pharyngitis

Summary

Summary: Inflammation of the throat.

Top Publications

  1. ncbi Pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections: clinical description of the first 50 cases
    S E Swedo
    Section on Behavioral Pediatrics, NIMH, Rockville Pike, Bethesda, MD 20892 1381, USA
    Am J Psychiatry 155:264-71. 1998
  2. ncbi The global burden of group A streptococcal diseases
    Jonathan R Carapetis
    Centre for International Child Health, University of Melbourne, Department of Paediatrics and Murdoch Childrens Research Institute, Royal Children s Hospital, Melbourne, Australia
    Lancet Infect Dis 5:685-94. 2005
  3. ncbi Practice guidelines for the diagnosis and management of group A streptococcal pharyngitis. Infectious Diseases Society of America
    Alan L Bisno
    Department of Medicine, University of Miami School of Medicine and Veterans Affairs Medical Center, Miami, FL 33125, USA
    Clin Infect Dis 35:113-25. 2002
  4. ncbi Correlations between controlled endotracheal tube cuff pressure and postprocedural complications: a multicenter study
    Jianhui Liu
    Department of Anesthesiology, Tongji Hospital, Tongji University School of Medicine, Shanghai, China
    Anesth Analg 111:1133-7. 2010
  5. ncbi Clinical practice guideline for the diagnosis and management of group A streptococcal pharyngitis: 2012 update by the Infectious Diseases Society of America
    Stanford T Shulman
    Department of Pediatrics, Division of Infectious Diseases, Ann and Robert H Lurie Children s Hospital, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    Clin Infect Dis 55:1279-82. 2012
  6. pmc Protective effect of antibiotics against serious complications of common respiratory tract infections: retrospective cohort study with the UK General Practice Research Database
    I Petersen
    UCL Centre for Infectious Disease Epidemiology, Department of Primary Care and Population Sciences, University College London, London NW3 2PQ
    BMJ 335:982. 2007
  7. pmc The validity of a sore throat score in family practice
    W J McIsaac
    Family Medicine Centre, Mount Sinai Hospital, Toronto, Ont
    CMAJ 163:811-5. 2000
  8. ncbi Accuracy of rapid strep testing in patients who have had recent streptococcal pharyngitis
    Robert D Sheeler
    Department of Family Medicine, Mayo Clinic, Rochester, MN 55905, USA
    J Am Board Fam Pract 15:261-5. 2002
  9. pmc Why do general practitioners prescribe antibiotics for sore throat? Grounded theory interview study
    Satinder Kumar
    Department of Primary Medical Care, University of Southampton, Southampton SO17 3RT
    BMJ 326:138. 2003
  10. pmc Group A Streptococcus emm gene types in pharyngeal isolates, Ontario, Canada, 2002-2010
    Patrick R Shea
    The Methodist Hospital Research Institute, Houston, Texas 77030, USA
    Emerg Infect Dis 17:2010-7. 2011

Detail Information

Publications309 found, 100 shown here

  1. ncbi Pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections: clinical description of the first 50 cases
    S E Swedo
    Section on Behavioral Pediatrics, NIMH, Rockville Pike, Bethesda, MD 20892 1381, USA
    Am J Psychiatry 155:264-71. 1998
    ....
  2. ncbi The global burden of group A streptococcal diseases
    Jonathan R Carapetis
    Centre for International Child Health, University of Melbourne, Department of Paediatrics and Murdoch Childrens Research Institute, Royal Children s Hospital, Melbourne, Australia
    Lancet Infect Dis 5:685-94. 2005
    ..are more than 111 million prevalent cases of GAS pyoderma, and over 616 million incident cases per year of GAS pharyngitis. Epidemiological data from developing countries for most diseases is poor...
  3. ncbi Practice guidelines for the diagnosis and management of group A streptococcal pharyngitis. Infectious Diseases Society of America
    Alan L Bisno
    Department of Medicine, University of Miami School of Medicine and Veterans Affairs Medical Center, Miami, FL 33125, USA
    Clin Infect Dis 35:113-25. 2002
  4. ncbi Correlations between controlled endotracheal tube cuff pressure and postprocedural complications: a multicenter study
    Jianhui Liu
    Department of Anesthesiology, Tongji Hospital, Tongji University School of Medicine, Shanghai, China
    Anesth Analg 111:1133-7. 2010
    ..In this study, we investigated the short-term (hours) impact of measuring and controlling endotracheal tube cuff (ETTc) pressure on postprocedural complications...
  5. ncbi Clinical practice guideline for the diagnosis and management of group A streptococcal pharyngitis: 2012 update by the Infectious Diseases Society of America
    Stanford T Shulman
    Department of Pediatrics, Division of Infectious Diseases, Ann and Robert H Lurie Children s Hospital, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    Clin Infect Dis 55:1279-82. 2012
    ..intended for use by healthcare providers who care for adult and pediatric patients with group A streptococcal pharyngitis. The guideline updates the 2002 Infectious Diseases Society of America guideline and discusses diagnosis and ..
  6. pmc Protective effect of antibiotics against serious complications of common respiratory tract infections: retrospective cohort study with the UK General Practice Research Database
    I Petersen
    UCL Centre for Infectious Disease Epidemiology, Department of Primary Care and Population Sciences, University College London, London NW3 2PQ
    BMJ 335:982. 2007
    ..To determine the extent to which antibiotics reduce the risk of serious complications after common respiratory tract infections...
  7. pmc The validity of a sore throat score in family practice
    W J McIsaac
    Family Medicine Centre, Mount Sinai Hospital, Toronto, Ont
    CMAJ 163:811-5. 2000
    ..The study also examined the potential impact of this clinical score on the prescribing of antibiotics in community-based family practice...
  8. ncbi Accuracy of rapid strep testing in patients who have had recent streptococcal pharyngitis
    Robert D Sheeler
    Department of Family Medicine, Mayo Clinic, Rochester, MN 55905, USA
    J Am Board Fam Pract 15:261-5. 2002
    Some clinicians have questioned the accuracy of rapid diagnosis of group A streptococcal pharyngitis by commercial immunochemical antigen test kits in the setting of recent streptococcal pharyngitis, believing that the false-positive ..
  9. pmc Why do general practitioners prescribe antibiotics for sore throat? Grounded theory interview study
    Satinder Kumar
    Department of Primary Medical Care, University of Southampton, Southampton SO17 3RT
    BMJ 326:138. 2003
    ..To understand why general practitioners prescribe antibiotics for some cases of sore throat and to explore the factors that influence their prescribing...
  10. pmc Group A Streptococcus emm gene types in pharyngeal isolates, Ontario, Canada, 2002-2010
    Patrick R Shea
    The Methodist Hospital Research Institute, Houston, Texas 77030, USA
    Emerg Infect Dis 17:2010-7. 2011
    Group A Streptococcus (GAS) is a human-adapted pathogen that causes a variety of diseases, including pharyngitis and invasive infections...
  11. pmc Large-scale validation of the Centor and McIsaac scores to predict group A streptococcal pharyngitis
    Andrew M Fine
    Department of Medicine, Division of Emergency Medicine, Children s Hospital Boston, Massachusetts, USA
    Arch Intern Med 172:847-52. 2012
    The Centor and McIsaac scores guide testing and treatment for group A streptococcal (GAS) pharyngitis in patients presenting with a sore throat, but they were derived on relatively small samples...
  12. pmc Update on the management of acute pharyngitis in children
    Marta Regoli
    Department of Sciences for Woman and Child s Health, University of Florence, Florence, Italy
    Ital J Pediatr 37:10. 2011
    Streptococcal pharyngitis is a very common pathology in paediatric age all over the world. Nevertheless there isn't a joint agreement on the management of this condition...
  13. ncbi Pharyngolaryngeal, neck, and jaw discomfort after anesthesia with the face mask and laryngeal mask airway at high and low cuff volumes in males and females
    J Brimacombe
    Department of Anaesthesia and Intensive Care Medicine, Cairns Base Hospital, Australia
    Anesthesiology 93:26-31. 2000
    ..In a randomized double-blind study, the authors compared laryngopharyngeal, neck, and jaw discomfort with the FM and LMA at high and low cuff volumes in males and females...
