severe acute respiratory syndrome

Summary

Summary: A viral disorder characterized by high FEVER, dry COUGH, shortness of breath (DYSPNEA) or breathing difficulties, and atypical PNEUMONIA. A virus in the genus CORONAVIRUS is the suspected agent.

Top Publications

  1. ncbi Bats are natural reservoirs of SARS-like coronaviruses
    Wendong Li
    Institute of Zoology, Chinese Academy of Sciences CAS, Beijing, China
    Science 310:676-9. 2005
  2. pmc Transmission dynamics and control of severe acute respiratory syndrome
    Marc Lipsitch
    Department of Epidemiology, Harvard School of Public Health, 677 Huntington Avenue, Boston, MA 02115, USA
    Science 300:1966-70. 2003
  3. ncbi Network theory and SARS: predicting outbreak diversity
    Lauren Ancel Meyers
    Section of Integrative Biology and Institute for Cellular and Molecular Biology, University of Texas at Austin, 1 University Station C0930, Austin, TX 78712, USA
    J Theor Biol 232:71-81. 2005
  4. ncbi Severe acute respiratory syndrome
    J S M Peiris
    Department of Microbiology, The University of Hong Kong, University Pathology Building, Queen Mary Hospital, Pokfualm, Hong Kong Special Administrative Region of China
    Nat Med 10:S88-97. 2004
  5. ncbi Identification of a novel coronavirus in patients with severe acute respiratory syndrome
    Christian Drosten
    Bernhard Nocht Institute for Tropical Medicine, National Reference Center for Tropical Infectious Diseases, Hamburg, Germany
    N Engl J Med 348:1967-76. 2003
  6. ncbi Different epidemic curves for severe acute respiratory syndrome reveal similar impacts of control measures
    Jacco Wallinga
    National Institute for Public Health and the Environment, Bilthoven, The Netherlands
    Am J Epidemiol 160:509-16. 2004
  7. pmc Reverse genetics with a full-length infectious cDNA of severe acute respiratory syndrome coronavirus
    Boyd Yount
    Department of Epidemiology and Microbiology, University of North Carolina, Chapel Hill, NC 27599 7435, USA
    Proc Natl Acad Sci U S A 100:12995-3000. 2003
  8. pmc A small-molecule oxocarbazate inhibitor of human cathepsin L blocks severe acute respiratory syndrome and ebola pseudotype virus infection into human embryonic kidney 293T cells
    Parag P Shah
    Department of Chemical and Biomolecular Engineering, Penn Center for Molecular Discovery, Institute for Medicine and Engineering, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6383, USA
    Mol Pharmacol 78:319-24. 2010
  9. pmc Inhibitors of cathepsin L prevent severe acute respiratory syndrome coronavirus entry
    Graham Simmons
    Department of Microbiology, School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 102:11876-81. 2005
  10. pmc Induction of alternatively activated macrophages enhances pathogenesis during severe acute respiratory syndrome coronavirus infection
    Carly Page
    Department of Microbiology and Immunology, University of Maryland at Baltimore, Baltimore, Maryland, USA
    J Virol 86:13334-49. 2012

Research Grants

Detail Information

Publications391 found, 100 shown here

  1. ncbi Bats are natural reservoirs of SARS-like coronaviruses
    Wendong Li
    Institute of Zoology, Chinese Academy of Sciences CAS, Beijing, China
    Science 310:676-9. 2005
    b>Severe acute respiratory syndrome (SARS) emerged in 2002 to 2003 in southern China. The origin of its etiological agent, the SARS coronavirus (SARS-CoV), remains elusive...
  2. pmc Transmission dynamics and control of severe acute respiratory syndrome
    Marc Lipsitch
    Department of Epidemiology, Harvard School of Public Health, 677 Huntington Avenue, Boston, MA 02115, USA
    Science 300:1966-70. 2003
    b>Severe acute respiratory syndrome (SARS) is a recently described illness of humans that has spread widely over the past 6 months...
  3. ncbi Network theory and SARS: predicting outbreak diversity
    Lauren Ancel Meyers
    Section of Integrative Biology and Institute for Cellular and Molecular Biology, University of Texas at Austin, 1 University Station C0930, Austin, TX 78712, USA
    J Theor Biol 232:71-81. 2005
    ..Applications of compartmental models to Severe Acute Respiratory Syndrome (SARS) resulted in estimates of the fundamental quantity called the basic reproductive number R0--..
  4. ncbi Severe acute respiratory syndrome
    J S M Peiris
    Department of Microbiology, The University of Hong Kong, University Pathology Building, Queen Mary Hospital, Pokfualm, Hong Kong Special Administrative Region of China
    Nat Med 10:S88-97. 2004
    b>Severe acute respiratory syndrome (SARS) was caused by a previously unrecognized animal coronavirus that exploited opportunities provided by 'wet markets' in southern China to adapt to become a virus readily transmissible between humans...
  5. ncbi Identification of a novel coronavirus in patients with severe acute respiratory syndrome
    Christian Drosten
    Bernhard Nocht Institute for Tropical Medicine, National Reference Center for Tropical Infectious Diseases, Hamburg, Germany
    N Engl J Med 348:1967-76. 2003
    The severe acute respiratory syndrome (SARS) has recently been identified as a new clinical entity. SARS is thought to be caused by an unknown infectious agent.
  6. ncbi Different epidemic curves for severe acute respiratory syndrome reveal similar impacts of control measures
    Jacco Wallinga
    National Institute for Public Health and the Environment, Bilthoven, The Netherlands
    Am J Epidemiol 160:509-16. 2004
    b>Severe acute respiratory syndrome (SARS) has been the first severe contagious disease to emerge in the 21st century...
  7. pmc Reverse genetics with a full-length infectious cDNA of severe acute respiratory syndrome coronavirus
    Boyd Yount
    Department of Epidemiology and Microbiology, University of North Carolina, Chapel Hill, NC 27599 7435, USA
    Proc Natl Acad Sci U S A 100:12995-3000. 2003
    A previously undescribed coronavirus (CoV) is the etiologic agent responsible for severe acute respiratory syndrome (SARS)...
  8. pmc A small-molecule oxocarbazate inhibitor of human cathepsin L blocks severe acute respiratory syndrome and ebola pseudotype virus infection into human embryonic kidney 293T cells
    Parag P Shah
    Department of Chemical and Biomolecular Engineering, Penn Center for Molecular Discovery, Institute for Medicine and Engineering, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6383, USA
    Mol Pharmacol 78:319-24. 2010
    ..4.22.15) and as an entry blocker of severe acute respiratory syndrome (SARS) coronavirus and Ebola pseudotype virus...
  9. pmc Inhibitors of cathepsin L prevent severe acute respiratory syndrome coronavirus entry
    Graham Simmons
    Department of Microbiology, School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 102:11876-81. 2005
    b>Severe acute respiratory syndrome (SARS) is caused by an emergent coronavirus (SARS-CoV), for which there is currently no effective treatment...
  10. pmc Induction of alternatively activated macrophages enhances pathogenesis during severe acute respiratory syndrome coronavirus infection
    Carly Page
    Department of Microbiology and Immunology, University of Maryland at Baltimore, Baltimore, Maryland, USA
    J Virol 86:13334-49. 2012
    Infection with severe acute respiratory syndrome coronavirus (SARS-CoV) causes acute lung injury (ALI) that often leads to severe lung disease...
  11. ncbi Identification of oxidative stress and Toll-like receptor 4 signaling as a key pathway of acute lung injury
    Yumiko Imai
    IMBA, Institute of Molecular Biotechnology of the Austrian Academy of Sciences, Dr Bohrgasse 3, A 1030 Vienna, Austria
    Cell 133:235-49. 2008
    ..Moreover, deletion of ncf1, which controls ROS production, improves the severity of H5N1-mediated ALI. Our data identify oxidative stress and innate immunity as key lung injury pathways that control the severity of ALI...
  12. pmc Dynamic innate immune responses of human bronchial epithelial cells to severe acute respiratory syndrome-associated coronavirus infection
    Tomoki Yoshikawa
    Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, Texas, United States of America
    PLoS ONE 5:e8729. 2010
    Human lung epithelial cells are likely among the first targets to encounter invading severe acute respiratory syndrome-associated coronavirus (SARS-CoV)...
  13. pmc Incidence of influenza-like illness and severe acute respiratory infection during three influenza seasons in Bangladesh, 2008-2010
    Eduardo Azziz-Baumgartner
    International Centre for Diarrhoeal Disease Research, 68, Shaheed Tajuddin Ahmed, Sarani, Mohakhali, Dhaka 1212, Bangladesh
    Bull World Health Organ 90:12-9. 2012
    ..To determine how much influenza contributes to severe acute respiratory illness (SARI), a leading cause of death in children, among people of all ages in Bangladesh...
