pneumonia

Summary

Summary: Inflammation of the lungs.

Top Publications

  1. ncbi CDC definitions for nosocomial infections, 1988
    J S Garner
    Hospital Infections Program, Centers for Disease Control, Atlanta, Georgia
    Am J Infect Control 16:128-40. 1988
  2. doi Global burden of childhood pneumonia and diarrhoea
    Christa L Fischer Walker
    Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Lancet 381:1405-16. 2013
  3. pmc Epidemiology and etiology of childhood pneumonia
    Igor Rudan
    Croatian Centre for Global Health, University of Split Medical School, Split, Croatia
    Bull World Health Organ 86:408-16. 2008
  4. pmc A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17
    Heon Park
    Department of Immunology, University of Washington, Seattle, Washington 98195, USA
    Nat Immunol 6:1133-41. 2005
  5. pmc Pulmonary expression of interleukin-13 causes inflammation, mucus hypersecretion, subepithelial fibrosis, physiologic abnormalities, and eotaxin production
    Z Zhu
    Section of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06520 8057, USA
    J Clin Invest 103:779-88. 1999
  6. pmc Community case management of fever due to malaria and pneumonia in children under five in Zambia: a cluster randomized controlled trial
    Kojo Yeboah-Antwi
    Center for Global Health and Development, Boston University School of Public Health, Boston, Massachusetts, United States of America
    PLoS Med 7:e1000340. 2010
  7. pmc Global estimate of the incidence of clinical pneumonia among children under five years of age
    Igor Rudan
    Department of Medical Stastistics, Epidemiology and Medical Infomatics, School of Public Health Andrija Stampar, Zagreb, Croatia
    Bull World Health Organ 82:895-903. 2004
  8. doi Association of diagnostic coding with trends in hospitalizations and mortality of patients with pneumonia, 2003-2009
    Peter K Lindenauer
    Baystate Medical Center, 280 Chestnut St, Springfield, MA 01199, USA
    JAMA 307:1405-13. 2012
  9. pmc Viral etiology of severe pneumonia among Kenyan infants and children
    James A Berkley
    Kenya Medical Research Institute, Centre for Geographic Medicine Research Coast, Kilifi, Kenya
    JAMA 303:2051-7. 2010
  10. doi Viral infection in patients with severe pneumonia requiring intensive care unit admission
    Sang Ho Choi
    Department of Infectious Diseases, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea
    Am J Respir Crit Care Med 186:325-32. 2012

Detail Information

Publications393 found, 100 shown here

  1. ncbi CDC definitions for nosocomial infections, 1988
    J S Garner
    Hospital Infections Program, Centers for Disease Control, Atlanta, Georgia
    Am J Infect Control 16:128-40. 1988
    ..Other hospitals may wish to adopt or modify them for use in their nosocomial infections surveillance programs...
  2. doi Global burden of childhood pneumonia and diarrhoea
    Christa L Fischer Walker
    Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Lancet 381:1405-16. 2013
    Diarrhoea and pneumonia are the leading infectious causes of childhood morbidity and mortality...
  3. pmc Epidemiology and etiology of childhood pneumonia
    Igor Rudan
    Croatian Centre for Global Health, University of Split Medical School, Split, Croatia
    Bull World Health Organ 86:408-16. 2008
    Childhood pneumonia is the leading single cause of mortality in children aged less than 5 years. The incidence in this age group is estimated to be 0.29 episodes per child-year in developing and 0...
  4. pmc A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17
    Heon Park
    Department of Immunology, University of Washington, Seattle, Washington 98195, USA
    Nat Immunol 6:1133-41. 2005
    ..Thus, IL-17 expression characterizes a unique T helper lineage that regulates tissue inflammation...
  5. pmc Pulmonary expression of interleukin-13 causes inflammation, mucus hypersecretion, subepithelial fibrosis, physiologic abnormalities, and eotaxin production
    Z Zhu
    Section of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06520 8057, USA
    J Clin Invest 103:779-88. 1999
    ..IL-13 may play an important role in the pathogenesis of similar responses in asthma or other Th2-polarized tissue responses...
  6. pmc Community case management of fever due to malaria and pneumonia in children under five in Zambia: a cluster randomized controlled trial
    Kojo Yeboah-Antwi
    Center for Global Health and Development, Boston University School of Public Health, Boston, Massachusetts, United States of America
    PLoS Med 7:e1000340. 2010
    b>Pneumonia and malaria, two of the leading causes of morbidity and mortality among children under five in Zambia, often have overlapping clinical manifestations...
  7. pmc Global estimate of the incidence of clinical pneumonia among children under five years of age
    Igor Rudan
    Department of Medical Stastistics, Epidemiology and Medical Infomatics, School of Public Health Andrija Stampar, Zagreb, Croatia
    Bull World Health Organ 82:895-903. 2004
    Clinical pneumonia (defined as respiratory infections associated with clinical signs of pneumonia, principally pneumonia and bronchiolitis) in children under five years of age is still the leading cause of childhood mortality in the ..
  8. doi Association of diagnostic coding with trends in hospitalizations and mortality of patients with pneumonia, 2003-2009
    Peter K Lindenauer
    Baystate Medical Center, 280 Chestnut St, Springfield, MA 01199, USA
    JAMA 307:1405-13. 2012
    Recent reports suggest that the mortality rate of patients hospitalized with pneumonia has steadily declined...
  9. pmc Viral etiology of severe pneumonia among Kenyan infants and children
    James A Berkley
    Kenya Medical Research Institute, Centre for Geographic Medicine Research Coast, Kilifi, Kenya
    JAMA 303:2051-7. 2010
    b>Pneumonia is the leading cause of childhood death in sub-Saharan Africa. Comparative estimates of the contribution of causative pathogens to the burden of disease are essential for targeted vaccine development.
  10. doi Viral infection in patients with severe pneumonia requiring intensive care unit admission
    Sang Ho Choi
    Department of Infectious Diseases, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea
    Am J Respir Crit Care Med 186:325-32. 2012
    The role of viruses in pneumonia in adults and the impact of viral infection on mortality have not been elucidated. Previous studies have significant limitations in that they relied predominantly on upper respiratory specimens.
  11. doi Interventions to address deaths from childhood pneumonia and diarrhoea equitably: what works and at what cost?
    Zulfiqar A Bhutta
    Division of Woman and Child Health, Aga Khan University, Karachi, Pakistan
    Lancet 381:1417-29. 2013
    ..b>Pneumonia and diarrhoea are the two leading causes of death in this age group and have overlapping risk factors...
  12. ncbi Community-acquired pneumonia
    E Polverino
    Pneumology Department, Clinic Institute of Thorax ICT, Hospital Clinic of Barcelona, August Pi i Sunyer IDIBAPS Biomedical Investigation Institute, Barcelona, Spain
    Minerva Anestesiol 77:196-211. 2011
    ..advances in antibiotic therapies, diagnostic tools, prevention campaigns and intensive care, community-acquired pneumonia (CAP) is still among the primary causes of death worldwide, and there have been no significant changes in ..
  13. doi U.S. hospitalizations for pneumonia after a decade of pneumococcal vaccination
    Marie R Griffin
    Department of Preventive Medicine, Vanderbilt University School of Medicine, Nashville, TN 37212, USA
    N Engl J Med 369:155-63. 2013
    ..By 2004, hospitalizations associated with pneumonia from any cause had also declined markedly among young children...
  14. ncbi Childhood pneumonia and diarrhoea: setting our priorities right
    Igor Rudan
    Child Health and Nutrition Research Initiative, Global Forum for Health Research, Geneva, Switzerland
    Lancet Infect Dis 7:56-61. 2007
    Childhood pneumonia and diarrhoeal disease cause almost half of all child deaths globally. Effective interventions against these conditions are available and could prevent about two-thirds of these deaths...
  15. pmc Acute kidney injury in non-severe pneumonia is associated with an increased immune response and lower survival
    Raghavan Murugan
    The CRISMA Laboratory, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    Kidney Int 77:527-35. 2010
    ..associated with acute kidney injury in 1836 hospitalized patients with community-acquired severe and non-severe pneumonia. Acute kidney injury developed in 631 patients of whom 329 had severe and 302 had non-severe sepsis...
  16. pmc IL-6 is an antiinflammatory cytokine required for controlling local or systemic acute inflammatory responses
    Z Xing
    Immunology and Infection Program, Department of Pathology, McMaster University, Hamilton, Ontario, L8N 3Z5 Canada
    J Clin Invest 101:311-20. 1998
    ....
