sinusitis

Summary

Summary: An inflammatory process of the mucous membranes of the paranasal sinuses that occurs in three stages: acute, subacute, and chronic. Sinusitis results from any condition causing ostial obstruction or from pathophysiologic changes in the mucociliary transport mechanism.

Top Publications

  1. ncbi Clinical practice guideline: adult sinusitis
    Richard M Rosenfeld
    Department of Otolaryngology, SUNY Downstate Medical Center and Long Island College Hospital, Brooklyn, NY 11201 5514, USA
    Otolaryngol Head Neck Surg 137:S1-31. 2007
  2. ncbi EPOS 2012: European position paper on rhinosinusitis and nasal polyps 2012. A summary for otorhinolaryngologists
    Wytske J Fokkens
    Department of Otorhinolaryngology, Academic Medical Center, Amsterdam, The Netherlands
    Rhinology 50:1-12. 2012
  3. ncbi Microbiology of sinusitis
    Itzhak Brook
    Georgetown University School of Medicine, Washington DC, USA
    Proc Am Thorac Soc 8:90-100. 2011
  4. ncbi Chronic rhinosinusitis in Europe--an underestimated disease. A GA²LEN study
    D Hastan
    Department of Otorhinolaryngology, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands
    Allergy 66:1216-23. 2011
  5. ncbi Role of staphylococcal superantigens in upper airway disease
    Claus Bachert
    Upper Airway Research Laboratory, Ear Nose and Throat Department, University Hospital Ghent, Ghent, Belgium
    Curr Opin Allergy Clin Immunol 8:34-8. 2008
  6. ncbi Staphylococcus aureus invades the epithelium in nasal polyposis and induces IL-6 in nasal epithelial cells in vitro
    F Sachse
    Department of Otorhinolaryngology, University Hospital Munster, Munster, Germany
    Allergy 65:1430-7. 2010
  7. ncbi Staphylococcus aureus biofilms: Nemesis of endoscopic sinus surgery
    Deepti Singhal
    Department of Surgery Otorhinolaryngology Head and Neck Surgery, The Queen Elizabeth Hospital, Adelaide, South Australia, Australia
    Laryngoscope 121:1578-83. 2011
  8. ncbi Pathophysiology of chronic rhinosinusitis with nasal polyp
    Joy Hsu
    Division of Allergy Immunology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA
    Am J Rhinol Allergy 25:285-90. 2011
  9. ncbi Rhinosinusitis: establishing definitions for clinical research and patient care
    Eli O Meltzer
    Department of Pediatrics, Allergy and Asthma Medical Group and Research Center, 9610 Granite Ridge Drive, Suite B, San Diego, CA 92123, USA
    J Allergy Clin Immunol 114:155-212. 2004
  10. ncbi Differentiation of chronic sinus diseases by measurement of inflammatory mediators
    T Van Zele
    Upper Airway Research Laboratory URL, Department of Oto Rhino Laryngology, Ghent University Hospital, Ghent
    Allergy 61:1280-9. 2006

Detail Information

Publications290 found, 100 shown here

  1. ncbi Clinical practice guideline: adult sinusitis
    Richard M Rosenfeld
    Department of Otolaryngology, SUNY Downstate Medical Center and Long Island College Hospital, Brooklyn, NY 11201 5514, USA
    Otolaryngol Head Neck Surg 137:S1-31. 2007
    This guideline provides evidence-based recommendations on managing sinusitis, defined as symptomatic inflammation of the paranasal sinuses...
  2. ncbi EPOS 2012: European position paper on rhinosinusitis and nasal polyps 2012. A summary for otorhinolaryngologists
    Wytske J Fokkens
    Department of Otorhinolaryngology, Academic Medical Center, Amsterdam, The Netherlands
    Rhinology 50:1-12. 2012
    ..This executive summary for otorhinolaryngologists focuses on the most important changes and issues for otorhinolaryngologists. The full document can be downloaded for free on the website of this journal: http://www.rhinologyjournal.com...
  3. ncbi Microbiology of sinusitis
    Itzhak Brook
    Georgetown University School of Medicine, Washington DC, USA
    Proc Am Thorac Soc 8:90-100. 2011
    ..Rhinoviruses, influenza viruses, and parainfluenza viruses are the most common causes of sinusitis. The most common bacteria isolated from pediatric and adult patients with community-acquired acute purulent ..
  4. ncbi Chronic rhinosinusitis in Europe--an underestimated disease. A GA²LEN study
    D Hastan
    Department of Otorhinolaryngology, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands
    Allergy 66:1216-23. 2011
    ....
  5. ncbi Role of staphylococcal superantigens in upper airway disease
    Claus Bachert
    Upper Airway Research Laboratory, Ear Nose and Throat Department, University Hospital Ghent, Ghent, Belgium
    Curr Opin Allergy Clin Immunol 8:34-8. 2008
    ..Enterotoxins derived from Staphylococcus aureus have been implicated in the pathophysiology of nasal polyps as disease-modifying factors; recent findings using therapeutic proof-of-concept approaches support this hypothesis...
  6. ncbi Staphylococcus aureus invades the epithelium in nasal polyposis and induces IL-6 in nasal epithelial cells in vitro
    F Sachse
    Department of Otorhinolaryngology, University Hospital Munster, Munster, Germany
    Allergy 65:1430-7. 2010
    ..Here, we demonstrate S. aureus detection in the mucosa of CRSwNP. In addition, intracellular residency of S. aureus in nasal polyp epithelial cells (NPECs) and its capability to induce TH-2 cytokines were analyzed in vitro...
  7. ncbi Staphylococcus aureus biofilms: Nemesis of endoscopic sinus surgery
    Deepti Singhal
    Department of Surgery Otorhinolaryngology Head and Neck Surgery, The Queen Elizabeth Hospital, Adelaide, South Australia, Australia
    Laryngoscope 121:1578-83. 2011
    ..We aimed to prospectively investigate the effects of Staphylococcus aureus, Pseudomonas aeruginosa, Haemophilus influenzae, and fungal biofilms on outcomes following endoscopic sinus surgery (ESS)...
  8. ncbi Pathophysiology of chronic rhinosinusitis with nasal polyp
    Joy Hsu
    Division of Allergy Immunology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA
    Am J Rhinol Allergy 25:285-90. 2011
    ..Chronic rhinosinusitis (CRS) is a common inflammatory condition of the paranasal sinuses and nasal passages. CRS with nasal polyp (CRSwNP) is a subtype of CRS, and the pathogenesis of CRSwNP remains largely unclear...
  9. ncbi Rhinosinusitis: establishing definitions for clinical research and patient care
    Eli O Meltzer
    Department of Pediatrics, Allergy and Asthma Medical Group and Research Center, 9610 Granite Ridge Drive, Suite B, San Diego, CA 92123, USA
    J Allergy Clin Immunol 114:155-212. 2004
  10. ncbi Differentiation of chronic sinus diseases by measurement of inflammatory mediators
    T Van Zele
    Upper Airway Research Laboratory URL, Department of Oto Rhino Laryngology, Ghent University Hospital, Ghent
    Allergy 61:1280-9. 2006
    ..Studying inflammatory cells and mediators in clearly defined disease subgroups may lead to a better differentiation of chronic sinus diseases...
  11. ncbi Adult chronic rhinosinusitis: definitions, diagnosis, epidemiology, and pathophysiology
    Michael S Benninger
    Department of Otolaryngology Head and Neck Surgery, Henry Ford Hospital, Detroit, MI 48202, USA
    Otolaryngol Head Neck Surg 129:S1-32. 2003
  12. ncbi Different types of T-effector cells orchestrate mucosal inflammation in chronic sinus disease
    Nan Zhang
    Upper Airway Research Laboratory URL, Department of Oto Rhino Laryngology, Ghent University Hospital, Ghent, Belgium
    J Allergy Clin Immunol 122:961-8. 2008
    ..Chronic rhinosinusitis with nasal polyps (CRSwNP) is characterized by the accumulation of inflammatory cells; however, an eosinophil predominance is seen in white (Belgian), but not Asian (south Chinese), patients with polyps...
