Genomes and Genes
Summary: General increase in bulk of a part or organ due to CELL ENLARGEMENT and accumulation of FLUIDS AND SECRETIONS, not due to tumor formation, nor to an increase in the number of cells (HYPERPLASIA).
Articles from Journal RESEARCH
Articles from Journal RESEARCH1
Publications342 found, 100 shown here
- Regulation of skeletal muscle mass in mice by a new TGF-beta superfamily memberA C McPherron
Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
Nature 387:83-90. 1997..of wild-type animals, and the increase in mass appears to result from a combination of muscle cell hyperplasia and hypertrophy. These results suggest that GDF-8 functions specifically as a negative regulator of skeletal muscle growth.
- A signature pattern of stress-responsive microRNAs that can evoke cardiac hypertrophy and heart failureEva van Rooij
Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9148, USA
Proc Natl Acad Sci U S A 103:18255-60. 2006..miRNAs) in modulation of cellular phenotypes, we searched for miRNAs that were regulated during cardiac hypertrophy and heart failure...
- A PGC-1α isoform induced by resistance training regulates skeletal muscle hypertrophyJorge L Ruas
Department of Cell Biology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
Cell 151:1319-31. 2012..muscle many of the best known adaptations to endurance-type exercise but has no effects on muscle strength or hypertrophy. We have identified a form of PGC-1α (PGC-1α4) that results from alternative promoter usage and splicing of ..
- Mutations in myostatin (GDF8) in double-muscled Belgian Blue and Piedmontese cattleR Kambadur
AgResearch, Ruakura, Hamilton, New Zealand
Genome Res 7:910-6. 1997A visibly distinct muscular hypertrophy (mh), commonly known as double muscling, occurs with high frequency in the Belgian Blue and Piedmontese cattle breeds...
- Myostatin mutation associated with gross muscle hypertrophy in a childMarkus Schuelke
Department of Neuropediatrics, Charite, University Medical Center Berlin, Berlin, Germany
N Engl J Med 350:2682-8. 2004
- Signaling in muscle atrophy and hypertrophyMarco Sandri
Department of Biomedical Sciences, University of Padova, Padova, Italy
Physiology (Bethesda) 23:160-70. 2008..Understanding the signaling that regulates muscle mass may provide potential therapeutic targets for the prevention and treatment of muscle wasting in metabolic and neuromuscular diseases...
- Effective fiber hypertrophy in satellite cell-depleted skeletal muscleJohn J McCarthy
Department of Physiology, College of Medicine, University of Kentucky, Lexington, KY 40536, USA
Development 138:3657-66. 2011..unresolved question in skeletal muscle plasticity is whether satellite cells are necessary for muscle fiber hypertrophy. To address this issue, a novel mouse strain (Pax7-DTA) was created which enabled the conditional ablation of &..
- Interleukin-6 is an essential regulator of satellite cell-mediated skeletal muscle hypertrophyAntonio L Serrano
Program on Differentiation and Cancer, Center for Genomic Regulation CRG and Center for Neurodegenerative Diseases CIBERNED, Pompeu Fabra University, Barcelona, Spain
Cell Metab 7:33-44. 2008..produced by growing myofibers and associated satellite cells, and genetic loss of IL-6 blunted muscle hypertrophy in vivo...
- Localized Igf-1 transgene expression sustains hypertrophy and regeneration in senescent skeletal muscleA Musaro
Cardiovascular Research Center, Massachusetts General Hospital East, Charlestown, Massachusetts, USA
Nat Genet 27:195-200. 2001..We have generated a model of persistent, functional myocyte hypertrophy using a tissue-restricted transgene encoding a locally acting isoform of insulin-like growth factor-1 that is ..
- MicroRNA-1 negatively regulates expression of the hypertrophy-associated calmodulin and Mef2a genesSadakatsu Ikeda
Department of Cardiology, Children s Hospital Boston, Department of Genetics, Harvard Medical School, Boston, Massachusetts 021151, USA
Mol Cell Biol 29:2193-204. 2009..Consistent with the downregulation of these hypertrophy-associated genes, miR-1 attenuated cardiomyocyte hypertrophy in cultured neonatal rat cardiomyocytes and in the ..
- Histone deacetylase 4 controls chondrocyte hypertrophy during skeletogenesisRick B Vega
Department of Molecular Biology, University of Texas Southwestern Medical Center, 6000 Harry Hines Boulevard, Dallas, TX 75390, USA
Cell 119:555-66. 2004..We showed previously that HDAC9 acts as a negative regulator of cardiomyocyte hypertrophy and skeletal muscle differentiation...
- The muscle fiber type-fiber size paradox: hypertrophy or oxidative metabolism?T van Wessel
Research Institute MOVE, Faculty of Human Movement Sciences, VU University Amsterdam, Van der Boechorststraat 9, 1081 BT, Amsterdam, The Netherlands
Eur J Appl Physiol 110:665-94. 2010..relationship implies that muscle fibers, which are triggered to simultaneously increase their mass/strength (hypertrophy) and fatigue resistance (oxidative capacity), increase these properties (strength or fatigue resistance) to a ..
- Inhibition of FoxO transcriptional activity prevents muscle fiber atrophy during cachexia and induces hypertrophySarah A Reed
Department of Physical Therapy, 101 S Newell Dr, University of Florida, Gainesville, FL 32611, USA
FASEB J 26:987-1000. 2012..decreased myostatin expression, increased MyoD expression and satellite cell proliferation, and induced fiber hypertrophy, which required de novo protein synthesis...
- Chondrocyte hypertrophy and osteoarthritis: role in initiation and progression of cartilage degeneration?P M van der Kraan
Department of Rheumatology, Radboud University, Medical Centre, Geert Grooteplein 28, 6525 Nijmegen, The Netherlands
Osteoarthritis Cartilage 20:223-32. 2012To review the literature on the role and regulation of chondrocyte terminal differentiation (hypertrophy-like changes) in osteoarthritis (OA) and to integrate this in a conceptual model of primary OA development.
- Deep RNA sequencing reveals novel cardiac transcriptomic signatures for physiological and pathological hypertrophyHong Ki Song
School of Life Sciences and Systems Biology Research Center, Gwangju Institute of Science and Technology GIST, Gwangju, Republic of Korea
PLoS ONE 7:e35552. 2012Although both physiological hypertrophy (PHH) and pathological hypertrophy (PAH) of the heart have similar morphological appearances, only PAH leads to fatal heart failure...
- The novel angiotensin II type 1 receptor (AT1R)-associated protein ATRAP downregulates AT1R and ameliorates cardiomyocyte hypertrophyYutaka Tanaka
Department of Medical Science and Cardiorenal Medicine, Yokohama City University Graduate School of Medicine, 3 9 Fukuura, Kanazawa Ku, Yokohama 236 0004, Japan
FEBS Lett 579:1579-86. 2005..of angiotensin II (Ang II) type 1 receptor (AT1R) signaling is reported to play an important role in cardiac hypertrophy. We previously cloned a novel molecule interacting with the AT1R, which we named ATRAP (for Ang II type 1 ..
- MiR-30-regulated autophagy mediates angiotensin II-induced myocardial hypertrophyWei Pan
Cardiovascular Department, the Second Hospital Affiliated to Guangzhou Medical University, Guangzhou Institute of Cardiovascular Disease, Guangzhou, Guangdong Province, China
PLoS ONE 8:e53950. 2013..Role of autophagy and the diagnostic potential of microRNAs that regulate the autophagy in cardiac hypertrophy have not been evaluated...
- Airway smooth muscle hypertrophy and hyperplasia in asthmaAlan L James
Department of Pulmonary Physiology and Sleep Medicine West Australian Sleep Disorders Research Institute, Level 5, G Block, Sir Charles Gairdner Hospital, Hospital Avenue, Nedlands, Western Australia 6009, Australia
Am J Respir Crit Care Med 185:1058-64. 2012Increased thickness of the airway smooth muscle (ASM) layer in asthma may result from hyperplasia or hypertrophy of muscle cells or increased extracellular matrix (ECM).
- CaM kinase II selectively signals to histone deacetylase 4 during cardiomyocyte hypertrophyJohannes Backs
Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9148, USA
J Clin Invest 116:1853-64. 2006..These findings reveal a central role for HDAC4 in CaMKII signaling pathways and have implications for the control of gene expression by calcium signaling in a variety of cell types...
