gallstones

Summary

Summary: Solid crystalline precipitates in the BILIARY TRACT, usually formed in the GALLBLADDER. Gallstones, derived from the BILE, consist mainly of calcium, cholesterol, or bilirubin.

Top Publications

  1. ncbi Genetic and environmental influences on symptomatic gallstone disease: a Swedish study of 43,141 twin pairs
    Despina Katsika
    Department of Medicine at Karolinska University Hospital Huddinge, Karolinska Institutet, Stockholm, Sweden
    Hepatology 41:1138-43. 2005
  2. ncbi Gallstone disease
    H U Marschall
    Department of Medicine, Karolinska Institutet, Karolinska University Hospital, Huddinge, Stockholm, Sweden
    J Intern Med 261:529-42. 2007
  3. ncbi Cholesterol gallstone disease
    Piero Portincasa
    Department of Internal and Public Medicine, University Medical School, Bari, Italy
    Lancet 368:230-9. 2006
  4. ncbi Cholesterol metabolism gene polymorphisms and the risk of biliary tract cancers and stones: a population-based case-control study in Shanghai, China
    Hong Li Xu
    Department of Epidemiology, Cancer Institute of Shanghai Jiao Tong University, China
    Carcinogenesis 32:58-62. 2011
  5. pmc Predictors of gallstone composition in 1025 symptomatic gallstones from Northern Germany
    Clemens Schafmayer
    Department of General and Thoracic Surgery, University Hospital Schleswig Holstein, Campus Kiel, Arnold Heller Str 7, D 24105 Kiel, Germany
    BMC Gastroenterol 6:36. 2006
  6. pmc Gallstones play a significant role in Salmonella spp. gallbladder colonization and carriage
    Robert W Crawford
    Department of Molecular Virology, Center for Microbial Interface Biology, The Ohio State University, Columbus, OH 43210, USA
    Proc Natl Acad Sci U S A 107:4353-8. 2010
  7. ncbi Prevention of cholesterol gallstone disease by FXR agonists in a mouse model
    Antonio Moschetta
    Howard Hughes Medical Institute and Department of Pharmacology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390 9050, USA
    Nat Med 10:1352-8. 2004
  8. ncbi Gallstone disease in Swedish twins: risk is associated with ABCG8 D19H genotype
    D Katsika
    Karolinska Institutet, Department of Medicine, Division of Gastroenterology and Hepatology, Karolinska University Hospital Huddinge, Stockholm, Sweden
    J Intern Med 268:279-85. 2010
  9. ncbi Role of ABCG8 D19H (rs11887534) variant in gallstone susceptibility in northern India
    Anshika Srivastava
    Departments of Genetics, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India
    J Gastroenterol Hepatol 25:1758-62. 2010
  10. ncbi Dissecting the genetic heterogeneity of gallbladder stone formation
    Marcin Krawczyk
    Department of Medicine II, Saarland University Hospital, Homburg, Germany
    Semin Liver Dis 31:157-72. 2011

Research Grants

  1. Promotion of PDT Induced phototoxicity by bile acids
    David Kessel; Fiscal Year: 2003
  2. Regulation of Metabolism by Dietary Sterols
    SHAILENDRA BHANUBHAI PATEL; Fiscal Year: 2013
  3. Gallstone Pancreatitis: Pathogenesis and Treatment
    Isaac Samuel; Fiscal Year: 2012
  4. Therapeutic Potential of PARP inhibitor for Acute Pancreatitis
    Latha Paka; Fiscal Year: 2010
  5. Role of Bile Acids and Gut Bacteria in GI Diseases
    Phillip B Hylemon; Fiscal Year: 2013
  6. ALIMENTARY TRACT LIPIDS IN HEALTH AND DISEASE
    MARTIN CONRAD CAREY; Fiscal Year: 2013
  7. Genetic influences in experimental pancreatitis
    Bishr Omary; Fiscal Year: 2013
  8. Hepatic Fatty Acid Metabolism and Steatosis
    NICHOLAS DAVIDSON; Fiscal Year: 2013
  9. Control of lipid metabolism in insulin resistant states
    Sudha B Biddinger; Fiscal Year: 2013
  10. Development of an HTS assay to identify FXR antagonists
    Thomas P Burris; Fiscal Year: 2010

Detail Information

Publications317 found, 100 shown here

  1. ncbi Genetic and environmental influences on symptomatic gallstone disease: a Swedish study of 43,141 twin pairs
    Despina Katsika
    Department of Medicine at Karolinska University Hospital Huddinge, Karolinska Institutet, Stockholm, Sweden
    Hepatology 41:1138-43. 2005
    ..In conclusion, our results show heritability to be a major susceptibility factor for symptomatic gallstone disease, consistent with results from previous, much smaller studies...
  2. ncbi Gallstone disease
    H U Marschall
    Department of Medicine, Karolinska Institutet, Karolinska University Hospital, Huddinge, Stockholm, Sweden
    J Intern Med 261:529-42. 2007
    ..Aetiology and pathogenesis of cholesterol gallstones still are not well defined, and strategies for prevention and efficient nonsurgical therapies are missing...
  3. ncbi Cholesterol gallstone disease
    Piero Portincasa
    Department of Internal and Public Medicine, University Medical School, Bari, Italy
    Lancet 368:230-9. 2006
    With a prevalence of 10-15% in adults in Europe and the USA, gallstones are the most common digestive disease needing admission to hospital in the West...
  4. ncbi Cholesterol metabolism gene polymorphisms and the risk of biliary tract cancers and stones: a population-based case-control study in Shanghai, China
    Hong Li Xu
    Department of Epidemiology, Cancer Institute of Shanghai Jiao Tong University, China
    Carcinogenesis 32:58-62. 2011
    Biliary tract cancers are rare but fatal malignancies, with increasing incidence in Shanghai, China. Gallstones, the primary risk factor for biliary tract cancer, typically result from oversaturation of cholesterol in bile...
  5. pmc Predictors of gallstone composition in 1025 symptomatic gallstones from Northern Germany
    Clemens Schafmayer
    Department of General and Thoracic Surgery, University Hospital Schleswig Holstein, Campus Kiel, Arnold Heller Str 7, D 24105 Kiel, Germany
    BMC Gastroenterol 6:36. 2006
    b>Gallstones represent a prevalent and costly health problem. The changing epidemiology and the emerging non-surgical interventions for gallstone disease necessitate the definition of target populations for future therapies...
  6. pmc Gallstones play a significant role in Salmonella spp. gallbladder colonization and carriage
    Robert W Crawford
    Department of Molecular Virology, Center for Microbial Interface Biology, The Ohio State University, Columbus, OH 43210, USA
    Proc Natl Acad Sci U S A 107:4353-8. 2010
    ..the gallbladder and persist in an asymptomatic carrier state that is frequently associated with the presence of gallstones. We have shown that salmonellae form bile-mediated biofilms on human gallstones and cholesterol-coated surfaces ..
  7. ncbi Prevention of cholesterol gallstone disease by FXR agonists in a mouse model
    Antonio Moschetta
    Howard Hughes Medical Institute and Department of Pharmacology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390 9050, USA
    Nat Med 10:1352-8. 2004
    ..Taken together, these results indicate that FXR is a promising therapeutic target for treating or preventing cholesterol gallstone disease...
  8. ncbi Gallstone disease in Swedish twins: risk is associated with ABCG8 D19H genotype
    D Katsika
    Karolinska Institutet, Department of Medicine, Division of Gastroenterology and Hepatology, Karolinska University Hospital Huddinge, Stockholm, Sweden
    J Intern Med 268:279-85. 2010
    ..We investigated these polymorphisms in Swedish twins by merging the Swedish Twin Registry with the Hospital Discharge and Causes of Death Registries for gallstone disease-related diagnoses...