  13. ncbi Adaptive immune responses in Staphylococcus aureus biofilm-associated chronic rhinosinusitis
    A Foreman
    Department of Surgery Otorhinolaryngology, Head and Neck Surgery, University of Adelaide, Australia
    Allergy 66:1449-56. 2011
    ..aureus biofilm-associated CRS and the relative contributions of staphylococcal superantigens and S. aureus biofilms in the inflammatory make-up of this disease...
  14. ncbi Pathogenesis of chronic rhinosinusitis: inflammation
    Koen Van Crombruggen
    Upper Airway Research Laboratory, Department of Otorhinolaryngology, Ghent University Hospital, Ghent, Belgium
    J Allergy Clin Immunol 128:728-32. 2011
    ..This review focuses on recent evidence that sheds new light on our current knowledge regarding the inflammatory process of CRS to further unravel its pathogenesis...
  15. ncbi Chronic rhinosinusitis: epidemiology and medical management
    Daniel L Hamilos
    Massachusetts General Hospital, Division of Rheumatology, Allergy and Immunology, Boston, MA 02114, USA
    J Allergy Clin Immunol 128:693-707; quiz 708-9. 2011
    ..The various modalities of medical treatment are reviewed in the context of recent consensus documents and the author's personal experience...
  16. ncbi Expression of TGF, matrix metalloproteinases, and tissue inhibitors in Chinese chronic rhinosinusitis
    Xiaoyuan Li
    Department of Oto Rhino Laryngology, West China Medical School, Sichuan University, Chengdu, Sichuan, 610041, China
    J Allergy Clin Immunol 125:1061-8. 2010
    ..To date there is no information on the expression of mediators associated with tissue remodeling in Asian patients with chronic rhinitis with (CRSwNP) or without (CRSsNP) nasal polyps...
  17. ncbi Genetics and phenotyping in chronic sinusitis
    Spencer C Payne
    Asthma and Allergic Disease Center, Department of Medicine, University of Virginia Health System, Charlottesville, VA 22903, USA
    J Allergy Clin Immunol 128:710-20; quiz 721-2. 2011
    Chronic sinusitis with nasal polyposis historically has been treated as a single monolithic clinical disorder...
  18. ncbi IDSA clinical practice guideline for acute bacterial rhinosinusitis in children and adults
    Anthony W Chow
    Division of Infectious Diseases, Department of Medicine, University of British Columbia, Vancouver, Canada
    Clin Infect Dis 54:e72-e112. 2012
    ..Recommendations for diagnosis, laboratory investigation, and empiric antimicrobial and adjunctive therapy were developed...
  19. ncbi Biofilm formation by Staphylococcus aureus and Pseudomonas aeruginosa is associated with an unfavorable evolution after surgery for chronic sinusitis and nasal polyposis
    Zohra Bendouah
    Department of Otolaryngology Head and Neck Surgery, Universite de Montreal, Canada
    Otolaryngol Head Neck Surg 134:991-6. 2006
    ..To determine whether biofilm-forming capacity of bacteria demonstrated in chronic rhinosinusitis (CRS) has an impact on persistence of the disease following endoscopic sinus surgery (ESS)...
  20. ncbi Nasal lavage with mupirocin for the treatment of surgically recalcitrant chronic rhinosinusitis
    Brent Uren
    Department of Surgery Otolaryngology, University of Adelaide, Woodville, Australia
    Laryngoscope 118:1677-80. 2008
    ..To examine the efficacy and tolerability of topical mupirocin for the management of surgically recalcitrant chronic rhinosinusitis (CRS) associated with Staphylococcus aureus infection...
  21. ncbi The expression of fibrinolytic components in chronic paranasal sinus disease
    Takayuki Sejima
    Upper Airway Research Laboratory, Department of Otorhinolaryngology, Ghent University Hospital, Ghent, Belgium
    Am J Rhinol Allergy 25:1-6. 2011
    ..To clarify the relationship between these components and the pathology of CRS, we analyzed fibrinolytic components in sinonasal mucosa of CRS...
  22. ncbi Infections after endoscopic polypectomy using nasal steroids
    Daniel Bross-Soriano
    Department of Otolaryngology, Manuel Gea Gonzalez General Hospital, Mexico City, Mexico
    Otolaryngol Head Neck Surg 130:319-22. 2004
    ..An increase in infection has occurred with the use of fluticasone propionate after endoscopic polypectomy...
  23. ncbi Sinonasal inhalation of dornase alfa in CF: A double-blind placebo-controlled cross-over pilot trial
    Jochen G Mainz
    Department of Paediatrics, Cystic Fibrosis Centre, University Hospital of Jena, Kochstrasse 2, 07740 Jena, Germany
    Auris Nasus Larynx 38:220-7. 2011
    ..This DBPC pilot-trial applying dornase alfa aims to evaluate outcome parameters and sample sizes for a subsequent efficacy trial...
  24. ncbi Treatment of recurrent chronic hyperplastic sinusitis with nasal polyposis
    Desiderio Passali
    ENT Department, University of Siena Medical School, Siena, Italy
    Arch Otolaryngol Head Neck Surg 129:656-9. 2003
    ..channel at the basolateral surface of the respiratory epithelial cell, vs no therapeutic intervention vs intranasal mometasone furoate, a corticosteroid, in preventing relapses of chronic hyperplastic sinusitis with nasal polyposis.
  25. ncbi A prospective single-blind randomized controlled study of use of hyaluronic acid nasal packs in patients after endoscopic sinus surgery
    Peter John Wormald
    Department of Surgery Otolaryngology, Head and Neck Surgery, The University of Adelaide and Flinders University, Adelaide, South Australia, Australia
    Am J Rhinol 20:7-10. 2006
    ..The aim of this study was to determine whether there was any benefit or detrimental consequences of placing a hyaluronic acid pack (Merogel) into the middle meatus after endoscopic sinus surgery (ESS)...
  26. ncbi Characterization of bacterial and fungal biofilms in chronic rhinosinusitis
    Andrew Foreman
    Department of Surgery Otorhinolaryngology, Head and Neck Surgery, University of Adelaide, Adelaide, Australia
    Am J Rhinol Allergy 23:556-61. 2009
    ..Less is known about the species constituting these biofilms. This study developed a fluorescence in situ hybridization (FISH) protocol for characterization of bacterial and fungal biofilms in CRS...
  27. pmc Extensive surgical and comprehensive postoperative medical management for cystic fibrosis chronic rhinosinusitis
    Frank W Virgin
    Division of Otolaryngology, Department of Surgery, University of Alabama at Birmingham, 1530 3rd Avenue S, Birmingham, AL 35294, USA
    Am J Rhinol Allergy 26:70-5. 2012
    ..However, clinical outcomes of aggressive sinus surgery with regimented postoperative medical treatment have not been systematically evaluated...
  28. pmc Microbiome complexity and Staphylococcus aureus in chronic rhinosinusitis
    Leah M Feazel
    Division of Infectious Diseases, University of Colorado School of Medicine, Aurora, Colorado, USA
    Laryngoscope 122:467-72. 2012
    ....
  29. ncbi Postoperative care for Samter's triad patients undergoing endoscopic sinus surgery: a double-blinded, randomized controlled trial
    Brian W Rotenberg
    Department of Otolaryngology Head and Neck Surgery, Schulich School of Medicine and Dentistry, The University of Western Ontario, London, Ontario, Canada
    Laryngoscope 121:2702-5. 2011
    ..The purpose of this study was to compare three different standardized medication regimens prescribed to these patients after ESS...
