splenomegaly

Summary

Summary: Enlargement of the spleen.

Top Publications

  1. pmc Anemia and splenomegaly in cGKI-deficient mice
    Michael Foller
    Department of Physiology, Interfakultäres Institut für Biochemie, University of Tubingen, D72076 Tübingen, Germany
    Proc Natl Acad Sci U S A 105:6771-6. 2008
  2. pmc Silencing of microRNA-21 in vivo ameliorates autoimmune splenomegaly in lupus mice
    Barry G Garchow
    Division of Rheumatology, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, USA
    EMBO Mol Med 3:605-15. 2011
  3. ncbi Hyperreactive malarial splenomegaly in expatriates
    Ranjan K Singh
    District Hospital Daltonganj, Jharkhand, India
    Travel Med Infect Dis 5:24-9. 2007
  4. doi Relevance of the mTOR signaling pathway in the pathophysiology of splenomegaly in rats with chronic portal hypertension
    Marc Mejias
    Liver Unit, Institute of Biomedical Research IDIBAPS, CIBERehd, Hospital Clinic, University of Barcelona, Villarroel 170, Barcelona, Spain
    J Hepatol 52:529-39. 2010
  5. doi How I treat symptomatic splenomegaly in patients with myelofibrosis
    Ruben A Mesa
    Division of Hematology Oncology, Mayo Clinic Arizona, Scottsdale, AZ 85259, USA
    Blood 113:5394-400. 2009
  6. doi Haematological and biochemistry laboratory abnormalities associated with splenomegaly in asymptomatic adults in Masaka, Uganda: implications for HIV biomedical prevention trials
    Eugene Ruzagira
    Medical Research Council Uganda Virus Research Institute Uganda Research Unit on AIDS, Entebbe, Uganda
    Trop Med Int Health 15:105-12. 2010
  7. ncbi Determination of splenomegaly by CT: is there a place for a single measurement?
    Alexandre S Bezerra
    Universidade Católica de Brasília Campus I, Curso de Medicina, EPCT QS 7 Lote 1, Taguatinga, Distrito Federal, Brazil, 71966 700
    AJR Am J Roentgenol 184:1510-3. 2005
  8. pmc Hepatosplenomegaly associated with chronic malaria exposure: evidence for a pro-inflammatory mechanism exacerbated by schistosomiasis
    S Wilson
    Department of Pathology, University of Cambridge, Cambridge, UK
    Parasite Immunol 31:64-71. 2009
  9. pmc Exposure to malaria affects the regression of hepatosplenomegaly after treatment for Schistosoma mansoni infection in Kenyan children
    Mark Booth
    Division of Microbiology and Parasitology, Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QP, UK
    BMC Med 2:36. 2004
  10. ncbi Regression of hepatosplenomegaly in Kenyan school-aged children after praziquantel treatment and three years of greatly reduced exposure to Schistosoma mansoni
    Birgitte J Vennervald
    Danish Bilharziasis Laboratory, Charlottenlund, Denmark
    Trans R Soc Trop Med Hyg 99:150-60. 2005

Detail Information

Publications276 found, 100 shown here

  1. pmc Anemia and splenomegaly in cGKI-deficient mice
    Michael Foller
    Department of Physiology, Interfakultäres Institut für Biochemie, University of Tubingen, D72076 Tübingen, Germany
    Proc Natl Acad Sci U S A 105:6771-6. 2008
    ..By the age of 10 weeks, cGKI-deficient mice exhibited pronounced anemia and splenomegaly. Compared with control mice, the cGKI mutants had significantly lower red blood cell count, packed cell volume, ..
  2. pmc Silencing of microRNA-21 in vivo ameliorates autoimmune splenomegaly in lupus mice
    Barry G Garchow
    Division of Rheumatology, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, USA
    EMBO Mol Med 3:605-15. 2011
    ..B and T cells is up-regulated and that in vivo silencing of miR-21 using a tiny seed-targeting LNA reversed splenomegaly, one of the cardinal manifestations of autoimmunity in B6...
  3. ncbi Hyperreactive malarial splenomegaly in expatriates
    Ranjan K Singh
    District Hospital Daltonganj, Jharkhand, India
    Travel Med Infect Dis 5:24-9. 2007
    Hyperreactive malarial splenomegaly, one of the major causes of splenomegaly in tropics, has been often reported in expatriates of non-tropical settings...
  4. doi Relevance of the mTOR signaling pathway in the pathophysiology of splenomegaly in rats with chronic portal hypertension
    Marc Mejias
    Liver Unit, Institute of Biomedical Research IDIBAPS, CIBERehd, Hospital Clinic, University of Barcelona, Villarroel 170, Barcelona, Spain
    J Hepatol 52:529-39. 2010
    b>Splenomegaly is a frequent hallmark of portal hypertension that, in some cases, can be very prominent and cause symptoms like abdominal pain, splenic infarction, and cytopenia...
  5. doi How I treat symptomatic splenomegaly in patients with myelofibrosis
    Ruben A Mesa
    Division of Hematology Oncology, Mayo Clinic Arizona, Scottsdale, AZ 85259, USA
    Blood 113:5394-400. 2009
    ..MF patients have a range of debilitating disease manifestations (eg, massive splenomegaly, cytopenias, constitutional symptoms, and transformation to a treatment-refractory blast phase)...
  6. doi Haematological and biochemistry laboratory abnormalities associated with splenomegaly in asymptomatic adults in Masaka, Uganda: implications for HIV biomedical prevention trials
    Eugene Ruzagira
    Medical Research Council Uganda Virus Research Institute Uganda Research Unit on AIDS, Entebbe, Uganda
    Trop Med Int Health 15:105-12. 2010
    To assess the degree of haematological and biochemistry abnormalities associated with splenomegaly in asymptomatic adults in order to determine whether they may be eligible for inclusion in HIV biomedical prevention trials.
  7. ncbi Determination of splenomegaly by CT: is there a place for a single measurement?
    Alexandre S Bezerra
    Universidade Católica de Brasília Campus I, Curso de Medicina, EPCT QS 7 Lote 1, Taguatinga, Distrito Federal, Brazil, 71966 700
    AJR Am J Roentgenol 184:1510-3. 2005
    Our objective was to determine if there is a single parameter that can be used as a marker of splenomegaly using CT.
  8. pmc Hepatosplenomegaly associated with chronic malaria exposure: evidence for a pro-inflammatory mechanism exacerbated by schistosomiasis
    S Wilson
    Department of Pathology, University of Cambridge, Cambridge, UK
    Parasite Immunol 31:64-71. 2009
    ..mansoni infected children, compared to those without detectable S. mansoni and malarial infections, but exposed to malaria, suggest that S. mansoni infection may augment the underlying inflammatory reaction...
  9. pmc Exposure to malaria affects the regression of hepatosplenomegaly after treatment for Schistosoma mansoni infection in Kenyan children
    Mark Booth
    Division of Microbiology and Parasitology, Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QP, UK
    BMC Med 2:36. 2004
    ..The present analysis focused on the possibility that exposure to malaria infection may have limited the resolution of hepatosplenomegaly in a cohort of Kenyan schoolchildren...
  10. ncbi Regression of hepatosplenomegaly in Kenyan school-aged children after praziquantel treatment and three years of greatly reduced exposure to Schistosoma mansoni
    Birgitte J Vennervald
    Danish Bilharziasis Laboratory, Charlottenlund, Denmark
    Trans R Soc Trop Med Hyg 99:150-60. 2005
    ..The prevalence of hard spleens, and the magnitude of clinically assessed splenomegaly along the mid-axillary and mid-clavicular lines decreased monotonically over time, independently of age, ..
  11. doi Frequency of Treg cells is reduced in CVID patients with autoimmunity and splenomegaly and is associated with expanded CD21lo B lymphocytes
    Gururaj Arumugakani
    Department of Clinical Immunology, Beckett Wing, St James s University Hospital, Leeds, UK
    J Clin Immunol 30:292-300. 2010
    ..The study was designed to evaluate the role of T regulatory (Treg) cells in common variable immunodeficiency (CVID) patients with autoimmunity...
  12. doi Spleen rates in children: an old and new surveillance tool for malaria elimination initiatives in island settings
    Luis Fernando Chaves
    Department of Environmental Studies, Emory University, Atlanta, GA 30322, USA
    Trans R Soc Trop Med Hyg 105:226-31. 2011
    ..Finally, results highlight the value of measuring spleen sizes to rapidly assess the impact of intervention packages aimed at malaria elimination or control...
  13. pmc Health implications of chronic hepatosplenomegaly in Kenyan school-aged children chronically exposed to malarial infections and Schistosoma mansoni
    Shona Wilson
    Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QP, UK
    Trans R Soc Trop Med Hyg 104:110-6. 2010
    ..This study shows that hepatosplenomegaly associated with chronic exposure to malaria and schistosomiasis is not a benign symptom amongst school-aged children but has potential long-term health consequences...