  9. ncbi Role of ABCG8 D19H (rs11887534) variant in gallstone susceptibility in northern India
    Anshika Srivastava
    Departments of Genetics, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India
    J Gastroenterol Hepatol 25:1758-62. 2010
    ..We aimed to examine the role of the ABCG8 D19H (rs11887534) polymorphism in susceptibility to gallstone disease in the northern Indian population...
  10. ncbi Dissecting the genetic heterogeneity of gallbladder stone formation
    Marcin Krawczyk
    Department of Medicine II, Saarland University Hospital, Homburg, Germany
    Semin Liver Dis 31:157-72. 2011
    ..cholesterol transporter ABCG5/G8 and the bilirubin conjugating enzyme UGT1A1, as major genetic determinants of gallstones in humans...
  11. ncbi Gallstone disease: Epidemiology of gallbladder stone disease
    Eldon A Shaffer
    Division of Gastroenterology, Health Science Centre, University of Calgary, 3330 Hospital Dr SW, Calgary, Alberta T2N4N1, Canada
    Best Pract Res Clin Gastroenterol 20:981-96. 2006
    ..Ten to fifteen per cent of white adults in developed countries harbour gallstones. Frequency is further reduced in Black Americans, East Asia and sub-Saharan Africa...
  12. ncbi Endoscopic balloon dilation compared with sphincterotomy for extraction of bile duct stones
    James A Disario
    Division of Gastroenterology, Hepatology and Nutrition, University of Utah Health Science Center, Salt Lake City, UT 84132, USA
    Gastroenterology 127:1291-9. 2004
    ..The aim of this study was to determine short-term outcomes of endoscopic balloon dilation of the sphincter of Oddi compared with sphincterotomy for stone extraction...
  13. ncbi Development of symptoms and complications in individuals with asymptomatic gallstones
    I Halldestam
    Department of Surgery, University Hospital of Linkoping, SE 58185 Linkoping, Sweden
    Br J Surg 91:734-8. 2004
    Gallbladder stones are common in the developed world. Complications of gallstones contribute substantially to healthcare costs and may be life threatening...
  14. pmc Decreased NPC1L1 expression in the liver from Chinese female gallstone patients
    Wei Cui
    Department of Surgery, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai Institute of Digestive Surgery, 200025, Shanghai, PR China
    Lipids Health Dis 9:17. 2010
    ..Many studies have found that cholesterol gallstones are more common in women than men...
  15. ncbi Common variants of ABCB4 and ABCB11 and plasma lipid levels: a study in sib pairs with gallstones, and controls
    Monica Acalovschi
    3rd Medical Clinic, University Iuliu Hatieganu, Cluj Napoca, Romania
    Lipids 44:521-6. 2009
    ..surveys have confirmed the association of low HDL-cholesterol and high triglyceride levels with cholesterol gallstones. Our objective was to analyze the relationship between plasma lipid levels and common polymorphisms of ABCB11 (..
  16. ncbi Hepatic cholesterol transporter ABCG8 polymorphisms in gallstone disease in an Indian population
    Siva Prasad Siddapuram
    Department of Basic Sciences, Asian Healthcare Foundation, Institute of Basic Sciences, Asian Institute of Gastroenterology, Hyderabad, Andhra Pradesh, India
    J Gastroenterol Hepatol 25:1093-8. 2010
    ..cholesterol transporter gene ATP-binding cassette, subfamily G, member 8 (ABCG8) in patients with cholesterol gallstones. The aim of this study was to analyze the relationship between D19H and T400K polymorphisms in the ABCG8 gene ..
  17. pmc ApoB-100, ApoE and CYP7A1 gene polymorphisms in Mexican patients with cholesterol gallstone disease
    Jaime Sánchez-Cuén
    División de Gastroenterología, Hospital Regional ISSSTE, Culiacan, Sinaloa 80230, Mexico
    World J Gastroenterol 16:4685-90. 2010
    ..To determine the possible association of the ApoB-100 (XbaI), ApoE (HhaI) and CYP7A1 (BsaI) gene polymorphisms, with the development of cholesterol gallstone disease (GD) in a Mexican population...
  18. ncbi Increased NPC1L1 and ACAT2 expression in the jejunal mucosa from Chinese gallstone patients
    Zhao Yan Jiang
    Department of Surgery, Shanghai Institute of Digestive Surgery, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China
    Biochem Biophys Res Commun 379:49-54. 2009
    The incidence of cholesterol gallstones is a very common disease. The aim of this study is to probe for underlying intestinal molecular defects associated with development of gallstones...
  19. ncbi Significant association of ABCG5 604Q and ABCG8 D19H polymorphisms with gallstone disease
    K K Kuo
    Division of Hepatobiliopancreatic Surgery, Department of Surgery, Kaohsiung Medical University Hospital, Taiwan
    Br J Surg 95:1005-11. 2008
    ..The formation of gallstones, supersaturated with cholesterol in bile, is determined by genetic and environmental factors...
  20. ncbi Detection of common bile duct stones: comparison between endoscopic ultrasonography, magnetic resonance cholangiography, and helical-computed-tomographic cholangiography
    Shintaro Kondo
    Department of Gastroenterology, Department of Radiology, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Japan
    Eur J Radiol 54:271-5. 2005
    ..We conducted this study to compare the diagnostic ability of EUS, MRCP, and HCT-C in patients with suspected choledocholithiasis...
  21. ncbi Sterol transporter adenosine triphosphate-binding cassette transporter G8, gallstones, and biliary cancer in 62,000 individuals from the general population
    Stefan Stender
    Department of Clinical Biochemistry, Rigshospitalet, Copenhagen, Denmark
    Hepatology 53:640-8. 2011
    ..that ABCG8 (adenosine triphosphate-binding cassette transporter G8) Asp19His (D19H) genotype predicted risk of gallstones and biliary cancer in the general population, we studied 62,279 white individuals from The Copenhagen City Heart ..
  22. pmc New pathophysiological concepts underlying pathogenesis of pigment gallstones
    Libor Vitek
    4th Department of Internal Medicine and Institute of Clinical Biochemistry and Laboratory Diagnostics, 1st Faculty of Medicine, Charles University of Prague, Prague, Czech Republic
    Clin Res Hepatol Gastroenterol 36:122-9. 2012
    Pigment gallstones, which are much less frequent than cholesterol stones, are classified descriptively as "black" or "brown"...
  23. ncbi High cholesterol absorption efficiency and rapid biliary secretion of chylomicron remnant cholesterol enhance cholelithogenesis in gallstone-susceptible mice
    David Q H Wang
    Department of Medicine, Harvard Medical School and Harvard Digestive Diseases Center, 330 Brookline Avenue, Boston, Massachusetts 02215, USA
    Biochim Biophys Acta 1733:90-9. 2005
    ..Differential metabolism of the chylomicron remnant cholesterol between C57L and AKR mice clearly plays a crucial role in the formation of lithogenic bile and gallstones.
  24. ncbi Large-scale identification of human biliary proteins from a cholesterol stone patient using a proteomic approach
    Hu Zhou
    Research Centre for Proteome Analysis, Key Lab of Proteomics, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, 200031, China
    Rapid Commun Mass Spectrom 19:3569-78. 2005
    ..Of the 218 proteins identified by 2D-LC/MS/MS, 92 were identified based on more than one unique tryptic peptide, and, of the total 222 proteins, 98 were identified based on more than one unique tryptic peptide...
  25. pmc Biliary lipids and cholesterol gallstone disease
    David Q H Wang
    Department of Medicine, Harvard Medical School, Liver Center and Gastroenterology Division, Beth Israel Deaconess Medical Center, and Harvard Digestive Diseases Center, and Brigham and Women s Hospital, Boston, MA 02115, USA
    J Lipid Res 50:S406-11. 2009
    ..summarizes current concepts of the physical-chemical state of biliary lipids in health and in lithogenic bile and outlines the molecular, genetic, hepatic, and cholecystic factors that underlie the pathogenesis of cholesterol gallstones.
