- Pulmonary fungal infection: emphasis on microbiological spectra, patient outcome, and prognostic factors
K Y Chen
Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan
Chest 120:177-84. 2001
..Early diagnosis with prompt antifungal therapy, or even with surgical intervention, might be warranted to save patients' lives...
- Dynamic changes in the morphology of Cryptococcus neoformans during murine pulmonary infection
Department of Medicine, Division of Infectious Diseases, Albert Einstein College of Medicine, Bronx, NY 10461, USA
Microbiology 147:2355-65. 2001
..The results indicate that the population of C. neoformans cells in tissue is in a highly dynamic state, implying that the immune system must confront cells with varying characteristics during the course of infection...
- Increasing volume and changing characteristics of invasive pulmonary aspergillosis on sequential thoracic computed tomography scans in patients with neutropenia
Department of Clinical Hematology, University Hospital of Dijon, Dijon, France
J Clin Oncol 19:253-9. 2001
..In patients with neutropenia, thoracic computed tomography (CT) halo and air-crescent signs are recognized as major indicators of invasive pulmonary aspergillosis (IPA). Nevertheless, the exact timing of CT images is not well known...
- Combination therapy in treatment of experimental pulmonary aspergillosis: synergistic interaction between an antifungal triazole and an echinocandin
Immunocompromised Host Section, Pediatric Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
J Infect Dis 187:1834-43. 2003
..The combination of an antifungal triazole and echinocandin may represent a new strategy for treatment of invasive pulmonary aspergillosis...
- Management of invasive pulmonary aspergillosis in non-neutropenic critically ill patients
R J Trof
Department of Intensive Care, VU Medical Centre, De Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands
Intensive Care Med 33:1694-703. 2007
..The benefit of combination antifungal therapy lacks sufficient evidence so far, but this treatment might be considered in patients with breakthrough infections or refractory disease...
- Distinct roles for IL-4 and IL-10 in regulating T2 immunity during allergic bronchopulmonary mycosis
Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor 48109, USA
J Immunol 174:1027-36. 2005
..Thus, although IL-10 has been reported to down-regulate pulmonary T2 responses to isolated fungal Ags, IL-10 can augment pulmonary T2 responses if they occur in the context of fungal infection...
- Detection of galactomannan antigenemia by enzyme immunoassay for the diagnosis of invasive aspergillosis: variables that affect performance
Kieren A Marr
Fred Hutchinson Cancer Research Center and University of Washington, Seattle, Washington 98109, USA
J Infect Dis 190:641-9. 2004
..The 0.5 cutoff may allow for better performance as an early diagnostic test...
- A systematic literature review on the diagnosis of invasive aspergillosis using polymerase chain reaction (PCR) from bronchoalveolar lavage clinical samples
Felipe Francisco Tuon
Department of Infectious Diseases, Hospital das Clinicas, Faculdade de Medicina da Universidade de Sao Paulo, Brazil
Rev Iberoam Micol 24:89-94. 2007
..The present study showed support for the clinical value of PCR from BAL for the diagnosis of invasive aspergillosis in patients with risk factors for this disease...
- Aspergillus galactomannan enzyme immunoassay and quantitative PCR for diagnosis of invasive aspergillosis with bronchoalveolar lavage fluid
University of Washington, Seattle, WA, USA
J Clin Microbiol 42:5517-22. 2004
..GM EIA and qPCR assay add to the sensitivity of BAL for diagnosing IPA in high-risk patients, with excellent specificity. Adjunctive use of these tests may reduce dependence on invasive diagnostic procedures...
- Pulmonary cryptococcosis in immunocompetent patients: CT findings in 12 patients
Danial L Fox
Department of Radiology, Vancouver General Hospital, Vancouver, BC V5Z 1M9, Canada
AJR Am J Roentgenol 185:622-6. 2005
..The aim of our study was to review the CT findings of pulmonary cryptococcosis in 12 immunocompetent patients...
Robert W Bradsher
University of Arkansas for Medical Sciences, Central Arkansas Veterans Administration, Little Rock, AR, USA
Infect Dis Clin North Am 17:21-40, vii. 2003
..Itraconazole has been shown to be the drug of choice for both infections, except in cases of life-threatening infection when amphotericin B should be used...