  14. ncbi Spleen enlargement and genetic diversity of Plasmodium falciparum infection in two ethnic groups with different malaria susceptibility in Mali, West Africa
    S Bereczky
    Infectious Diseases Unit, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden
    Trans R Soc Trop Med Hyg 100:248-57. 2006
    ..Moreover, splenomegaly was increased in individuals with clinical malaria in the Dogon, odds ratio 3.67 (95% CI 1.65-8.15, P=0...
  15. ncbi Hemophagocytic syndromes
    Gritta E Janka
    Department of Hematology and Oncology, Children s Hospital, University of Hamburg, Martinistrasse 52, 20246 Hamburg, Germany
    Blood Rev 21:245-53. 2007
    ..Awareness of the clinical symptoms and of the diagnostic criteria of HLH is important to start life-saving therapy with immunosuppressive/immunomodulatory agents in time...
  16. ncbi Hyperreactive malaria in expatriates returning from sub-Saharan Africa
    J van den Ende
    Institute of Tropical Medicine, Antwerp, Belgium University Hospital Antwerp, Edegem, Belgium
    Trop Med Int Health 5:607-11. 2000
    The extreme presentation of hyperreactive malaria is hyperreactive malarial splenomegaly syndrome (HMS). Some patients present with a less pronounced syndrome...
  17. ncbi Avian hepatitis E virus in an outbreak of hepatitis--splenomegaly syndrome and fatty liver haemorrhage syndrome in two flaxseed-fed layer flocks in Ontario
    A C Agunos
    Department of Pathobiology, Ontario Veterinary College, University of Guelph, Guelph, Ontario, Canada
    Avian Pathol 35:404-12. 2006
    ..had lesions in the liver and spleen, with 44% of those necropsied having changes consistent with hepatitis-splenomegaly syndrome, with lesions ranging from acute periportal lymphoplasmacytic hepatitis to chronic severe ..
  18. ncbi Role of spleen enlargement in cirrhosis with portal hypertension
    M Bolognesi
    Department of Clinical and Experimental Medicine, University of Padua, Italy
    Dig Liver Dis 34:144-50. 2002
    The possible relationships between splenomegaly and portal hypertension have been analysed in patients with cirrhosis...
  19. pmc Splenomegaly in myelofibrosis--new options for therapy and the therapeutic potential of Janus kinase 2 inhibitors
    Jasleen Randhawa
    Medical College of Wisconsin, Milwaukee, WI, USA
    J Hematol Oncol 5:43. 2012
    b>Splenomegaly is a common sign of primary myelofibrosis (PMF), post-polycythemia vera myelofibrosis (post-PV MF), and post-essential thrombocythemia myelofibrosis (post-ET MF) that is associated with bothersome symptoms, which have a ..
  20. ncbi Murine gammaherpesvirus-induced splenomegaly: a critical role for CD4 T cells
    E J Usherwood
    Department of Veterinary Pathology, University of Edinburgh, UK
    J Gen Virol 77:627-30. 1996
    ..In the first 2-3 weeks after infection mice develop a marked splenomegaly, where the spleen cell number increases by 2-3 fold...
  21. ncbi Urothelial cancer producing granulocyte colony-stimulating factor: possible induction of splenomegaly
    Sachi Kitayama
    Department of Urology and Reproductive Medicine, Tokyo Medical and Dental University Graduate School, Tokyo, Japan
    Urology 63:377-8. 2004
  22. ncbi Forest malaria in Chhindwara, Madhya Pradesh, central India: a case study in a tribal community
    Neeru Singh
    Malaria Research Centre, Jabalpur, Madhya Pradesh, India
    Am J Trop Med Hyg 68:602-7. 2003
    ..75 per 1,000 in 2000. Improved access to treatment facilities, combination therapy, and vector control using an effective insecticide appear to be the most promising methods for controlling malaria in this region...
  23. ncbi Radiotherapy for hypersplenism from congestive splenomegaly
    Mu Tai Liu
    Department of Radiation Oncology, Changhua Christian Hospital, Changhua, Taiwan
    Ann Saudi Med 24:198-200. 2004
  24. ncbi Benzo(a)pyrene-induced anemia and splenomegaly in NZB/WF1 mice
    C D Booker
    Virginia Commonwealth University Richmond, Virginia, USA
    Food Chem Toxicol 43:1423-31. 2005
    ..possibly caused by BaP exposure, or chemical-induced hemolysis, perhaps contributed to by erythrocyte fragility inherited from a parent strain, NZB, which spontaneously develops autoimmune hemolytic anemia and subsequent splenomegaly.
  25. pmc Divergent synthetic nucleotide motif recognition pattern: design and development of potent immunomodulatory oligodeoxyribonucleotide agents with distinct cytokine induction profiles
    Ekambar R Kandimalla
    Hybridon, Inc, 345 Vassar Street, Cambridge, MA 02139, USA
    Nucleic Acids Res 31:2393-400. 2003
    ....
  26. pmc Treatment of suspected hyper-reactive malarial splenomegaly (HMS) in pregnancy with mefloquine
    Juthamas Jaroensuk
    Shoklo Malaria Research Unit SMRU, Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Mae Sot, Thailand Mahidol Oxford Tropical Medicine Research Unit MORU, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand Centre for Clinical Vaccinology and Tropical Medicine, Nuffield Department of Clinical Medicine, University of Oxford, Churchill Hospital, Oxford, United Kingdom
    Am J Trop Med Hyg 90:609-11. 2014
    ..There are few data on hyper-reactive malarial splenomegaly, an aberrant immunological response to chronic or recurrent malaria in pregnancy...
  27. pmc Thrombocytopenia and splenomegaly: an unusual presentation of congenital hepatic fibrosis
    Serena Botto Poala
    Clinic of Pediatric Hematology_Oncology, Department of Pediatrics, University of Padova, Padova, Italy
    Orphanet J Rare Dis 5:4. 2010
    ..We describe the first case of CHF presenting in an otherwise healthy child, with thrombocytopenia and splenomegaly as the only manifestations of the disease.
  28. ncbi Low-grade parasitaemias and cold agglutinins in patients with hyper-reactive malarious splenomegaly and acute haemolysis
    J R Torres
    Instituto de Medicina Tropical, Seccion de Enfermedades Infecciosas, Universidad Central de Venezuela, Apartado 47019, Caracas 1041 A, Venezuela
    Ann Trop Med Parasitol 97:125-30. 2003
    A cluster of 16 cases of hyper-reactive malarious splenomegaly (HMS) with severe, acute haemolysis, from an isolated, Venezuelan, Yanomami population, was prospectively investigated...
  29. ncbi A phase 2 trial of combination low-dose thalidomide and prednisone for the treatment of myelofibrosis with myeloid metaplasia
    Ruben A Mesa
    Division of Hematology and Internal Medicine, Mayo Clinic, Rochester, MN 55905, USA
    Blood 101:2534-41. 2003
    ..tolerability, we prospectively treated 21 symptomatic patients (hemoglobin level < 10 g/dL or symptomatic splenomegaly) with MMM with low-dose THAL (50 mg/d) along with a 3-month oral prednisone (PRED) taper (beginning at 0...
  30. doi Efficacy and tolerability of hydroxyurea in the treatment of the hyperproliferative manifestations of myelofibrosis: results in 40 patients
    Alejandra Martínez-Trillos
    Hematology Department, Hospital Clinic, IDIBAPS, University of Barcelona, Barcelona, Spain
    Ann Hematol 89:1233-7. 2010
    ..2 months (range 0-141.7). Reasons for treatment were constitutional symptoms (55%), symptomatic splenomegaly (45%), thrombocytosis (40%), leukocytosis (28%), pruritus (10%), and bone pain (8%)...
  31. ncbi Hyper-reactive malarial splenomegaly
    John L Ziegler
    University of California San Francisco, San Francisco, California 94143 0808, USA
    Am J Trop Med Hyg 78:186-7. 2008
  32. ncbi A case of hyper-reactive malarial splenomegaly. The role of rapid antigen-detecting and PCR-based tests
    B Mothe
    Infectious Diseases Unit, Internal Medicine Department, Hospital de la Santa Creu i Sant Pau, Universitat de Barcelona, Barcelona, Spain
    Infection 36:167-9. 2008
    Hyper-reactive malarial splenomegaly (HMS) - originally referred to as tropical splenomegaly syndrome - is characterized by a massive splenomegaly, high titres of anti-malarial antibodies and polyclonal IgM hypergammaglobulinemia...
