Genomes and Genes
Summary: Enlargement of the spleen.
Publications276 found, 100 shown here
- Anemia and splenomegaly in cGKI-deficient miceMichael Foller
Department of Physiology, Interfakultäres Institut für Biochemie, University of Tubingen, D72076 Tübingen, Germany
Proc Natl Acad Sci U S A 105:6771-6. 2008..By the age of 10 weeks, cGKI-deficient mice exhibited pronounced anemia and splenomegaly. Compared with control mice, the cGKI mutants had significantly lower red blood cell count, packed cell volume, ..
- Silencing of microRNA-21 in vivo ameliorates autoimmune splenomegaly in lupus miceBarry G Garchow
Division of Rheumatology, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, USA
EMBO Mol Med 3:605-15. 2011..B and T cells is up-regulated and that in vivo silencing of miR-21 using a tiny seed-targeting LNA reversed splenomegaly, one of the cardinal manifestations of autoimmunity in B6...
- Hyperreactive malarial splenomegaly in expatriatesRanjan K Singh
District Hospital Daltonganj, Jharkhand, India
Travel Med Infect Dis 5:24-9. 2007Hyperreactive malarial splenomegaly, one of the major causes of splenomegaly in tropics, has been often reported in expatriates of non-tropical settings...
- Relevance of the mTOR signaling pathway in the pathophysiology of splenomegaly in rats with chronic portal hypertensionMarc Mejias
Liver Unit, Institute of Biomedical Research IDIBAPS, CIBERehd, Hospital Clinic, University of Barcelona, Villarroel 170, Barcelona, Spain
J Hepatol 52:529-39. 2010b>Splenomegaly is a frequent hallmark of portal hypertension that, in some cases, can be very prominent and cause symptoms like abdominal pain, splenic infarction, and cytopenia...
- How I treat symptomatic splenomegaly in patients with myelofibrosisRuben A Mesa
Division of Hematology Oncology, Mayo Clinic Arizona, Scottsdale, AZ 85259, USA
Blood 113:5394-400. 2009..MF patients have a range of debilitating disease manifestations (eg, massive splenomegaly, cytopenias, constitutional symptoms, and transformation to a treatment-refractory blast phase)...
- Haematological and biochemistry laboratory abnormalities associated with splenomegaly in asymptomatic adults in Masaka, Uganda: implications for HIV biomedical prevention trialsEugene Ruzagira
Medical Research Council Uganda Virus Research Institute Uganda Research Unit on AIDS, Entebbe, Uganda
Trop Med Int Health 15:105-12. 2010To assess the degree of haematological and biochemistry abnormalities associated with splenomegaly in asymptomatic adults in order to determine whether they may be eligible for inclusion in HIV biomedical prevention trials.
- Determination of splenomegaly by CT: is there a place for a single measurement?Alexandre S Bezerra
Universidade Católica de Brasília Campus I, Curso de Medicina, EPCT QS 7 Lote 1, Taguatinga, Distrito Federal, Brazil, 71966 700
AJR Am J Roentgenol 184:1510-3. 2005Our objective was to determine if there is a single parameter that can be used as a marker of splenomegaly using CT.
- Hepatosplenomegaly associated with chronic malaria exposure: evidence for a pro-inflammatory mechanism exacerbated by schistosomiasisS Wilson
Department of Pathology, University of Cambridge, Cambridge, UK
Parasite Immunol 31:64-71. 2009..mansoni infected children, compared to those without detectable S. mansoni and malarial infections, but exposed to malaria, suggest that S. mansoni infection may augment the underlying inflammatory reaction...
- Exposure to malaria affects the regression of hepatosplenomegaly after treatment for Schistosoma mansoni infection in Kenyan childrenMark Booth
Division of Microbiology and Parasitology, Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QP, UK
BMC Med 2:36. 2004..The present analysis focused on the possibility that exposure to malaria infection may have limited the resolution of hepatosplenomegaly in a cohort of Kenyan schoolchildren...
- Regression of hepatosplenomegaly in Kenyan school-aged children after praziquantel treatment and three years of greatly reduced exposure to Schistosoma mansoniBirgitte J Vennervald
Danish Bilharziasis Laboratory, Charlottenlund, Denmark
Trans R Soc Trop Med Hyg 99:150-60. 2005..The prevalence of hard spleens, and the magnitude of clinically assessed splenomegaly along the mid-axillary and mid-clavicular lines decreased monotonically over time, independently of age, ..
- Frequency of Treg cells is reduced in CVID patients with autoimmunity and splenomegaly and is associated with expanded CD21lo B lymphocytesGururaj Arumugakani
Department of Clinical Immunology, Beckett Wing, St James s University Hospital, Leeds, UK
J Clin Immunol 30:292-300. 2010..The study was designed to evaluate the role of T regulatory (Treg) cells in common variable immunodeficiency (CVID) patients with autoimmunity...
- Spleen rates in children: an old and new surveillance tool for malaria elimination initiatives in island settingsLuis Fernando Chaves
Department of Environmental Studies, Emory University, Atlanta, GA 30322, USA
Trans R Soc Trop Med Hyg 105:226-31. 2011..Finally, results highlight the value of measuring spleen sizes to rapidly assess the impact of intervention packages aimed at malaria elimination or control...
- Health implications of chronic hepatosplenomegaly in Kenyan school-aged children chronically exposed to malarial infections and Schistosoma mansoniShona Wilson
Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QP, UK
Trans R Soc Trop Med Hyg 104:110-6. 2010..This study shows that hepatosplenomegaly associated with chronic exposure to malaria and schistosomiasis is not a benign symptom amongst school-aged children but has potential long-term health consequences...
- Spleen enlargement and genetic diversity of Plasmodium falciparum infection in two ethnic groups with different malaria susceptibility in Mali, West AfricaS Bereczky
Infectious Diseases Unit, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden
Trans R Soc Trop Med Hyg 100:248-57. 2006..Moreover, splenomegaly was increased in individuals with clinical malaria in the Dogon, odds ratio 3.67 (95% CI 1.65-8.15, P=0...
- Hemophagocytic syndromesGritta E Janka
Department of Hematology and Oncology, Children s Hospital, University of Hamburg, Martinistrasse 52, 20246 Hamburg, Germany
Blood Rev 21:245-53. 2007..Awareness of the clinical symptoms and of the diagnostic criteria of HLH is important to start life-saving therapy with immunosuppressive/immunomodulatory agents in time...
- Hyperreactive malaria in expatriates returning from sub-Saharan AfricaJ van den Ende
Institute of Tropical Medicine, Antwerp, Belgium University Hospital Antwerp, Edegem, Belgium
Trop Med Int Health 5:607-11. 2000The extreme presentation of hyperreactive malaria is hyperreactive malarial splenomegaly syndrome (HMS). Some patients present with a less pronounced syndrome...
- Avian hepatitis E virus in an outbreak of hepatitis--splenomegaly syndrome and fatty liver haemorrhage syndrome in two flaxseed-fed layer flocks in OntarioA C Agunos
Department of Pathobiology, Ontario Veterinary College, University of Guelph, Guelph, Ontario, Canada
Avian Pathol 35:404-12. 2006..had lesions in the liver and spleen, with 44% of those necropsied having changes consistent with hepatitis-splenomegaly syndrome, with lesions ranging from acute periportal lymphoplasmacytic hepatitis to chronic severe ..
- Role of spleen enlargement in cirrhosis with portal hypertensionM Bolognesi
Department of Clinical and Experimental Medicine, University of Padua, Italy
Dig Liver Dis 34:144-50. 2002The possible relationships between splenomegaly and portal hypertension have been analysed in patients with cirrhosis...