- Characteristics of integrated 18F-FDG PET/CT in Pulmonary Cryptococcosis
Chung Jen Huang
Division of Pulmonary and Intensive Care Medicine, Koo Foundation Sun Yat Sen Cancer Center, Taipei, Taiwan
Acta Radiol 50:374-8. 2009
..Pulmonary cryptococcosis is an uncommon cause of pulmonary nodules found by (18)F-fluorodeoxyglucose positron emission tomography/computed tomography ((18)F-FDG PET/CT) scans. It is rarely reported but may mislead interpretation...
- IL-13 induces disease-promoting type 2 cytokines, alternatively activated macrophages and allergic inflammation during pulmonary infection of mice with Cryptococcus neoformans
Institute of Immunology, College of Veterinary Medicine, University of Leipzig, Leipzig, Germany
J Immunol 179:5367-77. 2007
..This indicates that IL-13 contributes to fatal allergic inflammation during C. neoformans infection...
- Evaluation of the role of real-time PCR in the diagnosis of invasive aspergillosis
R B Ferns
Royal Free and University College Medical School, University College London, Division of Infection and Immunity, Department of Infection, Centre of Virology, London, UK
Leuk Lymphoma 47:15-20. 2006
..The effect of anti-fungal treatment is noted. The requirement for both international standards and a consensus protocol that is sensitive enough for IA diagnosis, particularly in blood, is discussed...
- Significance of Aspergillus fumigatus isolation from respiratory specimens of nongranulocytopenic patients
M L Uffredi
Service de Pneumologie, Hopital Tenon, 4 rue de la Chine, 75020 Paris, France
Eur J Clin Microbiol Infect Dis 22:457-62. 2003
- Invasive pulmonary and central nervous system aspergillosis after near-drowning of a child: case report and review of the literature
Division of Pediatric Intensive Care, Department of Pediatrics, University Hospital Maastricht, PO Box 5800, 6202 AZ Maastricht, Netherlands
Pediatrics 118:e509-13. 2006
..Currently voriconazole, eventually in combination with caspofungin, should be considered as the drug of choice in the management of invasive aspergillosis after near-drowning...
- Chronic obstructive pulmonary disease patients with invasive pulmonary aspergillosis: benefits of intensive care?
P A Bulpa
Department of Intensive Care, Mont Godinne University Hospital, Universite Catholique de Louvain, Yvoir, Belgium
Intensive Care Med 27:59-67. 2001
..For these patients admission in intensive care unit (ICU) is often required for life-support and mechanical ventilation. Whether this approach improves outcome is unknown...
- Neutropenia alters lung cytokine production in mice and reduces their susceptibility to pulmonary cryptococcosis
Aron J Mednick
Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY, USA
Eur J Immunol 33:1744-53. 2003
..Our results support the emerging concept that neutrophils play an important function in modulating the development of the immune response...
- Diagnosis and treatment of invasive pulmonary aspergillosis in neutropenic patients
Division of Pneumology, Dept of Internal Medicine, University Hospital Leipzig, Germany
Eur Respir J 19:743-55. 2002
..This paper analyses the current understanding of the pathogenesis and epidemiology of invasive aspergillosis and reviews the actual diagnostic and therapeutic strategies for invasive pulmonary aspergillosis in neutropenic patients...
- Clinical significance of lower respiratory tract Aspergillus culture in elderly hospitalized patients
A O Soubani
Division of Pulmonary, Critical Care and Sleep Medicine, Wayne State University School of Medicine, Harper University Hospital, 3990 John R 3 Hudson, Detroit, MI 48201, USA
Eur J Clin Microbiol Infect Dis 23:491-4. 2004
..and serious lung infection due to Aspergillus spp. was rare. Clinical, radiological, and microbiological data did not help differentiate between infection and colonization...
