alopecia

Summary

Summary: Absence of hair from areas where it is normally present.

Top Publications

  1. ncbi Male androgenetic alopecia
    Deepani Rathnayake
    Department of Dermatology, St Vincent s Hospital Melbourne, Fitzroy, Melbourne, Victoria 3065, Australia
    Expert Opin Pharmacother 11:1295-304. 2010
  2. pmc Targeted ablation of the vitamin D receptor: an animal model of vitamin D-dependent rickets type II with alopecia
    Y C Li
    Endocrine Unit, Massachusetts General Hospital and Harvard Medical School, 15 Fruit Street, Boston, MA 02114, USA
    Proc Natl Acad Sci U S A 94:9831-5. 1997
  3. ncbi The diagnosis and treatment of iron deficiency and its potential relationship to hair loss
    Leonid Benjamin Trost
    Department of Dermatology, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    J Am Acad Dermatol 54:824-44. 2006
  4. pmc Bald scalp in men with androgenetic alopecia retains hair follicle stem cells but lacks CD200-rich and CD34-positive hair follicle progenitor cells
    Luis A Garza
    Department of Dermatology, Kligman Laboratories, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Clin Invest 121:613-22. 2011
  5. ncbi Susceptibility variants for male-pattern baldness on chromosome 20p11
    Axel M Hillmer
    Department of Genomics, Life and Brain Center, University of Bonn, D 53127 Bonn, Germany
    Nat Genet 40:1279-81. 2008
  6. ncbi Is androgenetic alopecia a photoaggravated dermatosis?
    Ralph M Trueb
    Department of Dermatology, University Hospital of Zurich, Zurich, Switzerland
    Dermatology 207:343-8. 2003
  7. ncbi Prevalence of androgenetic alopecia in China: a community-based study in six cities
    T L Wang
    Department of Dermatology, Peking University People s Hospital, Beijing 100044, China
    Br J Dermatol 162:843-7. 2010
  8. ncbi Chemotherapy-induced alopecia and effects on quality of life among women with breast cancer: a literature review
    Julie Lemieux
    Unité de recherche en santé des populations, Centre Hospitalier Affilie Universitaire De Quebec, Quebec, Que, Canada
    Psychooncology 17:317-28. 2008
  9. pmc Genome-wide scan and fine-mapping linkage study of androgenetic alopecia reveals a locus on chromosome 3q26
    Axel M Hillmer
    Department of Genomics, Life and Brain Center, University of Bonn, D 53127 Bonn, Germany
    Am J Hum Genet 82:737-43. 2008
  10. ncbi Hair density, hair diameter and the prevalence of female pattern hair loss
    M P Birch
    Department of Dermatology, Royal Hallamshire Hospital, Sheffield S10 2JF, UK
    Br J Dermatol 144:297-304. 2001

Detail Information

Publications311 found, 100 shown here

  1. ncbi Male androgenetic alopecia
    Deepani Rathnayake
    Department of Dermatology, St Vincent s Hospital Melbourne, Fitzroy, Melbourne, Victoria 3065, Australia
    Expert Opin Pharmacother 11:1295-304. 2010
    Androgenetic alopecia affects up to 80% of males by the age of 80. The synonym 'male-pattern hair loss' highlights the fact that hair loss occurs in a defined and reproducible pattern...
  2. pmc Targeted ablation of the vitamin D receptor: an animal model of vitamin D-dependent rickets type II with alopecia
    Y C Li
    Endocrine Unit, Massachusetts General Hospital and Harvard Medical School, 15 Fruit Street, Boston, MA 02114, USA
    Proc Natl Acad Sci U S A 94:9831-5. 1997
    ..b>Alopecia, which is not a feature of vitamin D deficiency, is seen in some kindreds...
  3. ncbi The diagnosis and treatment of iron deficiency and its potential relationship to hair loss
    Leonid Benjamin Trost
    Department of Dermatology, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    J Am Acad Dermatol 54:824-44. 2006
    ..Some suggest that iron deficiency may be related to alopecia areata, androgenetic alopecia, telogen effluvium, and diffuse hair loss, while others do not...
  4. pmc Bald scalp in men with androgenetic alopecia retains hair follicle stem cells but lacks CD200-rich and CD34-positive hair follicle progenitor cells
    Luis A Garza
    Department of Dermatology, Kligman Laboratories, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Clin Invest 121:613-22. 2011
    Androgenetic alopecia (AGA), also known as common baldness, is characterized by a marked decrease in hair follicle size, which could be related to the loss of hair follicle stem or progenitor cells...
  5. ncbi Susceptibility variants for male-pattern baldness on chromosome 20p11
    Axel M Hillmer
    Department of Genomics, Life and Brain Center, University of Bonn, D 53127 Bonn, Germany
    Nat Genet 40:1279-81. 2008
    We carried out a genome-wide association study in 296 individuals with male-pattern baldness (androgenetic alopecia) and 347 controls...
  6. ncbi Is androgenetic alopecia a photoaggravated dermatosis?
    Ralph M Trueb
    Department of Dermatology, University Hospital of Zurich, Zurich, Switzerland
    Dermatology 207:343-8. 2003
    Progressive thinning of the scalp hair in androgenetic alopecia (AGA) results in a gradual decline in natural protection of the scalp from ultraviolet radiation (UVR)...
  7. ncbi Prevalence of androgenetic alopecia in China: a community-based study in six cities
    T L Wang
    Department of Dermatology, Peking University People s Hospital, Beijing 100044, China
    Br J Dermatol 162:843-7. 2010
    There are racial differences in the prevalence and types of androgenetic alopecia (AGA). The prevalence of AGA has been studied in Caucasians and in some Asian people...
  8. ncbi Chemotherapy-induced alopecia and effects on quality of life among women with breast cancer: a literature review
    Julie Lemieux
    Unité de recherche en santé des populations, Centre Hospitalier Affilie Universitaire De Quebec, Quebec, Que, Canada
    Psychooncology 17:317-28. 2008
    b>Alopecia is a common side effect of chemotherapies used in the treatment of breast cancer. The aim of this review is to describe the effects of alopecia on quality of life (QOL) in this population.
  9. pmc Genome-wide scan and fine-mapping linkage study of androgenetic alopecia reveals a locus on chromosome 3q26
    Axel M Hillmer
    Department of Genomics, Life and Brain Center, University of Bonn, D 53127 Bonn, Germany
    Am J Hum Genet 82:737-43. 2008
    Androgenetic alopecia (AGA, male pattern baldness) is the most common form of hair loss. The origin of AGA is genetic, with the X chromosome located androgen receptor gene (AR) being the only risk gene identified to date...
  10. ncbi Hair density, hair diameter and the prevalence of female pattern hair loss
    M P Birch
    Department of Dermatology, Royal Hallamshire Hospital, Sheffield S10 2JF, UK
    Br J Dermatol 144:297-304. 2001
    ..The hair diameter data suggest that low hair density is not due to progressive diminution in hair follicle size and that follicular miniaturization may occur within the space of a single hair cycle...
  11. pmc Mice with alopecia, osteoporosis, and systemic amyloidosis due to mutation in Zdhhc13, a gene coding for palmitoyl acyltransferase
    Amir N Saleem
    Institute of Biomedical Sciences, Academia Sinica, Nankang, Taiwan
    PLoS Genet 6:e1000985. 2010
    ..screen, we identified mice with failure to thrive, shortened life span, skin and hair abnormalities including alopecia, severe osteoporosis, and systemic amyloidosis (both AA and AL amyloids depositions)...
  12. ncbi Weathering of the hairless scalp: a study using skin capacitance imaging and ultraviolet light-enhanced visualization
    E Xhauflaire-Uhoda
    Department of Dermatopathology, University Hospital Sart Tilman, Liege, Belgium
    Clin Exp Dermatol 35:83-5. 2010
    ..The induced changes are better revealed under ultraviolet light examination. Any alteration in the epidermal maturation is potentially reflected by stratum corneum changes observed as disturbances on skin-capacitance imaging...