- Splenomegaly in myelofibrosis--new options for therapy and the therapeutic potential of Janus kinase 2 inhibitorsJasleen Randhawa
Medical College of Wisconsin, Milwaukee, WI, USA
J Hematol Oncol 5:43. 2012b>Splenomegaly is a common sign of primary myelofibrosis (PMF), post-polycythemia vera myelofibrosis (post-PV MF), and post-essential thrombocythemia myelofibrosis (post-ET MF) that is associated with bothersome symptoms, which have a ..
- Murine gammaherpesvirus-induced splenomegaly: a critical role for CD4 T cellsE J Usherwood
Department of Veterinary Pathology, University of Edinburgh, UK
J Gen Virol 77:627-30. 1996..In the first 2-3 weeks after infection mice develop a marked splenomegaly, where the spleen cell number increases by 2-3 fold...
- Urothelial cancer producing granulocyte colony-stimulating factor: possible induction of splenomegalySachi Kitayama
Department of Urology and Reproductive Medicine, Tokyo Medical and Dental University Graduate School, Tokyo, Japan
Urology 63:377-8. 2004
- Forest malaria in Chhindwara, Madhya Pradesh, central India: a case study in a tribal communityNeeru Singh
Malaria Research Centre, Jabalpur, Madhya Pradesh, India
Am J Trop Med Hyg 68:602-7. 2003..75 per 1,000 in 2000. Improved access to treatment facilities, combination therapy, and vector control using an effective insecticide appear to be the most promising methods for controlling malaria in this region...
- Radiotherapy for hypersplenism from congestive splenomegalyMu Tai Liu
Department of Radiation Oncology, Changhua Christian Hospital, Changhua, Taiwan
Ann Saudi Med 24:198-200. 2004
- Benzo(a)pyrene-induced anemia and splenomegaly in NZB/WF1 miceC D Booker
Virginia Commonwealth University Richmond, Virginia, USA
Food Chem Toxicol 43:1423-31. 2005..possibly caused by BaP exposure, or chemical-induced hemolysis, perhaps contributed to by erythrocyte fragility inherited from a parent strain, NZB, which spontaneously develops autoimmune hemolytic anemia and subsequent splenomegaly.
- Divergent synthetic nucleotide motif recognition pattern: design and development of potent immunomodulatory oligodeoxyribonucleotide agents with distinct cytokine induction profilesEkambar R Kandimalla
Hybridon, Inc, 345 Vassar Street, Cambridge, MA 02139, USA
Nucleic Acids Res 31:2393-400. 2003....
- Treatment of suspected hyper-reactive malarial splenomegaly (HMS) in pregnancy with mefloquineJuthamas Jaroensuk
Shoklo Malaria Research Unit SMRU, Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Mae Sot, Thailand Mahidol Oxford Tropical Medicine Research Unit MORU, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand Centre for Clinical Vaccinology and Tropical Medicine, Nuffield Department of Clinical Medicine, University of Oxford, Churchill Hospital, Oxford, United Kingdom
Am J Trop Med Hyg 90:609-11. 2014..There are few data on hyper-reactive malarial splenomegaly, an aberrant immunological response to chronic or recurrent malaria in pregnancy...
- Thrombocytopenia and splenomegaly: an unusual presentation of congenital hepatic fibrosisSerena Botto Poala
Clinic of Pediatric Hematology_Oncology, Department of Pediatrics, University of Padova, Padova, Italy
Orphanet J Rare Dis 5:4. 2010..We describe the first case of CHF presenting in an otherwise healthy child, with thrombocytopenia and splenomegaly as the only manifestations of the disease.
- Low-grade parasitaemias and cold agglutinins in patients with hyper-reactive malarious splenomegaly and acute haemolysisJ R Torres
Instituto de Medicina Tropical, Seccion de Enfermedades Infecciosas, Universidad Central de Venezuela, Apartado 47019, Caracas 1041 A, Venezuela
Ann Trop Med Parasitol 97:125-30. 2003A cluster of 16 cases of hyper-reactive malarious splenomegaly (HMS) with severe, acute haemolysis, from an isolated, Venezuelan, Yanomami population, was prospectively investigated...
- A phase 2 trial of combination low-dose thalidomide and prednisone for the treatment of myelofibrosis with myeloid metaplasiaRuben A Mesa
Division of Hematology and Internal Medicine, Mayo Clinic, Rochester, MN 55905, USA
Blood 101:2534-41. 2003..tolerability, we prospectively treated 21 symptomatic patients (hemoglobin level < 10 g/dL or symptomatic splenomegaly) with MMM with low-dose THAL (50 mg/d) along with a 3-month oral prednisone (PRED) taper (beginning at 0...
- Efficacy and tolerability of hydroxyurea in the treatment of the hyperproliferative manifestations of myelofibrosis: results in 40 patientsAlejandra Martínez-Trillos
Hematology Department, Hospital Clinic, IDIBAPS, University of Barcelona, Barcelona, Spain
Ann Hematol 89:1233-7. 2010..2 months (range 0-141.7). Reasons for treatment were constitutional symptoms (55%), symptomatic splenomegaly (45%), thrombocytosis (40%), leukocytosis (28%), pruritus (10%), and bone pain (8%)...
- Hyper-reactive malarial splenomegalyJohn L Ziegler
University of California San Francisco, San Francisco, California 94143 0808, USA
Am J Trop Med Hyg 78:186-7. 2008
- A case of hyper-reactive malarial splenomegaly. The role of rapid antigen-detecting and PCR-based testsB Mothe
Infectious Diseases Unit, Internal Medicine Department, Hospital de la Santa Creu i Sant Pau, Universitat de Barcelona, Barcelona, Spain
Infection 36:167-9. 2008Hyper-reactive malarial splenomegaly (HMS) - originally referred to as tropical splenomegaly syndrome - is characterized by a massive splenomegaly, high titres of anti-malarial antibodies and polyclonal IgM hypergammaglobulinemia...
- Rapamycin reverses splenomegaly and inhibits tumor development in a transgenic model of Epstein-Barr virus-related Burkitt's lymphomaOsman Cen
Department of Microbiology and Immunology, Feinberg School of Medicine, Northwestern University, 303 E Chicago Avenue, Ward 6 241, Chicago, IL 60611, USA
Mol Cancer Ther 10:679-86. 2011..the PI3K/Akt/mTOR pathway, we tested the therapeutic efficacy of mTOR inhibitor rapamycin on the tumors and splenomegaly in these double transgenic mice (Tg6/λ-MYC)...
- The use of PCR in the diagnosis of hyper-reactive malarial splenomegaly (HMS)S Puente
Servicio de Enfermedades Infecciosas, Hospital Carlos III, Instituto de Salud Carlos III Insalud, Madrid, Spain
Ann Trop Med Parasitol 94:559-63. 2000Between August 1997 and September 1998, 14 cases of hyper-reactive malarial splenomegaly (HMS) were diagnosed in the Instituto de Salud Carlos III in Madrid, Spain...
- Radiation therapy for palliation of Eisenmenger's syndrome-associated painful splenomegalyJonathan I Osorio
School of Medicine Medical University of South Carolina, Charleston, SC 29425, USA
Radiat Med 26:84-7. 2008Painful splenomegaly has a clinical presentation that is often associated with myeloproliferative disorders, such as acute or chronic lymphoblastic or myelogenous leukemia...
- Role of BI-1 (TEGT)-mediated ERK1/2 activation in mitochondria-mediated apoptosis and splenomegaly in BI-1 transgenic miceJung Hyun Kim
Department of Animal Biotechnology, Konkuk University, Seoul, South Korea
Biochim Biophys Acta 1823:876-88. 2012..Interestingly, we found that BI-1 TG mice showed splenomegaly and abnormal megakaryopoiesis...
- Role for inducible costimulator in control of Salmonella enterica serovar Typhimurium infection in miceMariana Vidric
Department of Immunology, University of Toronto, 1 King s College Circle, Toronto, Ontario, Canada M5S 1A8
Infect Immun 74:1050-61. 2006..ICOS-/- mice exhibited greater splenomegaly than WT mice and showed delayed bacterial clearance...
