrated colonic polyps
    Alton B Farris
    Department of Pathology, Biostatistics Center, Massachusetts General Hospital, Boston, MA, USA
    Am J Surg Pathol 32:30-5. 2008

Research Grants

Detail Information

Publications228 found, 100 shown here

  1. pmc Chemoprevention of intestinal tumorigenesis in APCmin/+ mice by silibinin
    Subapriya Rajamanickam
    Department of Pharmaceutical Sciences, School of Pharmacy and University of Colorado Cancer Center, University of Colorado Denver, Aurora, Colorado 80045, USA
    Cancer Res 70:2368-78. 2010
    ..o. silibinin feeding against spontaneous intestinal tumorigenesis in the APC(min/+) mice model, suggesting its chemopreventive potential against intestinal cancers including CRC...
  2. ncbi Eicosapentaenoic acid reduces rectal polyp number and size in familial adenomatous polyposis
    Nicholas J West
    Section of Molecular Gastroenterology, Leeds Institute of Molecular Medicine, St James s University Hospital, Leeds, UK
    Gut 59:918-25. 2010
    ....
  3. ncbi Serrated and non-serrated polyps of the colorectum: their prevalence in an unselected case series and correlation of BRAF mutation analysis with the diagnosis of sessile serrated adenoma
    N J Carr
    Graduate School of Medicine, University of Wollongong, New South Wales, Australia
    J Clin Pathol 62:516-8. 2009
    ..To determine the prevalence of colorectal polyps of different types in an unselected population, and to correlate the morphological diagnoses with BRAF mutation analysis...
  4. pmc ERK activation drives intestinal tumorigenesis in Apc(min/+) mice
    Sung Hee Lee
    Department of Medicine, University of California, San Diego, La Jolla, California, USA
    Nat Med 16:665-70. 2010
    ..Our data reveal a new facet of oncogene-environment interaction, in which microflora-induced TLR activation regulates oncogene expression and related IEC tumor growth in a susceptible host...
  5. pmc A role for the epidermal growth factor receptor signaling in development of intestinal serrated polyps in mice and humans
    Gerold Bongers
    Immunology Institute, Mount Sinai School of Medicine, New York, New York 10029 6574, USA
    Gastroenterology 143:730-40. 2012
    ..Tumors that arise from these polyps frequently contain activating mutations in BRAF or KRAS, but little is known about the role of EGFR activation in their development...
  6. ncbi [Contribution of coloscopy to diagnosis of rectal bleeding in Dakar (Senegal)]
    M Mbengue
    Service d Hepato Gastroenterologie, CHU Aristide Le Dantec Dakar, Senegal
    Med Trop (Mars) 69:286-8. 2009
    ..The purpose of this report is to describe lesions discovered by coloscopy in patients assessed for rectal bleeding in Dakar, Senegal...
  7. ncbi Promoter methylation of the mutated in colorectal cancer gene is a frequent early event in colorectal cancer
    M R J Kohonen-Corish
    Cancer Research Program, Garvan Institute of Medical Research, Sydney, New South Wales, Australia
    Oncogene 26:4435-41. 2007
    ..Furthermore, MCC methylation is significantly associated with a distinct spectrum of precursor lesions, which are suggested to give rise to cancers via the serrated neoplasia pathway...
  8. ncbi Sessile serrated adenomas: prevalence of dysplasia and carcinoma in 2139 patients
    Richard H Lash
    Caris Research Institute, Irving, Texas, USA
    J Clin Pathol 63:681-6. 2010
    ..This study attempts to estimate the progression rate of SSAs based upon the epidemiology of a large cohort as well as identify relationships to other colorectal polyps...
  9. ncbi Chemopreventive effects of dietary folate on intestinal polyps in Apc+/-Msh2-/- mice
    J Song
    Department of Nutritional Sciences, University of Toronto, Ontario, Canada
    Cancer Res 60:3191-9. 2000
    ....
  10. ncbi Sessile serrated adenoma: challenging discrimination from other serrated colonic polyps
    Alton B Farris
    Department of Pathology, Biostatistics Center, Massachusetts General Hospital, Boston, MA, USA
    Am J Surg Pathol 32:30-5. 2008
    ..However, this level of variability is acceptable because the presence of SSA indicates increased risk of developing additional serrated polyps and carcinoma, and surveillance is appropriate...
  11. ncbi Molecular features of colorectal hyperplastic polyps and sessile serrated adenoma/polyps from Korea
    Kyoung Mee Kim
    Department of Pathology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea
    Am J Surg Pathol 35:1274-86. 2011
    ..left) may be a more significant risk factor of progression than the histologic type of polyp. Our data also support the theory that right-sided MVHPs may be a precursor to SSA/P...
  12. ncbi Beef induces and rye bran prevents the formation of intestinal polyps in Apc(Min) mice: relation to beta-catenin and PKC isozymes
    M Mutanen
    Department of Applied Chemistry and Microbiology Nutrition, PO Box 27, University of Helsinki, Helsinki, FIN 00014, Finland
    Carcinogenesis 21:1167-73. 2000
    ..different grain fibers as well as inulin, polydisperse beta(2-->1) fructan, could affect the formation of intestinal polyps in Apc(Min) mice...
  13. ncbi Endoscopic mucosal resection of 161 cases of large sessile or flat colorectal polyps
    Naila Arebi
    St Mark s Hospital, London, UK
    Scand J Gastroenterol 42:859-66. 2007
    ..The aim of this study was to identify the factors that may be predictive of the risk of polyp recurrence...
  14. ncbi [Lgr5 and CD44 expressions in different types of intestinal polyps and colorectal cancer]
    Ningli Chai
    Department of Gastroenterology, General Hospital of PLA, Beijing, China
    Nan Fang Yi Ke Da Xue Xue Bao 33:972-6. 2013
    To study the expression of tumorigenesis-related stem cell markers Lgr5 and CD44 in different pathological types of intestinal polyps and their clinical significance in predicting tumorigenesis.