  26. pmc Effect of ezetimibe on the prevention and dissolution of cholesterol gallstones
    Helen H Wang
    Department of Medicine, Liver Center and Gastroenterology Division, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Gastroenterology 134:2101-10. 2008
    ..contributes to gallstone formation, we explored whether the potent cholesterol absorption inhibitor ezetimibe could prevent gallstones and promote gallstone dissolution in mice and reduce biliary cholesterol content in human beings.
  27. ncbi Endoscopic papillary balloon dilation vs. sphincterotomy for removal of common bile duct stones: a prospective randomized pilot study
    J C Arnold
    Dept. of Medicine C, Ludwigshafen City Hospital, Ludwigshafen, Germany
    Endoscopy 33:563-7. 2001
    ..EST will therefore continue to be the standard procedure for stone removal in the near future. Further studies will be needed in order to compare the longer-term results with EST and EBD...
  28. pmc Gallstone disease is associated with increased mortality in the United States
    Constance E Ruhl
    Social and Scientific Systems, Inc, Silver Spring, Maryland 20910, USA
    Gastroenterology 140:508-16. 2011
    b>Gallstones are common and contribute to morbidity and health care costs, but their effects on mortality are unclear...
  29. pmc Statin use and the risk of cholecystectomy in women
    Chung Jyi Tsai
    Division of Digestive Diseases and Nutrition, University of Kentucky Medical Center, Lexington, Kentucky 40536 0298, USA
    Gastroenterology 136:1593-600. 2009
    ..Statins also prevent the formation of gallstones in animal studies, although the effect of statins on human gallstone disease has been controversial.
  30. ncbi Metabolic syndrome as a risk factor for gallstone disease
    Nahum Mendez-Sanchez
    Department of Biomedical Research, Medica Sur Clinic and Foundation, Puente de Piedra 150, Col Toriello Guerra, Mexico City, Mexico
    World J Gastroenterol 11:1653-7. 2005
    ..To establish an association between the presence of metabolic syndrome and the development of gallstone disease...
  31. ncbi Increased gallstone risk in humans conferred by common variant of hepatic ATP-binding cassette transporter for cholesterol
    Frank Grunhage
    Department of Internal Medicine I, University Hospital Bonn, Bonner Forum Biomedizin, Germany
    Hepatology 46:793-801. 2007
    ..In ASPs, gallstones were strongly linked to the D19H variant of the ABCG8 gene (NPL score = 7.1; P = 4.6 x 10(-13))...
  32. ncbi Molecular pathophysiology and physical chemistry of cholesterol gallstones
    Helen H Wang
    Department of Medicine, Liver Center and Gastroenterology Division, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Front Biosci 13:401-23. 2008
    Cholesterol gallstones are one of the most prevalent and most costly digestive diseases in the developed countries...
  33. ncbi Variation of the gene encoding the nuclear bile salt receptor FXR and gallstone susceptibility in mice and humans
    Peter Kovacs
    University of Leipzig, Department of Medicine III, Leipzig, Germany
    J Hepatol 48:116-24. 2008
    ..Here, we investigated further an association of the gene encoding FXR and gallstone susceptibility in mice and humans...
  34. ncbi Identification of cholelithogenic enterohepatic helicobacter species and their role in murine cholesterol gallstone formation
    Kirk J Maurer
    Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Gastroenterology 128:1023-33. 2005
    ..To test this, we prospectively investigated the effects of Helicobacter spp infection in cholesterol gallstone pathogenesis in the highly susceptible C57L/J mouse model...
  35. ncbi Increased expression of LXR alpha, ABCG5, ABCG8, and SR-BI in the liver from normolipidemic, nonobese Chinese gallstone patients
    Zhao Yan Jiang
    Department of Surgery, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai Institute of Digestive Surgery, 200025 Shanghai, China
    J Lipid Res 49:464-72. 2008
    ..In the present study of Chinese patients with gallstones, we investigated whether this phenomenon was correlated with the hepatic expression of genes participating in ..
  36. pmc Small sphincterotomy combined with papillary dilation with large balloon permits retrieval of large stones without mechanical lithotripsy
    Atsushi Minami
    Kawasaki Kyodo Hospital 2 1 5 Sakuramoto Kawasaki City 210 0833, Japan
    World J Gastroenterol 13:2179-82. 2007
    ..To introduce a new method: small endoscopic sphincterotomy (ES) combined with endoscopic papillary large balloon dilation (SES + EPLBD) to treat patients with large biliary stones...
  37. pmc Migrated endoclip and stone formation after cholecystectomy: a new danger of acute pancreatitis
    Kemal Dolay
    Bakirkoy Egitim ve Arastirma Hastanesi Genel Cerrahi Klinigi Endoskopi Unitesi Istanbul, Turkey
    World J Gastroenterol 13:6446-8. 2007
    ..The patient underwent early endoscopic retrograde cholangiopancreatography (ERCP) with endoscopic sphincterotomy and stone extraction...
  38. ncbi Timing of cholecystectomy after mild biliary pancreatitis: a systematic review
    Mark C van Baal
    Department of Operating Room Evidence Based Surgery, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Ann Surg 255:860-6. 2012
    ..To determine the risk of recurrent biliary events in the period after mild biliary pancreatitis but before interval cholecystectomy and to determine the safety of cholecystectomy during the index admission...
  39. ncbi Gallstone disease: Epidemiology, pathogenesis, and classification of biliary stones (common bile duct and intrahepatic)
    Susumu Tazuma
    Department of General Medicine and Clinical Pharmacotherapeutics, Hiroshima University Hospital and Graduate School of Biomedical Sciences, 1 2 3, Kasumi, Hiroshima 734 8551, Japan
    Best Pract Res Clin Gastroenterol 20:1075-83. 2006
    b>Gallstones are common in Western countries and Japan...
  40. pmc Disruption of gallbladder smooth muscle function is an early feature in the development of cholesterol gallstone disease
    B Lavoie
    Department of Anatomy and Neurobiology, University of Vermont School of Medicine, Burlington, VT 05405, USA
    Neurogastroenterol Motil 24:e313-24. 2012
    ..We studied a mouse model of gallstone disease to evaluate the development of GBSM dysfunction relative to changes in bile composition and the onset of sterile cholecystitis...
  41. ncbi Mice overexpressing hepatic Abcb11 rapidly develop cholesterol gallstones
    Anne Henkel
    Division of Hepatology, Department of Medicine, Northwestern University Feinberg School of Medicine, Tarry 14 711, 303 East Chicago Avenue, Chicago, Illinois, 60611, USA
    Mamm Genome 16:903-8. 2005
    ..This is likely because of increases in bile salt hydrophobicity but not because of alterations of other biliary lipid transporters. These findings strongly support Abcb11 as a Lith 1 gene...
  42. pmc Polymorphisms of estrogen receptors and risk of biliary tract cancers and gallstones: a population-based study in Shanghai, China
    Sue K Park
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institute of Health, EPS MSC 7234, 6120 Executive Boulevard, Bethesda, MD 20892 7234, USA
    Carcinogenesis 31:842-6. 2010
    ..1). No association was found for ESR1 haplotype based on four SNPs. These preliminary results suggest that variants in ESR genes could play a role in the etiology of biliary tract cancers, especially bile duct cancer in men...
  43. ncbi Self-reported history of hypercholesterolaemia and gallstones and the risk of prostate cancer
    F Bravi
    Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
    Ann Oncol 17:1014-7. 2006
    ..Although prostate cancer is one of the most common male cancers, its aetiology-and particularly the role of comorbidity-remains poorly understood...
  44. ncbi Helicobacter pylori and cholesterol gallstone formation in C57L/J mice: a prospective study
    Kirk J Maurer
    Division of Comparative Medicine, Massachusetts Institute of Technology, 77 Massachusetts Ave, Cambridge, MA 02139, USA
    Am J Physiol Gastrointest Liver Physiol 290:G175-82. 2006
    Recently, we demonstrated that cholesterol gallstone-prone C57L/J mice rarely develop gallstones unless they are infected with certain cholelithogenic enterohepatic Helicobacter species. Because the common gastric pathogen H...