- The morbidity of schistosomiasis mansoni in the Rusizi Plain (Burundi)B Gryseels
Laboratory for Parasitology, State University of Leiden, The Netherlands
Trans R Soc Trop Med Hyg 82:582-7. 1988..was found in 26% of those infected, and in 10% of those not infected; right lobe hepatomegaly in 7% and 5%, and splenomegaly in 30% and 24%, respectively...
- Laparoscopic and open splenectomy for splenomegaly secondary to liver cirrhosis: an evaluation of immunityZhong Wu
Department of Hepatopancreatobiliary Surgery, West China Hospital, Sichuan University, Chengdu, 610041, China
Surg Endosc 26:3557-64. 2012We sought to investigate the perioperative inflammatory response and immunological function of patients with portal hypertension-induced splenomegaly who underwent laparoscopic (LS) or open splenectomy (OS).
- Validation of PCR for detection and characterization of parasitaemia in massive splenomegaly attributed clinically to malaria infectionSalwa M E A-Elgayoum
Department of Zoology, Faculty of Science, University of Khartoum, P O Box 321, Khartoum, Sudan
Diagn Microbiol Infect Dis 70:207-12. 2011In this study, 101 patients with massive splenomegaly (MS) and 41 with moderate splenomegaly (MoS) from Kassala, Eastern Sudan, were included...
- Radiotherapy of splenomegaly : a palliative treatment option for a benign phenomenon in malignant diseasesJan Kriz
Department of Radiation Oncology, University of Cologne, Cologne, Germany
Strahlenther Onkol 187:221-4. 2011Since the 20(th) century, radiotherapy (RT) has been used for treatment of symptomatic splenomegaly (SM). SM occurs in association with hematologic disorders...
- Hyper-reactive Malarial Splenomegaly (HMS) in malaria endemic area in Eastern SudanMushal M Allam
Institute of Endemic Diseases, University of Khartoum, P O Box 102, Khartoum, Sudan
Acta Trop 105:196-9. 2008Hyper-reactive Malarial Splenomegaly (HMS) is massive enlargement of the spleen resulting from abnormal immune response to repeated attacks of malaria...
- Histopathological and molecular features of persistent polyclonal B-cell lymphocytosis (PPBL) with progressive splenomegalyIlaria del Giudice
Department of Cellular Biotechnologies and Haematology, Division of Haematology, Sapienza University, Rome, Italy
Br J Haematol 144:726-31. 2009Five cases of persistent polyclonal B-cell lymphocytosis (PPBL) with progressive splenomegaly are reported; three were splenectomized. BCL2/IGH rearrangements were found in three cases; HLA-DRB1*07 in all...
- Is the laparoscopic approach reasonable in cases of splenomegaly?Eduardo Ma Targarona
Service of General and Digestive Surgery, Hospital de Sant Pau, Autonomous University of Barcelona, Barcelona, Spain
Semin Laparosc Surg 11:185-90. 2004Laparoscopic splenectomy in cases of splenomegaly has been shown to be feasible in experienced hands, even though the size of the spleen increases the operative time and difficulty...
- Splenomegaly in FOLFOX-naïve stage IV or recurrent colorectal cancer patients due to chemotherapy-associated hepatotoxicity can be predicted by the aspartate aminotransferase to platelet ratio before chemotherapyKazuhiro Miura
Department of Gastroenterological Surgery, St Marianna University Hospital, St Marianna University School of Medicine, 2 16 1 Sugao, Miyamae ku, Kawasaki 216 8511, Japan
Int J Clin Oncol 16:257-63. 2011Chemotherapy-associated hepatotoxicity is a common cause of postoperative complications after major hepatectomy. Splenomegaly may indicate portal hypertension due to chemotherapy...
- Immunostimulatory activity of CpG oligonucleotides containing non-ionic methylphosphonate linkagesD Yu
Hybridon Inc, 345 Vassar Street, Cambridge, MA 02139, USA
Bioorg Med Chem 9:2803-8. 2001..These results have significance in understanding CpG oligonucleotide-receptor interactions and the development of potent immunomodulatory agents...
- Staple line bleeding following laparoscopic splenectomy: intraoperative prevention and postoperative management with splenic artery embolizationKent W Kercher
Department of Surgery, University of Massachusetts Medical School, Worcester, MA 01655, USA
Surg Laparosc Endosc Percutan Tech 13:353-6. 2003..In this paper we identify and discuss important technical aspects of obtaining hilar vascular control during LS and report the first use of postoperative splenic artery embolization to control staple line bleeding following LS...
- The AMPKγ1 subunit plays an essential role in erythrocyte membrane elasticity, and its genetic inactivation induces splenomegaly and anemiaMarc Foretz
Institut Cochin, Département d Endocrinologie Métabolisme et Cancer, 24 rue du Faubourg St Jacques, 75014 Paris, France
FASEB J 25:337-47. 2011..Prkag1(-/-) mice displayed splenomegaly and iron accumulation due to compensatory splenic erythropoiesis and erythrophagocytosis...
- A multicenter retrospective study of childhood brucellosis in Chicago, Illinois from 1986 to 2008Latania K Logan
Rush University Medical Center, 1653 West Congress Parkway, Suite 736 Murdock, Chicago, IL 60612, USA
Int J Infect Dis 15:e812-7. 2011..To determine risk factors in children for the acquisition of Brucella, clinical presentation, treatment, and disease outcomes...
- [Successful management with partial splenic embolization (PSE) of splenomegaly and thrombocytopenia caused by oxaliplatin-based chemotherapy for advanced colorectal cancer]Keiichiro Hiramoto
Dept of Gastroenterology, Yamagata City Hospital Saiseikan
Gan To Kagaku Ryoho 38:835-9. 2011..which received chemotherapy, in which partial splenic embolization (PSE) had been effective for controlling splenomegaly and thrombocytopenia. Case 1: A 50-year-old man presented with bloody urine and bloody stool...
- Lymphotoxin-alpha-deficient mice can clear a productive infection with murine gammaherpesvirus 68 but fail to develop splenomegaly or lymphocytosisB J Lee
La Jolla Institute for Allergy and Immunology, San Diego, California 92121, USA
J Virol 74:2786-92. 2000..The virus also induces splenomegaly and an increase in the number of activated CD8 T cells in the circulation...
- Trends in laparoscopic splenectomy for massive splenomegalySarah W Grahn
Department of Surgery, University of California, San Francisco, USA
Arch Surg 141:755-61; discussion 761-2. 2006..During the past 10 years, expertise with minimally invasive techniques has grown, leading to an increase in successful laparoscopic splenectomy (LS) even in the setting of massive and supramassive spleens...
- Analysis of risk factors for massive intraoperative bleeding during laparoscopic splenectomyMasayuki Ohta
First Department of Surgery, Oita University Faculty of Medicine, 1 1 Idaigaoka, Hasama machi, Yufu, Oita, 879 5593, Japan
J Hepatobiliary Pancreat Surg 12:433-7. 2005..Laparoscopic splenectomy is occasionally converted to open surgery due to massive intraoperative bleeding. The aim of this study was to identify the risk factors for massive bleeding during laparoscopic splenectomy...
- Low dose palliative radiotherapy for splenomegaly in hematologic disordersKonstantin Lavrenkov
Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel
Leuk Lymphoma 53:430-4. 2012b>Splenomegaly (SM) is a common complication in hematologic disorders often associated with hypersplenism, and may cause pain, epigastric discomfort and variable systemic effects due to cytopenias...
- Dasatinib therapy results in decreased B cell proliferation, splenomegaly, and tumor growth in a murine model of lymphoma expressing Myc and Epstein-Barr virus LMP2AJamie L Dargart
Department of Microbiology Immunology, Northwestern University Feinberg School of Medicine, 303 E Chicago Avenue, Ward 6 245, Chicago, IL, USA
Antiviral Res 95:49-56. 2012..LMP2A/λ-MYC double transgenic mice develop splenomegaly and cervical lymphomas starting at 8 weeks of age...