  14. ncbi CD209 (DC-SIGN) -336A>G promoter polymorphism and severe acute respiratory syndrome in Hong Kong Chinese
    Kelvin Yuen Kwong Chan
    Department of Pathology, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong SAR, China
    Hum Immunol 71:702-7. 2010
    ..CD209 facilitates severe acute respiratory syndrome (SARS)-coronavirus spike protein-bearing pseudotype driven infection of permissive cells in vitro...
  15. pmc Protective effects of long pentraxin PTX3 on lung injury in a severe acute respiratory syndrome model in mice
    Bing Han
    Latner Thoracic Surgery Research Laboratories, University Health Network Toronto General Hospital, Toronto, Ontario, Canada
    Lab Invest 92:1285-96. 2012
    The outbreak of severe acute respiratory syndrome (SARS) in 2003 reinforces the potential of lethal pandemics of respiratory viral infections. The underlying mechanisms of SARS are still largely undefined...
  16. ncbi Lung pathology of fatal severe acute respiratory syndrome
    John M Nicholls
    Department of Pathology, University of Hong Kong, Hong Kong Special Administrative Region, China
    Lancet 361:1773-8. 2003
    b>Severe acute respiratory syndrome (SARS) is a novel infectious disease with global impact. A virus from the family Coronaviridae has been identified as the cause, but the pathogenesis is still unclear.
  17. pmc Coronavirus pathogenesis and the emerging pathogen severe acute respiratory syndrome coronavirus
    Susan R Weiss
    Department of Microbiology, University of Pennsylvania School of Medicine, 36th Street and Hamilton Walk, Philadelphia, Pennsylvania 19104 6076, USA
    Microbiol Mol Biol Rev 69:635-64. 2005
    ..family consists of pathogens of many animal species and of humans, including the recently isolated severe acute respiratory syndrome coronavirus (SARS-CoV)...
  18. pmc Avian influenza virus, Streptococcus suis serotype 2, severe acute respiratory syndrome-coronavirus and beyond: molecular epidemiology, ecology and the situation in China
    Ying Ma
    CAS Key Laboratory of Pathogenic Microbiology and Immunology CASPMI, Institute of Microbiology, Chinese Academy of Sciences CAS, Beijing 100101, The People s Republic of China
    Philos Trans R Soc Lond B Biol Sci 364:2725-37. 2009
    The outbreak and spread of severe acute respiratory syndrome-associated coronavirus and the subsequent identification of its animal origin study have heightened the world's awareness of animal-borne or zoonotic pathogens...
  19. pmc Recombination, reservoirs, and the modular spike: mechanisms of coronavirus cross-species transmission
    Rachel L Graham
    Department of Epidemiology, School of Public Health, University of North Carolina at Chapel Hill, 2105D McGaveran Greenberg Hall, CB7, Chapel Hill, NC 27599, USA
    J Virol 84:3134-46. 2010
    ..Most notable is severe acute respiratory syndrome (SARS), a lower respiratory tract disease of humans that was first reported in late 2002 in ..
  20. ncbi Transmission of the severe acute respiratory syndrome on aircraft
    Sonja J Olsen
    International Emerging Infections Program, Centers for Disease Control and Prevention, Nonthaburi, Thailand
    N Engl J Med 349:2416-22. 2003
    The severe acute respiratory syndrome (SARS) spread rapidly around the world, largely because persons infected with the SARS-associated coronavirus (SARS-CoV) traveled on aircraft to distant cities...
  21. pmc Regulation of IRF-3-dependent innate immunity by the papain-like protease domain of the severe acute respiratory syndrome coronavirus
    Santhana G Devaraj
    Department of Microbiology and Immunology, Center of Biodefense and Emerging Infectious Diseases, Institute for Human Infections and Immunity, University of Texas Medical Branch, Galveston, TX 77555 1019, USA
    J Biol Chem 282:32208-21. 2007
    b>Severe acute respiratory syndrome coronavirus (SARS-CoV) is a novel coronavirus that causes a highly contagious respiratory disease, SARS, with significant mortality...
  22. pmc The spike protein of SARS-CoV--a target for vaccine and therapeutic development
    Lanying Du
    Lindsley F Kimball Research Institute, New York Blood Center, 310 East 67th Street, New York, NY 10065, USA
    Nat Rev Microbiol 7:226-36. 2009
    b>Severe acute respiratory syndrome (SARS) is a newly emerging infectious disease caused by a novel coronavirus, SARS-coronavirus (SARS-CoV)...
  23. ncbi Tissue distribution of ACE2 protein, the functional receptor for SARS coronavirus. A first step in understanding SARS pathogenesis
    I Hamming
    Department of Pathology and Laboratory Medicine, University Hospital Groningen, The Netherlands
    J Pathol 203:631-7. 2004
    b>Severe acute respiratory syndrome (SARS) is an acute infectious disease that spreads mainly via the respiratory route. A distinct coronavirus (SARS-CoV) has been identified as the aetiological agent of SARS...
  24. pmc Infidelity of SARS-CoV Nsp14-exonuclease mutant virus replication is revealed by complete genome sequencing
    Lance D Eckerle
    Department of Pediatrics and Microbiology and Immunology and Elizabeth B Lamb Center for Pediatric Research, Vanderbilt University Medical Center, Nashville, Tennessee, USA
    PLoS Pathog 6:e1000896. 2010
    ..We report here the engineering and recovery of nsp14-ExoN mutant viruses of severe acute respiratory syndrome coronavirus (SARS-CoV) that have stable growth defects and demonstrate a 21-fold increase in ..
  25. pmc Longitudinally profiling neutralizing antibody response to SARS coronavirus with pseudotypes
    Nigel J Temperton
    Wohl Virion Centre and Division of Infection and Immunity, University College London, 46 Cleveland St, London W1T 4JF, London, UK
    Emerg Infect Dis 11:411-6. 2005
    The severe acute respiratory syndrome-associated coronavirus (SARS-CoV) spike protein (S) is a major target for neutralizing antibodies...
  26. ncbi Molecular epidemiology of the novel coronavirus that causes severe acute respiratory syndrome
    Y Guan
    Department of Microbiology, University of Hong Kong, Hong Kong SAR, China
    Lancet 363:99-104. 2004
    b>Severe acute respiratory syndrome (SARS) is a newly emerged disease caused by a novel coronavirus (SARS-CoV), which spread globally in early 2003, affecting over 30 countries...
  27. pmc Human monoclonal antibody combination against SARS coronavirus: synergy and coverage of escape mutants
    Jan Ter Meulen
    Crucell Holland B V, Leiden, Netherlands
    PLoS Med 3:e237. 2006
    Experimental animal data show that protection against severe acute respiratory syndrome coronavirus (SARS-CoV) infection with human monoclonal antibodies (mAbs) is feasible...
  28. ncbi The severe acute respiratory syndrome
    Joseph S M Peiris
    Department of Microbiology and Division of Infectious Diseases, The University of Hong Kong, Hong Kong
    N Engl J Med 349:2431-41. 2003
  29. pmc Neutralizing human monoclonal antibodies to severe acute respiratory syndrome coronavirus: target, mechanism of action, and therapeutic potential
    Melissa M Coughlin
    Centers for Disease Control and Prevention, Measles, Mumps, Rubella and Herpes Virus Laboratory Branch, Atlanta, GA, USA
    Rev Med Virol 22:2-17. 2012
    The emergence of Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) led to a rapid response not only to contain the outbreak but also to identify possible therapeutic interventions, including the generation of human monoclonal ..
  30. pmc Cellular immune responses to severe acute respiratory syndrome coronavirus (SARS-CoV) infection in senescent BALB/c mice: CD4+ T cells are important in control of SARS-CoV infection
    Jun Chen
    Laboratory of Infectious Diseases, National Institute for Allergy and Infectious Diseases, NIH, Bethesda, Maryland 20892 3203, USA
    J Virol 84:1289-301. 2010
    We characterized the cellular immune response to severe acute respiratory syndrome coronavirus (SARS-CoV) infection in 12- to 14-month-old BALB/c mice, a model that mimics features of the human disease...
  31. pmc A SARS DNA vaccine induces neutralizing antibody and cellular immune responses in healthy adults in a Phase I clinical trial
    Julie E Martin
    Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 40 Convent Drive, MSC 2610, Bethesda, MD 20892 3017, USA
    Vaccine 26:6338-43. 2008
    The severe acute respiratory syndrome (SARS) virus is a member of the Coronaviridae (CoV) family that first appeared in the Guangdong Province of China in 2002 and was recognized as an emerging infectious disease in March 2003...