- Pulmonary cryptococcosis: CT findings in immunocompetent patients
Rebecca M Lindell
Department of Radiology, Mayo Clinic Rochester, 200 First St SW, Rochester, MN 55905, USA
Radiology 236:326-31. 2005
..To evaluate retrospectively the computed tomographic (CT) findings in immunocompetent patients with pulmonary cryptococcosis...
- Invasive aspergillosis. Disease spectrum, treatment practices, and outcomes. I3 Aspergillus Study Group
T F Patterson
Division of Infectious Diseases, University of Texas Health Science Center, San Antonio 78284 7881, USA
Medicine (Baltimore) 79:250-60. 2000
..New approaches and new therapies are needed to improve the outcome of invasive aspergillosis in high-risk patients...
- Diagnosis of invasive pulmonary aspergillosis using polymerase chain reaction-based detection of aspergillus in BAL
Department of Infectious Diseases, Infection Control and Employee Health, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
Chest 121:1171-6. 2002
..To assess the value of Aspergillus polymerase chain reaction (PCR) test performed on the BAL in diagnosing invasive pulmonary aspergillosis (IPA)...
- TLR1 and TLR6 polymorphisms are associated with susceptibility to invasive aspergillosis after allogeneic stem cell transplantation
Department of Medicine, Infectious Diseases Service, Memorial Sloan Kettering Cancer Center, 1275 York Ave, Box 9, New York, NY 10021, USA
Ann N Y Acad Sci 1062:95-103. 2005
..13 to 1.50; P < .001). Further analyses using a prospective cohort may enable us to identify TLR polymorphisms associated with the susceptibility to IA within a defined interval among immunocompromised patients...
- Detection of Aspergillus species DNA by PCR in bronchoalveolar lavage fluid
M P Hayette
Service de Microbiologie Médicale, Tour de Pathologie B23, Universite de Liege, B 4000 Liege, Belgium
J Clin Microbiol 39:2338-40. 2001
..However, it did not differentiate between infection and colonization...
- Comparison of six DNA extraction methods for recovery of fungal DNA as assessed by quantitative PCR
David N Fredricks
Program in Infectious Diseases, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
J Clin Microbiol 43:5122-8. 2005
..In conclusion, the six extraction methods produce markedly differing yields of fungal DNA and thus can significantly affect the results of fungal PCR assays. No single extraction method was optimal for all organisms...
- Isolation of Aspergillus in critically ill patients: a potential marker of poor outcome
Wayne State University Detroit Medical Center, Detroit, MI 48201, USA
J Crit Care 21:322-7. 2006
..The aim of this study was to determine the clinical significance of isolating Aspergillus from respiratory samples of critically ill patients...
- Detection of Aspergillus species in blood and bronchoalveolar lavage samples from immunocompromised patients by means of 2-step polymerase chain reaction: clinical results
III Medizinische Universitaetsklinik, Klinikum Mannheim, Fakultaet fuer Klinische Medizin Mannheim, Ruprecht Karls Universitaet Heidelberg, Mannheim, Germany
Clin Infect Dis 33:428-35. 2001
..Our data suggest that this PCR method has possible clinical value for confirming and improving the diagnosis of invasive aspergillosis in high-risk patients...
- Bronchoalveolar lavage galactomannan in diagnosis of invasive pulmonary aspergillosis among solid-organ transplant recipients
Cornelius J Clancy
Department of Medicine, University of Florida College of Medicine, Gainesville, FL 32610, USA
J Clin Microbiol 45:1759-65. 2007
..5%, respectively (cutoff, > or = 1.0). In conclusion, BAL GM testing facilitated more-rapid diagnoses of IPA and the institution of antifungal therapy among non-lung solid-organ transplant recipients and helped to rule out IPA...
- Public health surveillance for coccidioidomycosis in Arizona
Rebecca H Sunenshine
Arizona Department of Health Services, Phoenix, AZ 85007, USA
Ann N Y Acad Sci 1111:96-102. 2007
- Pulmonary blastomycosis: an appraisal of diagnostic techniques
Marek A Martynowicz
Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Mayo Medical School and Mayo Medical Center, Rochester, MN 55905 0001, USA
Chest 121:768-73. 2002
- Cluster of pulmonary blastomycosis in a rural community: evidence for multiple high-risk environmental foci following a sustained period of diminished precipitation
Mary E Proctor
Wisconsin Department at Health and Family Servcices, Division of Public Health, Bureau of Communicable Diseases, Madison 53701, USA
Mycopathologia 153:113-20. 2002
..Lymphocyte-proliferation assays of whole blood samples detected previously unrecognized infection with B. dermatititidis among five of 32 family controls...