  13. ncbi Association of androgenetic alopecia and hypertension
    Serge Ahouansou
    Department of Public Health, Avicenne Hospital, Assistance Publique Hopitaux de Paris, Bobigny Cedex France
    Eur J Dermatol 17:220-2. 2007
    Androgenetic alopecia is considered to be associated with coronary heart disease but the explanation of this association remains unknown. Hypertension is highly prevalent in patients with coronary heart disease...
  14. pmc Male-pattern baldness susceptibility locus at 20p11
    J Brent Richards
    Department of Twin Research and Genetic Epidemiology, King s College London, London SE1 7EH, UK
    Nat Genet 40:1282-4. 2008
    We conducted a genome-wide association study for androgenic alopecia in 1,125 men and identified a newly associated locus at chromosome 20p11.22, confirmed in three independent cohorts (n = 1,650; OR = 1.60, P = 1...
  15. pmc Keratin 17 null mice exhibit age- and strain-dependent alopecia
    Kevin M McGowan
    Department of Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Genes Dev 16:1412-22. 2002
    ..We report that K17 null mice develop severe alopecia during the first week postbirth, correlating with hair fragility, alterations in follicular histology, and ..
  16. ncbi Scalp dermoscopy of androgenetic alopecia in Asian people
    Shigeki Inui
    Department of Regenerative Dermatology, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan
    J Dermatol 36:82-5. 2009
    ..is used mainly for diagnosing pigmented skin lesions, this device has been reported to be useful in observing alopecia areata and frontal fibrosing alopecia...
  17. ncbi Exposing the human nude phenotype
    J Frank
    Nature 398:473-4. 1999
  18. ncbi Decreased serum ferritin is associated with alopecia in women
    Jonathan Kantor
    Department of Dermatology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    J Invest Dermatol 121:985-8. 2003
    b>Alopecia in women is a common problem, and conflicting observational data have failed to determine whether an association exists between alopecia and iron deficiency in women...
  19. ncbi Androgenetic alopecia in men aged 40-69 years: prevalence and risk factors
    G Severi
    Division of Epidemiology and Biostatistics, European Institute of Oncology, Milan, Italy
    Br J Dermatol 149:1207-13. 2003
    The epidemiology of androgenetic alopecia (AGA) is not fully understood. Although a strong genetic basis has long been identified, little is known of its non-genetic causes.
  20. pmc Hair follicle stem cell-specific PPARgamma deletion causes scarring alopecia
    Pratima Karnik
    Department of Dermatology, University Hospitals Case Medical Center, Case Western Reserve University, Cleveland, Ohio 44106, USA
    J Invest Dermatol 129:1243-57. 2009
    ..deletion of PPARgamma in follicular stem cells in mice causes a skin and hair phenotype that emulates scarring alopecia. These studies suggest that PPARgamma is crucial for healthy pilosebaceous units and it is the loss of this ..
  21. ncbi Role of hormones in pilosebaceous unit development
    D Deplewski
    Department of Medicine and Pediatrics, The University of Chicago Pritzker School of Medicine, Illinois 60637 1470, USA
    Endocr Rev 21:363-92. 2000
    ..basis of PSU development and the hormonal treatment of the PSU disorders hirsutism, acne vulgaris, and pattern alopecia are reviewed...
  22. ncbi TrichoScan: combining epiluminescence microscopy with digital image analysis for the measurement of hair growth in vivo
    R Hoffmann
    Department of Dermatology, Philipp University, Deutschhausstrasse 9, 35033 Marburg, Germany
    Eur J Dermatol 11:362-8. 2001
    ....
  23. ncbi Incidence of female androgenetic alopecia (female pattern alopecia)
    O T Norwood
    Norwood and Lehr: Hair Transplant Clinic, Oklahoma City, Oklahoma 73112, USA
    Dermatol Surg 27:53-4. 2001
    BACKGROUND: Female pattern alopecia seems to be increasing. A recent article suggests that female androgenetic alopecia may not be androgen dependent and is a different entity than male androgenetic alopecia...
  24. ncbi Towards a molecular understanding of hair loss and its treatment
    G Cotsarelis
    Department of Dermatology and Cell and Developmental Biology, University of Pennsylvania School of Medicine, M8 Stellar Chance Laboratories, 422 Curie Blvd, Philadelphia, PA 19104, USA
    Trends Mol Med 7:293-301. 2001
    Most common forms of hair loss (alopecia) are caused by aberrant hair follicle cycling and changes in hair follicle morphology. However, current treatments for alopecia do not specifically target these processes...
  25. ncbi The prevalence and types of androgenetic alopecia in Korean men and women
    J H Paik
    Department of Dermatology, College of Medicine, Kyung Hee University, 1 Hoeki-dong, Dongdaemun-ku, Seoul 130-702, Korea
    Br J Dermatol 145:95-9. 2001
    BACKGROUND: There are racial differences in the prevalence and types of androgenetic alopecia (AGA)...
  26. ncbi Induction of cellular immunity against hair follicle melanocyte causes alopecia
    Hiroshi Nagai
    Department of Dermatology, Department of Clinical Molecular Medicine, Kobe University Graduate School of Medicine, 7 5 1 Kusunoki cho, Chuo Ku, Kobe 650 0017, Japan
    Arch Dermatol Res 298:131-4. 2006
    b>Alopecia areata (AA) is generally regarded as an organ-specific autoimmune disease...
  27. ncbi Association of androgenetic alopecia with smoking and its prevalence among Asian men: a community-based survey
    Lin Hui Su
    Department of Dermatology, Far Eastern Memorial Hospital, Taipei, Taiwan
    Arch Dermatol 143:1401-6. 2007
    To evaluate the association of androgenetic alopecia (AGA) with smoking and to estimate its prevalence among Asian men.
  28. pmc Conditional epidermal expression of TGFbeta 1 blocks neonatal lethality but causes a reversible hyperplasia and alopecia
    X Liu
    Laboratory of Cellular Carcinogenesis and Tumor Promotion, National Cancer Institute, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 98:9139-44. 2001
    ..However, chronic expression of TGFbeta1 in adult DTs caused severe alopecia characterized by epidermal and follicular hyperproliferation, apoptosis, as well as dermal fibrosis and ..
  29. ncbi Androgenetic alopecia and insulin resistance in young men
    José Gerardo González-González
    Servicio de Endocrinologia, Dr Jose Eleuterio Gonzalez University Hospital, Facultad de Medicina, Universidad Autonoma de Nuevo Leon, Ave Madero y Gonzalitos S N, Monterrey, Mexico
    Clin Endocrinol (Oxf) 71:494-9. 2009
    Epidemiological studies have associated androgenetic alopecia (AGA) with severe young-age coronary artery disease and hypertension, and linked it to insulin resistance...
  30. ncbi Molecular mechanisms of androgenetic alopecia
    Ralph M Trueb
    Department of Dermatology, University Hospital of Zurich, Gloriastr 31, 8091 Zurich, Switzerland
    Exp Gerontol 37:981-90. 2002
    Androgenetic alopecia (AGA) is hereditary and androgen-dependent, progressive thinning of the scalp hair that follows a defined pattern...
  31. ncbi Radiation-induced temporary alopecia after embolization of cerebral arteriovenous malformations
    Chung Shi Wen
    Department of Surgery, National Taiwan University Hospital and National Taiwan University College of Medicine, 7 Chung Shan S Rd, 10016, Taipei, Taiwan, ROC
    Clin Neurol Neurosurg 105:215-7. 2003
    b>Alopecia after endovascular embolization of cerebral arteriovenous malformations (AVMs) is uncommon. In this report, we present a 33-year-old man who developed temporary alopecia after staged embolization of a cerebral AVM...
  32. pmc Alopecia, neurological defects, and endocrinopathy syndrome caused by decreased expression of RBM28, a nucleolar protein associated with ribosome biogenesis
    Janna Nousbeck
    Laboratory of Molecular Dermatology, Department of Dermatology, Rambam Health Care Campus, 31096 Haifa, Israel
    Am J Hum Genet 82:1114-21. 2008
    ..We investigated an autosomal-recessive phenotype characterized by alopecia, progressive neurological defects, and endocrinopathy (ANE syndrome)...
