pneumocystis pneumonia

Summary

Summary: A pulmonary disease in humans occurring in immunodeficient or malnourished patients or infants, characterized by DYSPNEA, tachypnea, and HYPOXEMIA. Pneumocystis pneumonia is a frequently seen opportunistic infection in AIDS. It is caused by the fungus PNEUMOCYSTIS JIROVECI. The disease is also found in other MAMMALS where it is caused by related species of Pneumocystis.

Top Publications

  1. ncbi Development and evaluation of a real-time PCR assay for detection of Pneumocystis jirovecii DNA in bronchoalveolar lavage fluid of HIV-infected patients
    J F Huggett
    Centre for Infectious Diseases and International Health, Windeyer Institute for Medical Sciences, University College London, London, UK
    Thorax 63:154-9. 2008
  2. pmc Exposure of immunocompetent adult mice to Pneumocystis carinii f. sp. muris by cohousing: growth of P. carinii f. sp. muris and host immune response
    Chun Li An
    Trudeau Institute, Saranac Lake, NY 12983, USA
    Infect Immun 71:2065-70. 2003
  3. ncbi Incidence of acquired immunodeficiency syndrome-associated opportunistic diseases and the effect of treatment on a cohort of 1115 patients infected with human immunodeficiency virus, 1989-1997
    Francisco Javier San-Andrés
    Medicina Familiar y Comunitaria, Centro de Salud Potes, Guadalajara 19003, Spain
    Clin Infect Dis 36:1177-85. 2003
  4. ncbi Pneumocystis pneumonia in South African children with and without human immunodeficiency virus infection in the era of highly active antiretroviral therapy
    Brenda M Morrow
    Department of Paediatics and Child Health, University of Cape Town, Cape Town, South Africa
    Pediatr Infect Dis J 29:535-9. 2010
  5. ncbi Opportunistic infections in patients with and patients without Acquired Immunodeficiency Syndrome
    Kent A Sepkowitz
    Memorial Sloan Kettering Cancer Center, New York, NY, 10021, USA
    Clin Infect Dis 34:1098-107. 2002
  6. ncbi Clinical presentation and outcome of Pneumocystis carinii pneumonia in Malawian children
    S M Graham
    Department of Paediatrics, College of Medicine, University of Malawi, Blantyre
    Lancet 355:369-73. 2000
  7. pmc Predicting mortality from HIV-associated Pneumocystis pneumonia at illness presentation: an observational cohort study
    M W Fei
    Division of Pulmonary and Critical Care Medicine, San Francisco General Hospital, University of California, San Francisco, San Francisco, California 94110, USA
    Thorax 64:1070-6. 2009
  8. pmc Echinocandin treatment of pneumocystis pneumonia in rodent models depletes cysts leaving trophic burdens that cannot transmit the infection
    Melanie T Cushion
    College of Medicine, University of Cincinnati, Cincinnati, Ohio, United States of America
    PLoS ONE 5:e8524. 2010
  9. ncbi Serum indicators for the diagnosis of pneumocystis pneumonia
    Sadatomo Tasaka
    Division of Pulmonary Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Chest 131:1173-80. 2007
  10. ncbi The high burden of Pneumocystis carinii pneumonia in African HIV-1-infected children hospitalized for severe pneumonia
    Donatella D Ruffini
    Department of Paediatrics, University of the Witwatersrand, Johannesburg 2000, South Africa
    AIDS 16:105-12. 2002

Research Grants

  1. Modulation of host immune defense by Pneumocystis beta-glucans
    EVA MARIA CARMONA PORQUERA; Fiscal Year: 2013
  2. Identification of new compounds against fungal microbes
    Maurizio Del Poeta; Fiscal Year: 2013
  3. Immune response to Pneumocystis and bone marrow failure
    Nicole Meissner; Fiscal Year: 2013
  4. Pneumocystis carinii: Macrophage &Epithelial Activation
    Andrew H Limper; Fiscal Year: 2013
  5. Patient-Oriented Research and Mentoring in Pneumocystis
    Laurence Huang; Fiscal Year: 2010
  6. Eosinophils and lung immunity to Pneumocystis
    Chad Steele; Fiscal Year: 2013
  7. Role of B cells in host defense against Pneumocystis
    Beth A Garvy; Fiscal Year: 2012
  8. STAT4 mediated immunity to Pneumocystis
    Chad Steele; Fiscal Year: 2012
  9. T cells and P carinii Pneumonia
    Jay K Kolls; Fiscal Year: 2013
  10. Host response to P. carinii in neonatal mice
    Beth A Garvy; Fiscal Year: 2013

Detail Information

Publications253 found, 100 shown here

  1. ncbi Development and evaluation of a real-time PCR assay for detection of Pneumocystis jirovecii DNA in bronchoalveolar lavage fluid of HIV-infected patients
    J F Huggett
    Centre for Infectious Diseases and International Health, Windeyer Institute for Medical Sciences, University College London, London, UK
    Thorax 63:154-9. 2008
    b>Pneumocystis pneumonia (PCP) is conventionally diagnosed by identifying Pneumocystis jirovecii in lower respiratory tract samples using cytochemical stains. Molecular diagnosis of PCP is potentially more sensitive.
  2. pmc Exposure of immunocompetent adult mice to Pneumocystis carinii f. sp. muris by cohousing: growth of P. carinii f. sp. muris and host immune response
    Chun Li An
    Trudeau Institute, Saranac Lake, NY 12983, USA
    Infect Immun 71:2065-70. 2003
    ..Once an acquired immune response was initiated, the P. carinii f. sp. muris organisms were quickly eliminated without clinical signs of disease...
  3. ncbi Incidence of acquired immunodeficiency syndrome-associated opportunistic diseases and the effect of treatment on a cohort of 1115 patients infected with human immunodeficiency virus, 1989-1997
    Francisco Javier San-Andrés
    Medicina Familiar y Comunitaria, Centro de Salud Potes, Guadalajara 19003, Spain
    Clin Infect Dis 36:1177-85. 2003
    ..A reduction in the incidence of AIDS-related ODs was observed, mainly in patients who underwent prophylaxis. Adherence to antiretroviral treatment and PCP prophylaxis was associated with a reduction in the risk of disease...
  4. ncbi Pneumocystis pneumonia in South African children with and without human immunodeficiency virus infection in the era of highly active antiretroviral therapy
    Brenda M Morrow
    Department of Paediatics and Child Health, University of Cape Town, Cape Town, South Africa
    Pediatr Infect Dis J 29:535-9. 2010
    b>Pneumocystis pneumonia (PCP) is a major cause of hospitalization and mortality in human immunodeficiency virus (HIV)-infected African children.
  5. ncbi Opportunistic infections in patients with and patients without Acquired Immunodeficiency Syndrome
    Kent A Sepkowitz
    Memorial Sloan Kettering Cancer Center, New York, NY, 10021, USA
    Clin Infect Dis 34:1098-107. 2002
    ..Reviewed are 4 common opportunistic infections: Pneumocystis carinii pneumonia, cryptococcosis, atypical mycobacterial infection, and cytomegalovirus infection. Emphasized are the important differences among these groups at risk...
  6. ncbi Clinical presentation and outcome of Pneumocystis carinii pneumonia in Malawian children
    S M Graham
    Department of Paediatrics, College of Medicine, University of Malawi, Blantyre
    Lancet 355:369-73. 2000
    ..We aimed to describe the rate, clinical presentation, and outcome of PCP in young Malawian children with acute severe pneumonia...
  7. pmc Predicting mortality from HIV-associated Pneumocystis pneumonia at illness presentation: an observational cohort study
    M W Fei
    Division of Pulmonary and Critical Care Medicine, San Francisco General Hospital, University of California, San Francisco, San Francisco, California 94110, USA
    Thorax 64:1070-6. 2009
    Although the use of antiretroviral therapy has led to dramatic declines in AIDS-associated mortality, Pneumocystis pneumonia (PCP) remains a leading cause of death in HIV-infected patients.
  8. pmc Echinocandin treatment of pneumocystis pneumonia in rodent models depletes cysts leaving trophic burdens that cannot transmit the infection
    Melanie T Cushion
    College of Medicine, University of Cincinnati, Cincinnati, Ohio, United States of America
    PLoS ONE 5:e8524. 2010
    ..Importantly, the echinocandins provide novel and powerful chemical tools to probe the still poorly understood bi-phasic life cycle of this genus of fungal pathogens...