  32. pmc Low usage of government healthcare facilities for acute respiratory infections in guatemala: implications for influenza surveillance
    Kim A Lindblade
    Centers for Disease Control and Prevention CDC, Atlanta GA, 30333 USA
    BMC Public Health 11:885. 2011
    ..The objective of this study was to measure healthcare utilization patterns in Guatemala to inform the establishment of a sentinel surveillance system for influenza and other respiratory infections, and allow estimation of disease burden...
  33. ncbi Structural basis of neutralization by a human anti-severe acute respiratory syndrome spike protein antibody, 80R
    William C Hwang
    Infectious and Inflammatory Disease Center, Burnham Institute for Medical Research, La Jolla, California 92037, USA
    J Biol Chem 281:34610-6. 2006
    b>Severe acute respiratory syndrome (SARS) is a newly emerged infectious disease that caused pandemic spread in 2003. The etiological agent of SARS is a novel coronavirus (SARS-CoV)...
  34. pmc Human cell tropism and innate immune system interactions of human respiratory coronavirus EMC compared to those of severe acute respiratory syndrome coronavirus
    Florian Zielecki
    Institute for Virology, Philipps University Marburg, Marburg, Germany
    J Virol 87:5300-4. 2013
    ..We demonstrate that HCoV-EMC resembles severe acute respiratory syndrome coronavirus (SARS-CoV) in productively infecting primary and continuous cells of the human airways ..
  35. pmc Complete protection against severe acute respiratory syndrome coronavirus-mediated lethal respiratory disease in aged mice by immunization with a mouse-adapted virus lacking E protein
    Craig Fett
    Department of Microbiology, University of Iowa, Iowa City, Iowa, USA
    J Virol 87:6551-9. 2013
    Zoonotic coronaviruses, including the one that caused severe acute respiratory syndrome (SARS), cause significant morbidity and mortality in humans...
  36. pmc Retroviral vectors pseudotyped with severe acute respiratory syndrome coronavirus S protein
    Tsanan Giroglou
    Georg Speyer Haus, Institute for Biomedical Research, Frankfurt University Medical School, Frankfurt, Germany
    J Virol 78:9007-15. 2004
    The worldwide outbreak of severe acute respiratory syndrome (SARS) was shown to be associated with a novel coronavirus (CoV) now called SARS CoV...
  37. ncbi Aetiology: Koch's postulates fulfilled for SARS virus
    Ron A M Fouchier
    Department of Virology, Erasmus Medical Centre, 3015 GE Rotterdam, The Netherlands
    Nature 423:240. 2003
  38. ncbi Comparative evaluation of two severe acute respiratory syndrome (SARS) vaccine candidates in mice challenged with SARS coronavirus
    Raymond H See
    University of British Columbia Centre for Disease Control, Vancouver, BC V5Z 4R4, Canada
    J Gen Virol 87:641-50. 2006
    Two different severe acute respiratory syndrome (SARS) vaccine strategies were evaluated for their ability to protect against live SARS coronavirus (CoV) challenge in a murine model of infection...
  39. ncbi Identification of a minimal peptide derived from heptad repeat (HR) 2 of spike protein of SARS-CoV and combination of HR1-derived peptides as fusion inhibitors
    I Jung Liu
    Institute of Microbiology, College of Medicine, National Taiwan University, Taipei 100, Taiwan
    Antiviral Res 81:82-7. 2009
    ..39+/-0.05 microM and combination index of 0.75+/-0.15, suggesting a common strategy to achieve promising inhibition by HR1 peptide for other class I envelope viruses...
  40. ncbi Fully human monoclonal antibody directed to proteolytic cleavage site in severe acute respiratory syndrome (SARS) coronavirus S protein neutralizes the virus in a rhesus macaque SARS model
    Tohru Miyoshi-Akiyama
    Department of Infectious Diseases, National Center for Global Health and Medicine, 1 21 1 Toyama, Shinjuku ku, Tokyo 162 8655, Japan
    J Infect Dis 203:1574-81. 2011
    There is still no effective method to prevent or treat severe acute respiratory syndrome (SARS), which is caused by SARS coronavirus (CoV)...
  41. pmc Forecast and control of epidemics in a globalized world
    L Hufnagel
    Max Planck Institut für Strömungsforschung, Bunsenstrasse 10, 37073 Gottingen, Germany
    Proc Natl Acad Sci U S A 101:15124-9. 2004
    The rapid worldwide spread of severe acute respiratory syndrome demonstrated the potential threat an infectious disease poses in a closely interconnected and interdependent world...
  42. pmc A double-inactivated severe acute respiratory syndrome coronavirus vaccine provides incomplete protection in mice and induces increased eosinophilic proinflammatory pulmonary response upon challenge
    Meagan Bolles
    Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    J Virol 85:12201-15. 2011
    b>Severe acute respiratory syndrome coronavirus (SARS-CoV) is an important emerging virus that is highly pathogenic in aged populations and is maintained with great diversity in zoonotic reservoirs...
  43. ncbi Rapid detection of the severe acute respiratory syndrome (SARS) coronavirus by a loop-mediated isothermal amplification assay
    Leo L M Poon
    Department of Microbiology, Queen Mary Hospital, University of Hong Kong, Hong Kong SAR
    Clin Chem 50:1050-2. 2004
  44. pmc Quantitative proteomics analysis reveals BAG3 as a potential target to suppress severe acute respiratory syndrome coronavirus replication
    Liang Zhang
    Division of Research, Singapore Health Research Facilities, 7 Hospital Drive, Singapore 169611, Republic of Singapore
    J Virol 84:6050-9. 2010
    The discovery of a novel coronavirus (CoV) as the causative agent of severe acute respiratory syndrome (SARS) has highlighted the need for a better understanding of CoV replication...
  45. ncbi The Immunobiology of SARS*
    Jun Chen
    Laboratory of Infectious Diseases, NIAID, NIH, Bethesda, Maryland 20892, USA
    Annu Rev Immunol 25:443-72. 2007
    b>Severe acute respiratory syndrome (SARS) presented as an atypical pneumonia that progressed to acute respiratory distress syndrome in approximately 20% of cases and was associated with a mortality of about 10%...
  46. ncbi Annexin A2 on lung epithelial cell surface is recognized by severe acute respiratory syndrome-associated coronavirus spike domain 2 antibodies
    Yi Ting Fang
    Institute of Basic Medical Sciences, National Cheng Kung University Medical College, Tainan, Taiwan
    Mol Immunol 47:1000-9. 2010
    b>Severe acute respiratory syndrome-associated coronavirus (SARS-CoV) infection causes lung failure characterized by atypical pneumonia...
  47. pmc Characterization of severe acute respiratory syndrome-associated coronavirus (SARS-CoV) spike glycoprotein-mediated viral entry
    Graham Simmons
    Department of Microbiology, University of Pennsylvania School of Medicine, 225 Johnson Pavilion, 3610 Hamilton Walk, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 101:4240-5. 2004
    b>Severe acute respiratory syndrome-associated coronavirus (SARS-CoV) is a rapidly emerging pathogen with potentially serious consequences for public health...
  48. pmc Efficient activation of the severe acute respiratory syndrome coronavirus spike protein by the transmembrane protease TMPRSS2
    Shutoku Matsuyama
    Department of Virology III, National Institute of Infectious Diseases, Japan, 4 7 1 Gakuen, Musashi Murayama, Tokyo 208 0011, Japan
    J Virol 84:12658-64. 2010
    The distribution of the severe acute respiratory syndrome coronavirus (SARS-CoV) receptor, an angiotensin-converting enzyme 2 (ACE2), does not strictly correlate with SARS-CoV cell tropism in lungs; therefore, other cellular factors have ..
  49. pmc Early upregulation of acute respiratory distress syndrome-associated cytokines promotes lethal disease in an aged-mouse model of severe acute respiratory syndrome coronavirus infection
    Barry Rockx
    Department of Microbiology, University of North Carolina, Chapel Hill, North Carolina, USA
    J Virol 83:7062-74. 2009
    Several respiratory viruses, including influenza virus and severe acute respiratory syndrome coronavirus (SARS-CoV), produce more severe disease in the elderly, yet the molecular mechanisms governing age-related susceptibility remain ..