  15. ncbi A fish oil derived concentrate enriched in eicosapentaenoic and docosahexaenoic acid as ethyl ester suppresses the formation and growth of intestinal polyps in the Min mouse
    J E Paulsen
    Department of Environmental Medicine, National Institute of Public Health, Oslo, Norway
    Carcinogenesis 18:1905-10. 1997
    ..8 +/- 0.9) and the crypt multiplicity (1.49 +/- 0.28) in females were reduced by 73% (P = 0.03) and 60% (P = 0.048) with 2.5% of K85, respectively, whereas no significant effect could be observed in the males...
  16. pmc Peroxisome proliferator-activated receptor ligand MCC-555 suppresses intestinal polyps in ApcMin/+ mice via extracellular signal-regulated kinase and peroxisome proliferator-activated receptor-dependent pathways
    Kiyoshi Yamaguchi
    Department of Pathobiology, College of Veterinary Medicine, The University of Tennessee, 2407 River Drive, Knoxville, TN 37996, USA
    Mol Cancer Ther 7:2779-87. 2008
    ..Subsequently, treatment with MCC-555 (30 mg/kg/d) for 4 weeks reduced the number of small intestinal polyps to 54.8% of that in control mice...
  17. ncbi Overexpression of low-density lipoprotein receptor and lipid accumulation in intestinal polyps in Min mice
    Michihiro Mutoh
    Cancer Prevention Basic Research Project, National Cancer Center Research Institute, Tokyo, Japan
    Int J Cancer 125:2505-10. 2009
    ..lipase (LPL), high concentration of serum triglyceride (TG), fatty change of the liver and large numbers of intestinal polyps. We have reported that induction of LPL expression reduces serum lipid, especially TG, improves fatty change ..
  18. pmc Chemoprevention of intestinal polyps in ApcMin/+ mice fed with western or balanced diets by drinking annurca apple polyphenol extract
    Lucia Fini
    Department of Internal Medicine, Baylor Research Institute, Sammons Cancer Center, USA
    Cancer Prev Res (Phila) 4:907-15. 2011
    ....
  19. ncbi Serrated polyps of the colorectum: is sessile serrated adenoma distinguishable from hyperplastic polyp in a daily practice?
    Dominique Sandmeier
    Institute of Pathology, Centre Hospitalier Universitaire Vaudois, Bugnon 25, CH 1011 Lausanne, Switzerland
    Virchows Arch 450:613-8. 2007
    ..One SSA of our series showed low-grade dysplasia supporting the concept that this lesion might be a precursor of serrated adenocarcinoma...
  20. ncbi Cancer chemoprevention of intestinal polyposis in ApcMin/+ mice by sulforaphane, a natural product derived from cruciferous vegetable
    Rong Hu
    Department of Pharmaceutics, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA
    Carcinogenesis 27:2038-46. 2006
    ....
  21. ncbi Hyperplastic polyps, serrated adenomas, and the serrated polyp neoplasia pathway
    Christopher S Huang
    Section of Gastroenterology, Boston Medical Center, Boston, Massachusetts 02118, USA
    Am J Gastroenterol 99:2242-55. 2004
  22. ncbi Serrated polyps of the large intestine: a morphologic and molecular review of an evolving concept
    Dale C Snover
    Department of Pathology, Fairview Southdale Hospital, Edina, MN 55435, USA, and McGill University, Montreal, Canada
    Am J Clin Pathol 124:380-91. 2005
    ....
  23. pmc Loss of Apc heterozygosity and abnormal tissue building in nascent intestinal polyps in mice carrying a truncated Apc gene
    M Oshima
    Banyu Tsukuba Research Institute Merck, Japan
    Proc Natl Acad Sci U S A 92:4482-6. 1995
    ..It is therefore unlikely that the truncated product interacts directly with the wild-type protein and causes the microadenomas by a dominant negative mechanism...
  24. pmc A randomised, double blind, placebo controlled study of celecoxib, a selective cyclooxygenase 2 inhibitor, on duodenal polyposis in familial adenomatous polyposis
    R K S Phillips
    Colorectal Cancer Unit, Imperial Cancer Research Fund, London, UK
    Gut 50:857-60. 2002
    ....
  25. ncbi The patient with multiple intestinal polyps
    Karsten Schulmann
    Ruhr University Bochum, Medical Department, Knappschaftskrankenhaus, Bochum, Germany
    Best Pract Res Clin Gastroenterol 21:409-26. 2007
    The management of patients with multiple intestinal polyps may be difficult and greatly depends on the correct classification. Polyposis syndromes account for less than 1% of newly diagnosed colorectal cancers...
  26. ncbi Fractal and image analysis of the microvasculature in normal intestinal submucosa and intestinal polyps in Apc(Min/+) mice
    John W Fuseler
    Department of Cell Biology and Anatomy, University of South Carolina School of Medicine, Columbia, SC 29209, USA
    Microsc Microanal 16:73-9. 2010
    ..analysis to quantify differences in the complexity of the vasculature in normal intestinal submucosa and intestinal polyps. Apc(Min/+) mice and wild-type mice were perfused with a curable latex compound, intestines sectioned, and ..
  27. ncbi Cyclooxygenase-2 expression in fibroblasts and endothelial cells of intestinal polyps
    Masahiro Sonoshita
    Department of Pharmacology, Graduate School of Medicine, Kyoto University, Kyoto 606 8501, Japan
    Cancer Res 62:6846-9. 2002
    ..By immunohistochemical analysis, here we show that the majority of COX-2-expressing cells in the intestinal polyps of Apc(Delta716) mice are fibroblasts and endothelial cells...