  17. ncbi Inhaled corticosteroid use in chronic obstructive pulmonary disease and the risk of hospitalization for pneumonia
    Pierre Ernst
    Pharmacoepidemiology Research Unit, Department of Medicine, McGill University Health Centre, and Division of Clinical Epidemiology, Ross 4 29, Royal Victoria Hospital, 687 Pine Avenue West, Montreal, PQ, Quebec, H3A 1A1 Canada
    Am J Respir Crit Care Med 176:162-6. 2007
    ..Inhaled corticosteroids are commonly prescribed to patients with chronic obstructive pulmonary disease (COPD)...
  18. pmc Standardized interpretation of paediatric chest radiographs for the diagnosis of pneumonia in epidemiological studies
    Thomas Cherian
    Initiative for Vaccine Research, Department of Immunization, Vaccines and Biologicals, World Health Organization, 1211 Geneva 27, Switzerland
    Bull World Health Organ 83:353-9. 2005
    Although radiological pneumonia is used as an outcome measure in epidemiological studies, there is considerable variability in the interpretation of chest radiographs...
  19. pmc Diagnoses and timing of 30-day readmissions after hospitalization for heart failure, acute myocardial infarction, or pneumonia
    Kumar Dharmarajan
    Division of Cardiology, Department of Internal Medicine, Columbia University Medical Center, New York, New York, USA
    JAMA 309:355-63. 2013
    ..rates of 30-day readmission after hospitalization for heart failure (HF), acute myocardial infarction (MI), or pneumonia, further information is needed about readmission diagnoses, readmission timing, and the relationship of both to ..
  20. doi Etiology of community-acquired pneumonia: increased microbiological yield with new diagnostic methods
    Niclas Johansson
    Department of Medicine, Karolinska Institutet, Stockholm, Sweden
    Clin Infect Dis 50:202-9. 2010
    The microbial etiology of community-acquired pneumonia (CAP) is still not well characterized...
  21. ncbi Cigarette smoke-induced pulmonary inflammation is TLR4/MyD88 and IL-1R1/MyD88 signaling dependent
    Emilie Doz
    University of Orleans and Centre National de la Recherche Scientifique UMR6218, Molecular Immunology and Embryology, France
    J Immunol 180:1169-78. 2008
    ....
  22. pmc Indoor air pollution in developing countries and acute lower respiratory infections in children
    K R Smith
    Environmental Health Sciences, University of California, Berkeley 94720 7360, USA
    Thorax 55:518-32. 2000
    ..infections in young children, which is focused on, but not confined to, acute lower respiratory infection and pneumonia in children under two years in less developed countries...
  23. doi Mouse pulmonary dose- and time course-responses induced by exposure to multi-walled carbon nanotubes
    Dale W Porter
    National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA
    Toxicology 269:136-47. 2010
    ..Furthermore, the observation that MWCNT reach the pleura after aspiration exposure indicates that more extensive investigations are needed to fully assess if pleural penetration results in any adverse health outcomes...
  24. pmc Acute lower respiratory tract infection
    Joseph P Mizgerd
    Molecular and Integrative Physiological Sciences Program, Harvard School of Public Health, Boston, MA 02115, USA
    N Engl J Med 358:716-27. 2008
  25. pmc Pneumonia and pneumonia related mortality in patients with COPD treated with fixed combinations of inhaled corticosteroid and long acting β2 agonist: observational matched cohort study (PATHOS)
    Christer Janson
    Department of Medical Sciences, Respiratory Medicine, Uppsala University, Uppsala, Sweden
    BMJ 346:f3306. 2013
    To investigate the occurrence of pneumonia and pneumonia related events in patients with chronic obstructive pulmonary disease (COPD) treated with two different fixed combinations of inhaled corticosteroid/long acting β2 agonist.
  26. doi Pneumonia risk in COPD patients receiving inhaled corticosteroids alone or in combination: TORCH study results
    C Crim
    GlaxoSmithKline, Research Triangle Park, NC 27709 3398, USA
    Eur Respir J 34:641-7. 2009
    ..in COPD Health (TORCH) study, we analysed and identified potential risk factors for adverse event reports of pneumonia in this randomised, double-blind trial comparing twice-daily inhaled salmeterol (SAL) 50 microg, fluticasone ..
  27. pmc Novel structurally designed vaccine for S. aureus α-hemolysin: protection against bacteremia and pneumonia
    Rajan P Adhikari
    Integrated Biotherapeutics Inc, Gaithersburg, Maryland, United States of America
    PLoS ONE 7:e38567. 2012
    ..is a human pathogen associated with skin and soft tissue infections (SSTI) and life threatening sepsis and pneumonia. Efforts to develop effective vaccines against S...
  28. ncbi Soluble triggering receptor expressed on myeloid cells and the diagnosis of pneumonia
    Sebastien Gibot
    Service de Reanimation Medicale, Hopital Central, Nancy, France
    N Engl J Med 350:451-8. 2004
    The diagnosis and treatment of bacterial pneumonia in patients who are receiving mechanical ventilation remain a difficult challenge...
  29. doi Understanding careseeking for child illness in sub-Saharan Africa: a systematic review and conceptual framework based on qualitative research of household recognition and response to child diarrhoea, pneumonia and malaria
    Christopher J Colvin
    Centre for Infectious Disease Epidemiology and Research, Falmouth 5 49, School of Public Health and Family Medicine, University of Cape Town, Observatory 7925, Cape Town, South Africa
    Soc Sci Med 86:66-78. 2013
    Diarrhoea, pneumonia and malaria are the largest contributors to childhood mortality in sub-Saharan Africa...
  30. pmc Comparative effects of inhaled diesel exhaust and ambient fine particles on inflammation, atherosclerosis, and vascular dysfunction
    Chunli Quan
    Department of Environmental Medicine, New York University School of Medicine, Tuxedo, New York 10987, USA
    Inhal Toxicol 22:738-53. 2010
    ....
  31. doi Reported pneumonia in patients with COPD: findings from the INSPIRE study
    Peter M A Calverley
    Clinical Science Centre, University Hospital Aintree, Longmoor Lane, Liverpool L9 7AL, England
    Chest 139:505-12. 2011
    b>Pneumonia is an important complication of COPD and is reported more often in patients receiving inhaled corticosteroids (ICSs). Little is known about the clinical course and factors predisposing to pneumonia in patients with COPD...
  32. pmc Diabetes, glycemic control, and risk of hospitalization with pneumonia: a population-based case-control study
    Jette B Kornum
    Department of Clinical Epidemiology, Aarhus University Hospital, Aalborg, Denmark
    Diabetes Care 31:1541-5. 2008
    To examine whether diabetes is a risk factor for hospitalization with pneumonia and to assess the impact of A1C level on such risk.
  33. pmc The effect of case management on childhood pneumonia mortality in developing countries
    Evropi Theodoratou
    Public Health Sciences, University of Edinburgh, Edinburgh, UK
    Int J Epidemiol 39:i155-71. 2010
    ..the Lives Saved Tool (LiST) with parameters of effectiveness of existing interventions, we conducted a systematic review of the literature assessing the effect of pneumonia case management on mortality from childhood pneumonia.
  34. pmc Community case management of pneumonia: at a tipping point?
    David R Marsh
    Save the Children USA, Amherst, MA, USA
    Bull World Health Organ 86:381-9. 2008
    b>Pneumonia is the leading cause of child mortality globally...
  35. doi Effect of reduction in household air pollution on childhood pneumonia in Guatemala (RESPIRE): a randomised controlled trial
    Kirk R Smith
    Environmental Health Sciences, School of Public Health, University of California, Berkeley, CA 94720 7360, USA
    Lancet 378:1717-26. 2011
    b>Pneumonia causes more child deaths than does any other disease. Observational studies have indicated that smoke from household solid fuel is a significant risk factor that affects about half the world's children...
  36. pmc Incidence, seasonality and mortality associated with influenza pneumonia in Thailand: 2005-2008
    James Mark Simmerman
    International Emerging Infections Program, Thailand Ministry of Public Health United States Centers for Disease Control Collaboration, Nonthaburi, Thailand
    PLoS ONE 4:e7776. 2009
    ..Prospective data from multiple years are needed to develop vaccine policy and treatment guidelines, and improve pandemic preparedness...