  45. ncbi Epidemiology of gallstones
    Laura M Stinton
    Division of Gastroenterology, Department of Medicine, Faculty of Medicine, University of Calgary, Calgary, Alberta, Canada
    Gastroenterol Clin North Am 39:157-69, vii. 2010
    b>Gallstones are common with prevalences as high as 60% to 70% in American Indians and 10% to 15% in white adults of developed countries...
  46. ncbi Gallstones are associated with carotid atherosclerosis
    Nahum Mendez-Sanchez
    Liver Unit, Medica Sur Clinica and Foundation, Mexico City, Mexico
    Liver Int 28:402-6. 2008
    ..Carotid atherosclerosis is an excellent marker of risk for CD like stroke and myocardial infarction. The aim of this study was to assess the association between gallstones and carotid atherosclerosis.
  47. ncbi Association between cholecystectomy for gallstone disease and risk factors for cardiovascular disease
    Norberto C Chavez-Tapia
    Liver Research Unit, Medica Sur Clinic and Foundation, Mexico City
    Ann Hepatol 11:85-9. 2012
    ..The aim of this study is to analyse the relationship between cholecystectomy for gallstone disease and risk factors for cardiovascular disease...
  48. ncbi Genetic and functional identification of the likely causative variant for cholesterol gallstone disease at the ABCG5/8 lithogenic locus
    Oliver von Kampen
    Department of Internal Medicine I, Hospital Schleswig Holstein, Kiel, Germany
    Hepatology 57:2407-17. 2013
    ..Both the responsible variant and the molecular mechanism causing an increased incidence of gallstones in these patients have as yet not been identified...
  49. pmc Significant role of estrogen and progesterone receptor sequence variants in gallbladder cancer predisposition: a multi-analytical strategy
    Anshika Srivastava
    Department of Genetics, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India
    PLoS ONE 7:e40162. 2012
    ..Therefore the present study was designed to explore the role of genetic variants in estrogen (ESR1, ESR2) and progesterone (PGR) receptors in conferring risk of gallbladder cancer...
  50. ncbi EUS versus endoscopic retrograde cholangiography for patients with intermediate probability of bile duct stones: a prospective randomized trial
    Tarkan Karakan
    Department of Gastroenterology, Faculty of Medicine, Gazi University, Ankara, Turkey
    Gastrointest Endosc 69:244-52. 2009
    ..Factors affecting diagnostic accuracy and comparison of patients in the follow-up period for negative outcomes are not thoroughly investigated in a randomized trial...
  51. ncbi Endoscopic ultrasound versus endoscopic retrograde cholangiography for patients with intermediate probability of bile duct stones: a randomized trial comparing two management strategies
    M Polkowski
    Department of Gastroenterology, Medical Center for Postgraduate Education, Warsaw, Poland
    Endoscopy 39:296-303. 2007
    ..The assumption that such an approach is advantageous, however, has never been tested in a randomized trial...
  52. ncbi Strong association between gallstones and cardiovascular disease
    Nahum Mendez-Sanchez
    Department of Biomedical Research, Liver Unit Medica Sur Clinic and Foundation, Mexico City, Mexico
    Am J Gastroenterol 100:827-30. 2005
    ..We have investigated the association between GD and CHD in a cross-sectional study...
  53. ncbi Peritoneal gallstones following laparoscopic cholecystectomy: incidence, complications, and management
    J C Woodfield
    HBP Upper GI Unit, Department of General Surgery, Auckland City Hospital, Park Road, 92024, Private Bag, Auckland, New Zealand
    Surg Endosc 18:1200-7. 2004
    Gallstone spillage during laparoscopic cholecystectomy (LC) is a common intraoperative event. Although gallstones left in the peritoneal cavity were initially considered harmless, a significant number of complications have been reported...
  54. ncbi Cholesterol gallstones: a fellow traveler with metabolic syndrome?
    Scott M Grundy
    Am J Clin Nutr 80:1-2. 2004
  55. ncbi [Epidemiology and gallstones]
    Torben Jørgensen
    Forskningscenter for Forebyggelse og Sundhed, Amtssygehuset i Glostrup, Bygning 84 85, DK 2600 Glostrup
    Ugeskr Laeger 167:2610-3. 2005
    b>Gallstones are more frequent in women than in men due to pregnancy...
  56. ncbi Reduced susceptibility to cholesterol gallstone formation in mice that do not produce apolipoprotein B48 in the intestine
    Helen H Wang
    Department of Medicine, Liver Center and Gastroenterology Division, Beth Israel Deaconess Medical Center, Harvard Medical School and Harvard Digestive Diseases Center, Boston, MA 02215, USA
    Hepatology 42:894-904. 2005
    It has been found that polymorphisms in the apolipoprotein (APO)-B gene are associated with cholesterol gallstones in humans...
  57. pmc Effect of gallbladder hypomotility on cholesterol crystallization and growth in CCK-deficient mice
    Helen H Wang
    Department of Medicine, Liver Center and Gastroenterology Division, Beth Israel Deaconess Medical Center, Harvard Medical School and Harvard Digestive Diseases Center, Boston, MA, USA
    Biochim Biophys Acta 1801:138-46. 2010
    ..At day 15 on the lithogenic diet, 75% of knockout mice formed gallstones. However, wild-type mice formed very little mucin gel, liquid, and solid crystals, and gallstones were not ..
  58. ncbi Pathogenesis of cholesterol and pigment gallstones: an update
    Karel Johannes van Erpecum
    Dept of Gastroenterology and Hepatology, University Medical Center Utrecht, HP F 02 618, PO Box 85500, 3508 GA Utrecht, The Netherlands
    Clin Res Hepatol Gastroenterol 35:281-7. 2011
    ..UDP)-glucuronosyltransferase 1A1) responsible for bilirubin conjugation were recently associated with risk of gallstones as well as stone bilirubin content, suggesting common factors in cholesterol and pigment gallstone pathogenesis.
  59. pmc Gallstones and cholecystectomy in relation to risk of intra- and extrahepatic cholangiocarcinoma
    H Nordenstedt
    Upper Gastrointestinal Research, Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden
    Br J Cancer 106:1011-5. 2012
    ..The aetiology is largely unknown, and the potential roles of gallstones and gall bladder removal (cholecystectomy) need to be addressed in a large study with a long follow-up.
  60. ncbi Evidence for oxidative stress in the gall bladder mucosa of gall stone patients
    A Geetha
    Post Graduate Department of Biochemistry, Bharathi Women s College Autonomous, North Chennai, Tamil Nadu, India
    J Biochem Mol Biol Biophys 6:427-32. 2002
    ..The resultant increased risk of bile saturation would further contribute to the progress of gall stone formation...
  61. ncbi Gallstones associated with nonalcoholic steatohepatitis (NASH) and metabolic syndrome
    Oktay Yener
    Department of Surgery, Goztepe Training and Research Hospital, Istanbul
    Turk J Gastroenterol 21:411-5. 2010
    We aimed to evaluate the prevalence of non-alcoholic steatohepatitis and metabolic syndrome in patients with symptomatic gallstones undergoing laparoscopic or open cholecystectomy.
  62. ncbi Surgical treatment of gallstones
    Kurinchi S Gurusamy
    Department of Surgery, University College London Medical School, Royal Free Hospital, London, UK
    Gastroenterol Clin North Am 39:229-44, viii. 2010
    ..Cholecystectomy cannot be recommended for any group of patients having asymptomatic gallstones except in those undergoing major upper abdominal surgery for other pathologies (grade B)...
  63. ncbi Genetic analysis of cholesterol gallstone formation: searching for Lith (gallstone) genes
    David Q H Wang
    Liver Center, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, DA 601, Boston, MA 02215, USA
    Curr Gastroenterol Rep 6:140-50. 2004
    ..Because exceptionally close homology exists between mouse and human genomes, the orthologous human LITH genes can often be recognized after mouse genes are identified...