  33. pmc Rapamycin reverses splenomegaly and inhibits tumor development in a transgenic model of Epstein-Barr virus-related Burkitt's lymphoma
    Osman Cen
    Department of Microbiology and Immunology, Feinberg School of Medicine, Northwestern University, 303 E Chicago Avenue, Ward 6 241, Chicago, IL 60611, USA
    Mol Cancer Ther 10:679-86. 2011
    ..the PI3K/Akt/mTOR pathway, we tested the therapeutic efficacy of mTOR inhibitor rapamycin on the tumors and splenomegaly in these double transgenic mice (Tg6/λ-MYC)...
  34. ncbi The use of PCR in the diagnosis of hyper-reactive malarial splenomegaly (HMS)
    S Puente
    Servicio de Enfermedades Infecciosas, Hospital Carlos III, Instituto de Salud Carlos III Insalud, Madrid, Spain
    Ann Trop Med Parasitol 94:559-63. 2000
    Between August 1997 and September 1998, 14 cases of hyper-reactive malarial splenomegaly (HMS) were diagnosed in the Instituto de Salud Carlos III in Madrid, Spain...
  35. doi Radiation therapy for palliation of Eisenmenger's syndrome-associated painful splenomegaly
    Jonathan I Osorio
    School of Medicine Medical University of South Carolina, Charleston, SC 29425, USA
    Radiat Med 26:84-7. 2008
    Painful splenomegaly has a clinical presentation that is often associated with myeloproliferative disorders, such as acute or chronic lymphoblastic or myelogenous leukemia...
  36. doi Role of BI-1 (TEGT)-mediated ERK1/2 activation in mitochondria-mediated apoptosis and splenomegaly in BI-1 transgenic mice
    Jung Hyun Kim
    Department of Animal Biotechnology, Konkuk University, Seoul, South Korea
    Biochim Biophys Acta 1823:876-88. 2012
    ..Interestingly, we found that BI-1 TG mice showed splenomegaly and abnormal megakaryopoiesis...
  37. pmc Role for inducible costimulator in control of Salmonella enterica serovar Typhimurium infection in mice
    Mariana Vidric
    Department of Immunology, University of Toronto, 1 King s College Circle, Toronto, Ontario, Canada M5S 1A8
    Infect Immun 74:1050-61. 2006
    ..ICOS-/- mice exhibited greater splenomegaly than WT mice and showed delayed bacterial clearance...
  38. ncbi The morbidity of schistosomiasis mansoni in the Rusizi Plain (Burundi)
    B Gryseels
    Laboratory for Parasitology, State University of Leiden, The Netherlands
    Trans R Soc Trop Med Hyg 82:582-7. 1988
    ..was found in 26% of those infected, and in 10% of those not infected; right lobe hepatomegaly in 7% and 5%, and splenomegaly in 30% and 24%, respectively...
  39. doi Laparoscopic and open splenectomy for splenomegaly secondary to liver cirrhosis: an evaluation of immunity
    Zhong Wu
    Department of Hepatopancreatobiliary Surgery, West China Hospital, Sichuan University, Chengdu, 610041, China
    Surg Endosc 26:3557-64. 2012
    We sought to investigate the perioperative inflammatory response and immunological function of patients with portal hypertension-induced splenomegaly who underwent laparoscopic (LS) or open splenectomy (OS).
  40. doi Validation of PCR for detection and characterization of parasitaemia in massive splenomegaly attributed clinically to malaria infection
    Salwa M E A-Elgayoum
    Department of Zoology, Faculty of Science, University of Khartoum, P O Box 321, Khartoum, Sudan
    Diagn Microbiol Infect Dis 70:207-12. 2011
    In this study, 101 patients with massive splenomegaly (MS) and 41 with moderate splenomegaly (MoS) from Kassala, Eastern Sudan, were included...
  41. doi Radiotherapy of splenomegaly : a palliative treatment option for a benign phenomenon in malignant diseases
    Jan Kriz
    Department of Radiation Oncology, University of Cologne, Cologne, Germany
    Strahlenther Onkol 187:221-4. 2011
    Since the 20(th) century, radiotherapy (RT) has been used for treatment of symptomatic splenomegaly (SM). SM occurs in association with hematologic disorders...
  42. ncbi Hyper-reactive Malarial Splenomegaly (HMS) in malaria endemic area in Eastern Sudan
    Mushal M Allam
    Institute of Endemic Diseases, University of Khartoum, P O Box 102, Khartoum, Sudan
    Acta Trop 105:196-9. 2008
    Hyper-reactive Malarial Splenomegaly (HMS) is massive enlargement of the spleen resulting from abnormal immune response to repeated attacks of malaria...
  43. doi Histopathological and molecular features of persistent polyclonal B-cell lymphocytosis (PPBL) with progressive splenomegaly
    Ilaria del Giudice
    Department of Cellular Biotechnologies and Haematology, Division of Haematology, Sapienza University, Rome, Italy
    Br J Haematol 144:726-31. 2009
    Five cases of persistent polyclonal B-cell lymphocytosis (PPBL) with progressive splenomegaly are reported; three were splenectomized. BCL2/IGH rearrangements were found in three cases; HLA-DRB1*07 in all...
  44. ncbi Is the laparoscopic approach reasonable in cases of splenomegaly?
    Eduardo Ma Targarona
    Service of General and Digestive Surgery, Hospital de Sant Pau, Autonomous University of Barcelona, Barcelona, Spain
    Semin Laparosc Surg 11:185-90. 2004
    Laparoscopic splenectomy in cases of splenomegaly has been shown to be feasible in experienced hands, even though the size of the spleen increases the operative time and difficulty...
  45. doi Splenomegaly in FOLFOX-naïve stage IV or recurrent colorectal cancer patients due to chemotherapy-associated hepatotoxicity can be predicted by the aspartate aminotransferase to platelet ratio before chemotherapy
    Kazuhiro Miura
    Department of Gastroenterological Surgery, St Marianna University Hospital, St Marianna University School of Medicine, 2 16 1 Sugao, Miyamae ku, Kawasaki 216 8511, Japan
    Int J Clin Oncol 16:257-63. 2011
    Chemotherapy-associated hepatotoxicity is a common cause of postoperative complications after major hepatectomy. Splenomegaly may indicate portal hypertension due to chemotherapy...
  46. ncbi Immunostimulatory activity of CpG oligonucleotides containing non-ionic methylphosphonate linkages
    D Yu
    Hybridon Inc, 345 Vassar Street, Cambridge, MA 02139, USA
    Bioorg Med Chem 9:2803-8. 2001
    ..These results have significance in understanding CpG oligonucleotide-receptor interactions and the development of potent immunomodulatory agents...
  47. ncbi Staple line bleeding following laparoscopic splenectomy: intraoperative prevention and postoperative management with splenic artery embolization
    Kent W Kercher
    Department of Surgery, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Surg Laparosc Endosc Percutan Tech 13:353-6. 2003
    ..In this paper we identify and discuss important technical aspects of obtaining hilar vascular control during LS and report the first use of postoperative splenic artery embolization to control staple line bleeding following LS...
  48. doi The AMPKγ1 subunit plays an essential role in erythrocyte membrane elasticity, and its genetic inactivation induces splenomegaly and anemia
    Marc Foretz
    Institut Cochin, Département d Endocrinologie Métabolisme et Cancer, 24 rue du Faubourg St Jacques, 75014 Paris, France
    FASEB J 25:337-47. 2011
    ..Prkag1(-/-) mice displayed splenomegaly and iron accumulation due to compensatory splenic erythropoiesis and erythrophagocytosis...
  49. doi A multicenter retrospective study of childhood brucellosis in Chicago, Illinois from 1986 to 2008
    Latania K Logan
    Rush University Medical Center, 1653 West Congress Parkway, Suite 736 Murdock, Chicago, IL 60612, USA
    Int J Infect Dis 15:e812-7. 2011
    ..To determine risk factors in children for the acquisition of Brucella, clinical presentation, treatment, and disease outcomes...
  50. ncbi [Successful management with partial splenic embolization (PSE) of splenomegaly and thrombocytopenia caused by oxaliplatin-based chemotherapy for advanced colorectal cancer]
    Keiichiro Hiramoto
    Dept of Gastroenterology, Yamagata City Hospital Saiseikan
    Gan To Kagaku Ryoho 38:835-9. 2011
    ..which received chemotherapy, in which partial splenic embolization (PSE) had been effective for controlling splenomegaly and thrombocytopenia. Case 1: A 50-year-old man presented with bloody urine and bloody stool...
  51. pmc Lymphotoxin-alpha-deficient mice can clear a productive infection with murine gammaherpesvirus 68 but fail to develop splenomegaly or lymphocytosis
    B J Lee
    La Jolla Institute for Allergy and Immunology, San Diego, California 92121, USA
    J Virol 74:2786-92. 2000
    ..The virus also induces splenomegaly and an increase in the number of activated CD8 T cells in the circulation...
