Genomes and Genes
Summary: Solid crystalline precipitates in the BILIARY TRACT, usually formed in the GALLBLADDER. Gallstones, derived from the BILE, consist mainly of calcium, cholesterol, or bilirubin.
Publications317 found, 100 shown here
- Genetic and environmental influences on symptomatic gallstone disease: a Swedish study of 43,141 twin pairsDespina Katsika
Department of Medicine at Karolinska University Hospital Huddinge, Karolinska Institutet, Stockholm, Sweden
Hepatology 41:1138-43. 2005..In conclusion, our results show heritability to be a major susceptibility factor for symptomatic gallstone disease, consistent with results from previous, much smaller studies...
- Gallstone diseaseH U Marschall
Department of Medicine, Karolinska Institutet, Karolinska University Hospital, Huddinge, Stockholm, Sweden
J Intern Med 261:529-42. 2007..Aetiology and pathogenesis of cholesterol gallstones still are not well defined, and strategies for prevention and efficient nonsurgical therapies are missing...
- Cholesterol gallstone diseasePiero Portincasa
Department of Internal and Public Medicine, University Medical School, Bari, Italy
Lancet 368:230-9. 2006With a prevalence of 10-15% in adults in Europe and the USA, gallstones are the most common digestive disease needing admission to hospital in the West...
- Cholesterol metabolism gene polymorphisms and the risk of biliary tract cancers and stones: a population-based case-control study in Shanghai, ChinaHong Li Xu
Department of Epidemiology, Cancer Institute of Shanghai Jiao Tong University, China
Carcinogenesis 32:58-62. 2011Biliary tract cancers are rare but fatal malignancies, with increasing incidence in Shanghai, China. Gallstones, the primary risk factor for biliary tract cancer, typically result from oversaturation of cholesterol in bile...
- Predictors of gallstone composition in 1025 symptomatic gallstones from Northern GermanyClemens Schafmayer
Department of General and Thoracic Surgery, University Hospital Schleswig Holstein, Campus Kiel, Arnold Heller Str 7, D 24105 Kiel, Germany
BMC Gastroenterol 6:36. 2006b>Gallstones represent a prevalent and costly health problem. The changing epidemiology and the emerging non-surgical interventions for gallstone disease necessitate the definition of target populations for future therapies...
- Gallstones play a significant role in Salmonella spp. gallbladder colonization and carriageRobert W Crawford
Department of Molecular Virology, Center for Microbial Interface Biology, The Ohio State University, Columbus, OH 43210, USA
Proc Natl Acad Sci U S A 107:4353-8. 2010..the gallbladder and persist in an asymptomatic carrier state that is frequently associated with the presence of gallstones. We have shown that salmonellae form bile-mediated biofilms on human gallstones and cholesterol-coated surfaces ..
- Prevention of cholesterol gallstone disease by FXR agonists in a mouse modelAntonio Moschetta
Howard Hughes Medical Institute and Department of Pharmacology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390 9050, USA
Nat Med 10:1352-8. 2004..Taken together, these results indicate that FXR is a promising therapeutic target for treating or preventing cholesterol gallstone disease...
- Gallstone disease in Swedish twins: risk is associated with ABCG8 D19H genotypeD Katsika
Karolinska Institutet, Department of Medicine, Division of Gastroenterology and Hepatology, Karolinska University Hospital Huddinge, Stockholm, Sweden
J Intern Med 268:279-85. 2010..We investigated these polymorphisms in Swedish twins by merging the Swedish Twin Registry with the Hospital Discharge and Causes of Death Registries for gallstone disease-related diagnoses...
- Role of ABCG8 D19H (rs11887534) variant in gallstone susceptibility in northern IndiaAnshika Srivastava
Departments of Genetics, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India
J Gastroenterol Hepatol 25:1758-62. 2010..We aimed to examine the role of the ABCG8 D19H (rs11887534) polymorphism in susceptibility to gallstone disease in the northern Indian population...
- Dissecting the genetic heterogeneity of gallbladder stone formationMarcin Krawczyk
Department of Medicine II, Saarland University Hospital, Homburg, Germany
Semin Liver Dis 31:157-72. 2011..cholesterol transporter ABCG5/G8 and the bilirubin conjugating enzyme UGT1A1, as major genetic determinants of gallstones in humans...
- Gallstone disease: Epidemiology of gallbladder stone diseaseEldon A Shaffer
Division of Gastroenterology, Health Science Centre, University of Calgary, 3330 Hospital Dr SW, Calgary, Alberta T2N4N1, Canada
Best Pract Res Clin Gastroenterol 20:981-96. 2006..Ten to fifteen per cent of white adults in developed countries harbour gallstones. Frequency is further reduced in Black Americans, East Asia and sub-Saharan Africa...
- Endoscopic balloon dilation compared with sphincterotomy for extraction of bile duct stonesJames A Disario
Division of Gastroenterology, Hepatology and Nutrition, University of Utah Health Science Center, Salt Lake City, UT 84132, USA
Gastroenterology 127:1291-9. 2004..The aim of this study was to determine short-term outcomes of endoscopic balloon dilation of the sphincter of Oddi compared with sphincterotomy for stone extraction...
- Development of symptoms and complications in individuals with asymptomatic gallstonesI Halldestam
Department of Surgery, University Hospital of Linkoping, SE 58185 Linkoping, Sweden
Br J Surg 91:734-8. 2004Gallbladder stones are common in the developed world. Complications of gallstones contribute substantially to healthcare costs and may be life threatening...
- Decreased NPC1L1 expression in the liver from Chinese female gallstone patientsWei Cui
Department of Surgery, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai Institute of Digestive Surgery, 200025, Shanghai, PR China
Lipids Health Dis 9:17. 2010..Many studies have found that cholesterol gallstones are more common in women than men...
- Common variants of ABCB4 and ABCB11 and plasma lipid levels: a study in sib pairs with gallstones, and controlsMonica Acalovschi
3rd Medical Clinic, University Iuliu Hatieganu, Cluj Napoca, Romania
Lipids 44:521-6. 2009..surveys have confirmed the association of low HDL-cholesterol and high triglyceride levels with cholesterol gallstones. Our objective was to analyze the relationship between plasma lipid levels and common polymorphisms of ABCB11 (..
- Hepatic cholesterol transporter ABCG8 polymorphisms in gallstone disease in an Indian populationSiva Prasad Siddapuram
Department of Basic Sciences, Asian Healthcare Foundation, Institute of Basic Sciences, Asian Institute of Gastroenterology, Hyderabad, Andhra Pradesh, India
J Gastroenterol Hepatol 25:1093-8. 2010..cholesterol transporter gene ATP-binding cassette, subfamily G, member 8 (ABCG8) in patients with cholesterol gallstones. The aim of this study was to analyze the relationship between D19H and T400K polymorphisms in the ABCG8 gene ..