  9. ncbi Serum indicators for the diagnosis of pneumocystis pneumonia
    Sadatomo Tasaka
    Division of Pulmonary Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Chest 131:1173-80. 2007
    The diagnosis of pneumocystis pneumonia (PCP) is difficult because it requires microscopic examination to identify pneumocystis from induced sputum or BAL fluid.
  10. ncbi The high burden of Pneumocystis carinii pneumonia in African HIV-1-infected children hospitalized for severe pneumonia
    Donatella D Ruffini
    Department of Paediatrics, University of the Witwatersrand, Johannesburg 2000, South Africa
    AIDS 16:105-12. 2002
    ..To evaluate the burden of Pneumocystis carinii pneumonia (PCP) and the usefulness of induced sputum and nasopharyngeal aspirates (NPA) in diagnosing PCP in African children in whom the use of bronchoalveolar lavage is unavailable...
  11. ncbi Development of a loop-mediated isothermal amplification method for diagnosing Pneumocystis pneumonia
    Natsu Uemura
    Teikyo University Institute of Medical Mycology, 539 Otsuka, Hachioji, Tokyo 192 0395, Japan
    J Med Microbiol 57:50-7. 2008
    ..In this study a LAMP assay for diagnosing Pneumocystis pneumonia (PCP) was developed...
  12. pmc Downregulation of PU.1 leads to decreased expression of Dectin-1 in alveolar macrophages during Pneumocystis pneumonia
    Chen Zhang
    Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Infect Immun 78:1058-65. 2010
    ..Results of this study indicate that downregulation of PU.1 during Pneumocystis pneumonia leads to decreased expression of Dectin-1 in AMs.
  13. ncbi Noninvasive ventilation for treating acute respiratory failure in AIDS patients with Pneumocystis carinii pneumonia
    Marco Confalonieri
    Struttura Complessa Pneumologia, Azienda Ospedaliera di Trieste, U O Pneumologia, via Bonomea 265, 34100 Trieste, Italy
    Intensive Care Med 28:1233-8. 2002
    ..To compare noninvasive positive pressure ventilation (NPPV) vs. invasive mechanical ventilation in AIDS patients with Pneumocystis carinii pneumonia (PCP)-related acute respiratory failure (ARF)...
  14. pmc Critical care management and outcome of severe Pneumocystis pneumonia in patients with and without HIV infection
    Xavier Monnet
    AP HP, Hopital de Bicetre, Service de Reanimation Medicale, 78, rue du General Leclerc, Le Kremlin Bicetre, F 94270, France
    Crit Care 12:R28. 2008
    ..Improved knowledge about the differential characteristics and management modalities could guide treatment based on HIV status...
  15. pmc High prevalence of dihydropteroate synthase mutations in Pneumocystis jirovecii isolated from patients with Pneumocystis pneumonia in South Africa
    Leigh Dini
    Department of Parasitology, Mycology, and Environmental Microbiology, Swedish Institute for Infectious Disease Control, Solna, Sweden
    J Clin Microbiol 48:2016-21. 2010
    ....
  16. ncbi Causes of lower respiratory infection in HIV-infected Ugandan adults who are sputum AFB smear-negative
    W Worodria
    Department of Medicine, Makerere University, Mulago Hospital, Kampala, Uganda
    Int J Tuberc Lung Dis 7:117-23. 2003
    ..Mulago national referral and teaching hospital...
  17. ncbi Pneumocystis carinii mutations are associated with duration of sulfa or sulfone prophylaxis exposure in AIDS patients
    P Kazanjian
    Division of Infectious Diseases, Dept of Medicine, University of Michigan Health System, Ann Arbor, MI 48109 0378, USA
    J Infect Dis 182:551-7. 2000
    ..1; P=0.01). Thus, an increased duration of sulfa or sulfone prophylaxis increases the chance of developing a P. carinii mutation. The majority of patients with mutations respond to sulfa or sulfone therapy...
  18. ncbi Clinical and radiological features of Pneumocystis pneumonia in patients with rheumatoid arthritis, in comparison with methotrexate pneumonitis and Pneumocystis pneumonia in acquired immunodeficiency syndrome: a multicenter study
    Hitoshi Tokuda
    Department of Internal Medicine, Social Health Insurance Central General Hospital, Tokyo
    Intern Med 47:915-23. 2008
    To elucidate the clinical and radiological features of Pneumocystis pneumonia (PCP) in patients with rheumatoid arthritis (RA), compared with methotrexate (MTX) pneumonitis in RA and Pneumocystis pneumonia in acquired immunodeficiency ..
  19. ncbi Analysis of underlying diseases and prognosis factors associated with Pneumocystis carinii pneumonia in immunocompromised HIV-negative patients
    F Roblot
    Infectious Diseases Unit, Department of Internal Medicine, La Miletrie, University Hospital, 86021 Poitiers Cedex, France
    Eur J Clin Microbiol Infect Dis 21:523-31. 2002
    ..The diagnosis of PCP should be considered more frequently and advocated earlier in immunocompromised HIV-negative patients, since prompt diagnosis may improve the prognosis of these patients...
  20. ncbi Ineffectiveness of trimethoprim-sulfamethoxazole prophylaxis and the importance of bacterial and viral coinfections in African children with Pneumocystis carinii pneumonia
    Shabir A Madhi
    National Health Laboratory Service University of the Witwatersrand Medical Research Council Respiratory and Meningeal Pathogens Research Unit, Wits Health Consortium, Johannesburg, South Africa
    Clin Infect Dis 35:1120-6. 2002
    ..Concurrent P. carinii infection was observed in 6 of 18, 11 of 26, and 4 of 6 HIV-1-infected children who had bacteremia, a respiratory virus isolated, or Mycobacterium species isolated, respectively...
  21. ncbi Delayed clearance of pneumocystis carinii infection, increased inflammation, and altered nitric oxide metabolism in lungs of surfactant protein-D knockout mice
    Elena N Atochina
    Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6061, USA
    J Infect Dis 189:1528-39. 2004
    ..These results indicate that SP-D plays a role in host defense against P. carinii in vivo by modulating clearance of organisms, lung inflammation, and metabolism of NO...
  22. pmc Evaluation of diagnostic value and epidemiological implications of PCR for Pneumocystis carinii in different immunosuppressed and immunocompetent patient groups
    A Sing
    Max von Pettenkofer Institut fur Hygiene und Medizinische Mikrobiologie, Ludwig Maximilians Universitat Munchen, 80336 Munich, Germany
    J Clin Microbiol 38:1461-7. 2000
    ..However, nested PCR identified a significant percentage of clinically silent P. carinii colonizations in about 17 to 20% of immunocompetent and immunosuppressed non-HIV patients...
  23. ncbi Neonatal T cells in an adult lung environment are competent to resolve Pneumocystis carinii pneumonia
    M H Qureshi
    Departments of Internal Medicine, Microbiology, and Immunology, Division of Infectious Diseases, University of Kentucky and Veterans Administration Medical Center, Lexington, KY 40506, USA
    J Immunol 166:5704-11. 2001
    ..carinii infection when harbored in an adult lung environment, suggesting that the neonatal lung environment, and not the T cells, is ineffective at responding to P. carinii infection...
  24. pmc Rapid detection of Pneumocystis carinii in bronchoalveolar lavage specimens from human immunodeficiency virus-infected patients: use of a simple DNA extraction procedure and nested PCR
    M Rabodonirina
    Departement de Parasitologie et de Mycologie, Universite Claude Bernard, Lyon, France
    J Clin Microbiol 35:2748-51. 1997
    ..This colonization is not of clinical importance but is of epidemiological importance. Our rapid, simple, and sensitive amplification protocol may be performed in clinical laboratories for the routine diagnosis of PCP with BAL specimens...
  25. ncbi Polymerase chain reaction for diagnosing pneumocystis pneumonia in non-HIV immunocompromised patients with pulmonary infiltrates
    Elie Azoulay
    Service de Reanimation Medicale, Hopital Saint Louis, 1 avenue Claude Vellefaux, Paris, France
    Chest 135:655-61. 2009
    ..Pneumocystis jiroveci polymerase chain reaction (PCR) has higher sensitivity than conventional stains but cannot distinguish colonization from infection...