  14. ncbi Cold temperature and low humidity are associated with increased occurrence of respiratory tract infections
    Tiina M Mäkinen
    Institute of Health Sciences, University of Oulu, Finland
    Respir Med 103:456-62. 2009
    ..The association between cold exposure and acute respiratory tract infections (RTIs) has remained unclear. The study examined whether the development of RTIs is potentiated by cold exposure and lowered humidity in a northern population...
  15. pmc Cluster randomised controlled trial of tailored interventions to improve the management of urinary tract infections in women and sore throat
    Signe Flottorp
    Department of Health Services Research, Norwegian Directorate for Health and Social Welfare, PO Box 8054 Dep, N 0031 Oslo, Norway
    BMJ 325:367. 2002
    ..To assess the effectiveness of tailored interventions to implement guidelines for urinary tract infections in women and sore throat...
  16. ncbi Prevalence of streptococcal pharyngitis and streptococcal carriage in children: a meta-analysis
    Nader Shaikh
    Children s Hospital of Pittsburgh, General Academic Pediatrics, University of Pittsburgh School of Medicine, 3414 Fifth Ave, Pittsburgh, PA 15213 2583, USA
    Pediatrics 126:e557-64. 2010
    ..help clinicians make informed decisions regarding diagnostic testing of children who present with symptoms of pharyngitis. We conducted a meta-analysis to determine the (1) prevalence of streptococcal infection among children who ..
  17. ncbi Antibiotics for upper respiratory tract infections: an overview of Cochrane reviews
    B Arroll
    Department of General Practice and Primary Health Care, University of Auckland, Auckland New Zealand
    Respir Med 99:255-61. 2005
    ..The aim of this paper is to review the four Cochrane reviews of antibiotics for upper respiratory tract infections...
  18. ncbi Clinical signs and symptoms predicting influenza infection
    A S Monto
    University of Michigan, 3080 SPH 1, 109 Observatory St, Ann Arbor, MI 48109 2029, USA
    Arch Intern Med 160:3243-7. 2000
    ..In clinical practice, antiviral use has rarely been guided by antecedent laboratory diagnosis. Defined clinical predictors of an influenza infection can help guide timely therapy and avoid unnecessary antibiotic use...
  19. ncbi Spectrum bias of a rapid antigen detection test for group A beta-hemolytic streptococcal pharyngitis in a pediatric population
    Matthew C Hall
    Marshfield Clinic Research Foundation, Marshfield, Wisconsin 54449, USA
    Pediatrics 114:182-6. 2004
    ..detection testing (RADT) is often performed for diagnosis of group A beta-hemolytic streptococcal (GABHS) pharyngitis among children...
  20. pmc Periodic fever, aphthous stomatitis, pharyngitis, and adenitis (PFAPA) is a disorder of innate immunity and Th1 activation responsive to IL-1 blockade
    Silvia Stojanov
    National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 108:7148-53. 2011
    The syndrome of periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis (PFAPA) is the most common periodic fever disease in children. However, the pathogenesis is unknown...
  21. ncbi Utility and sensitivity of the sore throat pain model: results of a randomized controlled trial on the COX-2 selective inhibitor valdecoxib
    Bernard P Schachtel
    Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, CT, USA
    J Clin Pharmacol 47:860-70. 2007
    ..Changes were made to the study design by employing a different diagnostic index for tonsillo-pharyngitis, a different rating scale (derived from Lasagna's pain thermometer), and alternative analyses, individual ..
  22. ncbi The utility of rapid antigen detection testing for the diagnosis of streptococcal pharyngitis in low-resource settings
    Anne W Rimoin
    Department of Epidemiology, UCLA School of Public Health, 650 Charles E Young Drive S, CHS 41 275, Los Angeles, CA 90095, USA
    Int J Infect Dis 14:e1048-53. 2010
    To evaluate the utility of rapid antigen detection testing (RADT) for the diagnosis of group A streptococcal (GAS) pharyngitis in pediatric outpatient clinics in four countries with varied socio-economic and geographic profiles.
  23. ncbi Burden of acute sore throat and group A streptococcal pharyngitis in school-aged children and their families in Australia
    Margaret H Danchin
    Department of Paediatrics, University of Melbourne, Melbourne, Australia
    Pediatrics 120:950-7. 2007
    The objective of this study was to determine the incidence, transmission, carriage, and risk factors for group A streptococcal pharyngitis in school-aged children and their families.
  24. ncbi A smaller endotracheal tube combined with intravenous lidocaine decreases post-operative sore throat - a randomized controlled trial
    Y J Xu
    Department of Anesthesiology, Fudan University, Shanghai Cancer Center, Shanghai, China
    Acta Anaesthesiol Scand 56:1314-20. 2012
    ..We conducted a trial to evaluate the effect of non-pharmacological [smaller-sized endotracheal tube (ETT)] combined with pharmacological intervention [lidocaine intravenous (i.v.)] on POST in women undergoing thyroid surgery...
  25. ncbi Gender differences in risk factors for airway symptoms following tracheal intubation
    M Jaensson
    Department of Anesthesiology and Intensive Care, Orebro University Hospital, Orebro, Sweden
    Acta Anaesthesiol Scand 56:1306-13. 2012
    ..The aim of this study was to describe gender differences and independent risk factors in the development of post-operative sore throat and hoarseness after endotracheal intubation in adults...
  26. pmc Resistance to erythromycin and telithromycin in Streptococcus pyogenes isolates obtained between 1999 and 2002 from Greek children with tonsillopharyngitis: phenotypic and genotypic analysis
    Ioanna N Grivea
    University of Patras, School of Medicine, Greece
    Antimicrob Agents Chemother 50:256-61. 2006
    ..High incidence of macrolide resistance and clonal spread of telithromycin resistance were the characteristics of the Greek S. pyogenes isolates obtained from 1999 to 2002...
  27. ncbi Endotracheal tube size and sore throat following surgery: a randomized-controlled study
    M Jaensson
    Department of Anaesthesiology and Intensive Care, Orebro University Hospital, Orebro, Sweden
    Acta Anaesthesiol Scand 54:147-53. 2010
    ..This study was carried out with the primary aim of assessing whether the size of the endotracheal tube (ETT) affects the risk of sore throat in women following anaesthesia...
  28. pmc Clinical score and rapid antigen detection test to guide antibiotic use for sore throats: randomised controlled trial of PRISM (primary care streptococcal management)
    Paul Little
    University of Southampton Medical School, Aldermoore Health Centre, Southampton SO16 5ST, UK
    BMJ 347:f5806. 2013
    ..To determine the effect of clinical scores that predict streptococcal infection or rapid streptococcal antigen detection tests compared with delayed antibiotic prescribing...
  29. ncbi Detection of invasive protein profile of Streptococcus pyogenes M1 isolates from pharyngitis patients
    Tadao Hasegawa
    Department of Bacteriology, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Nagoya, Japan
    APMIS 118:167-78. 2010
    ..Markedly different profiles among isolates after 1990 from STSS and pharyngitis patients were detected...
  30. ncbi Risk factors associated with postoperative sore throat after tracheal intubation: an evaluation in the postanesthetic recovery room
    Kuan Ting Chen
    Department of Anesthesiology, Chi Mei Medical Center, Tainan, Taiwan, R O C
    Acta Anaesthesiol Taiwan 42:3-8. 2004
    ..The aim of the study was to carry out a large-scale search for the risk factors of postoperative sore throat in patients undergoing endotracheal general anesthesia...
  31. pmc Use of antibiotics for sore throat and incidence of quinsy
    Nick Dunn
    University of Southampton, Biomedical Sciences Building, Southampton, SO16 7PX
    Br J Gen Pract 57:45-9. 2007
    ..Quinsy is the most common major suppurative complication of sore throat. Evidence on the effectiveness of antibiotics in preventing quinsy is sparse...
  32. pmc Penicillin for acute sore throat: randomised double blind trial of seven days versus three days treatment or placebo in adults
    S Zwart
    Julius Center for General Practice and Patient Oriented Research, University Medical Center Utrecht, 3584 CG Utrecht, Netherlands
    BMJ 320:150-4. 2000
    ..To assess whether treatment with penicillin for three days and the traditional treatment for seven days were equally as effective at accelerating resolution of symptoms in patients with sore throat compared with placebo...