  30. ncbi Staphylococcal exotoxins and nasal polyposis: analysis of systemic and local responses
    Anju Tripathi
    Division of Allergy Immunology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA
    Am J Rhinol 19:327-33. 2005
    ..The aim of this study was to correlate SAg activity as inferred by staphylococcal-specific T-cell receptor (TCR) V-beta expansion in the polyp and blood of CRS/NP patients with staphylococcal-specific anti-IgE antibodies in the serum...
  31. ncbi Different biofilms, different disease? A clinical outcomes study
    Andrew Foreman
    Department of Surgery Otorhinolaryngology, Head and Neck Surgery, University of Adelaide and Flinders University, Adelaide, Australia
    Laryngoscope 120:1701-6. 2010
    ..Recent advances have allowed the species within the biofilms of CRS patients to be clearly characterized. This study investigates whether different biofilm species have different disease outcomes...
  32. ncbi Incremental health care utilization and expenditures for chronic rhinosinusitis in the United States
    Neil Bhattacharyya
    Division of Otolaryngology, Brigham and Women s Hospital, and the Department of Otology and Laryngology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Ann Otol Rhinol Laryngol 120:423-7. 2011
    ..I determined incremental increases in health care expenditures and utilization associated with chronic rhinosinusitis (CRS)...
  33. ncbi Alternatively activated macrophages and impaired phagocytosis of S. aureus in chronic rhinosinusitis
    O Krysko
    The Upper Airway Research Laboratory, Department of Oto Rhino Laryngology, Ghent University Hospital, Ghent, Belgium
    Allergy 66:396-403. 2011
    ..Colonization by Staphylococcus aureus is increased in CRSwNP. We aimed to determine macrophage phenotypes in nasal mucosa of CRSwNP and CRSsNP and to examine phagocytosis of S. aureus in these pathologies...
  34. ncbi Contemporary assessment of the disease burden of sinusitis
    Neil Bhattacharyya
    Division of Otolaryngology, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Am J Rhinol Allergy 23:392-5. 2009
    The objective of this study was to determine the disease burden of sinusitis relative to other medical conditions.
  35. ncbi Microbiology of sinusitis: does allergy or endoscopic sinus surgery affect the microbiologic flora?
    Daniel A Larson
    Department of Otolaryngology Head and Neck Surgery, Eastern Virginia Medical School, Norfolk, Virginia 23507, USA
    Curr Opin Otolaryngol Head Neck Surg 19:199-203. 2011
    ..To explore the role of bacteria in the pathogenesis of chronic rhinosinusitis and how the presence of allergies or endoscopic sinus surgery may affect the bacterial flora...
  36. ncbi Current thinking on the relationship between rhinosinusitis and asthma
    Alpa Laheri Jani
    Division of Allergy and Clinical Immunology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    J Asthma 42:1-7. 2005
    ....
  37. ncbi Lack of efficacy of long-term, low-dose azithromycin in chronic rhinosinusitis: a randomized controlled trial
    W J Videler
    Department of Otorhinolaryngology, Academic Medical Centre, Amsterdam, The Netherlands
    Allergy 66:1457-68. 2011
    ..The MACS (Macrolides in chronic rhinosinusitis) study is a randomized placebo-controlled trial evaluating the efficacy of azithromycin (AZM) in CRS...
  38. ncbi The impact of biofilms on outcomes after endoscopic sinus surgery
    Deepti Singhal
    Department of Surgery Otorhinolaryngology, Head and Neck Surgery, The Queen Elizabeth Hospital, 28 Woodville Road, Woodville South, South Australia 5011, Australia
    Am J Rhinol Allergy 24:169-74. 2010
    ..The aim of this study was to investigate the effect of biofilms on postsurgical outcomes after ESS...
  39. pmc Fungal rhinosinusitis: a categorization and definitional schema addressing current controversies
    Arunaloke Chakrabarti
    Department of Medical Microbiology, Postgraduate Institute of Medical Education and Research, Chandigarh, India
    Laryngoscope 119:1809-18. 2009
    Fungal (rhino-) sinusitis encompasses a wide spectrum of immune and pathological responses, including invasive, chronic, granulomatous, and allergic disease...
  40. ncbi TGF-beta signaling and collagen deposition in chronic rhinosinusitis
    Nicholas Van Bruaene
    Upper Airway Research Laboratory, Department of Oto Rhino Laryngology, Ghent University Hospital, Ghent University, Ghent, Belgium
    J Allergy Clin Immunol 124:253-9, 259.e1-2. 2009
    ..Chronic rhinosinusitis is an inflammatory disease with distinct cytokine and remodeling patterns...
  41. ncbi The epidemiology of chronic rhinosinusitis in Canadians
    Yue Chen
    Department of Epidemiology and Community Medicine, Faculty of Medicine, University of Ottawa, 451 Smyth Road, Ottawa, Ontario, Canada K1H 8M5
    Laryngoscope 113:1199-205. 2003
    ..To study the prevalence of chronic rhinosinusitis and its risk factors among Canadians...
  42. ncbi Effects of endoscopic sinus surgery and delivery device on cadaver sinus irrigation
    Richard J Harvey
    Department of Otolaryngology Head and Neck Surgery, Medical University of South Carolina, Charleston, SC, USA
    Otolaryngol Head Neck Surg 139:137-42. 2008
    ..Assess paranasal sinus distribution of topical solutions following endoscopic sinus surgery (ESS) using various delivery devices...
  43. ncbi Treatment of chronic rhinosinusitis with nasal polyposis with oral steroids followed by topical steroids: a randomized trial
    Sriram Vaidyanathan
    Ninewells Hospital, University of Dundee, United Kingdom
    Ann Intern Med 154:293-302. 2011
    ..Chronic rhinosinusitis (CRS) with nasal polyposis is common. The long-term efficacy and safety of approaches to medical management are not well-known...
  44. ncbi The effect of bacterial biofilms on post-sinus surgical outcomes
    Alkis J Psaltis
    Department of Surgery Otorhinolayrngology Head and Neck Surgery, The University of Adelaide, Adelaide, South Australia
    Am J Rhinol 22:1-6. 2008
    ..This study was performed to evaluate the role that bacterial biofilms have on post-sinus surgical outcomes...
  45. ncbi Baby shampoo nasal irrigations for the symptomatic post-functional endoscopic sinus surgery patient
    Alexander G Chiu
    Division of Rhinology, Department of Otorhinolaryngology Head and Neck Surgery, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Am J Rhinol 22:34-7. 2008
    ....
  46. pmc Bacterial sinusitis and otitis media following influenza virus infection in ferrets
    Ville T Peltola
    Department of Infectious Diseases, St Jude Children s Research Hospital, 332 N Lauderdale St, Memphis, TN 38105 2794, USA
    Infect Immun 74:2562-7. 2006
    Streptococcus pneumoniae is the leading cause of otitis media, sinusitis, and pneumonia. Many of these infections result from antecedent influenza virus infections...
  47. ncbi Topical antimicrobials in the management of chronic rhinosinusitis: a systematic review
    Mingyann Lim
    Department of Otolaryngology, Singapore General Hospital, Singapore
    Am J Rhinol 22:381-9. 2008
    ..The purpose of this study was to identify evidence for the use of topical antibiotics in the treatment of CRS and exacerbations of CRS...
  48. ncbi EP3OS 2007: European position paper on rhinosinusitis and nasal polyps 2007. A summary for otorhinolaryngologists
    Wytske Fokkens
    Department of Otorhinolaryngology, Amsterdam Medical Centre, The Netherlands
    Rhinology 45:97-101. 2007
  49. ncbi Evidence of an intracellular reservoir in the nasal mucosa of patients with recurrent Staphylococcus aureus rhinosinusitis
    Sophie Clement
    Department of Pathology and Immunology, University of Geneva, Switzerland
    J Infect Dis 192:1023-8. 2005
    ..Intracellular residence may provide a sanctuary for pathogenic bacteria by protecting them from host defense mechanisms and antibiotic treatment during acute, recurrent S. aureus rhinosinusitis...