  52. ncbi Trends in laparoscopic splenectomy for massive splenomegaly
    Sarah W Grahn
    Department of Surgery, University of California, San Francisco, USA
    Arch Surg 141:755-61; discussion 761-2. 2006
    ..During the past 10 years, expertise with minimally invasive techniques has grown, leading to an increase in successful laparoscopic splenectomy (LS) even in the setting of massive and supramassive spleens...
  53. ncbi Analysis of risk factors for massive intraoperative bleeding during laparoscopic splenectomy
    Masayuki Ohta
    First Department of Surgery, Oita University Faculty of Medicine, 1 1 Idaigaoka, Hasama machi, Yufu, Oita, 879 5593, Japan
    J Hepatobiliary Pancreat Surg 12:433-7. 2005
    ..Laparoscopic splenectomy is occasionally converted to open surgery due to massive intraoperative bleeding. The aim of this study was to identify the risk factors for massive bleeding during laparoscopic splenectomy...
  54. doi Low dose palliative radiotherapy for splenomegaly in hematologic disorders
    Konstantin Lavrenkov
    Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel
    Leuk Lymphoma 53:430-4. 2012
    b>Splenomegaly (SM) is a common complication in hematologic disorders often associated with hypersplenism, and may cause pain, epigastric discomfort and variable systemic effects due to cytopenias...
  55. pmc Dasatinib therapy results in decreased B cell proliferation, splenomegaly, and tumor growth in a murine model of lymphoma expressing Myc and Epstein-Barr virus LMP2A
    Jamie L Dargart
    Department of Microbiology Immunology, Northwestern University Feinberg School of Medicine, 303 E Chicago Avenue, Ward 6 245, Chicago, IL, USA
    Antiviral Res 95:49-56. 2012
    ..LMP2A/λ-MYC double transgenic mice develop splenomegaly and cervical lymphomas starting at 8 weeks of age...
  56. doi The feasibility and safety of laparoscopic splenectomy for massive splenomegaly: a comparative study
    Jin Zhou
    Department of Gastrointestinal Surgery, West China Hospital, Sichuan University, Chengdu, Sichuan, China
    J Surg Res 171:e55-60. 2011
    Laparoscopic splenectomy used for massive splenomegaly is still controversial. The purpose of our current study was to identify the feasibility and safety of laparoscopic splenectomy for massive splenomegaly.
  57. doi Adjuvant FOLFOX chemotherapy and splenomegaly in patients with stages II-III colorectal cancer
    Revathi Angitapalli
    Arlington Cancer Center, Arlington, TX, USA
    Oncology 76:363-8. 2009
    ..We conducted a retrospective study to assess the effects of adjuvant FOLFOX chemotherapy on the splenic index (SI) as a surrogate marker for portal hypertension...
  58. ncbi Laparoscopic splenectomy in patients with normal-sized spleens versus splenomegaly: does size matter?
    B T Heniford
    Department of Surgery and Medicine, Carolinas Medical Center, Charlotte, North Carolina 28232, USA
    Am Surg 67:854-7; discussion 857-8. 2001
    ..The application of minimally invasive techniques in the setting of splenomegaly is less well defined and was previously considered a contraindication to the laparoscopic approach...
  59. doi Reappraisal of anterior approach to laparoscopic splenectomy: technical feasibility and its clinical application
    Sung Hoon Choi
    Department of Surgery, Yonsei University College of Medicine, Clinic of Pancreatic and Biliary Cancer, Institute of Gastroenterology, Yonsei University Health System, Seoul, Korea
    Surg Laparosc Endosc Percutan Tech 21:353-7. 2011
    ..The presented technique of modified laparoscopic splenectomy seems to be a feasible, easy, and safe procedure. It is also thought that surgical indication could be extended even to the splenomegaly by this technique.
  60. pmc Hand-assisted laparoscopic splenectomy versus open splenectomy for massive splenomegaly: 20-year experience at a Canadian centre
    Todd W Swanson
    Department of Surgery, University of British Columbia, Vancouver, Canada
    Can J Surg 54:189-93. 2011
    ..Concerns regarding a purely laparoscopic splenectomy for massive splenomegaly (> 20 cm) arise from potentially longer operative times, higher conversion rates and increased blood loss...
  61. ncbi Surgical treatment of massive splenomegaly and severe hypersplenism secondary to extrahepatic portal venous obstruction in children
    Roy Choudhury Subhasis
    Department of Pediatric Surgery, Lady Hardinge Medical College, New Delhi 110001, India
    Surg Today 37:19-23. 2007
    Massive splenomegaly with severe hypersplenism can occur as a late complication of portal hypertension (PH) caused by extrahepatic portal venous obstruction (EHPVO) in children...
  62. ncbi Sickle cell disease and hyperreactive malarial splenomegaly (HMS) in young immigrants from Africa
    Lucia De Franceschi
    Blood 106:4415-7. 2005
  63. doi [Hyperreactive malarial splenomegaly: three clinical cases and literature review]
    B Camara
    Service de Maladies Infectieuses et Tropicales, Hopital Purpan, 1, Place Baylac, 31059 Toulouse, Cedex 9, France
    Med Mal Infect 39:29-35. 2009
    Hyperreactive malarial splenomegaly (HMS) is the chronic stage of a long-term stimulation of the immune system secondary to plasmodial infections, more frequently in genetically predisposed patients...
  64. ncbi [The clinical application of splenectomy in pyrexia of unknown origin with splenomegaly]
    Han Ying Sun
    Department of Hematology, Tongji Hospital, Tongji Medical College, Huazhong Science and Technology University, Wuhan 430030, China
    Zhonghua Nei Ke Za Zhi 44:89-91. 2005
    To observe the clinical value of splenectomy for pathologic diagnosis in fever of unknown origin with splenomegaly only.
  65. ncbi Hyper-reactive malarial splenomegaly in a patient with human immunodeficiency virus
    G De Iaco
    Infectious and Tropical Medicine Institute, University of Brescia, Italy
    Am J Trop Med Hyg 78:239-40. 2008
    Both hyperreactive malarial splenomegaly (HMS) and HIV infection are highly prevalent in sub-Saharan Africa, but the inter-relationships between the two conditions are not clearly defined...
  66. doi Isolated splenic tuberculosis presenting with splenomegaly and pyrexia of unknown origin
    Satyendra K Tiwary
    ANZ J Surg 78:322-3. 2008
  67. ncbi Patients with unusual bladder malignancies and a rare cause of splenomegaly. Case 2. Rhabdomyosarcoma of the urinary bladder in an adult
    Mohammadbagher Ziari
    Department of Hematology and Oncology, Baylor College of Medicine, Houston, TX, USA
    J Clin Oncol 23:4459-60. 2005
  68. ncbi Association of Plasmodium falciparum isolates encoding the p. Falciparum chloroquine resistance transporter gene K76T polymorphism with anemia and splenomegaly, but not with multiple infections
    Inas Z Abdel-Aziz
    Hygiene Institut, Abteilung Parasitologie, Universitatsklinikum Heidelberg, Heidelberg, Germany
    Am J Trop Med Hyg 72:252-5. 2005
    ..regression analysis showed that pfcrt K76T-carrying isolates are significantly more likely to cause anemia and splenomegaly. Furthermore, we found that infections with P...
  69. ncbi The morbidity of schistosomiasis mansoni in the highland focus of Lake Cohoha, Burundi
    B Gryseels
    Project Bilharziose, Ministry of Health Belgian Cooperation Agency, Bujumbura, Burundi
    Trans R Soc Trop Med Hyg 84:542-7. 1990
    ..7%, 2%, and 1%; of left lobe hepatomegaly 30%, 18%, and 9%; of right lobe hepatomegaly 18%, 10%, and 5%; of splenomegaly 18%, 10%, and 7%. Organomegaly was generally mild, even in area A...
  70. ncbi Bacteremia, fever, and splenomegaly caused by a newly recognized bartonella species
    Marina E Eremeeva
    Centers for Disease Control and Prevention, Atlanta, USA
    N Engl J Med 356:2381-7. 2007
    ..We describe a patient who had fever and splenomegaly after traveling to Peru and also had bacteremia from an organism that resembled Bartonella bacilliformis, the ..
  71. doi JAK inhibition with ruxolitinib versus best available therapy for myelofibrosis
    Claire Harrison
    Guy s and St Thomas National Health Service Foundation Trust, Guy s Hospital, London, United Kingdom
    N Engl J Med 366:787-98. 2012
    ..Treatment options for myelofibrosis are limited. We evaluated the efficacy and safety of ruxolitinib, a potent and selective Janus kinase (JAK) 1 and 2 inhibitor, as compared with the best available therapy, in patients with myelofibrosis...