  33. ncbi Effects of decreasing endotracheal tube cuff pressures during neck retraction for anterior cervical spine surgery
    Jebadurai Ratnaraj
    Department of Anesthesiology, Washington University School of Medicine, Saint Louis, Missouri, USA
    J Neurosurg 97:176-9. 2002
    ....
  34. ncbi Quality improvement in anesthetic practice--incidence of sore throat after using small tracheal tube
    Ali S Al-Qahtani
    Armed Forces Hospital, P O Box 228, Wadi Al Dawasir 11991, Saudi Arabia
    Middle East J Anaesthesiol 18:179-83. 2005
    ..A prospective study was conducted to demonstrate the incidence of hoarseness and sore throat following the use of small tracheal tubes...
  35. pmc Impact on antibiotic prescription of rapid antigen detection testing in acute pharyngitis in adults: a randomised clinical trial
    Carl Llor
    Primary Healthcare Centre Jaume I, Tarragona, University Rovira i Virgili, Spain
    Br J Gen Pract 61:e244-51. 2011
    Acute pharyngitis is one of the most frequent reasons for a GP consultation, and in most cases an antibiotic is prescribed.
  36. pmc Spectrum and inoculum size effect of a rapid antigen detection test for group A streptococcus in children with pharyngitis
    Jérémie F Cohen
    Unité de Recherche Epidémiologique en Santé Périnatale et Santé des Femmes et des Enfants U953, INSERM, Paris, France
    PLoS ONE 7:e39085. 2012
    ..We aimed to assess whether the performance of a rapid antigen detection test (RADT) for group A streptococcus (GAS) is affected by the clinical spectrum and/or bacterial inoculum size...
  37. ncbi Effect of clinical spectrum, inoculum size and physician characteristics on sensitivity of a rapid antigen detection test for group A streptococcal pharyngitis
    J F Cohen
    INSERM, UMR S953, Epidemiological Research Unit on Perinatal Health and Women s and Children s Health, Maternité de Port Royal, 6e étage, 53 avenue de l Observatoire, 75014, Paris, France
    Eur J Clin Microbiol Infect Dis 32:787-93. 2013
    ..Double throat swabs were collected from 1,482 children with pharyngitis and 294 asymptomatic children in a French prospective, office-based, multicenter (n = 17) study, from October ..
  38. ncbi Diagnosis and treatment of streptococcal pharyngitis
    Beth A Choby
    Department of Family Medicine, University of Tennessee College of Medicine Chattanooga, UT Family Practice Center, 37403, USA
    Am Fam Physician 79:383-90. 2009
    Common signs and symptoms of streptococcal pharyngitis include sore throat, temperature greater than 100.4 degrees F (38 degrees C), tonsillar exudates, and cervical adenopathy...
  39. ncbi Impact of laryngeal mask airway cuff pressures on the incidence of sore throat in children
    Justin Gin Leong Wong
    Department of Anaesthesia, Princess Margaret Hospital for Children, Subiaco, WA 6008, Australia
    Paediatr Anaesth 19:464-9. 2009
    ..In a prospective audit, we assessed the incidence of sore throat following day-case-surgery in relation to the intracuff pressure within the laryngeal mask airway...
  40. ncbi Local oropharyngeal side effects of inhaled corticosteroids in patients with asthma
    R Buhl
    Mainz University Hospital, Mainz, Germany
    Allergy 61:518-26. 2006
    ..These local side effects--including oropharyngeal candidiasis, dysphonia, pharyngitis, and cough--are generally viewed as minor complications of therapy...
  41. ncbi Expand the pharyngitis paradigm for adolescents and young adults
    Robert M Centor
    Huntsville Regional Medical Campus, University of Alabama at Birmingham, 301 Governors Drive, Huntsville, AL 35801, USA
    Ann Intern Med 151:812-5. 2009
    ..should consider group A beta-hemolytic streptococcus in the diagnosis and management of patients with acute pharyngitis. Recent data suggest that in adolescents and young adults (persons aged 15 to 24 years), Fusobacterium ..
  42. pmc Symptoms of cough and shortness of breath among occasional young adult smokers
    Lawrence C An
    Department of General Medicine, University of Minnesota Medical School, University of Minnesota, 420 Delaware Street SE, Minneapolis, MN 55455, USA
    Nicotine Tob Res 11:126-33. 2009
    ..The perception of negative health consequences is a common motive for quitting smoking, but specific information on the immediate health effects of occasional smoking among young adults is limited...
  43. ncbi Performance of a rapid antigen-detection test and throat culture in community pediatric offices: implications for management of pharyngitis
    Robert R Tanz
    Department of Pediatrics, Children s Memorial Hospital and Northwestern University Feinberg School of Medicine, Chicago, IL 60614, USA
    Pediatrics 123:437-44. 2009
    ..antigen-detection test and blood agar plate culture performed and interpreted in community pediatric offices and to assess the effect of the pretest likelihood of group A streptococcus pharyngitis on test performance (spectrum bias).
  44. ncbi Diagnosis and treatment of pharyngitis in children
    Michael A Gerber
    Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA
    Pediatr Clin North Am 52:729-47, vi. 2005
    Acute pharyngitis is one of the most common illnesses for which children visit primary care physicians. Most cases of acute pharyngitis in children are caused by viruses and are benign and self-limited...
  45. pmc Protein array profiling of tic patient sera reveals a broad range and enhanced immune response against Group A Streptococcus antigens
    Mauro Bombaci
    Novartis Vaccines and Diagnostics, Siena, Italy
    PLoS ONE 4:e6332. 2009
    ..pathogen Group A Streptococcus (Streptococcus pyogenes, GAS) is widely recognized as a major cause of common pharyngitis as well as of severe invasive diseases and non-suppurative sequelae associated with the existence of GAS ..
  46. pmc Predicting streptococcal pharyngitis in adults in primary care: a systematic review of the diagnostic accuracy of symptoms and signs and validation of the Centor score
    Jolien Aalbers
    HRB Centre for Primary Care Research, Department of General Practice, RCSI Medical School, Dublin, Republic of Ireland
    BMC Med 9:67. 2011
    ..accuracy of signs and symptoms and validate a clinical prediction rule (CPR), the Centor score, for predicting group A β-haemolytic streptococcal (GABHS) pharyngitis in adults (> 14 years of age) presenting with sore throat symptoms.
  47. ncbi Experimental investigation of the immunoregulatory and anti-inflammatory effects of the traditional Chinese medicine "Li-Yan Zhi-Ke Granule" for relieving chronic pharyngitis in rats
    Yiyi Sun
    Chengdu Medical College, and West China Hospital, Chengdu, 610083, Sichuan Province, China
    Mol Biol Rep 38:199-203. 2011
    Chronic pharyngitis, a chronic inflammation of the pharyngeal mucous membrane and submucous lymphoid tissues, is often caused by unsatisfactory treatment of acute pharyngitis or repeated occurrences of upper respiratory tract infection ..
  48. pmc Bacitracin-resistant clone of Streptococcus pyogenes isolated from pharyngitis patients in Belgium
    Surbhi Malhotra-Kumar
    Department of Microbiology, University of Antwerp UIA, Antwerp, Belgium
    J Clin Microbiol 41:5282-4. 2003
    We report 16 bacitracin-resistant Streptococcus pyogenes isolates recovered from pharyngitis patients in Belgium, 14 of which belonged to a particular emm type (emm28)...
  49. ncbi Distribution of streptococcal inhibitor of complement variants in pharyngitis and invasive isolates in an epidemic of serotype M1 group A Streptococcus infection
    N P Hoe
    Laboratory of Human Bacterial Pathogenesis, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 903 S. 4th St, Hamilton, Montana 59840, USA
    J Infect Dis 183:633-9. 2001
    ..To gain further understanding of the molecular basis of M1 epidemics, the sic gene was sequenced from 471 pharyngitis and 127 pyogenic and blood isolates recovered from 598 patients living in metropolitan Helsinki, Finland, ..