  26. ncbi Mutations in the dihydropteroate synthase gene of human-derived Pneumocystis carinii isolates from Italy are infrequent but correlate with prior sulfa prophylaxis
    Liang Ma
    Critical Care Medicine Department, Warren Grant Magnuson Clinical Center, National Institutes of Health, Bethesda, Maryland 20892 1662, USA
    J Infect Dis 185:1530-2. 2002
    ..The study confirms the association between DHPS mutations and prior sulfa prophylaxis and shows that the prevalence of DHPS mutations in an Italian patient population is lower than that in other populations...
  27. ncbi Bronchoalveolar lavage fluid cytology in patients with Pneumocystis carinii pneumonia
    J A Jacobs
    Departments of Medical Microbiology and Pulmonology, University Hospital Maastricht, P O Box 5800, 6202 AZ Maastricht, The Netherlands
    Acta Cytol 45:317-26. 2001
    ..To evaluate bronchoalveolar lavage (BAL) cytology and organism burden in patients with Pneumocystis carinii pneumonia (PCP) who were infected with the human immunodeficiency virus (HIV) and in those with other immunodeficiencies...
  28. ncbi Pneumocystis carinii pneumonia in critically ill patients with malignancy: a descriptive study
    J R Zahar
    Intensive Care Department, Institut Gustave Roussy, Paris, France
    Clin Infect Dis 35:929-34. 2002
    ..9). Studies are needed to determine whether aggressive monitoring and treatment of patients with >15% neutrophils in BAL fluid specimens can improve the outcome of critically ill patients with malignancy and PCP...
  29. ncbi Differences and similarities of cytomegalovirus and pneumocystis pneumonia in HIV-negative immunocompromised patients thin section CT morphology in the early phase of the disease
    M N Vogel
    Department of Diagnostic Radiology, Eberhard Karls University, Hoppe Seyler Str 3, 72076 Tubingen, Germany
    Br J Radiol 80:516-23. 2007
    The purpose of this study was to assess CT morphology of pneumocystis pneumonia (PcP) and cytomegalovirus (CMV) pneumonia for specific characteristic features, similarities as well as differences, which might contribute to an early ..
  30. ncbi Severe Pneumocystis pneumonia in a renal transplant recipient after long term mycophenolate mofetil treatment
    Anne Totet
    Rev Inst Med Trop Sao Paulo 47:303-4; author reply 305. 2005
  31. ncbi Respiratory diseases in the first year of life in children born to HIV-1-infected women
    M Kattan
    Department of Pediatrics, Mount Sinai School of Medicine, New York, New York 10029, USA
    Pediatr Pulmonol 31:267-76. 2001
    ..Chest X-ray abnormalities and tachypnea suggest that subacute disease is present in infected infants. Further follow-up is warranted to determine its nature...
  32. pmc Current epidemiology of Pneumocystis pneumonia
    Alison Morris
    University of Southern California, Los Angeles, California, USA
    Emerg Infect Dis 10:1713-20. 2004
    b>Pneumocystis pneumonia (PCP) has historically been one of the leading causes of disease among persons with AIDS...
  33. ncbi Pneumocystis carinii pneumonia recurrence in HIV patients on highly active antiretroviral therapy: secondary prophylaxis
    S Abgrall
    Institut National de la Santé et de la Recherche Médicale INSERM SC4, Paris, France
    J Acquir Immune Defic Syndr 26:151-8. 2001
    ..95; p <.0001) was associated with recurrence, whereas higher CD4+ cell counts during follow-up (RH, 0.39/50 x 106/L increment; p <.002) were protective...
  34. ncbi Polyamine-mediated apoptosis of alveolar macrophages during Pneumocystis pneumonia
    Mark E Lasbury
    Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    J Biol Chem 282:11009-20. 2007
    The number of alveolar macrophages is decreased during Pneumocystis pneumonia (Pcp), partly because of activation of apoptosis in these cells. This apoptosis occurs in both rat and mouse models of Pcp...
  35. ncbi Pneumocystis jiroveci genotypes in the Spanish population
    M A Montes-Cano
    Department of Internal Medicine, Virgen del Rocio University Hospital, Seville, Spain
    Clin Infect Dis 39:123-8. 2004
    ..The analysis of DHPS genotypes assesses the prevalence of its 4 possible genotypes, with 35.5% of genotypes related to sulfa resistance. The data suggest a common source of infection between both groups...
  36. ncbi Clindamycin-primaquine versus pentamidine for the second-line treatment of pneumocystis pneumonia
    Tark Kim
    Department of Infectious Diseases, Asan Medical Center, 388 1 Pungnap 2dong, Songpa Gu, Seoul 138 736, Korea
    J Infect Chemother 15:343-6. 2009
    There are limited data on the efficacy of alternative regimens for treating patients with pneumocystis pneumonia (PCP). We compared the efficacy of clindamycin-primaquine (C-P) with that of pentamidine as a second line treatment for PCP...
  37. ncbi Quantification and spread of Pneumocystis jirovecii in the surrounding air of patients with Pneumocystis pneumonia
    Firas Choukri
    Saint Louis Hospital APHP, Paris Diderot University, Paris, France
    Clin Infect Dis 51:259-65. 2010
    ..Our objective is to evaluate P. jirovecii air diffusion in patients with Pneumocystis pneumonia.
  38. pmc Anti-CD3 antibody decreases inflammation and improves outcome in a murine model of Pneumocystis pneumonia
    Samir P Bhagwat
    Department of Pediatrics, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    J Immunol 184:497-502. 2010
    ..Thus, the anti-human CD3 monoclonal Ab OKT3, which is already in clinical use, has the potential to be developed as an adjunctive therapy for PcP...
  39. ncbi IFN-gamma deficiency worsen Pneumocystis pneumonia with Th17 development in nude mice
    Tao Hu
    Department of Infection and Host Defense, Shinshu University Graduate School of Medicine, Asahi 3 1 1, Matsumoto 390 8621, Japan
    Immunol Lett 127:55-9. 2009
    b>Pneumocystis pneumonia (PCP) occurs frequently in patients with immunodeficiency syndromes, especially AIDS...
  40. pmc Effects of decreased calmodulin protein on the survival mechanisms of alveolar macrophages during Pneumocystis pneumonia
    Mark E Lasbury
    Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, 46202 5112, USA
    Infect Immun 77:3344-54. 2009
    ..Ubiquitous calcium-sensing protein calmodulin protein and mRNA levels were also reduced in Amø during Pneumocystis pneumonia (Pcp)...
  41. ncbi Pneumocystis jiroveci pneumonia in patients with rheumatoid arthritis treated with infliximab: a retrospective review and case-control study of 21 patients
    Yukiko Komano
    Tokyo Medical and Dental University, Tokyo, Japan
    Arthritis Rheum 61:305-12. 2009
    ..To establish proper management of Pneumocystis jiroveci pneumonia (PCP) in rheumatoid arthritis (RA) patients treated with infliximab. PCP has been observed in 0.4% of patients with RA treated with infliximab in Japan...
  42. pmc Outcome of HIV-associated Pneumocystis pneumonia in hospitalized patients from 2000 through 2003
    Saba Radhi
    Department of Medicine, Division of Pulmonary and Critical Care Medicine and the Will Rogers Institute Pulmonary Research Center, University of Southern California, Los Angeles, CA, USA
    BMC Infect Dis 8:118. 2008
    b>Pneumocystis pneumonia (PCP) remains a leading cause of morbidity and mortality in HIV-infected persons...
  43. ncbi Cytokine profiles of bronchoalveolar lavage fluid in patients with pneumocystis pneumonia
    Sadatomo Tasaka
    Division of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Microbiol Immunol 54:425-33. 2010
    ..The modest upregulation of IL-8 and IL-6 might be associated with the milder clinical manifestations of PCP in AIDS patients...
  44. pmc Detection of Pneumocystis carinii DNA in blood specimens from human immunodeficiency virus-infected patients by nested PCR
    M Rabodonirina
    Departement de Parasitologie et de Mycologie, Universite Claude Bernard, Lyon, France
    J Clin Microbiol 37:127-31. 1999
    ..In conclusion, P. carinii DNA may be detected in whole blood from HIV-infected patients, but the nature and the meaning of the circulating form of P. carinii remain to be established...
