hepatomegaly

Summary

Summary: Enlargement of the liver.

Top Publications

  1. ncbi A 41-year-old man with fatigue, weight loss, hypercalcemia, and hepatosplenomegaly
    Bruce P Hamilton
    Department of Medicine, University of Maryland School of Medicine, and Medical Care Clinical Center, VA Maryland Health Care System, Baltimore, USA
    Am J Med Sci 324:31-6. 2002
  2. ncbi Xenobiotic stress induces hepatomegaly and liver tumors via the nuclear receptor constitutive androstane receptor
    Wendong Huang
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Mol Endocrinol 19:1646-53. 2005
  3. ncbi Disruption of the sterol 27-hydroxylase gene in mice results in hepatomegaly and hypertriglyceridemia. Reversal by cholic acid feeding
    J J Repa
    Departments of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    J Biol Chem 275:39685-92. 2000
  4. pmc Hepatosplenomegaly is associated with low regulatory and Th2 responses to schistosome antigens in childhood schistosomiasis and malaria coinfection
    Shona Wilson
    Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QP, United Kingdom
    Infect Immun 76:2212-8. 2008
  5. pmc Liver-specific ablation of integrin-linked kinase in mice results in abnormal histology, enhanced cell proliferation, and hepatomegaly
    Vasiliki Gkretsi
    Division of Cellular and Molecular Pathology, Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Hepatology 48:1932-41. 2008
  6. ncbi Hepatosplenomegaly in Kenyan schoolchildren: exacerbation by concurrent chronic exposure to malaria and Schistosoma mansoni infection
    Shona Wilson
    Department of Pathology, University of Cambridge, Cambridge, UK
    Trop Med Int Health 12:1442-9. 2007
  7. ncbi Gaucher's disease with Parkinson's disease: clinical and pathological aspects
    B Bembi
    Unità Operativa Dipartimentale di Malattie Metaboliche, I R C C S Burlo Garofolo, Trieste, Italy
    Neurology 61:99-101. 2003
  8. pmc Liver-specific deletion of negative regulator Pten results in fatty liver and insulin hypersensitivity [corrected]
    Bangyan Stiles
    Department of Molecular and Medical Pharmacology, University of California, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 101:2082-7. 2004
  9. ncbi Regression of hepatosplenomegaly in Kenyan school-aged children after praziquantel treatment and three years of greatly reduced exposure to Schistosoma mansoni
    Birgitte J Vennervald
    Danish Bilharziasis Laboratory, Charlottenlund, Denmark
    Trans R Soc Trop Med Hyg 99:150-60. 2005
  10. ncbi Dietary phospholipid-rich dairy milk extract reduces hepatomegaly, hepatic steatosis and hyperlipidemia in mice fed a high-fat diet
    Elaine Wat
    Nutrition and Metabolism Group, Heart Research Institute, Camperdown, NSW, Sydney, Australia
    Atherosclerosis 205:144-50. 2009

Detail Information

Publications236 found, 100 shown here

  1. ncbi A 41-year-old man with fatigue, weight loss, hypercalcemia, and hepatosplenomegaly
    Bruce P Hamilton
    Department of Medicine, University of Maryland School of Medicine, and Medical Care Clinical Center, VA Maryland Health Care System, Baltimore, USA
    Am J Med Sci 324:31-6. 2002
  2. ncbi Xenobiotic stress induces hepatomegaly and liver tumors via the nuclear receptor constitutive androstane receptor
    Wendong Huang
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Mol Endocrinol 19:1646-53. 2005
    ..Here we show that CAR-mediated hepatomegaly is a transient, adaptive response to acute xenobiotic stress...
  3. ncbi Disruption of the sterol 27-hydroxylase gene in mice results in hepatomegaly and hypertriglyceridemia. Reversal by cholic acid feeding
    J J Repa
    Departments of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    J Biol Chem 275:39685-92. 2000
    ..Cholic acid feeding reverses hepatomegaly and hypertriglyceridemia but not adrenomegaly in Cyp27(-/-) mice...
  4. pmc Hepatosplenomegaly is associated with low regulatory and Th2 responses to schistosome antigens in childhood schistosomiasis and malaria coinfection
    Shona Wilson
    Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QP, United Kingdom
    Infect Immun 76:2212-8. 2008
    ..levels in response to stimulation with SEA were high, and a negative association between presentation with hepatomegaly and the levels of the regulatory cytokines interleukin-6 and transforming growth factor beta(1) suggests that a ..
  5. pmc Liver-specific ablation of integrin-linked kinase in mice results in abnormal histology, enhanced cell proliferation, and hepatomegaly
    Vasiliki Gkretsi
    Division of Cellular and Molecular Pathology, Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Hepatology 48:1932-41. 2008
    ..After the proliferative stage, however, the previous trends are reversed resulting in a super-differentiated phenotype in the ILK-deficient livers...
  6. ncbi Hepatosplenomegaly in Kenyan schoolchildren: exacerbation by concurrent chronic exposure to malaria and Schistosoma mansoni infection
    Shona Wilson
    Department of Pathology, University of Cambridge, Cambridge, UK
    Trop Med Int Health 12:1442-9. 2007
    ..We investigated the role of chronic malaria in childhood hepatosplenomegaly in the presence and absence of concurrent S. mansoni infection...
  7. ncbi Gaucher's disease with Parkinson's disease: clinical and pathological aspects
    B Bembi
    Unità Operativa Dipartimentale di Malattie Metaboliche, I R C C S Burlo Garofolo, Trieste, Italy
    Neurology 61:99-101. 2003
    ..The authors describe four patients (two siblings) with type 1 Gaucher disease presenting with the following signs of typical PD: asymmetric onset of rigidity, resting tremor, bradykinesia, and a favorable response to Parkinson therapies...
  8. pmc Liver-specific deletion of negative regulator Pten results in fatty liver and insulin hypersensitivity [corrected]
    Bangyan Stiles
    Department of Molecular and Medical Pharmacology, University of California, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 101:2082-7. 2004
    ..Deletion of Pten in the liver resulted in increased fatty acid synthesis, accompanied by hepatomegaly and fatty liver phenotype...
  9. ncbi Regression of hepatosplenomegaly in Kenyan school-aged children after praziquantel treatment and three years of greatly reduced exposure to Schistosoma mansoni
    Birgitte J Vennervald
    Danish Bilharziasis Laboratory, Charlottenlund, Denmark
    Trans R Soc Trop Med Hyg 99:150-60. 2005
    ..and mid-clavicular lines decreased monotonically over time, independently of age, whereas clinically measured hepatomegaly along the mid-sternal line and the prevalence of firm livers decreased in an age-specific manner, being more ..
  10. ncbi Dietary phospholipid-rich dairy milk extract reduces hepatomegaly, hepatic steatosis and hyperlipidemia in mice fed a high-fat diet
    Elaine Wat
    Nutrition and Metabolism Group, Heart Research Institute, Camperdown, NSW, Sydney, Australia
    Atherosclerosis 205:144-50. 2009
    ..1 mmol/L vs. 2.6+/-0.1 mmol/L, P<0.01). These data indicate that dietary PLRDME has a beneficial effect on hepatomegaly, hepatic steatosis and elevated serum lipid levels in mice fed a high-fat diet, providing evidence that PLRDME ..