  50. ncbi [Rapid antigen detection tests for diagnosis of group A streptococcal pharyngitis: comparative evaluation of sensitivity and practicability of 16 in vitro diagnostics medical devices performed in July 2002 by the French health products safety agency (Afss
    N Charlier-Bret
    Agence française de sécurité sanitaire des produits de santé Afssaps DEDIM UECM DIV Unité évaluation et contrôle du marché Diagnostic in vitro, 93000 Saint Denis, France
    Pathol Biol (Paris) 52:438-43. 2004
    ..Regarding practicability, the results suggest that, the immunochromatographic strip methods have the best score in a view with the use by a non medical laboratory...
  51. ncbi Case-control study of clinical features of influenza in hospitalized patients
    Hilary M Babcock
    Washington University School of Medicine, Infectious Diseases Division, St Louis, Missouri 63110, USA
    Infect Control Hosp Epidemiol 29:921-6. 2008
    ..Few data exist on the clinical presentation of influenza in hospitalized patients, which may be distinct from the clinical presentation of influenza in ambulatory patients because of underlying medical conditions and medications...
  52. ncbi Biofilm formation or internalization into epithelial cells enable Streptococcus pyogenes to evade antibiotic eradication in patients with pharyngitis
    Taiji Ogawa
    Department of Oral and Molecular Microbiology, Osaka University Graduate School of Dentistry, 1 8 Yamadaoka, Suita, Osaka 565 0871, Japan
    Microb Pathog 51:58-68. 2011
    Streptococcus pyogenes is the bacterium most frequently isolated from patients with pharyngitis. Although various antibiotics including penicillin are effective, antibiotic treatment failure in cases of streptococcal pharyngitis have ..
  53. ncbi Seroprevalence of Helicobacter pylori infection in patients with chronic nonspecific pharyngitis: preliminary study
    I Aladag
    Department of ORL, Faculty of Medicine, Gaziosmanpasa University, Tokat, Turkey
    J Laryngol Otol 122:61-4. 2008
    Chronic nonspecific pharyngitis is a chronic inflammation of the pharynx. It is found worldwide, and treatment is difficult. The underlying aetiopathogenesis is still controversial...
  54. ncbi Guidelines for sore throat management in New Zealand
    Melissa Kerdemelidis
    Community Paediatrics, School of Population Health, The University of Auckland, Auckland, New Zealand
    N Z Med J 122:10-8. 2009
    ..An algorithm and guideline for appropriate screening and management of sore throats in the New Zealand setting was crafted to guide appropriate treatment in high risk rheumatic fever areas and reduce antibiotic use in low risk areas...
  55. ncbi Pharyngitis clinical prediction rules: effect of interobserver agreement: a MetroNet study
    Kendra Schwartz
    Division of Practice Based Research, Department of Family Medicine, Wayne State University, 101 East Alexandrine, Detroit, MI 48201, USA
    J Clin Epidemiol 57:142-6. 2004
    b>Pharyngitis clinical prediction rules improve Group A beta-hemolytic streptococcus (GABHS) diagnosis and decrease unnecessary antibiotic use, yet few studies have addressed clinician variability in assessment of sore throat signs and ..
  56. ncbi Empirical validation of guidelines for the management of pharyngitis in children and adults
    Warren J McIsaac
    Ray D Wolfe Department of Family Medicine, Mount Sinai Hospital, Toronto, Ontario, Canada
    JAMA 291:1587-95. 2004
    Recent guidelines for management of pharyngitis vary in their recommendations concerning empirical antibiotic treatment and the need for laboratory confirmation of group A streptococcus (GAS).
  57. ncbi Analysis of different recommendations from international guidelines for the management of acute pharyngitis in adults and children
    Elena Chiappini
    Department of Sciences for Woman and Child s Health, University of Florence, Florence, Italy
    Clin Ther 33:48-58. 2011
    Streptococcal pharyngitis is a frequently observed condition, but its optimal management continues to be debated.
  58. pmc Antibiotics for the primary prevention of acute rheumatic fever: a meta-analysis
    Katharine A Robertson
    Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa
    BMC Cardiovasc Disord 5:11. 2005
    ....
  59. ncbi Predicting influenza infections during epidemics with use of a clinical case definition
    G Boivin
    Research Center in Infectious Diseases and Centre Hospitalier Universitaire de Québec, Quebec City, Quebec, Canada
    Clin Infect Dis 31:1166-9. 2000
    ..8%, 39.3%, 77.6%, and 55.0%, respectively...
  60. ncbi Management of Group A beta-hemolytic streptococcal pharyngitis
    C S Hayes
    Department of Family and Community Medicine, University of Missouri Columbia School of Medicine, USA
    Am Fam Physician 63:1557-64. 2001
    Bacteria are responsible for approximately 5 to 10 percent of pharyngitis cases, with group A beta-hemolytic streptococci being the most common bacterial etiology...
  61. pmc Illustration of a common framework for relating multiple typing methods by application to macrolide-resistant Streptococcus pyogenes
    J A Carriço
    Grupo de Biomatemática, Istituto de Tecnologia Química e Biológica, Universidade Nova de Lisboa, Rua da Quinta Grande 6 2780 156 Oeiras, Portugal
    J Clin Microbiol 44:2524-32. 2006
    ..A collection of 325 macrolide-resistant Streptococcus pyogenes isolates associated with pharyngitis cases in Portugal was used to benchmark the proposed measures...
  62. ncbi Burden and economic cost of group A streptococcal pharyngitis
    Elizabeth Pfoh
    Department of Ambulatory Care and Prevention, Harvard Medical School and Harvard Pilgrim Health Care, 133 Brookline Ave, Boston, MA 02215, USA
    Pediatrics 121:229-34. 2008
    Our aim was to describe the morbidity, medical costs, and nonmedical costs associated with group A streptococcal pharyngitis in school-aged children.
  63. pmc A clinical score to reduce unnecessary antibiotic use in patients with sore throat
    W J McIsaac
    Mount Sinai Family Medical Centre, Department of Family and Community Medicine, University of Toronto, Ont
    CMAJ 158:75-83. 1998
    ..To validate a score based on clinical symptoms and signs for the identification of group A Streptococcus (GAS) infection in general practice patients with score throat...
  64. ncbi HLA-C and guttate psoriasis
    E Mallon
    Tissue Typing Laboratory, Churchill Hospital, Oxford, U K
    Br J Dermatol 143:1177-82. 2000
    ..Guttate psoriasis is a specific clinical manifestation of psoriasis frequently associated with group A beta-haemolytic streptococcal throat infection...
  65. ncbi Effectiveness of clinical guidelines for the presumptive treatment of streptococcal pharyngitis in Egyptian children
    M C Steinhoff
    Department of International Health, School of Hygiene and Public Health, Baltimore MD, USA
    Lancet 350:918-21. 1997
    Primary prevention of acute rheumatic fever requires antibiotic treatment of acute streptococcal pharyngitis. In developing countries, clinicians must rely on clinical guidelines for presumptive treatment of streptococcal pharyngitis ..
  66. ncbi Complaints of sore throat after tracheal intubation: a prospective evaluation
    P Biro
    University Hospital Zurich, Institute of Anaesthesiology, Zurich, Switzerland
    Eur J Anaesthesiol 22:307-11. 2005
    ..Our intention was to determine the incidence of postoperative sore throat from a large sample of patients and thus to identify the most important associated factors...
  67. ncbi Impact of rapid streptococcal test on antibiotic use in a pediatric emergency department
    Steve Ayanruoh
    Department of Emergency Medicine, Lincoln Medical and Mental Health Center, 234 E 149th St, Bronx, NY 10451, USA
    Pediatr Emerg Care 25:748-50. 2009
    Acute pharyngitis is commonly seen in children...
  68. ncbi Risk factors and natural history of habitual snoring
    Michael S Urschitz
    Department of Neonatology, University Hospital of Tuebingen, Calwerstr 7, 72076 Tuebingen, Germany
    Chest 126:790-800. 2004
    ..It has been suggested that habitual snoring (HS) has adverse health outcomes in children. We aimed to identify risk factors for HS and determine its natural history in primary school children...