  45. ncbi Pneumocystis carinii pneumonia and cytomegalovirus infection in children with vertically acquired HIV infection
    A J Williams
    Department of Epidemiology and Public Health, Institute of Child Health, London, UK
    AIDS 15:335-9. 2001
    ..Breast-feeding increases the risk of combined PCP and CMV infection, which is associated with severe disease...
  46. ncbi Corticosteroids as adjunctive therapy for severe Pneumocystis carinii pneumonia in non-human immunodeficiency virus-infected patients: retrospective study of 31 patients
    C Delclaux
    Service de Reanimation Medicale, Hopital Henri Mondor, Creteil, France
    Clin Infect Dis 29:670-2. 1999
    ....
  47. ncbi Detection of Pneumocystis jirovecii dihydropteroate synthase polymorphisms in patients with Pneumocystis pneumonia
    M C Costa
    Unidade de Protozoários Oportunistas VIH e Outras Protozooses, Unidade de Parasitologia e Microbiologia Médicas UPMM, Instituto de Higiene e Medicina Tropical, Lisboa, Portugal
    Scand J Infect Dis 37:766-71. 2005
    ..jirovecii DHPS polymorphisms and clinical resistance to sulfa drugs...
  48. ncbi Pneumocystis infections: the iceberg?
    E Dei-Cas
    Dept Microbiology of Ecosystems, Pasteur Institute of Lille, Lille and Faculty of Medicine and Regional University Hospital Centre, France
    Med Mycol 38:23-32. 2000
    ..In fact, airborne Pneumocystis infection can display a large spectrum of clinical presentations and most likely, we recognize at present only the tip of the iceberg...
  49. ncbi Evaluation of Pneumocystis pneumonia infection risk factors in patients with connective tissue disease
    Noriko Iikuni
    Institute of Rheumatology, Tokyo Women s Medical University, 10 22 Kawada cho, Shinjuku ku, Tokyo, 162 0054, Japan
    Mod Rheumatol 16:282-8. 2006
    ..lavage fluid Pneumocystis polymerase chain reaction (PC-PCR) and analyzed the risk factors that cause Pneumocystis pneumonia (PCP) susceptibility and fatality...
  50. ncbi Mutations in dihydropteroate synthase gene of Pneumocystis carinii in HIV patients with Pneumocystis carinii pneumonia
    E Visconti
    Department of Infectious Diseases, , Largo F. Vito, 1 00168, Rome, Italy
    Int J Antimicrob Agents 18:547-51. 2001
    ..carinii pneumonia (PCP) were successfully treated with sulpha drugs. We think that P. carinii drug-resistance could be an emerging problem for immunocompromised patients including those with HIV infection...
  51. pmc Interleukin-12 and host defense against murine Pneumocystis pneumonia
    Sanbao Ruan
    Section of Pulmonary Critical Care Medicine, LSU Health Sciences Center, New Orleans, LA 70112, USA
    Infect Immun 76:2130-7. 2008
    Little is known about the role of the cytokine interleukin-12 (IL-12) in Pneumocystis pneumonia or its potential use as immunotherapy...
  52. pmc Relationship between mutations in dihydropteroate synthase of Pneumocystis carinii f. sp. hominis isolates in Japan and resistance to sulfonamide therapy
    T Takahashi
    Departments of Infectious Diseases, Institute of Medical Science, University of Tokyo, Japan
    J Clin Microbiol 38:3161-4. 2000
    ..1%]; P = 0.002). Our results thus suggest that DHPS mutations may contribute to failures of co-trimoxazole treatment for PCP...
  53. ncbi Genotypes of clustered cases of Pneumocystis carinii pneumonia
    M Olsson
    Swedish Institute for Infectious Disease Control and Microbiology and Tumor Biology Center, Karolinska Institutet, Stockholm, Sweden
    Scand J Infect Dis 33:285-9. 2001
    ..Although limited data on patient contacts were available, the detected P. c. hominis genotypes do not support person-to-person transmission as the predominant transmission route of P. carinii in humans...
  54. ncbi Effect of mutations in Pneumocystis carinii dihydropteroate synthase gene on outcome of P carinii pneumonia in patients with HIV-1: a prospective study
    T R Navin
    Division of Parasitic Diseases, National Center for Infectious, Diseases, Centers for Disease Control and Prevention, United States Public Health Service, Department of Health and Human Services, Atlanta, GA, USA
    Lancet 358:545-9. 2001
    ..Our results suggest that presence of a DHPS mutation should be only one of several criteria guiding the choice of initial drug treatment of P carinii pneumonia in patients with HIV-1 infection...
  55. pmc Decreased inflammatory response in Toll-like receptor 2 knockout mice is associated with exacerbated Pneumocystis pneumonia
    Shao Hung Wang
    Department of Medical Research, E Da Hospital, I Shou University, Kaohsiung 824, Taiwan, ROC
    Microbes Infect 10:334-41. 2008
    b>Pneumocystis pneumonia (PcP) is marked by substantial inflammatory damage to the lung...
  56. ncbi Comparison of clinical and radiological features of pneumocystis pneumonia between malignancy cases and acquired immunodeficiency syndrome cases: a multicenter study
    Sadatomo Tasaka
    Division of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, Tokyo
    Intern Med 49:273-81. 2010
    The clinical features of pneumocystis pneumonia (PCP) differ according to the predisposing factors responsible for immunosuppression...
  57. ncbi Pneumocystis carinii cytochrome b mutations are associated with atovaquone exposure in patients with AIDS
    P Kazanjian
    Department of Internal Medicine, University of Michigan Health System, 1500 E Medical Center Dr, Rm 3120B TC, Ann Arbor, MI 48109 0378, USA
    J Infect Dis 183:819-22. 2001
    ..14). Thus, cytochrome b mutations are significantly more common in patients with AIDS and PCP with atovaquone exposure, but the clinical significance of these mutations remains unknown...
  58. ncbi Prophylaxis failure is associated with a specific Pneumocystis carinii genotype
    P M Hauser
    Division Autonome de Médecine Préventive Hospitalière, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
    Clin Infect Dis 33:1080-2. 2001
    ..carinii genotype and receiving anti-PCP prophylaxis (odds ratio, 4.4; 95% confidence interval, 1.0-18.6; P=.05), although no association with a specific drug was detected...
  59. pmc Identification of Pneumocystis carinii f. sp. hominis gene sequences in filtered air in hospital environments
    M Olsson
    Swedish Institute for Infectious Disease Control and Microbiology and Tumor Biology Center, Karolinska Institutet, Stockholm
    J Clin Microbiol 36:1737-40. 1998
    ..carinii hominis from the environment...
  60. ncbi Prevalence of dihydropteroate synthase genotypes before and after the introduction of combined antiretroviral therapy and their influence on the outcome of Pneumocystis pneumonia in HIV-1-infected patients
    Miriam J Alvarez-Martinez
    Hospital Clínic IDIBAPS Institut d Investigació August Pi i Sunyer, Universitat de Barcelona, Barcelona, Spain
    Diagn Microbiol Infect Dis 68:60-5. 2010
    ..cART) and whether the mutations are associated with poor outcome in Spanish HIV-1-infected patients with Pneumocystis pneumonia (PcP)...
  61. ncbi Clearance of Pneumocystis carinii cysts in acute P carinii pneumonia: assessment by serial sputum induction
    W J O'Donnell
    Pulmonary Critical Care Division, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    Chest 114:1264-8. 1998
    ..To determine the feasibility of repeat sputum induction in acute Pneumocystis carinii pneumonia (PCP) and to define the rate of clearance of P carinii cysts from the respiratory tract of HIV-seropositive patients with acute PCP...
  62. pmc Pneumocystis: a novel pathogen in chronic obstructive pulmonary disease?
    Alison Morris
    Division of Pulmonary, Allergy, and Critical Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA
    COPD 5:43-51. 2008
    ..Additional studies are needed to confirm the role of Pneumocystis in the pathogenesis of COPD, given that this agent might be a treatable co-factor in disease progression...
  63. pmc Neither neutrophils nor reactive oxygen species contribute to tissue damage during Pneumocystis pneumonia in mice
    Steve D Swain
    Department of Veterinary Molecular Biology, Montana State University, Bozeman, Montana 59717, USA
    Infect Immun 72:5722-32. 2004
    ..We also show that there is no difference in Pneumocystis burdens between wild-type and knockout mice, which supports the idea that neutrophils do not have a major role in the clearance of this organism...