- ApoB-100, ApoE and CYP7A1 gene polymorphisms in Mexican patients with cholesterol gallstone diseaseJaime Sánchez-Cuén
División de Gastroenterología, Hospital Regional ISSSTE, Culiacan, Sinaloa 80230, Mexico
World J Gastroenterol 16:4685-90. 2010..To determine the possible association of the ApoB-100 (XbaI), ApoE (HhaI) and CYP7A1 (BsaI) gene polymorphisms, with the development of cholesterol gallstone disease (GD) in a Mexican population...
- Increased NPC1L1 and ACAT2 expression in the jejunal mucosa from Chinese gallstone patientsZhao Yan Jiang
Department of Surgery, Shanghai Institute of Digestive Surgery, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China
Biochem Biophys Res Commun 379:49-54. 2009The incidence of cholesterol gallstones is a very common disease. The aim of this study is to probe for underlying intestinal molecular defects associated with development of gallstones...
- Significant association of ABCG5 604Q and ABCG8 D19H polymorphisms with gallstone diseaseK K Kuo
Division of Hepatobiliopancreatic Surgery, Department of Surgery, Kaohsiung Medical University Hospital, Taiwan
Br J Surg 95:1005-11. 2008..The formation of gallstones, supersaturated with cholesterol in bile, is determined by genetic and environmental factors...
- Detection of common bile duct stones: comparison between endoscopic ultrasonography, magnetic resonance cholangiography, and helical-computed-tomographic cholangiographyShintaro Kondo
Department of Gastroenterology, Department of Radiology, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Japan
Eur J Radiol 54:271-5. 2005..We conducted this study to compare the diagnostic ability of EUS, MRCP, and HCT-C in patients with suspected choledocholithiasis...
- Sterol transporter adenosine triphosphate-binding cassette transporter G8, gallstones, and biliary cancer in 62,000 individuals from the general populationStefan Stender
Department of Clinical Biochemistry, Rigshospitalet, Copenhagen, Denmark
Hepatology 53:640-8. 2011..that ABCG8 (adenosine triphosphate-binding cassette transporter G8) Asp19His (D19H) genotype predicted risk of gallstones and biliary cancer in the general population, we studied 62,279 white individuals from The Copenhagen City Heart ..
- New pathophysiological concepts underlying pathogenesis of pigment gallstonesLibor Vitek
4th Department of Internal Medicine and Institute of Clinical Biochemistry and Laboratory Diagnostics, 1st Faculty of Medicine, Charles University of Prague, Prague, Czech Republic
Clin Res Hepatol Gastroenterol 36:122-9. 2012Pigment gallstones, which are much less frequent than cholesterol stones, are classified descriptively as "black" or "brown"...
- High cholesterol absorption efficiency and rapid biliary secretion of chylomicron remnant cholesterol enhance cholelithogenesis in gallstone-susceptible miceDavid Q H Wang
Department of Medicine, Harvard Medical School and Harvard Digestive Diseases Center, 330 Brookline Avenue, Boston, Massachusetts 02215, USA
Biochim Biophys Acta 1733:90-9. 2005..Differential metabolism of the chylomicron remnant cholesterol between C57L and AKR mice clearly plays a crucial role in the formation of lithogenic bile and gallstones.
- Large-scale identification of human biliary proteins from a cholesterol stone patient using a proteomic approachHu Zhou
Research Centre for Proteome Analysis, Key Lab of Proteomics, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, 200031, China
Rapid Commun Mass Spectrom 19:3569-78. 2005..Of the 218 proteins identified by 2D-LC/MS/MS, 92 were identified based on more than one unique tryptic peptide, and, of the total 222 proteins, 98 were identified based on more than one unique tryptic peptide...
- Biliary lipids and cholesterol gallstone diseaseDavid Q H Wang
Department of Medicine, Harvard Medical School, Liver Center and Gastroenterology Division, Beth Israel Deaconess Medical Center, and Harvard Digestive Diseases Center, and Brigham and Women s Hospital, Boston, MA 02115, USA
J Lipid Res 50:S406-11. 2009..summarizes current concepts of the physical-chemical state of biliary lipids in health and in lithogenic bile and outlines the molecular, genetic, hepatic, and cholecystic factors that underlie the pathogenesis of cholesterol gallstones.
- Effect of ezetimibe on the prevention and dissolution of cholesterol gallstonesHelen H Wang
Department of Medicine, Liver Center and Gastroenterology Division, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
Gastroenterology 134:2101-10. 2008..contributes to gallstone formation, we explored whether the potent cholesterol absorption inhibitor ezetimibe could prevent gallstones and promote gallstone dissolution in mice and reduce biliary cholesterol content in human beings.
- Endoscopic papillary balloon dilation vs. sphincterotomy for removal of common bile duct stones: a prospective randomized pilot studyJ C Arnold
Dept. of Medicine C, Ludwigshafen City Hospital, Ludwigshafen, Germany
Endoscopy 33:563-7. 2001..EST will therefore continue to be the standard procedure for stone removal in the near future. Further studies will be needed in order to compare the longer-term results with EST and EBD...
- Gallstone disease is associated with increased mortality in the United StatesConstance E Ruhl
Social and Scientific Systems, Inc, Silver Spring, Maryland 20910, USA
Gastroenterology 140:508-16. 2011b>Gallstones are common and contribute to morbidity and health care costs, but their effects on mortality are unclear...
- Statin use and the risk of cholecystectomy in womenChung Jyi Tsai
Division of Digestive Diseases and Nutrition, University of Kentucky Medical Center, Lexington, Kentucky 40536 0298, USA
Gastroenterology 136:1593-600. 2009..Statins also prevent the formation of gallstones in animal studies, although the effect of statins on human gallstone disease has been controversial.
- Metabolic syndrome as a risk factor for gallstone diseaseNahum Mendez-Sanchez
Department of Biomedical Research, Medica Sur Clinic and Foundation, Puente de Piedra 150, Col Toriello Guerra, Mexico City, Mexico
World J Gastroenterol 11:1653-7. 2005..To establish an association between the presence of metabolic syndrome and the development of gallstone disease...
- Increased gallstone risk in humans conferred by common variant of hepatic ATP-binding cassette transporter for cholesterolFrank Grunhage
Department of Internal Medicine I, University Hospital Bonn, Bonner Forum Biomedizin, Germany
Hepatology 46:793-801. 2007..In ASPs, gallstones were strongly linked to the D19H variant of the ABCG8 gene (NPL score = 7.1; P = 4.6 x 10(-13))...
- Molecular pathophysiology and physical chemistry of cholesterol gallstonesHelen H Wang
Department of Medicine, Liver Center and Gastroenterology Division, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
Front Biosci 13:401-23. 2008Cholesterol gallstones are one of the most prevalent and most costly digestive diseases in the developed countries...
- Variation of the gene encoding the nuclear bile salt receptor FXR and gallstone susceptibility in mice and humansPeter Kovacs
University of Leipzig, Department of Medicine III, Leipzig, Germany
J Hepatol 48:116-24. 2008..Here, we investigated further an association of the gene encoding FXR and gallstone susceptibility in mice and humans...