  37. ncbi A review of carbon nanotube toxicity and assessment of potential occupational and environmental health risks
    Chiu wing Lam
    JSC Toxicology Group, Space Life Sciences, NASA Johnson Space Center, Wyle Laboratories and Department of Pathology and Laboratory Medicine, University of Texas Medical School, Houston, Texas 77058, USA
    Crit Rev Toxicol 36:189-217. 2006
    ..Therefore, CNTs from manufactured and combustion sources in the environment could have adverse effects on human health...
  38. doi Long-term use of inhaled corticosteroids and the risk of pneumonia in chronic obstructive pulmonary disease: a meta-analysis
    Sonal Singh
    Department of Medicine, Wake Forest University School of Medicine, One Medical Center Boulevard, Winston Salem, NC 27157, USA
    Arch Intern Med 169:219-29. 2009
    Recent studies have suggested a possible association between pneumonia and the use of inhaled corticosteroids...
  39. doi Blocking IL-17A promotes the resolution of pulmonary inflammation and fibrosis via TGF-beta1-dependent and -independent mechanisms
    Su Mi
    Molecular Immunology and Pharmacology Laboratory, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, People s Republic of China
    J Immunol 187:3003-14. 2011
    ....
  40. doi Uric acid is a danger signal activating NALP3 inflammasome in lung injury inflammation and fibrosis
    Pamela Gasse
    University of Orleans and CNRS, Orleans, France
    Am J Respir Crit Care Med 179:903-13. 2009
    ..The molecular mechanisms by which lung injury triggers IL-1beta production, inflammation, and fibrosis remain poorly understood...
  41. pmc Contrasting effects of CCR5 and CCR2 deficiency in the pulmonary inflammatory response to influenza A virus
    T C Dawson
    Department of Pathology and Laboratory Medicine, University of North Carolina School of Medicine, Chapel Hill, NC 27599 7525, USA
    Am J Pathol 156:1951-9. 2000
    ....
  42. pmc Pathological versus protective functions of IL-22 in airway inflammation are regulated by IL-17A
    Gregory F Sonnenberg
    Department of Pathobiology, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Exp Med 207:1293-305. 2010
    ....
  43. ncbi Air pollution and hospital admissions for pneumonia in a subtropical city: Taipei, Taiwan
    Hui Feng Chiu
    Institute of Pharmacology, College of Medicine, Kaohsiung Medical University, 100 Shih Chuan 1st Road, Kaohsiung, Taiwan
    Inhal Toxicol 21:32-7. 2009
    ..to determine whether there was an association between air pollutant levels and hospital admissions for pneumonia in Taipei, Taiwan...
  44. pmc IL-1R1/MyD88 signaling and the inflammasome are essential in pulmonary inflammation and fibrosis in mice
    Pamela Gasse
    Laboratory of Molecular Immunology and Embryology, University of Orleans and CNRS, Orleans, France
    J Clin Invest 117:3786-99. 2007
    ..In conclusion, bleomycin-induced lung pathology required the inflammasome and IL-1R1/MyD88 signaling, and IL-1 represented a critical effector of pathology and therapeutic target of chronic lung inflammation and fibrosis...
  45. doi Respiratory viruses in adults with community-acquired pneumonia
    David Lieberman
    Pulmonary Unit, Soroka Medical Center, Beer Sheva, Israel
    Chest 138:811-6. 2010
    ..has increased the identification of respiratory viruses (RVs) in adult patients with community-acquired pneumonia (CAP)...
  46. ncbi Risk of community-acquired pneumonia and use of gastric acid-suppressive drugs
    Robert J F Laheij
    Department of Gastroenterology, University Medical Center St Radboud, Nijmegen, The Netherlands
    JAMA 292:1955-60. 2004
    ..Reduction of gastric acid secretion by acid-suppressive therapy allows pathogen colonization from the upper gastrointestinal tract. The bacteria and viruses in the contaminated stomach have been identified as species from the oral cavity...
  47. pmc Serum glucose levels for predicting death in patients admitted to hospital for community acquired pneumonia: prospective cohort study
    Philipp M Lepper
    Department of Internal Medicine V, University Hospital of Saarland, D 66421, Homburg, Germany
    BMJ 344:e3397. 2012
    To examine whether acute dysglycaemia predicts death in people admitted to hospital with community acquired pneumonia.
  48. pmc Inhaled corticosteroids in COPD and the risk of serious pneumonia
    Samy Suissa
    Departments of Epidemiology and Biostatistics and of Medicine, Center for Clinical Epidemiology, Lady Davis Research Institute, Jewish General Hospital, McGill University, Montreal, Quebec, Canada
    Thorax 68:1029-36. 2013
    Inhaled corticosteroids (ICS) are known to increase the risk of pneumonia in patients with chronic obstructive pulmonary disease (COPD)...
  49. pmc An administrative claims model for profiling hospital 30-day mortality rates for pneumonia patients
    Dale W Bratzler
    Oklahoma Foundation for Medical Quality, Oklahoma City, Oklahoma, United States of America
    PLoS ONE 6:e17401. 2011
    Outcome measures for patients hospitalized with pneumonia may complement process measures in characterizing quality of care...
  50. pmc Use of acid-suppressive drugs and risk of pneumonia: a systematic review and meta-analysis
    Chun Sick Eom
    Department of Family Medicine, Seoul National University Hospital, Seoul, Republic of Korea
    CMAJ 183:310-9. 2011
    ..randomized controlled trials have yielded inconsistent findings about the association between the use of acid-suppressive drugs and the risk of pneumonia. We performed a systematic review and meta-analysis to summarize this association.
  51. doi Novel murine model of chronic granulomatous lung inflammation elicited by carbon nanotubes
    Isham Huizar
    Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Internal Medicine, Brody School of Medicine, East Carolina University, 3E 149 Brody Medical Sciences Building, Greenville, NC 27834, USA
    Am J Respir Cell Mol Biol 45:858-66. 2011
    ..The establishment of such a model provides an important platform for mechanistic studies on the persistence of granuloma...
  52. pmc Effect of case management on neonatal mortality due to sepsis and pneumonia
    Anita K M Zaidi
    Department of Paediatrics and Child Health, The Aga Khan University, Karachi, Pakistan
    BMC Public Health 11:S13. 2011
    ..We have estimated the effect of providing oral, or injectable antibiotics at home or in first-level facilities, and of in-patient hospital care on neonatal mortality from pneumonia and sepsis for use in the Lives Saved Tool (LiST).
  53. pmc Community case management of severe pneumonia with oral amoxicillin in children aged 2-59 months in Haripur district, Pakistan: a cluster randomised trial
    Abdul Bari
    Save the Children US, Pakistan Country Office, Islamabad, Pakistan
    Lancet 378:1796-803. 2011
    First dose oral co-trimoxazole and referral are recommended for WHO-defined severe pneumonia. Difficulties with referral compliance are reported in many low-resource settings, resulting in low access to appropriate treatment...
  54. ncbi Effect of pneumonia case management on mortality in neonates, infants, and preschool children: a meta-analysis of community-based trials
    Sunil Sazawal
    Department of International Health, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Lancet Infect Dis 3:547-56. 2003
    b>Pneumonia still causes around two million deaths among children annually (20% of all child deaths). Any intervention that would affect pneumonia mortality is of great public health importance...
  55. doi Dexamethasone and length of hospital stay in patients with community-acquired pneumonia: a randomised, double-blind, placebo-controlled trial
    Sabine C A Meijvis
    Department of Internal Medicine, St Antonius Hospital, Nieuwegein, Netherlands
    Lancet 377:2023-30. 2011
    Whether addition of corticosteroids to antibiotic treatment benefits patients with community-acquired pneumonia who are not in intensive care units is unclear...
  56. doi Severity assessment tools for predicting mortality in hospitalised patients with community-acquired pneumonia. Systematic review and meta-analysis
    James D Chalmers
    University of Edinburgh, Edinburgh, UK
    Thorax 65:878-83. 2010
    International guidelines recommend a severity-based approach to management in community-acquired pneumonia. CURB65, CRB65 and the Pneumonia Severity Index (PSI) are the most widely recommended severity scores...
  57. pmc The Pneumonia Etiology Research for Child Health Project: a 21st century childhood pneumonia etiology study
    Orin S Levine
    Department of International Health, International Vaccine Access Center, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21205, USA
    Clin Infect Dis 54:S93-101. 2012
    The Pneumonia Etiology Research for Child Health (PERCH) project is a 7-country, standardized, comprehensive evaluation of the etiologic agents causing severe pneumonia in children from developing countries...