  50. ncbi The diagnosis and management of sinusitis: a practice parameter update
    Raymond G Slavin
    J Allergy Clin Immunol 116:S13-47. 2005
  51. ncbi Prevalence of biofilm-forming bacteria in chronic rhinosinusitis
    Anthony A Prince
    The University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Am J Rhinol 22:239-45. 2008
    ..We sought to determine the prevalence of biofilm-forming cultures obtained from patients with CRS and clinical factors that may contribute to biofilm formation...
  52. ncbi Fluticasone propionate aqueous nasal spray does not influence the recurrence rate of chronic rhinosinusitis and nasal polyps 1 year after functional endoscopic sinus surgery
    M D Dijkstra
    Department of Otorhinolaryngology, Erasmus MC, Rotterdam, The Netherlands
    Clin Exp Allergy 34:1395-400. 2004
    ..Their efficacy after functional endoscopic sinus surgery (FESS) has not been fully established by placebo-controlled trials...
  53. ncbi Antimicrobial treatment guidelines for acute bacterial rhinosinusitis
    Jack B Anon
    University of Pittsburgh, School of Medicine, USA
    Otolaryngol Head Neck Surg 130:1-45. 2004
  54. ncbi Oral steroids and doxycycline: two different approaches to treat nasal polyps
    Thibaut Van Zele
    Department of Otorhinolaryngology, University Hospital Ghent, 9000 Ghent, Belgium
    J Allergy Clin Immunol 125:1069-1076.e4. 2010
    ..There is little scientific evidence to support the current practice of using oral glucocorticosteroids and antibiotics to treat patients with chronic rhinosinusitis and nasal polyps...
  55. ncbi Functional endoscopic sinus surgery: 5 year follow up and results of a prospective, randomised, stratified, double-blind, placebo controlled study of postoperative fluticasone propionate aqueous nasal spray
    Julian M Rowe-Jones
    Otorhinolaryngology Head and Neck Facial Plastic Surgery Department, Royal Surrey County Hospital, Guildford, United Kingdom
    Rhinology 43:2-10. 2005
    ..Significantly more prednisolone rescue medication courses were prescribed in the placebo group. Of the 12 patients who failed the study, 10 were in the placebo group. This difference nearly achieved significance...
  56. ncbi Mode of action of long-term low-dose macrolide therapy for chronic sinusitis in the light of neutrophil recruitment
    Hideaki Suzuki
    Department of Otolaryngology, Sendai National Hospital, Sendai, Japan
    Curr Drug Targets Inflamm Allergy 1:117-26. 2002
    Chronic sinusitis is a common inflammatory upper respiratory tract disease. One of the prominent features of this disease is persistent purulent effusion containing numerous emigrated neutrophils in the paranasal sinuses...
  57. ncbi The incidence of concha bullosa and its relationship to nasal septal deviation and paranasal sinus disease
    Jamie S Stallman
    Department of Radiology the Mount Sinai School of Medicine of New York University, New York, NY 10029, USA
    AJNR Am J Neuroradiol 25:1613-8. 2004
    ..However, to our knowledge, no study has evaluated concha bullosa in relation to nasal septal deviation. We sought to analyze the incidence of concha bullosa and any correlation with nasal septal deviation and paranasal sinus disease...
  58. ncbi Chronic sinusitis with nasal polyps: staphylococcal exotoxin immunoglobulin E and cellular inflammation
    David B Conley
    Department of Otolaryngology Head and Neck Surgery, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
    Am J Rhinol 18:273-8. 2004
    The etiology of chronic sinusitis with nasal polyposis (CS/NP) remains enigmatic. Frequently, Staphylococcus aureus is present in the nose of CS/NP patients, although the significance is unclear...
  59. pmc Immunoglobulins and complement factor C4 in adult rhinosinusitis
    M Seppanen
    Division of Infectious Diseases, Department of Medicine, Helsinki University Central Hospital, Hospital District of Helsinki and Uusimaa, PO Box 348, FI 00029 HUS, Helsinki, Finland
    Clin Exp Immunol 145:219-27. 2006
    ..Multiple clinical and immunological parameters may need to be evaluated when searching for prognostic variables...
  60. ncbi Temporal bone pneumatization and its relationship to paranasal sinus development in cystic fibrosis
    Clarice M Seifert
    Department of Otolaryngology Head and Neck Surgery, Medical University of South Carolina, Charleston, South Carolina, USA
    Rhinology 48:233-8. 2010
    ..It is often assumed that mucosal disease of the paranasal sinuses will negatively influence development and pneumotization of the paranasal sinuses and temporal bone system...
  61. ncbi Evidence of dysregulated cytokine production by sinus lavage and peripheral blood mononuclear cells in patients with treatment-resistant chronic rhinosinusitis
    H Jyonouchi
    Department of Pediatrics, School of Medicine, University of Minnesota, MMC 610 FUMC, 420 Delaware St SE, Minneapolis, MN 55455, USA
    Arch Otolaryngol Head Neck Surg 127:1488-94. 2001
    ..Treatment-resistant chronic rhinosinusitis (CRS) imposes a clinical challenge. Its pathogenesis may be associated with dysregulated immune/inflammatory responses in the sinus...
  62. ncbi Rhinosinusitis: Establishing definitions for clinical research and patient care
    Eli O Meltzer
    Allergy and Asthma Medical Group and Research Center, Department of Pediatrics, University of California, San Diego 92123, USA
    Otolaryngol Head Neck Surg 131:S1-62. 2004
  63. ncbi The Sino-Nasal Outcome Test (SNOT): can we make it more clinically meaningful?
    John Patrick Browne
    Clinical Effectiveness Unit, Royal College of Surgeons of England, London, UK
    Otolaryngol Head Neck Surg 136:736-41. 2007
    ..To test whether subscales should be used when analyzing the Sino-Nasal Outcome Test (SNOT)...
  64. pmc Characterization of specific antibody deficiency in adults with medically refractory chronic rhinosinusitis
    Tara F Carr
    Division of Allergy Immunology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA
    Am J Rhinol Allergy 25:241-4. 2011
    ..There is limited literature assessing specific antibody deficiency in chronic rhinosinusitis (CRS). This study evaluated the role of specific antibody deficiency in patients with CRS who have failed medical therapy...
  65. pmc Use of an electronic health record clinical decision support tool to improve antibiotic prescribing for acute respiratory infections: the ABX-TRIP study
    Cara B Litvin
    Division of General Internal Medicine and Geriatrics, Department of Medicine, Medical University of South Carolina, 135 Rutledge Ave, Charleston, SC 29425, USA
    J Gen Intern Med 28:810-6. 2013
    ..Antibiotics are often inappropriately prescribed for acute respiratory infections (ARIs)...
  66. ncbi Comparison of once- versus twice-daily use of beclomethasone dipropionate aqueous nasal spray in the treatment of allergic and non-allergic chronic rhinosinusitis
    R Giger
    Department of Otorhinolaryngology Head and Neck Surgery, Geneva University Hospital, Geneva, Switzerland
    Eur Arch Otorhinolaryngol 260:135-40. 2003
    ..The once-daily BDP dosing (400 micro g/day) therefore has a similar efficacy and safety profile as the same daily dose given in a twice-daily regimen...
  67. ncbi Detection of fungi in the sinus mucosa using polymerase chain reaction
    Arvin K Rao
    Department of Otolaryngology Head and Neck Surgery, West Virginia University School of Medicine, Morgantown, West Virginia 26506 9200, USA
    Otolaryngol Head Neck Surg 134:581-5. 2006
    ..To compare the presence of fungi in the sinus mucosa of patients with and without chronic rhinosinusitis...
  68. ncbi The assessment of topical nasal drug distribution
    R Aggarwal
    Department of Otolaryngology, Head and Neck Surgery, Manchester Royal Infirmary, Manchester, UK
    Clin Otolaryngol Allied Sci 29:201-5. 2004
    ..This study reviews intranasal drug delivery assessment methods, the present knowledge and explores future directions for research...