- Identification of cholelithogenic enterohepatic helicobacter species and their role in murine cholesterol gallstone formationKirk J Maurer
Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
Gastroenterology 128:1023-33. 2005..To test this, we prospectively investigated the effects of Helicobacter spp infection in cholesterol gallstone pathogenesis in the highly susceptible C57L/J mouse model...
- Increased expression of LXR alpha, ABCG5, ABCG8, and SR-BI in the liver from normolipidemic, nonobese Chinese gallstone patientsZhao Yan Jiang
Department of Surgery, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai Institute of Digestive Surgery, 200025 Shanghai, China
J Lipid Res 49:464-72. 2008..In the present study of Chinese patients with gallstones, we investigated whether this phenomenon was correlated with the hepatic expression of genes participating in ..
- Small sphincterotomy combined with papillary dilation with large balloon permits retrieval of large stones without mechanical lithotripsyAtsushi Minami
Kawasaki Kyodo Hospital 2 1 5 Sakuramoto Kawasaki City 210 0833, Japan
World J Gastroenterol 13:2179-82. 2007..To introduce a new method: small endoscopic sphincterotomy (ES) combined with endoscopic papillary large balloon dilation (SES + EPLBD) to treat patients with large biliary stones...
- Migrated endoclip and stone formation after cholecystectomy: a new danger of acute pancreatitisKemal Dolay
Bakirkoy Egitim ve Arastirma Hastanesi Genel Cerrahi Klinigi Endoskopi Unitesi Istanbul, Turkey
World J Gastroenterol 13:6446-8. 2007..The patient underwent early endoscopic retrograde cholangiopancreatography (ERCP) with endoscopic sphincterotomy and stone extraction...
- Timing of cholecystectomy after mild biliary pancreatitis: a systematic reviewMark C van Baal
Department of Operating Room Evidence Based Surgery, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
Ann Surg 255:860-6. 2012..To determine the risk of recurrent biliary events in the period after mild biliary pancreatitis but before interval cholecystectomy and to determine the safety of cholecystectomy during the index admission...
- Gallstone disease: Epidemiology, pathogenesis, and classification of biliary stones (common bile duct and intrahepatic)Susumu Tazuma
Department of General Medicine and Clinical Pharmacotherapeutics, Hiroshima University Hospital and Graduate School of Biomedical Sciences, 1 2 3, Kasumi, Hiroshima 734 8551, Japan
Best Pract Res Clin Gastroenterol 20:1075-83. 2006b>Gallstones are common in Western countries and Japan...
- Disruption of gallbladder smooth muscle function is an early feature in the development of cholesterol gallstone diseaseB Lavoie
Department of Anatomy and Neurobiology, University of Vermont School of Medicine, Burlington, VT 05405, USA
Neurogastroenterol Motil 24:e313-24. 2012..We studied a mouse model of gallstone disease to evaluate the development of GBSM dysfunction relative to changes in bile composition and the onset of sterile cholecystitis...
- Mice overexpressing hepatic Abcb11 rapidly develop cholesterol gallstonesAnne Henkel
Division of Hepatology, Department of Medicine, Northwestern University Feinberg School of Medicine, Tarry 14 711, 303 East Chicago Avenue, Chicago, Illinois, 60611, USA
Mamm Genome 16:903-8. 2005..This is likely because of increases in bile salt hydrophobicity but not because of alterations of other biliary lipid transporters. These findings strongly support Abcb11 as a Lith 1 gene...
- Polymorphisms of estrogen receptors and risk of biliary tract cancers and gallstones: a population-based study in Shanghai, ChinaSue K Park
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institute of Health, EPS MSC 7234, 6120 Executive Boulevard, Bethesda, MD 20892 7234, USA
Carcinogenesis 31:842-6. 2010..1). No association was found for ESR1 haplotype based on four SNPs. These preliminary results suggest that variants in ESR genes could play a role in the etiology of biliary tract cancers, especially bile duct cancer in men...
- Self-reported history of hypercholesterolaemia and gallstones and the risk of prostate cancerF Bravi
Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
Ann Oncol 17:1014-7. 2006..Although prostate cancer is one of the most common male cancers, its aetiology-and particularly the role of comorbidity-remains poorly understood...
- Helicobacter pylori and cholesterol gallstone formation in C57L/J mice: a prospective studyKirk J Maurer
Division of Comparative Medicine, Massachusetts Institute of Technology, 77 Massachusetts Ave, Cambridge, MA 02139, USA
Am J Physiol Gastrointest Liver Physiol 290:G175-82. 2006Recently, we demonstrated that cholesterol gallstone-prone C57L/J mice rarely develop gallstones unless they are infected with certain cholelithogenic enterohepatic Helicobacter species. Because the common gastric pathogen H...
- Epidemiology of gallstonesLaura M Stinton
Division of Gastroenterology, Department of Medicine, Faculty of Medicine, University of Calgary, Calgary, Alberta, Canada
Gastroenterol Clin North Am 39:157-69, vii. 2010b>Gallstones are common with prevalences as high as 60% to 70% in American Indians and 10% to 15% in white adults of developed countries...
- Gallstones are associated with carotid atherosclerosisNahum Mendez-Sanchez
Liver Unit, Medica Sur Clinica and Foundation, Mexico City, Mexico
Liver Int 28:402-6. 2008..Carotid atherosclerosis is an excellent marker of risk for CD like stroke and myocardial infarction. The aim of this study was to assess the association between gallstones and carotid atherosclerosis.
- Association between cholecystectomy for gallstone disease and risk factors for cardiovascular diseaseNorberto C Chavez-Tapia
Liver Research Unit, Medica Sur Clinic and Foundation, Mexico City
Ann Hepatol 11:85-9. 2012..The aim of this study is to analyse the relationship between cholecystectomy for gallstone disease and risk factors for cardiovascular disease...
- Genetic and functional identification of the likely causative variant for cholesterol gallstone disease at the ABCG5/8 lithogenic locusOliver von Kampen
Department of Internal Medicine I, Hospital Schleswig Holstein, Kiel, Germany
Hepatology 57:2407-17. 2013..Both the responsible variant and the molecular mechanism causing an increased incidence of gallstones in these patients have as yet not been identified...
- Significant role of estrogen and progesterone receptor sequence variants in gallbladder cancer predisposition: a multi-analytical strategyAnshika Srivastava
Department of Genetics, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India
PLoS ONE 7:e40162. 2012..Therefore the present study was designed to explore the role of genetic variants in estrogen (ESR1, ESR2) and progesterone (PGR) receptors in conferring risk of gallbladder cancer...
- EUS versus endoscopic retrograde cholangiography for patients with intermediate probability of bile duct stones: a prospective randomized trialTarkan Karakan
Department of Gastroenterology, Faculty of Medicine, Gazi University, Ankara, Turkey
Gastrointest Endosc 69:244-52. 2009..Factors affecting diagnostic accuracy and comparison of patients in the follow-up period for negative outcomes are not thoroughly investigated in a randomized trial...