  64. ncbi The relationship between juxtapapillary duodenal diverticula and disorders of the biliopancreatic system: analysis of 350 patients
    T Zoepf
    Department of Gastroenterology, Academic Teaching Hospital, Ludwigshafen, Germany
    Gastrointest Endosc 54:56-61. 2001
    ..CONCLUSION: JPDD appears to be a risk factor for complications of endoscopic sphincterotomy and for gallbladder stones, bile duct stones, and their recurrence...
  65. ncbi Polymorphisms in ABCG5/G8 transporters linked to hypercholesterolemia and gallstone disease
    Iwona Rudkowska
    School of Dietetics and Human Nutrition, Faculty of Agricultural and Environmental Sciences, McGill University, Ste Anne de Bellevue, Quebec, Canada
    Nutr Rev 66:343-8. 2008
    ..plasma cholesterol to dietary and pharmaceutical interventions for hypercholesterolemia, and increased risk of gallstones. Clearly, the ABCG5 and ABCG8 genes play an important role in cholesterol homeostasis...
  66. ncbi Haplotype analysis of signal peptide (insertion/deletion) and XbaI polymorphisms of the APOB gene in gallbladder cancer
    Sachchida Nand Pandey
    Department of Genetics, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India
    Liver Int 27:1008-15. 2007
    ..We examined the effect of these polymorphisms individually as well as their haplotypes on GBC and gallstone patients in North Indian population...
  67. pmc Endoscopic papillary large balloon dilation alone without sphincterotomy for the treatment of large common bile duct stones
    Hoi Hung Chan
    Division of Gastroenterology, Department of Internal Medicine, Kaohsiung Veterans General Hospital, 386 Ta Chung 1st Road, Kaohsiung 81362, Taiwan
    BMC Gastroenterol 11:69. 2011
    ..Lethal pancreatitis has been reported after treatment for common bile duct stones using small endoscopic papillary balloon dilation...
  68. pmc New insights into the molecular mechanisms underlying effects of estrogen on cholesterol gallstone formation
    Helen H Wang
    Department of Medicine, Liver Center and Gastroenterology Division, Beth Israel Deaconess Medical Center, Harvard Medical School and Harvard Digestive Diseases Center, Boston, Massachusetts 02215, USA
    Biochim Biophys Acta 1791:1037-47. 2009
    ..and clinical studies have found that at all ages women are twice as likely as men to form cholesterol gallstones, and this gender difference begins since puberty and continues through the childbearing years, which highlight ..
  69. pmc Variants in hormone-related genes and the risk of biliary tract cancers and stones: a population-based study in China
    Sue K Park
    Department of Health and Human Services, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, 6120 Executive Boulevard, EPS 5024, MSC 7234, Bethesda, MD 20892 7234, USA
    Carcinogenesis 30:606-14. 2009
    ..Hormone-related factors, including parity, oral contraceptive use, obesity, and gallstones, have been implicated in the etiology of these cancers...
  70. ncbi Accuracy of linear endoscopic ultrasonography in the evaluation of patients with suspected common bile duct stones
    M Kohut
    Department of Gastroenterology, Silesian Medical Academy, Katowice, Poland
    Endoscopy 34:299-303. 2002
    ....
  71. ncbi Gallstone disease: from genes to evidence-based therapy
    Frank Lammert
    Department Internal Medicine II, Saarland University Hospital, Saarland University, Kirrberger Str, 66421 Hamburg Saar, Germany
    J Hepatol 48:S124-35. 2008
    ..Here, we summarize the molecular and genetic mechanisms of gallstone formation as well as the current evidence-based algorithms for diagnosis and therapy of gallbladder and bile duct stones...
  72. ncbi Medical history and the risk of biliary tract cancers in Shanghai, China: implications for a role of inflammation
    Gabriella Andreotti
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Blvd, EPS 8011, MSC 7240, Bethesda, MD 20892, USA
    Cancer Causes Control 22:1289-96. 2011
    ..2-15.0) or duodenal ulcers (OR = 3.7, 1.2-12.0) was associated with an excess risk of gallbladder cancer. Although the mechanisms are unclear, our results further support the role for inflammation in the etiology of biliary tract cancers...
  73. ncbi Hereditary liver disease: gallstones
    Henning Wittenburg
    University of Leipzig, Department of Internal Medicine, Neurology and Dermatology, Division of Gastroenterology and Rheumatology, Liebigstr 20, 04103 Leipzig, Germany
    Best Pract Res Clin Gastroenterol 24:747-56. 2010
    b>Gallstones are common in Western countries and due to pain and complications pose a substantial burden on health care systems. In general, cholesterol gallstones are distinguished from bilirubin gallstones...
  74. ncbi Association of periampullary diverticula with primary choledocholithiasis but not with secondary choledocholithiasis
    M H Kim
    Dept of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea
    Endoscopy 30:601-4. 1998
    ..The aims of our study are to evaluate the association between periampullary diverticula and gallstones according to their site and to clarify the origin of the common bile duct stones by analyzing their composition.
  75. ncbi Gallstones: environment, lifestyle and genes
    Caroline S Stokes
    Department of Medicine II, Saarland University Hospital, Homburg, Germany
    Dig Dis 29:191-201. 2011
    ..5 billion in the United States. The paradigm of environmental risk factors for gallstones has lately been challenged by genetic studies in experimental models and humans...
  76. ncbi Incidence and risk factors for gallstones in patients with inflammatory bowel disease: a large case-control study
    Fabrizio Parente
    Gastrointestinal Unit, A Manzoni Hospital, Lecco, and the Gastroenterology Unit, L Sacco University Hospital, Milan, Italy
    Hepatology 45:1267-74. 2007
    The risk for gallstones (GD) in inflammatory bowel diseases and the factors responsible for this complication have not been well established...
  77. ncbi Cholesterol gallstones and cancer of gallbladder (CAGB): molecular links
    Ajit Venniyoor
    Department of Medicine and Medical Oncology, INHS Asvini, Near RC Church, Colaba, Mumbai Bombay, Maharastra 400 005, India
    Med Hypotheses 70:646-53. 2008
    There is a known association between cholesterol gallstones and cancer of gall bladder (CAGB). However, the exact relation is not clear...
  78. ncbi [Gallstone biochemical characteristics using Fourier transform infrared spectroscopy method]
    P Sossé Djessou
    Laboratoire de Biochimie Medicale, UFR des sciences médicales, Abidjan, Cote d Ivoire
    Ann Biol Clin (Paris) 68:39-42. 2010
    This study reports biochemical composition and morphological aspect of gallstones as investigated by spectroscopy IR method...
  79. ncbi Endoscopic management of bile duct stones
    K F Binmoeller
    Department of Medicine and Surgery, University of California, San Diego 92103 8413, USA
    J Clin Gastroenterol 32:106-18. 2001
    ..Primary laparoscopic evaluation and management is reasonable in patients who have a low-to-moderate probability of having CBD stones...
  80. pmc Genetic variants involved in gallstone formation and capsaicin metabolism, and the risk of gallbladder cancer in Chilean women
    Sergio Baez
    Division of Social and Environmental Medicine, Department of Community Preventive Medicine, Niigata University Graduate School of Medical and Dental Sciences, 1 757 Asahimachi dori, Chuo Ku, Niigata 951 8510, Japan
    World J Gastroenterol 16:372-8. 2010
    ..To determine the effects of genetic variants associated with gallstone formation and capsaicin (a pungent component of chili pepper) metabolism on the risk of gallbladder cancer (GBC)...
  81. pmc Increased susceptibility to diet-induced gallstones in liver fatty acid binding protein knockout mice
    Yan Xie
    Department of Medicine, Division of Gastroenterology, Washington University School of Medicine, St Louis, MO 63110, USA
    J Lipid Res 50:977-87. 2009
    ..Seventy-five percent of L-Fabp(-/-) mice developed solid gallstones compared with 6% of wild-type mice with an increased gallstone score (3.29 versus 0.62, respectively; P < 0...