- Expression of microRNAs is dynamically regulated during cardiomyocyte hypertrophyMariko Tatsuguchi
Carolina Cardiovascular Biology Center, University of North Carolina, Chapel Hill, NC 27599, USA
J Mol Cell Cardiol 42:1137-41. 2007..Here, we investigate the involvement of miRNAs in cardiac hypertrophy. We analyzed the global expression of miRNAs in agonist-induced hypertrophic cardiomyocytes as well as in ..
- Hypertrophy and/or Hyperplasia: Dynamics of Adipose Tissue GrowthJunghyo Jo
Laboratory of Biological Modeling, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethedsa, Maryland, USA
PLoS Comput Biol 5:e1000324. 2009Adipose tissue grows by two mechanisms: hyperplasia (cell number increase) and hypertrophy (cell size increase). Genetics and diet affect the relative contributions of these two mechanisms to the growth of adipose tissue in obesity...
- Smad2 and 3 transcription factors control muscle mass in adulthoodRoberta Sartori
Venetian Institute of Molecular Medicine, 35129 Padova, Italy
Am J Physiol Cell Physiol 296:C1248-57. 2009..Furthermore, Smad2/3 inhibition promotes muscle hypertrophy independent of satellite cells but partially dependent of mammalian target of rapamycin (mTOR) signaling...
- Nox4 NAD(P)H oxidase mediates hypertrophy and fibronectin expression in the diabetic kidneyYves Gorin
Department of Medicine, University of Texas Health Science Center, San Antonio, Texas 78229 3900, USA
J Biol Chem 280:39616-26. 2005Renal hypertrophy and extracellular matrix accumulation are early features of diabetic nephropathy...
- Mast cell-derived tumor necrosis factor induces hypertrophy of draining lymph nodes during infectionJames B McLachlan
Department of Pathology, Duke University Medical Center, Durham, North Carolina 27710, USA
Nat Immunol 4:1199-205. 2003..mast cell-derived products in this model indicated that tumor necrosis factor was the main mediator of nodal hypertrophy, whereas tryptase and histamine had no effect...
- Nox1 overexpression potentiates angiotensin II-induced hypertension and vascular smooth muscle hypertrophy in transgenic miceAnna Dikalova
Division of Cardiology, Emory University, Atlanta, GA 30322, USA
Circulation 112:2668-76. 2005..Nox1 upregulation has been implicated in cardiovascular pathologies such as hypertension and restenosis...
- Role of satellite cells versus myofibers in muscle hypertrophy induced by inhibition of the myostatin/activin signaling pathwaySe Jin Lee
Department of Molecular Biology and Genetics, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Proc Natl Acad Sci U S A 109:E2353-60. 2012..The cellular targets for myostatin and activin A in muscle and the role of satellite cells in mediating muscle hypertrophy induced by inhibition of this signaling pathway have not been fully elucidated...
- A-kinase-anchoring protein-Lbc anchors IκB kinase β to support interleukin-6-mediated cardiomyocyte hypertrophyCosmo Damiano Del Vescovo
Département de Pharmacologie et de Toxicologie, University of Lausanne, Lausanne, Switzerland
Mol Cell Biol 33:14-27. 2013In response to stress, the heart undergoes a pathological remodeling process associated with hypertrophy and the reexpression of a fetal gene program that ultimately causes cardiac dysfunction and heart failure...
- Gαi2 signaling promotes skeletal muscle hypertrophy, myoblast differentiation, and muscle regenerationGiulia C Minetti
Novartis Institutes for BioMedical Research, Forum 1, Novartis Campus, 4056 Basel, Switzerland
Sci Signal 4:ra80. 2011..a G protein (heterotrimeric guanine nucleotide-binding protein)-coupled receptor, stimulated skeletal muscle hypertrophy through activation of Gα(i2)...
- Proteome changes in the myocardium of experimental chronic diabetes and hypertension: role of PPARα in the associated hypertrophyS Ares-Carrasco
IIS Fundación Jiménez Díaz, Madrid, Spain
J Proteomics 75:1816-29. 2012..In this regard, PPARα stimulation reduced hypertrophy and pro-hypertrophic factors such as annexin-V in high-glucose and angiotensin-II induced cardiomyocytes...
- Lymph node hypertrophy following Leishmania major infection is dependent on TLR9Lucas P Carvalho
Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
J Immunol 188:1394-401. 2012..An early event in the development of an effective T cell response is the expansion (or hypertrophy) of the lymph node draining the site of infection, although the mechanisms involved in this response are not ..
- Differential effect of saturated and unsaturated free fatty acids on the generation of monocyte adhesion and chemotactic factors by adipocytes: dissociation of adipocyte hypertrophy from inflammationChang Yeop Han
Department of Medicine, University of Washington, Seattle, Washington, USA
Diabetes 59:386-96. 2010..The current objective was to determine how the other major nutrient, free fatty acids (FFAs), affects these molecules and monocyte recruitment by adipocytes...
- Gas6 induces Akt/mTOR-mediated mesangial hypertrophy in diabetic nephropathyKojiro Nagai
Department of Geriatric Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan
Kidney Int 68:552-61. 2005We have already reported Gas6 is involved in glomerular hypertrophy observed in diabetic nephropathy. However, the molecular mechanisms involved in glomerular hypertrophy are still unknown, especially in vivo.
- Ectodermal influx and cell hypertrophy provide early growth for all murine mammary rudiments, and are differentially regulated among them by Gli3May Yin Lee
Institute of Molecular and Cell Biology, Agency for Science, Technology and Research, Singapore, Singapore
PLoS ONE 6:e26242. 2011..During the second day of MR development, peripheral cells within the MRs undergo hypertrophy, which also contributes to MR growth. Limited apoptotic cell death counterbalances MR growth...
- PI3 kinase regulation of skeletal muscle hypertrophy and atrophyDavid J Glass
Novartis Institute for Biomedical Research, Cambridge, MA 02139, USA
Curr Top Microbiol Immunol 346:267-78. 2010Activation of the PI3 kinase pathway can induce skeletal muscle hypertrophy, defined as an increase in skeletal muscle mass...
- TGF-beta/Smad3 signals repress chondrocyte hypertrophic differentiation and are required for maintaining articular cartilageX Yang
Genetics of Development and Disease Branch, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
J Cell Biol 153:35-46. 2001..Without these inhibition signals, chondrocytes break quiescent state and undergo abnormal terminal differentiation, ultimately leading to osteoarthritis...
- High-intensity resistance training amplifies muscle hypertrophy and functional gains in persons with Parkinson's diseaseLeland E Dibble
Division of Physical Therapy, University of Utah, Salt Lake City, Utah, USA
Mov Disord 21:1444-52. 2006..the first clinical trial to investigate and demonstrate the effects of eccentric resistance training on muscle hypertrophy, strength, and mobility in persons with PD...
- Absence of glial fibrillary acidic protein and vimentin prevents hypertrophy of astrocytic processes and improves post-traumatic regenerationUlrika Wilhelmsson
Department of Medical Biochemistry, Sahlgrenska Academy at Goteborg University, SE 405 30 Goteborg, Sweden
J Neurosci 24:5016-21. 2004..Two prominent hallmarks of reactive gliosis are hypertrophy of astrocytic processes and upregulation of intermediate filaments...
- Activation of angiotensin II type 1 receptor-associated protein exerts an inhibitory effect on vascular hypertrophy and oxidative stress in angiotensin II-mediated hypertensionHiromichi Wakui
Department of Medical Science and Cardiorenal Medicine, Yokohama City University Graduate School of Medicine, 3 9 Fukuura, Kanazawa Ku, Yokohama 236 0004, Japan
Cardiovasc Res 100:511-9. 2013..In this study, we investigated the effects of ATRAP on Ang II-induced vascular remodelling...
- A role for AMP-activated protein kinase in diabetes-induced renal hypertrophyMyung Ja Lee
Dept of Nephrology, University of Texas Health Science Center, San Antonio, TX 78229, USA
Am J Physiol Renal Physiol 292:F617-27. 2007..the hypothesis that AMP-activated protein kinase (AMPK), an energy sensor, regulates diabetes-induced renal hypertrophy. In kidney glomerular epithelial cells, high glucose (30 mM), but not equimolar mannitol, stimulated de novo ..