  11. ncbi The morbidity of schistosomiasis mansoni in the Rusizi Plain (Burundi)
    B Gryseels
    Laboratory for Parasitology, State University of Leiden, The Netherlands
    Trans R Soc Trop Med Hyg 82:582-7. 1988
    ..Left lobe hepatomegaly was found in 26% of those infected, and in 10% of those not infected; right lobe hepatomegaly in 7% and 5%, and ..
  12. ncbi Hepatomegaly in transgenic mice expressing the homeobox gene Cux-1
    Gregory B Vanden Heuvel
    Department of Anatomy and Cell Biology, University of Kansas Medical Center, Kansas City, 66160, USA
    Mol Carcinog 43:18-30. 2005
    ..Here we show that mice constitutively expressing Cux-1 exhibit hepatomegaly correlating with an increase in cell proliferation...
  13. ncbi Association of hepatomegaly and jaundice with acute renal failure but not with cerebral malaria in severe falciparum malaria in Thailand
    M Nacher
    Unité INSERM 511, Immunobiologie Cellulaire et Moleculaire des Infections Parasitaires, Faculté de Médecine Pitié Salpêtrière, Paris, France
    Am J Trop Med Hyg 65:828-33. 2001
    ..Jaundice and hepatomegaly were significantly associated with renal failure (adjusted odds ratio [AOR], 3...
  14. ncbi Development of an updated PBPK model for trichloroethylene and metabolites in mice, and its application to discern the role of oxidative metabolism in TCE-induced hepatomegaly
    M V Evans
    National Center for Environmental Assessment, Office of Research and Development, US Environmental Protection Agency, Washington, DC 20460, USA
    Toxicol Appl Pharmacol 236:329-40. 2009
    ..Increases in liver weight (hepatomegaly) have been reported to occur quickly in rodents after TCE exposure, with liver tumor induction reported in mice ..
  15. pmc Aflatoxin exposure may contribute to chronic hepatomegaly in Kenyan school children
    Yun Yun Gong
    Division of Epidemiology, Leeds Institute for Genetics, Health and Therapeutics, University of Leeds, Leeds, United Kingdom
    Environ Health Perspect 120:893-6. 2012
    Presentation with a firm type of chronic hepatomegaly of multifactorial etiology is common among school-age children in sub-Saharan Africa.
  16. ncbi Hepatocyte proliferation and hepatomegaly induced by phenobarbital and 1,4-bis [2-(3,5-dichloropyridyloxy)] benzene is suppressed in hepatocyte-targeted glypican 3 transgenic mice
    Chih Wen Lin
    Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    Hepatology 54:620-30. 2011
    ..This study investigates the role of GPC3 in hepatocyte proliferation and hepatomegaly induced by the xenobiotic mitogens phenobarbital (PB) and TCPOBOP (1, 4-bis [2-(3, 5-dichloropyridyloxy)] ..
  17. ncbi The effects of artemether-lumefantrine vs amodiaquine-sulfalene-pyrimethamine on the hepatomegaly associated with Plasmodium falciparum malaria in children
    A Sowunmi
    Department of Pharmacology and Therapeutics and Institute for Medical Research and Training, University of Ibadan, Ibadan, Nigeria
    Parasitol Res 100:511-7. 2007
    ..In 79 children, the hepatomegaly reduction ratios (HRR) and the speed of resolution of hepatomegaly, the hepatomegaly resolution rates (HRSR), ..
  18. ncbi Trichloroacetic acid: updated estimates of its bioavailability and its contribution to trichloroethylene-induced mouse hepatomegaly
    Weihsueh A Chiu
    National Center for Environmental Assessment, U S Environmental Protection Agency, Washington, DC 20460, USA
    Toxicology 285:114-25. 2011
    ..TCA) is a common drinking water disinfection byproduct that produces a spectrum of liver effects, including hepatomegaly and liver tumors, in mice...
  19. ncbi Accuracy and reliability of palpation and percussion for detecting hepatomegaly: a rural hospital-based study
    Rajnish Joshi
    Division of Epidemiology, University of California at Berkeley, Berkeley, CA 94720, USA
    Indian J Gastroenterol 23:171-4. 2004
    Palpation and percussion are standard bedside techniques used to diagnose hepatomegaly. Ultrasonography is a noninvasive and accurate method for measurement of liver size, but many patients in developing countries have limited access to ..
  20. pmc Prolonged hepatomegaly in mice that cannot inactivate bacterial endotoxin
    Baomei Shao
    Infectious Diseases Division, Department of Internal Medicine, University of Texas Southwestern Medical School, Dallas, TX, USA
    Hepatology 54:1051-62. 2011
    Transient hepatomegaly often accompanies acute bacterial infections. Reversible, dose-dependent hepatomegaly also occurs when animals are given intravenous infusions of bacterial lipopolysaccharide (LPS)...
  21. ncbi A multicenter retrospective study of childhood brucellosis in Chicago, Illinois from 1986 to 2008
    Latania K Logan
    Rush University Medical Center, 1653 West Congress Parkway, Suite 736 Murdock, Chicago, IL 60612, USA
    Int J Infect Dis 15:e812-7. 2011
    ..To determine risk factors in children for the acquisition of Brucella, clinical presentation, treatment, and disease outcomes...
  22. ncbi Hepatosplenic morbidity in two neighbouring communities in Uganda with high levels of Schistosoma mansoni infection but very different durations of residence
    M Booth
    Dept of Pathology, University of Cambridge, Tennis Court Rd, Cambridge CB2 1QP, UK
    Trans R Soc Trop Med Hyg 98:125-36. 2004
    ..This parameter should therefore be a routine measurement during epidemiological surveys of S. mansoni...
  23. pmc Exposure to malaria affects the regression of hepatosplenomegaly after treatment for Schistosoma mansoni infection in Kenyan children
    Mark Booth
    Division of Microbiology and Parasitology, Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QP, UK
    BMC Med 2:36. 2004
    ..The present analysis focused on the possibility that exposure to malaria infection may have limited the resolution of hepatosplenomegaly in a cohort of Kenyan schoolchildren...
  24. ncbi Responses of the liver to perfluorinated fatty acids with different carbon chain length in male and female mice:in relation to induction of hepatomegaly, peroxisomal beta-oxidation and microsomal 1-acylglycerophosphocholine acyltransferase
    Naomi Kudo
    Faculty of Pharmaceutical Sciences, Josai University, Sakado, Saitama, Japan
    Biol Pharm Bull 29:1952-7. 2006
    The potency of the induction of hepatomegaly, peroxisomal beta-oxidation and microsomal 1-acylglycerophoshocholine (1-acyl-GPC) acyltransferase was compared among perfluorinated fatty acids (PFCAs) with 6-9 carbon chain length in the ..