- The feasibility and safety of laparoscopic splenectomy for massive splenomegaly: a comparative studyJin Zhou
Department of Gastrointestinal Surgery, West China Hospital, Sichuan University, Chengdu, Sichuan, China
J Surg Res 171:e55-60. 2011Laparoscopic splenectomy used for massive splenomegaly is still controversial. The purpose of our current study was to identify the feasibility and safety of laparoscopic splenectomy for massive splenomegaly.
- Adjuvant FOLFOX chemotherapy and splenomegaly in patients with stages II-III colorectal cancerRevathi Angitapalli
Arlington Cancer Center, Arlington, TX, USA
Oncology 76:363-8. 2009..We conducted a retrospective study to assess the effects of adjuvant FOLFOX chemotherapy on the splenic index (SI) as a surrogate marker for portal hypertension...
- Laparoscopic splenectomy in patients with normal-sized spleens versus splenomegaly: does size matter?B T Heniford
Department of Surgery and Medicine, Carolinas Medical Center, Charlotte, North Carolina 28232, USA
Am Surg 67:854-7; discussion 857-8. 2001..The application of minimally invasive techniques in the setting of splenomegaly is less well defined and was previously considered a contraindication to the laparoscopic approach...
- Reappraisal of anterior approach to laparoscopic splenectomy: technical feasibility and its clinical applicationSung Hoon Choi
Department of Surgery, Yonsei University College of Medicine, Clinic of Pancreatic and Biliary Cancer, Institute of Gastroenterology, Yonsei University Health System, Seoul, Korea
Surg Laparosc Endosc Percutan Tech 21:353-7. 2011..The presented technique of modified laparoscopic splenectomy seems to be a feasible, easy, and safe procedure. It is also thought that surgical indication could be extended even to the splenomegaly by this technique.
- Hand-assisted laparoscopic splenectomy versus open splenectomy for massive splenomegaly: 20-year experience at a Canadian centreTodd W Swanson
Department of Surgery, University of British Columbia, Vancouver, Canada
Can J Surg 54:189-93. 2011..Concerns regarding a purely laparoscopic splenectomy for massive splenomegaly (> 20 cm) arise from potentially longer operative times, higher conversion rates and increased blood loss...
- Surgical treatment of massive splenomegaly and severe hypersplenism secondary to extrahepatic portal venous obstruction in childrenRoy Choudhury Subhasis
Department of Pediatric Surgery, Lady Hardinge Medical College, New Delhi 110001, India
Surg Today 37:19-23. 2007Massive splenomegaly with severe hypersplenism can occur as a late complication of portal hypertension (PH) caused by extrahepatic portal venous obstruction (EHPVO) in children...
- Sickle cell disease and hyperreactive malarial splenomegaly (HMS) in young immigrants from AfricaLucia De Franceschi
Blood 106:4415-7. 2005
- [Hyperreactive malarial splenomegaly: three clinical cases and literature review]B Camara
Service de Maladies Infectieuses et Tropicales, Hopital Purpan, 1, Place Baylac, 31059 Toulouse, Cedex 9, France
Med Mal Infect 39:29-35. 2009Hyperreactive malarial splenomegaly (HMS) is the chronic stage of a long-term stimulation of the immune system secondary to plasmodial infections, more frequently in genetically predisposed patients...
- [The clinical application of splenectomy in pyrexia of unknown origin with splenomegaly]Han Ying Sun
Department of Hematology, Tongji Hospital, Tongji Medical College, Huazhong Science and Technology University, Wuhan 430030, China
Zhonghua Nei Ke Za Zhi 44:89-91. 2005To observe the clinical value of splenectomy for pathologic diagnosis in fever of unknown origin with splenomegaly only.
- Hyper-reactive malarial splenomegaly in a patient with human immunodeficiency virusG De Iaco
Infectious and Tropical Medicine Institute, University of Brescia, Italy
Am J Trop Med Hyg 78:239-40. 2008Both hyperreactive malarial splenomegaly (HMS) and HIV infection are highly prevalent in sub-Saharan Africa, but the inter-relationships between the two conditions are not clearly defined...
- Isolated splenic tuberculosis presenting with splenomegaly and pyrexia of unknown originSatyendra K Tiwary
ANZ J Surg 78:322-3. 2008
- Patients with unusual bladder malignancies and a rare cause of splenomegaly. Case 2. Rhabdomyosarcoma of the urinary bladder in an adultMohammadbagher Ziari
Department of Hematology and Oncology, Baylor College of Medicine, Houston, TX, USA
J Clin Oncol 23:4459-60. 2005
- Association of Plasmodium falciparum isolates encoding the p. Falciparum chloroquine resistance transporter gene K76T polymorphism with anemia and splenomegaly, but not with multiple infectionsInas Z Abdel-Aziz
Hygiene Institut, Abteilung Parasitologie, Universitatsklinikum Heidelberg, Heidelberg, Germany
Am J Trop Med Hyg 72:252-5. 2005..regression analysis showed that pfcrt K76T-carrying isolates are significantly more likely to cause anemia and splenomegaly. Furthermore, we found that infections with P...
- The morbidity of schistosomiasis mansoni in the highland focus of Lake Cohoha, BurundiB Gryseels
Project Bilharziose, Ministry of Health Belgian Cooperation Agency, Bujumbura, Burundi
Trans R Soc Trop Med Hyg 84:542-7. 1990..7%, 2%, and 1%; of left lobe hepatomegaly 30%, 18%, and 9%; of right lobe hepatomegaly 18%, 10%, and 5%; of splenomegaly 18%, 10%, and 7%. Organomegaly was generally mild, even in area A...
- Bacteremia, fever, and splenomegaly caused by a newly recognized bartonella speciesMarina E Eremeeva
Centers for Disease Control and Prevention, Atlanta, USA
N Engl J Med 356:2381-7. 2007..We describe a patient who had fever and splenomegaly after traveling to Peru and also had bacteremia from an organism that resembled Bartonella bacilliformis, the ..
- JAK inhibition with ruxolitinib versus best available therapy for myelofibrosisClaire Harrison
Guy s and St Thomas National Health Service Foundation Trust, Guy s Hospital, London, United Kingdom
N Engl J Med 366:787-98. 2012..Treatment options for myelofibrosis are limited. We evaluated the efficacy and safety of ruxolitinib, a potent and selective Janus kinase (JAK) 1 and 2 inhibitor, as compared with the best available therapy, in patients with myelofibrosis...
- Hepatosplenomegaly is associated with low regulatory and Th2 responses to schistosome antigens in childhood schistosomiasis and malaria coinfectionShona Wilson
Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QP, United Kingdom
Infect Immun 76:2212-8. 2008....
- Genetic identification and characterization of a novel virus related to human hepatitis E virus from chickens with hepatitis-splenomegaly syndrome in the United StatesG Haqshenas
Center for Molecular Medicine and Infectious Diseases, Department of Biomedical Sciences and Pathobiology, College of Veterinary Medicine, Virginia Polytechnic Institute and State University, 1410 Price's Fork Road, Blacksburg, VA 24061-0342, USA
J Gen Virol 82:2449-62. 2001Hepatitis-splenomegaly (HS) syndrome is an emerging disease in chickens in North America; the cause of this disease is unknown...
- A double-blind, placebo-controlled trial of ruxolitinib for myelofibrosisSrdan Verstovsek
Leukemia Department, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
N Engl J Med 366:799-807. 2012..Ruxolitinib, a selective inhibitor of Janus kinase (JAK) 1 and 2, has clinically significant activity in myelofibrosis...