  69. pmc Sinus hypoplasia precedes sinus infection in a porcine model of cystic fibrosis
    Eugene H Chang
    Department of Otolaryngology Head and Neck Surgery, Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA
    Laryngoscope 122:1898-905. 2012
    Chronic sinusitis is nearly universal in humans with cystic fibrosis (CF) and is accompanied by sinus hypoplasia (small sinuses)...
  70. ncbi Association of IL1A, IL1B, and TNF gene polymorphisms with chronic rhinosinusitis with and without nasal polyposis: A replication study
    Leandra Mfuna Endam
    Department of Otolaryngology, Centre de Recherche du Centre Hospitalier de l Université de Montréal Hôtel Dieu, Canada
    Arch Otolaryngol Head Neck Surg 136:187-92. 2010
    ....
  71. ncbi Staphylococcus aureus colonization and IgE antibody formation to enterotoxins is increased in nasal polyposis
    Thibaut Van Zele
    J Allergy Clin Immunol 114:981-3. 2004
  72. ncbi Biofilms in chronic rhinosinusitis with nasal polyps
    Thiago Freire Pinto Bezerra
    Department of Otorhinolaryngology and Ophthalmology, School of Medicine, University of Sao Paulo, Sao Paulo, SP, Brazil
    Otolaryngol Head Neck Surg 144:612-6. 2011
    1) Evaluate the presence of biofilms in patients with chronic sinusitis with nasal polyps (CRSwNP) and (2) investigate the association of biofilm presence and CRSwNP.
  73. ncbi Effect of carboxymethylcellulose nasal packing on wound healing after functional endoscopic sinus surgery
    Konrad G Kastl
    Department of Otorhinolaryngology, University Hospital Ulm, Ulm, Germany
    Am J Rhinol Allergy 23:80-4. 2009
    ..The purpose of this study was to investigate the effect of carboxy-methylated cellulose (CMC) nasal packing on wound healing after FESS compared with no nasal packing...
  74. ncbi Association of chronic rhinosinusitis with nasal polyps and asthma: clinical and radiological features, allergy and inflammation markers
    Jūrate Staikūniene
    Department of Pulmonology and Immunology, Kaunas University of Medicine, Eiveniu 2, 50009 Kaunas, Lithuania
    Medicina (Kaunas) 44:257-65. 2008
    ....
  75. ncbi Adenoids during childhood: the facts
    G L Marseglia
    Department of Pediatrics, University of Pavia Foundation IRCCS Policlinico San Matteo, Italy
    Int J Immunopathol Pharmacol 24:1-5. 2011
    ..biofilms that could justify the concomitant presence of recurrent episodes of otitis media, chronic and occult sinusitis in children...
  76. ncbi Chronic and recurrent cough, sinusitis and asthma. Much ado about nothing
    E Barbi
    Clinica Pediatrica, IRCCS Burlo Garofolo, Trieste, Italy
    Pediatr Allergy Immunol 18:22-4. 2007
    ..The relation between sinusitis, asthma and isolated cough is possibly overemphasized...
  77. ncbi Does nasal irrigation enter paranasal sinuses in chronic rhinosinusitis?
    Kornkiat Snidvongs
    Department of Otolaryngology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand
    Am J Rhinol 22:483-6. 2008
    ..This study was performed to (1) assess the ability of a nasal douche and spray to deliver a solution into the paranasal sinuses in chronic rhinosinusitis and (2) compare the performance of the two techniques...
  78. ncbi Alterations in gene expression of complement components in chronic rhinosinusitis
    Rodney J Schlosser
    Department of Otolaryngology Head and Neck Surgery, Medical University of South Carolina, Charleston, South Carolina, USA
    Am J Rhinol Allergy 24:21-5. 2010
    ....
  79. ncbi Protein microarray analysis of nasal polyps from aspirin-sensitive and aspirin-tolerant patients with chronic rhinosinusitis
    Kelly A Zander
    Department of Otolaryngology Head and Neck Surgery, University of Colorado Denver, Denver, Colorado, USA
    Am J Rhinol Allergy 23:268-72. 2009
    ....
  80. ncbi Allergic mucin with and without fungus: a comparative clinicopathologic analysis
    J F Lara
    Department of Pathology, Saint Barnabas Medical Center, 94 Old Short Hills Rd, Livingston, NJ 07039, USA
    Arch Pathol Lab Med 125:1442-7. 2001
    ..Allergic mucin, a lamellated collection of inspissated inflammatory debris, has been a hallmark of allergic fungal sinusitis. While its identification is a clue for pathologists to search for fungi, and directs clinicians toward specific ..
  81. ncbi Are lower airway or throat cultures predictive of sinus bacteriology in cystic fibrosis?
    Marianne S Muhlebach
    Department of Pediatrics, University of North Carolina, 27599 7220, USA
    Pediatr Pulmonol 41:445-51. 2006
    The choice of antibiotics for sinusitis in children with cystic fibrosis (CF) is empirical or based on lower airway cultures, because sinus cultures are difficult to obtain...
  82. ncbi [Sinus radiography and low-dose CT in the diagnosis of acute sinusitis. ]
    Trond Hagtvedt
    Tidsskr Nor Laegeforen 123:3362-4. 2003
    ..47 patients referred for acute sinusitis were examined with plain film radiography, low-dose and standard-dose CT on the same day...
  83. ncbi Allergic rhinitis and sinusitis in asthma: differential effects on symptoms and pulmonary function
    Anne E Dixon
    Pulmonary and Critical Care Medicine, University of Vermont, Burlington, 05401, USA
    Chest 130:429-35. 2006
    Allergic rhinitis and sinusitis are frequently associated with asthma...
  84. ncbi Nasal endoscopy in asthmatic children: assessment of rhinosinusitis and adenoiditis incidence, correlations with cytology and microbiology
    M A Tosca
    Allergy and Respiratory Diseases, Department of Internal Medicine, University of Genoa and Head Neck Department, San Martino Hospital, Genoa, Italy
    Clin Exp Allergy 31:609-15. 2001
    BACKGROUND: Upper respiratory airway diseases may induce a worsening of asthma. Sinusitis represents one of the most common chronic diseases...
  85. pmc Rhinosinusitis diagnosis and management for the clinician: a synopsis of recent consensus guidelines
    Eli O Meltzer
    Allergy and Asthma Medical Group and Research Center, 9610 Granite Ridge Dr, Ste B, San Diego, CA 92123, USA
    Mayo Clin Proc 86:427-43. 2011
    ..Rhinosinusitis Initiative, the Joint Task Force on Practice Parameters, the Clinical Practice Guideline: Adult Sinusitis, the European Position Paper on Rhinosinusitis and Nasal Polyps 2007, and the British Society for Allergy and ..
  86. ncbi Nebulized bacitracin/colimycin: a treatment option in recalcitrant chronic rhinosinusitis with Staphylococcus aureus? A double-blind, randomized, placebo-controlled, cross-over pilot study
    W J M Videler
    Dept of Otorhinolaryngology, Academic Medical Center, Amsterdam, The Netherlands
    Rhinology 46:92-8. 2008
    ..surgery there still remains a group of unfortunate patients suffering from exacerbations of recalcitrant chronic sinusitis. We have performed a pilot study in order to determine whether nebulized topical antibiotic therapy improves ..
  87. ncbi A prospective, randomised, placebo-controlled trial of postoperative oral steroid in allergic fungal sinusitis
    V Rupa
    Department of ENT, Christian Medical College and Hospital, Vellore 632004, India
    Eur Arch Otorhinolaryngol 267:233-8. 2010
    ..the effectiveness of postoperative oral steroid in controlling disease in patients with allergic fungal sinusitis (AFS)...
  88. ncbi A double-blind, randomized, placebo-controlled trial of macrolide in the treatment of chronic rhinosinusitis
    Ben Wallwork
    School of Biomolecular and Biomedical Science, Griffith University, and Princess Alexandria Hospital, Brisbane, Australia
    Laryngoscope 116:189-93. 2006
    ..To date, this effect has not been tested in a randomized, placebo-controlled study...