  69. ncbi Inhaled fluticasone propionate reduces postoperative sore throat, cough, and hoarseness
    Nasrin Faridi Tazeh-Kand
    Roointan Arash Hospital, Tehranpars, Tehran, Iran
    Anesth Analg 111:895-8. 2010
    ..Postoperative cough and hoarseness can also be distressing to patients. We sought to determine the effect of an inhaler steroid on sore throat, cough, and hoarseness during the first 24 hours of the postoperative period...
  70. ncbi Tonsillectomy and adenotonsillectomy for recurrent throat infection in moderately affected children
    Jack L Paradise
    Department of Pediatrics, Children s Hospital of Pittsburgh, Pittsburgh, Pennsylvania 15213 2583, USA
    Pediatrics 110:7-15. 2002
    ....
  71. ncbi The rational clinical examination. Does this patient have strep throat?
    M H Ebell
    Department of Family Practice, Michigan State University, East Lansing 48824 1315, USA
    JAMA 284:2912-8. 2000
    Sore throat is a common complaint, and identifying patients with group A beta-hemolytic streptococcal pharyngitis (strep throat) is an important task for clinicians...
  72. ncbi Efficacy and tolerability of a spray with Salvia officinalis in the treatment of acute pharyngitis - a randomised, double-blind, placebo-controlled study with adaptive design and interim analysis
    Michael Hubbert
    Sidroga GmbH, D 79704 Bad Säckingen, Germany
    Eur J Med Res 11:20-6. 2006
    ..II/III study with adaptive two-stage design and interim analysis compared the efficacy and tolerability of spray (containing a Salvia officinalis fluid extract) against placebo in the treatment of patients with acute viral pharyngitis. -
  73. pmc M proteins of group C streptococci isolated from patients with acute pharyngitis
    A L Bisno
    Medical Service, Miami Veterans Affairs Medical Center, Florida 33125, USA
    J Clin Microbiol 34:2511-5. 1996
    ..equisimilis) [corrected] isolated from the throats of college students with acute pharyngitis and 5 strains isolated from patients with noninfectious problems...
  74. ncbi Oral dexamethasone for the treatment of pain in children with acute pharyngitis: a randomized, double-blind, placebo-controlled trial
    Blake Bulloch
    Department of Pediatrics, Children s Hospital, University of Manitoba, Winnipeg, Canada
    Ann Emerg Med 41:601-8. 2003
    We compare oral dexamethasone with placebo for the relief of pain in children with acute pharyngitis.
  75. pmc Environmental and non-infectious factors in the aetiology of pharyngitis (sore throat)
    Bertold Renner
    Department of Experimental and Clinical Pharmacology, University of Erlangen Nuremberg, Krankenhausstr 9, 91054 Erlangen, Germany
    Inflamm Res 61:1041-52. 2012
    The aim of this review is to examine the causes, pathophysiology and experimental models of non-infectious pharyngitis (sore throat).
  76. ncbi In vitro evaluation of five rapid antigen detection tests for group A beta-haemolytic streptococcal sore throat infections
    Gemma M Lasseter
    Health Protection Agency, Primary Care Unit, Microbiology, Gloucester Royal Hospital, Gloucester GL1 3NN, UK
    Fam Pract 26:437-44. 2009
    ..Yet in the UK, the Clinical Knowledge Summaries, that provide the main online guidance for GPs, discourage RADTs use, citing their poor sensitivity and inability to impact on prescribing decisions in acute sore throat infections...
  77. ncbi Dexamethasone reduces the severity of postoperative sore throat
    Siji Thomas
    Department of Anesthesiology, Amala Institute of Medical Sciences, Thrissur, Kerala, India
    Can J Anaesth 54:897-901. 2007
    ....
  78. pmc Group A Streptococcus gene expression in humans and cynomolgus macaques with acute pharyngitis
    Kimmo Virtaneva
    Laboratory of Human Bacterial Pathogenesis, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases National Institutes of Health, 903 South 4th Street, Hamilton, MT 59840, USA
    Infect Immun 71:2199-207. 2003
    ..molecular mechanisms used by group A Streptococcus (GAS) to survive on the host mucosal surface and cause acute pharyngitis are poorly understood...
  79. pmc Emergence of macrolide-resistant Streptococcus pyogenes strains in French children
    Edouard Bingen
    Universite Denis Diderot Paris 7, Service de Microbiologie, Hopital Robert Debre, 48 Bd Serurier, 75019 Paris, France
    Antimicrob Agents Chemother 48:3559-62. 2004
    ..A total of 22.4% were erythromycin resistant, and 69.4, 4.2, and 26.4% of these isolates harbored ermB, ermA, and mefA, respectively. Increasing resistance in France is mainly associated with a few emm type 28 clones...
  80. ncbi A non-human primate model of acute group a Streptococcus pharyngitis
    Paul Sumby
    Center for Molecular and Translational Hman Infectious Diseases Research, The Methodist Hospital Research Institute, Houston, TX, USA
    Methods Mol Biol 431:255-67. 2008
    This chapter describes methods for using non-human primates as a model of group A streptococcal (GAS) pharyngitis. This model has been used successfully to study host-pathogen interactions occurring during pharyngeal GAS infections...
  81. ncbi A meta-analysis of interventions to increase adherence to medication regimens for pediatric otitis media and streptococcal pharyngitis
    Yelena P Wu
    Clinical Child Psychology Program, 2011 Dole Human Development Center, University of Kansas, 1000 Sunnyside Avenue, Lawrence, KS 66045 7555, USA
    J Pediatr Psychol 33:789-96. 2008
    ....
  82. ncbi Community-based surveillance in the united states of macrolide-resistant pediatric pharyngeal group A streptococci during 3 respiratory disease seasons
    Robert R Tanz
    Division of General Academic Pediatrics, Children s Memorial Hospital, Chicago, IL 60614, USA
    Clin Infect Dis 39:1794-801. 2004
    ..In 2001, a total of 48% of pharyngeal group A streptococci (GAS) from Pittsburgh children were macrolide resistant. We assessed macrolide resistance, resistance genes, and emm types among GAS in the United States...
  83. ncbi Clinical practice guideline for the diagnosis and management of group A streptococcal pharyngitis: 2012 update by the Infectious Diseases Society of America
    Stanford T Shulman
    Department of Pediatrics, Division of Infectious Diseases, Ann and Robert H Lurie Children s Hospital, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    Clin Infect Dis 55:e86-102. 2012
    ..intended for use by healthcare providers who care for adult and pediatric patients with group A streptococcal pharyngitis. The guideline updates the 2002 Infectious Diseases Society of America guideline and discusses diagnosis and ..
  84. ncbi [Streptococcal pharyngitis in the pediatric emergency department: value and impact of rapid antigen detection test]
    N Buchbinder
    Service des urgences pédiatriques, hôpital Flaubert, Groupe Hospitalier, 55 bis, rue Gustave Flaubert, 76600 Le Havre, France
    Arch Pediatr 14:1057-61. 2007
    ..The French Health Agency (Afssaps) recommands the resort to the streptocoque rapid test strip for a better targetting of antibiotics prescription...
  85. ncbi Sensitivity and specificity of rapid antigen detection testing for diagnosing pharyngitis in the emergency department
    Sezgin Sarikaya
    Emergency Department, Yeditepe University Hospital, Devlet Yolu Ankara Cad 102 104, Istanbul, Turkey 34778
    Ear Nose Throat J 89:180-2. 2010
    Acute pharyngitis in adults is primarily a viral infection; only about 10% of cases are of bacterial etiology. Most cases of bacterial pharyngitis are caused by group A beta-hemolytic streptococci (GABHS)...
  86. pmc Penicillin for acute sore throat in children: randomised, double blind trial
    Sjoerd Zwart
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Stratenum 6 131, PO Box 85060, 3508 AB Utrecht, Netherlands
    BMJ 327:1324. 2003
    ..To assess the effectiveness of penicillin for three days and treatment for seven days compared with placebo in resolving symptoms in children with sore throat...
  87. ncbi Acute rheumatic fever: a chink in the chain that links the heart to the throat?
    Malcolm McDonald
    Infectious Diseases and International Health Unit, Menzies School of Health Research and Charles Darwin University, Darwin, New Territories, Australia
    Lancet Infect Dis 4:240-5. 2004
    ..It has long been thought that group A streptococcal (GAS) pharyngitis alone was responsible for acute rheumatic fever; this belief has been supported by laboratory and ..