- AML1 deletion in adult mice causes splenomegaly and lymphomasG Putz
Max Planck Institute for Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, 01307 Dresden, Germany
Oncogene 25:929-39. 2006..Metastatic lymphomas to the liver and the meninges were observed. Mice also developed splenomegaly with an expansion of the myeloid compartment. Increased Howell-Jolly body counts indicated splenic hypofunction...
- Hepatosplenomegaly in Kenyan schoolchildren: exacerbation by concurrent chronic exposure to malaria and Schistosoma mansoni infectionShona Wilson
Department of Pathology, University of Cambridge, Cambridge, UK
Trop Med Int Health 12:1442-9. 2007..We investigated the role of chronic malaria in childhood hepatosplenomegaly in the presence and absence of concurrent S. mansoni infection...
- Combined deficiency of proapoptotic regulators Bim and Fas results in the early onset of systemic autoimmunityJack Hutcheson
Department of Molecular Microbiology and Immunology, School of Medicine, Saint Louis University, Saint Louis, MO 63104, USA
Immunity 28:206-17. 2008..These data demonstrate that dysregulation of the Bcl-2 or Fas pathways can alter the function of APCs, thereby leading to SLE pathogenesis...
- Non-invasive predictors of the presence of large oesophageal varices in patients with cirrhosisK C Thomopoulos
Department of Internal Medicine, Division of Gastroenterology University Hospital of Patras, Patras, Greece
Dig Liver Dis 35:473-8. 2003..The aim of the present study was to determine whether clinical or laboratory non-endoscopic parameters could predict the presence of large oesophageal varices...
- Micro-geographical variation in exposure to Schistosoma mansoni and malaria, and exacerbation of splenomegaly in Kenyan school-aged childrenMark Booth
Division of Microbiology and Parasitology, Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QP, UK
BMC Infect Dis 4:13. 2004..They both cause enlargement of the spleen, but their relative contribution to the condition of splenomegaly remains unknown in areas where both infections are endemic...
- Disruption of the Gardos channel (KCa3.1) in mice causes subtle erythrocyte macrocytosis and progressive splenomegalyIvica Grgic
Department of Internal Medicine Nephrology, Faculty of Medicine, Philipps University, 35033 Marburg, Germany
Pflugers Arch 458:291-302. 2009..Deformability to increasing shear stress was unchanged. Strikingly, K(Ca)3.1(-/-)-mice developed progressive splenomegaly which was considerable ( approximately 200% of controls) in the >6-month-old mice and was paralleled by ..
- Association of splenomegaly with cerebral malaria and decreased concentrations of reactive nitrogen intermediates in ThailandM Nacher
Institut National de la Santé et de la Recherche Médicale Unité 511, Immunobiologie Cellulaire et Moleculaire des Infections Parasitaires, Faculté de Médecine Pitié Salpêtrière, Paris, France
Am J Trop Med Hyg 65:639-43. 2001..In Thailand, malaria transmission is low and splenomegaly is rarer than in high transmission areas...
- Inhibition of receptor tyrosine kinases restores immunocompetence and improves immune-dependent chemotherapy against experimental leishmaniasis in miceJane E Dalton
Centre for Immunology and Infection, Hull York Medical School and Department of Biology, University of York, United Kingdom
J Clin Invest 120:1204-16. 2010..of the broad-spectrum RTKI sunitinib maleate (Sm) blocked the vascular remodeling and progressive splenomegaly associated with experimental visceral leishmaniasis...
- Splenomegaly: investigation, diagnosis and managementAnna L Pozo
Norfolk and Norwich University Hospital, Norwich, United Kingdom
Blood Rev 23:105-11. 2009b>Splenomegaly is a feature of a broad range of diseases, and presents to clinicians in many fields...
- JAK2 V617F mutational status predicts progression to large splenomegaly and leukemic transformation in primary myelofibrosisGiovanni Barosi
Unit of Clinical Epidemiology and Center for the Study of Myelofibrosis, Istituto di Ricovero e Cura a Carattere Scientifico IRCCS Policlinico S Matteo Foundation, Pavia, Italy
Blood 110:4030-6. 2007..Adjusting for conventional risk factors, V617F mutation independently predicted the evolution toward large splenomegaly, need of splenectomy, and leukemic transformation...
- Hepatosplenic morbidity in two neighbouring communities in Uganda with high levels of Schistosoma mansoni infection but very different durations of residenceM Booth
Dept of Pathology, University of Cambridge, Tennis Court Rd, Cambridge CB2 1QP, UK
Trans R Soc Trop Med Hyg 98:125-36. 2004..This parameter should therefore be a routine measurement during epidemiological surveys of S. mansoni...
- Laparoscopic splenectomy for massive splenomegalyKent W Kercher
Department of General Surgery, Carolinas Medical Center, P O Box 32861, Charlotte, NC 28232, USA
Am J Surg 183:192-6. 2002Laparoscopic splenectomy (LS) is the preferred operative approach for diseases involving normal-sized spleens. Our experience with laparoscopic splenectomy in the setting of massive splenomegaly is presented.
- Hereditary thrombocytosis caused by MPLSer505Asn is associated with a high thrombotic risk, splenomegaly and progression to bone marrow fibrosisLuciana Teofili
Department of Hematology, Catholic University, Rome, Italy
Haematologica 95:65-70. 2010..Recently, we detected this mutation in a large proportion of children with familial thrombocythemia, suggesting that in Italy the incidence of MPL(Ser505Asn) mutation could be underestimated...
- Clinical and laboratory predictors of esophageal varices in children and adolescents with portal hypertension syndromeEleonora Druve Tavares Fagundes
Department of Pediatrics, Hospital das Clinicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil
J Pediatr Gastroenterol Nutr 46:178-83. 2008..To determine the clinical and laboratory parameters that may predict the presence of esophageal varices in children and adolescents with portal hypertension...
- Detailed clinical and ultrasound examination of children and adolescents in a Schistosoma mansoni endemic area in Kenya: hepatosplenic disease in the absence of portal fibrosisBirgitte J Vennervald
Danish Bilharziasis Laboratory, Charlottenlund, Denmark
Trop Med Int Health 9:461-70. 2004..These results indicate that hepatosplenic disease in school-aged children attributable to S. mansoni infection, involving hepatosplenomegaly and increased portal vein diameter, can occur in the absence of peri-portal fibrosis...
- Malaria morbidity and immunity among residents of villages with different Plasmodium falciparum transmission intensity in North-Eastern TanzaniaJohn P A Lusingu
National Institute for Medical Research, Amani Medical Research Centre, Amani and NIMR Headquarters, Dar es Salaam, Tanzania
Malar J 3:26. 2004..The relationship between the burden of uncomplicated malaria and transmission intensity is unclear and a better understanding of this relationship is important for the implementation of intervention programmes...
- Potent and selective inhibition of polycythemia by the quinoxaline JAK2 inhibitor NVP-BSK805Fabienne Baffert
Disease Area Oncology, Novartis Institutes for BioMedical Research, 4057 Basel, Switzerland
Mol Cancer Ther 9:1945-55. 2010..The inhibitor was efficacious in suppressing leukemic cell spreading and splenomegaly in a Ba/F3 JAK2(V617F) cell-driven mouse mechanistic model...
- Enhanced splenomegaly and severe liver inflammation in haptoglobin/hemopexin double-null mice after acute hemolysisEmanuela Tolosano
Department of Genetics, Biology and Biochemistry, University of Turin and the San Giovanni Battista Hospital, Turin, Italy
Blood 100:4201-8. 2002..alteration in phenotype under basal conditions, nonlethal hemolytic stress in these animals led to pronounced splenomegaly as well as liver inflammation and fibrosis...
- Murine mammary carcinoma 4T1 induces a leukemoid reaction with splenomegaly: association with tumor-derived growth factorsKenneth W Hunter
Department of Microbiology and Immunology, University of Nevada School of Medicine, Reno, NV 89557, USA
Exp Mol Pathol 82:12-24. 2007A leukemoid reaction with granulocytosis and splenomegaly has been observed in animals and humans with a variety of tumors...