  72. pmc Hepatosplenomegaly is associated with low regulatory and Th2 responses to schistosome antigens in childhood schistosomiasis and malaria coinfection
    Shona Wilson
    Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QP, United Kingdom
    Infect Immun 76:2212-8. 2008
    ....
  73. ncbi Genetic identification and characterization of a novel virus related to human hepatitis E virus from chickens with hepatitis-splenomegaly syndrome in the United States
    G Haqshenas
    Center for Molecular Medicine and Infectious Diseases, Department of Biomedical Sciences and Pathobiology, College of Veterinary Medicine, Virginia Polytechnic Institute and State University, 1410 Price's Fork Road, Blacksburg, VA 24061-0342, USA
    J Gen Virol 82:2449-62. 2001
    Hepatitis-splenomegaly (HS) syndrome is an emerging disease in chickens in North America; the cause of this disease is unknown...
  74. pmc A double-blind, placebo-controlled trial of ruxolitinib for myelofibrosis
    Srdan Verstovsek
    Leukemia Department, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    N Engl J Med 366:799-807. 2012
    ..Ruxolitinib, a selective inhibitor of Janus kinase (JAK) 1 and 2, has clinically significant activity in myelofibrosis...
  75. ncbi AML1 deletion in adult mice causes splenomegaly and lymphomas
    G Putz
    Max Planck Institute for Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, 01307 Dresden, Germany
    Oncogene 25:929-39. 2006
    ..Metastatic lymphomas to the liver and the meninges were observed. Mice also developed splenomegaly with an expansion of the myeloid compartment. Increased Howell-Jolly body counts indicated splenic hypofunction...
  76. ncbi Hepatosplenomegaly in Kenyan schoolchildren: exacerbation by concurrent chronic exposure to malaria and Schistosoma mansoni infection
    Shona Wilson
    Department of Pathology, University of Cambridge, Cambridge, UK
    Trop Med Int Health 12:1442-9. 2007
    ..We investigated the role of chronic malaria in childhood hepatosplenomegaly in the presence and absence of concurrent S. mansoni infection...
  77. doi Combined deficiency of proapoptotic regulators Bim and Fas results in the early onset of systemic autoimmunity
    Jack Hutcheson
    Department of Molecular Microbiology and Immunology, School of Medicine, Saint Louis University, Saint Louis, MO 63104, USA
    Immunity 28:206-17. 2008
    ..These data demonstrate that dysregulation of the Bcl-2 or Fas pathways can alter the function of APCs, thereby leading to SLE pathogenesis...
  78. ncbi Non-invasive predictors of the presence of large oesophageal varices in patients with cirrhosis
    K C Thomopoulos
    Department of Internal Medicine, Division of Gastroenterology University Hospital of Patras, Patras, Greece
    Dig Liver Dis 35:473-8. 2003
    ..The aim of the present study was to determine whether clinical or laboratory non-endoscopic parameters could predict the presence of large oesophageal varices...
  79. pmc Micro-geographical variation in exposure to Schistosoma mansoni and malaria, and exacerbation of splenomegaly in Kenyan school-aged children
    Mark Booth
    Division of Microbiology and Parasitology, Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QP, UK
    BMC Infect Dis 4:13. 2004
    ..They both cause enlargement of the spleen, but their relative contribution to the condition of splenomegaly remains unknown in areas where both infections are endemic...
  80. doi Disruption of the Gardos channel (KCa3.1) in mice causes subtle erythrocyte macrocytosis and progressive splenomegaly
    Ivica Grgic
    Department of Internal Medicine Nephrology, Faculty of Medicine, Philipps University, 35033 Marburg, Germany
    Pflugers Arch 458:291-302. 2009
    ..Deformability to increasing shear stress was unchanged. Strikingly, K(Ca)3.1(-/-)-mice developed progressive splenomegaly which was considerable ( approximately 200% of controls) in the >6-month-old mice and was paralleled by ..
  81. ncbi Association of splenomegaly with cerebral malaria and decreased concentrations of reactive nitrogen intermediates in Thailand
    M Nacher
    Institut National de la Santé et de la Recherche Médicale Unité 511, Immunobiologie Cellulaire et Moleculaire des Infections Parasitaires, Faculté de Médecine Pitié Salpêtrière, Paris, France
    Am J Trop Med Hyg 65:639-43. 2001
    ..In Thailand, malaria transmission is low and splenomegaly is rarer than in high transmission areas...
  82. pmc Inhibition of receptor tyrosine kinases restores immunocompetence and improves immune-dependent chemotherapy against experimental leishmaniasis in mice
    Jane E Dalton
    Centre for Immunology and Infection, Hull York Medical School and Department of Biology, University of York, United Kingdom
    J Clin Invest 120:1204-16. 2010
    ..of the broad-spectrum RTKI sunitinib maleate (Sm) blocked the vascular remodeling and progressive splenomegaly associated with experimental visceral leishmaniasis...
  83. doi Splenomegaly: investigation, diagnosis and management
    Anna L Pozo
    Norfolk and Norwich University Hospital, Norwich, United Kingdom
    Blood Rev 23:105-11. 2009
    b>Splenomegaly is a feature of a broad range of diseases, and presents to clinicians in many fields...
  84. ncbi JAK2 V617F mutational status predicts progression to large splenomegaly and leukemic transformation in primary myelofibrosis
    Giovanni Barosi
    Unit of Clinical Epidemiology and Center for the Study of Myelofibrosis, Istituto di Ricovero e Cura a Carattere Scientifico IRCCS Policlinico S Matteo Foundation, Pavia, Italy
    Blood 110:4030-6. 2007
    ..Adjusting for conventional risk factors, V617F mutation independently predicted the evolution toward large splenomegaly, need of splenectomy, and leukemic transformation...
  85. ncbi Hepatosplenic morbidity in two neighbouring communities in Uganda with high levels of Schistosoma mansoni infection but very different durations of residence
    M Booth
    Dept of Pathology, University of Cambridge, Tennis Court Rd, Cambridge CB2 1QP, UK
    Trans R Soc Trop Med Hyg 98:125-36. 2004
    ..This parameter should therefore be a routine measurement during epidemiological surveys of S. mansoni...
  86. ncbi Laparoscopic splenectomy for massive splenomegaly
    Kent W Kercher
    Department of General Surgery, Carolinas Medical Center, P O Box 32861, Charlotte, NC 28232, USA
    Am J Surg 183:192-6. 2002
    Laparoscopic splenectomy (LS) is the preferred operative approach for diseases involving normal-sized spleens. Our experience with laparoscopic splenectomy in the setting of massive splenomegaly is presented.
  87. pmc Hereditary thrombocytosis caused by MPLSer505Asn is associated with a high thrombotic risk, splenomegaly and progression to bone marrow fibrosis
    Luciana Teofili
    Department of Hematology, Catholic University, Rome, Italy
    Haematologica 95:65-70. 2010
    ..Recently, we detected this mutation in a large proportion of children with familial thrombocythemia, suggesting that in Italy the incidence of MPL(Ser505Asn) mutation could be underestimated...
  88. doi Clinical and laboratory predictors of esophageal varices in children and adolescents with portal hypertension syndrome
    Eleonora Druve Tavares Fagundes
    Department of Pediatrics, Hospital das Clinicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil
    J Pediatr Gastroenterol Nutr 46:178-83. 2008
    ..To determine the clinical and laboratory parameters that may predict the presence of esophageal varices in children and adolescents with portal hypertension...
  89. ncbi Detailed clinical and ultrasound examination of children and adolescents in a Schistosoma mansoni endemic area in Kenya: hepatosplenic disease in the absence of portal fibrosis
    Birgitte J Vennervald
    Danish Bilharziasis Laboratory, Charlottenlund, Denmark
    Trop Med Int Health 9:461-70. 2004
    ..These results indicate that hepatosplenic disease in school-aged children attributable to S. mansoni infection, involving hepatosplenomegaly and increased portal vein diameter, can occur in the absence of peri-portal fibrosis...
  90. pmc Malaria morbidity and immunity among residents of villages with different Plasmodium falciparum transmission intensity in North-Eastern Tanzania
    John P A Lusingu
    National Institute for Medical Research, Amani Medical Research Centre, Amani and NIMR Headquarters, Dar es Salaam, Tanzania
    Malar J 3:26. 2004
    ..The relationship between the burden of uncomplicated malaria and transmission intensity is unclear and a better understanding of this relationship is important for the implementation of intervention programmes...