- Habitual loading results in tendon hypertrophy and increased stiffness of the human patellar tendonC Couppe
Institute of Sports Medicine Copenhagen, Bispebjerg Hospital Bispebjerg bakke 23, 2400 Copenhagen NV, Denmark
J Appl Physiol (1985) 105:805-10. 2008..05), whereas the modulus did not differ (lead 2.27 +/- 0.27 GPa vs. nonlead 2.16 +/- 0.28 GPa) at a common force. These data show that a habitual loading is associated with a significant increase in PT size and mechanical properties...
- Lipopolysaccharide induces cellular hypertrophy through calcineurin/NFAT-3 signaling pathway in H9c2 myocardiac cellsChung Jung Liu
Institute of Biochemistry and Biotechnology, Chung Shan Medical University, Taichung, Taiwan
Mol Cell Biochem 313:167-78. 2008..response in the cardiovascular system; however, it is unknown if LPS is sufficient to cause the cardiac hypertrophy. In the present study, we treated H9c2 myocardiac cells with LPS to explore whether LPS causes cardiac ..
- Validation of a new grading system for endoscopic examination of adenoid hypertrophySanjay R Parikh
Department of Otorhinolaryngology Head and Neck Surgery, Albert Einstein College of Medicine, New York, New York, USA
Otolaryngol Head Neck Surg 135:684-7. 2006..To propose and validate a new subjective grading system of adenoid size with flexible fiberoptic evaluation...
- RGS5, RGS4, and RGS2 expression and aortic contractibility are dynamically co-regulated during aortic banding-induced hypertrophyXi Wang
University of Washington, Department of Pathology, Seattle, Washington 98109, USA
J Mol Cell Cardiol 44:539-50. 2008..signaling, we proposed that RGS5 and vascular expressed RGS2 and RGS4 could participate in regulating arterial hypertrophy. We used the suprarenal abdominal aorta banding model to induce hypertension and hypertrophy...
- Activation or inactivation of cardiac Akt/mTOR signaling diverges physiological from pathological hypertrophyOle Johan Kemi
Institute of Biomedical and Life Sciences, University of Glasgow, UK
J Cell Physiol 214:316-21. 2008Cardiomyocyte hypertrophy differs according to the stress exerted on the myocardium...
- Urokinase-type plasminogen activator and macrophages are required for skeletal muscle hypertrophy in miceDana M DiPasquale
Department of Movement Sciences, University of Illinois at Chicago, Chicago, IL 60612, USA
Am J Physiol Cell Physiol 293:C1278-85. 2007..was that the extracellular serine protease, urokinase-type plasminogen activator (uPA), is required for muscle hypertrophy, in part by promoting macrophage accumulation in muscle subjected to increased mechanical loading...
- MEF2C transcription factor controls chondrocyte hypertrophy and bone developmentMichael A Arnold
Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
Dev Cell 12:377-89. 2007Chondrocyte hypertrophy is essential for endochondral bone development...
- Muscle hypertrophy, hormonal adaptations and strength development during strength training in strength-trained and untrained menJuha P Ahtiainen
Neuromuscular Research Center and Department of Biology of Physical Activity, University of Jyvaskyla, P O Box 35, 40014 Jyvaskyla, Finland
Eur J Appl Physiol 89:555-63. 2003..in isometric strength and in muscle CSA suggest that both serum basal testosterone concentrations and training-induced changes in acute testosterone responses may be important factors for strength development and muscle hypertrophy.
- Tsetse salivary gland hypertrophy virus: hope or hindrance for tsetse control?Adly M M Abd-Alla
Insect Pest Control Laboratory, Joint FAO IAEA Division of Nuclear Techniques in Food and Agriculture, Vienna, Austria
PLoS Negl Trop Dis 5:e1220. 2011MANY SPECIES OF TSETSE FLIES (DIPTERA: Glossinidae) are infected with a virus that causes salivary gland hypertrophy (SGH), and flies with SGH symptoms have a reduced fecundity and fertility...
- Cardiac O-GlcNAc signaling is increased in hypertrophy and heart failureIda G Lunde
Institute for Experimental Medical Research, Oslo University Hospital Ullevaal, Oslo, Norway
Physiol Genomics 44:162-72. 2012..We tested the hypothesis that cardiac O-GlcNAc signaling is altered in chronic cardiac hypertrophy and failure of different etiologies...
- Hypoxia increases muscle hypertrophy induced by resistance trainingAkinobu Nishimura
Department of Orthopaedic Surgery, Mie University Graduate School of Medicine, Tsu City, Mie Prefecture, Japan
Int J Sports Physiol Perform 5:497-508. 2010..have shown that low-intensity resistance training with vascular occlusion (kaatsu training) induces muscle hypertrophy. A local hypoxic environment facilitates muscle hypertrophy during kaatsu training...
- Heart angiotensin II-induced cardiomyocyte hypertrophy suppresses coronary angiogenesis and progresses diabetic cardiomyopathyTakahiro Masuda
Divisions of Nephrology, Department of Internal Medicine, Jichi Medical University, Yakushiji, Shimotsuke, Japan
Am J Physiol Heart Circ Physiol 302:H1871-83. 2012To examine whether and how heart ANG II influences the coordination between cardiomyocyte hypertrophy and coronary angiogenesis and contributes to the pathogenesis of diabetic cardiomyopathy, we used Spontaneously Diabetic Torii (SDT) ..
- Activation of Indian hedgehog promotes chondrocyte hypertrophy and upregulation of MMP-13 in human osteoarthritic cartilageF Wei
Department of Orthopedics, Warren Alpert Medical School of Brown University, Providence, RI 02903, USA
Osteoarthritis Cartilage 20:755-63. 2012..the correlation between osteoarthritis (OA) and Indian hedgehog (Ihh) expression, and (2) establish the effects of Ihh on expression of markers of chondrocyte hypertrophy and matrix metalloprotease (MMP)-13 in human OA cartilage.
- Resistance exercise load does not determine training-mediated hypertrophic gains in young menCameron J Mitchell
Exercise Metabolism Research Group, Department of Kinesiology, McMaster Univ, 1280 Main St, West, Hamilton, Ontario, L8S4L8, Canada
J Appl Physiol (1985) 113:71-7. 2012..synthesis rates, with differing nutritional support, are predictive of longer-term training-induced muscle hypertrophy. Here, we aimed to test whether the same was true with acute exercise-mediated changes in muscle protein ..
- The transcriptional co-activators CREB-binding protein (CBP) and p300 play a critical role in cardiac hypertrophy that is dependent on their histone acetyltransferase activityRosalind J Gusterson
Institute of Child Health, University College London, 30 Guilford St, London WC1N 1EH, United Kingdom
J Biol Chem 278:6838-47. 2003..that inhibition of either CBP or p300 with antisense or dominant negative mutant constructs inhibits PE-induced hypertrophy as assayed by atrial naturetic protein production, cardiac cell protein:DNA ratio and cell size...
- Follistatin-mediated skeletal muscle hypertrophy is regulated by Smad3 and mTOR independently of myostatinCatherine E Winbanks
Division of Metabolism and Obesity, Baker IDI Heart and Diabetes Institute, Victoria 3004, Australia
J Cell Biol 197:997-1008. 2012..These findings identify a critical role of Smad3/Akt/mTOR/S6K/S6RP signaling in follistatin-mediated muscle growth that operates independently of myostatin-driven mechanisms...
- Correlation between structure, protein composition, morphogenesis and cytopathology of Glossina pallidipes salivary gland hypertrophy virusHenry M Kariithi
Laboratory of Virology, Wageningen University, Wageningen, The Netherlands
J Gen Virol 94:193-208. 2013The Glossina pallidipes salivary gland hypertrophy virus (GpSGHV) is a dsDNA virus with rod-shaped, enveloped virions. Its 190 kb genome contains 160 putative protein-coding ORFs...
- Type I insulin-like growth factor receptor signaling in skeletal muscle regeneration and hypertrophyA Philippou
Department of Experimental Physiology, Medical School, National and Kapodistrian University of Athens, Goudi Athens, Greece
J Musculoskelet Neuronal Interact 7:208-18. 2007..Both cellular processes, muscle regeneration and hypertrophy, are mediated by the activation, proliferation and differentiation of muscle satellite cells and appear to be ..