  50. pmc Cytokine responses in severe acute respiratory syndrome coronavirus-infected macrophages in vitro: possible relevance to pathogenesis
    Chung Y Cheung
    Department of Microbiology, University Pathology Building, Queen Mary Hospital, Pokfulam Road, Hong Kong, Special Administrative Region, People s Republic of China
    J Virol 79:7819-26. 2005
    The pathogenesis of severe acute respiratory syndrome (SARS) remains unclear...
  51. pmc Rhesus theta-defensin prevents death in a mouse model of severe acute respiratory syndrome coronavirus pulmonary disease
    Christine L Wohlford-Lenane
    Department of Pediatrics, Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242, USA
    J Virol 83:11385-90. 2009
    ..1 (RTD-1), a novel cyclic antimicrobial peptide, as a prophylactic antiviral in a mouse model of severe acute respiratory syndrome (SARS) coronavirus (CoV) lung disease...
  52. pmc Severe acute respiratory syndrome coronavirus as an agent of emerging and reemerging infection
    Vincent C C Cheng
    State Key Laboratory of Emerging Infectious Diseases, Department of Microbiology, Research Centre of Infection and Immunology, The University of Hong Kong, Hong Kong Special Administrative Region, China
    Clin Microbiol Rev 20:660-94. 2007
    Before the emergence of severe acute respiratory syndrome (SARS) coronavirus (SARS-CoV) in 2003, only 12 other animal or human coronaviruses were known...
  53. ncbi Immunopathogenesis of coronavirus infections: implications for SARS
    Stanley Perlman
    Interdisciplinary Program in Immunology, University of Iowa, Iowa City, Iowa 52242, USA
    Nat Rev Immunol 5:917-27. 2005
    At the end of 2002, the first cases of severe acute respiratory syndrome (SARS) were reported, and in the following year, SARS resulted in considerable mortality and morbidity worldwide...
  54. ncbi A novel coronavirus associated with severe acute respiratory syndrome
    Thomas G Ksiazek
    Special Pathogens Branch, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, USA
    N Engl J Med 348:1953-66. 2003
    A worldwide outbreak of severe acute respiratory syndrome (SARS) has been associated with exposures originating from a single ill health care worker from Guangdong Province, China...
  55. pmc Synthetic recombinant bat SARS-like coronavirus is infectious in cultured cells and in mice
    Michelle M Becker
    Departments of Pediatrics and Microbiology and Immunology, Vanderbilt University, Nashville, TN 37232, USA
    Proc Natl Acad Sci U S A 105:19944-9. 2008
    ..7-kb bat severe acute respiratory syndrome (SARS)-like coronavirus (Bat-SCoV), a likely progenitor to the SARS-CoV epidemic...
  56. pmc A severe acute respiratory syndrome coronavirus that lacks the E gene is attenuated in vitro and in vivo
    Marta L DeDiego
    Department of Molecular and Cell Biology, Centro Nacional de Biotecnologia, CSIC, Darwin 3, Campus Universidad Autonoma, Cantoblanco, 28049 Madrid, Spain
    J Virol 81:1701-13. 2007
    A deletion mutant of severe acute respiratory syndrome coronavirus (SARS-CoV) has been engineered by deleting the structural E gene in an infectious cDNA clone that was constructed as a bacterial artificial chromosome (BAC)...
  57. ncbi SARS coronavirus entry into host cells through a novel clathrin- and caveolae-independent endocytic pathway
    Hongliang Wang
    National Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Peking Union Medical College, Tsinghua University and Chinese Academy of Medical Sciences, Beijing 100005, China
    Cell Res 18:290-301. 2008
    While severe acute respiratory syndrome coronavirus (SARS-CoV) was initially thought to enter cells through direct fusion with the plasma membrane, more recent evidence suggests that virus entry may also involve endocytosis...
  58. ncbi Seasonality of infectious diseases and severe acute respiratory syndrome-what we don't know can hurt us
    Scott F Dowell
    International Emerging Infections Program, Thai Ministry of Public Health and the US Centers for Disease Control and Prevention, Nonthaburi, Thailand
    Lancet Infect Dis 4:704-8. 2004
    The novel severe acute respiratory syndrome (SARS) coronavirus caused severe disease and heavy economic losses before apparently coming under complete control...
  59. pmc Expression profile of immune response genes in patients with Severe Acute Respiratory Syndrome
    Renji Reghunathan
    Department of Physiology, National University of Singapore, Singapore
    BMC Immunol 6:2. 2005
    b>Severe acute respiratory syndrome (SARS) emerged in later February 2003, as a new epidemic form of life-threatening infection caused by a novel coronavirus. However, the immune-pathogenesis of SARS is poorly understood...
  60. pmc Ecoepidemiology and complete genome comparison of different strains of severe acute respiratory syndrome-related Rhinolophus bat coronavirus in China reveal bats as a reservoir for acute, self-limiting infection that allows recombination events
    Susanna K P Lau
    State Key Laboratory of Emerging Infectious Diseases, Research Centre of Infection and Immunology, Department of Microbiology, The University of Hong Kong, Hong Kong, Hong Kong
    J Virol 84:2808-19. 2010
    Despite the identification of severe acute respiratory syndrome-related coronavirus (SARSr-CoV) in Rhinolophus Chinese horseshoe bats (SARSr-Rh-BatCoV) in China, the evolutionary and possible recombination origin of SARSr-CoV remains ..
  61. pmc The interferon gamma gene polymorphism +874 A/T is associated with severe acute respiratory syndrome
    Wai Po Chong
    Department of Paediatrics and Adolescent Medicine, The Hong Kong Jockey Club Research Centre, The University of Hong Kong, Pokfulam, Hong Kong SAR, China
    BMC Infect Dis 6:82. 2006
    Cytokines play important roles in antiviral action. We examined whether polymorphisms of IFN-gamma,TNF-alpha and IL-10 affect the susceptibility to and outcome of severe acute respiratory syndrome (SARS).
  62. ncbi A cluster of cases of severe acute respiratory syndrome in Hong Kong
    Kenneth W Tsang
    University Department of Medicine, University of Hong Kong, Pokfulam, China
    N Engl J Med 348:1977-85. 2003
    Information on the clinical features of the severe acute respiratory syndrome (SARS) will be of value to physicians caring for patients suspected of having this disorder.
  63. ncbi Bats, civets and the emergence of SARS
    L F Wang
    CSIRO Livestock Industries, Australian Animal Health Laboratory, Geelong, Victoria, 3220 Australia
    Curr Top Microbiol Immunol 315:325-44. 2007
    b>Severe acute respiratory syndrome (SARS) was the first pandemic transmissible disease of previously unknown aetiology in the twenty-first century. Early epidemiologic investigations suggested an animal origin for SARS-CoV...
  64. pmc Global surveillance, national surveillance, and SARS
    David L Heymann
    World Health Organization, Geneva, Switzerland
    Emerg Infect Dis 10:173-5. 2004
  65. ncbi Coronavirus as a possible cause of severe acute respiratory syndrome
    J S M Peiris
    Department of Microbiology and Pathology, Queen Mary Hospital, University of Hong Kong, Special Administrative Region, Hong Kong, China
    Lancet 361:1319-25. 2003
    An outbreak of severe acute respiratory syndrome (SARS) has been reported in Hong Kong. We investigated the viral cause and clinical presentation among 50 patients.
  66. pmc Development and evaluation of a novel loop-mediated isothermal amplification method for rapid detection of severe acute respiratory syndrome coronavirus
    Thi Cam Thai Hong
    Department of Virology, Institute of Tropical Medicine, Nagasaki University, Nagasaki 852 8523, Japan
    J Clin Microbiol 42:1956-61. 2004
    ..RT) loop-mediated isothermal amplification (LAMP) assay is reported for rapid detection of the severe acute respiratory syndrome coronavirus (SARS-CoV) replicase gene...
  67. pmc Successful vaccination strategies that protect aged mice from lethal challenge from influenza virus and heterologous severe acute respiratory syndrome coronavirus
    Timothy Sheahan
    Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, NC 27699 7435, USA
    J Virol 85:217-30. 2011
    ..The newly emerging severe acute respiratory syndrome coronavirus (SARS-CoV) and reemerging influenza virus cause disproportionate disease in the aged, ..
  68. pmc Progress in global surveillance and response capacity 10 years after severe acute respiratory syndrome
    Christopher R Braden
    Division of Foodborne, Waterborne and Environmental Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    Emerg Infect Dis 19:864-9. 2013
    ..since the World Health Organization issued its first global alert for an unexplained illness named severe acute respiratory syndrome (SARS)...