  28. ncbi Chemoprevention of intestinal polyposis in the Apcdelta716 mouse by rofecoxib, a specific cyclooxygenase-2 inhibitor
    M Oshima
    Tsukuba Research Institute, Banya Pharmaceutical Co, Ltd, Japan
    Cancer Res 61:1733-40. 2001
    ..Although homozygote Apc-/- mice are embryonically lethal, the heterozygotes are viable but develop numerous intestinal polyps with loss of Apc heterozygosity within the polyps (M. Oshima et al., Proc. Natl. Acad. Sci...
  29. pmc Cross-species comparison of human and mouse intestinal polyps reveals conserved mechanisms in adenomatous polyposis coli (APC)-driven tumorigenesis
    Claudia Gaspar
    Dept of Pathology, Erasmus MC, PO Box 2040, 3000CA Rotterdam, The Netherlands
    Am J Pathol 172:1363-80. 2008
    ..Here, we applied a cross-species comparison of expression profiles of intestinal polyps derived from hereditary colorectal cancer patients carrying APC germline mutations and from mice carrying a ..
  30. ncbi Cyclooxygenase 2- and prostaglandin E(2) receptor EP(2)-dependent angiogenesis in Apc(Delta716) mouse intestinal polyps
    Hiroshi Seno
    Department of Pharmacology, Kyoto University Graduate School of Medicine, Kyoto 606 8501, Japan
    Cancer Res 62:506-11. 2002
    ....
  31. pmc Efficacy, risk factors and complications of endoscopic polypectomy: ten year experience at a single center
    Pierluigi Consolo
    Department of Medicine and Pharmacology, University Hospital G Martino, Via Consolare Valeria, Messina 98100, Italy
    World J Gastroenterol 14:2364-9. 2008
    ..To examine the efficacy and complications of colonoscopic resection of colorectal polypoid lesions...
  32. ncbi Occult colorectal polyps on CT colonography: implications for surveillance
    Robert L MacCarty
    Mayo Clinic, Mayo Medical School, Mary Clinic E 2, 200 First St SW, Rochester, MN 55905, USA
    AJR Am J Roentgenol 186:1380-3. 2006
    ..Differences in the prevalence of occult polyps in various populations might help explain the discordant reported sensitivities for polyp detection in published reports of CTC...
  33. ncbi Suppression of intestinal polyps in Msh2-deficient and non-Msh2-deficient multiple intestinal neoplasia mice by a specific cyclooxygenase-2 inhibitor and by a dual cyclooxygenase-1/2 inhibitor
    G Lal
    Centre for Cancer Genetics, Samuel Lunenfeld Research Institute, Department of Surgery, Mount Sinai Hospital, University of Toronto, Toronto, Ontario, M5G 1X5 Canada
    Cancer Res 61:6131-6. 2001
    ..overexpressed in adenomas and colorectal cancers, and COX-2-specific inhibitors have been shown to inhibit intestinal polyps in Apc(Delta716) mice more effectively than dual COX-1/COX-2 inhibitors such as sulindac...
  34. ncbi Pharmacogenomics of cancer chemopreventive isothiocyanate compound sulforaphane in the intestinal polyps of ApcMin/+ mice
    Tin Oo Khor
    Department of Pharmaceutics, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA
    Biopharm Drug Dispos 27:407-20. 2006
    ..Recently it was found that SFN could also suppress the growth of intestinal polyps in the ApcMin/+ mouse...
  35. ncbi CT colonography at different radiation dose levels: feasibility of dose reduction
    Rogier E van Gelder
    Department of Radiology, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Radiology 224:25-33. 2002
    ..To investigate the sensitivity and specificity of polyp detection and the image quality of computed tomographic (CT) colonography at different radiation dose levels and to study effective doses reported in literature on CT colonography...
  36. pmc Wireless capsule endoscopy in detecting small-intestinal polyps in familial adenomatous polyposis
    Panagiotis Katsinelos
    Department of Endoscopy and Motility Unit, Central Hospital, Ethnikis Aminis 41, 54635, Thessaloniki, Greece
    World J Gastroenterol 15:6075-9. 2009
    ..To detect the prevalence of small bowel polyps by wireless capsule endoscopy (WCE) in patients with familial adenomatous polyposis (FAP)...
  37. ncbi The role of cyclooxygenase-2 (COX-2) in two different morphological stages of intestinal polyps in APC(Delta474) knockout mice
    Ken ichi Sunayama
    2nd Department of Surgery, Hamamatsu University School of Medicine, 1 20 1 Handayama, Hamamatsu, 431 3192, Japan
    Carcinogenesis 23:1351-9. 2002
    ....
  38. ncbi Sessile serrated adenoma (SSA) vs. traditional serrated adenoma (TSA)
    Emina Emilia Torlakovic
    Department of Pathology, Royal University Hospital, University of Saskatchewan, Saskatoon, SK, Canada
    Am J Surg Pathol 32:21-9. 2008
    ....
  39. pmc Conventional colonoscopy and magnified chromoendoscopy for the endoscopic histological prediction of diminutive colorectal polyps: a single operator study
    Giovanni D De Palma
    DUN Chirurgia Generale e Tecnologie Avanzate, AOU Federico II, Facolta di Medicina e Chirurgia, Via Pansini, 5, 80131 Napoli, Italy
    World J Gastroenterol 12:2402-5. 2006
    ..To accurately differentiate the adenomatous from the non-adenomatous polyps by colonoscopy...
  40. ncbi Consider colonoscopy for young patients with hematochezia
    Robert F Wong
    Division of Gastroenterology, 4R 118 SOM, University of Utah Medical Center, 50 North Medical Drive, Salt Lake City, UT 84132, USA
    J Fam Pract 53:879-84. 2004
    ..Hematochezia is a common complaint in adult patients aged <50 years. Most studies of lower endoscopy for rectal bleeding have concentrated on older patients or have failed to mention the location of lesions...