- Rapamycin suppresses seizures and neuronal hypertrophy in a mouse model of cortical dysplasiaM Cecilia Ljungberg
The Cain Foundation Laboratories, Texas Children s Hospital, Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA
Dis Model Mech 2:389-98. 2009..These findings support the possibility that this drug may be developed as a novel antiepileptic treatment for patients with cortical dysplasia and similar disorders...
- SIRT1 inhibits angiotensin II-induced vascular smooth muscle cell hypertrophyLi Li
National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
Acta Biochim Biophys Sin (Shanghai) 43:103-9. 2011Angiotensin II (Ang II) stimulates vascular smooth muscle cell (VSMC) hypertrophy as a critical event in the development of vascular diseases such as atherosclerosis...
- Astrocytic hypertrophy in anterior cingulate white matter of depressed suicidesSusana G Torres-Platas
McGill Group for Suicide Studies, Department of Neurology and Neurosurgery, Douglas Mental Health University Institute, McGill University, Verdun, Quebec, Canada
Neuropsychopharmacology 36:2650-8. 2011..The presence of hypertrophic astrocytes in BA24 white matter is consistent with reports suggesting white matter alterations in depression, and provides further support to the neuroinflammatory theory of depression...
- Calcineurin is activated in diabetes and is required for glomerular hypertrophy and ECM accumulationJennifer L Gooch
South Texas Veterans Health Care Administration, Audie Murphy Memorial Hospital, San Antonio 78284 3900, USA
Am J Physiol Renal Physiol 284:F144-54. 2003Diabetic nephropathy is characterized by the rapid onset of hypertrophy and ECM expansion. Previously, we showed that calcineurin phosphatase is required for hypertrophy and ECM synthesis in cultured mesangial cells...
- MMP-2/TIMP-2/TIMP-4 versus MMP-9/TIMP-3 in transition from compensatory hypertrophy and angiogenesis to decompensatory heart failureSrikanth Givvimani
Department of Physiology and Biophysics, University of Louisville School of Medicine, 500 South Preston Street, Louisville, KY 40202, USA
Arch Physiol Biochem 116:63-72. 2010..Interestingly, a disruption of co-ordinated cardiac hypertrophy and angiogenesis contributed to the transition to heart failure, however, the proteolytic and anti-angiogenic ..
- Role of mammalian target of rapamycin signaling in compensatory renal hypertrophyJian Kang Chen
Division of Nephrology, Department of Medicine, Vanderbilt University School of Medicine, S 3223 Medical Center North, Nashville, Tennessee 37232, USA
J Am Soc Nephrol 16:1384-91. 2005..This growth largely occurs by hypertrophy rather than from hyperplasia of the remaining nephrons...
- The insulin-like growth factor (IGF)-I E-peptides are required for isoform-specific gene expression and muscle hypertrophy after local IGF-I productionElisabeth R Barton
Department of Anatomy and Cell Biology, School of Dental Medicine, Pennsylvania Muscle Institute, University of Pennsylvania, 240 S 40th St, 441 Levy Bldg, Philadelphia, PA 19104, USA
J Appl Physiol (1985) 108:1069-76. 2010..At 4 mo after viral delivery, expression of IGF-IA or IGF-IB promoted muscle hypertrophy, but viral delivery of mature IGF-I failed to increase muscle mass...
- Elevated levels of active matrix metalloproteinase-9 cause hypertrophy in skeletal muscle of normal and dystrophin-deficient mdx miceSaurabh Dahiya
Department of Anatomical Sciences and Neurobiology, University of Louisville School of Medicine, Louisville, KY 40202, USA
Hum Mol Genet 20:4345-59. 2011..one-year-old mdx mice (a model for Duchenne muscular dystrophy, DMD), deletion of the Mmp9 gene reduced fiber hypertrophy and phosphorylation of Akt and p38 mitogen-activated protein kinase...
- Protein supplementation before and after exercise does not further augment skeletal muscle hypertrophy after resistance training in elderly menLex B Verdijk
Department of Human Movement Sciences, Nutrition and Toxicology Research Institute Maastricht NUTRIM, Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, Netherlands
Am J Clin Nutr 89:608-16. 2009..Considerable discrepancy exists in the literature on the proposed benefits of protein supplementation on the adaptive response of skeletal muscle to resistance-type exercise training in the elderly...
- Translational signaling responses preceding resistance training-mediated myofiber hypertrophy in young and old humansDavid L Mayhew
UAB Dept of Physiology, 966 McCallum Basic Health Sciences Bldg, 1530 3rd Ave South, Birmingham, AL 35294 0005, USA
J Appl Physiol (1985) 107:1655-62. 2009While skeletal muscle protein accretion during resistance training (RT)-mediated myofiber hypertrophy is thought to result from upregulated translation initiation signaling, this concept is based on responses to a single bout of ..
- Recovery after chronic stress fails to reverse amygdaloid neuronal hypertrophy and enhanced anxiety-like behaviorA Vyas
National Centre for Biological Sciences, Tata Institute of Fundamental Research, GKVK P O, Bangalore 560065, India
Neuroscience 128:667-73. 2004..Moreover, CIS-induced BLA hypertrophy is distinct from hippocampal CA3 atrophy, which is reversible within the same period of stress-free recovery...
- Role of MAPK phosphatase-1 in the induction of monocyte chemoattractant protein-1 during the course of adipocyte hypertrophyAyaka Ito
Department of Molecular Medicine and Metabolism, Medical Research Institute, Tokyo Medical and Dental University, and Department of Medicine, National Cardiovascular Center Hospital, Osaka, Japan
J Biol Chem 282:25445-52. 2007..protein kinase (MAPK) phosphatase-1 (MKP-1) in the induction of MCP-1 during the course of adipocyte hypertrophy. We examined the time course of MKP-1 and MCP-1 mRNA expression and extracellular signal-regulated kinase (ERK) ..
- Acute corticosterone treatment is sufficient to induce anxiety and amygdaloid dendritic hypertrophyRupshi Mitra
Department of Biology, Stanford University, Gilbert Building, Stanford, CA 94305, USA
Proc Natl Acad Sci U S A 105:5573-8. 2008Stress is known to induce dendritic hypertrophy in the basolateral amygdala (BLA) and to enhance anxiety. Stress also leads to secretion of glucocorticoids (GC), and the BLA has a high concentration of glucocorticoid receptors...
- A functional insulin-like growth factor receptor is not necessary for load-induced skeletal muscle hypertrophyEspen E Spangenburg
Department of Kinesiology, University of Maryland, College Park, MD 21045, USA
J Physiol 586:283-91. 2008..of insulin-like growth factor I (IGF-I), which is thought to be a critical step in the induction of muscle hypertrophy. To determine the role of the IGF-I receptor in load-induced skeletal muscle hypertrophy, we utilized a ..
- Foxo3a inhibits cardiomyocyte hypertrophy through transactivating catalaseWei Qi Tan
Division of Cardiovascular Research, National Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China
J Biol Chem 283:29730-9. 2008The forkhead transcription factor Foxo3a is able to inhibit cardiomyocyte hypertrophy. However, its underlying molecular mechanism remains to be fully understood...
- Inhibition of mTOR signaling with rapamycin attenuates renal hypertrophy in the early diabetic miceMasayoshi Sakaguchi
Department of Medicine, Shiga University of Medical Science, Otsu, Shiga, Japan
Biochem Biophys Res Commun 340:296-301. 2006Early diabetic nephropathy is characterized by renal hypertrophy that is mainly due to proximal tubular hypertrophy...
- Gene expression in human chondrocytes in late osteoarthritis is changed in both fibrillated and intact cartilage without evidence of generalised chondrocyte hypertrophyC J Brew
Wellcome Trust Centre for Cell Matrix Research, University of Manchester, Manchester, UK
Ann Rheum Dis 69:234-40. 2010To investigate changes in gene expression in fibrillated and intact human osteoarthritis (OA) cartilage for evidence of an altered chondrocyte phenotype and hypertrophy.
- Myeloid mineralocorticoid receptor controls macrophage polarization and cardiovascular hypertrophy and remodeling in miceMichael G Usher
Department of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, Michigan 48109 5622, USA
J Clin Invest 120:3350-64. 2010..In vivo, MR deficiency in macrophages mimicked the effects of MR antagonists and protected against cardiac hypertrophy, fibrosis, and vascular damage caused by L-NAME/Ang II...