  69. pmc Role of lopinavir/ritonavir in the treatment of SARS: initial virological and clinical findings
    C M Chu
    Department of Microbiology and Medicine, Queen Mary Hospital, The University of Hong Kong, Hong Kong
    Thorax 59:252-6. 2004
    The clinical response of patients with severe acute respiratory syndrome (SARS) to a combination of lopinavir/ritonavir and ribavirin was examined after establishing the in vitro antiviral susceptibility of the SARS associated ..
  70. ncbi Treatment of severe acute respiratory syndrome with lopinavir/ritonavir: a multicentre retrospective matched cohort study
    K S Chan
    Department of Medicine and Geriatrics, United Christian Hospital, 130 Hip Wo Street, Kwun Tong, Hong Kong
    Hong Kong Med J 9:399-406. 2003
    To investigate the possible benefits and adverse effects of the addition of lopinavir/ritonavir to a standard treatment protocol for the treatment of severe acute respiratory syndrome.
  71. ncbi Experience of using convalescent plasma for severe acute respiratory syndrome among healthcare workers in a Taiwan hospital
    Kuo Ming Yeh
    Division of Infectious Diseases and Tropical Medicine, Department of Internal Medicine, Tri Service General Hospital, National Defense Medical Center, No 325, Cheng Kung Road, Sec 2, Neihu, Taipei, 114, Taiwan
    J Antimicrob Chemother 56:919-22. 2005
    ..To describe the immunological responses and clinical outcome of coronavirus (SARS) infected healthcare workers (HCW) who had been administered with convalescent plasma as a treatment...
  72. ncbi SARS-associated coronavirus
    Kathryn V Holmes
    University of Colorado Health Sciences Center, Denver, USA
    N Engl J Med 348:1948-51. 2003
  73. pmc Monoclonal antibodies targeting the HR2 domain and the region immediately upstream of the HR2 of the S protein neutralize in vitro infection of severe acute respiratory syndrome coronavirus
    Kuo Ming Lip
    Institute of Molecular and Cell Biology, Proteos, 61 Biopolis Drive, Singapore 138673
    J Virol 80:941-50. 2006
    ..These results provide evidence of novel neutralizing epitopes that are located in the HR2 domain and the spacer region immediately upstream of the HR2 of the S protein...
  74. ncbi Acute renal impairment in coronavirus-associated severe acute respiratory syndrome
    Kwok Hong Chu
    Department of Medicine and Geriatrics, Princess Margaret Hospital, Hong Kong
    Kidney Int 67:698-705. 2005
    b>Severe acute respiratory syndrome (SARS) is a newly emerged infection from a novel coronavirus (SARS-CoV). Apart from fever and respiratory complications, acute renal impairment has been observed in some patients with SARS...
  75. ncbi Monoclonal antibodies to SARS-associated coronavirus (SARS-CoV): identification of neutralizing and antibodies reactive to S, N, M and E viral proteins
    Ralph A Tripp
    National Centers for Infectious Diseases, Division of Viral and Rickettsial Diseases, Respiratory and Enteric Virus Branch, Centers for Disease Control and Prevention, 1600 Clifton Rd NE, Mailstop G 09, Atlanta, GA 30333, USA
    J Virol Methods 128:21-8. 2005
    ..The mAbs characterized should prove useful for developing SARS-CoV diagnostic assays and for studying the biology of infection and pathogenesis of disease...
  76. ncbi Adverse effects of ribavirin and outcome in severe acute respiratory syndrome: experience in two medical centers
    Hsueh Erh Chiou
    Division of Chest Medicine, Department of Internal Medicine, Mackay Memorial Hospital, 92 Sec 2 Chung Shan North Road, Taipei 10449, Taiwan
    Chest 128:263-72. 2005
    To assess the effect of ribavirin-induced anemia on the outcome of severe acute respiratory syndrome (SARS).
  77. ncbi Detection of severe acute respiratory syndrome-associated coronavirus in pneumocytes of the lung
    Kuan Chih Chow
    Institute of Biomedical Sciences, National Chung Hsing University, Taichung, Taiwan
    Am J Clin Pathol 121:574-80. 2004
    Previous reports have indicated that patients with severe acute respiratory syndrome (SARS)-associated coronavirus infection could develop atypical pneumonia with fulminant pulmonary edema...
  78. pmc S protein of severe acute respiratory syndrome-associated coronavirus mediates entry into hepatoma cell lines and is targeted by neutralizing antibodies in infected patients
    Heike Hofmann
    Institute for Clinical and Molecular Virology, University Erlangen Nurnberg, Nikolaus Fiebiger Center, Glückstrasse 6, D 91054 Erlangen, Germany
    J Virol 78:6134-42. 2004
    The severe acute respiratory syndrome-associated coronavirus (SARS-CoV) causes severe pneumonia with a fatal outcome in approximately 10% of patients...
  79. ncbi Nucleocapsid protein of SARS coronavirus tightly binds to human cyclophilin A
    Cheng Luo
    Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 201203, China
    Biochem Biophys Res Commun 321:557-65. 2004
    b>Severe acute respiratory syndrome coronavirus (SARS-CoV) is responsible for SARS infection...
  80. ncbi A crucial role of angiotensin converting enzyme 2 (ACE2) in SARS coronavirus-induced lung injury
    Keiji Kuba
    Institute of Molecular Biotechnology of the Austrian Academy of Sciences, Dr Bohr Gasse 7, A 1030 Vienna, Austria
    Nat Med 11:875-9. 2005
    During several months of 2003, a newly identified illness termed severe acute respiratory syndrome (SARS) spread rapidly through the world...
  81. pmc Mutational dynamics of the SARS coronavirus in cell culture and human populations isolated in 2003
    Vinsensius B Vega
    Genome Institute of Singapore, 60 Biopolis Street, Singapore 138672
    BMC Infect Dis 4:32. 2004
    The SARS coronavirus is the etiologic agent for the epidemic of the Severe Acute Respiratory Syndrome. The recent emergence of this new pathogen, the careful tracing of its transmission patterns, and the ability to propagate in culture ..
  82. pmc Model parameters and outbreak control for SARS
    Gerardo Chowell
    Los Alamos National Laboratory, New Mexico, USA
    Emerg Infect Dis 10:1258-63. 2004
    Control of the 2002-2003 severe acute respiratory syndrome (SARS) outbreak was based on rapid diagnosis coupled with effective patient isolation...
  83. ncbi Severe acute respiratory syndrome (SARS): development of diagnostics and antivirals
    Morten Draeby Sørensen
    Department of Molecular Biology, University of Aarhus, Denmark
    Ann N Y Acad Sci 1067:500-5. 2006
    The previously unknown coronavirus that caused severe acute respiratory syndrome (SARS-CoV) affected more than 8,000 persons worldwide and was responsible for more than 700 deaths during the first outbreak in 2002-2003...
  84. pmc Evasion by stealth: inefficient immune activation underlies poor T cell response and severe disease in SARS-CoV-infected mice
    Jincun Zhao
    Department of Microbiology, University of Iowa, Iowa City, Iowa, USA
    PLoS Pathog 5:e1000636. 2009
    b>Severe Acute Respiratory Syndrome caused substantial morbidity and mortality during the 2002-2003 epidemic...
  85. ncbi Severe acute respiratory syndrome vaccine development: experiences of vaccination against avian infectious bronchitis coronavirus
    Dave Cavanagh
    Institute for Animal Health, Division of Molecular Biology, Compton Laboratory, Newbury, Berkshire, UK
    Avian Pathol 32:567-82. 2003
    ..Meleagris gallopovo) and ring-necked pheasant (Phasianus colchicus), is a group 3 coronavirus, severe acute respiratory syndrome (SARS) coronavirus being tentatively in group 4, the other known mammalian coronaviruses being in ..
  86. ncbi The ADP-ribose-1''-monophosphatase domains of severe acute respiratory syndrome coronavirus and human coronavirus 229E mediate resistance to antiviral interferon responses
    Thomas Kuri
    Department of Virology, University of Freiburg, D 79008 Freiburg, Germany
    J Gen Virol 92:1899-905. 2011
    ..Here, we report that genetically engineered mutants of severe acute respiratory syndrome coronavirus (SARS-CoV) and human coronavirus 229E (HCoV-229E) expressing ADRP-deficient macrodomains ..
  87. pmc Severe acute respiratory syndrome coronavirus envelope protein regulates cell stress response and apoptosis
    Marta L DeDiego
    Department of Molecular and Cell Biology, Centro Nacional de Biotecnologia CNB CSIC, Campus Universidad Autonoma de Madrid, Madrid, Spain
    PLoS Pathog 7:e1002315. 2011
    b>Severe acute respiratory syndrome virus (SARS-CoV) that lacks the envelope (E) gene (rSARS-CoV-ΔE) is attenuated in vivo...