- Endoscopic ultrasound versus endoscopic retrograde cholangiography for patients with intermediate probability of bile duct stones: a randomized trial comparing two management strategiesM Polkowski
Department of Gastroenterology, Medical Center for Postgraduate Education, Warsaw, Poland
Endoscopy 39:296-303. 2007..The assumption that such an approach is advantageous, however, has never been tested in a randomized trial...
- Strong association between gallstones and cardiovascular diseaseNahum Mendez-Sanchez
Department of Biomedical Research, Liver Unit Medica Sur Clinic and Foundation, Mexico City, Mexico
Am J Gastroenterol 100:827-30. 2005..We have investigated the association between GD and CHD in a cross-sectional study...
- Peritoneal gallstones following laparoscopic cholecystectomy: incidence, complications, and managementJ C Woodfield
HBP Upper GI Unit, Department of General Surgery, Auckland City Hospital, Park Road, 92024, Private Bag, Auckland, New Zealand
Surg Endosc 18:1200-7. 2004Gallstone spillage during laparoscopic cholecystectomy (LC) is a common intraoperative event. Although gallstones left in the peritoneal cavity were initially considered harmless, a significant number of complications have been reported...
- Cholesterol gallstones: a fellow traveler with metabolic syndrome?Scott M Grundy
Am J Clin Nutr 80:1-2. 2004
- [Epidemiology and gallstones]Torben Jørgensen
Forskningscenter for Forebyggelse og Sundhed, Amtssygehuset i Glostrup, Bygning 84 85, DK 2600 Glostrup
Ugeskr Laeger 167:2610-3. 2005b>Gallstones are more frequent in women than in men due to pregnancy...
- Reduced susceptibility to cholesterol gallstone formation in mice that do not produce apolipoprotein B48 in the intestineHelen H Wang
Department of Medicine, Liver Center and Gastroenterology Division, Beth Israel Deaconess Medical Center, Harvard Medical School and Harvard Digestive Diseases Center, Boston, MA 02215, USA
Hepatology 42:894-904. 2005It has been found that polymorphisms in the apolipoprotein (APO)-B gene are associated with cholesterol gallstones in humans...
- Effect of gallbladder hypomotility on cholesterol crystallization and growth in CCK-deficient miceHelen H Wang
Department of Medicine, Liver Center and Gastroenterology Division, Beth Israel Deaconess Medical Center, Harvard Medical School and Harvard Digestive Diseases Center, Boston, MA, USA
Biochim Biophys Acta 1801:138-46. 2010..At day 15 on the lithogenic diet, 75% of knockout mice formed gallstones. However, wild-type mice formed very little mucin gel, liquid, and solid crystals, and gallstones were not ..
- Pathogenesis of cholesterol and pigment gallstones: an updateKarel Johannes van Erpecum
Dept of Gastroenterology and Hepatology, University Medical Center Utrecht, HP F 02 618, PO Box 85500, 3508 GA Utrecht, The Netherlands
Clin Res Hepatol Gastroenterol 35:281-7. 2011..UDP)-glucuronosyltransferase 1A1) responsible for bilirubin conjugation were recently associated with risk of gallstones as well as stone bilirubin content, suggesting common factors in cholesterol and pigment gallstone pathogenesis.
- Gallstones and cholecystectomy in relation to risk of intra- and extrahepatic cholangiocarcinomaH Nordenstedt
Upper Gastrointestinal Research, Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden
Br J Cancer 106:1011-5. 2012..The aetiology is largely unknown, and the potential roles of gallstones and gall bladder removal (cholecystectomy) need to be addressed in a large study with a long follow-up.
- Evidence for oxidative stress in the gall bladder mucosa of gall stone patientsA Geetha
Post Graduate Department of Biochemistry, Bharathi Women s College Autonomous, North Chennai, Tamil Nadu, India
J Biochem Mol Biol Biophys 6:427-32. 2002..The resultant increased risk of bile saturation would further contribute to the progress of gall stone formation...
- Gallstones associated with nonalcoholic steatohepatitis (NASH) and metabolic syndromeOktay Yener
Department of Surgery, Goztepe Training and Research Hospital, Istanbul
Turk J Gastroenterol 21:411-5. 2010We aimed to evaluate the prevalence of non-alcoholic steatohepatitis and metabolic syndrome in patients with symptomatic gallstones undergoing laparoscopic or open cholecystectomy.
- Surgical treatment of gallstonesKurinchi S Gurusamy
Department of Surgery, University College London Medical School, Royal Free Hospital, London, UK
Gastroenterol Clin North Am 39:229-44, viii. 2010..Cholecystectomy cannot be recommended for any group of patients having asymptomatic gallstones except in those undergoing major upper abdominal surgery for other pathologies (grade B)...
- Genetic analysis of cholesterol gallstone formation: searching for Lith (gallstone) genesDavid Q H Wang
Liver Center, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, DA 601, Boston, MA 02215, USA
Curr Gastroenterol Rep 6:140-50. 2004..Because exceptionally close homology exists between mouse and human genomes, the orthologous human LITH genes can often be recognized after mouse genes are identified...
- The relationship between juxtapapillary duodenal diverticula and disorders of the biliopancreatic system: analysis of 350 patientsT Zoepf
Department of Gastroenterology, Academic Teaching Hospital, Ludwigshafen, Germany
Gastrointest Endosc 54:56-61. 2001..CONCLUSION: JPDD appears to be a risk factor for complications of endoscopic sphincterotomy and for gallbladder stones, bile duct stones, and their recurrence...
- Polymorphisms in ABCG5/G8 transporters linked to hypercholesterolemia and gallstone diseaseIwona Rudkowska
School of Dietetics and Human Nutrition, Faculty of Agricultural and Environmental Sciences, McGill University, Ste Anne de Bellevue, Quebec, Canada
Nutr Rev 66:343-8. 2008..plasma cholesterol to dietary and pharmaceutical interventions for hypercholesterolemia, and increased risk of gallstones. Clearly, the ABCG5 and ABCG8 genes play an important role in cholesterol homeostasis...
- Haplotype analysis of signal peptide (insertion/deletion) and XbaI polymorphisms of the APOB gene in gallbladder cancerSachchida Nand Pandey
Department of Genetics, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India
Liver Int 27:1008-15. 2007..We examined the effect of these polymorphisms individually as well as their haplotypes on GBC and gallstone patients in North Indian population...
- Endoscopic papillary large balloon dilation alone without sphincterotomy for the treatment of large common bile duct stonesHoi Hung Chan
Division of Gastroenterology, Department of Internal Medicine, Kaohsiung Veterans General Hospital, 386 Ta Chung 1st Road, Kaohsiung 81362, Taiwan
BMC Gastroenterol 11:69. 2011..Lethal pancreatitis has been reported after treatment for common bile duct stones using small endoscopic papillary balloon dilation...