  41. ncbi [Endoscopic treatment of colorectal polyps in a digestive endoscopy outpatient department]
    Giorgio Romano
    Divisione di Chirurgia Generale, dell Uremico e dei Trapianti d Organo, Facolta di Medicina e Chirurgia, Universita degli Studi di Palermo
    Chir Ital 56:669-73. 2004
    ..We therefore conclude that colonoscopy allows not only early diagnosis of colonic neoplasms, but also radical curative treatment in the early stages...
  42. ncbi An unusual complication: postcolonoscopy appendicitis
    R Pellish
    Department of Medicine, Division of Gastroenterology, Brown Medical School, Rhode Island Hospital, Providence, Rhode Island, USA
    Endoscopy 39:E138. 2007
  43. ncbi Six-year prospective analysis of the rectal bleeding clinic at the Queen Elizabeth Hospital, Adelaide, South Australia
    Jen S J Lee
    Colorectal Unit, Division of Surgery, The University of Adelaide Discipline of Surgery, The Queen Elizabeth Hospital, Woodville, South Australia, Australia
    ANZ J Surg 77:553-6. 2007
    ..The Queen Elizabeth Hospital RBC is an open access clinic and is unique in South Australia. It offers flexible sigmoidoscopy and facilities for treating common anorectal conditions...
  44. ncbi Is endoscopic polypectomy an adequate therapy for malignant colorectal adenomas? Presentation of 114 patients and review of the literature
    U Seitz
    Interdisciplinary Endoscopy, University Hospital Eppendorf, Hamburg, Germany
    Dis Colon Rectum 47:1789-96; discussion 1796-7. 2004
    ..This study was designed to evaluate the outcome of endoscopic polypectomy of malignant polyps with and without subsequent surgery based on histologic criteria...
  45. ncbi Magnifying chromoendoscopy: effective diagnostic tool for screening colonoscopy
    Ralf Kiesslich
    J Gastroenterol Hepatol 22:1700-1. 2007
  46. ncbi Further validation of magnifying chromocolonoscopy for differentiating colorectal neoplastic polyps in a health screening center
    Fabian Emura
    Division of Endoscopy, National Cancer Center Hospital, Tokyo, Japan
    J Gastroenterol Hepatol 22:1722-7. 2007
    ..This study aimed to further validate the effectiveness of magnifying chromocolonoscopy in the diagnosis of neoplastic colorectal polyps in a screening center...
  47. ncbi Detachable snare versus epinephrine injection in the prevention of postpolypectomy bleeding: a randomized and controlled study
    P Di Giorgio
    Gastrointestinal Endoscopy Unit, Pellegrini Hospital, Naples, Italy
    Endoscopy 36:860-3. 2004
    ..Several endoscopic techniques have been developed to prevent bleeding after the removal of large pedunculated polyps...
  48. ncbi Endoloop-assisted polypectomy for large pedunculated colorectal polyps
    P Katsinelos
    Department of Endoscopy and Motility Unit, Central Hospital, Ethnikis Aminis 41, 546 35, Thessaloniki, Greece
    Surg Endosc 20:1257-61. 2006
    ....
  49. ncbi Colonoscopy: as good as gold?
    David Lieberman
    Ann Intern Med 141:401-3. 2004
  50. ncbi Location of adenomas missed by optical colonoscopy
    Perry J Pickhardt
    Department of Radiology, University of Wisconsin Medical School, E3 311 Clinical Science Center, 600 Highland Avenue, Madison, WI 53792 3252, USA
    Ann Intern Med 141:352-9. 2004
    ..Previous estimates of the adenoma miss rate with optical colonoscopy (OC) are hindered by the use of OC as its own reference standard...
  51. ncbi EMR of large sessile colorectal polyps
    Massimo Conio
    Department of Gastroenterology, National Institute for Cancer Research, Via Trento 42 14, 16145 Genoa, Italy
    Gastrointest Endosc 60:234-41. 2004
    ..EMR optimizes histopathologic assessment of resected lesions. This study evaluated the outcome of EMR of large sessile colorectal polyps in terms of complications and recurrence...
  52. ncbi Detection of colorectal polyps by multislice CT colonography with ultra-low-dose technique: comparison with high-resolution videocolonoscopy
    Christoph Vogt
    Division of Medicine, Department of Gastroenterology, Hepatology and Infectious Diseases, Institute of Diagnostic Radiology, Heinrich Heine University of Dusseldorf, Moorenstrasse 5, D 40225 Dusseldorf, Germany
    Gastrointest Endosc 60:201-9. 2004
    ..This prospective study compared multislice CT colonography with ultra-low-dose technique to high-resolution videocolonoscopy as the standard for detection of colorectal cancer and polyps...
  53. ncbi Utility of MIB-1 (Ki-67) in evaluating diminutive colorectal polyps with cautery artifact
    Gabriel M Groisman
    Department of Pathology, Hillel Yaffe Medical Center, Hadera 38100, Israel
    Arch Pathol Lab Med 131:1089-93. 2007
    ..However, interpretation of diminutive colorectal polyps removed by thermal electrocoagulation (hot biopsy technique) is often problematic as a result of cautery artifact...
  54. ncbi Colorectal polypectomy and risk of colorectal cancer by subsite: the Fukuoka Colorectal Cancer study
    Daigo Yoshida
    Department of Preventive Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Jpn J Clin Oncol 37:597-602. 2007
    ..However, benefit of colorectal polypectomy in routine practice is still uncertain. We therefore investigated subsite-specific risks of colorectal cancer in relation to history of colorectal polypectomy in a case-control study...
  55. ncbi An evaluation of colorectal endoscopic mucosal resection using high-magnification chromoscopic colonoscopy: a prospective study of 1000 colonoscopies
    D P Hurlstone
    Gastroenterology and Liver Unit, Royal Hallamshire Hospital, Sheffield, United Kingdom
    Endoscopy 36:491-8. 2004
    ..The aim of the present study was to assess the efficacy and safety of en-bloc endoscopic mucosal resection with high-magnification chromoendoscopy in the management of sessile and flat colorectal lesions </= 20 mm...