  88. pmc A live attenuated severe acute respiratory syndrome coronavirus is immunogenic and efficacious in golden Syrian hamsters
    Elaine W Lamirande
    Laboratory of Infectious Diseases, NIAID, NIH, Bethesda, MD 20892, USA
    J Virol 82:7721-4. 2008
    The immunogenicity and protective efficacy of a live attenuated vaccine consisting of a recombinant severe acute respiratory syndrome (SARS) coronavirus lacking the E gene (rSARS-CoV-DeltaE) were studied using hamsters...
  89. ncbi Clinical features and short-term outcomes of 144 patients with SARS in the greater Toronto area
    Christopher M Booth
    University of Toronto, Mount Sinai Hospital, Sunnybrook and Women s College Health Sciences Centre, Toronto, Ontario, Canada
    JAMA 289:2801-9. 2003
    b>Severe acute respiratory syndrome (SARS) is an emerging infectious disease that first manifested in humans in China in November 2002 and has subsequently spread worldwide.
  90. pmc Inhibition of NF-κB-mediated inflammation in severe acute respiratory syndrome coronavirus-infected mice increases survival
    Marta L DeDiego
    Department of Molecular and Cell Biology, National Center of Biotechnology, Campus Universidad Autonoma de Madrid, Madrid, Spain
    J Virol 88:913-24. 2014
    b>Severe acute respiratory syndrome coronavirus (SARS-CoV) is the etiological agent of a respiratory disease that has a 10% mortality rate...
  91. pmc SARS outbreak, Taiwan, 2003
    Ying Hen Hsieh
    Departmentof Applied Mathematics, National Chung Hsing University, Taichung, Taiwan
    Emerg Infect Dis 10:201-6. 2004
    We studied the severe acute respiratory syndrome (SARS) outbreak in Taiwan, using the daily case-reporting data from May 5 to June 4 to learn how it had spread so rapidly...
  92. ncbi The Genome sequence of the SARS-associated coronavirus
    Marco A Marra
    British Columbia Cancer Agency BCCA Genome Sciences Centre, 600 West 10th Avenue, Vancouver, British Columbia V5Z 4E6, Canada
    Science 300:1399-404. 2003
    We sequenced the 29,751-base genome of the severe acute respiratory syndrome (SARS)-associated coronavirus known as the Tor2 isolate...
  93. pmc Roadmap to developing a recombinant coronavirus S protein receptor-binding domain vaccine for severe acute respiratory syndrome
    Shibo Jiang
    Lindsley F Kimball Research Institute, New York Blood Center, New York, NY, USA
    Expert Rev Vaccines 11:1405-13. 2012
    A subunit vaccine, RBD-S, is under development to prevent severe acute respiratory syndrome (SARS) caused by SARS coronavirus (SARS-CoV), which is classified by the US NIH as a category C pathogen...
  94. pmc Mechanisms of host receptor adaptation by severe acute respiratory syndrome coronavirus
    Kailang Wu
    Department of Pharmacology, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA
    J Biol Chem 287:8904-11. 2012
    The severe acute respiratory syndrome coronavirus (SARS-CoV) from palm civets has twice evolved the capacity to infect humans by gaining binding affinity for human receptor angiotensin-converting enzyme 2 (ACE2)...
  95. pmc Identification of an antigenic determinant on the S2 domain of the severe acute respiratory syndrome coronavirus spike glycoprotein capable of inducing neutralizing antibodies
    Hong Zhang
    Department of Cell Biology and Genetics, College of Life Sciences, Peking University, Beijing 100871, China
    J Virol 78:6938-45. 2004
    b>Severe acute respiratory syndrome (SARS) is a life-threatening disease caused by a newly identified coronavirus (CoV), SARS-CoV...
  96. pmc Mice susceptible to SARS coronavirus
    David E Wentworth
    New York Department of Health, Albany 12201 2002, USA
    Emerg Infect Dis 10:1293-6. 2004
    Murine models of severe acute respiratory syndrome-associated coronavirus (SARS-CoV) will greatly advance research on this emerging virus...
  97. ncbi SARS corona virus peptides recognized by antibodies in the sera of convalescent cases
    Jian Ping Guo
    Kinsmen Laboratory of Neurological Research, University of British Columbia, Vancouver, BC, Canada V6T 1Z3
    Virology 324:251-6. 2004
    ..membranes 4942 ten-amino-acid peptides which included all of the sequences predicted for the severe acute respiratory syndrome (SARS) corona virus...
  98. ncbi Simulating public health response to a severe acute respiratory syndrome (SARS) event: a comprehensive and systematic approach to designing, implementing, and evaluating a tabletop exercise
    Sue Ann Sarpy
    South Central Center for Public Health Preparedness, and Department of Environmental Health Sciences, Tulane University School of Public Health and Tropical Medicine, 1430 Tulane Avenue, SL 29, New Orleans, LA 70112, USA
    J Public Health Manag Pract . 2005
    ..systems model, a tabletop exercise was developed to simulate worker recognition and response to a Severe Acute Respiratory Syndrome event among public health workers in Arkansas...
  99. ncbi A self-assembled fusion protein-based surface plasmon resonance biosensor for rapid diagnosis of severe acute respiratory syndrome
    Tae Jung Park
    BioProcess Engineering Research Center, Center for Systems and Synthetic Biotechnology, Institute for the BioCentury, KAIST, 335 Gwahangno, Yuseong Gu, Daejeon 305 701, Republic of Korea
    Talanta 79:295-301. 2009
    A surface plasmon resonance (SPR)-based biosensor was developed for simple diagnosis of severe acute respiratory syndrome (SARS) using a protein created by genetically fusing gold binding polypeptides (GBPs) to a SARS coronaviral surface ..
  100. ncbi Epidemiologic study and containment of a nosocomial outbreak of severe acute respiratory syndrome in a medical center in Kaohsiung, Taiwan
    Jien Wei Liu
    Committee of Infection Control and Division of Infectious Diseases, Chang Gung Memorial Hospital, Kaohsiung Medical Center, 123 Ta Pei Road, Niao Sung Hsiang, Kaohsiung Hsien 833, Taiwan
    Infect Control Hosp Epidemiol 27:466-72. 2006
    We conducted an epidemiologic investigation at the beginning of a nosocomial outbreak of severe acute respiratory syndrome (SARS) to clarify the dynamics of SARS transmission, the magnitude of the SARS outbreak, and the impact of the ..
  101. pmc Distinct severe acute respiratory syndrome coronavirus-induced acute lung injury pathways in two different nonhuman primate species
    Saskia L Smits
    Department of Virology, Erasmus Medical Center, P O Box 2040, 3000 CA Rotterdam, Netherlands
    J Virol 85:4234-45. 2011
    ..injury (ALI) and acute respiratory distress syndrome (ARDS), caused by influenza A virus H5N1 and severe acute respiratory syndrome coronavirus (SARS-CoV), supposedly depend on activation of the oxidative-stress machinery that is ..

Research Grants64

  1. SARS-CoV Pathogenic Mechanisms in Senescent Mice
    Ralph S Baric; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) is a zoonotic pathogen that likely emerged from bats, was amplified in civet cats and raccoon dogs and then transmitted to humans causing ..
  2. Mechanisms of viral proteases in coronavirus replication and pathogenesis
    Andrew D Mesecar; Fiscal Year: 2013
    ..mild respiratory disease (croup and common cold like symptoms due to HCoV- NL63, 229e or OC43) to severe acute respiratory syndrome (SARS) outbreaks in humans...
  3. Yeast Based Assays for Chemical Screens Against SARS-CoV Targets
    DANIEL A contact ENGEL; Fiscal Year: 2010
    ..new ways to discover chemical compounds ("drugs") that can be used to study the biology of the Severe Acute Respiratory Syndrome (SARS) coronavirus, called SARS-CoV...
  4. Role of TLR4 in Coronavirus Infection
    Steven M Varga; Fiscal Year: 2010
    ..The emergence of a novel HCoV as the etiologic agent of severe acute respiratory syndrome (SARS) demonstrated the potential of coronaviruses to induce severe respiratory disease and cause a ..
  5. Role of anti-SARS-CoV T cell response in pathogenesis
    Stanley Perlman; Fiscal Year: 2013
    ..This was strikingly illustrated in the 2002-2003 outbreak of the Severe Acute Respiratory Syndrome (SARS), in which >50% of patients who were over 60 year old died while no deaths occurred in ..
  6. Genetic Analysis of Molecular Interactions in Coronavirus Replication
    PAUL SCOTT MASTERS; Fiscal Year: 2013
    ..for common upper respiratory tract infections;a fifth human coronavirus is the causative agent of severe acute respiratory syndrome (SARS), which has the potential to re-emerge into the population from animal reservoirs...