- New insights into the molecular mechanisms underlying effects of estrogen on cholesterol gallstone formationHelen H Wang
Department of Medicine, Liver Center and Gastroenterology Division, Beth Israel Deaconess Medical Center, Harvard Medical School and Harvard Digestive Diseases Center, Boston, Massachusetts 02215, USA
Biochim Biophys Acta 1791:1037-47. 2009..and clinical studies have found that at all ages women are twice as likely as men to form cholesterol gallstones, and this gender difference begins since puberty and continues through the childbearing years, which highlight ..
- Variants in hormone-related genes and the risk of biliary tract cancers and stones: a population-based study in ChinaSue K Park
Department of Health and Human Services, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, 6120 Executive Boulevard, EPS 5024, MSC 7234, Bethesda, MD 20892 7234, USA
Carcinogenesis 30:606-14. 2009..Hormone-related factors, including parity, oral contraceptive use, obesity, and gallstones, have been implicated in the etiology of these cancers...
- Accuracy of linear endoscopic ultrasonography in the evaluation of patients with suspected common bile duct stonesM Kohut
Department of Gastroenterology, Silesian Medical Academy, Katowice, Poland
Endoscopy 34:299-303. 2002....
- Gallstone disease: from genes to evidence-based therapyFrank Lammert
Department Internal Medicine II, Saarland University Hospital, Saarland University, Kirrberger Str, 66421 Hamburg Saar, Germany
J Hepatol 48:S124-35. 2008..Here, we summarize the molecular and genetic mechanisms of gallstone formation as well as the current evidence-based algorithms for diagnosis and therapy of gallbladder and bile duct stones...
- Medical history and the risk of biliary tract cancers in Shanghai, China: implications for a role of inflammationGabriella Andreotti
Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Blvd, EPS 8011, MSC 7240, Bethesda, MD 20892, USA
Cancer Causes Control 22:1289-96. 2011..2-15.0) or duodenal ulcers (OR = 3.7, 1.2-12.0) was associated with an excess risk of gallbladder cancer. Although the mechanisms are unclear, our results further support the role for inflammation in the etiology of biliary tract cancers...
- Hereditary liver disease: gallstonesHenning Wittenburg
University of Leipzig, Department of Internal Medicine, Neurology and Dermatology, Division of Gastroenterology and Rheumatology, Liebigstr 20, 04103 Leipzig, Germany
Best Pract Res Clin Gastroenterol 24:747-56. 2010b>Gallstones are common in Western countries and due to pain and complications pose a substantial burden on health care systems. In general, cholesterol gallstones are distinguished from bilirubin gallstones...
- Association of periampullary diverticula with primary choledocholithiasis but not with secondary choledocholithiasisM H Kim
Dept of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea
Endoscopy 30:601-4. 1998..The aims of our study are to evaluate the association between periampullary diverticula and gallstones according to their site and to clarify the origin of the common bile duct stones by analyzing their composition.
- Gallstones: environment, lifestyle and genesCaroline S Stokes
Department of Medicine II, Saarland University Hospital, Homburg, Germany
Dig Dis 29:191-201. 2011..5 billion in the United States. The paradigm of environmental risk factors for gallstones has lately been challenged by genetic studies in experimental models and humans...
- Incidence and risk factors for gallstones in patients with inflammatory bowel disease: a large case-control studyFabrizio Parente
Gastrointestinal Unit, A Manzoni Hospital, Lecco, and the Gastroenterology Unit, L Sacco University Hospital, Milan, Italy
Hepatology 45:1267-74. 2007The risk for gallstones (GD) in inflammatory bowel diseases and the factors responsible for this complication have not been well established...
- Cholesterol gallstones and cancer of gallbladder (CAGB): molecular linksAjit Venniyoor
Department of Medicine and Medical Oncology, INHS Asvini, Near RC Church, Colaba, Mumbai Bombay, Maharastra 400 005, India
Med Hypotheses 70:646-53. 2008There is a known association between cholesterol gallstones and cancer of gall bladder (CAGB). However, the exact relation is not clear...
- [Gallstone biochemical characteristics using Fourier transform infrared spectroscopy method]P Sossé Djessou
Laboratoire de Biochimie Medicale, UFR des sciences médicales, Abidjan, Cote d Ivoire
Ann Biol Clin (Paris) 68:39-42. 2010This study reports biochemical composition and morphological aspect of gallstones as investigated by spectroscopy IR method...
- Endoscopic management of bile duct stonesK F Binmoeller
Department of Medicine and Surgery, University of California, San Diego 92103 8413, USA
J Clin Gastroenterol 32:106-18. 2001..Primary laparoscopic evaluation and management is reasonable in patients who have a low-to-moderate probability of having CBD stones...
- Genetic variants involved in gallstone formation and capsaicin metabolism, and the risk of gallbladder cancer in Chilean womenSergio Baez
Division of Social and Environmental Medicine, Department of Community Preventive Medicine, Niigata University Graduate School of Medical and Dental Sciences, 1 757 Asahimachi dori, Chuo Ku, Niigata 951 8510, Japan
World J Gastroenterol 16:372-8. 2010..To determine the effects of genetic variants associated with gallstone formation and capsaicin (a pungent component of chili pepper) metabolism on the risk of gallbladder cancer (GBC)...
- Increased susceptibility to diet-induced gallstones in liver fatty acid binding protein knockout miceYan Xie
Department of Medicine, Division of Gastroenterology, Washington University School of Medicine, St Louis, MO 63110, USA
J Lipid Res 50:977-87. 2009..Seventy-five percent of L-Fabp(-/-) mice developed solid gallstones compared with 6% of wild-type mice with an increased gallstone score (3.29 versus 0.62, respectively; P < 0...
- Association of APOE-C1 gene cluster polymorphisms with gallstone diseaseM Dixit
Department of Medical Genetics, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Raebareli Road, Lucknow 226014, India
Dig Liver Dis 38:397-403. 2006..Genetic polymorphisms in apolipoprotein genes may be associated with alteration in lipid profile and susceptibility to gallstone disease...
- Gallstones and the risk of biliary tract cancer: a population-based study in ChinaA W Hsing
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20852 7234, USA
Br J Cancer 97:1577-82. 2007..Among controls, a transabdominal ultrasound was performed to detect asymptomatic gallstones. Gallstones removed from cancer cases and gallstone patients were classified by size, weight, colour, pattern, ..
- Physical activity reduces the risk of symptomatic gallstones: a prospective cohort studyPaul J R Banim
Norfolk and Norwich University Hospital NHS Trust, University of East Anglia, Norwich, UK
Eur J Gastroenterol Hepatol 22:983-8. 2010Physical activity may prevent gallstones formation by reducing bile stasis and plasma triglycerides and elevating high-density lipoprotein cholesterol levels...