- 1,25-Dihydroxyvitamin D3 decreases podocyte loss and podocyte hypertrophy in the subtotally nephrectomized ratAlexander Kuhlmann
Department of Pathology, Universitiy of Erlangen Nuremberg, Krankenhausstr 8 10, D 91054 Erlangen, Germany
Am J Physiol Renal Physiol 286:F526-33. 2004..This notion is suggested by less evidence of podocyte injury, decreased podocytes loss, and abrogation of podocyte hypertrophy, findings that may also explain less pronounced albuminuria and glomerulosclerosis.
- Mechanical stretch up-regulates microRNA-26a and induces human airway smooth muscle hypertrophy by suppressing glycogen synthase kinase-3βJunaith S Mohamed
Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, Baylor College of Medicine, Houston, Texas 77030, USA
J Biol Chem 285:29336-47. 2010Airway smooth muscle hypertrophy is one of the hallmarks of airway remodeling in severe asthma. Several human diseases have been now associated with dysregulated microRNA (miRNA) expression...
- A phosphatidylinositol 3-kinase/protein kinase B-independent activation of mammalian target of rapamycin signaling is sufficient to induce skeletal muscle hypertrophyCraig A Goodman
Department of Comparative Biosciences, School of Veterinary Medicine, University of Wisconsin, Madison, WI 53706, USA
Mol Biol Cell 21:3258-68. 2010..by mammalian target of rapamycin (mTOR) is both necessary and sufficient for the induction of skeletal muscle hypertrophy. Evidence for this hypothesis is largely based on studies that used stimuli that activate mTOR via a ..
- Myonuclei acquired by overload exercise precede hypertrophy and are not lost on detrainingJ C Bruusgaard
Department of Molecular Biosciences, University of Oslo, 0371 Oslo, Norway
Proc Natl Acad Sci U S A 107:15111-6. 2010..The myonuclei seem to be protected from the high apoptotic activity found in inactive muscle tissue. A hypertrophy episode leading to a lasting elevated number of myonuclei retarded disuse atrophy, and the nuclei could serve ..
- Nox4 NAD(P)H oxidase mediates Src-dependent tyrosine phosphorylation of PDK-1 in response to angiotensin II: role in mesangial cell hypertrophy and fibronectin expressionKaren Block
Department of Medicine, University of Texas Health Science Center, 7723 Floyd Curl Drive, San Antonio, TX 78229, USA
J Biol Chem 283:24061-76. 2008Activation of glomerular mesangial cells (MCs) by angiotensin II (Ang II) leads to hypertrophy and extracellular matrix accumulation...
- Nox4 mediates TGF-beta1-induced retinoblastoma protein phosphorylation, proliferation, and hypertrophy in human airway smooth muscle cellsAnne Sturrock
Division of Respiratory, Critical Care and Occupational Pulmonary Medicine, University of Utah Health Sciences Center and Veterans Administration Medical Center, Salt Lake City, Utah 84132, USA
Am J Physiol Lung Cell Mol Physiol 292:L1543-55. 2007..plays a pivotal role in increasing airway smooth muscle mass in severe asthma by inducing proliferation and hypertrophy of human airway smooth muscle. The mechanism(s) for these effects of TGF-beta1 have not been fully elucidated...
- Skeletal muscle hypertrophy following resistance training is accompanied by a fiber type-specific increase in satellite cell content in elderly menLex B Verdijk
Department of Human Movement Sciences, Faculty of Health, Medicine and Life Sciences, Maastricht University, P O Box 616, 6200 MD Maastricht, The Netherlands
J Gerontol A Biol Sci Med Sci 64:332-9. 2009We determined muscle fiber type-specific hypertrophy and changes in satellite cell (SC) content following a 12-week resistance training program in 13 healthy, elderly men (72 +/- 2 years)...
- The ABCs of IGF-I isoforms: impact on muscle hypertrophy and implications for repairElisabeth R Barton
Department of Anatomy and Cell Biology, School of Dental Medicine, and Pennsylvania Muscle Institute, University of Pennsylvania, Philadelphia, PA 19104, USA
Appl Physiol Nutr Metab 31:791-7. 2006..These possibilities have gained the attention of the skeletal muscle field, where novel actions of IGF-I could have significant impact on muscle mass, strength, and repair...
- Advanced glycation end-products induce basement membrane hypertrophy in endoneurial microvessels and disrupt the blood-nerve barrier by stimulating the release of TGF-β and vascular endothelial growth factor (VEGF) by pericytesF Shimizu
Department of Neurology and Clinical Neuroscience, Yamaguchi University Graduate School of Medicine, 1 1 1 Minami kogushi, Ube, Yamaguchi 7558505, Japan
Diabetologia 54:1517-26. 2011..Although basement membrane hypertrophy and breakdown of the BNB are characteristic features of diabetic neuropathy, the underlying pathogenesis ..
- Chronic treatment with a glucagon receptor antagonist lowers glucose and moderately raises circulating glucagon and glucagon-like peptide 1 without severe alpha cell hypertrophy in diet-induced obese miceJ Mu
Merck, RY80N A58, 126 East Lincoln Avenue, Rahway, NJ, USA
Diabetologia 54:2381-91. 2011..Antagonism of the glucagon receptor (GCGR) represents a potential approach for treating diabetes. Cpd-A, a potent and selective GCGR antagonist (GRA) was studied in preclinical models to assess its effects on alpha cells...
- Antisense-induced myostatin exon skipping leads to muscle hypertrophy in mice following octa-guanidine morpholino oligomer treatmentJagjeet K Kang
School of Biological Sciences, Royal Holloway University of London, Egham, Surrey, UK
Mol Ther 19:159-64. 2011....
- The emerging role of NO and IGF-1 in early renal hypertrophy in STZ-induced diabetic ratsNomy Levin-Iaina
Department of Nephrology and Hypertension, Sheba Medical Center, Sackler School of Medicine, Tel Aviv University, Tel Hashomer, Israel
Diabetes Metab Res Rev 27:235-43. 2011..DN is characterized by early hyperfiltration and renal hypertrophy, which are associated with increased renal insulin-like growth factor-1 (IGF-1) levels...
- Efficacy of 3 days/wk resistance training on myofiber hypertrophy and myogenic mechanisms in young vs. older adultsDavid J Kosek
UAB Dept of Physiology and Biophysics, Muscle Research Laboratory, GRECC 11G VA Medical Center, 1530 3rd Ave, South Birmingham, AL 35294 0001, USA
J Appl Physiol (1985) 101:531-44. 2006..We hypothesized myofiber hypertrophy resulting from frequent (3 days/wk, 16 wk) RT would be impaired in older (O; 60-75 yr; 12 women, 13 men), ..
- Calcification of articular cartilage in human osteoarthritisM Fuerst
Department of Orthopaedic Surgery, University Medical Center Hamburg Eppendorf, Clinic Bad Bramstedt, Martinistrasse 52, Hamburg, Germany
Arthritis Rheum 60:2694-703. 2009..Although chondrocyte hypertrophy has been associated with osteoarthritis (OA), chondrocalcinosis has been considered an irregular event and ..
- Regulation of chondrocyte differentiation by Cbfa1I S Kim
Universitäts Kinderklinik Mainz, Langenbeckstrasse 1, 55101, Mainz, Germany
Mech Dev 80:159-70. 1999..a lack of hypertrophic chondrocytes in the anlagen of the humerus and the phalanges and a delayed onset of hypertrophy in radius/ulna in Cbfa1-/- mice...
- Obstructive sleep apnea in children: relative contributions of body mass index and adenotonsillar hypertrophyEhab Dayyat
Department of Pediatrics, Division of Pediatric Sleep Medicine, The University of Chicago, Chicago, IL 60637, USA
Chest 136:137-44. 2009The obesity epidemic has prompted remarkable changes in the proportion of obese children who are referred for habitual snoring. However, the contribution of obesity to adenotonsillar hypertrophy remains undefined.
- Role of EGF receptor activation in angiotensin II-induced renal epithelial cell hypertrophyJianchun Chen
Department of Medicine, Vanderbilt University School of Medicine, and Department of Veterans Affairs, Nashville, TN 37232, USA
J Am Soc Nephrol 17:1615-23. 2006For determination of the molecular mechanisms underlying the induction of epithelial cell hypertrophy by angiotensin II (Ang II), a well-characterized porcine renal proximal tubular cell line LLCPKcl4, which does not express endogenous ..