  64. pmc Lymphocyte apoptosis in murine Pneumocystis pneumonia
    Xin Shi
    Section of Pulmonary Critical Care Medicine, LSU Health Sciences Center, New Orleans, LA 70112, USA
    Respir Res 10:57. 2009
    ..We sought to characterize lymphocyte apoptosis in an animal model of pneumonia due to Pneumocystis murina, an infection localized to the lungs...
  65. ncbi Molecular diagnosis of Pneumocystis pneumonia
    Isabelle Durand-Joly
    Parasitology Mycology EA 3609, Lille 2 University Hospital Centre, France
    FEMS Immunol Med Microbiol 45:405-10. 2005
    ..of Pneumocystis DNA in clinical specimens by using PCR assays is leading to important advances in Pneumocystis pneumonia (PcP) clinical diagnosis, therapy and epidemiology...
  66. ncbi Effect of nicotine on lung S-adenosylmethionine and development of Pneumocystis pneumonia
    Mehboob Shivji
    Department of Medical and Molecular Parasitology, New York University School of Medicine, New York, New York 10010, USA
    J Biol Chem 280:15219-28. 2005
    ..and humans, nicotine reduces AdoMet of guinea pig lungs, and smoking correlates with reduced episodes of Pneumocystis pneumonia (PCP) in AIDS patients, we tested the effect of nicotine treatment on PCP using a rat model...
  67. ncbi Advances in the biology, pathogenesis and identification of Pneumocystis pneumonia
    Bryan J Krajicek
    Thoracic Diseases Research Unit, Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA
    Curr Opin Pulm Med 14:228-34. 2008
    b>Pneumocystis pneumonia remains the most prevalent opportunistic infection in patients with AIDS. It is also a common devastating infection in patients with other causes of altered immunity...
  68. ncbi Epidemiology of human immunodeficiency virus-associated opportunistic infections in the United States in the era of highly active antiretroviral therapy
    J E Kaplan
    Division of HIV AIDS Prevention Surveillance and Epidemiology, National Center for HIV, STD and TB Prevention, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Clin Infect Dis 30:S5-14. 2000
    ..Continued monitoring of incidence trends and detection of new syndromes associated with HAART are important priorities in the HAART era...
  69. pmc Immune-mediated inflammation directly impairs pulmonary function, contributing to the pathogenesis of Pneumocystis carinii pneumonia
    T W Wright
    Department of Pediatrics, Department of Microbiology University of Rochester School of Medicine, Rochester, New York 14642, USA
    J Clin Invest 104:1307-17. 1999
    ..carinii directly impairs pulmonary function and contributes to the pathogenesis of PCP. Furthermore, CD8(+) T cells likely contribute to the respiratory compromise observed during PCP...
  70. ncbi Pneumocystis colonisation is common among hospitalised HIV infected patients with non-Pneumocystis pneumonia
    J L Davis
    Division of Pulmonary and Critical Care Medicine, San Francisco General Hospital, University of California, San Francisco, San Francisco, California, USA
    Thorax 63:329-34. 2008
    When Pneumocystis DNA is recovered from respiratory specimens of patients without Pneumocystis pneumonia (PCP), patients are said to be colonised with Pneumocystis, although the significance of this state is unknown...
  71. pmc Molecular evidence of interhuman transmission of Pneumocystis pneumonia among renal transplant recipients hospitalized with HIV-infected patients
    Meja Rabodonirina
    Hopital de la Croix Rousse, Lyon, France
    Emerg Infect Dis 10:1766-73. 2004
    ..jirovecii molecular type as that found in the encountered PCP patients. The data suggest that part of the PCP cases observed in this building, particularly those observed in RTRs, were related to nosocomial interhuman transmission...
  72. ncbi Pneumocystis jiroveci pneumonia and other pulmonary infections in TB smear-negative HIV-positive patients with atypical chest X-ray in Ethiopia
    Getachew Aderaye
    Departments of Internal Medicine, Addis Ababa University, Addis Ababa, Ethiopia
    Scand J Infect Dis 39:1045-53. 2007
    b>Pneumocystis pneumonia (PCP) has been considered a rare disease in sub-Saharan Africa. However, a rising prevalence has been noted recently...
  73. ncbi Pneumocystis carinii pneumonia in patients being registered for smear-negative pulmonary tuberculosis in Malawi
    N J Hargreaves
    National Tuberculosis Control Programme, Community Health Sciences Unit, Private Bag 65, Lilongwe Central Hospital, Box 149, Lilongwe, Malawi
    Trans R Soc Trop Med Hyg 95:402-8. 2001
    ..The outcome of PCP cases was poor despite management with high-dose co-trimoxazole and secondary co-trimoxazole prophylaxis, with a median survival of 4 months (25-75% range: 2-12 months)...
  74. pmc Early predictors of mortality from Pneumocystis jirovecii pneumonia in HIV-infected patients: 1985-2006
    Peter D Walzer
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, University College London, London, United Kingdom
    Clin Infect Dis 46:625-33. 2008
    ..Previous studies of PCP that identified case-fatality risk factors involved small numbers of patients, were performed over few years, and often focused on patients who were admitted to the intensive care unit...
  75. ncbi Sulfa or sulfone prophylaxis and geographic region predict mutations in the Pneumocystis carinii dihydropteroate synthase gene
    L Huang
    Positive Health Program, Ward 84, San Francisco General Hospital, San Francisco, CA 94110, USA
    J Infect Dis 182:1192-8. 2000
    ....
  76. ncbi Pneumocystis pneumonia: current concepts in pathogenesis, diagnosis, and treatment
    Bryan J Krajicek
    Division of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, MN 55905, USA
    Clin Chest Med 30:265-78, vi. 2009
    b>Pneumocystis pneumonia (PCP) is an infection of the lungs caused by the opportunistic fungal genus Pneumocystis...
  77. pmc Improved survival for HIV infected patients with severe Pneumocystis jirovecii pneumonia is independent of highly active antiretroviral therapy
    R F Miller
    Centre for Sexual Health and HIV Research, University College London, Mortimer Market Centre, London WC1E 6AU, UK
    Thorax 61:716-21. 2006
    ..A study was undertaken to examine the outcome from intensive care for patients with PCP and to identify prognostic factors...
  78. ncbi Low sensitivity of a nested polymerase chain reaction in oropharyngeal washings for the diagnosis of pneumocystis pneumonia in HIV-infected patients
    Kennedy Nyamande
    FRCP London, University of KwaZulu Natal, Nelson R Mandela School of Medicine, Department of Medicine, Pulmonology Unit, Private Bag X7, Congella, Durban 4013, South Africa
    Chest 128:167-71. 2005
    ..To compare the relative yield and diagnostic utility of the polymerase chain reaction (PCR) analysis for Pneumocystis jirovecii DNA in oropharyngeal washings using transbronchial biopsy (TBBx) and BAL as "gold standards."..
  79. ncbi Occurrence of Pneumocystis carinii in HIV-positive patients with suspected pulmonary tuberculosis in Ethiopia
    Getachew Aderaye
    Department of Internal Medicine, Black Lion University Hospital, Addis Ababa, Ethiopia
    AIDS 17:435-40. 2003
    ..To investigate the prevalence of Pneumocystis carinii in consecutive HIV-positive patients with suspected pulmonary tuberculosis (PTB) attending a university hospital in Ethiopia...
  80. pmc Pneumocystis jiroveci internal transcribed spacer types in patients colonized by the fungus and in patients with pneumocystosis from the same French geographic region
    Gilles Nevez
    Department of Parasitology, Mycology and Travel Medicine, University Hospital of Amiens, Jules Verne University of Picardy, 80054 Amiens, France
    J Clin Microbiol 41:181-6. 2003
    ..jiroveci ITS genotypes in colonized patients and patients with PCP suggest that human populations infected by P. jiroveci, whatever the clinical manifestation, may play a role as a common reservoir for the fungus...