  56. ncbi Safety and efficacy of argon plasma coagulator ablation therapy for flat colorectal adenomas
    A Garcia
    Unit of Gastrointestinal Endoscopy, Department of Digestive Diseases, Hospital Gregorio Maranon, Madrid, Spain
    Rev Esp Enferm Dig 96:315-21. 2004
    ..argon-plasma coagulation (APC) has been used safely and efficaciously in multiple settings including colon polyp treatment. The aim of this study was to evaluate APC efficacy and safety in the treatment of flat colorectal adenomas...
  57. ncbi Do serrated adenomas have higher malignant potential than traditional adenomas?
    Bing Zou
    J Gastroenterol Hepatol 22:1701-3. 2007
  58. ncbi [Colorectal polyps and colorectal cancer]
    Jie Zheng
    Zhonghua Bing Li Xue Za Zhi 34:4-5. 2005
  59. ncbi Low rate of microsatellite instability in young patients with adenomas: reassessing the Bethesda guidelines
    Fernando S Velayos
    Division of Gastroenterology and Colorectal Cancer Prevention Program, University of California, San Francisco, CA, USA
    Am J Gastroenterol 100:1143-9. 2005
    ..We sought to determine the rate of MSI in adenomas removed from individuals under 40 yr of age over a 5-yr period in a university general gastroenterology practice...
  60. ncbi The usefulness of colonoscopy as a screening test for detecting colorectal polyps
    Dae Han Kim
    Division of Gastroenterology, Department of Internal Medicine Korea Institute of Radiological and Medical Sciences, Seoul, Korea
    Hepatogastroenterology 54:2240-2. 2007
    ..Colonic polyps are the most common lesions encountered during screening colonoscopy. The purpose of this study is to evaluate the usefulness of colonoscopy to detect colonic polyps in adults...
  61. ncbi [Effectiveness of screening colonoscopy in a community-based study]
    D Hüppe
    Gastroenterologische Gemeinschaftspraxis Herne, Herne
    Z Gastroenterol 46:193-200. 2008
    ..Screening colonoscopy detects colorectal cancers in the early stages. Given the favourable prognosis in these stages, screening can reduce CRC-related mortality...
  62. ncbi Endoscopic mucosal resection (EMR) in the management of large colo-rectal polyps
    J K A Jameel
    Academic Surgical Unit, University of Hull, Hull, UK
    Colorectal Dis 8:497-500. 2006
    ..Endoscopic Mucosal Resection (EMR) may significantly reduce this risk. We aim to assess the safety and efficacy of EMR in our unit...
  63. ncbi [Distal hyperplastic polyps as a marker for advanced neoplasm of the proximal colon. Our experience]
    M Zippi
    Struttura Complessa di Gastroenterologia ed Endoscopia Digestiva, Ospedale Sandro Pertini, Roma, Italia
    Clin Ter 158:421-4. 2007
    ..The aim of this study was to investigate, retrospectively, the possible correlation between the distal hyperplastic polyps and proximal colorectal neoplasia...
  64. ncbi Update on colorectal cancer imaging
    Marc J Gollub
    Department of Radiology, Weill Medical College of Cornell University, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Radiol Clin North Am 45:85-118. 2007
    ..Staging with CT, MR imaging, endorectal ultrasound, and positron emission tomography are of paramount importance in determining the most appropriate therapy and the risk of tumor recurrence and overall prognosis...
  65. ncbi Understanding current guidelines for colorectal cancer screening: a case-based approach
    Laura K Bianchi
    Division of Gastroenterology, Evanston Northwestern Healthcare, Evanston, IL 60201, USA
    Cleve Clin J Med 75:441-8. 2008
    ....
  66. ncbi [Colorectal polyps: clinical, endoscopic, and histopathologic features]
    S A Khder
    Universitatea de Medicină si Farmacie Gr T Popa Iaşi, Facultatea de Medicina, Institutul de Gastroenterologie si Hepatologie Iaşi
    Rev Med Chir Soc Med Nat Iasi 112:59-65. 2008
    ..To evaluate the prevalence of colorectal polyps in a population from North- Eastern Romania, which underwent colonoscopic examination and to identify their clinical, endoscopic and histopathologic characteristics...
  67. ncbi Performance characteristics and evaluation of an automated-developed and quantitative, immunochemical, fecal occult blood screening test
    Alex Vilkin
    Gastroenterology Department, Rabin Medical Center, Beilinson Hospital, Petach Tikva, Israel
    Am J Gastroenterol 100:2519-25. 2005
    ....
  68. ncbi Frequency of colorectal polyps in patients with sporadic adenomas or adenocarcinomas of the papilla of vater--an age-matched, controlled study
    A R J Schneider
    Medical Department I, University Hospital, Frankfurt Main, Germany
    Z Gastroenterol 43:1123-7. 2005
    ..Patients with familial adenomatous polyposis bear a particularly increased risk for periampullary tumors. Data on whether the prevalence of colorectal tumors is increased in patients with sporadic ampullary neoplasms are scarce...
  69. ncbi Risk of proximal colorectal neoplasia among asymptomatic patients with distal hyperplastic polyps
    Otto S Lin
    Gastroenterology Section, Virginia Mason Medical Center, Seattle, Wash 98101, USA
    Am J Med 118:1113-9. 2005
    ..Our goal is to assess the risk of proximal neoplasia in asymptomatic patients with distal hyperplastic polyps, compared to those with distal tubular adenomas or no distal polyps...
  70. ncbi [Screening and surveillance for hereditary polyposis and non-polyposis syndromes with capsule endoscopy]
    Martá Kovács
    Vaszary Kolos Kórház II Belgyógyászati Osztál, Esztergom
    Orv Hetil 149:639-44. 2008
    ..Nevertheless, determination of size and location of polyps has become more problematic when evaluating the test results...