- Parathyroid hormone-related peptide represses chondrocyte hypertrophy through a protein phosphatase 2A/histone deacetylase 4/MEF2 pathwayElena Kozhemyakina
Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, 240 Longwood Ave, Boston, MA 02115, USA
Mol Cell Biol 29:5751-62. 2009..nuclear translocation of HDAC4 and attenuates the ability of this signaling molecule to repress collagen X expression in chondrocytes, indicating that PP2A is critical for PTHrP-mediated regulation of chondrocyte hypertrophy.
- A reaction-diffusion model for long bones growthD A Garzón-Alvarado
Aragon Institute of Engineering Research, University of Zaragoza, Spain
Biomech Model Mechanobiol 8:381-95. 2009..Chondrocytes proliferation and hypertrophy are described by means of population equations being both regulated by the PTHrP and Ihh concentrations...
- Ubiquitous overexpression of Hey1 transcription factor leads to osteopenia and chondrocyte hypertrophy in boneRishard Salie
Musculoskeletal Disease Area, Novartis Institutes for BioMedical Research, Basel, Switzerland
Bone 46:680-94. 2010..Due to the complex role of Hey1 in bone, inhibition of Hey1 does not appear to be a straightforward therapeutic strategy to increase the bone mass...
- Effects of testosterone supplementation on skeletal muscle fiber hypertrophy and satellite cells in community-dwelling older menIndrani Sinha-Hikim
Division of Endocrinology, Metabolism, and Molecular Medicine, Charles R Drew University, Los Angeles, CA 90059, USA
J Clin Endocrinol Metab 91:3024-33. 2006..In this study, we determined the effects of graded doses of testosterone on muscle fiber cross-sectional area (CSA) and satellite cell number and replication in older men...
- Vascular hypertrophy in angiotensin II-induced hypertension is mediated by vascular smooth muscle cell-derived H2O2Yong Zhang
Division of Cardiology, Department of Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
Hypertension 46:732-7. 2005Angiotensin II induces the development of vascular hypertrophy and hypertension. An increasing number of studies have demonstrated that reactive oxygen species are involved in many of the vascular responses to angiotensin II...
- IL-13 mediates the recruitment of reserve cells for fusion during IGF-1-induced hypertrophy of human myotubesVirginie Jacquemin
UMR S 787, Inserm UPMC Paris 6, Institut de Myologie, Paris, France
J Cell Sci 120:670-81. 2007Insulin-like growth factor-1 (IGF-1) has been shown to induce skeletal muscle hypertrophy, to prevent the loss of muscle mass with ageing and to improve the muscle phenotype of dystrophic mice...
- Reactive oxygen species induce chondrocyte hypertrophy in endochondral ossificationKozo Morita
Department of Cell Differentiation, The Sakaguchi Laboratory of Developmental Biology, Keio University School of Medicine, Shinjuku ku, Tokyo 160 8582, Japan
J Exp Med 204:1613-23. 2007Chondrocyte hypertrophy during endochondral ossification is a well-controlled process in which proliferating chondrocytes stop proliferating and differentiate into hypertrophic chondrocytes, which then undergo apoptosis...
- Oculopalatal tremor explained by a model of inferior olivary hypertrophy and cerebellar plasticityAasef G Shaikh
Department of Neurology, The Johns Hopkins University, Baltimore, MD 21287, USA
Brain 133:923-40. 2010..We conclude that oculopalatal tremor oscillations originate in the hypertrophic inferior olive and are amplified by learning in the cerebellum...
- Involvement of transient receptor potential canonical 1 (TRPC1) in angiotensin II-induced vascular smooth muscle cell hypertrophyYoichiro Takahashi
Second Department of Internal Medicine, Akita University School of Medicine, 1 1 1 Hondoh, Akita 010 8543, Japan
Atherosclerosis 195:287-96. 2007Angiotensin II (Ang II) induces vascular smooth muscle cell (VSMC) hypertrophy as one of the major events leading to atherosclerosis...
- Characterization and Development of a New Animal Model of Pulmonary HypertensionSylvia McCune; Fiscal Year: 2007..Spontaneously Hypertensive Heart Failure (SHHF) rats that present with PH and massive, early (~ 2 months), RV hypertrophy - RV hypertrophy that appears to precede and vastly exceed that observed in the left ventricle...
- Cardiac Angiotensin: Hypertrophy and FailureJames Morgan; Fiscal Year: 2004..description verbatim): The angiotensin II type 2 (AT2) receptor predominates in the left ventricle (LV) in hypertrophy and heart failure, and AT2 receptor activation suppresses growth and promotes apoptosis in vitro...
- EXPRESSION AND REGULATION OF ATRIAL NATRIURETIC FACTORDavid Gardner; Fiscal Year: 2002..in the adult ventricular myocyte but can be reactivated under pathological conditions associated with hypertrophy. In fact, expression of these genes has come to represent one of the earliest and most reliable genetic markers ..
- REVERSAL OF MYOCARDIAL HYPERTROPHY IN HYPERTENSIONSubha Sen; Fiscal Year: 2002..objective of this project is to study the underlying mechanisms in the development and regression of myocardial hypertrophy in hypertension...
- Air Pollution on Adiposity and Vascular Dysfunction: White or Brown Matters?Qinghua Sun; Fiscal Year: 2013..brown adipose tissue, tissue histological examination to assess mitochondria content, adipocyte hyperplasia and hypertrophy, and vascular growth in the fat tissues, myograph to investigate macrovascular function will be performed...
- Effects of Evoked Resistance Training and Testosterone after Spinal Cord InjuryAshraf Gorgey; Fiscal Year: 2012..We concluded that twelve weeks of evoked RT targeted towards evoking skeletal muscle hypertrophy could result in significant body composition and metabolic adaptations in individuals with SCI...
- Insulin Signaling and the Heart in DiabetesEVAN DALE ABEL; Fiscal Year: 2011..maintaining myocardial viability in the face of hemodynamic stressors such as ischemia and pathological cardiac hypertrophy. Moreover, we identified a central role for PI3K signaling in coordinating the mitochondrial adaptation to ..
- BIOSYNTHESIS OF TRACHEAL MUCOUS GLYCOPROTEINSPi Wan Cheng; Fiscal Year: 2010..This condition is the result of hypertrophy and hyperplasia of mucus cells...
- The role of IKK beta in cardiomyocytes at baseline and following stressMATTHEW PETER COGGINS; Fiscal Year: 2013..of Cardiovascular Research at Beth Israel Deaconess Medical Center, who has expertise in the field of cardiac hypertrophy, heart failure and remodeling, and kinase signaling pathways...
- Regulation of myocardial growth and death by GSK-3Junichi Sadoshima; Fiscal Year: 2013..During the current funding cycle, we established that GSK-3 is a negative regulator of cardiac hypertrophy and has substantial influence on cardiac function when its activity is modulated by phosphorylation during ..
- New insights in mechanisms of renal injuryBalakuntalam S Kasinath; Fiscal Year: 2013..This occurs in association with renal hypertrophy, increase in renal matrix laminin beta1 and fibronectin expression, and albuminuria. 2...
- Bisphosphonates in the treatment of chronic kidney disease-mineral bone diseaseSharon M Moe; Fiscal Year: 2013..hyperparathyroidism, increased bone remodeling and bone loss, arterial calcification, and left ventricular hypertrophy, accurately reflecting the clinical disease progression observed in humans with CKD...
- ALTERED CARDIAC MYOCYTE SIGNALING IN DIABETIC MYOCARDIUM AND FUNCTIONAL SEQUELAEANTHONY JUSTIN MUSLIN; Fiscal Year: 2010..that occurs in the absence of hypertension or coronary artery disease and that is characterized by ventricular hypertrophy, decreased ventricular diastolic relaxation, and a reduced peak filling rate...
- Gene Therapy with Cardiotropic Vectors for the Treatment of Heart FailureRoger J Hajjar; Fiscal Year: 2013..contractility and, most importantly, reversal of adverse remodeling by directly decreasing fibrosis and cardiac hypertrophy. We therefore propose to take advantage of novel vectors, which we have developed for cardiac specific gene ..