  25. ncbi Hepatic Akt activation induces marked hypoglycemia, hepatomegaly, and hypertriglyceridemia with sterol regulatory element binding protein involvement
    Hiraku Ono
    Institute for Adult Diseases, Asahi Life Foundation, Shinjuku ku, Tokyo, Japan
    Diabetes 52:2905-13. 2003
    ..resulted in a markedly hypoglycemic, hypoinsulinemic, and hypertriglyceridemic phenotype with fatty liver and hepatomegaly. To elucidate the sterol regulatory element binding protein (SREBP)-1c contribution to these phenotypic ..
  26. ncbi Hepatomegaly in transgenic mice expressing an oncogenic form of beta-catenin
    A Cadoret
    Institut Cochin de Génétique Moléculaire INSERM U129, 75014 Paris, France
    Cancer Res 61:3245-9. 2001
    ..These mice rapidly developed hepatomegaly soon after birth, with livers three to four times heavier than those of nontransgenic littermates...
  27. pmc The use of beta-adrenergic blockade in preventing trauma-induced hepatomegaly
    Robert E Barrow
    Department of Surgery, University of Texas Medical Branch, and Shriners Hospitals for Children, Galveston, TX 77550, USA
    Ann Surg 243:115-20. 2006
    The objective of this study was to test the hypothesis that hepatomegaly in burned children can be attenuated or reversed by blocking lipolysis and reducing free fatty acids delivered to the liver.
  28. pmc Transient hyperinsulinism associated with macrosomia, hypertrophic obstructive cardiomyopathy, hepatomegaly, and nephromegaly
    A Mehta
    Great Ormond Street Hospital and The Institute of Child Health, London, UK
    Arch Dis Child 88:822-4. 2003
  29. ncbi Gene associated with seizures, autism, and hepatomegaly in an Amish girl
    Christopher Jackman
    Department of Neurology, Indiana University School of Medicine, Indianapolis, Indiana, USA
    Pediatr Neurol 40:310-3. 2009
    ..This patient exhibited the additional features of periventricular leukomalacia and hepatomegaly.
  30. ncbi Protective effects of vitamin A and vitamin E succinate against 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-induced body wasting, hepatomegaly, thymic atrophy, production of reactive oxygen species and DNA damage in C57BL/6J mice
    Naser Z Alsharif
    Creighton University Medical Center, School of Pharmacy and Health Professions, Department of Pharmacy Sciences, Omaha, NE 68178, USA
    Basic Clin Pharmacol Toxicol 95:131-8. 2004
    ..05). The results indicate a potential role for oxidative stress in the acute toxicity of TCDD and a protective effect for vitamin A and vitamin E succinate in the overall toxicity of TCDD including measures of oxidative stress...
  31. pmc Hepatosplenomegaly associated with chronic malaria exposure: evidence for a pro-inflammatory mechanism exacerbated by schistosomiasis
    S Wilson
    Department of Pathology, University of Cambridge, Cambridge, UK
    Parasite Immunol 31:64-71. 2009
    ..mansoni infected children, compared to those without detectable S. mansoni and malarial infections, but exposed to malaria, suggest that S. mansoni infection may augment the underlying inflammatory reaction...
  32. ncbi Congenital Rosai-Dorfman disease presenting with anemia, thrombocytopenia, and hepatomegaly
    C P Chow
    Department of Paediatrics and Adolescent Medicine, Queen Mary Hospital, Hong Kong, China
    Pediatr Blood Cancer 52:415-7. 2009
    ..We describe a neonate with RDD who presented with anemia, thrombocytopenia and hepatomegaly. He recovered spontaneously with conservative management. This represents an atypical presentation of RDD...
  33. ncbi Clinical characteristics and disposition kinetics of the hepatomegaly associated with acute, uncomplicated, Plasmodium falciparum malaria in children
    A Sowunmi
    Department of Pharmacology and Therapeutics and Postgraduate Institute for Medical Research and Training, University of Ibadan, Nigeria
    Ann Trop Med Parasitol 95:7-18. 2001
    The clinical characteristics and the kinetics of the disposition of the hepatomegaly associated with acute, uncomplicated Plasmodium falciparum malaria were investigated in 162 children in an endemic area of Nigeria...
  34. pmc Liver-specific ablation of integrin-linked kinase in mice results in enhanced and prolonged cell proliferation and hepatomegaly after phenobarbital administration
    Shashikiran Donthamsetty
    Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    Toxicol Sci 113:358-66. 2010
    ..Lack of ILK in the hepatocytes imparts prolonged proliferative response not only to stimuli related to liver regeneration but also to xenobiotic chemical mitogens, such as PB...
  35. ncbi Schistosoma mansoni-related morbidity on Ukerewe Island, Tanzania: clinical, ultrasonographical and biochemical parameters
    R Kardorff
    Children s Hospital, Medizinische Hochschule, Hannover, Germany
    Trop Med Int Health 2:230-9. 1997
    ..Pretreated individuals excreted significantly fewer ova (median 124 vs 192e.p.g., P < 0.001). Hepatomegaly (determined by ultrasonography) was present in 35%, splenomegaly in 80%...
  36. ncbi Activation of Wnt/beta-catenin pathway during hepatocyte growth factor-induced hepatomegaly in mice
    Udayan Apte
    Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15216, USA
    Hepatology 44:992-1002. 2006
    ..It is also known that delivery of the human HGF gene cloned in a plasmid under a CMV promoter results in hepatomegaly in mice. In addition, recently characterized beta-catenin transgenic mice also showed hepatomegaly...
  37. pmc Excessive hepatomegaly of mice with hepatocyte-targeted elimination of integrin linked kinase following treatment with 1,4-bis [2-(3,5-dichaloropyridyloxy)] benzene
    Shashikiran Donthamsetty
    Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    Hepatology 53:587-95. 2011
    ..benzene) an agonist of the constitutive androstane receptor (CAR), produces rapid hepatocyte hyperplasia and hepatomegaly in the absence of hepatic injury...
  38. ncbi Identification of factors contributing to hepatomegaly in severely burned children
    Robert E Barrow
    Shriners Hospitals for Children, Galveston, Texas 77550, USA
    Shock 24:523-8. 2005
    b>Hepatomegaly is a common postmortem observation in severely burned children, with the liver often tripling in size when compared with normal livers for age, weight, and sex...
  39. ncbi Prenatal diagnosis of congenital leukemia in a fetus at 25 weeks' gestation with Down syndrome: case report and review of the literature
    M Robertson
    Department of Obstetrics and Gynecology, University of Stellenbosch, South Africa
    Ultrasound Obstet Gynecol 21:486-9. 2003
    ..A review of the literature of the seven cases described antenatally and 10 cases described in the immediate neonatal period or on examination of the stillborn baby is presented...
  40. ncbi Detailed clinical and ultrasound examination of children and adolescents in a Schistosoma mansoni endemic area in Kenya: hepatosplenic disease in the absence of portal fibrosis
    Birgitte J Vennervald
    Danish Bilharziasis Laboratory, Charlottenlund, Denmark
    Trop Med Int Health 9:461-70. 2004
    ..A case-only study of 96 children aged 7-20 years defined by ultrasound detectable hepatomegaly was undertaken in Makueni district, Kenya...