  88. ncbi Burden of disease and barriers to the diagnosis and treatment of group a beta-hemolytic streptococcal pharyngitis for the prevention of rheumatic heart disease in Dar Es Salaam, Tanzania
    Regan Bergmark
    Harvard Medical School, Cannon Society, Boston, MA 02115, USA
    Pediatr Infect Dis J 29:1135-7. 2010
    To understand patient and clinician attitudes toward Streptococcus pharyngitis and rheumatic heart disease prevention in Tanzania, data from 3 sources were obtained: a survey of 119 clinicians, outpatient rapid test screening, and ..
  89. ncbi Dexpanthenol pastille and benzydamine hydrochloride spray for the prevention of post-operative sore throat
    N Gulhas
    Departments of Anaesthesiology, Inonu University School of Medicine, Malatya, Turkey
    Acta Anaesthesiol Scand 51:239-43. 2007
    ..In this study, we aimed to compare the effectiveness of dexpanthenol pastille and benzydamine hydrochloride spray on the prevention of a sore throat...
  90. ncbi Colchicine prophylaxis for frequent periodic fever, aphthous stomatitis, pharyngitis and adenitis episodes
    Diana Tasher
    The Pediatric Infectious and Immunology Unit, E Wolfson Medical Center, Holon, and the Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
    Acta Paediatr 97:1090-2. 2008
    To review our experience with colchicine for the prophylaxis of PFAPA (periodic fever, aphthous stomatitis, pharyngitis, adenitis).
  91. ncbi Genetic susceptibility to rheumatic heart disease and streptococcal pharyngitis: association with HLA-DR alleles
    F E Haydardedeoglu
    Department of Internal Medicine, Ankara University School of Medicine, Ankara, Turkey
    Tissue Antigens 68:293-6. 2006
    ..as a consequence of an exaggerated immune response to group A beta-haemolytic streptococci, which causes pharyngitis. Major manifestations of ARF include carditis, arthritis and chorea...
  92. ncbi Decline in erythromycin resistance in group A Streptococci from acute pharyngitis due to changes in the emm Genotypes rather than restriction of antibiotic use
    Eunha Koh
    Department of Laboratory Medicine, Gyeongsang National University School of Medicine, Gyeongsang Institute of Health Sciences, Jinju, Korea
    Korean J Lab Med 30:485-90. 2010
    Group A streptococcus (GAS) is the most common cause of bacterial pharyngitis in children. Antibiotic resistance rates and emm genotypes of GAS isolated from patients with acute pharyngitis were studied in 2009.
  93. ncbi Diagnosis of strep throat in adults: are clinical criteria really good enough?
    Alan L Bisno
    Department of Medicine, University of Miami School of Medicine and Veterans Affairs Medical Center, Miami, FL 33125, USA
    Clin Infect Dis 35:126-9. 2002
    The clinical manifestations of group A streptococcal and nonstreptococcal pharyngitis overlap quite broadly...
  94. ncbi Age-associated differences in prevalence of group A streptococcal type-specific M antibodies in children
    Preeti Jaggi
    Nationwide Children s Hospital, Ohio State University, 700 Children s Drive, Columbus, OH 43205, USA
    Eur J Pediatr 168:679-83. 2009
    Our prior studies of the molecular epidemiology of group A streptococcus (GAS) pharyngitis indicated that the most common emm types associated with pediatric pharyngitis in North America were 12, 1, 28, and 4...
  95. ncbi [Compliance rate of antibiotic therapy in patients with acute pharyngitis is very low, mainly when thrice-daily antibiotics are given]
    C Llor
    Centro de Salud Jaume I, Tarragona
    Rev Esp Quimioter 22:20-4. 2009
    To assess drug-compliance observed among patients with suspected streptococcal pharyngitis treated with twice-daily antibiotic regimens (b.i.d.) and others with thrice-daily regimens (t.i.d.).
  96. ncbi [Hydrological indications in the therapy of pharyngitis]
    Massimo Olina
    Clinica ORL, Universita del Piemonte Orientale, Novara
    Recenti Prog Med 99:314-21. 2008
    b>Pharyngitis is an inflammatory disease of the mucosal and submucosal structures of the throat. Infection may or may not be a component of the disease...
  97. ncbi Postoperative sore throat after elective surgical procedures
    Aliya Ahmed
    Department of Anaesthesia, Aga Khan University Hospital, Karachi, Pakistan
    J Ayub Med Coll Abbottabad 19:12-4. 2007
    ..Postoperative sore throat is a common complication of anaesthesia and can lead to dissatisfaction after surgery. Many factors can contribute to postoperative sore throat and the incidence varies with the method of airway management...
  98. ncbi Application of triamcinolone acetonide paste to the endotracheal tube reduces postoperative sore throat: a randomized controlled trial
    Sun Young Park
    Department of Anesthesiology and Pain Medicine, Soonchunhyang University Hospital, 657 Hannam Dong, Yongsan gu, Seoul 140 743, South Korea
    Can J Anaesth 58:436-42. 2011
    ....
  99. ncbi Pharyngitis in low-resources settings: a pragmatic clinical approach to reduce unnecessary antibiotic use
    Pierre Robert Smeesters
    Servico de Pediatria, Hospital Universitario de Brasilia, Universidade de Brasilia, Brasilia, Brazil
    Pediatrics 118:e1607-11. 2006
    Existing scoring systems for the diagnosis of group A streptococcus pharyngitis are insensitive or inapplicable in low-resources settings...
  100. ncbi Orally disintegrating olanzapine for the treatment of a manic patient with esophageal stricture plus chronic pharyngitis
    Yu Chih Shen
    Department of Psychiatry, Tzu Chi General Hospital, Hualien City, Taiwan, ROC
    Prog Neuropsychopharmacol Biol Psychiatry 31:541-2. 2007
    ..We describe a manic patient who has an esophageal stricture and chronic pharyngitis, two conditions that impede the swallowing of medications...
  101. ncbi Epidemiological characterization of Streptococcus pyogenes isolated from patients with multiple onsets of pharyngitis
    Taiji Ogawa
    Department of Oral and Molecular Microbiology, Osaka University Graduate School of Dentistry, Suita, Osaka, Japan
    FEMS Microbiol Lett 318:143-51. 2011
    ..causes a broad spectrum of acute infections and is the bacterium most frequently isolated from patients with pharyngitis. A number of antibiotics including penicillin have been shown to be effective, although antibiotic treatment ..

Research Grants62

  1. SpyA, a novel S. pyogenes ADP-ribosyltransferase
    STEPHEN L MOSELEY; Fiscal Year: 2010
    ..Infections due to this organism range from the relatively mild and common pharyngitis and impetigo to the acute and life-threatening necrotizing fasciitis and toxic shock...
  2. Group A Streptococcus responses to oxidative stress
    Ioannis Gryllos; Fiscal Year: 2010
    ..HEALTH RELEVANCE: Group A Streptococcus (Streptococcus pyogenes or GAS) is the leading cause of human bacterial pharyngitis, an infection state commonly referred to as 'strep throat', but it is also implicated in skin and ..
  3. Delineation of the molecular mechanisms underlying group A Streptococcus virulenc
    Paul Sumby; Fiscal Year: 2013
    ..The human bacterial pathogen group A Streptococcus (GAS) causes a broad spectrum of diseases, including pharyngitis, impetigo, and necrotizing fasciitis...
  4. Metal-dependent phosphohydrolase activity of CvfA from Streptococcus pyogenes
    GABRIELA CITLALLI PEREZ-ALVARADO; Fiscal Year: 2012
    ..A Streptococcus (GAS) is associated with a broad range of human diseases including scarlet fever, impetigo, pharyngitis, necrotizing fasciitis, streptococcal toxic shock syndrome and the post- streptococcal sequelae of rheumatic ..
  5. Tissue-Specific Infection by Group A Streptococci
    DEBRA BESSEN; Fiscal Year: 2009
    ..are mild and involve one of two tissues - the epithelial surface of the throat or skin - giving rise to pharyngitis or impetigo, respectively...