  81. ncbi Reasons for lack of appropriate receipt of primary Pneumocystis jiroveci pneumonia prophylaxis among HIV-infected persons receiving treatment in the United States: 1994-2003
    Eyasu H Teshale
    Division of HIV AIDS Prevention, National Center for HIV, Sexually Transmitted Disease, and Tuberculosis Prevention, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Clin Infect Dis 44:879-83. 2007
  82. ncbi Survival pathway signal transduction is reduced in alveolar macrophages during Pneumocystis pneumonia
    Mark E Lasbury
    Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    J Eukaryot Microbiol 53:S130-1. 2006
  83. ncbi Pneumocystis carinii pneumonia in HIV-infected patients in the HAART era
    Joseph Pulvirenti
    Division of Infectious Diseases, Cook County Hospital, Rush Medical College, Chicago, Illinois 60612, USA
    AIDS Patient Care STDS 17:261-5. 2003
    ..An aggressive approach toward HIV identification and substance abuse treatment may decrease admissions to the hospital for PCP and improve response to HAART therapy...
  84. ncbi Resolution of Pneumocystis murina infection following withdrawal of corticosteroid induced immunosuppression
    Michael Linke
    Department of Veterans Affairs Medical Center, Research Service, Cincinnati, OH 45220, USA
    Microb Pathog 40:15-22. 2006
    ..Withdrawal of Dex induced immunosuppression from P. murina infected mice resulted in activation of many arms of the host response that lead to resolution of the infection...
  85. ncbi Caspofungin treatment of Pneumocystis pneumonia during conditioning for bone marrow transplantation
    C Annaloro
    Ematologia I e Centro Trapianti di Midollo, Fondazione Ospedale Maggiore and Università degli Studi di Milano, Via Francesco Sforza 35, 20122 Milan, Italy
    Eur J Clin Microbiol Infect Dis 25:52-4. 2006
  86. pmc Autoimmune inflammatory disorders, systemic corticosteroids and pneumocystis pneumonia: a strategy for prevention
    Evin Sowden
    Department of Dermatology, The James Cook University Hospital, Marton Road, Middlesbrough TS4 3BW UK
    BMC Infect Dis 4:42. 2004
    b>Pneumocystis pneumonia (PCP) is an increasing problem amongst patients on immunosuppression with autoimmune inflammatory disorders (AID). The disease presents acutely and its diagnosis requires bronchoalveolar lavage in most cases...
  87. ncbi Guidelines for preventing opportunistic infections among HIV-infected persons--2002. Recommendations of the U.S. Public Health Service and the Infectious Diseases Society of America
    Jonathan E Kaplan
    Division of AIDS, STD, and TB Laboratory Research, National Center for Infectious Diseases, USA
    MMWR Recomm Rep 51:1-52. 2002
    ....
  88. ncbi S-adenosylmethionine concentrations in diagnosis of Pneumocystis carinii pneumonia
    Michael Skelly
    Department of Medicine, New York University Bellevue Hospital Center, New York, NY, USA
    Lancet 361:1267-8. 2003
    ..Measurement of plasma S-adenosylmethionine concentrations could prove useful for diagnosis of PCP and assessment of patients' response to treatment...
  89. ncbi Emergence of trimethoprim-sulfamethoxazole resistance in the AIDS era
    J N Martin
    Center for AIDS Prevention Studies and Department of Epidemiology and Biostatistics, University of California, San Francisco, USA
    J Infect Dis 180:1809-18. 1999
    ..A rapid increase in the use of prophylactic TMP-SMX in HIV disease was also observed during this time in San Francisco and is likely responsible for the increase in TMP-SMX resistance...
  90. ncbi Pneumocystis pneumonia associated with infliximab in Japan
    Masayoshi Harigai
    N Engl J Med 357:1874-6. 2007
  91. ncbi Risk for preventable opportunistic infections in persons with AIDS after antiretroviral therapy increases CD4+ T lymphocyte counts above prophylaxis thresholds
    M S Dworkin
    Division of HIV AIDS Prevention, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    J Infect Dis 182:611-5. 2000
    ..0 cases per 100 PY) and not higher than in persons whose CD4(+) counts had not decreased below these thresholds, which suggests that discontinuation of primary prophylaxis for opportunistic infections may be considered for some patients...
  92. ncbi Acute respiratory failure due to pneumocystis pneumonia in patients without human immunodeficiency virus infection: outcome and associated features
    Emir Festic
    Division of Primary and Critical Care Medicine, Department of Internal Medicine, Mayo Clinic, Rochester, MN, USA
    Chest 128:573-9. 2005
    To examine outcome and associated factors of acute respiratory failure (ARF) in non-HIV-related Pneumocystis pneumonia (PCP) in patients admitted to a medical ICU between 1995 and 2002.
  93. ncbi Current insights into the biology and pathogenesis of Pneumocystis pneumonia
    Charles F Thomas
    Thoracic Diseases Research Unit, Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Rochester, Minnesota 55905, USA
    Nat Rev Microbiol 5:298-308. 2007
    The fungal infection Pneumocystis pneumonia is the most prevalent opportunistic infection in patients with AIDS...
  94. ncbi Prophylaxis of Pneumocystis pneumonia in immunocompromised non-HIV-infected patients: systematic review and meta-analysis of randomized controlled trials
    Hefziba Green
    Unit of Infectious Diseases, Rabin Medical Centre, Beilison Hospital, Petah Tikva 49100, Israel
    Mayo Clin Proc 82:1052-9. 2007
    To assess the efficacy of prophylaxis for Pneumocystis pneumonia (PCP), caused by Pneumocystis jirovecii (formerly Pneumocystis carinii), for immunocompromised non-HIV-infected patients by conducting a systematic review and meta-analysis.
  95. ncbi Lung diseases at necropsy in African children dying from respiratory illnesses: a descriptive necropsy study
    Chifumbe Chintu
    University of Zambia University College London Medical School Research and Training Project, University Teaching Hospital, Lusaka, Zambia
    Lancet 360:985-90. 2002
    ..We undertook a study of children who died from respiratory diseases at University Teaching Hospital, Lusaka, Zambia...
  96. ncbi Lymphocyte surge as a marker for immunorestitution disease due to Pneumocystis jiroveci pneumonia in HIV-negative immunosuppressed hosts
    V C C Cheng
    Division of Infectious Diseases, Centre of Infection, Queen Mary Hospital, The University of Hong Kong, Hong Kong Special Administrative Region, Hong Kong, China
    Eur J Clin Microbiol Infect Dis 23:512-4. 2004
  97. ncbi Pneumocystis pneumonia
    Charles F Thomas
    Thoracic Diseases Research Unit, Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Mayo Clinic College of Medicine, Rochester, Minn, USA
    N Engl J Med 350:2487-98. 2004
  98. ncbi Immunocompetent hosts as a reservoir of pneumocystis organisms: histological and rt-PCR data demonstrate active replication
    M Chabé
    Ecology of Parasitism, Lille Pasteur Institute, 1 rue du Prof Calmette BP245, 59019, Lille, France
    Eur J Clin Microbiol Infect Dis 23:89-97. 2004
    ..The results showed Pneumocystis organisms were able to replicate in the lungs of immunocompetent hosts, which indicates these hosts are a reservoir for Pneumocystis spp...
  99. ncbi Pneumocystis jiroveci pneumonia in a patient with Wegener's granulomatosis treated efficiently with caspofungin
    Herbert Hof
    Institute for Microbiology and Hygiene, University Hospital Mannheim, Medical Faculty Mannheim of the University of Heidelberg, Germany
    Mycoses 51:65-7. 2008
    ..The patient's complaints subsequently resolved within days after initiation of treatment. Tolerability of the drug was excellent. No relapse occurred during the ongoing 4 years, although immunosuppressive therapy continued...
  100. pmc Parenchymal cell TNF receptors contribute to inflammatory cell recruitment and respiratory failure in Pneumocystis carinii-induced pneumonia
    Gloria S Pryhuber
    Department of Pediatrics, University of Rochester Medical Center, Rochester, NY 14642, USA
    J Immunol 181:1409-19. 2008
    ..This study supports a key role of parenchymal cell TNFRs in lung injury induced by Pc and a potential protective effect of receptors on radiosensitive, bone marrow-derived cells...
  101. ncbi Pneumocystis carinii pneumonia in patients with hematologic malignancies: a descriptive study
    F Roblot
    Infectious Diseases Unit, Department of Internal Medicine, University Hospital, Poitiers, France
    J Infect 47:19-27. 2003
    ..Prognosis remains poor. The diagnosis should be advocated more frequently and earlier to improve the prognosis...