  7. CELLULAR AND MOLECULAR MICROBIOLOGY TRAINING PROGRAM
    JACK J HAWIGER; Fiscal Year: 2010
    ..interactions relevant to biodefense and other microbes that cause human diseases, including Severe Acute Respiratory Syndrome (SARS)...
  8. Modeling viral entry and its inhibition using SARS-CoV
    Graham Simmons; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Severe Acute Respiratory Syndrome-associated Coronavirus (SARS-CoV) is a category C priority pathogen with a high fatality rate that retains the potential to cause a pandemic...
  9. Viral Protein Determinants of Coronavirus Replication Fidelity
    Everett Clinton Smith; Fiscal Year: 2013
    ..RNA viruses that cause respiratory disease in humans ranging in severity from the common cold to severe acute respiratory syndrome (SARS)...
  10. Emerging Infectious Diseases Training Program
    Kathleen A McDonough; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The emergence of Severe Acute Respiratory Syndrome (SARS), potential for a highly pathogenic influenza pandemic, and sobering reality of the 2001 anthrax attacks emphasize the danger to human health ..
  11. XIIth International Nidovirus Symposium Support Proposal
    Udeni Balasuriya; Fiscal Year: 2011
    ..costs, and the recent discovery of a previously unknown coronavirus that is now associated with Severe Acute Respiratory Syndrome (SARS), a newly emerged infectious disease in humans, underpins the importance of scientific ..
  12. Inhibition of the Innate Immune Response by the SARS Coronavirus
    MATTHEW BRYAN FRIEMAN; Fiscal Year: 2010
    b>Severe acute respiratory syndrome (SARS) is a potentially fatal disease that appears to have originated in the Guandong Province of China in the fall of 2002. The disease is caused by a new human coronavirus (CoV), named the SARS-CoV...
  13. Broad spectrum antivirals targeting envelope proteolysis and viral uncoating
    Graham Simmons; Fiscal Year: 2013
    ..Filoviruses, the severe acute respiratory syndrome- coronavirus (Sars-CoV) and the Henipavirus genus of paramyxoviruses are all examples of such agents...
  14. Virus-Like Particle Vaccine for SARS-CoV
    RAPHAEL PAUL VISCIDI; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): A Severe Acute Respiratory Syndrome (SARS) pandemic, caused by re-emergence of the causative coronavirus (CoV) from an animal reservoir, is a serious threat...
  15. UBIQUITIN AND CELLULAR FACTORS IN CORONAVIRUS ASSEMBLY
    THOMAS MILLER GALLAGHER; Fiscal Year: 2010
    ..Coronaviruses cause respiratory diseases in humans and domesticated animals and in cases of severe acute respiratory syndrome coronavirus the symptoms can be life threatening...
  16. PPG: SARS-CoV-host cell interactions and vaccine development
    Stanley Perlman; Fiscal Year: 2013
    Project Summary: The Severe Acute Respiratory Syndrome, caused by a novel coronavlrus (SARS-CoV), resulted in substantial morbidity and mortality in 2002-2003...
  17. A Genetic Analysis of Pneumotropism and Pneumovirulence in an MHV-1 Model of Sars
    Julian L Leibowitz; Fiscal Year: 2010
    The goal of this proposal is to delineate the viral genes that lead to severe acute respiratory syndrome (SARS) utilizing a novel rodent model of SARS. SARS infected over 8,000 persons globally with over 700 deaths...
  18. Flow-enhanced characterization of drug-resistant viruses
    John Yin; Fiscal Year: 2010
    ..to cause diseases such as acquired immunodeficiency syndrome (AIDS), influenza, hepatitis, cancer, severe acute respiratory syndrome (SARS), hemorrhagic fever and the common cold...
  19. Priming and fusion activation of the SARS coronavirus spike glycoprotein
    Gary R Whittaker; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Severe Acute Respiratory Syndrome (SARS) is a recently emerged viral disease caused by a coronavirus (SARS-CoV)...
  20. SARS-CoV Transcription Network Remodeling and the Attenuation of Pathogenesis
    RACHEL LAUREN GRAHAM; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Severe acute respiratory syndrome (SARS) is a lower respiratory disease with approximately 10% mortality that emerged in the Guandong province of China in 2002...
  21. Receptor recognition mechanisms of coronaviruses
    Fang Li; Fiscal Year: 2013
    ..Curiously, ACE2 is also used by group-II SARS coronavirus (SARS-CoV), the agent for the fatal human severe acute respiratory syndrome (SARS)...
  22. RBD recombinant protein-based SARS vaccine for biodefense
    Shibo Jiang; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The 2002-2003 pandemic of severe acute respiratory syndrome (SARS) posed an enormous threat to global public health and the social and economic stability...
  23. Epidemiology and Pathogenesis of Novel Coronaviruses
    SAMUEL RICHARD DOMINGUEZ; Fiscal Year: 2012
    b>Severe acute respiratory syndrome (SARS), caused by a new human coronavirus (SARS-CoV), represents the 21st century's first pandemic caused by a previously unknown etiological agent...
  24. Characterization of the SARSCoV frameshift signal
    Jonathan D Dinman; Fiscal Year: 2010
    ..CoV), and primary sequence analysis of the rapidly emerging SARS-CoV, the etiological agent of Severe Acute Respiratory Syndrome (SARS), reveals the presence of a putative PRF signal that is predicted to shift elongating ..
  25. A novel strategy for developing a SARS-CoV vaccine
    Stanley Perlman; Fiscal Year: 2009
    PROJECT SUMMARY/ABSTRACT Project Summary: The Severe Acute Respiratory Syndrome, caused by a novel coronavirus (SARS-CoV), resulted in substantial morbidity and mortality in 2002-2003...
  26. SARS Coronavirus Virulence Factors and Lung Pathogenesis
    Marc G Wathelet; Fiscal Year: 2010
    The broad long-term objectives of the application are to determine the mechanisms by which the Severe Acute Respiratory Syndrome (SARS)-associated coronavirus (SCoV) causes acute lung injury and to identify new therapeutic strategies...
  27. Antigenic Relationships of SARS and Animal Coronaviruses
    Linda Saif; Fiscal Year: 2006
    b>Severe acute respiratory syndrome (SARS) is a newly emerged global disease of significant economic impact and bioterrorism potential...
  28. Development of antivirals for newly emerging pathogens Ebola and Marburg.
    Matteo Porotto; Fiscal Year: 2013
    ..in intracellular compartments, including orhomyxoviruses (influenza), flaviruses (West Nile virus, Dengue virus), coronaviruses (severe acute respiratory syndrome), arenaviruses (Junin, Lassa), all sharing a similar fusion machinery.
  29. A SARS-CoV Spike Protein Vaccine
    B Sim; Fiscal Year: 2005
    b>Severe acute respiratory syndrome (SARS) has been reported in Asia, North America, and Europe. In March 2003, a novel coronavirus (SARS-CoV) was discovered in association with cases of SARS...
  30. Structure and Mechanism of Programmed Ribosomal Frameshifting in SARS coronavirus
    VICTORIA MANUEL D'SOUZA; Fiscal Year: 2013
    ..by applicant): Coronaviruses (CoV) are associated with severe diseases as demonstrated by the 2003 severe acute respiratory syndrome (SARS)-CoV epidemic...
  31. Porcine Respiratory Coronavirus as a SARS Model
    Linda Saif; Fiscal Year: 2007
    b>Severe acute respiratory syndrome (SARS) is a newly emerging global disease of humans with a major economic impact and significant bioterrorism potential caused by a new strain of coronavirus (CoV)...
  32. EFFECTORS AND IINHIBITORS OF SARS VIRUS POLYMERASE
    Neerja Kaushik Basu; Fiscal Year: 2006
    ..replicase gene 1 of the SARS coronavirus (SARS-CoV), the recently identified causative agent of Severe Acute Respiratory Syndrome (SARS) encompasses nearly two-thirds of its genome (approximately 22 kb) and is predicted to encode ..
  33. Development of a SARS Coronavirus Vaccine
    Jeffrey Ulmer; Fiscal Year: 2004
    b>Severe Acute Respiratory Syndrome (SARS) is an acute infectious pneumonia caused by a new airborne coronavirus (SARS-CoV), which, in an epidemic of only a few months during 2003, affected approximately 8000 people with over 800 deaths...
  34. Role of Coronavirus Membrane Protein Carboxy Tail Virus Assembly
    Ariel L Arndt; Fiscal Year: 2010
    ..Antiviral development against coronaviruses, including the recently emerged severe acute respiratory syndrome coronavirus (SARS-CoV), will provide a significant improvement in health care treatment options...