  58. doi Efficacy of corticosteroids in community-acquired pneumonia: a randomized double-blinded clinical trial
    Dominic Snijders
    Department of Pulmonary Diseases, Medical Centre Alkmaar, Wilhelminalaan 15, 1812 JD Alkmaar, The Netherlands
    Am J Respir Crit Care Med 181:975-82. 2010
    Some studies have shown a beneficial effect of corticosteroids in patients with community-acquired pneumonia (CAP), possibly by diminishing local and systemic antiinflammatory host response.
  59. ncbi Unusual inflammatory and fibrogenic pulmonary responses to single-walled carbon nanotubes in mice
    Anna A Shvedova
    Health Effects Laboratory Div, NIOSH, Morgantown, WV, USA
    Am J Physiol Lung Cell Mol Physiol 289:L698-708. 2005
    ..Equal doses of ultrafine carbon black particles or fine crystalline silica (SiO2) did not induce granulomas or alveolar wall thickening and caused a significantly weaker pulmonary inflammation and damage...
  60. doi British Thoracic Society guidelines for the management of community acquired pneumonia in children: update 2011
    Michael Harris
    Oxford Children s Hospital, The John Radcliffe, Headington, Oxford, UK
    Thorax 66:ii1-23. 2011
    The British Thoracic Society first published management guidelines for community acquired pneumonia in children in 2002 and covered available evidence to early 2000...
  61. doi Pneumonia in severely malnourished children in developing countries - mortality risk, aetiology and validity of WHO clinical signs: a systematic review
    Mohammod Jobayer Chisti
    Clinical Science Division, International Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh
    Trop Med Int Health 14:1173-89. 2009
    To quantify the degree by which moderate and severe degrees of malnutrition increase the mortality risk in pneumonia, to identify potential differences in the aetiology of pneumonia between children with and without severe malnutrition, ..
  62. ncbi Pulmonary adenoma susceptibility 1 (Pas1) locus affects inflammatory response
    Durvanei Augusto Maria
    Laboratorio de Immunogenetica, Instituto Butantan, Sao Paulo, Brazil
    Oncogene 22:426-32. 2003
    ..These results provide a model to explore the mechanism underlying inherited predisposition to lung cancer in the context of a link to inflammation...
  63. pmc Stroke-induced immunodeficiency promotes spontaneous bacterial infections and is mediated by sympathetic activation reversal by poststroke T helper cell type 1-like immunostimulation
    Konstantin Prass
    Department of Experimental Neurology, Charite Hospital, Humboldt University, Schumannstrasse 20 21, D 10098 Berlin, Germany
    J Exp Med 198:725-36. 2003
    ..3 d after ischemia, all animals developed spontaneous septicemia and pneumonia. Stroke induced an extensive apoptotic loss of lymphocytes and a shift from T helper cell (Th)1 to Th2 cytokine ..
  64. ncbi Severe sepsis in community-acquired pneumonia: when does it happen, and do systemic inflammatory response syndrome criteria help predict course?
    Tony Dremsizov
    606 Scaife Hall, The CRISMA Laboratory, Critical Care Medicine, University of Pittsburgh, 3550 Terrace St, Pittsburgh, PA 15261
    Chest 129:968-78. 2006
    ..onset and timing of severe sepsis during the hospital course for patients hospitalized with community-acquired pneumonia (CAP)...
  65. pmc The anti-inflammatory and proresolving mediator resolvin E1 protects mice from bacterial pneumonia and acute lung injury
    Hiroyuki Seki
    Department of Anesthesiology, Keio University School of Medicine, Tokyo, Japan
    J Immunol 184:836-43. 2010
    Whereas pneumonia is the most common cause of death and disability worldwide, most cases of pneumonia spontaneously resolve. Mechanisms that promote pneumonia resolution remain to be determined...
  66. doi Tidal volume lower than 6 ml/kg enhances lung protection: role of extracorporeal carbon dioxide removal
    Pier Paolo Terragni
    Dipartimento di Anestesiologia e Medicina degli Stati Critici, Universita di Torino, Ospedale S Giovanni Battista Molinette, Corso Dogliotti 14, Turin, Italy
    Anesthesiology 111:826-35. 2009
    ..The authors verified whether VT lower than 6 ml/kg may enhance lung protection and that consequent respiratory acidosis may be managed by extracorporeal carbon dioxide removal...
  67. doi Impact of trough IgG on pneumonia incidence in primary immunodeficiency: A meta-analysis of clinical studies
    Jordan S Orange
    Division of Allergy and Immunology, Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Clin Immunol 137:21-30. 2010
    ..To address this question, all available studies evaluating trough IgG and pneumonia incidence in PIDD patients with hypogammaglobulinemia receiving IVIG were quantitatively combined by meta-..
  68. doi Pneumonia caused by methicillin-resistant Staphylococcus aureus
    Ethan Rubinstein
    University of Manitoba, Winnipeg, Canada
    Clin Infect Dis 46:S378-85. 2008
    ..support of an aging, often chronically ill population, has resulted in a large increase in cases of MRSA pneumonia in the health care setting. In addition, community-acquired MRSA pneumonia has become more prevalent...
  69. ncbi Clinical and economic consequences of ventilator-associated pneumonia: a systematic review
    Nasia Safdar
    Section of Infectious Diseases, Department of Medicine, University of Wisconsin Medical School, 600 Highland Avenue, Madison, WI 53792, USA
    Crit Care Med 33:2184-93. 2005
    Ventilator-associated pneumonia (VAP) is the most common nosocomial infection in critically ill patients. The clinical and economic consequences of VAP are unclear, with a broad range of values reported in the literature
  70. doi Can lay community health workers be trained to use diagnostics to distinguish and treat malaria and pneumonia in children? Lessons from rural Uganda
    D Mukanga
    Department of Epidemiology and Biostatistics, Makerere University School of Public Health, Kampala, Uganda
    Trop Med Int Health 16:1234-42. 2011
    To determine the competence of community health workers (CHWs) to correctly assess, classify and treat malaria and pneumonia among under-five children after training.
  71. pmc New perspectives on community-acquired pneumonia in 388 406 patients. Results from a nationwide mandatory performance measurement programme in healthcare quality
    S Ewig
    Thoraxzentrum Ruhrgebiet, Kliniken für Pneumologie und Infektiologie, Herne und Bochum, Germany
    Thorax 64:1062-9. 2009
    The database of the German programme for quality in healthcare including data of every hospitalised patient with community-acquired pneumonia (CAP) during a 2-year period (n = 388 406 patients in 2005 and 2006) was analysed.
  72. ncbi Undernutrition as an underlying cause of child deaths associated with diarrhea, pneumonia, malaria, and measles
    Laura E Caulfield
    Department of International Health, The Johns Hopkins University, Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Am J Clin Nutr 80:193-8. 2004
    ..Previous analyses derived the relative risk (RR) of dying as a result of low weight-for-age and calculated the proportion of child deaths worldwide attributable to underweight...
  73. ncbi U.K. Controlled trial of intrapleural streptokinase for pleural infection
    Nicholas A Maskell
    Oxford Centre for Respiratory Medicine, Churchill Hospital Site, Oxford Radcliffe Hospital, Headington, Oxford, United Kingdom
    N Engl J Med 352:865-74. 2005
    ..This use is based on small trials that did not have the statistical power to evaluate accurately important clinical outcomes, including safety. We conducted a trial to clarify the therapeutic role of intrapleural streptokinase...
  74. pmc Lung epithelial apoptosis in influenza virus pneumonia: the role of macrophage-expressed TNF-related apoptosis-inducing ligand
    Susanne Herold
    University of Giessen Lung Center, Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine and Infectious Diseases, Justus Liebig University, Giessen, Germany
    J Exp Med 205:3065-77. 2008
    ..of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) in a murine model of influenza-induced pneumonia. Using CC-chemokine receptor 2-deficient (CCR2(-/-)) mice characterized by defective inflammatory macrophage ..
  75. ncbi The relation between hyperglycemia and outcomes in 2,471 patients admitted to the hospital with community-acquired pneumonia
    Finlay A McAlister
    2E3 24 WMC, University of Alberta Hospital, 8440 112 Street, Edmonton, Alberta, Canada T6G 2R7
    Diabetes Care 28:810-5. 2005
    To examine whether hyperglycemia at the time of presentation was associated with outcomes in patients admitted to non-intensive care settings with community-acquired pneumonia (CAP).
  76. doi Recurrent community-acquired pneumonia in patients starting acid-suppressing drugs
    Dean T Eurich
    Department of Public Health Sciences, School of Public Health, University of Alberta, Edmonton, Alberta, Canada
    Am J Med 123:47-53. 2010
    ..proton pump inhibitors (PPIs) and histamine 2-receptor antagonists (H2s) increase risk of community-acquired pneumonia. To test this hypothesis, we examined a prospective population-based cohort predisposed to pneumonia: elderly ..