  82. ncbi Association of APOE-C1 gene cluster polymorphisms with gallstone disease
    M Dixit
    Department of Medical Genetics, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Raebareli Road, Lucknow 226014, India
    Dig Liver Dis 38:397-403. 2006
    ..Genetic polymorphisms in apolipoprotein genes may be associated with alteration in lipid profile and susceptibility to gallstone disease...
  83. pmc Gallstones and the risk of biliary tract cancer: a population-based study in China
    A W Hsing
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20852 7234, USA
    Br J Cancer 97:1577-82. 2007
    ..Among controls, a transabdominal ultrasound was performed to detect asymptomatic gallstones. Gallstones removed from cancer cases and gallstone patients were classified by size, weight, colour, pattern, ..
  84. ncbi Physical activity reduces the risk of symptomatic gallstones: a prospective cohort study
    Paul J R Banim
    Norfolk and Norwich University Hospital NHS Trust, University of East Anglia, Norwich, UK
    Eur J Gastroenterol Hepatol 22:983-8. 2010
    Physical activity may prevent gallstones formation by reducing bile stasis and plasma triglycerides and elevating high-density lipoprotein cholesterol levels...
  85. ncbi Statin use and risk of gallstone disease followed by cholecystectomy
    Michael Bodmer
    Division of Clinical Pharmacology and Toxicology, University Hospital, Basel, Switzerland
    JAMA 302:2001-7. 2009
    ..Statins decrease hepatic cholesterol biosynthesis and may therefore lower the risk of cholesterol gallstones by reducing the cholesterol concentration in the bile. Data on this association in humans are scarce.
  86. pmc Polymorphism of genes related to insulin sensitivity and the risk of biliary tract cancer and biliary stone: a population-based case-control study in Shanghai, China
    Shih Chen Chang
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, DHHS, Bethesda, MD 20892, USA
    Carcinogenesis 29:944-8. 2008
    ..Obesity and gallstones, both related to insulin resistance, are linked to an elevated risk of biliary cancer...
  87. ncbi Sequential endoscopic papillary balloon dilatation following limited sphincterotomy for common bile duct stones
    Rakesh Kochhar
    Department of Gastroenterology, Postgraduate Institute of Medical Education and Research, Chandigarh, 160012, India
    Dig Dis Sci 54:1578-81. 2009
    ..One patient had impaction of the dormia basket. We conclude that EPBD following EST is safe and effective in removing stones > or = 10 mm in size in over 90% of patients...
  88. ncbi Biliary lipids, water and cholesterol gallstones
    Karel J van Erpecum
    Department of Gastroenterology, University Hospital Utrecht, Utrecht, The Netherlands
    Biol Cell 97:815-22. 2005
    ..The remaining unstable cholesterol-enriched vesicles may nucleate crystals. Various aquaporins have recently been discovered throughout the biliary tract, with potential relevance for gallstone formation...
  89. ncbi Gallstones and Clonorchis sinensis infection: a hospital-based case-control study in Korea
    Dongil Choi
    Department of Radiology and Center for Imaging Science, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
    J Gastroenterol Hepatol 23:e399-404. 2008
    ..The authors conducted a hospital-based case-control study to evaluate the role of Clonorchis sinensis infection as a risk factor for the development of gallstones in Korea.
  90. ncbi Gallstones and gallbladder cancer-volume and weight of gallstones are associated with gallbladder cancer: a case-control study
    Ivan Roa
    Department of Pathology, Faculty of Medicine Universidad de la Frontera, Temuco, Chile
    J Surg Oncol 93:624-8. 2006
    b>Gallstones are considered the most important risk factor for gallbladder cancer.
  91. ncbi Risk factors for acute pancreatitis after endoscopic papillary balloon dilation
    Masanori Sugiyama
    First Department of Surgery, Kyorin University School of Medicine, 6 20 2 Shinkawa, Mitaka, Tokyo 181 8611, Japan
    Hepatogastroenterology 50:1796-8. 2003
    ..Although EPBD (endoscopic papillary balloon dilation) may cause acute pancreatitis, risk factors for post-EPBD pancreatitis have not been well described. We retrospectively analyzed risk factors predictive of acute pancreatitis after EPBD...
  92. pmc Can endoscopic papillary balloon dilation really preserve sphincter of Oddi function?
    I Yasuda
    First Department of Internal Medicine, Gifu University School of Medicine, Gifu, Japan
    Gut 49:686-91. 2001
    ..However, few studies have addressed this issue specifically. In this study, we investigated whether EPBD can preserve sphincter function, and evaluated whether or not such preservation has clinical significance...
  93. pmc Serum lipid levels and the risk of biliary tract cancers and biliary stones: A population-based study in China
    Gabriella Andreotti
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, DHHS, Bethesda, MD, USA
    Int J Cancer 122:2322-9. 2008
    ..b>Gallstones, the predominant risk factor for biliary cancers, are linked with hyperlipidemia...
  94. ncbi Pathogenesis of gallstones
    Niels Gerard Venneman
    Department of Gastroenterology and Hepatology, University Medical Center Utrecht, Utrecht, The Netherlands
    Gastroenterol Clin North Am 39:171-83, vii. 2010
    ..Hydrophobic bile salt pool, bile concentration, excess pronucleating mucin, and impaired gallbladder and intestinal motility are secondary phenomena in most cases but nevertheless may contribute to gallstone formation...
  95. ncbi Polymorphisms at cholesterol 7alpha-hydroxylase, apolipoproteins B and E and low density lipoprotein receptor genes in patients with gallbladder stone disease
    Zhao Yan Jiang
    Department of Surgery, Ruijin Hospital, Shanghai Second Medical University, Shanghai 200025, China
    World J Gastroenterol 10:1508-12. 2004
    ....
  96. ncbi Endoscopic balloon dilation of the biliary sphincter compared to endoscopic biliary sphincterotomy for removal of common bile duct stones during ERCP: a metaanalysis of randomized, controlled trials
    Todd H Baron
    Department of Medicine, Division of Gastroenterology and Hepatology, Mayo Medical Center, Rochester, Minnesota, USA
    Am J Gastroenterol 99:1455-60. 2004
    ..To compare the effect of endoscopic balloon dilation (EPBD) of the papilla with that of endoscopic biliary sphincterotomy (EST) in the treatment of patients with common bile duct stones...
  97. ncbi Risk factors for recurrence of primary bile duct stones after endoscopic biliary sphincterotomy
    D I Kim
    Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea
    Gastrointest Endosc 54:42-8. 2001
    ....
  98. ncbi Lost gallstones in laparoscopic cholecystectomy: all possible complications
    Jörg Zehetner
    Department of Surgery, Ludwig Boltzmann Institute for Operative Laparoscopy, AKH Linz, Krankenhausstrasse 9, 4020 Linz, Austria
    Am J Surg 193:73-8. 2007
    Laparoscopic cholecystectomy (LC) has been the gold standard for symptomatic gallstones for 15 years. During that time, several studies and case reports have been published which outline the possible complications of lost gallstones...
  99. ncbi Balloon sphincteroplasty for removing difficult bile duct stones
    A Maydeo
    Institute of Advanced Endoscopy, Mumbai, India
    Endoscopy 39:958-61. 2007
    ..The aim of this study was to evaluate the efficacy and safety of papillary balloon dilation after sphincterotomy for extraction of these difficult-to-remove bile duct stones...
  100. pmc Roles of infection, inflammation, and the immune system in cholesterol gallstone formation
    Kirk J Maurer
    Division of Gastroenterology, Brigham and Women s Hospital, Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA
    Gastroenterology 136:425-40. 2009
    ..Until recently, the role of the immune system in the pathogenesis of cholesterol gallstones was not considered a valid topic of research interest...