  35. Development of Alphavirus Replicon Vaccine Against SARS
    Jonathan Smith; Fiscal Year: 2004
    The objective of the proposed research is to develop a safe and effective vaccine for severe acute respiratory syndrome (SARS) using a single-cycle, alphavirus replicon vaccine vector that has been derived from an attenuated strain of ..
  36. International Symposium on Viral Respiratory Disease Surveillance
    Gregory Gray; Fiscal Year: 2009
    ..of notification to the designated national contact, including new subtypes of human influenza and severe acute respiratory syndrome.1,2 IHR 2005 also requires notification of "any event of potential international public health ..
  37. Analysis of the SARS Virus S glycoproteins
    Paul Bates; Fiscal Year: 2005
    b>Severe Acute Respiratory Syndrome (SARS) is a rapidly emerging infectious disease...
  38. SARS Coronavirus Reverse Genetics and Pathogenesis
    PAUL MASTERS; Fiscal Year: 2005
    ..application is to develop and apply this system to the coronavirus that is the causative agent for Severe Acute Respiratory Syndrome (SARS-CoV)...
  39. Synthetic Peptide SARS Coronavirus Diagnostic Kit
    Chang Wang; Fiscal Year: 2005
    The long-term objectives are to develop an enzyme-linked immunoassay (ELISA) for Severe Acute Respiratory Syndrome (SARS), based on synthetic peptide antigens...
  40. Characterizing Class 1 Fusion Proteins: Elucidation of Coronavirus fusion peptide
    IKENNA MADU; Fiscal Year: 2009
    Since the incident of Severe Acute Respiratory Syndrome Corona Virus (SARS-CoV), animal coronaviruses have been thrust into the limelight as important pathogens to study in relation to human disease...
  41. Macaque Model and Gene Expression Profiling of SARS
    Michael Katze; Fiscal Year: 2009
    In the winter of 2002-2003 a new viral pathogen, severe acute respiratory syndrome coronavirus (SARS-CoV), rapidly spread across 5 continents, infected over 8,000 people, and caused 774 deaths...
  42. Modeling U.S. Health Systems' Epidemic Response Capacity
    Nathaniel Hupert; Fiscal Year: 2003
    ..event simulation models of hospital treatment for the six Category A bioterrorist agents and for Severe Acute Respiratory Syndrome. These models will balance hospital bed capacity in each of the 313 U.S...
  43. Development of Proteosome-adjuvanted nasal SARS vaccines
    David Burt; Fiscal Year: 2004
    b>Severe acute respiratory syndrome (SARS), now known to be caused by the SARS coronavirus (SARS-CoV), emerged in China in 2002 and was responsible for more then 8,000 cases of respiratory disease and 774 deaths world-wide...
  44. Rhabdovirus-based recombinant vaccines against SARS
    Bernhard Dietzschold; Fiscal Year: 2006
    Recently an outbreak of atypical pneumonia designated severe acute respiratory syndrome (SARS) caused by a coronavirus (SARS-CoV) emerged first in humans in China and then spread to different countries...
  45. Inflammatory Response and SARS Pathogenesis: An in vitro Model
    CHIEN TE TSENG; Fiscal Year: 2009
    b>Severe acute respiratory syndrome (SARS), caused by a novel coronavirus known as SARS-CoV, is a highly contagious and life-threatening respiratory disease, with the lungs as its main pathological target...
  46. A Centrifugal Microfluidics Based Pathogen Analyzer
    Dalibor Hodko; Fiscal Year: 2006
    Potential threat of biological warfare agent (BWA) attacks as well as spread of SARS (Severe Acute Respiratory Syndrome) virus to more than two dozen countries and a recent threat of global spread of bird flu virus emphasized the need ..
  47. Structure of SARS Coronavirus Spike Glycoprotein
    Michael Root; Fiscal Year: 2005
    b>Severe acute respiratory syndrome (SARS) has recently emerged as a new human disease with a mortality rate as high as 15%...
  48. Development of VLP Vaccines for SARS Prevention
    Richard Compans; Fiscal Year: 2005
    ..particle (VLP)-based immunogens for eliciting strong neutralizing antibody responses against severe acute respiratory syndrome (SARS) coronavirus...
  49. Trial to Reduce Antibiotic Use in A Primary Care PBRN
    David Bates; Fiscal Year: 2004
    ..for inclusion in future trials of therapy in URI care; and providing real-time surveillance for bioterrorist attacks or the emergence of novel respiratory pathogens, such as severe acute respiratory syndrome (SARS).
  50. Rapid NAT System for Point-of-care SARS Diagnosis
    Zihua Wang; Fiscal Year: 2004
    ..of this research application is to develop a rapid, easy to use, integrated nucleic acid test for severe acute respiratory syndrome (SARS) based on our proprietary lab-in-a-tube (Liat TM) platform...
  51. Development of a plant-derived virus-like particle vaccine against SARS-CoV
    BRENDA HOGUE; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Severe acute respiratory syndrome (SARS) is caused by a newly emerged coronavirus...
  52. STRUCTURAL STUDIES OF SARS AND MHV REPLICASE PROTEINS
    L Schultz; Fiscal Year: 2005
    b>Severe Acute Respiratory Syndrome (SARS) has recently emerged as a highly infectious and deadly disease and is caused by a virus that appears to have crossed the species barrier from wild animal to human...
  53. Developing a recombinanat vacine for SARS
    Xuming Zhang; Fiscal Year: 2005
    The current epidemic of the severe acute respiratory syndrome (SARS) is caused by a novel coronavirus, SARS-CoV. To date, the global confirmed SARS cases have reached >8,000 with L800 deaths in 30 countries...
  54. Development of peptide-based vaccine against SARS-CoV
    Gang Liu; Fiscal Year: 2009
    b>Severe acute respiratory syndrome (SARS) caused by coronavirus is an emerging human infectious disease that epidemically spread worldwide...
  55. 2-5A Antisense for Degradation of SARS Coronavirus RNA
    Hagen Cramer; Fiscal Year: 2004
    b>Severe acute respiratory syndrome (SARS) is a newly recognized illness that has rapidly spread throughout Asia, North America and Europe...
  56. Novel Protease Inhibitors as SARS Therapeutics
    Michael Johnson; Fiscal Year: 2009
    ..provided by applicant): The development of new therapeutic drugs against the virus causing Severe Acute Respiratory Syndrome (SARS) is a clear imperative...
  57. SARS-CoV reverse genetics: expression of small ORFs
    Susan Weiss; Fiscal Year: 2006
    Within the last year a new coronavirus (SARS-CoV) has been identified as the etiological agent of severe acute respiratory syndrome (SARS)...
  58. Therapeutic and Diagnostic Antibodies Against SARS
    EILEEN TOZER; Fiscal Year: 2006
    ..is to create antibody reagents that specifically recognize and neutralize the causative agent of severe acute respiratory syndrome, the SARS coronavirus (SARS-CoV)...
  59. Development of a vaccine against SARS-CoV
    Michael Cho; Fiscal Year: 2005
    b>Severe acute respiratory syndrome (SARS), caused by a novel coronavirus SARS-CoV, has been spreading rapidly across the globe...
  60. DEVELOPMENT OF LIGAND ASSISTED ASYMMETRIC SYNTHESES
    Arun Ghosh; Fiscal Year: 2001
    ..Besides the broad range of scope and generality, this line of research will provide excellent opportunities to teach and train graduate and undergraduate students in the laboratory. ..
  61. DESIGN AND SYNTHESIS OF NONPEPTIDE PROTEASE INHIBITORS
    Arun K Ghosh; Fiscal Year: 2010
    ..This research integrates organic synthesis, protein-ligand x-ray crystallography, molecular modeling and in-depth virus and cell-biological studies to design the next generation of HIV-1 protease inhibitors. ..
  62. Anti-HIV-1 Composite Cellulose Acetate Phthalate Film
    Shibo Jiang; Fiscal Year: 2008
    ....
  63. The Role of a Novel Coronavirus In Kawasaki Disease
    Jeffrey Kahn; Fiscal Year: 2007
    ..We have identified a novel human virus, designated the New Haven coronavirus that is associated with KD. The goals of this study is to investigate the role of this novel virus in KD. [unreadable] [unreadable]..
  64. Mentored Patient-Oriented Research Career Development Aw
    Richard Rothman; Fiscal Year: 2004
    ..Findings from this research will provide valuable information that can be used to guide and improve evaluation and management of the growing number of febrile IDUs. ..