  91. doi Potent and selective inhibition of polycythemia by the quinoxaline JAK2 inhibitor NVP-BSK805
    Fabienne Baffert
    Disease Area Oncology, Novartis Institutes for BioMedical Research, 4057 Basel, Switzerland
    Mol Cancer Ther 9:1945-55. 2010
    ..The inhibitor was efficacious in suppressing leukemic cell spreading and splenomegaly in a Ba/F3 JAK2(V617F) cell-driven mouse mechanistic model...
  92. ncbi Enhanced splenomegaly and severe liver inflammation in haptoglobin/hemopexin double-null mice after acute hemolysis
    Emanuela Tolosano
    Department of Genetics, Biology and Biochemistry, University of Turin and the San Giovanni Battista Hospital, Turin, Italy
    Blood 100:4201-8. 2002
    ..alteration in phenotype under basal conditions, nonlethal hemolytic stress in these animals led to pronounced splenomegaly as well as liver inflammation and fibrosis...
  93. ncbi Murine mammary carcinoma 4T1 induces a leukemoid reaction with splenomegaly: association with tumor-derived growth factors
    Kenneth W Hunter
    Department of Microbiology and Immunology, University of Nevada School of Medicine, Reno, NV 89557, USA
    Exp Mol Pathol 82:12-24. 2007
    A leukemoid reaction with granulocytosis and splenomegaly has been observed in animals and humans with a variety of tumors...
  94. ncbi Ethnic differences in the prevalence of splenomegaly and malaria in The Gambia
    B M Greenwood
    Medical Research Council Laboratories, Fajara, Banjul, The Gambia
    Ann Trop Med Parasitol 81:345-54. 1987
    Significant variations in the prevalence of splenomegaly were found among members of the three main ethnic groups resident in North Bank Division, The Gambia...
  95. pmc Host genetic control of recovery from Friend leukemia virus-induced splenomegaly: mapping of a gene within the major histocompatability complex
    B Chesebro
    J Exp Med 140:1457-67. 1974
    ..F(1) mice which were H-2(b/b) had a high incidence of recovery from splenomegaly compared to H-2(b/d) or H-2(b/a) mice...
  96. pmc Genetic dissection of lupus pathogenesis: a recipe for nephrophilic autoantibodies
    C Mohan
    Simmon s Arthritis Research Center, Center for Immunology, University of Texas Southwestern Medical School, Dallas 75235 8884, USA
    J Clin Invest 103:1685-95. 1999
    ..NZMc1|c7 mice, bicongenic for Sle1 and Sle3, exhibit splenomegaly, significantly expanded populations of activated B and CD4(+) T cells, and a robust, variegated IgG ..
  97. ncbi Gaucher's disease with Parkinson's disease: clinical and pathological aspects
    B Bembi
    Unità Operativa Dipartimentale di Malattie Metaboliche, I R C C S Burlo Garofolo, Trieste, Italy
    Neurology 61:99-101. 2003
    ..The authors describe four patients (two siblings) with type 1 Gaucher disease presenting with the following signs of typical PD: asymmetric onset of rigidity, resting tremor, bradykinesia, and a favorable response to Parkinson therapies...
  98. pmc Isolated splenomegaly as the presenting feature of Niemann-Pick disease type C
    J Imrie
    Willink Biochemical Genetics Unit, Royal Manchester Children's Hospital, Manchester M27 4HA, UK
    Arch Dis Child 84:427-9. 2001
    ..If the diagnosis is not considered and established, the family are at risk of having further affected children. Investigation of patients with isolated splenomegaly is not complete until NPC has been excluded.
  99. doi Autoimmune disease in Lyn-deficient mice is dependent on an inflammatory environment established by IL-6
    Evelyn Tsantikos
    Signal Transduction Laboratory, Ludwig Institute for Cancer Research, Royal Melbourne Hospital, Victoria, Australia
    J Immunol 184:1348-60. 2010
    ..B cells, are able to produce IL-6, which facilitates hyperactivation of B and T cells, enhanced myelopoiesis, splenomegaly, and, ultimately, generation of pathogenic autoreactive Abs...
  100. doi Relationship between immunoglobulin isotype response to Plasmodium falciparum blood stage antigens and parasitological indexes as well as splenomegaly in sympatric ethnic groups living in Mali
    Manijeh Vafa
    Department of Immunology, Stockholm University, Svante Arrheniusväg 16, S 106 91 Stockholm, Sweden
    Acta Trop 109:12-6. 2009
    ..A positive correlation between elevated levels of anti-malarial IgG and IgG3 and splenomegaly was noted only within the Fulani group...
  101. pmc Innate immune activation during Salmonella infection initiates extramedullary erythropoiesis and splenomegaly
    Amy Jackson
    Center for Infectious Diseases and Microbiology Translational Research, Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, University of Minnesota Medical School, Minneapolis, MN 55455, USA
    J Immunol 185:6198-204. 2010
    Systemic Salmonella infection commonly induces prolonged splenomegaly in murine or human hosts...

Research Grants80

  1. Identification of Genes Involved in beta- Thelassemia
    Stefano Rivella; Fiscal Year: 2005
    ..of the human beta-globin gene interferes with iron metabolism and leads to ineffective erythropoiesis, splenomegaly and osteopenia...
  2. Understand and Improve Iron Distribution and Erythropoiesis in Beta-Thalassemia
    Yelena Ginzburg; Fiscal Year: 2013
    ..Beta-thalassemia in humans is a disease associated with anemia, splenomegaly, and ineffective erythropoiesis;iron overload in this disease results from transfusion and increased iron ..
  3. Functional analysis of Phospholipase D4
    David Nemazee; Fiscal Year: 2010
    ..At three months of age these mice already exhibit evidence of multiorgan inflammation, splenomegaly, possible defects in B cell development and thymic selection, and excess numbers of activated and memory B and ..
  4. Caspase 8: A Novel Suppressor of Dendritic Cell-Mediated Autoimmunity
    Carla M Cuda; Fiscal Year: 2013
    ..CreCD11cCasp8flox/flox mice display splenomegaly, lymphadenopathy, dsDNA-reactive autoantibodies, glomerulonephritis, immune complex deposition in the kidney, ..
  5. Immune and genetic determinants of murine glomerulonephritis
    Elahna Paul; Fiscal Year: 2012
    ..In addition to chronic kidney disease, features of the B6.CD48-/- phenotype include splenomegaly, hypergammaglobulinemia and autoantibody production...
  6. Regulation of Immunity and Inflammation by TIPE2
    Youhai H Chen; Fiscal Year: 2013
    ..develop normally, but suffer from spontaneous inflammatory diseases characterized by multi- organ inflammation, splenomegaly, heightened inflammatory cytokine production and premature death...
  7. Novel Mechanisms of C-Kit Regulation in Mast Cells
    Reuben Kapur; Fiscal Year: 2013
    ..in Tet2 are associated with higher leukocyte counts, monocyte counts, serum tryptase levels, mast cell burden, splenomegaly and the presence of activating KIT mutation, KITD816V...
  8. KALLIKREIN KININ SYSTEM IN INFLAMMATORY BOWEL DISEASE
    Robert Colman; Fiscal Year: 2001
    ..edema, neutrophil infiltration), chronic intestinal inflammation and the systemic complications (arthritis, splenomegaly, hepatomegaly, leukocytosis, and the acute phase reaction...
  9. Genetics of Autoimmune Hemolytic Anemia
    Dwight H Kono; Fiscal Year: 2013
    ..interval congenic mice demonstrated a marked reduction in autoimmune hemolytic anemia (AIHA) and consequent splenomegaly that was not associated with defects in immunoglobulin levels, anti-nuclear antibodies, or B cell activation...
  10. Molecular and Cellular Characterization of Myeloproliferative Disease
    KATHLEEN MIHO SAKAMOTO; Fiscal Year: 2010
    ..These mice develop monocytosis, splenomegaly, and MPD...
  11. Innate Immunity in Experimental Arthritis of Kininogen
    Robert Colman; Fiscal Year: 2007
    ..inflammatory changes (edema, neutrophil infiltration) and prevented arthritis and the systemic complications (splenomegaly, hepatomegaly, leukocytosis and the acute phase reaction) in the PG-APS model...
  12. Targeting the mTOR signaling pathway in Autoimmune Lymphoproliferative Syndrome
    David T Teachey; Fiscal Year: 2011
    ..Many patients with ALPS develop a severe form of the illness with significant lymphadenopathy, splenomegaly, autoimmune disease, and increased risk of malignancy...
  13. Targeting Akt signaling in Autoimmune Lymphoproliferative Syndrome
    David T Teachey; Fiscal Year: 2013
    ..Many patients with ALPS develop a severe form of the illness with significant lymphadenopathy, splenomegaly, autoimmune disease, and increased risk of malignancy...