- Ethnic differences in the prevalence of splenomegaly and malaria in The GambiaB M Greenwood
Medical Research Council Laboratories, Fajara, Banjul, The Gambia
Ann Trop Med Parasitol 81:345-54. 1987Significant variations in the prevalence of splenomegaly were found among members of the three main ethnic groups resident in North Bank Division, The Gambia...
- Host genetic control of recovery from Friend leukemia virus-induced splenomegaly: mapping of a gene within the major histocompatability complexB Chesebro
J Exp Med 140:1457-67. 1974..F(1) mice which were H-2(b/b) had a high incidence of recovery from splenomegaly compared to H-2(b/d) or H-2(b/a) mice...
- Genetic dissection of lupus pathogenesis: a recipe for nephrophilic autoantibodiesC Mohan
Simmon s Arthritis Research Center, Center for Immunology, University of Texas Southwestern Medical School, Dallas 75235 8884, USA
J Clin Invest 103:1685-95. 1999..NZMc1|c7 mice, bicongenic for Sle1 and Sle3, exhibit splenomegaly, significantly expanded populations of activated B and CD4(+) T cells, and a robust, variegated IgG ..
- Gaucher's disease with Parkinson's disease: clinical and pathological aspectsB Bembi
Unità Operativa Dipartimentale di Malattie Metaboliche, I R C C S Burlo Garofolo, Trieste, Italy
Neurology 61:99-101. 2003..The authors describe four patients (two siblings) with type 1 Gaucher disease presenting with the following signs of typical PD: asymmetric onset of rigidity, resting tremor, bradykinesia, and a favorable response to Parkinson therapies...
- Isolated splenomegaly as the presenting feature of Niemann-Pick disease type CJ Imrie
Willink Biochemical Genetics Unit, Royal Manchester Children's Hospital, Manchester M27 4HA, UK
Arch Dis Child 84:427-9. 2001..If the diagnosis is not considered and established, the family are at risk of having further affected children. Investigation of patients with isolated splenomegaly is not complete until NPC has been excluded.
- Autoimmune disease in Lyn-deficient mice is dependent on an inflammatory environment established by IL-6Evelyn Tsantikos
Signal Transduction Laboratory, Ludwig Institute for Cancer Research, Royal Melbourne Hospital, Victoria, Australia
J Immunol 184:1348-60. 2010..B cells, are able to produce IL-6, which facilitates hyperactivation of B and T cells, enhanced myelopoiesis, splenomegaly, and, ultimately, generation of pathogenic autoreactive Abs...
- Relationship between immunoglobulin isotype response to Plasmodium falciparum blood stage antigens and parasitological indexes as well as splenomegaly in sympatric ethnic groups living in MaliManijeh Vafa
Department of Immunology, Stockholm University, Svante Arrheniusväg 16, S 106 91 Stockholm, Sweden
Acta Trop 109:12-6. 2009..A positive correlation between elevated levels of anti-malarial IgG and IgG3 and splenomegaly was noted only within the Fulani group...
- Innate immune activation during Salmonella infection initiates extramedullary erythropoiesis and splenomegalyAmy Jackson
Center for Infectious Diseases and Microbiology Translational Research, Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, University of Minnesota Medical School, Minneapolis, MN 55455, USA
J Immunol 185:6198-204. 2010Systemic Salmonella infection commonly induces prolonged splenomegaly in murine or human hosts...
- Identification of Genes Involved in beta- ThelassemiaStefano Rivella; Fiscal Year: 2005..of the human beta-globin gene interferes with iron metabolism and leads to ineffective erythropoiesis, splenomegaly and osteopenia...
- Understand and Improve Iron Distribution and Erythropoiesis in Beta-ThalassemiaYelena Ginzburg; Fiscal Year: 2013..Beta-thalassemia in humans is a disease associated with anemia, splenomegaly, and ineffective erythropoiesis;iron overload in this disease results from transfusion and increased iron ..
- Functional analysis of Phospholipase D4David Nemazee; Fiscal Year: 2010..At three months of age these mice already exhibit evidence of multiorgan inflammation, splenomegaly, possible defects in B cell development and thymic selection, and excess numbers of activated and memory B and ..
- Caspase 8: A Novel Suppressor of Dendritic Cell-Mediated AutoimmunityCarla M Cuda; Fiscal Year: 2013..CreCD11cCasp8flox/flox mice display splenomegaly, lymphadenopathy, dsDNA-reactive autoantibodies, glomerulonephritis, immune complex deposition in the kidney, ..
- Immune and genetic determinants of murine glomerulonephritisElahna Paul; Fiscal Year: 2012..In addition to chronic kidney disease, features of the B6.CD48-/- phenotype include splenomegaly, hypergammaglobulinemia and autoantibody production...
- Regulation of Immunity and Inflammation by TIPE2Youhai H Chen; Fiscal Year: 2013..develop normally, but suffer from spontaneous inflammatory diseases characterized by multi- organ inflammation, splenomegaly, heightened inflammatory cytokine production and premature death...
- Novel Mechanisms of C-Kit Regulation in Mast CellsReuben Kapur; Fiscal Year: 2013..in Tet2 are associated with higher leukocyte counts, monocyte counts, serum tryptase levels, mast cell burden, splenomegaly and the presence of activating KIT mutation, KITD816V...
- KALLIKREIN KININ SYSTEM IN INFLAMMATORY BOWEL DISEASERobert Colman; Fiscal Year: 2001..edema, neutrophil infiltration), chronic intestinal inflammation and the systemic complications (arthritis, splenomegaly, hepatomegaly, leukocytosis, and the acute phase reaction...
- Genetics of Autoimmune Hemolytic AnemiaDwight H Kono; Fiscal Year: 2013..interval congenic mice demonstrated a marked reduction in autoimmune hemolytic anemia (AIHA) and consequent splenomegaly that was not associated with defects in immunoglobulin levels, anti-nuclear antibodies, or B cell activation...
- Molecular and Cellular Characterization of Myeloproliferative DiseaseKATHLEEN MIHO SAKAMOTO; Fiscal Year: 2010..These mice develop monocytosis, splenomegaly, and MPD...
- Innate Immunity in Experimental Arthritis of KininogenRobert Colman; Fiscal Year: 2007..inflammatory changes (edema, neutrophil infiltration) and prevented arthritis and the systemic complications (splenomegaly, hepatomegaly, leukocytosis and the acute phase reaction) in the PG-APS model...
- Targeting the mTOR signaling pathway in Autoimmune Lymphoproliferative SyndromeDavid T Teachey; Fiscal Year: 2011..Many patients with ALPS develop a severe form of the illness with significant lymphadenopathy, splenomegaly, autoimmune disease, and increased risk of malignancy...
- Targeting Akt signaling in Autoimmune Lymphoproliferative SyndromeDavid T Teachey; Fiscal Year: 2013..Many patients with ALPS develop a severe form of the illness with significant lymphadenopathy, splenomegaly, autoimmune disease, and increased risk of malignancy...
- SPLENIC TOXICITY OF ANILINEM Firoze Khan; Fiscal Year: 1999..methemoglobinemia and hemolytic anemia, aniline exposure also results in selective splenic toxicity leading to splenomegaly, hemorrhage, capsular hyperplasia, fibrosis and eventually a variety of sarcomas...
- Combination fusion toxin and cytarabine therapy of AMLARTHUR FRANKEL; Fiscal Year: 2002..with minimal disease burden (low or absent circulating blasts, <50 percent marrow replacement and no splenomegaly) responded best. No evidence of drug-related myelosuppression or neurotoxicity was observed...