  71. ncbi [Clinical, enteroscopic, and pathological characteristics of 796 cases of colorectal polyps]
    Fu e Li
    Department of Gastroenterology, Shenzhen Hospital of Peking University, Shenzhen 518036
    Zhong Nan Da Xue Xue Bao Yi Xue Ban 30:463-6. 2005
    ..To study the age, clinical, enteroscopic and pathological characteristics of colorectal polyps and factors affected polyp-carcinoma...
  72. ncbi [Virtual colonoscopy--and then? Relevance of small colorectal polyps]
    T Rother
    Klinik für Diagnostische Radiologie und Neuroradiologie, Klinikum Augsburg
    Rofo 179:130-6. 2007
    ..Growth speed lies in the range of approx. 0.4 mm in 2 years, but regression can be observed as well. The very few existing growth studies cannot provide reliable information about how quickly these small lesions may turn malignant...
  73. ncbi Follow-up after colorectal polypectomy: a benefit-risk analysis of German surveillance recommendations
    F Becker
    Department of Medical Biometry and Informatics, University of Heidelberg, 69120, Heidelberg, Germany
    Int J Colorectal Dis 22:929-39. 2007
    ..However, no benefit-risk analysis regarding to specific long-term effects of follow-up has been reported to date...
  74. ncbi [Colorectal polyps]
    Bjørn Hofstad
    Gastromedisinsk avdeling, Ulleval universitetssykehus, 0407 Oslo
    Tidsskr Nor Laegeforen 127:2692-5. 2007
    ..There is circumstantial evidence that most cancers develop from polyps; so detection, eradication and follow-up stategies for polyps are important. The article provides an update on these topics...
  75. ncbi Comparison of malignant potential between serrated adenomas and traditional adenomas
    Sang Yong Song
    Department of Pathology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
    J Gastroenterol Hepatol 22:1786-90. 2007
    ..However, the degree of malignant potential has not been firmly established as yet. The purpose of the present paper was to compare the malignant potential and clinicopathological features between serrated and traditional adenomas...
  76. ncbi Risk of colorectal neoplasm in patients with acromegaly and its relationship with serum growth hormone levels
    Yutaka Matano
    The Second Department of Internal Medicine, Kanazawa University School of Medicine, Ishikawa, Japan
    Am J Gastroenterol 100:1154-60. 2005
    ..In addition, we assessed the relationship between colorectal lesions and serum growth hormone (GH) levels in acromegalics...
  77. ncbi [Morphological and bio-molecular significance of colorectal serrated polyps]
    Fei Ye
    Zhonghua Bing Li Xue Za Zhi 33:75-8. 2004
  78. ncbi Computed tomographic colonography or conventional colonoscopy in detecting small colonic lesions in clinical practice?
    Antonio Tursi
    Gastroenterology 126:937-8; author reply 938-9. 2004
  79. ncbi The value of flexible sigmoidoscopy for patients with bright red rectal bleeding
    H K Choi
    Department of Surgery, The University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong
    Hong Kong Med J 9:171-4. 2003
    ..To review the diagnostic yield of flexible sigmoidoscopy in patients presenting with bright red rectal bleeding...
  80. ncbi Superselective transcatheter embolization for acute lower gastrointestinal hemorrhage after endoscopic mucosal resection: a report of 3 cases
    Shinichi Mezawa
    Department of Gastroenterology, Tokeidai Hospital, 2 3 North 1 East 1, Chuo Ku, Sapporo 060 0031, Japan
    Hepatogastroenterology 50:735-7. 2003
    ....
  81. ncbi Surveillance colonoscopy following resection of colorectal polyps and cancer
    D K Rex
    Indiana University School of Medicine, Indianapolis 46202, USA
    Can J Gastroenterol 15:57-9. 2001
    ..After the clearing colonoscopy, subsequent examinations can be performed based on the associated adenoma findings...
  82. ncbi Gender differences in colorectal polyps and tumors
    T M McCashland
    Department of Medicine, University of Nebraska Medical Center, Omaha 68198-3285, USA
    Am J Gastroenterol 96:882-6. 2001
    ..Women had a greater number of pure right-sided polyps and tumor development. Colonoscopy is needed to correctly diagnose an increasing prevalence of right-sided pathology in the elderly...
  83. ncbi [Long term surveillance of polyps and colorectal cancers]
    J Van Cauter
    , C.H.U. de Charleroi, Site de Charleroi
    Rev Med Brux 22:A234-7. 2001
    ..A good follow-up by endoscopy is also necessary for patients with colorectal polyps and for patients with familial adenomatous polyposis...
  84. ncbi CT- and MR colonography
    M P Achiam
    Department of Surgical Gastroenterology, H S Hvidovre Hospital, DK 2650 Hvidovre, Denmark
    Scand J Surg 91:322-7. 2002
    ..The current diagnostic methods include sigmoidoscopy and colonoscopy. Lately, CT- and MR colonography have emerged as non-invasive methods for colon imaging...
  85. ncbi Immunohistochemical study of myofibroblasts in normal colonic mucosa, hyperplastic polyps, and adenomatous colorectal polyps
    Patrick A Adegboyega
    Department of Pathology, University of Texas Medical Branch, Galveston, TX 77555, USA
    Arch Pathol Lab Med 126:829-36. 2002
    ..Through their ability to secrete cytokines, chemokines, prostaglandins, growth factors, and matrix components, they are thought to play critical roles in inflammation, growth, repair, and neoplasia...
  86. ncbi Virtual colonoscopy for the detection of colorectal polyps and cancers in a Chinese population
    Benjamin Chun Yu Wong
    Department of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong
    J Gastroenterol Hepatol 17:1323-7. 2002
    ..The aim of this study is to assess the sensitivity of virtual colonoscopy in detecting colorectal polyps and cancers in a Chinese population...