  101. pmc Diabetes in relation to biliary tract cancer and stones: a population-based study in Shanghai, China
    F M Shebl
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institute of Health, Bethesda, MD, USA
    Br J Cancer 103:115-9. 2010
    ..Biliary tract cancers are rare but fatal malignancies. Diabetes has been related to biliary stones, but its association with biliary tract cancers is less conclusive...

Research Grants63

  1. Promotion of PDT Induced phototoxicity by bile acids
    David Kessel; Fiscal Year: 2003
    ..These results are of potentially great clinical significance since UDCA is widely used for the treatment of gallstones and liver diseases, and its pharmacology and safety have been well established...
  2. Regulation of Metabolism by Dietary Sterols
    SHAILENDRA BHANUBHAI PATEL; Fiscal Year: 2013
    ..Some data from animal studies indicate improvement in atherosclerosis, but aggravation of stroke. These studies are important because they may help guide nutritional advice for a very large proportion of the patient population. ..
  3. Gallstone Pancreatitis: Pathogenesis and Treatment
    Isaac Samuel; Fiscal Year: 2012
    ..The commonest cause of acute pancreatitis world-wide is gallstones. This research proposal investigates how gallstone obstruction of the pancreatic duct may initiate acute ..
  4. Therapeutic Potential of PARP inhibitor for Acute Pancreatitis
    Latha Paka; Fiscal Year: 2010
    ..The most common causes of AP is the presence of gallstones and heavy alcohol (60%-80%) use that cause inflammation and necrosis of the pancreas...
  5. Role of Bile Acids and Gut Bacteria in GI Diseases
    Phillip B Hylemon; Fiscal Year: 2013
    ..give us the tools to carry out clinical studies to determine the most effective ways to decrease DCA in the bile acid pool with the aim of decreasing the risk of colon cancer and cholesterol gallstones, in some patients.
  6. ALIMENTARY TRACT LIPIDS IN HEALTH AND DISEASE
    MARTIN CONRAD CAREY; Fiscal Year: 2013
    ..techniques to advance fundamental understanding of bile and its two major dysfunctions, namely cholestasis and gallstones of both pigment and cholesterol types, i) The first aim will determine whether enterohepatic infection with ..
  7. Genetic influences in experimental pancreatitis
    Bishr Omary; Fiscal Year: 2013
    ..The majority of acute pancreatitis cases are related to alcohol or gallstones. Chronic pancreatitis, which results in progressive fibrosis and loss of parenchyma, is generally secondary to ..
  8. Hepatic Fatty Acid Metabolism and Steatosis
    NICHOLAS DAVIDSON; Fiscal Year: 2013
    ..We demonstrate that L-Fabp-/- mice are dramatically more susceptible to lithogenic diet (LD)-induced gallstones compared to C57BL/6 congenic controls with a phenotype including increased serum and hepatic free cholesterol, ..
  9. Control of lipid metabolism in insulin resistant states
    Sudha B Biddinger; Fiscal Year: 2013
    ..derangements in lipid homeostasis, leading to dyslipidemia, atherosclerosis, hepatic steatosis, and cholesterol gallstones. The factors that drive these derangements are unknown but must be determined in order to effectively treat the ..
  10. Development of an HTS assay to identify FXR antagonists
    Thomas P Burris; Fiscal Year: 2010
    ..FXR has been implicated as a drug target for the treatment of dyslipidemia (atheroscelerosis), diabetes, and gallstones. Although a few synthetic agonists have been identified for FXR, no selective antagonists have yet been ..
  11. REGULATION OF CHOLESTEROL METABOLISM
    Shunlin Ren; Fiscal Year: 2010
    ..Loss of cholesterol homeostasis causes diseases, such as atherosclerosis and cholesterol gallstones. Atherosclerosis and its clinical sequelae are a major cause of premature death and disability in the United ..
  12. Tissue specific mechanism of FXR in suppressing bile-acid synthesis
    Grace L Guo; Fiscal Year: 2011
    ..FXR dysfunction contributes to the development of cholestasis, gallstones, fatty-liver disease, and liver tumor...
  13. The role of cigarette smoke toxin and alcohol in pancreatitis
    Edwin C Thrower; Fiscal Year: 2013
    ..It is most often caused by gallstones and alcohol abuse...
  14. Protein-Crystal Molecular Recognition in Biomineralization
    Patrick S Stayton; Fiscal Year: 2012
    ..g. gingivitis) development. ..
  15. The role of T-cells and Th 1 immunity in cholesterol gallstones
    KIRK JAMES MAURER; Fiscal Year: 2011
    Cholesterol gallstones are a common costly disease with a complex incompletely understood pathogensesis [sic] involving genetic and environmental contributions...
  16. INTRACELLULAR TRANSPORT OF AMPHIPATHS
    Bruce Luxon; Fiscal Year: 2000
    ..crucial information needed to explain the pathogenesis of diseases as diverse as atherosclerosis, obesity, and gallstones. Insights and new methods developed in this proposal may apply to the intracellular transport of other ..
  17. PHYSICAL CHEMISTRY OF BILIRUBIN & ITS CONJUGATES
    WILLIAM SPIVAK; Fiscal Year: 1990
    ..derivatives of UCB (calcium bilirubinate or bilirubin polymers) make up part of the nidus of most cholesterol gallstones and are essential parts of the matrix of pigment gallstones, biliary sludge and the insoluble bile pigment ..
  18. The Interaction Between Hepatic Insulin Resistance and Cholesterol Metabolism
    Sudha B Biddinger; Fiscal Year: 2010
    ..Biddinger, focusing on the liver, will examine the molecular links between insulin resistance, dyslipidemia and gallstones, three features of the metabolic syndrome, and how they are modified by dietary factors...
  19. THE UNSUSPECTED SMALL STONE STUDY (USSS)
    James DiSario; Fiscal Year: 2000
    DESCRIPTION (adapted from the application) Gallstones are the most common and the most costly digestive disease, with an annual estimated expenditure of 5 billion dollars...
  20. THE METABOLISM OF STEROLS FROM SHELLFISH AND ALGAE
    WILLIAM CONNOR; Fiscal Year: 1980
    ..of cholesterol? Would they be hypocholesterolemic? Are these sterols or their derivatives found in bile, gallstones and atherosclerotic plaques? What is the origin of these different sterols, particularly in shellfish, ..
  21. ROLE OF THE GALLBLADDER IN PATHOGENESIS OF GALLSTONES
    LESTER WILLIAMS; Fiscal Year: 1991
    b>Gallstones (GS) are a significant health problem with cholecystectomy the most common abdominal operation in many hospitals...
  22. PRODUCTION OF URSODIOL FROM TURKEY BILE
    Tibor Sipos; Fiscal Year: 1991
    ..Ursodiol is medically used to dissolve gallstones. Ursodiol is very expensive ($800-$2000/kg) and only produced by companies outside the USA...
  23. Role of Nrf2 during cholestsis and gallstone formation
    ANGELA SLITT; Fiscal Year: 2009
    ..b>Gallstones can cause extrahepatic cholestasis by occluding the common bile duct...
  24. Biliary oxysterols and cholangiocarcinoma
    RAHUL P KUVER; Fiscal Year: 2010
    ..The presence and abundance of oxysterols in human bile and gallstones correlated with the presence of bacterial infection, and with the amount of bacterial DMA present in the stones...
  25. MYOGENIC DISORDERS OF THE GALLBLADDER
    Jose Behar; Fiscal Year: 2004
    ..These studies will be conducted in dissociated muscle cells from human GB's with gallstones with or without AC and from experimental AC induced by ligation of the common bile duct in animals with normal ..
  26. GALLSTONE FORMATION & PREVENTION DURING WEIGHT REDUCTION
    JAY MARKS; Fiscal Year: 1991
    We recently have found that obese patients rapidly losing weight develop cholesterol gallstones frequently (26% incidence) and rapidly (in less than 4 months)...