- Statin use and risk of gallstone disease followed by cholecystectomyMichael Bodmer
Division of Clinical Pharmacology and Toxicology, University Hospital, Basel, Switzerland
JAMA 302:2001-7. 2009..Statins decrease hepatic cholesterol biosynthesis and may therefore lower the risk of cholesterol gallstones by reducing the cholesterol concentration in the bile. Data on this association in humans are scarce.
- Polymorphism of genes related to insulin sensitivity and the risk of biliary tract cancer and biliary stone: a population-based case-control study in Shanghai, ChinaShih Chen Chang
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, DHHS, Bethesda, MD 20892, USA
Carcinogenesis 29:944-8. 2008..Obesity and gallstones, both related to insulin resistance, are linked to an elevated risk of biliary cancer...
- Sequential endoscopic papillary balloon dilatation following limited sphincterotomy for common bile duct stonesRakesh Kochhar
Department of Gastroenterology, Postgraduate Institute of Medical Education and Research, Chandigarh, 160012, India
Dig Dis Sci 54:1578-81. 2009..One patient had impaction of the dormia basket. We conclude that EPBD following EST is safe and effective in removing stones > or = 10 mm in size in over 90% of patients...
- Biliary lipids, water and cholesterol gallstonesKarel J van Erpecum
Department of Gastroenterology, University Hospital Utrecht, Utrecht, The Netherlands
Biol Cell 97:815-22. 2005..The remaining unstable cholesterol-enriched vesicles may nucleate crystals. Various aquaporins have recently been discovered throughout the biliary tract, with potential relevance for gallstone formation...
- Gallstones and Clonorchis sinensis infection: a hospital-based case-control study in KoreaDongil Choi
Department of Radiology and Center for Imaging Science, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
J Gastroenterol Hepatol 23:e399-404. 2008..The authors conducted a hospital-based case-control study to evaluate the role of Clonorchis sinensis infection as a risk factor for the development of gallstones in Korea.
- Gallstones and gallbladder cancer-volume and weight of gallstones are associated with gallbladder cancer: a case-control studyIvan Roa
Department of Pathology, Faculty of Medicine Universidad de la Frontera, Temuco, Chile
J Surg Oncol 93:624-8. 2006b>Gallstones are considered the most important risk factor for gallbladder cancer.
- Risk factors for acute pancreatitis after endoscopic papillary balloon dilationMasanori Sugiyama
First Department of Surgery, Kyorin University School of Medicine, 6 20 2 Shinkawa, Mitaka, Tokyo 181 8611, Japan
Hepatogastroenterology 50:1796-8. 2003..Although EPBD (endoscopic papillary balloon dilation) may cause acute pancreatitis, risk factors for post-EPBD pancreatitis have not been well described. We retrospectively analyzed risk factors predictive of acute pancreatitis after EPBD...
- Can endoscopic papillary balloon dilation really preserve sphincter of Oddi function?I Yasuda
First Department of Internal Medicine, Gifu University School of Medicine, Gifu, Japan
Gut 49:686-91. 2001..However, few studies have addressed this issue specifically. In this study, we investigated whether EPBD can preserve sphincter function, and evaluated whether or not such preservation has clinical significance...
- Serum lipid levels and the risk of biliary tract cancers and biliary stones: A population-based study in ChinaGabriella Andreotti
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, DHHS, Bethesda, MD, USA
Int J Cancer 122:2322-9. 2008..b>Gallstones, the predominant risk factor for biliary cancers, are linked with hyperlipidemia...
- Pathogenesis of gallstonesNiels Gerard Venneman
Department of Gastroenterology and Hepatology, University Medical Center Utrecht, Utrecht, The Netherlands
Gastroenterol Clin North Am 39:171-83, vii. 2010..Hydrophobic bile salt pool, bile concentration, excess pronucleating mucin, and impaired gallbladder and intestinal motility are secondary phenomena in most cases but nevertheless may contribute to gallstone formation...
- Polymorphisms at cholesterol 7alpha-hydroxylase, apolipoproteins B and E and low density lipoprotein receptor genes in patients with gallbladder stone diseaseZhao Yan Jiang
Department of Surgery, Ruijin Hospital, Shanghai Second Medical University, Shanghai 200025, China
World J Gastroenterol 10:1508-12. 2004....
- Endoscopic balloon dilation of the biliary sphincter compared to endoscopic biliary sphincterotomy for removal of common bile duct stones during ERCP: a metaanalysis of randomized, controlled trialsTodd H Baron
Department of Medicine, Division of Gastroenterology and Hepatology, Mayo Medical Center, Rochester, Minnesota, USA
Am J Gastroenterol 99:1455-60. 2004..To compare the effect of endoscopic balloon dilation (EPBD) of the papilla with that of endoscopic biliary sphincterotomy (EST) in the treatment of patients with common bile duct stones...
- Risk factors for recurrence of primary bile duct stones after endoscopic biliary sphincterotomyD I Kim
Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea
Gastrointest Endosc 54:42-8. 2001....
- Lost gallstones in laparoscopic cholecystectomy: all possible complicationsJörg Zehetner
Department of Surgery, Ludwig Boltzmann Institute for Operative Laparoscopy, AKH Linz, Krankenhausstrasse 9, 4020 Linz, Austria
Am J Surg 193:73-8. 2007Laparoscopic cholecystectomy (LC) has been the gold standard for symptomatic gallstones for 15 years. During that time, several studies and case reports have been published which outline the possible complications of lost gallstones...
- Balloon sphincteroplasty for removing difficult bile duct stonesA Maydeo
Institute of Advanced Endoscopy, Mumbai, India
Endoscopy 39:958-61. 2007..The aim of this study was to evaluate the efficacy and safety of papillary balloon dilation after sphincterotomy for extraction of these difficult-to-remove bile duct stones...
- Roles of infection, inflammation, and the immune system in cholesterol gallstone formationKirk J Maurer
Division of Gastroenterology, Brigham and Women s Hospital, Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA
Gastroenterology 136:425-40. 2009..Until recently, the role of the immune system in the pathogenesis of cholesterol gallstones was not considered a valid topic of research interest...
- Diabetes in relation to biliary tract cancer and stones: a population-based study in Shanghai, ChinaF M Shebl
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institute of Health, Bethesda, MD, USA
Br J Cancer 103:115-9. 2010..Biliary tract cancers are rare but fatal malignancies. Diabetes has been related to biliary stones, but its association with biliary tract cancers is less conclusive...
- Promotion of PDT Induced phototoxicity by bile acidsDavid Kessel; Fiscal Year: 2003..These results are of potentially great clinical significance since UDCA is widely used for the treatment of gallstones and liver diseases, and its pharmacology and safety have been well established...
- Regulation of Metabolism by Dietary SterolsSHAILENDRA BHANUBHAI PATEL; Fiscal Year: 2013..Some data from animal studies indicate improvement in atherosclerosis, but aggravation of stroke. These studies are important because they may help guide nutritional advice for a very large proportion of the patient population. ..