  87. ncbi CT colonography (virtual colonoscopy) for the detection of colorectal polyps and neoplasms. current status and future developments
    T M Gluecker
    Department of Radiology, Mayo Clinic Rochester, 200 First Street S W Rochester, MN 55905, USA
    Eur J Cancer 38:2070-8. 2002
    ..Continuing technical innovations such as multidetector CT, computer-aided diagnosis, new image display techniques and faecal tagging promise to improve the performance and patient acceptance of CT colonography in the future...
  88. pmc Histogenesis of human colorectal adenomas and hyperplastic polyps: the role of cell proliferation and crypt fission
    W M Wong
    Histopathology Unit, Imperial Cancer Research Fund, Lincoln s Inn Fields, London WC2A 3PX, UK
    Gut 50:212-7. 2002
    ..The histogenesis of human colorectal hyperplastic polyps and colorectal adenomas is poorly understood even now...
  89. ncbi Emerging concepts in colorectal neoplasia
    Jeremy R Jass
    Department of Molecular and Cellular Pathology, University of Queensland Medical School, Australia
    Gastroenterology 123:862-76. 2002
    ..If colorectal cancer is a heterogeneous disease comprising discrete subsets that evolve through different pathways, it is evident that these subsets will need to be studied individually in the future...
  90. pmc Concordant CpG island methylation in hyperplastic polyposis
    Annie On On Chan
    Department of Pathology, University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030 4095, USA
    Am J Pathol 160:529-36. 2002
    ..The hypermethylator phenotype is related to patient-specific factors, such as carcinogenic exposure or genetic predisposition...
  91. ncbi The case for population-based screening for colorectal cancer
    Robert E Schoen
    Division of Gastroenterology, Pennsylvania University Hospital, Pittsburgh 15213 2582, USA
    Nat Rev Cancer 2:65-70. 2002
    ..Fuelled by new research, market opportunities and increased recognition of individual risk, screening for colorectal cancer is becoming a recommended procedure, but controversy about how best to implement widespread screening remains...
  92. ncbi [Endoscopic Therapy of Early Colorectal Cancer (pT1) - A Prospective Study]
    P Frühmorgen
    Medizinische Klinik I, Schwerpunkt Gastroenterologie Hepatologie, Klinikum Ludwigsburg, Germany
    Z Gastroenterol 41:703-10. 2003
    ..In a prospective study initiated in 1982, we have been investigating the question as to whether - and if so, which - pT1 carcinomas of the colorectum can be treated exclusively via the endoscope...
  93. ncbi Endoscopic snare excision of large pedunculated colorectal polyps: a new, safe, and effective technique
    G Brandimarte
    Dept. of Internal Medicine, Digestive Endoscopy Unit, Cristo Re Hospital, Rome, Italy
    Endoscopy 33:854-7. 2001
    ..Moreover, this technique is cheaper than the use of the standard detachable snare currently available (the cost of the snares being $50.52 compared with $189.47)...
  94. ncbi Approach to a colorectal polyp
    R Muñoz Gómez
    Servicio de Aparato Digestivo Hospital Universitario 12 de Octubre Madrid Spain
    Rev Esp Enferm Dig 95:645-9, 640-4. 2003
  95. ncbi Difficult wounds: an update
    Richard F Edlich
    Distinguished Professor Emeritus of Plastic Surgery and Biomedical Engineering, University of Virginia Health System, Charlottesville, Virginia, USA
    J Long Term Eff Med Implants 15:289-302. 2005
    ..These cysts can be seen before the intestinal polyps are evident...
  96. pmc Downregulation of prostaglandin E receptor subtype EP3 during colon cancer development
    Y Shoji
    Cancer Prevention Basic Research Project, National Cancer Center Research Institute, Tokyo, Japan
    Gut 53:1151-8. 2004
    ..E(2) (PGE(2)) receptors EP(1), EP(2), and EP(4) in the formation of aberrant crypt foci (ACF) and/or intestinal polyps has been suggested...
  97. ncbi Wireless capsule endoscopy in the pediatric age group: experience and complications
    Libia Moy
    Division of Gastroenterology and Nutrition, Schneider Children s Hospital, North Shore Long Island Jewish Health System, New Hyde Park, NY 11040, USA
    J Pediatr Gastroenterol Nutr 44:516-20. 2007
    ....
  98. ncbi Piroxicam-induced regression of intestinal adenomatous polyps in APC(delta474) mice
    Z F Qiu
    Second Department of Surgery, Hamamatsu University School of Medicine, Hamamatsu, Japan
    J Invest Surg 16:71-81. 2003
    ..All APC(delta474) mice have intestinal polyps. Thirty-five APC(delta474) mice were divided into three groups: 0...
  99. ncbi Association of multiple vertebral hemangiomas and severe paraparesis in a patient with a PTEN hamartoma tumor syndrome. Case report
    Benoit Jenny
    Department of Neurosurgery, University Hospitals of Geneva, Switzerland
    J Neurosurg 107:307-13. 2007
    ..Minor diagnostic criteria include hamartomatous intestinal polyps, lipomas, fibrocystic disease of the breasts, and fibromas...
  100. ncbi Suppression of azoxymethane-induced colon cancer development in rats by a prostaglandin E receptor EP1-selective antagonist
    Naoko Niho
    Cancer Prevention Basic Research Project, National Cancer Center Research Institute, Chuo Ku, Tokyo 104 0045, Japan
    Cancer Sci 96:260-4. 2005
    ..ONO-8711 also reduced the numbers of intestinal polyps in Min mice...
  101. ncbi Involvement of prostaglandin E receptor subtype EP(4) in colon carcinogenesis
    Michihiro Mutoh
    Cancer Prevention Division, National Cancer Center Research Institute, Tokyo 104 0045, Japan
    Cancer Res 62:28-32. 2002
    ..in the diet on the formation of AOM-induced colon ACFs in C57BL/6Cr mice and on the development of intestinal polyps in Min mice...