Research Grants65

  1. Modulation of host immune defense by Pneumocystis beta-glucans
    EVA MARIA CARMONA PORQUERA; Fiscal Year: 2013
    ..When Pneumocystis pneumonia (PcP) develops it carries great morbidity and mortality even upon administration of appropriate treatment...
  2. Identification of new compounds against fungal microbes
    Maurizio Del Poeta; Fiscal Year: 2013
    ..The synthesis of GlcCer seems to be important also during Pneumocystis pneumonia (PCP) as glucosylceramide synthase transcripts have been found to be abundant at the time of isolation of ..
  3. Immune response to Pneumocystis and bone marrow failure
    Nicole Meissner; Fiscal Year: 2013
    ..provided by applicant): In AIDS patients'susceptibility to opportunistic infections, such as Pneumocystis Pneumonia (PCP), occurs due to the loss of CD4 T cells and type I interferon (type-I-IFN) producing plasmacytoid ..
  4. Pneumocystis carinii: Macrophage &Epithelial Activation
    Andrew H Limper; Fiscal Year: 2013
    ..Lung inflammation during Pneumocystis pneumonia (PcP) strongly contributes to lung injury and death...
  5. Patient-Oriented Research and Mentoring in Pneumocystis
    Laurence Huang; Fiscal Year: 2010
    ..The initial studies in Kampala will investigate the non-invasive diagnosis of Pneumocystis pneumonia (PCP) and TB and will examine trimethoprim-sulfamethoxazole drug resistance in Pneumocystis...
  6. Eosinophils and lung immunity to Pneumocystis
    Chad Steele; Fiscal Year: 2013
    ..by applicant): Despite the advent of prophylaxis and HAART therapy, the mortality rate associated with Pneumocystis pneumonia in HIV/AIDS remains similar to that reported prior to the initiation of these therapies...
  7. Role of B cells in host defense against Pneumocystis
    Beth A Garvy; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Pneumocystis pneumonia is an AIDS-defining illness that has continued to cause significant morbidity and mortality among HIV-infected patients with compromised CD4 T cells...
  8. STAT4 mediated immunity to Pneumocystis
    Chad Steele; Fiscal Year: 2012
    ..Loss of CD4+ T cells is a known predisposing factor to Pneumocystis pneumonia, yet how CD4+ T cells specifically control Pneumocystis infection is not known...
  9. T cells and P carinii Pneumonia
    Jay K Kolls; Fiscal Year: 2013
    ..PUBLIC HEALTH RELEVANCE: This project defines the types of T-cells required for prevention of Pneumocystis pneumonia a major complication of AIDS and organ transplantation...
  10. Host response to P. carinii in neonatal mice
    Beth A Garvy; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Pneumocystis pneumonia PCP) causes significant morbidity and mortality among HIV-infected individuals who are newly diagnosed, failed retroviral therapy, or do not have access to care...
  11. P. carinii Pneumonia Lung Damage: CD8-driven Cellular and Molecular Events
    Terry W Wright; Fiscal Year: 2012
    ..The experiments outlined in this proposal are designed to lead to a translational clinical trial designed to improve the management of patients with P. carinii pneumonia. ..
  12. CD4 T cell-mediated lung damage in Pneumocystis pneumonia
    Allen G Harmsen; Fiscal Year: 2013
    ....
  13. Macrophage effector functions during respiratory fungal infection
    Terry W Wright; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Despite general advances in patient care, Pneumocystis pneumonia (PcP)-related mortality remains unacceptably high...
  14. MULTICITY STUDY OF QUALITY OF CARE FOR HIV-RELATED TB
    Charles Bennett; Fiscal Year: 2000
    ....
  15. A role of osteopontin in innate immunity against fungal infection
    Mari L Shinohara; Fiscal Year: 2013
    ..OPN) plays a critical role in defense against an opportunistic fungus, Pneumocystis, which causes Pneumocystis pneumonia (PCP)...
  16. S-Adenosylmethionine and Pneumocystis treatment
    Salim Merali; Fiscal Year: 2010
    b>Pneumocystis pneumonia (PCP) is a fungal disease associated with immunosuppressive conditions such as AIDS, cancer, rheumatic disease, organ transplant, malnutrition, etc...
  17. DICATIONIC DRUGS--TREATMENT FOR AIDS-RELATED INFECTIONS
    Richard Tidwell; Fiscal Year: 1999
    ..Such an integrated approach will maximize the chances of achieving our final goal, the development of new agents for the treatment of AIDS- Associated opportunistic infections. ..
  18. Aveolar Macrophage Apoptosis and Pneumocystis
    Chao Hung Lee; Fiscal Year: 2009
    ..The number of alveolar macrophages is decreased in humans with Pneumocystis pneumonia (Pep)...
  19. Novel, P. jirovecii Specific Antipneumocystis Agents
    Aleem Gangjee; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Pneumocystis pneumonia (PCP) is the most common and life threatening opportunistic infection in AIDS patients and is responsible for extensive morbidity and mortality...
  20. PRIMAQUINE-INDUCED HEMOLYTIC ANEMIA
    DAVID MC MILLAN; Fiscal Year: 2004
    ....
  21. co-Trimoxazole in Zambian Infants (TZI)
    CHRISTOPHER GILL; Fiscal Year: 2007
    ..that infants exposed to HIV at birth should receive cotrimoxazole (TMZ-SMZ) as empiric prophylaxis against Pneumocystis pneumonia for one year without confirmation of H1V infection...
  22. MECHANISMS OF PNEUMOCYSTIS CARINII PNEUMONIA
    William Martin; Fiscal Year: 1999
    ....
  23. ANTI-INFLAMMATORY ACTIVITY OF DAPSONE
    PAULA BOZEMAN; Fiscal Year: 1993
    ..These studies will increase understanding of the peroxidase/Cl-/H2O2 system, will elucidate the mechanism of dapsone's anti-inflammatory actions, and may suggest treatment modalities to block inflammatory tissue destruction...
  24. Structural Studies of AIDS-Responsive Drugs
    Vivian Cody; Fiscal Year: 2010
    ..Pneumocystis jirovecii (pj) is the causative agent of Pneumocystis pneumonia(PcP), one of the most frequent and severe opportunistic infections in immunocompromised patients...
  25. HIV-related oral diseases among women in Harare
    John Greenspan; Fiscal Year: 2004
    ..in this setting with respect to initiation of certain prophylactic drug regimens (such as tuberculosis or pneumocystis pneumonia prophylaxis) or anti-retrovirals...
  26. S-Adenosylmethionine and Pneumocystis treatment
    Salim Merali; Fiscal Year: 2009
    ..The fungus Pneumocystis, an important lung pathogen for immunosuppressed persons which causes Pneumocystis pneumonia (PCP), requires AdoMet, as do all other cells...
  27. PNEUMOCYSTIS CARINII PNEUMONIA MODEL IN RHESUS MACAQUES
    Karen Norris; Fiscal Year: 2002
    ..carinii and determine the relevance of the nonhuman primate model, thus providing the means to study many aspects of PCP previously unapproachable due to the limitations of other animal models. ..
  28. PATHOGENESIS OF PNEUMOCYSTIS CARINII PNEUMONIA
    MIERCIO PEREIRA; Fiscal Year: 1999
    ..carinii attachment to lung epithelium; 7) Determine trans- sialidase pathway in P. carinii adherence; 8) Test effectiveness of humoral response to the trans- sialidase against P. carinii infection. ..
  29. NOVEL ANTI-PCP AGENTS WITH NEUROPROTECTIVE PROPERTIES
    TIEN HUANG; Fiscal Year: 2001
    ....
  30. GENETIC APPROACH TO UNDERSTANDING PNEUMOCYSTIS THERAPY
    Chuck Staben; Fiscal Year: 1993
    ..carinii infections in AIDS patients by providing a basis for improving therapeutics used to treat Pneumocystis pneumonia. Pneumocystis pneumonia is a common opportunistic infection and leading cause of death of AIDS patients...
  31. Models of P. carinii Infection: SP-A and SP-D null mice
    Michael Beers; Fiscal Year: 2009
    ....
  32. YEAST MODELS OF DRUG-RESISTANT PNEUMOCYSTIS CARINII
    Steven Meshnick; Fiscal Year: 2004
    ..Ultimately, it is hoped that the results of this study will facilitate the rational use of antipneumocystis drugs. ..