  41. pmc Micro-geographical variation in exposure to Schistosoma mansoni and malaria, and exacerbation of splenomegaly in Kenyan school-aged children
    Mark Booth
    Division of Microbiology and Parasitology, Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QP, UK
    BMC Infect Dis 4:13. 2004
    ..Here, we have investigated whether relatively high exposure to both infections has a clinically measurable effect on this condition...
  42. ncbi Associations between anti-Schistosoma mansoni and anti-Plasmodium falciparum antibody responses and hepatosplenomegaly, in Kenyan schoolchildren
    Joseph K Mwatha
    Kenya Medical Research Institute, Kenyan Ministry of Health, Nairobi, Kenya
    J Infect Dis 187:1337-41. 2003
    ..falciparum antibodies, compared with nonhepatosplenic children, a finding that strongly suggests that some experience of P. falciparum influenced the development of hepatosplenomegaly in these S. mansoni-infected children...
  43. ncbi Prenatal diagnosis of a transient myeloproliferative disorder in trisomy 21
    A A Baschat
    Department of Obstetrics and Gynaecology, Medical University Lubeck, Germany
    Prenat Diagn 18:731-6. 1998
    ..This may be due to increased vulnerability of the fetus or represent a disease mechanism unique to fetuses with chromosomal abnormalities...
  44. ncbi Four cases of fetal hypoechoic hepatomegaly associated with Trisomy 21 and transient abnormal myelopoiesis
    Akira Kikuchi
    Department of Obstetrics and Gynecology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    Prenat Diagn 27:665-9. 2007
    Our objective was to determine the clinical significance of fetal hypoechoic hepatomegaly and serial change of liver sizes.
  45. ncbi Hypoechoic hepatomegaly associated with transient abnormal myelopoiesis provides clues to trisomy 21 in the third-trimester fetus
    H Hamada
    Department of Obstetrics and Gynecology, Institute of Clinical Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan
    Ultrasound Obstet Gynecol 17:442-4. 2001
    We present two cases of transient abnormal myelopoiesis associated with trisomy 21 that had hypoechoic hepatomegaly during the late fetal period...
  46. ncbi Fetal hydrops and hepatosplenomegaly in the second half of pregnancy: a sign of myeloproliferative disorder in fetuses with trisomy 21
    J M Smrcek
    Division of Prenatal Medicine, Department of Obstetrics and Gynaecology, Medical University of Lubeck, Ratzeburger Allee 160, 23538 Lubeck, Germany
    Ultrasound Obstet Gynecol 17:403-9. 2001
    ..To demonstrate the relationship between fetal hydrops and/or hepatosplenomegaly in the second half of pregnancy with a myeloproliferative disorder in fetuses with trisomy 21 or mosaic trisomy 21...
  47. ncbi Prenatal sonographic findings and hematological abnormalities in fetuses with transient abnormal myelopoiesis with Down syndrome
    Satoshi Hojo
    Department of Obstetrics and Gynecology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Prenat Diagn 27:507-11. 2007
    ..To determine relevant prenatal findings of transient abnormal myelopoiesis (TAM) that have important prognostic implications...
  48. ncbi Hepatic glycogenosis: a rare cause of hepatomegaly in Type 1 diabetes mellitus
    Ayhan Abaci
    Division of Pediatric Endocrinology, Department of Pediatrics, Faculty of Medicine, Dokuz Eylul University, 35340 Inciralti Izmir, Turkey
    J Diabetes Complications 22:325-8. 2008
    b>Hepatomegaly, with or without abnormal liver function tests, was a common feature of both pediatric and adult patients with diabetes mellitus...
  49. ncbi Glycogenic hepatopathy: an underrecognized hepatic complication of diabetes mellitus
    Michael Torbenson
    Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
    Am J Surg Pathol 30:508-13. 2006
    ..All had type I diabetes mellitus with poor glycemic control. The clinical presentations included hepatomegaly, abdominal pain, and elevated transaminases (range, 50-1600 IU/L)...
  50. ncbi The morbidity of schistosomiasis mansoni in the highland focus of Lake Cohoha, Burundi
    B Gryseels
    Project Bilharziose, Ministry of Health Belgian Cooperation Agency, Bujumbura, Burundi
    Trans R Soc Trop Med Hyg 84:542-7. 1990
    ..36%, 25%, and 19%, respectively; of abdominal pain 86%, 78%, and 83%; of fatigue 7%, 2%, and 1%; of left lobe hepatomegaly 30%, 18%, and 9%; of right lobe hepatomegaly 18%, 10%, and 5%; of splenomegaly 18%, 10%, and 7%...
  51. ncbi Diffuse liver metastasis of small cell lung cancer causing marked hepatomegaly and fulminant hepatic failure
    Hisamitsu Miyaaki
    Department of Gastroenterology and Hepatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
    Intern Med 49:1383-6. 2010
    ..Plain CT and MRI of the abdomen showed marked hepatomegaly but no visible nodular lesion in the liver...
  52. ncbi Repeated inhalation exposure to octamethylcyclotetrasiloxane produces hepatomegaly, transient hepatic hyperplasia, and sustained hypertrophy in female Fischer 344 rats in a manner similar to phenobarbital
    J M McKim
    Dow Corning Corporation, 2200 W. Salzburg Road, Midland, Michigan 48686-0994, USA
    Toxicol Appl Pharmacol 172:83-92. 2001
    ..The extent to which these processes are involved with D4-induced hepatomegaly is not known...
  53. pmc Epidermal growth factor receptor: a novel target of the Wnt/beta-catenin pathway in liver
    Xinping Tan
    Department of Pathology, University of Pittsburgh, School of Medicine, Pennsylvania 15261, USA
    Gastroenterology 129:285-302. 2005
    ..Wnt/beta-catenin activation is observed in normal liver development, regeneration, and liver cancer. Our aim was to elucidate the regulation and mechanism of this pathway in liver...
  54. ncbi Mukitake mushroom (Panellus serotinus) alleviates nonalcoholic fatty liver disease through the suppression of monocyte chemoattractant protein 1 production in db/db mice
    Koji Nagao
    Department of Applied Biochemistry and Food Science, Saga University, Saga, Japan
    J Nutr Biochem 21:418-23. 2010
    ..After 4 weeks of feeding, hepatomegaly, hepatic triglyceride accumulation and elevated hepatic injury markers in serum were markedly alleviated in ..
  55. ncbi Hepatic glycogenosis: reversible hepatomegaly in type 1 diabetes
    C F Munns
    Department of Endocrinology, Royal Children s Hospital, Herston, Queensland, Australia
    J Paediatr Child Health 36:449-52. 2000
    ..To describe the aetiology, clinical features and appropriate treatment for hepatic glycogenosis in poorly controlled type 1 diabetes...
  56. pmc Health implications of chronic hepatosplenomegaly in Kenyan school-aged children chronically exposed to malarial infections and Schistosoma mansoni
    Shona Wilson
    Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QP, UK
    Trans R Soc Trop Med Hyg 104:110-6. 2010
    ..This study shows that hepatosplenomegaly associated with chronic exposure to malaria and schistosomiasis is not a benign symptom amongst school-aged children but has potential long-term health consequences...