  33. ncbi Androgenetic alopecia in adolescents: a report of 43 cases
    Beom Joon Kim
    Department of Dermatology, Seoul National University College of Medicine, 28 Yongon Dong, Jongno gu, Seoul 110 744, Korea
    J Dermatol 33:696-9. 2006
    Androgenetic alopecia (AGA) is the most common type of hair loss in adults, but it also occurs in adolescents, though its prevalence among this younger population is not well established...
  34. ncbi Men with Kennedy disease have a reduced risk of androgenetic alopecia
    R Sinclair
    Department of Dermatology, University of Melbourne, St Vincent s Hospital, Fitzroy 3065, Victoria, Australia
    Br J Dermatol 157:290-4. 2007
    ..Degree of expansion of this repeat region, located in the first exon, is correlated with age at onset and disease severity. Androgenetic alopecia (AGA) is a polygenic trait also associated with functional polymorphism of the AR gene.
  35. ncbi The effects of minoxidil, 1% pyrithione zinc and a combination of both on hair density: a randomized controlled trial
    R S Berger
    Hill Top Research, Inc, East Brunswick, NJ, USA
    Br J Dermatol 149:354-62. 2003
    ..Recent studies of antidandruff shampoos or tonics containing antifungal or antibacterial agents produced effects suggestive of a potential hair growth benefit...
  36. doi No association between serum ferritin levels >10 microg/l and hair loss activity in women
    Amadé Bregy
    Dermatology 217:1-6. 2008
  37. pmc Multi-layered environmental regulation on the homeostasis of stem cells: the saga of hair growth and alopecia
    Chih Chiang Chen
    Institute of Clinical Medicine and Department of Dermatology, National Yang Ming University and Department of Dermatology, Taipei Veterans General Hospital, Taipei, Taiwan
    J Dermatol Sci 66:3-11. 2012
    ..Therapies do not necessarily have to be achieved by using stem cells themselves which may constitute a higher risk but by modulating stem cell activity through targeting one or multiple layers of their micro- and macro-environments...
  38. pmc Six novel susceptibility Loci for early-onset androgenetic alopecia and their unexpected association with common diseases
    Rui Li
    Departments of Medicine, Human Genetics, Epidemiology, and Biostatistics, Lady Davis Institute, Jewish General Hospital, McGill University, Montreal, Quebec, Canada
    PLoS Genet 8:e1002746. 2012
    Androgenetic alopecia (AGA) is a highly heritable condition and the most common form of hair loss in humans...
  39. ncbi Androgenic alopecia is not useful as an indicator of men at high risk of prostate cancer
    Ruben G Cremers
    Department of Epidemiology, Biostatistics and HTA, Radboud University Nijmegen Medical Centre, The Netherlands
    Eur J Cancer 46:3294-9. 2010
    Androgens are assumed to play a central role in the pathophysiology of both prostate cancer (PC) and androgenic alopecia (AA). A correlation between the two phenotypes may be relevant for identification of men at high risk of PC...
  40. ncbi Ancestral founder mutation of the nude (FOXN1) gene in congenital severe combined immunodeficiency associated with alopecia in southern Italy population
    M Adriani
    Department of Pediatrics, Federico II University, Naples, Italy
    Ann Hum Genet 68:265-8. 2004
    ..In this community, four additional children affected with congenital alopecia died in early childhood because of severe infections...
  41. ncbi Evidence for two independent functional variants for androgenetic alopecia around the androgen receptor gene
    Joanna E Cobb
    Department of Physiology, University of Melbourne, Melbourne, Victoria, Australia
    Exp Dermatol 19:1026-8. 2010
    The gene encoding the androgen receptor (AR) is associated with male pattern baldness (androgenetic alopecia - AGA). In case-control and family analyses, we mapped AR and the adjacent intergenic regions...
  42. ncbi Role of genetics and sex steroid hormones in male androgenetic alopecia and female pattern hair loss: an update of what we now know
    Leona Yip
    Department of Dermatology, St Vincent s Hospital, Melbourne, Victoria, Australia
    Australas J Dermatol 52:81-8. 2011
    ..and the influence of sex steroid hormones are indisputable to the pathogenesis of male androgenetic alopecia (MAGA). The role of sex steroid hormones in female pattern hair loss (FPHL) is less known...
  43. pmc Male pattern baldness and prostate cancer risk in a population-based case-control study
    Jonathan L Wright
    Department of Urology, University of Washington School of Medicine, Seattle, WA, United States
    Cancer Epidemiol 34:131-5. 2010
    ..Studies exploring the relationship between the two conditions have been inconclusive. Using a population-based, case-control study of PCa, we explore the relationship between early-onset MPB and PCa risk...
  44. ncbi Cardiomyopathy with alopecia and palmoplantar keratoderma (CAPK) is caused by a JUP mutation
    H Erken
    Departments of Cardiology Pathology, Ankara University School of Medicine, Sihhiye, Ankara 06100, Turkey
    Br J Dermatol 165:917-21. 2011
    ..autosomal recessive syndrome in a family with arrhythmogenic right ventricular cardiomyopathy associated with alopecia and PPK (named CAPK). Genetic investigation of the family led us to find a homozygous disease-causing mutation, p...
  45. ncbi Susceptibility variants on chromosome 7p21.1 suggest HDAC9 as a new candidate gene for male-pattern baldness
    F F Brockschmidt
    Department of Genomics, Life and Brain Center, University of Bonn, Sigmund Freud Str 25, D 53127 Bonn, Germany
    Br J Dermatol 165:1293-302. 2011
    Male-pattern baldness (androgenetic alopecia, AGA) is the most common form of hair loss among humans. Research has shown that it is caused by genetic factors...
  46. ncbi Normalization of mineral ion homeostasis by dietary means prevents hyperparathyroidism, rickets, and osteomalacia, but not alopecia in vitamin D receptor-ablated mice
    Y C Li
    Endocrine Unit, Massachusetts General Hospital, Harvard Medical School, Boston 02114, USA
    Endocrinology 139:4391-6. 1998
    ..VDR-ablated animals fed this diet did not develop rickets or osteomalacia. However, alopecia was still observed in the VDR-ablated mice with normal mineral ions, suggesting that the VDR is required for ..
  47. ncbi Adolescent androgenic alopecia
    Patrick Henry McDonough
    New Jersey Medical School, Newark, NJ 07103, USA
    Cutis 88:165-8. 2011
    Adolescent androgenic alopecia is pattern hair loss occurring in boys and girls younger than 18 years, whereas early-onset androgenic alopecia refers to pattern hair loss before 35 years of age...
  48. ncbi Gsdma3 mutation causes bulge stem cell depletion and alopecia mediated by skin inflammation
    Yue Zhou
    Key Laboratory of Model Animal for Disease Study of Ministry of Education, Model Animal Research Center, Nanjing University, Nanjing, China
    Am J Pathol 180:763-74. 2012
    ..The alopecia and excoriation (AE) mouse strain is a dominant mutant generated from ethyl nitrosourea mutagenesis...
  49. pmc The disruption of Sox21-mediated hair shaft cuticle differentiation causes cyclic alopecia in mice
    Makoto Kiso
    Division of Mammalian Development and Mammalian Genetics, National Institute of Genetics, Mishima, Shizuoka, Japan
    Proc Natl Acad Sci U S A 106:9292-7. 2009
    ..We have established a mutant mouse with a cyclic alopecia phenotype resulting from the targeted disruption of Sox21, a gene that encodes a HMG-box protein...
  50. ncbi S1 guideline for diagnostic evaluation in androgenetic alopecia in men, women and adolescents
    U Blume-Peytavi
    Department of Dermatology and Allergy, Clinical Research Center for Hair and Skin Science, Charite Universitatsmedizin Berlin, Chariteplatz 1, 10117 Berlin, Germany
    Br J Dermatol 164:5-15. 2011
    Androgenetic alopecia (AGA) is the most common hair loss disorder, affecting both men and women...
  51. pmc Primary follicular dystrophy with scarring dermatitis in C57BL/6 mouse substrains resembles central centrifugal cicatricial alopecia in humans
    J P Sundberg
    DVM, PhD, The Jackson Laboratory, Bar Harbor, ME 04609 1500, USA
    Vet Pathol 48:513-24. 2011
    ..One of several B6 strain-specific background diseases is focal alopecia that may resolve or progress to severe, ulcerative dermatitis...