- Targeting Cell Death to Prevent Ventricular Remodeling and Heart FailureAbhinav Diwan; Fiscal Year: 2011..The common cellular event that defines both myocardial infarction and the progression from compensated cardiac hypertrophy to decompensated heart failure is death of cardiomyocytes...
- A Bifunctional Katp Channel Activator and Redox Mimetic for BPDKanneganti Murthy; Fiscal Year: 2013..The heart will also be analyzed for evidence of PAH (as evidenced by right ventricular hypertrophy)...
- Air Pollution on Adiposity and Vascular Dysfunction: White or Brown Matters?Qinghua Sun; Fiscal Year: 2010..brown adipose tissue, tissue histological examination to assess mitochondria content, adipocyte hyperplasia and hypertrophy, and vascular growth in the fat tissues, intravital microscopy to illustrate microvascular function and ..
- Modifiers of Cyst Progression in Polycystic Kidney DiseasePhillip Darwin Bell; Fiscal Year: 2013..In addition, lack of cilia or mutations in cystoproteins may affect the renal adaptive response to hypertrophy and hyperglycemia Specific objectives: (1) investigate reduced renal mass (nephrectomy), hyperglycemia (..
- Lipid Binding Proteins in Obesity and Diabetes SyndromesDavid A Bernlohr; Fiscal Year: 2013..included increased lipolysis, exacerbated insulin resistance, decreased adiponectin secretion, and mild cardiac hypertrophy. Humans with decreased adipocyte FABP (arising via a polymorphism in the AFABP/aP2 promoter) exhibit reduced ..
- Novel Means to Establish Free Radical Balance in the Neonatal Premature LungPrakash Jagtap; Fiscal Year: 2011..arrest and reversal of the progression in pulmonary fibrosis and alveolar inflammation, and blocked vascular hypertrophy and attenuated PAH...
- A Novel Thioredoxin Mimetic Prodrug for Prevention of Bronchopulmonary DysplasiaPrakash Jagtap; Fiscal Year: 2013..The heart will undergo morphometric analysis for evidence of PAH (as shown by right ventricular (RV) hypertrophy).
- Cholesterol and Lymphatic Transport of Molecules and CellsMelody A Swartz; Fiscal Year: 2012..in mouse models of lymphedema and promotes swelling, elevated plasma cholesterol levels, and adipocyte hypertrophy (aim 3)...
- Novel Regenerative Therapy for Myocardial InfarctionAndrew R Mendelsohn; Fiscal Year: 2011..with NRG1b1 had permanently improved myocardial function, smaller infarct scar size, and attenuated myocardial hypertrophy. Prior work has shown that NRG1b1 effectively treated ischemic, dilated, and viral cardiomyopathies in mouse, ..
- Innate Immunity and Cardiovascular FunctionGregory L Stahl; Fiscal Year: 2013..e., loss of endothelium-dependent relaxation) and cardiomyopathy (i.e., left ventricular dysfunction, hypertrophy and cardiac fibrosis)...
- Mechanisms of Obesity in Mice with Neuron-Specific Lipoprotein Lipase DeficiencyRobert H Eckel; Fiscal Year: 2013..increases in Mc3r gene expression in the hypothalamus, marked brown adipose tissue (BAT) hyperplasia/hypertrophy and increased BAT UCP-1 gene expression...
- Lipid Binding Proteins in Obesity and Diabetes SyndromesDavid A Bernlohr; Fiscal Year: 2011..included increased lipolysis, exacerbated insulin resistance, decreased adiponectin secretion, and mild cardiac hypertrophy. Humans with decreased adipocyte FABP (arising via a polymorphism in the AFABP/aP2 promoter) exhibit reduced ..
- Targeting GRK2 (BARK1) in Heart FailureWalter J Koch; Fiscal Year: 2013..HF often occurs after myocardial injury or stress such as ischemia or pressure-overload with cardiac hypertrophy occurring first, followed by ventricular remodeling and a loss of contractile function and [unreadable]-..
- Modulation of Natriuretic Peptides via Caveolin in Hypertrophy and Heart Failure.David M Roth; Fiscal Year: 2013DESCRIPTION (provided by applicant): Project Summary/Abstract Cardiac hypertrophy is a critical determinant of cardiac remodeling and the progression of heart failure...
- Mechanisms of Airway Smooth Muscle HypertrophyMarc B Hershenson; Fiscal Year: 2013..Completion of this work will provide insight into the pathogenesis of BPD, lead to the development of more accurate biomarkers, and provide new information on the role of matricellular proteins in lung fibrosis. ..
- Markers of Renal Damage in Renovascular HypertensionJuan C Romero; Fiscal Year: 2011..deficit in the ST-KD;b) the degree of increase in blood pressure;and c) the functional compensation reaction (hypertrophy) of the CONT-KD...
- Genetic and Pharmacologic Evaluation of the Role of HIF-1a in asthmaLAURA ELISE CROTTY ALEXANDER; Fiscal Year: 2013..Asthma is an inflammatory disease characterized by hypertrophy of smooth muscle, airway obstruction, and increased mucous production3...
- Mechanism of eNOS Uncoupling in the Renal MicrovasculatureYVES CLAUDE GORIN; Fiscal Year: 2013..Ang II and HG result in cell hypertrophy and fibronectin expression in cultured renal cells through generation of ROS via the NAD(P)H oxidase isoenzyme ..
- Innate Immunity and Cardiovascular FunctionGregory L Stahl; Fiscal Year: 2010..e., loss of endothelium-dependent relaxation) and cardiomyopathy (i.e., left ventricular dysfunction, hypertrophy and cardiac fibrosis)...
- Mechanisms in transcriptional regulation during cardiac hypertrophyMaha Abdellatif; Fiscal Year: 2013DESCRIPTION (provided by applicant): Cardiac hypertrophy is characterized by a generalized increase in gene expression that is commensurate with the increase in myocyte size and mass, on which is superimposed more robust changes in the ..
- ETS-1 and Vascular and Renal Injury in Salt Sensitive HypertensionEdgar A Jaimes; Fiscal Year: 2013..with an increased risk for the development of end-organ injury including atherosclerosis, left ventricular hypertrophy and renal disease...
- Impact of AMP-activated kinase on sex differences in hypertrophic cardiomyopathyJohn P Konhilas; Fiscal Year: 2013..develop HCM characterized by progressive left-ventricular dilation and cardiac dysfunction whereas females show hypertrophy without dilation or dysfunction. However, the mechanisms that underlie these differences remain unknown...
- VASODEPRESSOR MECHANISMS IN HYPERTENSIONCarlos M Ferrario; Fiscal Year: 2013..the effects of Ang II by up-regulating mitogen-activated protein kinase phosphatases to prevent cardiac hypertrophy and reduce fibrosis;Project 3 evaluates the role of nuclear receptors for Ang II and Ang-(1-7) within the ..
- Arrhythmia Mechanisms in Sarcomeric CardiomyopathiesBjorn C Knollmann; Fiscal Year: 2012..While there is a rough relationship between prognosis and the degree of cardiac hypertrophy and fibrosis, this genotype/phenotype correlation is weak...
- Group X sPLA2: Regulator of lipolysis and glucose homeostasisNancy R Webb; Fiscal Year: 2013..The increase in adiposity is associated with adipocyte hypertrophy, which appears to be due at least in part to a defect in 2-adrenergic stimulated lipolysis...
- Pathogenesis of Oxidative Stress in Chagas DiseaseNisha Jain Garg; Fiscal Year: 2013..These pathways converge, resulting in pathological hypertrophy leading to heart failure...
- Interaction of fetal growth and bisphenol A in obesityFrederick S vom Saal; Fiscal Year: 2013..and that BPA will lead to a decrease in the number of adipocytes that are functionally altered and prone to hypertrophy. Perinatal exposure to BPA is predicted to interact synergistically with IUGR via additional epigenetic changes ..
- Endogenous Cardiac Glycosides in AASKBrad C Astor; Fiscal Year: 2010..explained by an elevated prevalence of several CVD risk factors, including hypertension, left ventricular hypertrophy (LVH) and heart failure, which increase in prevalence and severity as kidney function declines...
- Control of Cardiogenesis by microRNA EditingKazuko Nishikura; Fiscal Year: 2010..with congenital ventricular septal defects or pathological conditions of adult heart such as ventricular hypertrophy, hyperplasia and arrhythmias...