  6. Host-pathogen signaling in group A streptococcal infection
    Michael R Wessels; Fiscal Year: 2012
    ..The less severe but far more common syndromes of pharyngitis (streptococcal sore throat) and skin infections cause enormous morbidity and economic losses due to absenteeism ..
  7. Role of Immunogenetic Factors in Invasive Streptococcal Infections
    MALAK Y S KOTB; Fiscal Year: 2012
    ..same virulent GAS strain (M1T1) from STSS cases as wel as frommild GAS bacteremia cases or even cases with mild pharyngitis, we proposed that host factors may be playing an important role in potentiating the outcomes of GAS sepsis...
  8. CYTOLYSIN-MEDIATED TRANSLOCATION IN S. PYOGENES VIRULENC
    Michael G Caparon; Fiscal Year: 2013
    ..SLO is produced by Streptococcus pyogenes, an important cause of pharyngitis and other serious diseases including scarlet fever, rheumatic fever and necrotizing faciitis...
  9. Factors that influence susceptibility to acute streptococcal pharyngitis
    Patricia A Ryan; Fiscal Year: 2012
    ..by applicant): Group A streptococci infect through the upper respiratory tract mucosal surface and cause human pharyngitis ("Strep throat"), by first subverting clearance by the respiratory tract mucus and then attaching to the ..
  10. Vaccine and therapeutic antibodies against Group A Streptococcus
    Benfang Lei; Fiscal Year: 2013
    ..A Streptococcus (GAS) is a major human pathogen that causes a variety of diseases, including relatively mild pharyngitis and severe invasive infections, such as necrotizing fasciitis...
  11. CHEMISTRY AND IMMUNOLOGY OF STREPTOCOCCAL M PROTEINS
    James B Dale; Fiscal Year: 2010
    ..and bactericidal antibodies against clinical isolates of group A streptococci collected from children with pharyngitis in 10 geographic sites in the U.S...
  12. Evasion of Innate Immunity by Group A Streptococcus
    Benfang Lei; Fiscal Year: 2013
    ..A Streptococcus (GAS) is a major human pathogen that causes a variety of diseases, including relatively mild pharyngitis and skin infection and severe invasive infections such as sepsis and necrotizing fasciitis...
  13. INTERACTION OF GROUP A STREP WITH THE PLASMINOGEN SYSTEM
    Michael Boyle; Fiscal Year: 2001
    ..abstract): Group A streptococci are significant human pathogens associated with a variety of diseases including pharyngitis, impetigo, and invasive infections such as cellulitis and bacteremia...
  14. Heme Acquisition in Group A Streptococcus
    Benfang Lei; Fiscal Year: 2005
    ..pyogenes, commonly referred as Group A Streptococcus (GAS), is an important human pathogen causing pharyngitis, cellulitis, scarlet fever, necrotizing fasciitis, toxic shock syndrome, acute rheumatic fever, rheumatic heart ..
  15. DEFINITION OF THE CHRONIC EPSTEIN-BARR VIRUS SYNDROME
    James Jones; Fiscal Year: 1990
    ..To this end, patients who have had varying combinations of pharyngitis, lymphadenopathy, headache, fatigue, myalgia, arthralgia, neuralgia, paresthesis, depression and dyslogia for ..
  16. Analysis Of Group A Streptococcus-Saliva Interaction
    SAMUEL SHELBURNE; Fiscal Year: 2009
    ..despite knowing for 60 years that saliva is a major vector for the transmission of GAS from patients who have pharyngitis. Also, given that saliva coats the posterior pharynx, there is constant interplay between saliva and GAS during ..
  17. Streptococcal pharyngitis in slum versus non-slum communities in Salvador Brazil
    SARA TARTOF; Fiscal Year: 2007
    unreadable] DESCRIPTION (provided by applicant): Streptococcal pharyngitis is the acute disease that precedes the chronic disease process of rheumatic heart disease (RHD)...
  18. Small RNAs regulating group A Streptococcus virulence
    Paul Sumby; Fiscal Year: 2009
    The human bacterial pathogen group A Streptococcus (GAS) causes a broad spectrum of diseases, including pharyngitis, necrotizing fasciitis, and a toxic-shock-like syndrome...
  19. Prospective Study of 'PANDAS'
    Tanya Murphy; Fiscal Year: 2006
    ..Should clinical signs of pharyngitis develop, throat cultures will be ordered and, if positive for GAS, appropriate antibiotic treatment will be ..
  20. Minimizing Antibiotic Resistance in Colorado (MARC)
    Ralph Gonzales; Fiscal Year: 2004
    ..Specific Aim IB: Measure and assess changes in antibiotic prescription rates for pharyngitis in children, and bronchitis in adults, using commercial MCO and Medicaid administrative data from physician ..
  21. NEUROIMMONOLOGIC STUDIES OF CHRONIC FATIGUE SYNDROME
    Anthony Komaroff; Fiscal Year: 1992
    ..CFS is a cyclic chronic illness characterized by profound, disabling fatigue, fever, myalgias, arthralgias, pharyngitis, adenopathy, paresthesias, cognitive impairment and other symptoms...
  22. RECOMBINANT ANTIGEN TO DIAGNOSE INFECTIOUS MONONUCLEOSIS
    Patricia Busto; Fiscal Year: 1992
    ..The clinical diagnosis of IM relies upon the simultaneous presence of fever, pharyngitis, lymphocytosis with atypical lymphocytes and a positive serology...
  23. MOLECULAR PROPERTIES OF CLASS I AND II STREPTOCOCCI
    DEBRA BESSEN; Fiscal Year: 2000
    ..Recent studies have uncovered an organization that links different GABHS diseases (pharyngitis, impetigo, rheumatic fever) to the structure and function of emm genes, emm gene products, and emm-linked ..
  24. ABC TRANSPORTER IN GROUP A STREPTOCOCCUS
    CAMERON ASHBAUGH; Fiscal Year: 1999
    ..The spectrum of GAS disease includes pharyngitis, skin infections, life-threatening soft tissue infections, and the unique postinfectious complications of acute ..
  25. INTERACTION OF ORAL STREPTOCOCCI WITH ANIMAL TISSUES
    MURRAY STINSON; Fiscal Year: 2001
    ..glomerulonephritis (APSGN) is a non-suppurative complication of group A streptoccal infections (pharyngitis or pyoderma) often seen in children...
  26. Lactococcal vaccine for strep throat
    Bruce Geller; Fiscal Year: 2004
    ..The long-term goal of the project is to develop a safe, effective and economical vaccine against acute pharyngitis caused by group A streptococcal ("strep throat") infections...
  27. Trial to Reduce Antibiotic Use in A Primary Care PBRN
    David Bates; Fiscal Year: 2004
    ..importation of patients' problems, allergies, and medications; decision-support for the treatment of sinusitis, pharyngitis, and acute bronchitis; printable patient handouts about URIs, self-care, and antibiotics; and access to ..
  28. DOES PRIMARY CARE ACCESS DECREASE RESPIRATORY ED VISITS?
    Robert Lowe; Fiscal Year: 1999
    ..by an earlier visit to a traditional primary care setting, and for upper respiratory tract infections, pharyngitis, acute bronchitis, and otitis media, which might have been handled more appropriately in a traditional primary ..
  29. Role of Group A Streptococcal toxins in bacterial internalization and survival
    LAUREN LOGSDON; Fiscal Year: 2009
    ..internalization may explain the high rate of carriers, who possess GAS in their pharynx but do not develop pharyngitis. The experiments designed here set out to understand how the secreted toxins of GAS promote bacterial survival ..
  30. CTL RESPONSE IN ACUTE HIV INFECTION
    Joia Mukherjee; Fiscal Year: 2001
    ..majority of persons will develop an infectious mono- like syndrome with variable combinations of fever, rash, pharyngitis, oral and genital ulcers...
  31. DEVELOPMENT OF A GROUP A STREP SUBUNIT VACCINE
    Dennis Hruby; Fiscal Year: 1999
    The objective of the current study is to develop a prototype vaccine for the prevention of group A streptococcal pharyngitis. Group A streptococci (GAS) cause a variety of suppurative infections in humans, with, conservatively, 20 ..