- OLIGONUCLEOTIDE INHIBITION OF CELL PROLIFERATIONEric Wickstrom; Fiscal Year: 2000..b) Body weight, splenomegaly, cytokines, complement, liver enzymes and complete blood count will be compared to identify the anti-c-myc ..
- ROLE OF AUTOREACTIVE T CELLS IN MURINE AIDSMohan Sopori; Fiscal Year: 1993..This infection causes rapid proliferation of lymphoid cells leading to lymphadenopathy, splenomegaly, hypergammaglobulinemia, and followed by profound immunosuppression affecting all aspects of cellular and ..
- Top3 Homologues in Lymphocyte Genome Stability and AgingALBERT SHAW; Fiscal Year: 2009..lifespan, aneuploidy in somatic and germ cells, ionizing and UV-B radiation sensitivity, and age-related splenomegaly and autoantibody production...
- The Role of Sphingolipids in Inflammatory Bowel DiseaseASHLEY SNIDER; Fiscal Year: 2009..colitis in bone marrow chimeric mice, and examine parameters of disease: such as weight loss, colon shortening, splenomegaly, histologic markers of disease, blood and tissue SK1 activity, as well as sphingolipid changes...
- POSITRON EMISSION TOMOGRAPHY IMAGING IN AIDSC Pauza; Fiscal Year: 1999..In these initial studies, FDG/PET showed a clear pathology (splenomegaly with activation) in acutely infected patients without CD4 depletion and distinguished acute infection from both ..
- Role of CD45 in Hematopoiesis and LymphomagenesisMichelle Hermiston; Fiscal Year: 2005..These mice develop a profound lymphoproliferative disorder with polyclonal activation of T and B cells, massive splenomegaly, and premature death...
- CHEMOKINES IN THE IMMUNE RESPONSE TO A VIRAL INFECTIONSally Sarawar; Fiscal Year: 2002..MHV-68 also induces lymph node enlargement, splenomegaly, and mononucleosis in mice, as Epstein Barr virus does in humans...
- LEUKEMIA VIRUS PROJECTRobert Peters; Fiscal Year: 1993..Mice are evaluated for general health, and specifically examined for splenomegaly and lymphadenopathy, respiratory distress, and signs of neurologic disease...
- PARTICULATE CONTRAST AGENTS FOR MRIDavid Stark; Fiscal Year: 1992..cell function by MRI may allow differential diagnosis of splenic lymphoma and the common benign causes of splenomegaly. LD50, iron metabolism, and other indices of potential toxicity will be used to decide which new materials are ..
- CELL CYCLE AND APOPTOSIS REGULATION BY NFATAnjana Rao; Fiscal Year: 2006..In Aim 1, the lymphoproliferative phenotype of NFATI-/- mice will be analyzed, asking specifically whether the splenomegaly and lymphadenopathy of NFATI-/- mice are associated with any malignant transformation of lymphocytes and ..
- FRIEND VIRUS SUSCEPTIBILITY IN YOUNG AND AGED MICEDENEEN STEWART; Fiscal Year: 1993..This will be accomplished by determining the degree of splenomegaly. 2. Examine difference in viral replication and expression of FV in target organsof young and aged mice...
- Intracellular Signaling Triggered by Tall-1/BCMAHong Bing Shu; Fiscal Year: 2005..of TALL-1 in mice leads to autoimmune-like manifestations, such as increased number of mature B-cells, splenomegaly, anti-DNA antibodies, and nephritis...
- MURINE RETROVIRAL MODEL FOR HIV DRUG EVALUATIONThomas Merigan; Fiscal Year: 1992..nodes by 100-1000 fold, as well as serum immunoglobulin levels, B, CD4+, and Macl+ cell proliferation, and splenomegaly and lymphadenopathy...
- Apoptosis in myelofibrosis with myeloid metaplasiaRuben Mesa; Fiscal Year: 2006..with myeloid metaplasia is a clonal hematopoietic stem cell disorder that results in progressive cytopenias, splenomegaly, blastic transformation, and death. No broadly applicable therapy is available...
- SIVSMMPBJ SUPERANTIGEN AND VIRAL PATHOGENICITYZheng Chen; Fiscal Year: 1999..in vitro and induce an acutely lethal disease in macaques characterized, in part, by lymphadenopathy and splenomegaly. These unique properties of this isolate raise the possibility that this virus may indeed encode a superantigen ..
- Phospholipid signaling in B LymphocytesROBERT RICKERT; Fiscal Year: 2009..In addition, we will determine the extent to which Btk, PDK1 and Akt contribute to the splenomegaly/lymphadenopathy and altered B cell differentiation observed in mice lacking Pten in B cells and thus subject to ..
- Xenobiotics, Lipid Peroxidation and AutoimmunityM Firoze Khan; Fiscal Year: 2006..abstract_text> ..
- NIEMANN-PICK DISEASEMelissa Wasserstein; Fiscal Year: 2005..In sum, these studies should provide important diagnostic and therapeutic information to improve the outcome of patients diagnosed with NPD. ..
- SPLENIC TOXICITY OF ANILINEM Firoze Khan; Fiscal Year: 2010..These studies will elucidate the mechanisms of aniline-induced splenic toxicity, and will be important in devising strategies to prevent toxicity, and in risk assessment of aniline and other structurally-related aromatic amines. ..
- B Cell Expansion After Dendritic Cell ImmunizationMichael Jordan; Fiscal Year: 2004..My near term career path will involve ongoing basic research and study in order to improve my ultimate scientific productivity. ..
- NOS2 and arginase in visceral leishmaniasisPeter Melby; Fiscal Year: 2009..These studies in the hamster will fill a knowledge gap by defining mechanisms of disease and immunity that are strikingly different from those of the murine model. ..
- HU-UPCI Cancer Education/Career Development PartnershipRichard Steinman; Fiscal Year: 2006..abstract_text> ..
- RNA editing and its inhibition of HIV-1 replication in human macrophageYoshihiko Hoshino; Fiscal Year: 2007..These studies will establish if ADAR1 impacts on viral replication and mutation and will be the basis of further investigation on the impact of drug abuse on the expression of ADAR1. [unreadable] [unreadable] [unreadable]..
- Studies of Prosaposin's Physiologic RoleGregory Grabowski; Fiscal Year: 2007..These studies have implications for GSL metabolism, and lysosomal storage disease phenotypic expression and therapy. ..
- MOUSE MODELS TO STUDY THE ROLE OF TRAF1 AND TRAF2 IN THE ETIOLOGY OF LEUKEMIAJuan Zapata; Fiscal Year: 2007..Characterization of the CLL-like lymphoproliferative disorder caused by overexpression of TRAF2DN and Bcl-2 in B cells. [unreadable] [unreadable] [unreadable] [unreadable]..
- Dissection of the Anti-tumor Immune ResponseErik Ranheim; Fiscal Year: 2006..These studies will provide a clearer picture of CD4+ and CD8+ T cell anti-tumor immunity and better direct efforts at tumor immunotherapy in human patients. ..
- MENTORED PATIENT ORIENTED HEMATOLOGY RESEARCH TRAININGSujit Sheth; Fiscal Year: 2004..abstract_text> ..
- ANTIBODIES IN PATHOGENESIS OF HIV-1 TROMBOCYTOPENIAHenrik Ditzel; Fiscal Year: 2003..He will also look for molecular mimicry with foreign Ag's. ..
- Hematopoietic Potential of Skeletal Muscle CellsRonald Hoffman; Fiscal Year: 2004..abstract_text> ..
- ALLOCHIMERISM FOLLOWING HAPLOIDENTICAL STEM CELL TRANSPLRonald Hoffman; Fiscal Year: 2002..abstract_text> ..
- USING NOVEL TNF RECEPTORS TO ENHANCE IMMUNOTHERAPYAndrew Weinberg; Fiscal Year: 2002..Manipulating the combination of the 3 TNF-receptor family members in a tumor setting should help attain long-lived tumor immunity for both CD4+ and CD8+ T cells. ..