- Gallstone Pancreatitis: Pathogenesis and TreatmentIsaac Samuel; Fiscal Year: 2012..The commonest cause of acute pancreatitis world-wide is gallstones. This research proposal investigates how gallstone obstruction of the pancreatic duct may initiate acute ..
- Therapeutic Potential of PARP inhibitor for Acute PancreatitisLatha Paka; Fiscal Year: 2010..The most common causes of AP is the presence of gallstones and heavy alcohol (60%-80%) use that cause inflammation and necrosis of the pancreas...
- Role of Bile Acids and Gut Bacteria in GI DiseasesPhillip B Hylemon; Fiscal Year: 2013..give us the tools to carry out clinical studies to determine the most effective ways to decrease DCA in the bile acid pool with the aim of decreasing the risk of colon cancer and cholesterol gallstones, in some patients.
- ALIMENTARY TRACT LIPIDS IN HEALTH AND DISEASEMARTIN CONRAD CAREY; Fiscal Year: 2013..techniques to advance fundamental understanding of bile and its two major dysfunctions, namely cholestasis and gallstones of both pigment and cholesterol types, i) The first aim will determine whether enterohepatic infection with ..
- Genetic influences in experimental pancreatitisBishr Omary; Fiscal Year: 2013..The majority of acute pancreatitis cases are related to alcohol or gallstones. Chronic pancreatitis, which results in progressive fibrosis and loss of parenchyma, is generally secondary to ..
- Hepatic Fatty Acid Metabolism and SteatosisNICHOLAS DAVIDSON; Fiscal Year: 2013..We demonstrate that L-Fabp-/- mice are dramatically more susceptible to lithogenic diet (LD)-induced gallstones compared to C57BL/6 congenic controls with a phenotype including increased serum and hepatic free cholesterol, ..
- Control of lipid metabolism in insulin resistant statesSudha B Biddinger; Fiscal Year: 2013..derangements in lipid homeostasis, leading to dyslipidemia, atherosclerosis, hepatic steatosis, and cholesterol gallstones. The factors that drive these derangements are unknown but must be determined in order to effectively treat the ..
- Development of an HTS assay to identify FXR antagonistsThomas P Burris; Fiscal Year: 2010..FXR has been implicated as a drug target for the treatment of dyslipidemia (atheroscelerosis), diabetes, and gallstones. Although a few synthetic agonists have been identified for FXR, no selective antagonists have yet been ..
- REGULATION OF CHOLESTEROL METABOLISMShunlin Ren; Fiscal Year: 2010..Loss of cholesterol homeostasis causes diseases, such as atherosclerosis and cholesterol gallstones. Atherosclerosis and its clinical sequelae are a major cause of premature death and disability in the United ..
- Tissue specific mechanism of FXR in suppressing bile-acid synthesisGrace L Guo; Fiscal Year: 2011..FXR dysfunction contributes to the development of cholestasis, gallstones, fatty-liver disease, and liver tumor...
- The role of cigarette smoke toxin and alcohol in pancreatitisEdwin C Thrower; Fiscal Year: 2013..It is most often caused by gallstones and alcohol abuse...
- Protein-Crystal Molecular Recognition in BiomineralizationPatrick S Stayton; Fiscal Year: 2012..g. gingivitis) development. ..
- The role of T-cells and Th 1 immunity in cholesterol gallstonesKIRK JAMES MAURER; Fiscal Year: 2011Cholesterol gallstones are a common costly disease with a complex incompletely understood pathogensesis [sic] involving genetic and environmental contributions...
- INTRACELLULAR TRANSPORT OF AMPHIPATHSBruce Luxon; Fiscal Year: 2000..crucial information needed to explain the pathogenesis of diseases as diverse as atherosclerosis, obesity, and gallstones. Insights and new methods developed in this proposal may apply to the intracellular transport of other ..
- PHYSICAL CHEMISTRY OF BILIRUBIN & ITS CONJUGATESWILLIAM SPIVAK; Fiscal Year: 1990..derivatives of UCB (calcium bilirubinate or bilirubin polymers) make up part of the nidus of most cholesterol gallstones and are essential parts of the matrix of pigment gallstones, biliary sludge and the insoluble bile pigment ..
- The Interaction Between Hepatic Insulin Resistance and Cholesterol MetabolismSudha B Biddinger; Fiscal Year: 2010..Biddinger, focusing on the liver, will examine the molecular links between insulin resistance, dyslipidemia and gallstones, three features of the metabolic syndrome, and how they are modified by dietary factors...
- THE UNSUSPECTED SMALL STONE STUDY (USSS)James DiSario; Fiscal Year: 2000DESCRIPTION (adapted from the application) Gallstones are the most common and the most costly digestive disease, with an annual estimated expenditure of 5 billion dollars...
- THE METABOLISM OF STEROLS FROM SHELLFISH AND ALGAEWILLIAM CONNOR; Fiscal Year: 1980..of cholesterol? Would they be hypocholesterolemic? Are these sterols or their derivatives found in bile, gallstones and atherosclerotic plaques? What is the origin of these different sterols, particularly in shellfish, ..
- ROLE OF THE GALLBLADDER IN PATHOGENESIS OF GALLSTONESLESTER WILLIAMS; Fiscal Year: 1991b>Gallstones (GS) are a significant health problem with cholecystectomy the most common abdominal operation in many hospitals...
- PRODUCTION OF URSODIOL FROM TURKEY BILETibor Sipos; Fiscal Year: 1991..Ursodiol is medically used to dissolve gallstones. Ursodiol is very expensive ($800-$2000/kg) and only produced by companies outside the USA...
- Role of Nrf2 during cholestsis and gallstone formationANGELA SLITT; Fiscal Year: 2009..b>Gallstones can cause extrahepatic cholestasis by occluding the common bile duct...
- Biliary oxysterols and cholangiocarcinomaRAHUL P KUVER; Fiscal Year: 2010..The presence and abundance of oxysterols in human bile and gallstones correlated with the presence of bacterial infection, and with the amount of bacterial DMA present in the stones...
- MYOGENIC DISORDERS OF THE GALLBLADDERJose Behar; Fiscal Year: 2004..These studies will be conducted in dissociated muscle cells from human GB's with gallstones with or without AC and from experimental AC induced by ligation of the common bile duct in animals with normal ..
- GALLSTONE FORMATION & PREVENTION DURING WEIGHT REDUCTIONJAY MARKS; Fiscal Year: 1991We recently have found that obese patients rapidly losing weight develop cholesterol gallstones frequently (26% incidence) and rapidly (in less than 4 months)...
- ROLE OF CALCIUM AND CAFFEINE IN GALLSTONE DISEASEKeith Lillemoe; Fiscal Year: 1993..dietary calcium and caffeine, two important components of the American diet, in pathogenesis and prevention of gallstones. Our hypothesis for this proposal are that oral calcium supplementation promotes gallstone formation and that ..
- Host-Microbial Control of Deoxycholate ProductonPaul Dawson; Fiscal Year: 2005..deoxycholate production is a positive risk factor for the development of colon cancer as well as cholesterol gallstones. However, the factors that regulate deoxycholate production are poorly understood...