  77. doi Community-acquired pneumonia as an emergency: time for an aggressive intervention to lower mortality
    S Ewig
    Thoraxzentrum Ruhrgebiet, Kliniken für Pneumologie und Infektiologie, Evangelisches Krankenhaus Herne und Augusta Kranken Anstalt Bochum, Bergstrasse 26, 44791 Bochum, Germany
    Eur Respir J 38:253-60. 2011
    Community-acquired pneumonia (CAP) is one of the major contemporary acute life-threatening conditions...
  78. doi The impact of benzodiazepines on occurrence of pneumonia and mortality from pneumonia: a nested case-control and survival analysis in a population-based cohort
    Eneanya Obiora
    Division of Epidemiology and Public Health, University of Nottingham, Nottingham, UK
    Thorax 68:163-70. 2013
    ..Here, we determined the effect of community use of benzodiazepines on the occurrence of, and mortality following, pneumonia.
  79. pmc Relationship between hospital readmission and mortality rates for patients hospitalized with acute myocardial infarction, heart failure, or pneumonia
    Harlan M Krumholz
    Department of Internal Medicine Section of Cardiovascular Medicine, Yale University School of Medicine, 1 Church St, Ste 200, New Haven, CT 06510, USA
    JAMA 309:587-93. 2013
    ..and 30-day, all-cause, risk-standardized readmission rates (RSRRs) for acute myocardial infarction, heart failure, and pneumonia. The evaluation of hospital performance as measured by RSMRs and RSRRs has not been well characterized.
  80. pmc Outpatient treatment of children with severe pneumonia with oral amoxicillin in four countries: the MASS study
    Emmanuel Addo-Yobo
    Komfo Anokye Teaching Hospital, University of Science and Technology, Kumasi, Ghana
    Trop Med Int Health 16:995-1006. 2011
    A recent randomized clinical trial demonstrated home-based treatment of WHO-defined severe pneumonia with oral amoxicillin was equivalent to hospital-based therapy and parenteral antibiotics...
  81. pmc Impact of social factors on risk of readmission or mortality in pneumonia and heart failure: systematic review
    Linda Calvillo-King
    Division of General Internal Medicine, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 8889, USA
    J Gen Intern Med 28:269-82. 2013
    Readmission and mortality after hospitalization for community-acquired pneumonia (CAP) and heart failure (HF) are publically reported...
  82. ncbi Time to clinical stability in patients hospitalized with community-acquired pneumonia: implications for practice guidelines
    E A Halm
    Department of Health Policy, Mount Sinai School of Medicine, New York, NY 10029, USA
    JAMA 279:1452-7. 1998
    Many groups have developed guidelines to shorten hospital length of stay in pneumonia in order to decrease costs, but the length of time until a patient hospitalized with pneumonia becomes clinically stable has not been established.
  83. pmc Prevalence of herpes and respiratory viruses in induced sputum among hospitalized children with non typical bacterial community-acquired pneumonia
    Weimin Zhou
    Key Laboratory of Medical Virology, Ministry of Health National Institute for Viral Disease Control and Prevention, China CDC, Beijing, China
    PLoS ONE 8:e79477. 2013
    Few comprehensive studies have searched for viruses in infants and young children with community-acquired pneumonia (CAP) in China...
  84. ncbi Development of a clinical score (A2DS2) to predict pneumonia in acute ischemic stroke
    Sarah Hoffmann
    Centre for Stroke Research Berlin, Charite Universitatsmedizin, Berlin, Germany
    Stroke 43:2617-23. 2012
    Poststroke pneumonia is a potentially preventable complication after stroke associated with poor outcome. We developed and externally validated a prognostic score for predicting risk of pneumonia after ischemic stroke.
  85. doi Cardiac complications in patients with community-acquired pneumonia: incidence, timing, risk factors, and association with short-term mortality
    Vicente F Corrales-Medina
    Ottawa Hospital Research Institute, Ottawa, Ontario, Canada
    Circulation 125:773-81. 2012
    Community-acquired pneumonia (CAP) affects >5 million adults each year in the United States...
  86. ncbi Effect of age, polymicrobial disease, and maternal HIV status on treatment response and cause of severe pneumonia in South African children: a prospective descriptive study
    Lisa M McNally
    Centre for International Child Health and Development, Institute of Child Health, University College London, London WC1N 1EH, UK
    Lancet 369:1440-51. 2007
    HIV-related pneumonia is the main cause of paediatric hospital admissions in southern Africa...
  87. pmc Risk factors for community-acquired pneumonia in adults in Europe: a literature review
    Antoni Torres
    Servei de Pneumologia, Hospital Clinic de Barcelona, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, Ciber de enfermedades respiratorias CIBERES, University of Barcelona, Barcelona, Spain
    Thorax 68:1057-65. 2013
    Community-acquired pneumonia (CAP) causes considerable morbidity and mortality in adults, particularly in the elderly.
  88. doi Effectiveness of community case management of severe pneumonia with oral amoxicillin in children aged 2-59 months in Matiari district, rural Pakistan: a cluster-randomised controlled trial
    Sajid Soofi
    Division of Women and Child Health, Aga Khan University, Karachi, Pakistan
    Lancet 379:729-37. 2012
    b>Pneumonia is a leading global cause of morbidity and mortality in children younger than 5 years...
  89. doi Obesity and risk of subsequent hospitalisation with pneumonia
    J B Kornum
    Dept of Clinical Epidemiology, Aarhus University Hospital, Denmark
    Eur Respir J 36:1330-6. 2010
    Obesity may be associated with increased risk of pneumonia, but available data on this relationship are sparse and inconsistent...
  90. pmc Healthcare-seeking behaviour for common infectious disease-related illnesses in rural Kenya: a community-based house-to-house survey
    Deron C Burton
    Centers for Disease Control and Prevention, 1600 Clifton Road NE, Atlanta, GA 30333, USA
    J Health Popul Nutr 29:61-70. 2011
    ..Healthcare sought for acute episodes of diarrhoea or fever in the past two weeks or pneumonia in the past year was evaluated...
  91. doi Therapeutic potential of bacteriophage in treating Klebsiella pneumoniae B5055-mediated lobar pneumonia in mice
    Sanjay Chhibber
    Department of Microbiology, Panjab University, Chandigarh 160014, India
    J Med Microbiol 57:1508-13. 2008
    ..pneumoniae-mediated lobar pneumonia in mice. Mice were challenged by intranasal (i.n.) inoculation with bacteria (10(8) c.f.u. ml(-1))...
  92. doi IL-17A-producing gammadelta T and Th17 lymphocytes mediate lung inflammation but not fibrosis in experimental silicosis
    Sandra Lo Re
    Louvain Centre for Toxicology and applied Pharmacology, de Duve Institute, Universite Catholique de Louvain, Brussels, Belgium
    J Immunol 184:6367-77. 2010
    ..Although the acute alveolitis induced by silica is IL-17A dependent, this cytokine appears dispensable for the development of the late inflammatory and fibrotic lung responses to silica...
  93. ncbi Cytokine levels in bronchoalveolar lavage and serum in 3 patients with 2009 Influenza A(H1N1)v severe pneumonia
    Angel Estella
    Intensive Care Unit, Hospital de Jerez, Spain
    J Infect Dev Ctries 5:540-3. 2011
    Pandemic Influenza A (H1N1)v pneumonia has led to a notable increase of admissions to intensive care units. A cytokine-mediated inflammatory response has been well documented in pneumonia and acute respiratory distress syndrome...
  94. doi Prevalence and prognostic implications of dysphagia in elderly patients with pneumonia
    Mateu Cabre
    Department of Internal Medicine, Hospital de Mataro, Barcelona, Spain
    Age Ageing 39:39-45. 2010
    ..oropharyngeal dysphagia is a common condition among the elderly but not systematically explored...
  95. doi Predictors of death in under-five children with diarrhoea admitted to a critical care ward in an urban hospital in Bangladesh
    Mohammod J Chisti
    Clinical Sciences Division, International Centre for Diarrhoeal Disease Research ICDDR, B, Dhaka, Bangladesh
    Acta Paediatr 100:e275-9. 2011
    ..To evaluate the clinical and laboratory predictors of death in hospitalized under-five children with diarrhoea...