- Eighth Cooley's Anemia SymposiumElliott Vichinsky; Fiscal Year: 2005....
- ANTIBODIES IN PATHOGENESIS OF AUTOIMMUNE NEUTROPENIAHenrik Ditzel; Fiscal Year: 2002..3) Determine the pathogenesis of the cloned antibodies by generating intact human IgG1 antibodies from the cloned Fab fragments and testing for their ability to sensitize neutrophils by promoting ingestion by macrophages in vitro. ..
- ZOONOTIC AND XENOZOONOTIC RISKS OF HEPATITIS E VIRUSXiang Jin Meng; Fiscal Year: 2001..abstract_text> ..
- Mechanisms of MMP-3 Action in Acute Lung InjuryJames Varani; Fiscal Year: 2005..These studies will provide an overall understanding of the mechanism(s) by which MMP-3 contributes to acute lung injury. ..
- VACCINATION OF DOGS TO REDUCE TRANSMISSION OF LEISHMANIAPeter Melby; Fiscal Year: 2003..Successful vaccination of dogs in an endemic could reduce both enzootic (among the canine reservoir) and zoonotic (from the canine reservoir to humans) transmission. ..
- NOVEL APPROACHES TO IMPROVE AND EXTEND PLATELET STORAGESherrill Slichter; Fiscal Year: 2001....
- MOLECULAR TOOLS TO DEVELOP HAMSTER MODELS OF DISEASEPeter Melby; Fiscal Year: 2003..This work will have particular relevance to research traditionally funded through a number of NIH institutes including the NCI, NIAID, NHLBI, NIA, NIAMS, and NIDR. ..
- Modulation of Iron Deposition in SCD and Other HemoglobinopathiesELLIOTT P contact VICHINSKY; Fiscal Year: 2010....
- Molecular Mechanisms for IL-25-mediated Th2 ResponsesXiaoxia Li; Fiscal Year: 2010..With this improved understanding comes the potential to develop specific inhibitors of these pathways and perhaps novel therapeutics for the treatment of asthma. ..
- Phase 3 stem cell transplant for light chain amyloidosisMorie A Gertz; Fiscal Year: 2011..In addition, the analysis of clonal precursor B cells in the periphery and kinetics of amyloid formation of the monoclonal light chain will allow us to define and determine the mechanisms of disease progression and response to therapy. ..
- Candidate Gene Analysis in murine LupusChandra Mohan; Fiscal Year: 2002..Significance: These experiments have the potential to uncover the identity of a lupus susceptibility gene on murine chromosome 4, that potentially impacts B-cell hyperactivity, pathogenic ANA formation. and end-organ disease. ..
- FACTORS INFLUENCING STEM CELL AND PLATELET PRODUCTIONMalcolm Moore; Fiscal Year: 2002..e., adult populations acquiring features of neonatal cells, or whether there is a tendency for "immortalized" cells to undergo neoplastic transformation. ..
- DETERMINANTS OF HEPATITIS C & E MORBIDITY IN EGYPTGeorge Strickland; Fiscal Year: 2002..abstract_text> ..
- Phase II Trial of Thalidomide in Primary AmyloidosisAngela Dispenzieri; Fiscal Year: 2002..The ultimate goal of the proposed studies is to improve the prognosis of patient with this fatal disease. ..
- SIGIRR A Negative Regulator of Toll-IL-IR SignalingXiaoxia Li; Fiscal Year: 2009..Specifically, the proposed studies should result in significant advances in the field of innate mucosal immunity and should also help us to determine the potential of SIGIRR as a target for developing anti-inflammatory drugs. ..
- Act1 in CD40-/BAFFR-Mediated B Cell SurvivalXiaoxia Li; Fiscal Year: 2009..finding, Act1-deficient mice revealed a general increase in peripheral B cells, culminating in lymphadenopathy, splenomegaly, and the formation of autoantibodies...
- MOUSE MODELS TO STUDY MULIBREY NANISMJuan Zapata; Fiscal Year: 2005..study the developmental and phenotypic alterations of trim37 knock out and FINmajor-mutated trim37 mice. These mice will be the foundation for further studies on the biology and etiology of Mulibrey Nanism. ..
- Lupus locus, Sle3- innate and adaptive immunityChandra Mohan; Fiscal Year: 2005..In particular, biochemical and genetic studies will be carried out to determine if S/e3 might impact the My D88 or TRIF dependent signaling pathways. ..
- CpG Plus Rituximab Therapy in Follicular LymphomaArnold Freedman; Fiscal Year: 2005..This study is a novel approach to treating FL, where augmenting antigen presentation and effector cells may lead to enhanced cytotoxic effects of rituximab and induce anti-tumor immunity. ..
- Screen for Mycobacterium Tuberculosis (RMI)E White; Fiscal Year: 2005..tuberculosis. 3) To study the effect of these novel inhibitors on the pantothenate pathway in M. smegmatis. 4) To co-crystallize these compounds with pantothenate synthetase to study their mode of binding ..
- Molecular Pharmacology of Estrogen SulfotransferaseWenchao Song; Fiscal Year: 2006..The proposed studies will provide a molecular basis for understanding the in vivo pharmacology and physiology of estrogen sulfotransferase as a prototypical phase II steroid sulfoconjugation enzyme. ..
- A KINETIC STUDY OF INFLAMMATION-INDUCED HYPORETINEMIAFrancisco Rosales; Fiscal Year: 2005..In addition, the application of these methods and the development of a model of chronic inflammation will foster research on other micronutrients like iron and zinc that are similarly affected by inflammation. ..
- Impact of lupus susceptibility loci on B-cell toleranceChandra Mohan; Fiscal Year: 2007..Understanding how these loci/genes function will not only broaden our perspective of this disease, but will also point to potential targets for therapeutic intervention. ..
- Use of Hammerhead Ribozymes in Murine Models of OlGregory Grabowski; Fiscal Year: 2007....
- BRAIN CELL DEATH IN MRL MICE: TARGETS AND MECHANISMSBoris Sakic; Fiscal Year: 2004..abstract_text> ..
- Graduate Medical Education in GeneticsMargaret McGovern; Fiscal Year: 2004..abstract_text> ..
- ETIOLOGY OF STROKE IN CHILDREN WITH SICKLE CELL DISEASESherri Zimmerman; Fiscal Year: 2004..Based on this fact-finding study, I will design a hypothesis-driven therapeutic clinical trial for children at highest risk of developing stroke. ..
- INBORN ERRORS OF SPHINGOLIPID CATABOLISMGregory Grabowski; Fiscal Year: 2004..abstract_text> ..
- A Nucleosomal Biosensor for Identification and Isolation of Nuclear Hormone RecepRichard Steinman; Fiscal Year: 2008..This biosensor should be more rapid and versatile than cell-based reporter gene assays and more informative than assays that measure only ligand/receptor binding. [unreadable] [unreadable] [unreadable]..
- Mechanism of protection of DAF and CD59 in SLEWenchao Song; Fiscal Year: 2009..Such results should facilitate the development of innovative therapeutic strategies for human SLE. ..
- Etanercept Therapy in Follicular LymphomaArnold Freedman; Fiscal Year: 2003..This study is a novel approach to treating FL, where targeting the microenvironment of the tumor may inhibit the growth and survival of the neoplastic cells. ..
- MOLECULAR CONTRIBUTORS TO STEM CELL QUIESCENCERichard Steinman; Fiscal Year: 2003..Insights gained from these studies should have a significant impact on gene therapy strategies and should generate novel tools for the study of leukemias and myelodysplastic syndromes. ..
- Cell Cycle Inhibition in Systemic AutoimmunityDWIGHT KONO; Fiscal Year: 2009..These studies should yield important new insights into the significance and role of p21 in systemic autoimmunity and in host response to foreign antigens. ..