  89. ncbi No evidence for a correlation of glutathione S-tranferase polymorphisms and chronic rhinosinusitis
    K Fruth
    Department of Otolaryngology, Head and Neck Surgery, University Medical Center of the Johannes Gutenberg University Mainz, Germany
    Rhinology 49:180-4. 2011
    ..In this study, we analysed the potential association of GST-polymorphisms and chronic rhinosinusitis (CRS)...
  90. pmc Mycobacterium chelonae-abscessus complex associated with sinopulmonary disease, Northeastern USA
    Keith E Simmon
    Associated Regional and University Pathologists Institute for Clinical and Experimental Pathology, Salt Lake City, UT 84108, USA
    Emerg Infect Dis 17:1692-700. 2011
    ..Because most isolates originated in Pennsylvania, we propose the name M. franklinii sp. nov. This investigation underscores the need for accurate identification of Mycobacterium spp. to detect new pathogens implicated in human disease...
  91. ncbi Correlation between symptoms and radiological findings in patients of chronic rhinosinusitis: a modified radiological typing system
    Satish Nair
    Department of ENT, Command Hospital Air Force, Bangalore, Karnataka, India
    Rhinology 47:181-6. 2009
    ..In this study the symptom severity of chronic rhinosinusitis was correlated with the author's modified CT scan score...
  92. ncbi Allergic fungal sinusitis
    Mark S Schubert
    Allergy Asthma Clinic, Ltd, Phoenix, AZ, USA
    Clin Rev Allergy Immunol 30:205-16. 2006
    ..Allergic fungal sinusitis (AFS) is both a type of noninvasive fungal rhinosinusitis and a type of HSD...
  93. ncbi Paranasal fungal sinusitis: contributions of histopathology to diagnosis: a report of 60 cases and literature review
    Jerome B Taxy
    Department of Pathology, Advocate Lutheran General Hospital, Park Ridge, and The University of Chicago, Chicago, IL 60637, USA
    Am J Surg Pathol 30:713-20. 2006
    Sixty cases of fungal sinusitis are presented from 2 institutions, accumulated from 1971 to 2005. Fifty cases were from a large suburban general hospital and 10 from a major university referral center...
  94. ncbi The effect of topical amphotericin B on inflammatory markers in patients with chronic rhinosinusitis: a multicenter randomized controlled study
    Fenna A Ebbens
    Department of Otorhinolaryngology, Head and Neck Surgery, Academic Medical Center, Amsterdam, The Netherlands
    Laryngoscope 119:401-8. 2009
    ..Based on this rationale, the use of topical antifungals (amphotericin B) has been advocated. Studies on its clinical effectiveness are, however, contradictory...
  95. ncbi Potential role of abnormal ion transport in the pathogenesis of chronic sinusitis
    Kenji Dejima
    Department of Otorhinolaryngology, Kyoto Prefectural University of Medicine, Kyoto, Japan
    Arch Otolaryngol Head Neck Surg 132:1352-62. 2006
    To create well-differentiated cultures of normal and chronic sinusitis paranasal sinus epithelial cells and to compare their electrophysiologic properties.
  96. pmc Acquired cilia dysfunction in chronic rhinosinusitis
    David Gudis
    Department of Otorhinolaryngology Head and Neck Surgery, University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104, USA
    Am J Rhinol Allergy 26:1-6. 2012
    ..The complex structure and regulatory mechanisms that dictate the form and function of normal cilia are not entirely understood, but it is clear that ciliary dysfunction results in impaired respiratory defense...
  97. ncbi Do biofilms contribute to the initiation and recalcitrance of chronic rhinosinusitis?
    Andrew Foreman
    Department of Surgery Otorhinolaryngology, Head and Neck Surgery, University of Adelaide and Flinders University, Adelaide, Australia
    Laryngoscope 121:1085-91. 2011
    ....
  98. ncbi Angina masquerading as sinusitis
    A Christoforidou
    Department of Otolaryngology, Derriford Hospital, Plymouth, UK
    J Laryngol Otol 120:961-2. 2006
    ..There are several references in the world literature to angina referred to the teeth and the mandible. This report describes a patient with facial pain which was thought to be of sinus origin and which was relieved by coronary stenting...
  99. ncbi A new low-dose CT examination compared with standard-dose CT in the diagnosis of acute sinusitis
    T Hagtvedt
    Department of Radiology, Rikshospitalet, 0027 Oslo, Norway
    Eur Radiol 13:976-80. 2003
    ..The low-dose CT was prospectively compared with standard-dose CT in patients with suspicion of acute sinusitis. Forty-seven patients were examined with low-dose CT immediately after standard-dose CT...
  100. pmc Bilateral cavernous sinus thrombosis complicating sinusitis
    M Absoud
    Paediatric Registrar, Paediatric Department, Princess Alexandra Hospital, Harlow, Essex CM20 1QX, UK
    J R Soc Med 99:474-6. 2006
  101. ncbi Pre- and postoperative sinus penetration of nasal irrigation
    Alethea Grobler
    Department of Surgery Otolaryngology, Head and Neck Surgery, University of Adelaide and Flinders University, The Queen Elizabeth Hospital, Woodville, South Australia, Australia
    Laryngoscope 118:2078-81. 2008
    ..The aim of this study is to determine a critical ostial size at which douching solution reliably enters the sinus cavities...

Research Grants63

  1. ASTHMA AND ALLERGIC DISEASE CENTER
    Thomas A Platts Mills; Fiscal Year: 2010
    ..Project 3: Impact of chronic hyperplastic eosinophilic sinusitis on asthma: Studies will investigate the hypothesis that the sinus tissue contributes to the systemic ..
  2. Unbiased genome-wide screen to identify genes regulating mucous cell hyperplasia
    Jeffrey A Whitsett; Fiscal Year: 2010
    ..chronic infection and inflammation that contributes to chronic upper respiratory disorders, including chronic sinusitis, allergic rhinitis, middle ear disease, as well as pulmonary disease that contribute to respiratory morbidity ..
  3. Anti-Bacterial Innate Responses Enhance Paramyxovirus Replication
    Griffith D Parks; Fiscal Year: 2010
    ..involving bacteria and paramyxoviruses are a significant factor in human patients with chronic bronchitis, sinusitis and otitis media...
  4. Biology of the HMW1 and HMW2 Adhesins of H. Influenzae
    JOSEPH W ST. GEME; Fiscal Year: 2013
    ..Haemophilus influenzae is a common cause of localized respiratory tract disease, especially otitis media, sinusitis, pneumonia, and exacerbations of chronic lung disease...
  5. Heme, Iron and Oxidative Stress: Regulation of Iron Homeostasis in H. Influenzae
    Robert S Munson; Fiscal Year: 2013
    ..Haemophilus influenzae (NTHi) is a significant human pathogen as it is a major cause of otitis media (OM), sinusitis, exacerbations of chronic obstructive pulmonary disease (COPD) and bronchitis...
  6. Antimicrobial Phototherapy of Antibiotic Resistant Chronic Sinusitis
    MERRILL ABRAHAM BIEL; Fiscal Year: 2011
    ..and determine the optimal methylene blue (MB)/EDTA drug and light parameters necessary for chronic recurrent sinusitis (CRS) treatment in an in vitro novel anatomically accurate human maxillary sinus CRS polymicrobial biofilm model ..
  7. Genetics &Biology of M. catarrhalis LOS in Otitis Media
    Anthony A Campagnari; Fiscal Year: 2013
    Moraxella catarrhalis is a Gram-negative human mucosal pathogen, a significant cause of middle ear infections and sinusitis in infants and children and an important source of exacerbations in adults with lung disease...
  8. Impact of Inflammatory Genes on Glandular Hyperplasia in Children with Sinusitis
    Mary C Rose; Fiscal Year: 2010
    ....