  52. ncbi Treatment of hyperandrogenic alopecia in women
    Enrico Carmina
    Department of Obstetrics and Gynecology, University of Palermo, Palermo, Italy
    Fertil Steril 79:91-5. 2003
    To determine the effectiveness of various antiandrogens for the treatment of premenopausal women with hyperandrogenic alopecia.
  53. ncbi Prevalence and types of androgenetic alopecia in Shanghai, China: a community-based study
    F Xu
    Department of Dermatology, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai 200040, China
    Br J Dermatol 160:629-32. 2009
    There are ethnic differences in the prevalence and types of androgenetic alopecia (AGA)...
  54. ncbi Hypertension and aldosterone levels in women with early-onset androgenetic alopecia
    S Arias-Santiago
    Department of Dermatology, San Cecilio University Hospital, Av Dr Oloriz 16, Granada 18012, Spain
    Br J Dermatol 162:786-9. 2010
    Few studies have analysed the relationship between androgenetic alopecia (AGA) in women and cardiovascular disease...
  55. ncbi Epidermal Cadm1 expression promotes autoimmune alopecia via enhanced T cell adhesion and cytotoxicity
    Adam Giangreco
    Cancer Research UK Cambridge Research Institute, Cambridge CB2 0RE, United Kingdom
    J Immunol 188:1514-22. 2012
    Autoimmune alopecia is characterized by an extensive epidermal T cell infiltrate that mediates hair follicle destruction. We have investigated the role of cell adhesion molecule 1 (Cadm1; Necl2) in this disease...
  56. ncbi Androgenetic alopecia and cardiovascular risk factors in men and women: a comparative study
    Salvador Arias-Santiago
    Dermatology Unit, San Cecilio University Hospital, Granada, Spain
    J Am Acad Dermatol 63:420-9. 2010
    Numerous studies in recent decades have associated male androgenetic alopecia (AGA) with the risk of cardiovascular disease. However, only 3 studies have addressed this association in female patients...
  57. pmc RIN2 deficiency results in macrocephaly, alopecia, cutis laxa, and scoliosis: MACS syndrome
    Lina Basel-Vanagaite
    Schneider Children s Medical Center of Israel and Raphael Recanati Genetics Institute, Rabin Medical Center, Beilinson Campus, Petah Tiqva, Israel
    Am J Hum Genet 85:254-63. 2009
    ..the present study, we report on an autosomal-recessive disorder that we have termed MACS syndrome (macrocephaly, alopecia, cutis laxa, and scoliosis). The disorder was mapped to chromosome 20p11.21-p11...
  58. pmc Mouse models for human hair loss disorders
    Rebecca M Porter
    Cancer Research UK Cell Structure Research Group, School of Life Sciences, MSI WTB complex, University of Dundee, Dundee DD1 5EH, UK
    J Anat 202:125-31. 2003
    ..Future studies of mouse hair-loss mutants are likely to benefit the understanding of human hair loss as well as increasing our knowledge of mechanisms controlling morphogenesis and tumorigenesis...
  59. ncbi Topical tacrolimus (FK506): treatment failure in four cases of alopecia universalis
    Sung Wook Park
    Acta Derm Venereol 82:387-8. 2002
  60. ncbi Effect of minoxidil on proliferation and apoptosis in dermal papilla cells of human hair follicle
    Ji Hyun Han
    Department of Dermatology, Clinical Research Institute, Seoul National University College of Medicine, Seoul National University Hospital, 28 Yongon Dong, Chongno Gu, Seoul 110 744, South Korea
    J Dermatol Sci 34:91-8. 2004
    Minoxidil has been widely used to treat androgenetic alopecia, but little is known about its pharmacological activity or about the identity of its target cells in hair follicles...
  61. pmc Asebia-2J (Scd1(ab2J)): a new allele and a model for scarring alopecia
    J P Sundberg
    Jackson Laboratory, Bar Harbor, Maine 04609 1500, USA
    Am J Pathol 156:2067-75. 2000
    A spontaneous, autosomal, recessive mouse mutation exhibiting mild scaly skin, progressive scarring alopecia, slightly runted growth, and photophobia arose at The Jackson Laboratory in 1993 in the inbred mouse strain DBA/1LacJ...
  62. ncbi Evaluation and treatment of male and female pattern hair loss
    Elise A Olsen
    Duke University Medical Center, Durham, North Carolina 27710, USA
    J Am Acad Dermatol 52:301-11. 2005
  63. ncbi Dermoscopy patterns of cicatricial alopecia resulting from discoid lupus erythematosus and lichen planopilaris
    Bruna Duque-Estrada
    Sociedade Brasileira de Dermatologia, Rio de Janeiro, RJ, Brasil
    An Bras Dermatol 85:179-83. 2010
    ..Dermoscopy is an important tool for the diagnosis of benign and malignant melanocytic diseases. Recently, this method has also been found to be extremely useful in the diagnosis and follow-up of alopecias...
  64. ncbi A phase I study of topical Tempol for the prevention of alopecia induced by whole brain radiotherapy
    James M Metz
    Department of Radiation Oncology, University of Pennsylvania, Philadelphia 19104 4283, USA
    Clin Cancer Res 10:6411-7. 2004
    Complete alopecia is a universal complication of whole brain radiation therapy which contributes to patient anxiety over treatment...
  65. ncbi Human equivalent of the mouse Nude/SCID phenotype: long-term evaluation of immunologic reconstitution after bone marrow transplantation
    C Pignata
    Department of Pediatrics and Cellular and Molecular Biology and Pathology, Federico II University, Naples, Italy
    Blood 97:880-5. 2001
    ..The disease is characterized by a T-cell defect, congenital alopecia, and nail dystrophy...
  66. pmc Retinol Esterification by DGAT1 Is Essential for Retinoid Homeostasis in Murine Skin
    Michelle Y S Shih
    Gladstone Institute of Cardiovascular Disease, San Francisco, California 94158, USA
    J Biol Chem 284:4292-9. 2009
    ..Deletion of the enzyme specifically in the epidermis causes alopecia, indicating that the regulation of RA homeostasis by DGAT1 is autonomous in the epidermis...
  67. ncbi Minoxidil: mechanisms of action on hair growth
    A G Messenger
    Department of Dermatology, Royal Hallamshire Hospital, Sheffield S10 2JF, UK
    Br J Dermatol 150:186-94. 2004
    ..In this article we review the current state of knowledge on the mode of action of minoxidil on hair growth and indicate lines of future research...
  68. ncbi The importance of dual 5alpha-reductase inhibition in the treatment of male pattern hair loss: results of a randomized placebo-controlled study of dutasteride versus finasteride
    Elise A Olsen
    Duke University Medical Center, Durham, North Carolina, USA
    J Am Acad Dermatol 55:1014-23. 2006
    ..Male pattern hair loss (MPHL) is a potentially reversible condition in which dihydrotestosterone is an important etiologic factor...
  69. ncbi [Long-term follow-up of the efficacy of methotrexate alone or in combination with low doses of oral corticosteroids in the treatment of alopecia areata totalis or universalis]
    E Chartaux
    Clinique Dermatologique, CHU de Rouen, Universite de Rouen, 1, rue de Germont, 76000 Rouen, France
    Ann Dermatol Venereol 137:507-13. 2010
    Treatment of severe and chronic forms of alopecia areata (AA) totalis remains difficult. It has been suggested that methotrexate (MTX) is an efficacious treatment for AA totalis...
  70. ncbi Burden of hair loss: stress and the underestimated psychosocial impact of telogen effluvium and androgenetic alopecia
    Ina M Hadshiew
    Department of Dermatology, University Hospital Hamburg Eppendorf, University of Hamburg, Martinistrasse 52, 20246 Hamburg, Germany
    J Invest Dermatol 123:455-7. 2004
    Hair loss, as it occurs with telogen effluvium and androgenetic alopecia, provokes anxieties and distress more profound than its objective severity would appear to justify...