Research Grants24

  1. Tpl2 in Intestinal Tumorigenesis
    Philip N Tsichlis; Fiscal Year: 2013
    ..Contrary to expectation, Tpl2-/-/ Apcmin/+ mice exhibited a 5-fold increase in the number of intestinal polyps and a significant acceleration in tumorigenesis relative to their Tpl2+/+/Apcmin/+ littermates...
  2. Interaction Between SV40 Large T and p185 Cullin
    James A DeCaprio; Fiscal Year: 2011
    ..Importantly, loss of Fbxw8 increases the incidence of intestinal polyps in the APCMin mouse model of cancer...
  3. HB-EGF's Role in Atrophic Gastritis and Gastric Cancer
    Theodore Koh; Fiscal Year: 2002
    ..appears to be a downstream target of the beta- catenin/Tcf-4 signaling pathway that mediates growth of intestinal polyps. Gastrin is also important in the development of the stomach...
  4. Preventive Role of VDR in Colorectal Carcinogenesis
    Yan Chun Li; Fiscal Year: 2006
    ..To test our hypothesis, we will compare the onset, number and size of intestinal polyps in APCmin/+ and APCmin/+-VDR-/- mice under regular diet, high-calcium diet and high-fat diet conditions...
  5. AUSTRALASIAN C0L0RECTAL CANCER FAMILY STUDY
    Jeremy Jass; Fiscal Year: 2002
    ..These characteristics include manageable yet sufficient size, ethnically diverse, highly localised, stable, and with families that are intact and large. ..
  6. Steroids and Stem Cell in Carcinogenesis
    Doris Benbrook; Fiscal Year: 2004
    ..This research will enhance our understanding of the process of carcinogenesis and chemoprevention, which could ultimately translate into strategies and pharmaceuticals for prevention of cancer. ..
  7. Mechanism of SHeA2 Action in Ovarian Cancer
    Doris Benbrook; Fiscal Year: 2009
    ..The elucidation of the proteins involved in the SHetA2 pathwayswill provide potential biomarkers for ovarian cancer diagnosis, prevention and treatment strategies. ..
  8. Inhibition of pathogen-induced NFkBmediated inflammation
    Richard Peek; Fiscal Year: 2005
    ..2)To identify and functionally characterize PPAR( target genes and microbially-induced NF-?B-regulated genes that are suppressed by PPAR(, activation using an in vitro model of intestinal epithelial cell inflammation. ..
  9. Regulation of SMAD4 and BMPR1A Expression in Juvenile Polyposis
    James R Howe; Fiscal Year: 2010
    ..abstract_text> ..
  10. Surveillance for Hepatocellular Carcinoma among HCV-infected Veterans
    Hashem El Serag; Fiscal Year: 2009
    ..Evaluating the extent and patterns of HCC surveillance is crucial in understanding diffusion (and obstacles) of this practice and in designing interventions to improve the implementation of HCC surveillance. ..
  11. Genetics of Serrated Neoplasia
    Joanne Young; Fiscal Year: 2009
    ..In this proposal, we will explore the notion that the predisposition to form hyperplastic polyps may be inherited in families. ..
  12. MODULATION OF COLON CARCINOGENESIS BY CHLOROPHYLLIN
    Roderick Dashwood; Fiscal Year: 2008
    ..3C. Determine CHL effects on beta-catenin nuclear export and Adherins junction remodeling. 3D. Assess direct effects of CHL on a downstream target of beta-catenin, c-Jun. ..
  13. Physical Activity Measurement in Older Adults
    Lisa Colbert; Fiscal Year: 2007
    ..This methodology can then be incorporated into future studies examining the associations between doses of physical activity and various health outcomes. [unreadable] [unreadable]..
  14. Clinical Approaches to Ileal Pouch Dysfunction
    Bo Shen; Fiscal Year: 2005
    ..The AIMS of study are to 1) investigate visceral hypersensitivity using barostat examination of the pouch; 2) conduct a randomized, placebo-controlled clinical trial evaluating the use of amitriptyline in IPS. ..
  15. The Molecular Basis of Juvenile Polyposis
    James Howe; Fiscal Year: 2005
    ..These studies will also benefit JP patients by improving presymptomatic genetic testing, and identification of new therapeutic targets for polyp regression and cancer prevention in JP. ..
  16. Clinical Basis Investigations into MLS/Leopard Syndrome
    Theresa Pacheco; Fiscal Year: 2007
    ..D. is an Assistant Professor of Dermatology and is committed to a career in clinical research with an focus on molecular markers of disease (pigmentation anomalies) and patient-oriented research topics. ..
  17. Gene Expression in Barrett's Esophagus
    Hashem El Serag; Fiscal Year: 2006
    ..We present preliminary data on microarray and RT-PCRanalyses on 5 patients with BE that suggest an overactive Wnt pathway: we have also assembled the essential components of a successful study using microarrays. ..
  18. Epidemiology of hepatocellular carcinoma
    Cynthia Ko; Fiscal Year: 2006
    ....
  19. Colonoscopy quality and outcomes in clinical practice
    Cynthia W Ko; Fiscal Year: 2010
    ..The various algorithms we develop will be tested in a second, validation subset of our database to find the algorithm with optimal performance characteristics. ..
  20. Mechanism that regulate Helicobacter pylori-induced beta-caterin activation
    Richard Peek; Fiscal Year: 2009
    ..py/ori-induced B-catenin activation. 3. To define differences in epithelial molecular responses to carcinogenic H. pylori versus mutant strains using a transgenic murine model of gastric cancer. ..
  21. The effect of physical activity on metabolic syndrome in pregnancy and fetal outc
    Cynthia Ko; Fiscal Year: 2008
    ..It may offer a safe and readily available method to control weight and improve infant health during and after pregnancy. [unreadable] [unreadable] [unreadable]..
  22. A Primary-Care Based Colorectal Cancer Screening Program
    Cynthia Ko; Fiscal Year: 2006
    ..If successful, this program may be useful to other large primary care practices, and may also help to improve utilization of other types of cancer prevention services ..