  14. SPLENIC TOXICITY OF ANILINE
    M Firoze Khan; Fiscal Year: 1999
    ..methemoglobinemia and hemolytic anemia, aniline exposure also results in selective splenic toxicity leading to splenomegaly, hemorrhage, capsular hyperplasia, fibrosis and eventually a variety of sarcomas...
  15. Combination fusion toxin and cytarabine therapy of AML
    ARTHUR FRANKEL; Fiscal Year: 2002
    ..with minimal disease burden (low or absent circulating blasts, <50 percent marrow replacement and no splenomegaly) responded best. No evidence of drug-related myelosuppression or neurotoxicity was observed...
  16. OLIGONUCLEOTIDE INHIBITION OF CELL PROLIFERATION
    Eric Wickstrom; Fiscal Year: 2000
    ..b) Body weight, splenomegaly, cytokines, complement, liver enzymes and complete blood count will be compared to identify the anti-c-myc ..
  17. ROLE OF AUTOREACTIVE T CELLS IN MURINE AIDS
    Mohan Sopori; Fiscal Year: 1993
    ..This infection causes rapid proliferation of lymphoid cells leading to lymphadenopathy, splenomegaly, hypergammaglobulinemia, and followed by profound immunosuppression affecting all aspects of cellular and ..
  18. Top3 Homologues in Lymphocyte Genome Stability and Aging
    ALBERT SHAW; Fiscal Year: 2009
    ..lifespan, aneuploidy in somatic and germ cells, ionizing and UV-B radiation sensitivity, and age-related splenomegaly and autoantibody production...
  19. The Role of Sphingolipids in Inflammatory Bowel Disease
    ASHLEY SNIDER; Fiscal Year: 2009
    ..colitis in bone marrow chimeric mice, and examine parameters of disease: such as weight loss, colon shortening, splenomegaly, histologic markers of disease, blood and tissue SK1 activity, as well as sphingolipid changes...
  20. POSITRON EMISSION TOMOGRAPHY IMAGING IN AIDS
    C Pauza; Fiscal Year: 1999
    ..In these initial studies, FDG/PET showed a clear pathology (splenomegaly with activation) in acutely infected patients without CD4 depletion and distinguished acute infection from both ..
  21. Role of CD45 in Hematopoiesis and Lymphomagenesis
    Michelle Hermiston; Fiscal Year: 2005
    ..These mice develop a profound lymphoproliferative disorder with polyclonal activation of T and B cells, massive splenomegaly, and premature death...
  22. CHEMOKINES IN THE IMMUNE RESPONSE TO A VIRAL INFECTION
    Sally Sarawar; Fiscal Year: 2002
    ..MHV-68 also induces lymph node enlargement, splenomegaly, and mononucleosis in mice, as Epstein Barr virus does in humans...
  23. LEUKEMIA VIRUS PROJECT
    Robert Peters; Fiscal Year: 1993
    ..Mice are evaluated for general health, and specifically examined for splenomegaly and lymphadenopathy, respiratory distress, and signs of neurologic disease...
  24. PARTICULATE CONTRAST AGENTS FOR MRI
    David Stark; Fiscal Year: 1992
    ..cell function by MRI may allow differential diagnosis of splenic lymphoma and the common benign causes of splenomegaly. LD50, iron metabolism, and other indices of potential toxicity will be used to decide which new materials are ..
  25. CELL CYCLE AND APOPTOSIS REGULATION BY NFAT
    Anjana Rao; Fiscal Year: 2006
    ..In Aim 1, the lymphoproliferative phenotype of NFATI-/- mice will be analyzed, asking specifically whether the splenomegaly and lymphadenopathy of NFATI-/- mice are associated with any malignant transformation of lymphocytes and ..
  26. FRIEND VIRUS SUSCEPTIBILITY IN YOUNG AND AGED MICE
    DENEEN STEWART; Fiscal Year: 1993
    ..This will be accomplished by determining the degree of splenomegaly. 2. Examine difference in viral replication and expression of FV in target organsof young and aged mice...
  27. Intracellular Signaling Triggered by Tall-1/BCMA
    Hong Bing Shu; Fiscal Year: 2005
    ..of TALL-1 in mice leads to autoimmune-like manifestations, such as increased number of mature B-cells, splenomegaly, anti-DNA antibodies, and nephritis...
  28. MURINE RETROVIRAL MODEL FOR HIV DRUG EVALUATION
    Thomas Merigan; Fiscal Year: 1992
    ..nodes by 100-1000 fold, as well as serum immunoglobulin levels, B, CD4+, and Macl+ cell proliferation, and splenomegaly and lymphadenopathy...
  29. Apoptosis in myelofibrosis with myeloid metaplasia
    Ruben Mesa; Fiscal Year: 2006
    ..with myeloid metaplasia is a clonal hematopoietic stem cell disorder that results in progressive cytopenias, splenomegaly, blastic transformation, and death. No broadly applicable therapy is available...
  30. SIVSMMPBJ SUPERANTIGEN AND VIRAL PATHOGENICITY
    Zheng Chen; Fiscal Year: 1999
    ..in vitro and induce an acutely lethal disease in macaques characterized, in part, by lymphadenopathy and splenomegaly. These unique properties of this isolate raise the possibility that this virus may indeed encode a superantigen ..
  31. Phospholipid signaling in B Lymphocytes
    ROBERT RICKERT; Fiscal Year: 2009
    ..In addition, we will determine the extent to which Btk, PDK1 and Akt contribute to the splenomegaly/lymphadenopathy and altered B cell differentiation observed in mice lacking Pten in B cells and thus subject to ..
  32. Xenobiotics, Lipid Peroxidation and Autoimmunity
    M Firoze Khan; Fiscal Year: 2006
    ..abstract_text> ..
  33. NIEMANN-PICK DISEASE
    Melissa Wasserstein; Fiscal Year: 2005
    ..In sum, these studies should provide important diagnostic and therapeutic information to improve the outcome of patients diagnosed with NPD. ..
  34. SPLENIC TOXICITY OF ANILINE
    M Firoze Khan; Fiscal Year: 2010
    ..These studies will elucidate the mechanisms of aniline-induced splenic toxicity, and will be important in devising strategies to prevent toxicity, and in risk assessment of aniline and other structurally-related aromatic amines. ..
  35. B Cell Expansion After Dendritic Cell Immunization
    Michael Jordan; Fiscal Year: 2004
    ..My near term career path will involve ongoing basic research and study in order to improve my ultimate scientific productivity. ..
  36. NOS2 and arginase in visceral leishmaniasis
    Peter Melby; Fiscal Year: 2009
    ..These studies in the hamster will fill a knowledge gap by defining mechanisms of disease and immunity that are strikingly different from those of the murine model. ..
  37. HU-UPCI Cancer Education/Career Development Partnership
    Richard Steinman; Fiscal Year: 2006
    ..abstract_text> ..
  38. RNA editing and its inhibition of HIV-1 replication in human macrophage
    Yoshihiko Hoshino; Fiscal Year: 2007
    ..These studies will establish if ADAR1 impacts on viral replication and mutation and will be the basis of further investigation on the impact of drug abuse on the expression of ADAR1. [unreadable] [unreadable] [unreadable]..
  39. Studies of Prosaposin's Physiologic Role
    Gregory Grabowski; Fiscal Year: 2007
    ..These studies have implications for GSL metabolism, and lysosomal storage disease phenotypic expression and therapy. ..
  40. MOUSE MODELS TO STUDY THE ROLE OF TRAF1 AND TRAF2 IN THE ETIOLOGY OF LEUKEMIA
    Juan Zapata; Fiscal Year: 2007
    ..Characterization of the CLL-like lymphoproliferative disorder caused by overexpression of TRAF2DN and Bcl-2 in B cells. [unreadable] [unreadable] [unreadable] [unreadable]..
  41. Dissection of the Anti-tumor Immune Response
    Erik Ranheim; Fiscal Year: 2006
    ..These studies will provide a clearer picture of CD4+ and CD8+ T cell anti-tumor immunity and better direct efforts at tumor immunotherapy in human patients. ..
  42. MENTORED PATIENT ORIENTED HEMATOLOGY RESEARCH TRAINING
    Sujit Sheth; Fiscal Year: 2004
    ..abstract_text> ..
  43. ANTIBODIES IN PATHOGENESIS OF HIV-1 TROMBOCYTOPENIA
    Henrik Ditzel; Fiscal Year: 2003
    ..He will also look for molecular mimicry with foreign Ag's. ..
  44. Hematopoietic Potential of Skeletal Muscle Cells
    Ronald Hoffman; Fiscal Year: 2004
    ..abstract_text> ..
  45. ALLOCHIMERISM FOLLOWING HAPLOIDENTICAL STEM CELL TRANSPL
    Ronald Hoffman; Fiscal Year: 2002
    ..abstract_text> ..