  57. ncbi Unique management of stage 4S neuroblastoma complicated by massive hepatomegaly: case report and review of the literature
    Stephen Roberts
    Department of Pediatrics, Tripler Army Medical Center, Hawaii, USA
    J Pediatr Hematol Oncol 24:142-4. 2002
    ..A 2-month-old with 4S neuroblastoma complicated by massive hepatomegaly, managed by abdominal decompression surgery and a negative-pressure dressing system is presented...
  58. ncbi Rapid onset of glycogen storage hepatomegaly in a type-2 diabetic patient after a massive dose of long-acting insulin and large doses of glucose
    Tatsuhiro Tsujimoto
    Third Department of Internal Medicine, Nara Medical University, Kashihara
    Intern Med 45:469-73. 2006
    We present a case of rapid onset of glycogen storage hepatomegaly, caused by a massive dose of long-acting insulin and large doses of glucose, in a type-2 diabetic patient...
  59. ncbi Chronic peroxisome proliferation and hepatomegaly associated with the hepatocellular tumorigenesis of di(2-ethylhexyl)phthalate and the effects of recovery
    R M David
    Eastman Kodak Company, Rochester, New York 14652 6272, USA
    Toxicol Sci 50:195-205. 1999
    ..The data indicate that high levels of peroxisome proliferation and hepatomegaly are associated with DEHP hepatocarcinogenesis in rodent liver, and that the tumorigenic process may be arrested ..
  60. ncbi Intermittent and recurrent hepatomegaly due to glycogen storage in a patient with type 1 diabetes: genetic analysis of the liver glycogen phosphorylase gene (PYGL)
    Masako Tomihira
    Division of Endocrinology and Metabolism, St Mary s Hospital, 422 Tsubukuhonmachi, Kurume, Fukuoka, Japan
    Diabetes Res Clin Pract 65:175-82. 2004
    ..During her infantile period she presented with no hepatomegaly nor growth retardation. On admission she was diagnosed with diabetic ketoacidosis (DKA)...
  61. ncbi Two-dimensional electrophoresis of liver proteins: characterization of a drug-induced hepatomegaly in rats
    S J Newsholme
    SmithKline Beecham Pharmaceuticals, King of Prussia, PA 19406, USA
    Electrophoresis 21:2122-8. 2000
    ....
  62. ncbi Radiation therapy for symptomatic hepatomegaly in myelofibrosis with myeloid metaplasia
    A Tefferi
    Division of Hematology and Internal Medicine and Mayo Clinic and Mayo Foundation, Rochester, Minnesota 55905, USA
    Eur J Haematol 66:37-42. 2001
    ..treated with a total of 25 courses of liver, abdominal, or abdominal and pelvic irradiation for symptomatic hepatomegaly with (5 patients) or without (9 patients) ascites...
  63. ncbi Fatty liver
    Michael E D Allison
    Department of Medicine, Addenbrooke s Hospital, Cambridge
    Hosp Med 65:609-12. 2004
    ..This article describes fatty liver and its clinical presentation. The current understanding of processes underlying fatty liver is reviewed, as well as the evidence for therapeutic options...
  64. ncbi [Abnormal liver function in Mediterranean spotted fever]
    Anna Micalizzi
    Cattedra di Medicina Interna e Divisione di Malattie Infettive, Dipartimento di Patologia Clinica e delle Patologie Emergenti, Universita di Palermo, Italy
    Infez Med 15:105-10. 2007
    ..0001). At ultrasound half of the patients showed hepatomegaly with a hepatitis-like pattern and 39% of patients had splenomegaly...
  65. ncbi Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 28-2004. Newborn twins with thrombocytopenia, coagulation defects, and hepatosplenomegaly
    Jeffrey M Lipton
    Department of Pediatrics, Albert Einstein College of Medicine, Bronx, NY, USA
    N Engl J Med 351:1120-30. 2004
  66. ncbi Griscelli syndrome
    Sanjeev Rath
    Division of Pediatric Hematology and Oncology, Advanced Pediatric Centre, Postgraduate Institute of Medical Education and Research, Chandigarh, India
    Indian J Pediatr 71:173-5. 2004
    ..A literature search revealed that Griscelli syndrome (GS) has overlapping symptoms and signs. The findings in skin and hair biopsies in Griscelli syndrome are distinctive...
  67. ncbi Hemophagocytic lymphohistiocytosis in children: abdominal US findings within 1 week of presentation
    Matthias H Schmidt
    Department of Diagnostic Radiology, Dalhousie University, IWK Health Centre, 5850 5980 University Ave, Halifax, NS, Canada B3J 3G9
    Radiology 230:685-9. 2004
    ..To evaluate the ultrasonographic (US) findings at presentation in a series of children who received a diagnosis of hemophagocytic lymphohistiocytosis (HLH) at a single institution...
  68. ncbi Anterior pituitary hormone effects on hepatic functions in infants with congenital hypopituitarism
    Wikrom Karnsakul
    Department of Pediatrics, Section of Gastroenterology and Nutrition, West Virginia University School of Medicine, Morgantown, WV 26506 9214, USA
    Ann Hepatol 6:97-103. 2007
    ..Congenital hypopituitarism is an uncommon cause of neonatal cholestasis. Little is known about the effect of anterior pituitary hormone on hepatic functions...
  69. ncbi Pancytopenia, a rare hematologic manifestation of brucellosis in children
    Musa Karakukcu
    Department of Pediatric Hematology Oncology, Erciyes University Faculty of Medicine, 38039 Kayseri, Turkey
    J Pediatr Hematol Oncol 26:803-6. 2004
    ..All children recovered completely; the pancytopenia was transient and resolved after the antibiotic treatment of Brucella infection. Brucellosis should be considered as a possible diagnosis among patients with pancytopenia...
  70. ncbi Clinical and laboratory aspects of malaria among children with fever in a low transmission area of Sudan
    E M Malik
    National Malaria Control Programme, Khartoum, Sudan
    East Mediterr Health J 11:753-61. 2005
    ..Further investment is needed to improve microscopic diagnosis facilities in local hospitals to overcome the problem of over-diagnosis of malaria...
  71. ncbi Uncomplicated malaria
    M P Grobusch
    Infectious Diseases Unit, Faculty of Health Sciences, University of the Witwatersrand, 7 York Road Parktown, 2196 Johannesburg, South Africa
    Curr Top Microbiol Immunol 295:83-104. 2005
    ..Children with a high level of exposure to P. falciparum have a lower risk of developing atopic disorders...
  72. ncbi The clinical and demographic characteristics of nonneuronopathic Gaucher disease in 887 children at diagnosis
    Paige Kaplan
    Section of Metabolic Diseases, Department of Pediatrics, The Children s Hospital of Philadelphia, 34th and Civic Center Boulevard, Philadelphia, PA 19104, USA
    Arch Pediatr Adolesc Med 160:603-8. 2006
    ..To describe the clinical and demographic characteristics of nonneuronopathic Gaucher disease (GD) in children at the time of diagnosis...
  73. pmc Macrophage activation syndrome in a child with systemic juvenile rheumatoid arthritis
    Mina Hur
    Department of Laboratory Medicine, Hallym University College of Medicine, Seoul, Korea
    J Korean Med Sci 20:695-8. 2005
    ..This is the third case of MAS associated with S-JRA in Koreans, and the first one, in which hemophagocytic macrophages were proven in bone marrow...