  96. pmc A preliminary study of pneumonia etiology among hospitalized children in Kenya
    Laura L Hammitt
    Department of International Health, International Vaccine Access Center, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21205, USA
    Clin Infect Dis 54:S190-9. 2012
    b>Pneumonia is the leading cause of childhood death in the developing world. Higher-quality etiological data are required to reduce this mortality burden.
  97. doi Cardiovascular and inflammatory biomarkers to predict short- and long-term survival in community-acquired pneumonia: Results from the German Competence Network, CAPNETZ
    Stefan Kruger
    Medical Clinic I, Rheinisch Westfälische Technische Hochschule University Aachen, Germany
    Am J Respir Crit Care Med 182:1426-34. 2010
    Several new biomarkers are related to mortality in community-acquired pneumonia (CAP).
  98. doi Amoebal pathogens as emerging causal agents of pneumonia
    Frederic Lamoth
    Infectious Diseases Service, University of Lausanne, Lausanne, Switzerland
    FEMS Microbiol Rev 34:260-80. 2010
    Despite using modern microbiological diagnostic approaches, the aetiological agents of pneumonia remain unidentified in about 50% of cases...
  99. pmc Cardiac complications in patients with community-acquired pneumonia: a systematic review and meta-analysis of observational studies
    Vicente F Corrales-Medina
    Department of Medicine, University of Ottawa, Ottawa, Ontario, Canada
    PLoS Med 8:e1001048. 2011
    Community-acquired pneumonia (CAP) is a leading cause of morbidity and mortality. CAP can trigger acute cardiac events...
  100. pmc Distinguishing malaria from severe pneumonia among hospitalized children who fulfilled integrated management of childhood illness criteria for both diseases: a hospital-based study in Mozambique
    Quique Bassat
    Barcelona Centre for International Health Research, Hospital Clinic, University of Barcelona, Spain
    Am J Trop Med Hyg 85:626-34. 2011
    Malaria and severe pneumonia in hospitalized young children may show striking clinical similarities, making differential diagnosis challenging...
  101. doi Predictors and outcomes of respiratory failure among hospitalized pneumonia patients with 2009 H1N1 influenza in Taiwan
    Yu San Chien
    Field Epidemiology Training Program, Centers for Disease Control, Taiwan, ROC
    J Infect 60:168-74. 2010
    ..We characterized the clinical features of the hospitalized pneumonia patients with 2009 H1N1 influenza in Taiwan and elucidated the risk of those patients for developing respiratory ..

Research Grants77

  1. Vaccine Development for Falciparum Malaria in Pregnant Women and Their Offspring
    Ian C Michelow; Fiscal Year: 2013
    ..in Pediatric Infectious Diseases and Tropical Medicine, his research on diagnostic tests for children with pneumonia or congenital syphilis, and his laboratory work on production of novel immunotherapeutics for glycosylated virus ..
  2. Prevention of Acute Lung Injury by IL-6 activated STAT3
    Ana Moran; Fiscal Year: 2010
    ..prevented T/HS-induced lung AEC apoptosis, decreased inflammation and edema as well as susceptibility to pneumonia, and decreased mortality 5-fold. Increased Stat3 activity was observed in the lungs of IL-6-treated vs...
  3. Inhibition of human neutrophil function by Francisella tularensis
    Lee Ann H Allen; Fiscal Year: 2012
    ..Project Narrative: Inhalation of the bacterium called Francisella tularensis causes severe, sometime fatal pneumonia and no vaccine is available...
  4. Effect of PPARy Ligands on Alcohol-Induced Alveolar Macrophage Oxidative Stress
    Samantha M Yeligar; Fiscal Year: 2013
    ..her repertoire of skills by receiving hands-on training in: a) techniques to perform and characterize Klebsiella pneumonia bacterial challenges in the airways of mouse models to assess alveolar macrophage phagocytosis in vivo, b) ..
  5. Global regulatory interactions in bacterial pathogenesis
    BRIAN AKERLEY; Fiscal Year: 2009
    ..disease including otitis media, exacerbations of chronic obstructive pulmonary disease, and community acquired pneumonia. In addition, some strains invade the bloodstream, causing bacteremia and meningitis. The mechanisms that H...
  6. Lactoferrin Enhances Growth and Reduces Nosocomial Infection in Preterm Infants
    Karel Petrak; Fiscal Year: 2009
    ..TLF to enhance post-natal growth and to attenuate the incidence of nosocomial infections (including bacteremia, pneumonia, urinary infection, necrotizing enterocolitis [NEC] plus "NEC scares", and meningitis)...
  7. Novel Bioconjugate Vaccines to Prevent Staphylococcus aureus Infection
    JEAN CLAIRE LEE; Fiscal Year: 2013
    ..of the multi-component bioconjugate vaccine in rodent models of staphylococcal infection, including bacteremia, pneumonia, wound infection, and endocarditis;(4) investigate the immune correlates of protection against S...
  8. The mechanisms by which alcohol and HIV render the lung susceptible to injury
    DAVID MARSHALL GUIDOT; Fiscal Year: 2013
    ..Notably, pneumonia and other pulmonary complications are the most common causes of death in HIV-1-infected individuals...
  9. New therapeutics for the treatment of Acinetobactor baumannii infections.
    ALLEN BERNARD REITZ; Fiscal Year: 2013
    ..They are responsible for clinically important infections that cause a wide variety of maladies including pneumonia, skin and wound infections, bacteremia and meningitis. In addition, A...
  10. Novel Means to Establish Free Radical Balance in the Neonatal Premature Lung
    Prakash Jagtap; Fiscal Year: 2011
    ..impairment with profound effects on quality of life and necessitating frequent and lifelong hospitalizations for pneumonia and bronchiolitis...
  11. Pilot Studies of the Effect of Aging on Mucociliary Clearance
    Lawrence E Ostrowski; Fiscal Year: 2013
    ..In this population, pneumonia is the leading cause of death due to infectious disease, and the incidence of community-acquired pneumonia ..
  12. Epidemiology and Etiology of Hospitalized Pneumonia in Children
    Krow Ampofo; Fiscal Year: 2010
    b>Pneumonia in children is a major cause of morbidity and mortality worldwide and the leading cause of death in children younger than 5 years of age worldwide...
  13. Lung VITamin D and OmegA-3 TriaL (Lung VITAL)
    Diane R Gold; Fiscal Year: 2013
    DESCRIPTION (provided by investigator): COPD and pneumonia are among the leading causes of morbidity and mortality in adults 60 years and older, and pneumonia rates are higher for those with COPD...
  14. SARS-CoV Pathogenic Mechanisms in Senescent Mice
    Ralph S Baric; Fiscal Year: 2012
    ..in civet cats and raccoon dogs and then transmitted to humans causing severe acute respiratory disease, pneumonia, and high mortality rates in the elderly...
  15. The Role of Alcohol in HIV Therapy Hepatotoxicity
    Craig J McClain; Fiscal Year: 2012
    ..be more likely to develop certain infectious diseases which can complicate HIV, examples being various types of pneumonia and tuberculosis...
  16. Modulation of host immune defense by Pneumocystis beta-glucans
    EVA MARIA CARMONA PORQUERA; Fiscal Year: 2013
    ..immune defense by Pneumocystis beta-glucans Pneumocystis are fungal organisms associated with the development of pneumonia in immunocompromised hosts...
  17. Optimization of Neoglycoside Antibiotics for Nosocomial Pathogens and Select Agen
    Arnold Louie; Fiscal Year: 2013
    ..These include a murine model of Gram-negative pneumonia and mouse thigh infection as a surrogate for skin/skin structure infection...
  18. Inhibitors of isoprenoid synthesis for antibacterial therapy
    Donald T Moir; Fiscal Year: 2013
    ..Burkholderia, Acinetobacter, and Stenotrophomonas, which are prevalent in severe nosocomial infections, such as pneumonia, bacteremia and urinary tract infections...
  19. Genetics of Cryptococcus sexual reproduction
    Joseph Heitman; Fiscal Year: 2013
    ..applicant): Cryptococcus neoformans and Cryptococcus gattii frequently infect humans to cause life-threatening pneumonia and meningitis resulting in considerable morbidity and mortality in both immunocompromised and immunocompetent ..
  20. Biofilm Infections in Postsurgical, Trauma, and Critically Ill Patients
    Carol L Wells; Fiscal Year: 2013
    ..These diseases include pneumonia in ventilated patients, endocarditis, burn wound infections, and infections of indwelling devices...