  46. USING NOVEL TNF RECEPTORS TO ENHANCE IMMUNOTHERAPY
    Andrew Weinberg; Fiscal Year: 2002
    ..Manipulating the combination of the 3 TNF-receptor family members in a tumor setting should help attain long-lived tumor immunity for both CD4+ and CD8+ T cells. ..
  47. Eighth Cooley's Anemia Symposium
    Elliott Vichinsky; Fiscal Year: 2005
    ....
  48. ANTIBODIES IN PATHOGENESIS OF AUTOIMMUNE NEUTROPENIA
    Henrik Ditzel; Fiscal Year: 2002
    ..3) Determine the pathogenesis of the cloned antibodies by generating intact human IgG1 antibodies from the cloned Fab fragments and testing for their ability to sensitize neutrophils by promoting ingestion by macrophages in vitro. ..
  49. ZOONOTIC AND XENOZOONOTIC RISKS OF HEPATITIS E VIRUS
    Xiang Jin Meng; Fiscal Year: 2001
    ..abstract_text> ..
  50. Mechanisms of MMP-3 Action in Acute Lung Injury
    James Varani; Fiscal Year: 2005
    ..These studies will provide an overall understanding of the mechanism(s) by which MMP-3 contributes to acute lung injury. ..
  51. VACCINATION OF DOGS TO REDUCE TRANSMISSION OF LEISHMANIA
    Peter Melby; Fiscal Year: 2003
    ..Successful vaccination of dogs in an endemic could reduce both enzootic (among the canine reservoir) and zoonotic (from the canine reservoir to humans) transmission. ..
  52. NOVEL APPROACHES TO IMPROVE AND EXTEND PLATELET STORAGE
    Sherrill Slichter; Fiscal Year: 2001
    ....
  53. MOLECULAR TOOLS TO DEVELOP HAMSTER MODELS OF DISEASE
    Peter Melby; Fiscal Year: 2003
    ..This work will have particular relevance to research traditionally funded through a number of NIH institutes including the NCI, NIAID, NHLBI, NIA, NIAMS, and NIDR. ..
  54. Modulation of Iron Deposition in SCD and Other Hemoglobinopathies
    ELLIOTT P contact VICHINSKY; Fiscal Year: 2010
    ....
  55. Molecular Mechanisms for IL-25-mediated Th2 Responses
    Xiaoxia Li; Fiscal Year: 2010
    ..With this improved understanding comes the potential to develop specific inhibitors of these pathways and perhaps novel therapeutics for the treatment of asthma. ..
  56. Phase 3 stem cell transplant for light chain amyloidosis
    Morie A Gertz; Fiscal Year: 2011
    ..In addition, the analysis of clonal precursor B cells in the periphery and kinetics of amyloid formation of the monoclonal light chain will allow us to define and determine the mechanisms of disease progression and response to therapy. ..
  57. Candidate Gene Analysis in murine Lupus
    Chandra Mohan; Fiscal Year: 2002
    ..Significance: These experiments have the potential to uncover the identity of a lupus susceptibility gene on murine chromosome 4, that potentially impacts B-cell hyperactivity, pathogenic ANA formation. and end-organ disease. ..
  58. FACTORS INFLUENCING STEM CELL AND PLATELET PRODUCTION
    Malcolm Moore; Fiscal Year: 2002
    ..e., adult populations acquiring features of neonatal cells, or whether there is a tendency for "immortalized" cells to undergo neoplastic transformation. ..
  59. DETERMINANTS OF HEPATITIS C & E MORBIDITY IN EGYPT
    George Strickland; Fiscal Year: 2002
    ..abstract_text> ..
  60. Phase II Trial of Thalidomide in Primary Amyloidosis
    Angela Dispenzieri; Fiscal Year: 2002
    ..The ultimate goal of the proposed studies is to improve the prognosis of patient with this fatal disease. ..
  61. SIGIRR A Negative Regulator of Toll-IL-IR Signaling
    Xiaoxia Li; Fiscal Year: 2009
    ..Specifically, the proposed studies should result in significant advances in the field of innate mucosal immunity and should also help us to determine the potential of SIGIRR as a target for developing anti-inflammatory drugs. ..
  62. Act1 in CD40-/BAFFR-Mediated B Cell Survival
    Xiaoxia Li; Fiscal Year: 2009
    ..finding, Act1-deficient mice revealed a general increase in peripheral B cells, culminating in lymphadenopathy, splenomegaly, and the formation of autoantibodies...
  63. MOUSE MODELS TO STUDY MULIBREY NANISM
    Juan Zapata; Fiscal Year: 2005
    ..study the developmental and phenotypic alterations of trim37 knock out and FINmajor-mutated trim37 mice. These mice will be the foundation for further studies on the biology and etiology of Mulibrey Nanism. ..
  64. Lupus locus, Sle3- innate and adaptive immunity
    Chandra Mohan; Fiscal Year: 2005
    ..In particular, biochemical and genetic studies will be carried out to determine if S/e3 might impact the My D88 or TRIF dependent signaling pathways. ..
  65. CpG Plus Rituximab Therapy in Follicular Lymphoma
    Arnold Freedman; Fiscal Year: 2005
    ..This study is a novel approach to treating FL, where augmenting antigen presentation and effector cells may lead to enhanced cytotoxic effects of rituximab and induce anti-tumor immunity. ..
  66. Screen for Mycobacterium Tuberculosis (RMI)
    E White; Fiscal Year: 2005
    ..tuberculosis. 3) To study the effect of these novel inhibitors on the pantothenate pathway in M. smegmatis. 4) To co-crystallize these compounds with pantothenate synthetase to study their mode of binding ..
  67. Molecular Pharmacology of Estrogen Sulfotransferase
    Wenchao Song; Fiscal Year: 2006
    ..The proposed studies will provide a molecular basis for understanding the in vivo pharmacology and physiology of estrogen sulfotransferase as a prototypical phase II steroid sulfoconjugation enzyme. ..
  68. A KINETIC STUDY OF INFLAMMATION-INDUCED HYPORETINEMIA
    Francisco Rosales; Fiscal Year: 2005
    ..In addition, the application of these methods and the development of a model of chronic inflammation will foster research on other micronutrients like iron and zinc that are similarly affected by inflammation. ..
  69. Impact of lupus susceptibility loci on B-cell tolerance
    Chandra Mohan; Fiscal Year: 2007
    ..Understanding how these loci/genes function will not only broaden our perspective of this disease, but will also point to potential targets for therapeutic intervention. ..
  70. Use of Hammerhead Ribozymes in Murine Models of Ol
    Gregory Grabowski; Fiscal Year: 2007
    ....
  71. BRAIN CELL DEATH IN MRL MICE: TARGETS AND MECHANISMS
    Boris Sakic; Fiscal Year: 2004
    ..abstract_text> ..
  72. Graduate Medical Education in Genetics
    Margaret McGovern; Fiscal Year: 2004
    ..abstract_text> ..
  73. ETIOLOGY OF STROKE IN CHILDREN WITH SICKLE CELL DISEASE
    Sherri Zimmerman; Fiscal Year: 2004
    ..Based on this fact-finding study, I will design a hypothesis-driven therapeutic clinical trial for children at highest risk of developing stroke. ..
  74. INBORN ERRORS OF SPHINGOLIPID CATABOLISM
    Gregory Grabowski; Fiscal Year: 2004
    ..abstract_text> ..
  75. A Nucleosomal Biosensor for Identification and Isolation of Nuclear Hormone Recep
    Richard Steinman; Fiscal Year: 2008
    ..This biosensor should be more rapid and versatile than cell-based reporter gene assays and more informative than assays that measure only ligand/receptor binding. [unreadable] [unreadable] [unreadable]..
  76. Mechanism of protection of DAF and CD59 in SLE
    Wenchao Song; Fiscal Year: 2009
    ..Such results should facilitate the development of innovative therapeutic strategies for human SLE. ..
  77. Etanercept Therapy in Follicular Lymphoma
    Arnold Freedman; Fiscal Year: 2003
    ..This study is a novel approach to treating FL, where targeting the microenvironment of the tumor may inhibit the growth and survival of the neoplastic cells. ..
  78. MOLECULAR CONTRIBUTORS TO STEM CELL QUIESCENCE
    Richard Steinman; Fiscal Year: 2003
    ..Insights gained from these studies should have a significant impact on gene therapy strategies and should generate novel tools for the study of leukemias and myelodysplastic syndromes. ..
  79. Cell Cycle Inhibition in Systemic Autoimmunity
    DWIGHT KONO; Fiscal Year: 2009
    ..These studies should yield important new insights into the significance and role of p21 in systemic autoimmunity and in host response to foreign antigens. ..