  74. ncbi Prolonged severe pancytopenia preceding the cutaneous lesions of juvenile xanthogranuloma
    Takuya Hara
    Department of Pediatrics, Graduate School of Medical Sciences, Kyushu University, Maidashi, Fukuoka, Japan
    Pediatr Blood Cancer 47:103-6. 2006
    ..Although JXG is a benign non-Langerhans cell histiocytosis, the multisystem-visceral form should be considered as a potential aggressive disease when associated with BM failure in early infancy...
  75. ncbi [Adult-onset Still disease. 11 cases]
    Siham Goumri
    Service de Medecine Interne, CHU Ibn Rochd, Casablanca
    Tunis Med 84:443-9. 2006
    ..9%) which 2 erosive forms. Adenopathies were present in 5 patients, a splenomegaly and a hepatomegaly were noticed respectively in 4 and 2 cases...
  76. ncbi An autopsied case of a 10-month-old baby with hepatosplenomegaly, high fever and necrotizing encephalopathy
    Nobutaka Arai
    Department of Clinical Neuropathology, Tokyo Metropolitan Institute for Neuroscience, 2 6 Musashidai, Fuchu, Tokyo 183 8526, Japan
    Neuropathology 26:498-500. 2006
  77. ncbi Ocular findings in a patient with hemophagocytic syndrome
    Edward W Lee
    Department of Ophthalmology and Visual Science, University of Chicago, 5841 S Maryland, MC 2114, Chicago, IL 60637, USA
    Arch Ophthalmol 124:1656-8. 2006
  78. ncbi Syngenic bone marrow cells restore hepatic function in carbon tetrachloride-induced mouse liver injury
    Yun Jae Jung
    Department of Microbiology, Ewha Woman s University College of Medicine, Ewha Medical Research Center, Seoul, Korea
    Stem Cells Dev 15:687-95. 2006
    ..SDF-1/CXCR-4 interaction plays a role in stem cell homing toward the damaged organ, and transplanted BMCs are involved in the up-regulated SDF-1 expression seen in the injured liver...
  79. ncbi Evaluation of hepatic function with (99m)Tc-galactosylated serum albumin scintigraphy in patients with malaria: comparison with (99m)Tc-colloid scintigraphy and liver ultrasonography
    Sang Woo Lee
    Department of Nuclear Medicine, Kyungpook National University Hospital, Daegu, Korea
    Nucl Med Commun 28:95-9. 2007
    Malarial parasites injected by the mosquito rapidly target hepatocytes, and hepatomegaly is commonly observed during the progress of the disease in malaria patients...
  80. ncbi Clinical quiz. Gamma-Gandy bodies
    Mukadder Ayse Selimoglu
    Departments of Pediatric Gastroenterology, Ataturk University, Faculty of Medicine, Erzurum, Turkey
    J Pediatr Gastroenterol Nutr 40:524-5. 2005
  81. ncbi [Cholesterol ester storage disease]
    Marlon Fernández-Aragón
    Servicio de Gastroenterología y Nutrición, Instituto Nacional de Pediatria, Mexico
    Rev Gastroenterol Mex 69:171-5. 2004
    The goal of this paper is to present a clinical case of a 4 year old boy, with hepatomegaly, splenomegaly and intestinal lipid infiltration due to a inborn error of lipid metabolism known as cholesterol ester storage disease...
  82. pmc Schistosomiasis mansoni: novel chemotherapy using a cysteine protease inhibitor
    Maha Hamadien Abdulla
    Sandler Center for Basic Research in Parasitic Diseases, California Institute for Quantitative Biomedical Research, University of California San Francisco, San Francisco, California, United States of America
    PLoS Med 4:e14. 2007
    ..Due to the lack of a vaccine, patient therapy is heavily reliant on chemotherapy with praziquantel as the World Health Organization-recommended drug, but concerns over drug resistance encourage the search for new drug leads...
  83. ncbi Peripheral blood and marrow findings in disseminated bacille Calmette-Guerin infection
    Perikala Vijayananda Kumar
    Department of Pathology, Shiraz Medical School, Shiraz, Iran
    J Pediatr Hematol Oncol 27:97-9. 2005
    ..These findings have not been previously reported in the literature...
  84. ncbi [Disseminated Mycobacterium chelonae infection during HIV. ]
    R Fernandez-Rodriguez
    Service de Medecine Interne, Hôpital Cristal Chou, Rua do Paseo 30, 3o E post, Ourense, Spain
    Presse Med 33:1439-40. 2004
    ..An atypical mycobacterium, Mycobacterium chelonae is a saprophyte germ in the environment, but rarely pathogenic. A few disseminated infections can be noted in immunodepressed patients...
  85. ncbi A host lipase detoxifies bacterial lipopolysaccharides in the liver and spleen
    Baomei Shao
    Department of Internal Medicine, University of Texas Southwestern Medical School, Dallas, Texas 75390 9113, USA
    J Biol Chem 282:13726-35. 2007
    ..Providing recombinant AOAH restored LPS deacylating ability to Aoah(-/-) mice and prevented LPS-induced hepatomegaly. AOAH-mediated deacylation is a previously unappreciated mechanism that prevents prolonged inflammatory ..
  86. ncbi Adult T-cell leukemia presenting with acute liver failure
    Nicholas Powell
    Liver Unit, Queen Elizabeth Hospital, University Hospital Birmingham NHS Trust, Edgbaston, Birmingham, UK
    Leuk Res 30:1315-7. 2006
    ..Liver histology revealed massive infiltration with atypical lymphocytes typical of ATL and liver necrosis...
  87. ncbi Byler disease. Fatal familial intrahepatic cholestasis in an Amish kindred
    R J Clayton
    Am J Dis Child 117:112-24. 1969
  88. ncbi Heart, liver and spleen pathology in chronic alcohol and drug users
    Junie Li Chun Wong
    Division of Pathology Forensic Medicine, University of Edinburgh, Teviot Place, Edinburgh EH8 9AG, Scotland, UK
    J Forensic Leg Med 15:141-7. 2008
    ..Alcohol misuse was associated with cardiomegaly (27% vs. 19%, male CA vs. control) and hepatomegaly (38% vs. 15%). Majority of cases had only one organ affected...
  89. ncbi Mesenteric mass in a young girl--an unusual site for Gaucher's disease
    Adrian K P Lim
    Department of Radiology, Great Ormond Street Hospital for Children, London, UK
    Pediatr Radiol 32:674-6. 2002
    ..The radiologist and clinician should be alert to the possible development of these new problems and the fact that in Gaucher's disease a palpable right upper-quadrant mass need not necessarily represent hepatomegaly.
  90. ncbi Inflammatory pseudotumor of lymph nodes presenting as pyrexia of unknown origin
    H Gulwani
    Department of Histopathology, Sir Ganga Ram Hospital, New Delhi, India
    Indian J Pathol Microbiol 51:67-9. 2008
    ..It is thus not only important to be aware of this rare benign pathologic entity while dealing with a case of lymphadenopathy, but also consider it in the differential diagnosis of granulomatous disease...