  21. Iowa Phase II Clinical Trials of Novel Therapies for Lung Diseases (U01
    Lakshmi Durairaj; Fiscal Year: 2012
    ..conditions in addition to CF, such as non-CF bronchiectasis, chronic bronchitis and ventilator associated pneumonia. RELEVANCE: Cystic fibrosis is the most common genetic lung disease in Caucasians...
  22. Analogs of GTP as novel inhibitors of bacterial c-di-GMP-synthesizing enzymes
    George E Wright; Fiscal Year: 2010
    ..that resist conventional antibiotics and are associated with numerous infectious diseases such as bacterial pneumonia, stent blockage, catheter colonization, etc...
  23. MIF AND THE HOST RESPONSE TO INFECTION
    RICHARD J BUCALA; Fiscal Year: 2013
    ..a significant association between functional alleles in the human MIF gene (MIF) and clinical outcome from pneumonia. We also cloned the MIF receptor and identified signaling to require a complex of two transmembrane proteins: ..
  24. Pulmonary Defenses Against Intracellular Infection
    Shawn J Skerrett; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Pneumonia is a leading cause of morbidity and mortality...
  25. Human cytomegalovirus entry into epithelial and endothelial cells
    David C Johnson; Fiscal Year: 2013
    ..However, infections in immunodeficient or immunosuppressed patients often cause severe disease including pneumonia, gastrointestinal syndromes, hepatitis, retinitis, and encephalitis...
  26. Molecular regulation of GM-CSF expression in alveolar epithelial cells
    Robert Paine; Fiscal Year: 2013
    ..AEC in the setting of lung injury leads to impaired AEC GM-CSF expression and increased susceptibility to lethal pneumonia. This process is reversed by treatment with GM-CSF...
  27. Mechanisms of adaptive immunity to P. aeruginosa in the lung
    Gregory P Priebe; Fiscal Year: 2013
    ..cause of serious infections in humans with a predilection for lung infections in the form of either acute pneumonia in hospitalized patients (usually associated with mechanical ventilation) or chronic pneumonia in people with ..
  28. Mechanisms of Haemophilus influenzae pathogenesis in the lung
    Hao Shen; Fiscal Year: 2013
    ..bacterium Haemophilus influenzae inhabits the human nasopharynx and conjunctiva, and can disseminate to cause pneumonia, otitis media, or meningitis...
  29. Cellular functions of the essential PcrA helicase in Staphylococcus aureus
    Saleem A Khan; Fiscal Year: 2013
    ..in Gram-positive bacteria, including important human pathogens such as Staphylococcus aureus, Streptococcus pneumonia, Clostridium perfringens, Listeria monocytogenes, Bacillus anthracis, etc. PcrA was discovered in S...
  30. High-throughput Screenings to Identify Host Receptors for Staphylococcal Adhesins
    Renata Pasqualini; Fiscal Year: 2012
    ..spectrum of infectious diseases spanning from rather minor skin infections to serious conditions such as sepsis, pneumonia and endocarditis...
  31. Research Career Development in Child Health
    Michael W Konstan; Fiscal Year: 2012
    ..of numerous childhood diseases, including lung disease associated with prematurity, cystic fibrosis, asthma, pneumonia, sepsis, cancer, coagulation disorders, bone marrow transplantation, diabetes, obesity and cardiovascular ..
  32. Cyclic AMP Signaling in Pseudomonas aeruginosa Virulence
    Matthew C Wolfgang; Fiscal Year: 2011
    ..culture infection and whether cAMP levels change with time and disease progression in a mouse model of acute pneumonia. The bacterium Pseudomonas aeruginosa is a major cause nosocomial infection and is the primary cause of ..
  33. Identification of new compounds against fungal microbes
    Maurizio Del Poeta; Fiscal Year: 2013
    ..The synthesis of GlcCer seems to be important also during Pneumocystis pneumonia (PCP) as glucosylceramide synthase transcripts have been found to be abundant at the time of isolation of the ..
  34. Mechanisms of Pleural Fibrosis in Empyema
    Kamal A Mohammed; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Abstract: Pneumonia is the most common cause of infection-related mortality. MRSA an emerging pathogen, now accounts for more than 55% of S. aureus -related infections1...
  35. Global Regulation of Gene expression in Streptococcus pneumoniae
    Bernard Weisblum; Fiscal Year: 2010
    ..As a pathogen, it spreads to the lungs (pneumonia), the central nervous system (meningitis), and the middle ear (otitis media). Mortality and morbidity due to S...
  36. CTRIP: Molecular phenotypes of rapidly progressive idiopathic pulmonary fibrosis
    Galen B Toews; Fiscal Year: 2010
    ..The most common idiopathic interstitial pneumonia (IIP) is IPF, whose histopathologic pattern is usual interstitial pneumonia...
  37. Haemophilus influenzae iron/heme regulon
    Terrence L Stull; Fiscal Year: 2012
    ..nontypable strains which remain a common cause of otitis media, the most common infection of childhood, and pneumonia. H. influenzae has an absolute growth requirement for heme and the human body is its sole niche...
  38. Nikkomycin Z treatment of early coccidioidal pneumonia: Phase II clinical trial
    DAVID LARWOOD; Fiscal Year: 2010
    ..We propose to develop the methods to make this drug at an affordable price and to study the newly made nikkomycin Z in humans to identify and select effective doses for future studies. ..
  39. Mechanisms to restrain social cheating from quorum sensing in Pseudomonas aerugin
    AJAI DANDEKAR; Fiscal Year: 2013
    ..It also causes difficult-to-treat burn and diabetic wound infections, keratitis, and ventilator-associated pneumonia. P...
  40. GENETICS AND VIRULENCE OF PNEUMOCOCCAL CAPSULAR TYPES
    JANET L YOTHER; Fiscal Year: 2012
    ..Serious infection and death result primarily from the ability of S. pneumoniae to cause pneumonia in the elderly, young children, and those with underlying conditions...
  41. Novel immunotherapeutics for the management of otitis media due to H. influenzae
    Steven D Goodman; Fiscal Year: 2013
    ..adenoiditis), the bronchus (chronic cough and bronchitis) and the lung (COPD, early stage CF, community acquired pneumonia)...
  42. Otitis media-associated pneumococcal genes
    Honggao Yan; Fiscal Year: 2013
    ..RELEVANCE: The bacterium Streptococcus pneumoniae is a major causative agent of middle ear infection, bacterial pneumonia, blood infection, and meningitis...
  43. Redox Regulation of Lung Mitochondrial Biogenesis in Sepsis/Pneumonia
    Claude A Piantadosi; Fiscal Year: 2013
    ..Using live S. aureus sepsi and pneumonia in mice and complementary lung cell studies, we will investigate how this integrated genetic network of ..
  44. Translational Approaches to Reducing Health Disparities in Lung Disease
    Joe G N Garcia; Fiscal Year: 2012
    ..that there are additional pressing areas in lung diseases, especially infectious diseases such as influenza, pneumonia and TB;however, we plan to address these topics in future conferences...
  45. Clinical Impact of Human Coronaviruses and Viral Diversity
    Geoffrey J Gorse; Fiscal Year: 2012
    ..more severe illnesses involving the respiratory tract may result, including those similar to influenza and even pneumonia. The impact of such infections on this population will be assessed in this four year study in terms of frequency ..
  46. Chicago Community-Acquired Pneumonia Consortium
    Richard G Wunderink; Fiscal Year: 2010
    Community-acquired pneumonia and influenza are the 8th most frequent primary and important secondary causes of death in the US...
  47. Planning a Multicenter Trial of PDE5A Inhibition for Duchenne Muscular Dystrophy
    Ronald G Victor; Fiscal Year: 2012
    ..Boys are diagnosed as toddlers, most are wheelchair bound by age 15, and death from pneumonia and heart failure often occurs by age 20...
  48. Regulation of NETosis in antibacterial lung defense
    EILEEN REMOLD-O'DONNELL; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Pneumonias resulting from failure to eradicate bacterial (Streptococcus pneumonia, Haemophilus influenza, Staphylococcus aureus, Pseudomonas aeruginosa) and viral (rhinovirus, influenza virus) ..
  49. The Roles of Conserved outer-membrane proteins in SFG rickettsia pathogenesis
    Juan J Martinez; Fiscal Year: 2013
    ..and brain can result in the most severe manifestations of disease including pulmonary edema and interstitial pneumonia. Although infections are controlled by broad-spectrum antibiotic therapies, untreated or misdiagnosed ..