- Role of Lipoproteins in Chagasic heart diseaseJYOTHI FALGUNI NAGAJYOTHI; Fiscal Year: 2013..Chagasic heart disease is characterized by myocarditis associated with prominent fibrotic scarring, cardiac hypertrophy, arrhythmia, cardiomyopathy, heart failure and secondary thromboembolism...
- NFATc3 in chronic hypoxic pulmonary hypertensionLaura V Gonzalez Bosc; Fiscal Year: 2012..The hypothesis is that CH activates NFATc3 in PASMC to mediate hypertrophy and enhance contractility of pulmonary arteries (PA) contributing to PAH...
- Peptide Therapy for Pulmonary Arterial HypertensionJawaharlal M Patel; Fiscal Year: 2013..pulmonary hemodynamic modulations (increased PAP, SAP, cardiac output/cardiac index, hematocrit, and RV hypertrophy) and vascular remodeling associated with PH as well as toxicity...
- Functions of the Human OST-alpha and OST-beta ProteinsPatricia M Hinkle; Fiscal Year: 2013..animals have a markedly diminished bile acid pool size, a defect in intestinal bile acid absorption, intestinal hypertrophy, growth retardation, and a decrease in serum cholesterol and triglyceride levels...
- Sleep Disordered Breathing and Growth in Children: A Longitudinal Cohort StudyKaren Bonuck; Fiscal Year: 2009..Adenotonsillar hypertrophy is the primary factor leading to SDB in children...
- Silencing cardiac-specific microRNAs to prevent pathological remodeling in congesMATTHEW SWAN LAWRENCE; Fiscal Year: 2011..shape, or structure of the heart but, significantly, appear resistant to cardiac stress, as shown by a lack of hypertrophy and fibrosis following thoracic aortic banding (TAB)...
- Gq-coupled Receptors Inhibit PI 3-kinase/Akt Signaling PathwayRichard Z Lin; Fiscal Year: 2012..adrenergic receptor agonist known to promote muscle growth in humans and rodents, can still stimulate muscle hypertrophy in muscle‐specific p110alpha or p110beta knockout mice...
- Cell Specific Expression in the Pituitary GlandSally A Camper; Fiscal Year: 2013..Little is known about the mechanism of basic thyrotrope specification or the hypertrophy and hyperplasia...
- Using a MALDI-TOF System for SNP AnalysisNadereh Jafari; Fiscal Year: 2010..Sclerosis, e) investigate the genetic and structural determinants of heart failure and left ventricular hypertrophy, f)rapidly genotype the Y-chromosome and autosomal SNPs to assess the nature of the evolutionary relationships ..
- Angiotensin-induced Oxidants and Vascular Cell PhenotypeRichard Cohen; Fiscal Year: 2009As the blood vessel ages, its cells are subject to pathological changes including hypertrophy, polyploidy, proliferation, apoptosis, and remodeling, and these processes are thought to be a result of complex interactions between ..
- Identification of the transcriptional regulators of chondrocyte hypertrophyANDREW BRUCE LASSAR; Fiscal Year: 2013..Lassar lab has established that forced expression of Runx2 in somites can activate expression of chondrocyte hypertrophy markers (i.e...
- Histone Deacetylation Regulates Growth Plate DevelopmentLei Wei; Fiscal Year: 2013..Specifically, we suspect that HDAC4 functions as a negative regulator of chondrocyte hypertrophy by binding and inhibiting Runx 2/Cbfa1 expression in the nucleus...
- Prostacyclin Synthase and Receptors in Pulmonary Arterial HypertensionMark W Geraci; Fiscal Year: 2011..We hypothesize that signaling through PGIR results in more prominent effects on vascular tone (RV pressures, RV hypertrophy) while PPAR? stimulation results in more effects on vascular remodeling...
- A New Pathway for Neutrophil-induced Airway InflammationJ Edwin Blalock; Fiscal Year: 2013..Prolonged airway exposure to this peptide causes alveolar enlargement and right ventricular hypertrophy and thus recapitulates aspects of COPD...
- Role of Protein Acetylation in Ncx1 ExpressionDonald R Menick; Fiscal Year: 2012..of demonstrating the therapeutic potential of HDAC inhibitors in preserving systolic function in cardiac hypertrophy. PUBLIC HEALTH RELEVANCE: Congestive heart failure is the leading cause of death in the United States...
- Histone Deacetylase Inhibition: A Novel Approach to CardioprotectionTing C Zhao; Fiscal Year: 2012..HDAC inhibition blunts cardiac hypertrophy. Our studies have shown that HDAC inhibition is associated with cardioprotection in acute myocardial ischemia ..
- MECHANISMS OF MALADAPTATION IN HEART FAILUREHoward A Rockman; Fiscal Year: 2013..Furthermore, the proposed studies will lead to new targets to treat cardiac hypertrophy and heart failure in humans.
- Mechanism of Renal Cell Injury in DiabetesGoutam Ghosh Choudhury; Fiscal Year: 2013DESCRIPTION (provided by applicant): Major manifestations of diabetic nephropathy are increased enal hypertrophy involving glomeruli and tubules with expansion of matrix proteins, including fibronectin...
- BIOLOGY OF SUBMUCOSAL GLAND STEM CELLS IN THE AIRWAYJohn F Engelhardt; Fiscal Year: 2013..In diseases such as cystic fibrosis (CF), asthma, and chronic bronchitis, Submucosal glands expand in mass (hypertrophy) and/or abundance (hyperplasia), leading to excessive and abnormal mucus production...
- Mechanisms Involved in Age-Related Loss of Muscle Mass and Growth ResponseSUE CAROL BODINE; Fiscal Year: 2012..During the aging process, skeletal muscle also develops a resistance to grow (or hypertrophy) in response to growth stimuli such as increased loading and nutrition...
- Testosterone Replacement Therapy in Advanced Chronic Kidney DiseaseRalph Rabkin; Fiscal Year: 2009..2. To elucidate the mechanisms whereby TT stimulates muscle hypertrophy in CKD. 3. To determine whether TT can improve some CVD risk factors in CKD...
- A Novel Approach to Phosphorus Lowering in Patients with Chronic Kidney DiseaseJoachim H Ix; Fiscal Year: 2013..Higher serum Pi induces arterial calcification, arterial stiffness, and left ventricular hypertrophy in animals...
- Stem Cells For Myocardial Repair: A Large Bore Magnet StudyJianyi Zhang; Fiscal Year: 2012..PUBLIC HEALTH RELEVANCE: Post-infarction left ventricular remodeling including hypertrophy and chamber dilation occurs to compensate for loss of contractile myocardium...
- AUTONOMIC RECEPTOR FUNCTION IN LV HYPERTROPHY & FAILUREDorothy Vatner; Fiscal Year: 1991..in beta-adrenergic and muscarinic receptor function and adenylate cyclase activity in left ventricular hypertrophy and failure...
- Trypanosoma cruzi-elicited cardiac hypertrophyChristine Petersen; Fiscal Year: 2004Cardiac hypertrophy is a critical step in the progression towards heart failure and a frequent consequence of chronic infections with the intracellular pathogen Trypanosoma cruzi, the causative agent of Chagas' disease in humans...
- Modifier Genes of Familial Hypertrophic CardiomyopathyALI MARIAN; Fiscal Year: 2005The objective is to identify modifier genes that affect hypertrophy in human familial hypertrophic cardiomyopathy (FHCM) and determine whether pharmacological inhibition of their effects can induce regression of established hypertrophy ..
- Effect of Cholesterol Anabolism on Network Signaling in Cardiac HypertrophyMatthew Wheeler; Fiscal Year: 2009Signaling in cardiac hypertrophy has been linked to cholesterol metabolism both through cholesterol precursor mediated post-translational protein modification and cell surface micro-domain mediated signaling complexes...
- The Polycomb/Trithorax system in the regulation of cardiac hypertrophyQUNTIAN WANG; Fiscal Year: 2010..Cardiac hypertrophy is associated with a return to a fetal gene expression program, which weakens cardiac function and promotes ..
- Roles of FGF2 and TGFbeta in cardiac hypertrophyThomas Doetschman; Fiscal Year: 2005Roles of FGF2 and TGFbeta1 in cardiac hypertrophy. Cardiac hypertrophy is thought to be an adaptive response to multiple stresses on the heart, such as mechanical load, hypertension, endocrine imbalance and mutations in sarcomeric ..