  9. Innate and adaptive immune responses at the respiratory mucosa
    Yasmin Thanavala; Fiscal Year: 2010
    ..between viruses and bacteria are particularly important as they impact on many diseases such as pneumonia, sinusitis, otitis media, COPD and gastroenteritis...
  10. Role of the Indoor Environment on Oxidative Stress Related Sinonasal Inflammation
    Murugappan Ramanathan; Fiscal Year: 2013
    ..His previous research focused on impaired sinonasal epithelial innate immune responses in patients with chronic sinusitis. With the support of this Mentored Career Development Award, Dr...
  11. Prognosis and Determinants of Asthma Morbidity in World Trade Center Rescue and R
    Juan P Wisnivesky; Fiscal Year: 2013
    ..history of asthma in WTC workers;2) evaluate the relationship and impact of upper airway conditions (rhinitis, sinusitis), gatroesophageal reflux disease (GERD), and obstructive sleep apnea (OSA) on asthma morbidity (control and ..
  12. Obstructive Sleep Apnea in WTC Responders: Role of Nasal Pathology
    Jag Sunderram; Fiscal Year: 2013
    ..respiratory symptom when examined in 2004 with 50% of responders continuing to have symptoms of chronic rhino-sinusitis or upper airway disease (UAD) in 2007...
  13. Interplay between LTE4/LTE4 receptors and IFN-y with mast cells and eosinophils i
    Larry C Borish; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): These studies will focus on cellular and immune mechanisms of asthma (and sinusitis) as they pertain to aspirin-exacerbated respiratory disease (AERD)...
  14. Effect of the PPAR Agonist Pioglitazone on Epidermal Barrier in Atopic Dermatitis
    LISA ANN BECK; Fiscal Year: 2012
    ..diseases mediated in part by epithelial barrier defects including inflammatory bowel disease, celiac disease, sinusitis, food allergy and asthma...
  15. TAS::75 0862::TAS
    Martin D Chapman; Fiscal Year: 2010
    Molds cause asthma and allergic respiratory diseases and are associated with other illnesses such as sinusitis, chronic fatigue syndrome, lethargy, or migraines. Mold occurs in damp or water damaged housing...
  16. Evaluation of zinc homeostasis mechanisms in Streptococcus pneumoniae
    FAITH ELLEN JACOBSEN; Fiscal Year: 2010
    Streptococcus pneumoniae is a gram positive organism that is responsible for human diseases such as pneumonia, sinusitis, meningitis and endocarditis...
  17. Sinusitis in Children and the Nasopharyngeal Microbiome
    Ellen Wald; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Acute bacterial sinusitis in children is one of the most common clinical problems presenting to the primary care practitioner. A diagnosis of sinusitis results in over $1...
  18. Role of Memory T Cells in Pathogenesis and Resolution of Inflammatory Diseases
    Richard B Bankert; Fiscal Year: 2010
    Chronic hyperplastic sinusitis with nasal polyposis is characterized by mucosal thickening, goblet cell hyperplasia, subepithelial fibrosis and by the infiltration of inflammatory cells including eosinophils, neutrophils, macrophages, ..
  19. Chlamydia Pneumoniae Antigens of Bilogogical Significance
    Lee Ann Campbell; Fiscal Year: 2012
    ..pneumoniae is an etiological agent of human respiratory disease, causing 5-10% of pneumoniae bronchitis and sinusitis. This pathogen has also been associated with atheroscleroisis and its related clinical manifestations such as ..
  20. Control of airway inflammation and Th2 differentiation by microRNA 21
    Alexander L Dent; Fiscal Year: 2012
    ..with almost 50% of the urban population presenting with atopic diseases including asthma, rhino- conjunctivitis, sinusitis, food allergy, and atopic dermatitis...
  21. Determinants of Medical and Surgical Treatment Outcomes in Chronic Sinusitis
    Timothy L Smith; Fiscal Year: 2013
    ..3 billion, and a significant economic burden in the US. This application examines ways to predict who will benefit from medical vs surgical treatment and evaluate the impact on quality of life. ..
  22. UCSF AsthmaNet Clinical Center
    Stephen C Lazarus; Fiscal Year: 2013
    ..allow examination of differential responses in sub-groups, such as those with symptoms of purulent bronchitis or sinusitis, those with positive culture or PCR for potential bacterial pathogens, and those with evidence of respiratory ..
  23. Investigation of CFTR on sinus and craniofacial development in a CF porcine model
    Eugene H Chang; Fiscal Year: 2013
    ..pig model is the first large animal model for CF, and our preliminary studies show that the CF pig develops sinusitis, and craniofacial changes similar to human CF...
  24. Study of Asthma and Nasal Steriods
    Anne E Dixon; Fiscal Year: 2013
    ..Results from trials completed by ALA-ACRC have identified rhinitis and sinusitis as a significant cause of co-morbidity that affects asthma symptoms and control...
  25. Impact of PCV on disease and colonization among Native American communities
    KATHERINE LOUISE O'BRIEN; Fiscal Year: 2013
    ..like pneumonia, meningitis, and blood stream infections or to less serious, but burdensome, diseases like sinusitis or ear infections...
  26. Role for B-cell mediated olfactory loss in Chronic Sinusitis with Nasal Polyps
    Bruce K Tan; Fiscal Year: 2013
    ..the impact of B-cell mediated inflammation on the pathogenesis and olfactory loss associated with Chronic Sinusitis with Nasal Polyps (CRSwNP)...
  27. Haemophilus Hap-mediated Microcolony Formation
    JOSEPH ST GEME; Fiscal Year: 2002
    ..Haemophilus influenzae is a common cause of localized respiratory tract disease, especially otitis media, sinusitis, bronchitis, and pneumonia...
  28. Development and Validation of NIRS-Based Sinusitis Screening
    JOON YOU; Fiscal Year: 2013
    ..chronic sinusits is associated with over 40 million visits to physicians and health care providers each year. Sinusitis is diagnosed based on clinical history which is difficult to correctly ascertain, and hence misdiagnosis leads ..
  29. Nitric Oxide and Chronic Rhinosinusitis
    Abraham Jacob; Fiscal Year: 2001
    ..While chemiluminescense measurements of NO in exhaled air indicate decreased levels during sinusitis, nasal secretions find increased NO metabolite concentrations...
  30. RELATIONSHIP BETWEEN ALLERGIC RHINITIS AND SINUSITIS
    Fuad Baroody; Fiscal Year: 2003
    Chronic sinusitis was the most frequently reported disease by Americans in the 1993 National Health Interview Survey and is a major contributor to health care costs and decreased productivity...
  31. PRECLINICAL EVAL. OF THERAPIES FOR MICROSPORIDIAL INFECT
    ELIZABETH DIDIER; Fiscal Year: 2000
    ..and other clinical manifestations that may include keratitis, nephritis, pneumonia, hepatitis, peritonitis, and sinusitis. Gastrointestinal infections comprise the vast majority of microspordiosis cases...
  32. Haemophilus Hap-mediated Microcolony Formation
    JOSEPH ST GEME; Fiscal Year: 2007
    ..Haemophilus influenzae is a common cause of localized respiratory tract disease, including otitis media, sinusitis, bronchitis, and pneumonia...
  33. HAEMOPHILUS--RAMIFICATIONS OF PILUS MEDIATED ADHERENCE
    GRAHAM KRASAN; Fiscal Year: 2004
    Haemophilus influenzae is a pathogen that mediates a wide range of human disease including otitis media, sinusitis, and pneumonia often in association with an increased density of nasopharyngeal colonization...
  34. UVA Asthma and Allergic Diseases Center
    Thomas Platts Mills; Fiscal Year: 2005
    ..that many factors contribute to the severity of the disease, including: viral infections, chronic hyperplastic sinusitis, the nature of the immune response to allergens and the biochemistry of the lung response, including the ..