  27. ROLE OF CALCIUM AND CAFFEINE IN GALLSTONE DISEASE
    Keith Lillemoe; Fiscal Year: 1993
    ..dietary calcium and caffeine, two important components of the American diet, in pathogenesis and prevention of gallstones. Our hypothesis for this proposal are that oral calcium supplementation promotes gallstone formation and that ..
  28. Host-Microbial Control of Deoxycholate Producton
    Paul Dawson; Fiscal Year: 2005
    ..deoxycholate production is a positive risk factor for the development of colon cancer as well as cholesterol gallstones. However, the factors that regulate deoxycholate production are poorly understood...
  29. NOVEL ERYTHROMYCIN ANALOGS FOR GI MOTILITY DISORDERS
    Christopher Carreras; Fiscal Year: 2000
    ..disorders such as gastroesophogeal reflux disease (GERD), gastroparesis, postoperative ileus, scleroderma, gallstones, and as a quick and effective drug to stimulate stomach emptying in patients requiring emergency surgery...
  30. MECHANISM OF ESTROGEN EFFECTS ON BILIARY CHOLESTEROL
    FRED KERN; Fiscal Year: 1991
    Cholesterol gallstones, a common and costly disease, occurs 2.5 times as frequently in women as in men, and its incidence is doubled again by contraceptive steroids (CS) or postmenopausal estrogen...
  31. Role of Gallbladder Ion Transport in Gallstone Formation
    A Moser; Fiscal Year: 2006
    ..biology and instilled a strong desire to become a clinician scientist and an innovator in the treatment of gallstones. To develop his research career, the candidate needs significantly more time for scientific pursuits as well as ..
  32. HYPERBILIRUBINEMIA TREATMENT WITH CLONED THERMO-ENZYMES
    Larry Allen; Fiscal Year: 1993
    ..An additional potential use is the development of minimally invasive treatment for pigmented gallstones. In Phase I, the feasibility of the project was successfully shown by identifying six thermophilic organisms ..
  33. Role of ABCG5 and ABCG8 in Sterol Metabolism
    Helen Hobbs; Fiscal Year: 2007
    ..human diseases: coronary atherosclerosis, the leading cause of death in the Western societies, and cholesterol gallstones, one of the leading indicators for surgery in the United States...
  34. Abcb11 and Hepatic Transport
    Anne Henkel; Fiscal Year: 2009
    ..Cholelithiasis is a major health problem affecting over 20 million Americans annually. A family history of gallstones has been identified as a strong risk factor for the development of gallstones, suggesting a genetic basis to ..
  35. OBESITY, LEPTIN AND GALLSTONE PATHOGENESIS
    Henry Pitt; Fiscal Year: 2005
    DESCRIPTION (Verbatim from Applicant's Abstract): Approximately 30,000,000 Americans have gallstones, and the vast majority are overweight...
  36. Gender Differences in Gallstone Pathogenesis
    MOHAMMAD ABEDIN; Fiscal Year: 2006
    ..Female sex hormones have been implicated as contributory factors to the promotion of gallstones. Female sex hormones promote gallstone formation by increasing biliary cholesterol saturation and gallbladder ..
  37. MUCIN AND TREFOIL PROTEINS IN GALLSTONE PATHOGENESIS
    David Nunes; Fiscal Year: 1999
    ..formation, mucin accelerates cholesterol nucleation and crystal growth and forms the scaffold on which mature gallstones are built...
  38. MUCIN AND NON-MUCIN PROTEINS IN GALLSTONE PATHOGENESIS
    Gwynneth Offner; Fiscal Year: 2000
    ..The overall goal of this project is to understand the role of gallbladder mucin in the pathogenesis of cholesterol gallstones. Medical or surgical treatment for symptomatic gallstones is a frequent cause for hospitalization in the United ..
  39. DIET & LIPOPROTEIN INDUCED EFFECTS ON BILE SECRETION
    Martin Scobey; Fiscal Year: 1990
    ..The dietary perturbations employed will take advantage of the greater occurence of cholesterol gallstones seen in this species when animals are fed diets with increasing amounts of cholesterol and polyunsaturated fat...
  40. Jaundice Chip: Diagnostic tool for cholestatic liver dis
    Jorge Bezerra; Fiscal Year: 2006
    ..same genes also cause debilitating liver diseases or increase susceptibility to common biliary diseases, such as gallstones. Despite the remarkable progress in understanding how these genes cause liver disease in humans, the new ..
  41. The Role of Nitric Oxide in Cholesterol Homeostasis
    Melanie Ihrig; Fiscal Year: 2003
    ..Prolonged intestinal transit time augments formation of cholesterol gallstones, and if prolonged intestinal transit time is the underlying cause of hypercholesterolemia in iNOS-deficient mice,..
  42. PROTEIN LIPID INTERACTIONS IN GALLSTONE PATHOGENESIS
    Nezam Afdhal; Fiscal Year: 2002
    ..formation and this proposal will examine the mechanism by which mucin interacts with biliary lipids to promote gallstones. The specific Aims are to 1) Characterize the interaction of specific sites of the mucin molecule with lipid ..
  43. SECOND MESSENGERS, GALLBLADDER ABSORPTION AND GALLSTONES
    MOHAMMAD ABEDIN; Fiscal Year: 2001
    DESCRIPTION: (Adapted from investigator's abstract) The development of cholesterol gallstones involves alterations in the relationship of the amount of cholesterol, phospholipid and bile salts present in bile resulting in bile becoming ..
  44. Consomic Strains Between C57BL/6 and PWD
    Leah Rae Donahue; Fiscal Year: 2006
    ..growth and fertility, sleep disorders, lung function, kidney function, obesity, diabetes, atherosclerosis, gallstones, hematology, osteoporosis, neurological function, immunologic function, hearing, sight, learning, memory, and ..
  45. DIETARY INFLUENCE ON GALLSTONES
    KENNETH HAYES; Fiscal Year: 1993
    Cholesterol gallstones are a serious and expensive complication of the Western diet, commonly occurring in overweight women consuming too many calories and expressing a high plasma lipid, hyperinsulinemic profile...
  46. Cholesterol Nanodomain Formation in Lipid Membranes
    STEVEN WRENN; Fiscal Year: 2009
    ..Cholesterol crystals are precursors to gallstones;inhibiting cholesterol nucleation offers a potential means of preventing stones...
  47. GENETIC DETERMINANTS OF CHOLESTEROL GALLSTONES IN MICE
    Beverly Paigen; Fiscal Year: 2005
    ..Identifying the full range of QTLs that lead to gallstone disease in the mouse will position the field of cholesterol gallstone research to take advantage of the large genomic sequencing efforts currently underway. ..
  48. Epidemiology of hepatocellular carcinoma
    Cynthia Ko; Fiscal Year: 2006
    ....
  49. A Primary-Care Based Colorectal Cancer Screening Program
    Cynthia Ko; Fiscal Year: 2006
    ..If successful, this program may be useful to other large primary care practices, and may also help to improve utilization of other types of cancer prevention services ..
  50. The effect of physical activity on metabolic syndrome in pregnancy and fetal outc
    Cynthia Ko; Fiscal Year: 2008
    ..It may offer a safe and readily available method to control weight and improve infant health during and after pregnancy. [unreadable] [unreadable] [unreadable]..
  51. Colonoscopy quality and outcomes in clinical practice
    Cynthia W Ko; Fiscal Year: 2010
    ..The various algorithms we develop will be tested in a second, validation subset of our database to find the algorithm with optimal performance characteristics. ..
  52. Role of CCK Receptor in Acute Pancreatitis Pathogenesis
    Isaac Samuel; Fiscal Year: 2007
    ..James W. Maher, MD, Director, Division of Gastrointestinal Surgery, University of Iowa College of Medicine, Iowa City. [] PHS 398/2590 (Rev. 05/01) Page__ 26 Continuation Format Page [] ..