  71. pmc Inactivation of the integrin beta 6 subunit gene reveals a role of epithelial integrins in regulating inflammation in the lung and skin
    X Z Huang
    Lung Biology Center, University of California, San Francisco 94143, USA
    J Cell Biol 133:921-8. 1996
    ..Genetic or acquired alterations in this integrin could thus contribute to the development of inflammatory diseases of epithelial organs, such as the lungs and skin...
  72. ncbi Phospholipase C-delta1 is an essential molecule downstream of Foxn1, the gene responsible for the nude mutation, in normal hair development
    Yoshikazu Nakamura
    Laboratory of Genome and Biosignal, Tokyo University of Pharmacy and Life Sciences, 1432 1 Horinouchi, Hachioji, 192 0392 Tokyo, Japan
    FASEB J 22:841-9. 2008
    ..These results indicate that PLC-delta1 is an essential molecule downstream of Foxn1 in normal hair formation, and strongly suggest that hairlessness in nude mice is caused by insufficient expression of PLC-delta1...
  73. ncbi 'Cyclic alopecia' in Msx2 mutants: defects in hair cycling and hair shaft differentiation
    Liang Ma
    Division of Genetics, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Development 130:379-89. 2003
    ..Thus, the combinatorial defects in hair cycling and differentiation, together with concealed skin domains, account for the cyclic alopecia phenotype.
  74. ncbi Chemotherapy-induced alopecia
    Ralph M Trueb
    Department of Dermatology, University Hospital of Zurich, Gloriastr 31, CH 8091, Zurich, Switzerland
    Semin Cutan Med Surg 28:11-4. 2009
    Few dermatologic conditions carry as much emotional distress as chemotherapy-induced alopecia (CIA). The prerequisite for successful development of strategies for CIA prevention is the understanding of the pathobiology of CIA...
  75. ncbi Overexpression of Hoxc13 in differentiating keratinocytes results in downregulation of a novel hair keratin gene cluster and alopecia
    A V Tkatchenko
    Department of Medicine, Medical University of South Carolina, Charleston, SC 29425, USA
    Development 128:1547-58. 2001
    ..We show that transgenic mice overexpressing Hoxc13 in differentiating keratinocytes of hair follicles develop alopecia, accompanied by a progressive pathological skin condition that resembles ichthyosis...
  76. ncbi The histopathology of primary cicatricial alopecia
    Leonard C Sperling
    Department of Dermatology, Uniformed Services University, Bethesda, MD 20814, USA
    Semin Cutan Med Surg 25:41-50. 2006
    b>Alopecia typically is divided into cicatricial (scarring) and noncicatricial (nonscarring) forms. "Scarring" alopecia implies that follicular epithelium has been replaced by connective tissue and is therefore an irreversible process...
  77. ncbi A randomized clinical trial of 5% topical minoxidil versus 2% topical minoxidil and placebo in the treatment of androgenetic alopecia in men
    Elise A Olsen
    Duke Dermatopharmacology Study Center, Durham, North Carolina, USA
    J Am Acad Dermatol 47:377-85. 2002
    ..minoxidil solution 2% stimulates new hair growth and helps stop the loss of hair in individuals with androgenetic alopecia (AGA)...
  78. ncbi Colocalization of alopecia areata and vitiligo
    B B Adams
    Department of Dermatology, University of Cincinnati, College of Medicine, Ohio, USA
    Pediatr Dermatol 16:364-6. 1999
    We report an 18-year-old woman who had a 4-month history of colocalization of alopecia areata and vitiligo, principally on the occipital portion of the scalp.
  79. ncbi Histological features of peripilar signs associated with androgenetic alopecia
    Claire Deloche
    Centre Charles Zviak, L Oreal Recherche, 90 rue du General Roguet, 92583 Clichy Cedex, France
    Arch Dermatol Res 295:422-8. 2004
    A study of the scalp in a large cohort of volunteers with androgenetic alopecia using macrophotographs showed the presence of peripilar signs (PPS) around the hair ostia.
  80. ncbi Anti-alopecia mechanisms of soymetide-4, an immunostimulating peptide derived from soy beta-conglycinin
    Takahiro Tsuruki
    Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Uji, Kyoto 611 0011, Japan
    Peptides 26:707-11. 2005
    ..soymetide-4 (MITL), an immunostimulating peptide derived from soybean beta-conglycinin alpha' subunit, suppressed alopecia induced by the anti-cancer drug etoposide in neonatal rats...
  81. ncbi Strategies of coping and quality of life in women with alopecia
    S Schmidt
    Institute of Medical Psychology, University Hospital of the Friedrich Schiller University Jena, Stoystrasse 3, D 07740 Jena, Germany
    Br J Dermatol 144:1038-43. 2001
    ..Our hypothesis is that QoL in patients with certain diseases can be affected by strategies of coping behaviour, as well as by personality traits...
  82. ncbi [Post-thymus transplant vitiligo in a child with Foxn1 deficiency]
    E Levy
    Clinique Dermatologique, Hopital Civil, Centre Hospitalier Universitaire de Strasbourg, 1, Place de l Hopital, BP 426, 67091 Strasbourg Cedex, France
    Ann Dermatol Venereol 139:468-71. 2012
    ..Foxn1 transcription factor deficit leads to immune deficiency, with hair and nail abnormalities. We report the case of a patient also presenting localized leucoderma...
  83. ncbi Management of primary cicatricial alopecias: options for treatment
    M J Harries
    The Dermatology Centre, The University of Manchester, Hope Hospital, Manchester M6 8HD, UK
    Br J Dermatol 159:1-22. 2008
    ..Early treatment is the key to minimizing the extent of permanent alopecia. However, inconsistent terminology, poorly defined clinical end-points and a lack of good quality clinical trials ..
  84. pmc The role of vitamin D receptor mutations in the development of alopecia
    Peter J Malloy
    Stanford University School of Medicine, Stanford, CA 94305 5103, USA
    Mol Cell Endocrinol 347:90-6. 2011
    ..An interesting additional abnormality is the presence of alopecia in some children depending on the nature of the VDR mutation...
  85. ncbi Illness perceptions, coping and quality of life in patients with alopecia
    T Cartwright
    Department of Psychology, University of Westminster, London W1B 2UW, UK
    Br J Dermatol 160:1034-9. 2009
    b>Alopecia can have substantial psychological consequences, but there has been no research looking at patients' beliefs about their condition nor how they relate to quality of life (QoL).
  86. pmc Lipids to the top of hair biology
    Kurt S Stenn
    Aderans Research Institute, Inc, Philadelphia, Pennsylvania, USA
    J Invest Dermatol 130:1205-7. 2010
    ..A direct link was made to at least one form of cicatricial alopecia, but the role lipids play in other follicular pathologies, such as the acneiform conditions, are inadequately ..
  87. ncbi Alopecia and mood stabilizers: two case reports
    C Uehlinger
    Hôpital Psychiatrique Cantona, Perreux Neuchätel, Switzerland
    Eur Arch Psychiatry Clin Neurosci 242:85-8. 1992
    Two cases of alopecia observed during treatment with lithium and valproate are described, and the recent literature on this subject is reviewed. Our clinical observations confirm earlier reports...
  88. ncbi Hair grooming practices and central centrifugal cicatricial alopecia
    Raechele Cochran Gathers
    Multicultural Dermatology Center, Department of Dermatology, Henry Ford Hospital, Detroit, Michigan 48202, USA
    J Am Acad Dermatol 60:574-8. 2009
    The cause of central centrifugal cicatricial alopecia (CCCA) in African American women remains to be elucidated.
  89. ncbi Steroidogenic isoenzymes in human hair and their potential role in androgenetic alopecia
    Rolf Hoffmann
    Department of Dermatology, Philipp University, Marburg, Germany
    Dermatology 206:85-95. 2003
    Androgenetic alopecia (AGA) is the most common type of hair loss...
  90. ncbi Linear polarized infrared irradiation using Super Lizer is an effective treatment for multiple-type alopecia areata
    Masashi Yamazaki
    Department of Dermatology, Juntendo University School of Medicine, Tokyo, Japan
    Int J Dermatol 42:738-40. 2003
    ..Super Lizer trade mark is a linear polarized light instrument, which has been used with good effect in orthopedics and anesthesiology to treat arthralgia and neuralgia with a high output of infrared radiation...