  35. Defining PcsB: Essential Murein Biosynthesis Protein in Pathogenic Pneumococci
    SKYE BARENDT; Fiscal Year: 2009
    ..pathogen mainly of the human respiratory tract, infection of which can result in several diseases, including sinusitis, meningitis, pneumonia, septicemia, and otitis media, making S...
  36. Small Molecule Inhibitors of Cilia
    Wallace Marshall; Fiscal Year: 2007
    ..roles in development and disease, including polycystic kidney disease, hydrocephalus, syndromic obesity, chronic sinusitis, bronchiectasis, and retinal degeneration...
  37. ASTHMA--ALTERNATIVE MEDICINE CENTER
    MERRILL GERSHWIN; Fiscal Year: 2000
    ..In addition, incidence and severity of chronic sinusitis has increased...
  38. ASTHMA AND ALLERGIC DISEASES CENTER
    Thomas Platts Mills; Fiscal Year: 2000
    ..asthma will be investigated to identify' those cases where a search for the causes of eosinophilia and/or sinusitis should be focused...
  39. Polyamine based Therapy of E. bieneusi Infected Mice
    VENUDHAR REDDY; Fiscal Year: 2006
    ..The most common manifestation is gastrointestinal tract infection; however, encephalitis, ocular infection, sinusitis, myositis and disseminated infection are reported...
  40. THE PATHOGENESIS OF CHRONIC SINUSITIS
    James Douglas; Fiscal Year: 2001
    ..the observation that nitric oxide is present in high concentrations in the nose of normal individuals but not in sinusitis patients...
  41. Diagnosing Acute Bacterial Sinusitis in Children and Measuring Treatment Response
    Nader Shaikh; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Sinusitis is the 5th most common diagnosis warranting an antimicrobial prescription in the US...
  42. Healing Chronic Wounds by Controlling Microbial Biofilm
    Philip Stewart; Fiscal Year: 2009
    ..Furthermore, the results of this research may impact the treatment of other biofilm-related diseases, such as osteomyelitis, endocarditis, prostatitis, otitis media, and sinusitis.
  43. Randomized trial of sinus CT for acute sinusitis
    Yoshimi Anzai; Fiscal Year: 2006
    ..a randomized controlled study assessing the impact of sinus CT on the use of antibiotics for patients with acute sinusitis, and to develop and validate clinical prediction rules through the randomized clinical trials...
  44. The NOSES Trial, Nasal irrigation, Oral steroids, Antibiotics and Subgroup target
    Daniel Merenstein; Fiscal Year: 2009
    ..In chronic sinusitis, positive gravity based SNI with a nasal irrigation cup improves symptoms and quality of life (QOL), and many ..
  45. PROCESSES OF CARE AND OUTCOMES IN CHRONIC RHINOSINUSITIS
    KENLEY CHIN; Fiscal Year: 2000
    ..The recent 1999 AHCPR evidence based report on the diagnosis and treatment of sinusitis cited the lack of existing evidence to support specific diagnostic or treatment measures for patients with ..
  46. MOLECULAR AND FUNCTIONAL STUDIES OF H INFLUENZAE PILI
    Janet Gilsdorf; Fiscal Year: 2001
    ..abstract): Haemophilus influenzae (Hi) are significant cause of respiratory tract infections, including sinusitis, otitis media, bronchitis, and pneumonia...
  47. Allergic Rhinitis Augments Bacterial Sinusitis
    Robert Naclerio; Fiscal Year: 2001
    b>Sinusitis is a major health care problem for Americans of all ages...
  48. MUCOSAL DEFENSE BY IGA AGAINST S PNEUMONIAE
    Edward Janoff; Fiscal Year: 2005
    ..Local and systemic manifestations range from asymptomatic colonization, to sinusitis and otitis media, to community-acquired pneumonia, bacteremia, and meningitis, resulting in up to 40,0000 deaths/..
  49. Trial to Reduce Antibiotic Use in A Primary Care PBRN
    David Bates; Fiscal Year: 2004
    ..automatic importation of patients' problems, allergies, and medications; decision-support for the treatment of sinusitis, pharyngitis, and acute bronchitis; printable patient handouts about URIs, self-care, and antibiotics; and ..
  50. Botanicals for Chlamydia pneumonia infections-Revision 1
    Gail Mahady; Fiscal Year: 2005
    ..bacterium, is a significant human pathogen linked with 5-10% of cases of pneumonia, bronchitis, asthma and sinusitis. Infection with CP is wide spread with 50-70% of adults worldwide being seropositive...
  51. EVALUATION OF SAFETY DATA REPORTING IN RANDOMIZED TRIALS
    Joseph Lau; Fiscal Year: 1999
    ..therapy in acute myocardial infarction, treatment of hypertension in the elderly, antibiotic therapy for acute sinusitis, non-steroidal agents for rheumatoid arthritis, treatment for Helicobacter pylori, and selective decontamination ..
  52. Structure of Surface Antigens of S. Pneumoniae
    Debasish Chattopadhyay; Fiscal Year: 2005
    Streptococcus pneumoniae is the main cause of acute otitis media, sinusitis, pneumonia, meningitis and bacteremia. Together, these infections cause well over one million deaths worldwide...
  53. Novel Microarray System for In Vitro Allergen Testing
    Jerzy Olejnik; Fiscal Year: 2004
    Fifty million Americans suffer from allergic diseases including asthma, rhinitis, sinusitis, dermatitis and food allergy...
  54. A Diagnostic Decision Aid for Pediatric Sinusitis
    Dimitri Christakis; Fiscal Year: 2002
    ..g., by diagnosing sinusitis in the setting of cold symptoms) so as to justify their use of antibiotics...
  55. MicroFlex Tools to Improve Sinus Diagnostics & Surgery
    DALE LAWRENCE; Fiscal Year: 2005
    Chronic sinusitis affects approximately 33 million Americans each year, and has become one of the most prevalent chronic diseases...
  56. PEDIATRIC EBM-GETTING EVIDENCE USED AT THE POINT OF CARE
    Robert Davis; Fiscal Year: 2002
    ..reduce frequency and duration of antibiotic therapy for otitis media, (ii) reduce duration of therapy for acute sinusitis, (iii) reduce use of bronchodialators in outpatient treatment of bronchiolitis, and (iv) increase use of ..
  57. SINUSITIS IN HUMAN IMMUNODEFICIENCY VIRUS DISEASE
    David Rosenstreich; Fiscal Year: 1993
    ..b>Sinusitis may be one manifestation of this acquired atopic state. The proposed study has two major purposes...
  58. VACCINE TRIALS USING INDIVIDUAL AND ECOLOGICAL UNITS
    JAMES KOOPMAN; Fiscal Year: 2002
    ..a common cause of otitis media and sinusitis. Specifically, we propose to: (1) determine the power to detect useful effects of trial designs that randomize ..
  59. EPITHELIAL FUNCTION AND DYSFUNCTION IN CHRONIC SINUSITIS
    Alkis Togias; Fiscal Year: 2002
    ..These studies should include important insights into the pathogenesis of chronic rhinosinusitis and may lead to the development of new approaches for the treatment of this major health problem. ..
  60. Asthma Clinical Research Network Center at UCSF
    Homer Boushey; Fiscal Year: 2007
    ..especially in the subgroups currently most often treated, like those with purulent sputum or symptoms of sinusitis. This study will offer an opportunity to examine the validity of a microarray-based approach to detecting ..
  61. Nanostenting Hydrogels for Sinus Surgery
    RICHARD ORLANDI; Fiscal Year: 2004
    ..The results of these Phase I studies will determine the feasibility and the optimal chemical properties of a nanostenting HA gel for human trials. ..
  62. Cytokines on Olfactory Receptor Neuron Function
    Andrew Lane; Fiscal Year: 2006
    ..The project will allow the candidate to pursue his interest in the mechanisms of olfactory loss in chronic sinusitis through a focused, mentored plan to study the effects of inflammatory mediators on olfactory receptor neuron (..