- NOVEL ERYTHROMYCIN ANALOGS FOR GI MOTILITY DISORDERSChristopher Carreras; Fiscal Year: 2000..disorders such as gastroesophogeal reflux disease (GERD), gastroparesis, postoperative ileus, scleroderma, gallstones, and as a quick and effective drug to stimulate stomach emptying in patients requiring emergency surgery...
- MECHANISM OF ESTROGEN EFFECTS ON BILIARY CHOLESTEROLFRED KERN; Fiscal Year: 1991Cholesterol gallstones, a common and costly disease, occurs 2.5 times as frequently in women as in men, and its incidence is doubled again by contraceptive steroids (CS) or postmenopausal estrogen...
- Role of Gallbladder Ion Transport in Gallstone FormationA Moser; Fiscal Year: 2006..biology and instilled a strong desire to become a clinician scientist and an innovator in the treatment of gallstones. To develop his research career, the candidate needs significantly more time for scientific pursuits as well as ..
- HYPERBILIRUBINEMIA TREATMENT WITH CLONED THERMO-ENZYMESLarry Allen; Fiscal Year: 1993..An additional potential use is the development of minimally invasive treatment for pigmented gallstones. In Phase I, the feasibility of the project was successfully shown by identifying six thermophilic organisms ..
- Role of ABCG5 and ABCG8 in Sterol MetabolismHelen Hobbs; Fiscal Year: 2007..human diseases: coronary atherosclerosis, the leading cause of death in the Western societies, and cholesterol gallstones, one of the leading indicators for surgery in the United States...
- Abcb11 and Hepatic TransportAnne Henkel; Fiscal Year: 2009..Cholelithiasis is a major health problem affecting over 20 million Americans annually. A family history of gallstones has been identified as a strong risk factor for the development of gallstones, suggesting a genetic basis to ..
- OBESITY, LEPTIN AND GALLSTONE PATHOGENESISHenry Pitt; Fiscal Year: 2005DESCRIPTION (Verbatim from Applicant's Abstract): Approximately 30,000,000 Americans have gallstones, and the vast majority are overweight...
- Gender Differences in Gallstone PathogenesisMOHAMMAD ABEDIN; Fiscal Year: 2006..Female sex hormones have been implicated as contributory factors to the promotion of gallstones. Female sex hormones promote gallstone formation by increasing biliary cholesterol saturation and gallbladder ..
- MUCIN AND TREFOIL PROTEINS IN GALLSTONE PATHOGENESISDavid Nunes; Fiscal Year: 1999..formation, mucin accelerates cholesterol nucleation and crystal growth and forms the scaffold on which mature gallstones are built...
- MUCIN AND NON-MUCIN PROTEINS IN GALLSTONE PATHOGENESISGwynneth Offner; Fiscal Year: 2000..The overall goal of this project is to understand the role of gallbladder mucin in the pathogenesis of cholesterol gallstones. Medical or surgical treatment for symptomatic gallstones is a frequent cause for hospitalization in the United ..
- DIET & LIPOPROTEIN INDUCED EFFECTS ON BILE SECRETIONMartin Scobey; Fiscal Year: 1990..The dietary perturbations employed will take advantage of the greater occurence of cholesterol gallstones seen in this species when animals are fed diets with increasing amounts of cholesterol and polyunsaturated fat...
- Jaundice Chip: Diagnostic tool for cholestatic liver disJorge Bezerra; Fiscal Year: 2006..same genes also cause debilitating liver diseases or increase susceptibility to common biliary diseases, such as gallstones. Despite the remarkable progress in understanding how these genes cause liver disease in humans, the new ..
- The Role of Nitric Oxide in Cholesterol HomeostasisMelanie Ihrig; Fiscal Year: 2003..Prolonged intestinal transit time augments formation of cholesterol gallstones, and if prolonged intestinal transit time is the underlying cause of hypercholesterolemia in iNOS-deficient mice,..
- PROTEIN LIPID INTERACTIONS IN GALLSTONE PATHOGENESISNezam Afdhal; Fiscal Year: 2002..formation and this proposal will examine the mechanism by which mucin interacts with biliary lipids to promote gallstones. The specific Aims are to 1) Characterize the interaction of specific sites of the mucin molecule with lipid ..
- SECOND MESSENGERS, GALLBLADDER ABSORPTION AND GALLSTONESMOHAMMAD ABEDIN; Fiscal Year: 2001DESCRIPTION: (Adapted from investigator's abstract) The development of cholesterol gallstones involves alterations in the relationship of the amount of cholesterol, phospholipid and bile salts present in bile resulting in bile becoming ..
- Consomic Strains Between C57BL/6 and PWDLeah Rae Donahue; Fiscal Year: 2006..growth and fertility, sleep disorders, lung function, kidney function, obesity, diabetes, atherosclerosis, gallstones, hematology, osteoporosis, neurological function, immunologic function, hearing, sight, learning, memory, and ..
- DIETARY INFLUENCE ON GALLSTONESKENNETH HAYES; Fiscal Year: 1993Cholesterol gallstones are a serious and expensive complication of the Western diet, commonly occurring in overweight women consuming too many calories and expressing a high plasma lipid, hyperinsulinemic profile...
- Cholesterol Nanodomain Formation in Lipid MembranesSTEVEN WRENN; Fiscal Year: 2009..Cholesterol crystals are precursors to gallstones;inhibiting cholesterol nucleation offers a potential means of preventing stones...
- GENETIC DETERMINANTS OF CHOLESTEROL GALLSTONES IN MICEBeverly Paigen; Fiscal Year: 2005..Identifying the full range of QTLs that lead to gallstone disease in the mouse will position the field of cholesterol gallstone research to take advantage of the large genomic sequencing efforts currently underway. ..
- Epidemiology of hepatocellular carcinomaCynthia Ko; Fiscal Year: 2006....
- A Primary-Care Based Colorectal Cancer Screening ProgramCynthia Ko; Fiscal Year: 2006..If successful, this program may be useful to other large primary care practices, and may also help to improve utilization of other types of cancer prevention services ..
- The effect of physical activity on metabolic syndrome in pregnancy and fetal outcCynthia Ko; Fiscal Year: 2008..It may offer a safe and readily available method to control weight and improve infant health during and after pregnancy. [unreadable] [unreadable] [unreadable]..
- Colonoscopy quality and outcomes in clinical practiceCynthia W Ko; Fiscal Year: 2010..The various algorithms we develop will be tested in a second, validation subset of our database to find the algorithm with optimal performance characteristics. ..
- Role of CCK Receptor in Acute Pancreatitis PathogenesisIsaac Samuel; Fiscal Year: 2007..James W. Maher, MD, Director, Division of Gastrointestinal Surgery, University of Iowa College of Medicine, Iowa City.  PHS 398/2590 (Rev. 05/01) Page__ 26 Continuation Format Page  ..