  91. ncbi Androgen receptor gene polymorphisms and risk for androgenetic alopecia: a meta-analysis
    F L Zhuo
    Department of Dermatology, Beijing Friendship Hospital, Capital Medical University, Beijing, China
    Clin Exp Dermatol 37:104-11. 2012
    Numerous studies have shown an association between polymorphisms in the androgen receptor gene (AR) and the risk for androgenetic alopecia (AGA), but the overall results are still controversial.
  92. ncbi Insights from the asebia mouse: a molecular sebaceous gland defect leading to cicatricial alopecia
    K S Stenn
    Juvenir Biosciences, Inc, Inc, Skillman, New Jersey 08558 9418, USA
    J Cutan Pathol 28:445-7. 2001
    ..Recent work with the mouse mutant, asebia, provides a model for cicatricial alopecia. In this model the pathology--perifollicular inflammation, sebaceous gland "destruction", hair shaft granuloma, ..
  93. ncbi Pressure alopecia following vitreoretinal surgery
    Harit K Bhatt
    Vitreoretinal Service of the Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago, 60612, USA
    Am J Ophthalmol 137:191-3. 2004
    To describe a patient with pressure alopecia following vitreoretinal surgery.
  94. ncbi Acute diffuse and total alopecia of the female scalp. A new subtype of diffuse alopecia areata that has a favorable prognosis
    Maki Sato-Kawamura
    Department of Dermatology, Tohoku University School of Medicine, Sendai, Japan
    Dermatology 205:367-73. 2002
    Although alopecia areata (AA) usually starts with focal lesions of hair loss and then presents several different clinical forms, AA may begin as diffuse hair loss...
  95. ncbi The triple rotation scalp flap revisited: a case of reconstruction of cicatricial pressure alopecia
    I G Michaelidis
    Department of Oral and Maxillofacial Surgery, 401 Army Hospital, Athens, Greece
    Int J Oral Maxillofac Surg 35:1153-5. 2006
    ..A case of cicatricial pressure alopecia that was successfully repaired using the Bardach modification of the curved tripod flap confirms the value of ..
  96. ncbi Alopecia in congenital hidrotic ectodermal dysplasia responding to treatment with a combination of topical minoxidil and tretinoin
    Shubha Melkote
    Department of Dermatology, LTM Medical College and General Hospital, Sion, Mumbai, India
    Int J Dermatol 48:184-5. 2009
    Clouston's syndrome is an ectodermal dysplasia characterized by dystrophic nails, alopecia, and palmoplantar hyperkeratosis. Alopecia is due to decrease in number and degree of maturation of the hair follicles...
  97. ncbi Alopecia in children after cardiac surgery
    D Ben-Amitai
    Department of Pediatrics A, Beilinson Medical Center, Petah Tiqva, Israel
    Pediatr Dermatol 10:32-3. 1993
    Postoperative alopecia is an uncommon complication of surgery and is reported mainly in adults who undergo prolonged anesthesia. The disorder occurred in three infants after cardiac surgery...
  98. ncbi 5alpha-Reductase type 2 gene variant associations with prostate cancer risk, circulating hormone levels and androgenetic alopecia
    Vanessa M Hayes
    Cancer Research Program, Garvan Institute of Medical Research, St Vincent s Hospital, Sydney, Australia
    Int J Cancer 120:776-80. 2007
    ..to examine the association of these variants with prostate cancer risk, plasma hormone levels and androgenetic alopecia. Subjects include 827 cases and 736 controls from an Australian population-based case-control study of prostate ..
  99. ncbi Central centrifugal cicatricial alopecia: past, present, and future
    Raechele Cochran Gathers
    Multicultural Dermatology Center, Department of Dermatology, Henry Ford Hospital, Detroit, Michigan 48202, USA
    J Am Acad Dermatol 60:660-8. 2009
    Clinical scarring alopecia in African American women has been recognized for years. The classification of this unique form of alopecia dates back to Lopresti, who first described the entity called "hot comb alopecia...
  100. ncbi Madarosis and facial alopecia presumed secondary to botulinum a toxin injections
    Dianne Kowing
    William Chappell Jr VA Outpatient Clinic, Daytona Beach, FL 32114 1495, USA
    Optom Vis Sci 82:579-82. 2005
    ..Botulinum neurotoxins are considered relatively safe therapy for treatment of inappropriate muscle spasms. As seen in this report, undesirable consequences may result...
  101. ncbi Role of androgens in female-pattern androgenetic alopecia, either alone or associated with other symptoms of hyperandrogenism
    P Vexiau
    Endocrinology Service, H pital Saint Louis, Paris, France
    Arch Dermatol Res 292:598-604. 2000
    The roles of androgen hypersecretion, in situ enzyme activity, and androgen receptors in androgenetic alopecia in women are still a matter of debate...

Research Grants65

  1. A Soft Topical Antiandrogenic Drug
    Wei Chu Xu; Fiscal Year: 2013
    ..The overproduction of androgens in both sexes is the root cause of most acne (acne vulgaris), alopecia and seborrhea, and the practice of using antiandrogenic therapy in these disorders is accepted...
  2. Somatic Stem Cells in Engineered Human Skin
    Steven Boyce; Fiscal Year: 2009
    ..for replacement of hair and glands in burned skin with the potential to address conditions such as burn alopecia and thermal regulation...
  3. Mechanistic Characterization and Genetic Analysis of Systemic Iron Homeostasis
    Xin Du; Fiscal Year: 2011
    ..This work was aimed at the understanding of mask, an ENU-induced phenotype characterized by progressive alopecia and microcytic anemia, and iron deficiency in mice...
  4. Cicatricial Alopecia Research Symposium 2011: Lipids, Inflammation &Stem Cells
    Pratima Karnik; Fiscal Year: 2011
    DESCRIPTION (provided by applicant): The Cicatricial Alopecia Research Symposium hosted by Case Western Reserve University (CWRU) School of Medicine (SOM) has become the premier forum for presentation and discussion of the most recent ..
  5. Roles of Hox genes in skin and hair follicle development
    Alexander Awgulewitsch; Fiscal Year: 2010
    ..transgenic mice created by us and Hoxc13 null mice exhibit severe hair growth defects resulting in alopecia. DMA microarray analysis of the transgenic mice and subsequent validation by various methods identified Foxql and ..
  6. Genetics of Alopecia Areata in the C3H/HeJ Mouse
    JOHN PAUL SUNDBERG; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Alopecia areata (AA) is a disfiguring human autoimmune skin disease with a complex genetic basis that targets hair follicles in the actively growing anagen phase and is often associated with other ..
  7. DEVELOPMENT AND REGENERATION OF SKIN APPENDAGES
    Cheng Ming Chuong; Fiscal Year: 2013
    ..This flexible model can accommodate physiological and pathological phenomena ranging from aging alopecia to seasonal molting...
  8. PPAR-gamma Signaling in Normal Pilosebaceous Units and in Scarring Alopecia
    Pratima Karnik; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): PPAR-gamma Signaling in Normal Pilosebaceous Units (PSU) and in Scarring Alopecia ABSTRACT Primary cicatricial or scarring alopecia (CA) are characterized by a folliculocentric inflammation with the ..
  9. Genome Wide Association Studies in Alopecia Areata
    Angela M Christiano; Fiscal Year: 2012
    The long-term goal of this Project is to identify the genetic variation contributing to the risk of developing Alopecia Areata (AA). AA is one of the most common human autoimmune diseases, with a lifetime risk of approximately 2%...
  10. Identification of Alopecia Areata Biomarkers in Skin and Blood
    Angela M Christiano; Fiscal Year: 2012
    ..by applicant): The goal of this application is to define a translational platform of candidate biomarkers for Alopecia Areata (AA)...
  11. Extrinsic Regulation of Epidermal Homeostatasis
    Valerie Horsley; Fiscal Year: 2013
    ..Patients with alopecia, hair shaft disorders, or chronic wounds could potentially benefit from this research.