  33. SURFACTANT METABOLISM IN PNEUMOCYSTIS CARINII PNEUMONIA
    Michael Beers; Fiscal Year: 2002
    ..A co-investigator experienced with P. carinii biology and gpA purification; 3. Consultants recognized as authorities on the scid mouse model of PCP and on isolated lung perfusion. ..
  34. HEALTH STATUS MEASURE OF DRUG THERAPY FOR PCP
    Albert Wu; Fiscal Year: 1993
    ..In addition, the study will provide insights about the added value provided by health status measures, and about whether a translated measure is equivalent enough to allow data to be aggregated across linguistically diverse populations...
  35. DRUGS FOR TREATMENT OF PNEUMOCYSTIS CARINII
    James Smith; Fiscal Year: 1993
    In the past two years pneumocystis pneumonia has become the major opportunistic disease in patients with acquired immunodeficiency syndrome (AIDS)...
  36. ENVIRONMENTAL AND MOLECULAR EPIDEMIOLOGY OF P CARINII
    Sten Vermund; Fiscal Year: 2001
    ..The long-term objective of this research is to prevent the transmission of PC in the health care as well as the home setting, thereby reducing the risk of PC infection among immunosuppressed individuals. ..
  37. MEDICAL AND SUBSTANCE ABUSE CARE FOR HIV+ DRUG USERS
    Barbara Turner; Fiscal Year: 2000
    ..Health planners and providers require these data to foster and develop efficient systems for care for drug users in a changing health care environment. ..
  38. NEW METHODS FOR DETERMINATION OF PENTAMIDINE
    Thomas Bell; Fiscal Year: 1991
    ..Variable functional groups will then be used to achieve the correct physical properties, enabling the synthetic receptor to bind pentamidine strongly, selectively and with a fluorescent response...
  39. EVALUATION OF PNEUMOCYSTIS CARINII PNEUMONIA
    ALAN SMULIAN; Fiscal Year: 1990
    ..The quantitation and characterization of organism antigens, detailed morphological and viability studies, and assay of host serological responses may be helpful in assessing prognosis and monitoring therapy...
  40. Functional Annotations for the Pneumocystis Genome.
    Jarek Meller; Fiscal Year: 2004
    ..Pc causes one of the major HIV-associated infections, Pneumocystis pneumonia (PcP)...
  41. Immune response to Pneumocystis in simian model of AIDS
    Karen Norris; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Pneumocystis pneumonia (PCP) remains an important cause of morbidity and mortality in HIV-infected patients...
  42. PNEUMOCYSTIS INFECTION IN AIDS: BIOLOGY AND PATHOGENESIS
    Gregory Buck; Fiscal Year: 1990
    ..carinii DNA as probe. Finally, the highly repeated sequences and the rDNA clones will be assessed for specifically and sensitivity as potential diagnostic tools...
  43. VARIATIONS BETWEEN RURAL AND URBAN AIDS CARE
    Susan Cohn; Fiscal Year: 1992
    ..Sheps Center for Health Services Research to develop and apply methods for evaluating the importance of geographic factors in understanding variations in care for AIDS patients...
  44. DO GLUCOCORTICOIDS EXACERBATE GP120 NEUROENDANGERMENT
    Robert Sapolsky; Fiscal Year: 2002
    ..That, coupled with the possible implications of the stressfulness of HIV infection prompt the proposed studies. ..
  45. QUALITY OF CARE IN AIDS: P. CARINII PNEUMONIA
    David Kanouse; Fiscal Year: 1990
    ..This project will contribute to clinical research and patient care by identifying which features of care make the greatest difference in patient outcomes, for the most common presenting manifestation of AIDS...
  46. DEVELOPMENT OF NOVEL ANTIFUNGAL ANTIPC NATURAL PRODUCTS
    Mitchell Avery; Fiscal Year: 2001
    ....
  47. FRACTIONAL UPTAKE (CO) AS AN INDICATOR OF PCP PNEUMONIA
    BRIAN CRAINE; Fiscal Year: 1992
    ..During the Phase I of this study, the investigators will demonstrate that FU(CO) measurements are reproducible and determine the magnitude of the effect of physiological parameters (such as tidal volume) on the FU(CO) measurement...
  48. VARIATIONS IN CARE OF AIDS PATIENTS WITH 1ST EPISODE PCP
    Charles Bennett; Fiscal Year: 1993
    ..It will be the first large-scale analysis of variations in care for AIDS patients that addresses differences in risk group, type of hospital, city, and severity of illness...
  49. MECHANISMS OF CD8+ T CELL DEFENSE AGAINST PNEUMOCYSTIS
    James Beck; Fiscal Year: 2000
    ....
  50. CD8 T CELL DEPENDENT DAMAGE IN PNEUMOCYSTIS PNEUMONIA
    Allen Harmsen; Fiscal Year: 2001
    ..They will investigate both the roles of T-cell derived perforin and recruited neutrophils in mediating this CD8 dependent lung injury. ..
  51. Lung Damage from P. carinii: pathogenesis and prevention
    Francis Gigliotti; Fiscal Year: 2006
    ..This investigative effort will identify potential sites for therapeutic intervention to reduce the morbidity and mortality associated with PcP. I ..
  52. PNEUMOCYSITIS CARINII INFECTION THERAPIES--PRECLIN EVAL
    Peter Walzer; Fiscal Year: 2000
    ..Therapeutic agents will be evaluated for activity in a standardized, reproducible and validated in vitro (culture) test system which employs intact organisms. ..
  53. NINTH INTERNATIONAL WORKSHOPS ON OPPORTUNISTIC PEOTISTS (IWOP-9)
    EDNA KANESHIRO; Fiscal Year: 2006
    ..As in several IWOP meetings in the past, the 2006 Workshops will be held jointly with the annual meetings of the International Society of Protistologists ( formerly Society of Protozoologists). ..
  54. Sterol Metabolism in Pneumocystis
    EDNA KANESHIRO; Fiscal Year: 2009
    ..Because Pneumocystis pneumonia remains a major opportunistic infection in AIDS patients worldwide, and because various drug resistant ..
  55. Pneumocystis Biochemistry: Ubiquinones
    EDNA KANESHIRO; Fiscal Year: 2002
    ..carinii CoQ biosynthesis and growth in axenic cultures, and (4) develop atovaquone-resistant P. carinii populations to evaluate CoQ synthesis in sensitive and resistant organisms. ..
  56. Molecular Epidemiology of Human P. carinii Pneumonia
    Laurence Huang; Fiscal Year: 2006
    ..abstract_text> ..
  57. PNEUMOCYSTIS GENOME PROJECT
    Melanie Cushion; Fiscal Year: 2004
    ..Thus, there is but a single aim to this proposal: 1. To finish sequencing the genome of pneumocystis carinii and provide a completed assembly. ..
  58. New Approaches for Development of PcP Therapy
    Melanie Cushion; Fiscal Year: 2006
    ..Finally, they will select the most efficacious combinations of agents and evaluate their effects on gene expression again using the macroarray approach. ..
  59. P CARINII PNEUMONIA--IMMUNOPATHOGENESIS OF LUNG INJURY
    Francis Gigliotti; Fiscal Year: 2001
    ..If this hypothesis is proven correct, the information gained from the proposed studies can be utilized to develop new therapeutic modalities to improve the morbidity and mortality resulting from PCP. ..
  60. Pathogenesis of HIV-Related Emphysema: T Cells, smoking*
    James Beck; Fiscal Year: 2009
    ..b>Pneumocystis pneumonia remains an important cause of morbidity and mortality in HIV-infected individuals...
  61. CYTOKINE CONTROL OF HOST SUSCEPTIBILITY TO PNEUMOCYSTIS
    James Beck; Fiscal Year: 2001
    ..Carini using in vivo approaches that model human P. Carinii pneumonia. Ultimately, these studies can be extended to develop therapeutic strategies directed against this important opportunistic pathogen. ..
  62. TRANSMISSION OF PNEUMOCYSTIS INFECTION
    Melanie Cushion; Fiscal Year: 2001
    ..These studies will result in a clearer understanding of the biology leading to infection with Pc and will provide a rational basis for clinical management and therapeutic intervention. ..
  63. MONOCLONAL ANTIBODIES FOR THE STUDY OF P. CARINII
    Francis Gigliotti; Fiscal Year: 2009
    ..We will also determine the microbiologic effect of combining passive antibody therapy with conventional antimicrobial therapy. ..