  50. Polymicrobial interactions in the lung.
    JENNIFER MELINDA BOMBERGER; Fiscal Year: 2010
    ..and an important pathogen in patients with chronic obstructive pulmonary disorder (COPD), community acquired pneumonia (CAP), ventilator-associated pneumonia (VAP), non-CF bronchiectasis and cystic fibrosis (CF)...
  51. Single RNA sensitive probes for studying viral replication and budding
    Philip J Santangelo; Fiscal Year: 2013
    ..PUBLIC HEALTH RELEVANCE: Human respiratory syncytial virus (hRSV), an RNA virus, is the leading cause of viral pneumonia, bronchiolitis, respiratory failure, mechanical ventilation, and viral death in infants in the USA and worldwide,..
  52. Hospital and Household Studies of Respiratory Cryptosporidiosis and Transmission
    Jeffrey K Griffiths; Fiscal Year: 2013
    ..9-36 months who (Group A) have primary diarrhea and unexplained cough or tachypnea;or (Group B) primary clinical pneumonia with or without diarrhea...
  53. Peptide inhbitors of influenza entry-FAST TRACK
    Russell B Wilson; Fiscal Year: 2011
    ..one to two weeks, the very young, the elderly and persons with chronic medical conditions can develop post-flu pneumonia and other lethal complications...
  54. HLA class II transgenic mouse models for S. aureus infections and superantigens
    Govindarajan Rajagopalan; Fiscal Year: 2013
    ..a spectrum of diseases;from benign, localized skin infections to life-threatening, systemic illnesses including pneumonia, sepsis and menstrual or non-menstrual toxic shock syndromes (TSS). The virulence and pathogenicity of S...
  55. Biology of the HMW1 and HMW2 Adhesins of H. Influenzae
    JOSEPH W ST. GEME; Fiscal Year: 2013
    ..influenzae is a common cause of localized respiratory tract disease, especially otitis media, sinusitis, pneumonia, and exacerbations of chronic lung disease...
  56. Reducing Care-Resistant Behaviors During Oral Hygiene in Persons with Dementia
    Rita A Jablonski; Fiscal Year: 2013
    ..elders deteriorates in the absence of daily oral hygiene, predisposing them to harmful systemic problems such as pneumonia, hyperglycemia, cardiac disease, and cerebral vascular accidents...
  57. Role of Staphylococcus aureus alpha-hemolysin in disease
    Juliane Bubeck Wardenburg; Fiscal Year: 2013
    ..aureus strains. Hla is a potent epithelial toxin, contributing to the pathogenesis of pneumonia, skin and corneal infection, central nervous system infection, toxic shock syndrome and sepsis...
  58. Host defense against Staphylococcus aureus skin infections
    Lloyd S Miller; Fiscal Year: 2010
    ..and frequently life-threatening infections such as lymphangitis, septic arthritis, osteomyelitis, bacteremia, pneumonia, abscesses of various organs, meningitis, endocarditis, and sepsis...
  59. A Rapid Point-of-care Diagnostic for C. trachomatis STDs
    Richard F Selden; Fiscal Year: 2013
    ..pregnant woman is not treated, her baby has a 50% chance of developing conjunctivitis and a 20% chance of pneumonia in the first six months of life...
  60. Effects of Maternal Influenza Immunization: A Field Trial in Guatemala'
    Saad B Omer; Fiscal Year: 2010
    ..outcomes include clinical influenza-like illness, prematurity, birth weight, delivery complications, pneumonia and severe pneumonia (per WHO Integrated Management of Childhood Illness classification), hospitalizations due ..
  61. Immune response to Pneumocystis and bone marrow failure
    Nicole Meissner; Fiscal Year: 2013
    ..provided by applicant): In AIDS patients'susceptibility to opportunistic infections, such as Pneumocystis Pneumonia (PCP), occurs due to the loss of CD4 T cells and type I interferon (type-I-IFN) producing plasmacytoid dendritic ..
  62. Mechanisms of Haemophilus influenzae pathogenesis in the lung
    Hao Shen; Fiscal Year: 2011
    ..bacterium Haemophilus influenzae inhabits the human nasopharynx and conjunctiva, and can disseminate to cause pneumonia, otitis media, or meningitis...
  63. MULTICITY STUDY OF QUALITY OF CARE FOR HIV-RELATED TB
    Charles Bennett; Fiscal Year: 2000
    ..we will build on our ongoing projects that evaluate quality of care for HIV-related Pneumocystis carinii pneumonia (PCP) and community acquired pneumonia (CAP) in several cities...
  64. Synthetic saccharides to study immunological properties of Streptococcus pneumoni
    Alexei V Demchenko; Fiscal Year: 2010
    ..The bacteria Streptococcus pneumoniae (SPn) have become one of the most frequent causes of pneumonia, bacteremia, and meningitis in the elderly, immunocompromised, and especially in young children...
  65. Mulago Inpatient Noninvasive Diagnosis of Pneumocystis Pneumonia (MIND PCP) Study
    John Davis; Fiscal Year: 2007
    ..While tuberculosis (TB) and bacterial pneumonia are common, other processes may cause pneumonia in these patients, so bronchoscopy with bronchoalveolar lavage (..
  66. Susceptibility Testing, Treatment Choices, and Outcomes of MDR-GNB Infections
    Lisa Saiman; Fiscal Year: 2009
    ..Gram negative bacilli (GNB), such as Pseudomonas aeruginosa, Klebsiella pneumonia and Acinetobacter spp...
  67. Novel anti-bacterial therapy for gram negative pneumonia
    Kanneganti Murthy; Fiscal Year: 2001
    DESCRIPTION (provided by applicant):In spite of aggressive antibiotic therapy and supportive care, gram negative pneumonia remains a major cause of death and prolonged hospitalization...
  68. Aspiration Pneumonia in Children with Neurological Impairment
    Rajendu Srivastava; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Aspiration pneumonia (AP) is the most common cause of death in children with severe neurological impairment (Nl)...
  69. Impact of Fluoroquinolone resistance on Pseudomonas virulence and patient outcome
    Annie Wong Beringer; Fiscal Year: 2009
    ..Excess morbidity and mortality have been demonstrated for acute pneumonia caused by ExoU-secreting PA and FQ-resistant PA, raising the possibility that antibiotic resistance may be ..
  70. Etiology, Epidemiology, and Clinical Outcomes of Health Care Associated Pneumonia
    Karl Madaras Kelly; Fiscal Year: 2009
    ..Diseases Society of America (IDSA) have periodically published guidelines on the diagnosis and management of pneumonia. In 2005, the ATS/IDSA published guidelines which define a new subset of pneumonia entitled Health Care ..
  71. Can Chlamydial Infection Increase Host Mutation Frequency?
    ROBERT SCHOBORG; Fiscal Year: 2009
    ..C. pneumoniae is the most common cause of community-acquired pneumonia in the US;>90% of the US population has been infected with C. pneumoniae by age 40...
  72. Coaxial Everting Membrane Catheter Bronchoalveolar Lavag
    William Krause; Fiscal Year: 2006
    unreadable] DESCRIPTION (provided by applicant): Project Summary/Abstract: Ventilator-Associated Pneumonia (VAP) is pneumonia that develops in a mechanically ventilated patient later than 48 hours after intubation...
  73. Study of S pneumoniae Virulence Gene Regulation
    Andrew Camilli; Fiscal Year: 2002
    ..pneumoniae, the most common cause of bacteremia, bacterial meningitis, otitis media and community-acquired pneumonia in the U.S.A...
  74. Dose of Early Therapeutic Mobility: Does Type or Frequency of Activity Matter?
    Chris Winkelman; Fiscal Year: 2010
    ..Systemic markers of physical health (i.e., vital signs, delirium, muscle strength, ventilator associated pneumonia, and length of time mechanically ventilated) may also be positively influenced by ETM...
  75. IMMUNOLOGY OF BACTERIAL PNEUMONIA IN HTLV-II INFECTION
    GARY JARVIS; Fiscal Year: 2002
    ..the immunologic basis for the epidemiological outcome observation of an increased incidence of bacterial pneumonia in HTLV-II-infected blood donors...
  76. VARIABLE GENE DEFECTS AND PNEUMOCOCCAL SUSCEPTIBILITY
    Liise Anne Pirofski; Fiscal Year: 2010
    ..the proposal is on the relationship between the immune status of the host and Ab protection against pneumococcal pneumonia. Pneumococcal pneumonia is the leading cause of community acquired pneumonia in the U.S. and globally...
  77. How can caspases control intracellular pulmonary pathogens
    Amal O Amer; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Legionella pneumophila (Legionella) is the causative agent of a severe pneumonia called Legionnaires'disease...