  12. Regulation of Quiescence and Activation in Skin Stem Cells
    Ya Chieh Hsu; Fiscal Year: 2013
    ..Dis-regulation of HFSC activity results in severe consequences. For example, alopecia (hair loss) and delayed wound healing may arise from inefficient activation of HFSCs...
  13. Characterizing interactions of the VDR and the canonical Wnt signatling pathway
    Hilary F Luderer; Fiscal Year: 2010
    ..In addition to Rickets, multiple inherited VDR mutations result in alopecia totalis. VDR null mice phenocopy the human disease...
  14. Planar Cell Polarity Signaling in Hair Follicle Formation
    Jiang Chen; Fiscal Year: 2013
    ..pathway during hair follicle formation, and may provide new insights into the development of hair and other skin diseases such as alopecia and BCC, based on which novel treatment strategies for these skin conditions may be developed.
  15. GENETIC ANALYSIS OF LUPUS AUTOIMMUNITY
    Judith James; Fiscal Year: 2000
    ..of human lupus including proteinuria, red cell casts, renal insufficiency, hypoalbuminemia, thrombocytopenia, alopecia, and seizures...
  16. The role of prostaglandin d2 in hair follicle biology
    LUIS ANDRES GARZA; Fiscal Year: 2012
    ..We have discovered correlations both in mouse (K14-COX2 transgenic) and man (androgenetic alopecia) of elevations in PGDa levels and the phenotype of hair miniaturization and sebaceous hyperplasia...
  17. Cellular Mechanisms in Hutchinson-Gilford Progeria Syndrome and Normal Aging
    Kan Cao; Fiscal Year: 2012
    ..Patients with HGPS appear normal at birth, but begin to display alopecia, growth retardation, bone abnormalities, osteoporosis, and sclerodermatous skin by one year of age...
  18. THE ROLE OF IL-31 IN TH2 CYTOKINE-DRIVEN SYSTEMIC SCLEROSIS
    Satish K Madala; Fiscal Year: 2013
    ..by activated Th2 T cells and overproduction of IL-31 in mouse skin has been shown to cause severe pruritus, alopecia and skin lesions similar to those seen in SSc...
  19. The Vitamin D Receptor:ligand-dependent and independent actions
    Marie Demay; Fiscal Year: 2013
    ..Like humans with VDR mutations, VDR null mice develop alopecia. We have demonstrated that the ligand-independent actions of the VDR are required for hair follicle keratinocyte ..
  20. Premature Aging, Vascular Disease and Endothelial Mechanotransduction
    WILLIAM JAMES ADAMS; Fiscal Year: 2012
    ..to the dysfunction of multiple organ systems characterized by features of normal aging such as osteoporosis, alopecia and skin wrinkling...
  21. Craniofacial Gene Discovery in Mice
    Leah Rae B Donahue; Fiscal Year: 2010
    ..They are: a) Nm3768, a semi-dominant mutation displaying preaxial polydactlyly, a short nose, dorsal alopecia, abnormal frontal bone development, and eyes open at birth;b) Nm3437, a semi-dominant mutation exhibiting a short ..
  22. VITAMIN D RECEPTOR AND REGULATION OF HORMONE RESPONSE
    David Feldman; Fiscal Year: 2010
    ..Mutations in the hairless gene cause a syndrome of alopecia with papular lesions (APL) that is virtually identical to the alopecia in HVDRR...
  23. Characterization of Pathogenic T cells in Alopecia Areata
    EMANUAL M MAVERAKIS; Fiscal Year: 2012
    ..the gap that hitherto existed in understanding the effector mechanisms of an autoreactive immune response, using alopecia areata as a prototypic example...
  24. Polarization of Adult Stem Cells, the Role of Vangl in Skin Homeostasis and Cance
    RYAN WILLIAM FIEHLER; Fiscal Year: 2012
    ..These processes may be disrupted in skin related disease such as psoriasis, alopecia and chronic ulcers...
  25. Interfollicular epidermal stem cells in human and mouse skin
    DENISE LEA GAY; Fiscal Year: 2011
    ..of skin and HF regeneration, and provide a powerful new tool for therapeutic treatment of chronic wounds and alopecia. PUBLIC HEALTH RELEVANCE: We will study stem cells in the outer portion of the skin called the epidermis...
  26. Positional cloning of mutations that disrupt hair development in mice.
    Thomas R King; Fiscal Year: 2011
    ..in a set of recessive mutations that cause defective hair and skin development in mice, including: juvenile alopecia (jal), wooly (wly), frizzy-like (frzl), retarded hair growth (rhg), follicular dystrophy (fold), and wellhaarig (..
  27. The Genetic Basis of the GAPO Progeroid Syndrome
    Calum A Macrae; Fiscal Year: 2013
    ..One unique form of aging, that to date has not been studied at the molecular level, is the Growth retardation, Alopecia, Pseudoanodontia, and Optic atrophy (or GAPO) syndrome...
  28. PHARMACOLOGY AND EFFICACY OF NOVEL TAXOL FORMULATIONS
    ROBERT STRAUBINGER; Fiscal Year: 1999
    ..Myelosuppression, peripheral and sensory neuropathy, gastrointestinal epithelial necrosis, and alopecia are examples of delayed toxicity...
  29. Hair Follicle Neogenesis in Response to Wounding
    George Cotsarelis; Fiscal Year: 2013
    ..Ultimately, our findings will yield insights into scarless wound healing tht have implications for understanding skin biology and developing future treatments for wounds, alopecia and other degenerative skin disorders.
  30. Tissue Engineering of New Hair Formation
    Cheng Ming Chuong; Fiscal Year: 2013
    ..The development of this technology will bring new hope to those who suffer from severe wounds and alopecia. PUBLIC HEALTH RELEVANCE: Currently, over 100,000 patients are treated for burn injury in the United States per ..
  31. STEROID 5 ALPHA REDUCTASE--STRUCTURE/FUNCTION
    Shutsung Liao; Fiscal Year: 2000
    ..in a variety of androgen-dependent pathological conditions including benign prostatic hyperplasia, acne, alopecia, and female idiopathic hirsutism...
  32. FUNCTION OF NOGGIN IN HAIR FOLLICLE GROWTH AND DISEASE
    Vladimir Botchkarev; Fiscal Year: 2006
    Despite different pathogenic mechanisms, most common hair growth disorders (androgenic alopecia and alopecia areata) are characterized by the development of hair follicle miniaturization with significant elongation of the resting stage, ..
  33. MOUSE MODEL OF EOSINOPHIL MEDIATED SKIN PATHOLOGY
    James Lee; Fiscal Year: 1999
    ..Transgenic animals also show evidence of an increased frequency of hair-loss (alopecia). In addition, a subset of these animals spontaneously develop necrosing ulcerations of the skin...
  34. A ROLE FOR NOGGIN AND BMP2/4 IN HAIR GROWTH CONTROL
    Vladimir Botchkarev; Fiscal Year: 2003
    Background: Despite different pathogenic mechanisms, two of the most common hair growth disorder (androgenic alopecia and alopecia areata) are characterized by hair follicle miniaturization with significant elongation of the resting stage,..
  35. SEROLOGICAL EXPRESSION ANALYSIS OF VITILIGO AND ALOPECIA
    Vijayasaradhi Setaluri; Fiscal Year: 2001
    ..Vitiligo, characterized by partial or complete loss of skin pigmentation and alopecia areata, a chronic inflammatory hair disorder are two such diseases...
  36. Hutchinson Gilford Progeria Syndrome and Atherosclerosis
    Stephen Young; Fiscal Year: 2009
    ..HGPS patients have many aging-like phenotypes, including a wizened appearance, alopecia, osteoporosis, and coronary heart disease...
  37. HAIR FOLLICLE BULGE CELLS IN TUMORIGENESIS AND ALOPECIA
    George Cotsarelis; Fiscal Year: 2009
    ..Patients with alopecia, hair shaft disorders, basal cell carcinoma, hair follicle tumors, or chronic wounds could potentially benefit ..
  38. Annual Meeting of the Androgen Excess Society
    Ricardo Azziz; Fiscal Year: 2009
    ..These disorders result in infertility, hirsutism, acne and androgen alopecia, menstrual abnormalities, and are associated with an increased risk for endometrial cancer and diabetes...