  91. ncbi Overlapping functions of lysosomal acid phosphatase (LAP) and tartrate-resistant acid phosphatase (Acp5) revealed by doubly deficient mice
    A Suter
    Zentrum Biochemie und Molekulare Zellbiologie, Abt Biochemie II, Universitat Gottingen, Heinrich Düker Weg 12, 37073 Gottingen, Germany
    Development 128:4899-910. 2001
    ..We conclude that for several substrates LAP and Acp5 can substitute for each other and that these acid phosphatases are essential for processing of non-collagenous proteins, including osteopontin, by osteoclasts...
  92. ncbi A boy with fever, lymphadenopathy, hepatosplenomegaly, and lymphocytosis
    Ujwala Kaza
    Section of Allergy and Immunology, Louisiana State University Health Sciences Center, Shreveport, LA 71130 3832, USA
    Allergy Asthma Proc 29:216-20. 2008
    ..Autopsy revealed the presence of EBV in the brain, indicating the ineffectiveness of rituximab therapy in treating central nervous system infection with EBV...
  93. ncbi Outcomes of Schistosoma mansoni infection in outbred albino mice exposed to Larvin contaminant
    A M Attallah
    Research and Development Department, Biotechnology Research Center, New Damietta City, Egypt
    Parasitol Res 103:567-76. 2008
    ..Oral administration of 1/5 and 1/10 LD(50) of Larvin to S. mansoni-exposed mice induced (1) hepatomegaly and splenomegaly; (2) prominent lymphocytic aggregation in liver replacing large areas of bridging necrosis; (3)..
  94. doi An infant with fever, hepatosplenomegaly, and pancytopenia
    Yaseen Rafee
    Division of Infectious Diseases, Children s Hospital of Michigan, Wayne State University, 3901 Beaubien Blvd, Detroit, MI 48201, USA
    Pediatr Infect Dis J 27:571. 2008
  95. doi A 67-year-old male with hypercalcemia and an unrevealing splenectomy
    Giuseppe Famularo
    Department of Internal Medicine, San Camillo Hospital, Rome, Italy
    Am J Hematol 83:739-43. 2008
  96. ncbi Non-cirrhotic portal fibrosis in a patient with rheumatoid arthritis
    G Makharia
    Department of Hepatology, Postgraduate Institute of Medical Education and Research, Chandigarh
    Indian J Gastroenterol 20:197-8. 2001
    ..There are reports of the association of idiopathic portal hypertension, a condition similar to NCPF, with progressive systemic sclerosis, Hashimoto's thyroiditis and systemic lupus erythematosus...
  97. pmc Congenital monoblastic leukemia with 9;11 translocation in monozygotic twins : a case report
    S Y Park
    Department of Pathology, Seoul National University College of Medicine, Seoul, Korea
    J Korean Med Sci 16:366-70. 2001
    ..Cytogenetic study revealed 9;11 translocation, which is frequently associated with acute monoblastic leukemia. To the best of our knowledge, this is the first report of congenital monoblastic leukemia of monozygotic twins in Korea...
  98. ncbi [Neurological form of onset in haemophagocytic lymphohistiocytosis]
    M C García-Koerner
    Servei de Neurologia Unid Integr Pediatr Hospital Universitario Sant Joan de Deu, Esplugues de Llobregat, 08950, Espana
    Rev Neurol 32:333-5. 2001
    ....
  99. ncbi Lysosomal acid lipase-deficient mice: depletion of white and brown fat, severe hepatosplenomegaly, and shortened life span
    H Du
    Division of Human Genetics, Children s Hospital Research Foundation, Cincinnati, OH 45229, USA
    J Lipid Res 42:489-500. 2001
    ..The involvement of macrophages throughout the body of lal-/- mice provide evidence for a critical nonappreciated role of LAL in cellular cholesterol and fatty acid metabolism, adipocyte differentiation, and fat mobilization...
  100. ncbi Gamma/delta T cell lymphoma
    Akihiko Taguchi
    Division of Hematology, Department of Medicine, Yamaguchi Prefecture Central Hospital, Hofu 747 8511
    Intern Med 43:120-5. 2004
    ....
  101. ncbi A new variant neuropathic type of Gaucher's disease characterized by hydrocephalus, corneal opacities, deformed toes, and fibrous thickening of spleen and liver capsules
    K Inui
    Department of Pediatrics, Faculty of Medicine, Osaka University, Osaka, Japan
    J Pediatr 138:137-9. 2001
    ..Enzyme replacement therapy was given for 4 years, resulting in an improvement of visceral and hematologic abnormalities but no neurologic improvement...

Research Grants39

  1. Iron-Induced Changes in Liver That Predispose to Malignancy
    Harriet C Isom; Fiscal Year: 2010
    ..Iron overload, using TMHF as an iron donor, induced cyclin D1 expression, PCNA labeling index and hepatomegaly confirming similar findings in mice in which different iron donors were used to generate iron overload...
  2. Role of Lipoproteins in Chagasic heart disease
    JYOTHI FALGUNI NAGAJYOTHI; Fiscal Year: 2013
    ..Acute infection caused myocarditis, hepatomegaly, lipolysis, impaired serum lipid levels, and elevated tissue/organ cholesterol...
  3. Rescuing Niemann-Pick C Disease: Pathways of Liver and Brain Degeneration
    Matthew P Scott; Fiscal Year: 2013
    ..NPC patients suffer from hepatomegaly and progressive cognitive and locomotion losses, with massive Purkinje neuron (PN) death in the cerebellum...
  4. KALLIKREIN KININ SYSTEM IN INFLAMMATORY BOWEL DISEASE
    Robert Colman; Fiscal Year: 2001
    ..infiltration), chronic intestinal inflammation and the systemic complications (arthritis, splenomegaly, hepatomegaly, leukocytosis, and the acute phase reaction...
  5. Molecular basis for skeletal muscle pathophysiology in Pompe's disease
    Jeffrey E Pessin; Fiscal Year: 2013
    ..In addition, the classical infantile-onset form results in hepatomegaly due to increased glycogen deposition within the liver...
  6. Innate Immunity in Experimental Arthritis of Kininogen
    Robert Colman; Fiscal Year: 2007
    ..changes (edema, neutrophil infiltration) and prevented arthritis and the systemic complications (splenomegaly, hepatomegaly, leukocytosis and the acute phase reaction) in the PG-APS model...
  7. HIF dependent pathways and acetylation events in alcohol mediated liver injury
    BHARATH DWARAKA NATH; Fiscal Year: 2010
    ..recently described transgenic mouse model of liver-specific HIF activation demonstrates lipid accumulation and hepatomegaly, lending more credence to earlier observations that hypoxia may have a mechanistic relationship to alcoholic ..
  8. PEROXISOME PROLIFERATORS AND THE CELL CYCLE
    JANE ISHMAEL; Fiscal Year: 2002
    ..alterations in response to treatment with peroxisome proliferators, such as peroxisome proliferation, hepatomegaly, increased DNA synthesis, increased expression of PPAR-alpha regulated genes and hepatocarcinogenesis...