  32. Role of eukaryotic-type STK and PPPL in GAS pathogenesis
    Vijay Pancholi; Fiscal Year: 2006
    Group A Streptococcus (GAS, S. pyogenes) causes a variety of human diseases ranging from mild pharyngitis and skin diseases to severe necrotizing fasciits, toxic shock syndrome, and autoimmune diseases...
  33. Measuring Quality - The Impact of Patient Complexity
    Robert Centor; Fiscal Year: 2007
    ..Finally, we hope to present an economical research agenda to the research community and AHRQ at the national meeting. [unreadable] [unreadable] [unreadable]..
  34. STREPTOCOCCAL INACTIVATOR IN HUMAN CHEMOATTRACTANTS
    Paul Cleary; Fiscal Year: 2006
    ..New data indicates that the C5a peptide required for successful colonization and persistence of streptococci in nasal associated lymphoid tissue. ..
  35. Srv is critical for Streptococcal survival in the host
    SEAN REID; Fiscal Year: 2009
    ..Understanding the mechanism of Srv-dependent gene regulation will provide new insights into the control of GAS disease. ..
  36. GROUP A STREPTOCOCCAL INFECTIONS IN CHILDREN
    Judith Martin; Fiscal Year: 2004
    ..is a longitudinal cohort study of school-aged children to define the epidemiology of group A streptococcal pharyngitis. Students in grades K through 8 will be enrolled and throat cultures obtained twice monthly and with each ..
  37. T cell immune response to group A streptococci in NALT
    Paul Cleary; Fiscal Year: 2008
    Five million people are annually diagnosed with streptococcal pharyngitis, and 1200-1500 die annually from complications of group A streptococcal (GAS) infections in the United States alone...
  38. INTRACELLULAR INFECTION BY INVASIVE GROUP A STREPTOCOCCI
    Paul Cleary; Fiscal Year: 2006
    ..Information gained from this study may identify new targets for antibiotic development, and increase our understanding of the mechanisms by which this pathogen persists in human populations. ..
  39. ACTIVITY INTERVENTION FOR CHRONIC FATIGUE SYNDROME
    LEONARD JASON; Fiscal Year: 2004
    ....
  40. Spirituality and Will to Live in Patients with HIV/AIDS
    Joel Tsevat; Fiscal Year: 2004
    ..We anticipate that such information will be of great benefit to patients with HIV/AIDS in their quest to make the best of a potentially devastating illness. ..
  41. LEUKOTRIENE POLYMORPHISMS & MONTELUKAST RESPONSE
    John Lima; Fiscal Year: 2003
    ..This information may lead to individualization of asthma medications based on the genetic make-up of the patient. ..
  42. Epidemiology of an uropathogenic E coli clonal group
    Lee Riley; Fiscal Year: 2003
    ..coli can be spread by contaminated ingestible vehicles, and use the data generated from this project to design long-term studies to better characterize risk factors associated with CgA infection. ..
  43. EVOLUTION OF GROUP A STREPTOCOCCI
    DEBRA BESSEN; Fiscal Year: 2004
    ..These sera will be tested to determine whether strain structure is determined by the immunogenicity of the emm and sof gene products. ..
  44. Therapeutic vaccine against tuberculosis
    Lee Riley; Fiscal Year: 2006
    ..Therapeutic vaccines against TB is a major priority in TB control, and we have an opportunity to identify such products by a novel approach using a simple, inexpensive, and reproducible animal model. ..
  45. ABSTINENT SOCIAL SUPPORT IN OXFORD HOUSE
    LEONARD JASON; Fiscal Year: 2005
    ..e., abstinence status, reduction in symptoms, and quantity of use); and, 2) to examine whether changes in the degree of abstinence support received, moderated by social investment, promote these increases in self-efficacy. ..
  46. Tissue-Specific Infection by Group A Streptococci
    DEBRA BESSEN; Fiscal Year: 2007
    ..A better understanding of the molecular basis for throat- and skin-specific infection might aid in the development of vaccines which target essential adaptive traits and thereby, break the chain of transmission. ..
  47. Risk Factrors Associated with CFS and CF Prognosis
    LEONARD JASON; Fiscal Year: 2007
    ..abstract_text> ..
  48. THE EFFECTS OF LAWS ON YOUTH PREVALENCE
    LEONARD JASON; Fiscal Year: 2005
    ..If these predicted findings do emerge, they will have an important influence on the ways in which public policy officials and community members consider interventions directed at lowering rates of smoking among their youth. ..
  49. Strategies for Group A Streptococcal Prevention
    Grace Lee; Fiscal Year: 2008
    unreadable] DESCRIPTION (provided by the applicant): Pharyngitis accounts for 6.4% of office visits and 10% of total antibiotic prescriptions in the U.S...
  50. Obstacles to Answering Physicians' Patient-Care Question
    John Ely; Fiscal Year: 2003
    ..Benefit: By identifying areas where knowledge resources fail to meet the needs of physicians, we will provide recommendations to help knowledge base developers better meet those needs. ..
  51. Variable Proteins of Diversity-generating Retroelements
    Partho Ghosh; Fiscal Year: 2010
    ..Our project is aimed at providing basic knowledge on how these variable bacterial proteins recognize diverse targets, with the expectation that this knowledge will have practical applications. ..
  52. Evaluating a Bilingual Voluntary Community-Based Healthcare Organization
    Leonard A Jason; Fiscal Year: 2010
    ..An experimental design will analyze whether English-language dominant Hispanics with higher vs. lower American acculturation will have better outcomes in Traditional Oxford House aftercare. ..
  53. Protein Translocation by the Type III Secretion System
    Partho Ghosh; Fiscal Year: 2010
    ..Our proposal is aimed at understanding how this injection process occurs, and results from our studies are likely to be valuable in the design of antimicrobial strategies aimed at combating these pathogens. ..
  54. Molecular Evolution of Resistance in Strep. pyogenes
    DEBRA BESSEN; Fiscal Year: 2005
    ..pyogenes) are highly prevalent bacterial pathogens that infect the throat or skin of humans, causing pharyngitis or impetigo...
  55. PHARMACOGENETICS OF ASTHMA MONOTHERAPY
    John Lima; Fiscal Year: 2005
    ..The results of this pharmacogenetic study may facilitate the optimal selection of monotherapy in asthma. ..
  56. Structure of the multidrug efflux protein AcrA
    Partho Ghosh; Fiscal Year: 2006
    ..These short-term goals will enable the design of inhibitors of RND efflux pumps, which have the potential of rendering useful many antibiotics that have become clinically ineffective. [unreadable] [unreadable]..
  57. Reflux Disease in Patients with Throat Signs/Symptoms
    Michael Vaezi; Fiscal Year: 2005
    ..These methods will be employed pre- and post-therapy on all patients to assess their potential clinical utility, especially in those unresponsive to medical therapy after aggressive acid suppression. ..
  58. University of Cincinnati CTSA Planning Grant
    Joel Tsevat; Fiscal Year: 2006
    ..We anticipate that the Institutional CTSA process will transform the way that clinical and translational science and training is carried out both locally and nationally. [unreadable] [unreadable] [unreadable]..
  59. Oral Care and Respiratory Pathogen Colonization
    Ozan Akca; Fiscal Year: 2004
    ..Reducing respiratory pathogen colonization in the mouth could significantly reduce the morbidity and cost of VAP. ..
  60. Global GAS Vaccine Based On The M-Protein
    Michael Good; Fiscal Year: 2008
    ..is a Gram positive bacterial pathogen that is responsible for numerous diseases including relatively benign pharyngitis and skin infections to serious invasive diseases including necrotizing fasciitis and the post-infectious ..
  61. Mechanism of Host Cell Invasion by Microbial Pathogens
    Partho Ghosh; Fiscal Year: 2010
    ..In addition, the particular pathogen we are studying, Listeria monocytogenes, affects a protein called Met that is involved in some cancers. Thus, results from our studies may also have an impact on cancer therapies. ..
  62. Periodontal Host-Pathogen Conference
    Frank Scannapieco; Fiscal Year: 2004
    ..We will offer a limited number of travel grants to several graduate student or post-doctoral fellow poster presenters who have need for such support. ..