  39. Transcription factor function of hairless
    Andrew Engelhard; Fiscal Year: 2005
    ..In the case of hr mutations, which cause alopecia in mice and other animals and atrichia with papular lesions (APL, OMIM 209500) in humans, cellular and ..
  40. CHARACTERIZATION OF BIOTINIDASE DEFICIENCY
    Barry Wolf; Fiscal Year: 1992
    ..individuals may exhibit neurologic and cutaneous features including seizures, hypotonia, ataxia, skin rash, alopecia and developmental delay, which may progress to come and ultimately death...
  41. FUNGAL PROTEIN/GLYCOPROTEIN EXPRESSION IN TINEA CAPITIS
    Susan Abdel Rahman; Fiscal Year: 2003
    ..in academic and social activities and 4) psychological concerns surround those children who develop permanent alopecia as a result of infection...
  42. PREVENTION OF CHEMOTHERAPY-INDUCED HAIR LOSS
    Joaquin Jimenez; Fiscal Year: 2005
    ..Most therapeutic combinations include anti-neoplastic agents that cause loss of scalp hair (chemotherapy-induced alopecia)...
  43. Role of a Novel Corepressor in Nuclear Receptor Action
    Nicholas Marsh Armstrong; Fiscal Year: 2010
    ..HR functions in many tissues, most prominently in skin as mutations in the Hr gene cause (alopecia) hair loss in humans and mice...
  44. GENETIC ANALYSIS OF ALOPECIA AREATA
    Mariza de Andrade; Fiscal Year: 2000
    b>Alopecia Areata, patchy hair loss which may progress to total scalp or body hair loss, affects 1-2 percent of the population...
  45. Search for Susceptibility Genes in Alopecia Areata
    Jianhong Mo; Fiscal Year: 2006
    b>Alopecia areata (AA) affects approximately 4...
  46. ALOPECIA AREATA REGISTRY
    Madeleine Duvic; Fiscal Year: 2000
    b>Alopecia Areata is a fairly common disease in which hair is lost either from part of the scalp, all of the scalp or the entire body. In some cases the disease is hereditary. It is thought to be an autoimmune disease...
  47. 4th International Research Workshop on Alopecia Areata
    ROBERT LAVKER; Fiscal Year: 2002
    The Fourth International Research Workshop on Alopecia Areata will bring together investigators working in this field...
  48. LIPOSOMES FOR DELIVERY OF DRUGS TO HAIR-FOLLICLE CELLS
    Lingna Li; Fiscal Year: 1992
    ..There is a need to stimulate hair growth for various conditions of alopecia. It is asserted that to achieve hair growth stimulation, biologically active compounds must be delivered inside ..
  49. MOLECULAR AND STRUCTURAL BIOLOGY OF HAIR GROWTH
    Kurt Stenn; Fiscal Year: 1990
    ..of either group the studies and related conferences have, in general, focused on applied issues: therapeutics of alopecia or hirsutism in the former and shaft characteristics in the latter...
  50. CHARACTERIZATION OF HAIRLESS ASSOCIATED PROTEINS
    Karima Djabali; Fiscal Year: 2004
    ..of the first two genes directly implicated in human hair growth regulation, both of which result in complete alopecia. One of these genes, the hairless gene, is one of the candidate genes for the regulation of basic hair follicle ..
  51. Creating an experimental animal model of alopecia areata
    Lawrence Chan; Fiscal Year: 2002
    b>Alopecia areata is a chronic autoimmune hair loss disorder that affects 0.2-2 % of population. Although alopecia areata is a non-fatal disease, the disease itself and the treatment complication can cause significant morbidity...
  52. A SPLIT-SELECTABLE MARKER FOR MULTIGENE TRANSFORMATIONS
    LLOYD YU; Fiscal Year: 2001
    ..often suffer hair loss and we plan to develop DoxoRx into a topically applied product to prevent this form of alopecia. When administered orally, DoxoRx may also combat mucositis, which is another side effect of anthracycline- based ..
  53. Sixteenth Ovarian Workshop
    Teresa Woodruff; Fiscal Year: 2007
    ..impacts ovarian function; steroid excess, including hyperandrogenic states leading to hirsutism; acne and alopecia; infertility treatments for women with ovarian dysfunction; preservation of fertility for women with cancer; the ..
  54. MOLECULAR CHARACTERIZATION OF HAIR FOLLICLE STEM CELLS
    George Cotsarelis; Fiscal Year: 2000
    ..Additionally, patients with disorders of proliferating tissues such as alopecia, basal cell carcinoma, chronic wounds, or oligospermia may ultimately benefit from this research.
  55. MAPPING OF GENES FOR ALOPECIA IN THE GENERAL POPULATION
    Sudha Iyengar; Fiscal Year: 2000
    This is a pilot grant to examine the genetic basis of alopecia areata. The overall goal of this project is to determine if candidate genes play a substantial role in development of alopecia areata in the general population...
  56. DEVELOPMENT OF POLY-L-GLUTAMIC ACID PACLITAXEL CONJUGATE
    Sidney Wallace; Fiscal Year: 2005
    ..tumors demonstrated safety and tolerability in dose up to 266 mg equivalent paclitaxel/m2 without significant alopecia. This Phase II STTR proposes a Phase I/II clinical trial of CT-213 given concurrently with chest RT in patients ..
  57. THERAPY FOR CHEMOTHERAPY ALOPECIA WITH PTHRP ANALOGS
    Michael Holick; Fiscal Year: 2000
    The goal of this research program is to develop a new approach for preventing and treating chemotherapy induced alopecia. This is being accomplished by evaluating the safety and efficacy of topically administering a parathyroid hormone ..
  58. MOLECULAR CHARACTERIZATION--EPIDERMAL GERMINATIVE CELLS
    Laure Aurelian; Fiscal Year: 1999
    ..They are important in stem cell based gene therapy. Patients with disorders of proliferating tissues such as alopecia, basal cell carcinoma and chronic wounds may also benefit from these studies.
  59. GENETIC ANALYSIS OF ALOPECIA AREATA
    Angela Christiano; Fiscal Year: 2009
    b>Alopecia areata (AA) affects approximately 4.6 million individuals in the United States alone, including males and females of all ages and ethnic groups. Despite its high incidence, its pathomechanism is largely unknown...
  60. MOUSE ALOPECIA AREATA: GENETICS AND MECHANISMS
    John Sundberg; Fiscal Year: 2000
    Our long term goal is to elucidate the immunologic and genetic basis of alopecia areata (AA). Towards this end, we have recently developed a mouse model of the human disease...
  61. Biochemical characterization of hairless associated proteins
    Karima Djabali; Fiscal Year: 2007
    ..of the first two genes directly implicated in human hair growth regulation, both of which result in complete alopecia. One of these genes, the hairless gene, is one of the candidate genes for the regulation of basic hair follicle ..
  62. SHH INDUCTION OF POST-NATAL HAIR FOLLICLE/HAIR GROWTH
    PHILIP LEOPOLD; Fiscal Year: 2004
    ..which is a major social concern associated with more common male-pattern baldness as well as more rare forms of alopecia and chemotherapy...
  63. Transcription regulation in the hairless pathway
    Andrew Engelhard; Fiscal Year: 2009
    ..Mutations in the hairless (hr) gene, which cause alopecia in mice and other animals and atrichia with papular lesions (APL, OMIM 209500) in humans, result in cellular and ..
  64. FGFs to Broadly Protect Chemotherapy-Induced Alopecia
    Ze Lu; Fiscal Year: 2005
    Chemotherapy-induced alopecia (CIA) is one of the most common and psychologically distressing side effects of cancer chemotherapy. CIA consists of hair loss, reduced hair growth, and structural abnormalities in the newly grown hair...
  65. DEVELOPMENT OF A NOVEL AGENT FOR TREATMENT OF ALOPECIA
    Wolfgang Gallwitz; Fiscal Year: 2000
    ..problem of male pattern baldness and hair loss which is common in the elderly, but also those patients who suffer alopecia as a consequence of cancer chemotherapy...