  9. MOUSE MODELS TO STUDY MULIBREY NANISM
    Juan Zapata; Fiscal Year: 2005
    ..onset, hypoplasia of several endocrine glands with consequent hormonal deficiency, constrictive pericardium, hepatomegaly, hydrocephaloid skull, muscle hypotonia and susceptibility to develop ovarian and Wilm's tumors...
  10. Melanocortin-3 receptor regulation of insulin action
    Andrew Butler; Fiscal Year: 2005
    ..Moreover, obese MC3RKO do not develop some of the pathologies normally associated with obesity: hepatomegaly, elevated free fatty acids, increased liver fatty acid synthase mRNA expression, and reduced liver IRS2 protein...
  11. Patterns of gene expression in Mulibrey Nanism
    Juan Zapata; Fiscal Year: 2005
    ..Severe growth failure of prenatal onset, constrictive pericardium with consequent hepatomegaly, hypoplasia of several endocrine glands with consequent hormonal deficiency, fibrosis of different organs, ..
  12. HEPATOCYTE VOLUME CONTROL AND ALCOHOLIC INJURY
    Robert Wondergem; Fiscal Year: 1993
    ..are to elucidate the failure of hepatocyte volume regulation during chronic ethanol ingestion, which results in hepatomegaly. Liver enlargement in turn leads to portal hypertension, impaired microcirculation, and anoxic degeneration of ..
  13. Phase 3 stem cell transplant for light chain amyloidosis
    Morie A Gertz; Fiscal Year: 2011
    ..In addition, the analysis of clonal precursor B cells in the periphery and kinetics of amyloid formation of the monoclonal light chain will allow us to define and determine the mechanisms of disease progression and response to therapy. ..
  14. Role of ATM in Radiosensitivity of Gliomas
    Chandan Guha; Fiscal Year: 2004
    ..IV) To investigate the combined toxicity of the virus vectors, ATM attenuation and radiation therapy in cultured endothelial cells, astrocytes, oligodendrocytes, neurons and brain tissues in mice models. ..
  15. 10th International KSHV and Related Agents Workshop
    Scott Wong; Fiscal Year: 2007
    ..The conference will include an opening day welcome reception, a second day poster session reception, an excursion on the third day and a banquet on the fourth day of the Workshop. [unreadable] [unreadable] [unreadable] [unreadable]..
  16. MARROW REGULATION IN CYCLIC HEMATOPOIESIS
    David Dale; Fiscal Year: 2003
    ....
  17. Epigenetic toxicity of polycyclic aromatic hydrocarbons
    Brad Upham; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  18. Cell Signaling, PXR Phosphorylation & Drug Disposition
    Jeffrey Staudinger; Fiscal Year: 2009
    ..These studies will provide additional insight into the regulation of drug disposition and drug-drug interaction. ..
  19. Preparative irradiation for hepatocyte transplantation
    Chandan Guha; Fiscal Year: 2009
    ..In specific aim 2B, will test whether compensatory regenerative stimuli, provided by methotrexate + HIR-induced liver necrosis, can be used as a substitute to PH. ..
  20. Metabolomic and Toxicogenetic Study of Ethanol Toxicity
    Ivan Rusyn; Fiscal Year: 2009
    ..abstract_text> ..
  21. NEUROPLASTICITY OF BRAIN ASPHYXIATED INFANTS
    Meena Garg; Fiscal Year: 2003
    ....
  22. HIV MUCOSAL PATHOGENESIS IN PRIMARY INFECTION
    Michael Poles; Fiscal Year: 2003
    ..abstract_text> ..
  23. NMR STUDIES:HEPATIC GLUCOSE METABOL IN HUMANS EXERCISING
    Kitt Petersen; Fiscal Year: 2003
    ..The results of these studies should provide important new insight into the regulation of hepatic glucose metabolism in healthy and type 1 diabetic subjects. ..
  24. MITOCHONDRIAL DNA ANALYSIS IN CYCLIC VOMITING SYNDROME
    Richard Boles; Fiscal Year: 2002
    ..An extensive amount of clinical and laboratory data will be collected in all patients, allowing for the comparison of CVS sufferers with and without mtDNA mutations. ..
  25. Validating VIL-6 as a target for KSHV-associated disease
    Scott Wong; Fiscal Year: 2005
    ..The results should help elucidate the role of the vlL-6 in virus infection and provide new insights into the future development of diagnostics and therapies for gamma-2 herpesvirus-induced malignancies. ..
  26. Molecular mechanisms of pancreatic fibrogenesis
    Brent Neuschwander Tetri; Fiscal Year: 2007
    ..Accomplishing these aims will fill significant gaps in the understanding of chronic pancreatitis and this new knowledge may help identify effective treatment approaches to this disease. [unreadable] [unreadable]..
  27. EVALUATING USE OF GENETIC INFORMATION: A MODEL PROCESS
    Wylie Burke; Fiscal Year: 2003
    ..5. To conduct an evaluation of the model process within a large health care system. ..
  28. DNA REPAIR AND SUSCEPTIBILITY TO ENVIRONMENTAL AGENTS
    Ivan Rusyn; Fiscal Year: 2004
    ..These experiments will also provide crucial mechanistic insights into possible differences in species- and tissue-specific responses to DNA damage induced by environmental agents. ..
  29. NIEMANN-PICK DISEASE
    Melissa Wasserstein; Fiscal Year: 2005
    ..In sum, these studies should provide important diagnostic and therapeutic information to improve the outcome of patients diagnosed with NPD. ..
  30. MOLECULAR RECLASSIFICATION OF PROSTATIC CANCER
    George Michalopoulos; Fiscal Year: 2004
    ..abstract_text> ..
  31. Apoptosis in myelofibrosis with myeloid metaplasia
    Ruben Mesa; Fiscal Year: 2006
    ..abstract_text> ..
  32. Defibrotide for the treatment of severe hepatic veno-cc*
    Paul Richardson; Fiscal Year: 2007
    ..Abstract Not Provided ..
  33. Molecular Mechanisms of Phthalate-induced Carcinogenesis
    Ivan Rusyn; Fiscal Year: 2007
    ..This results in a "potentiation" of a non-specific mitogen release from Kupffer cells activated by lipid-like peroxisome proliferator particles, thus accounting for a characteristic burst of proliferation in the liver. ..
  34. ACCESS OF BLACK PATIENTS TO LIVER TRANSPLANTATION
    Andrea Reid; Fiscal Year: 2004
    ..Advanced-level coursework in clinical epidemiology, biostatistics, survey development, and outcomes will also be a critical element of this project. ..
  35. Perfluorooctane sulfonate (PFOS) Affects Immunity through PPAR-alpha.
    Margie Peden Adams; Fiscal Year: 2007
    ..The unimmunized and immunized experiments will be conducted to control for possible differences in response related to lymphocyte activation from the immunization. [unreadable] [unreadable] [unreadable]..
  36. Insulin Resistance and ABCA1 Transporter Function
    WILLIAM GARVER; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  37. Occult Hepatitis B
    Michael Torbenson; Fiscal Year: 2007
    ..abstract_text> ..
  38. Graduate Medical Education in Genetics
    Margaret McGovern; Fiscal Year: 2004
    ..abstract_text> ..