- The radiological spectrum of pulmonary aspergillosis
Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
Med Mycol 43:S147-54. 2005
..Patients with a halo sign at baseline are more likely to have a satisfactory treatment response than those without this indicator...
- Development of a LightCycler PCR assay for detection and quantification of Aspergillus fumigatus DNA in clinical samples from neutropenic patients
III Medizinische Klinik, Universitatsklinikum Mannheim, University of Heidelberg, D 68305 Mannheim, Germany
J Clin Microbiol 41:1811-8. 2003
- Transient neutralization of tumor necrosis factor alpha can produce a chronic fungal infection in an immunocompetent host: potential role of immature dendritic cells
Amy C Herring
Pulmonary and Critical Care Medicine, 6301 MSRB III, The University of Michigan, Ann Arbor, MI 48109 0642, USA
Infect Immun 73:39-49. 2005
- Enhanced allergic inflammation and airway responsiveness in rats with chronic Cryptococcus neoformans infection: potential role for fungal pulmonary infection in the pathogenesis of asthma
David L Goldman
Department of Pediatrics, Albert Einstein College of Medicine, Bronx, New York 10461, USA
J Infect Dis 193:1178-86. 2006
..neoformans infection to potentiate allergic responses and airway reactivity and suggest a potential role for subclinical pulmonary cryptococcosis in the pathogenesis of asthma...
- Clinical relevance of Aspergillus isolation from respiratory tract samples in critically ill patients
Koenraad H Vandewoude
Department of Intensive Care, Ghent University Hospital, Ghent, Belgium
Crit Care 10:R31. 2006
- Pulmonary cryptococcosis: comparison of clinical and radiographic characteristics in immunocompetent and immunocompromised patients
Wei Chou Chang
Department of Radiology, Tri Service General Hospital, Nei Hu, Taipei 114, Taiwan, Republic of China
Chest 129:333-40. 2006
- F-18 fluorodeoxyglucose positron emission tomography in pulmonary cryptococcoma
Chung Huei Hsu
PET Center, Taiwan, ROC, USA
Clin Nucl Med 28:791-3. 2003
..Cryptococcoma was finally diagnosed. Hence, the CT scan and FDG PET played complementary roles in the differential diagnosis of this nodular mass...
- Role of extracellular phospholipases and mononuclear phagocytes in dissemination of cryptococcosis in a murine model
Centre for Infectious Diseases and Microbiology, University of Sydney at Westmead and Department of Infectious Diseases, Westmead Hospital, NSW 2145, Australia
Infect Immun 72:2229-39. 2004
..PLB is not, however, essential for the establishment of neurological infections when cryptococci are presented within, or after passage through, mononuclear phagocytes...
- Role of macrophages in host defense against aspergillosis and strategies for immune augmentation
Brahm H Segal
Division of Infectious Diseases, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, New York 14263, USA
Oncologist 12:7-13. 2007
..Macrophages are therefore a target for immune augmentation strategies that include administration of cytokines, colony-stimulating factors, and pathogen recognition receptor ligands...
- Role of granulocyte macrophage colony-stimulating factor in host defense against pulmonary Cryptococcus neoformans infection during murine allergic bronchopulmonary mycosis
Gwo Hsiao Chen
Division of Pulmonary and Critical Care Medicine, University of Michigan Medical School, Ann Arbor, MI 48109 0642, USA
Am J Pathol 170:1028-40. 2007
..Production of both Th1 and Th2 cytokines was impaired in the absence of GM-CSF, consistent with both reduced C. neoformans clearance and absence of allergic lung pathology...
- Pulmonary cryptococcosis in nonimmunocompromised patients
Hassan F Nadrous
Division of Pulmonary and Critical Care Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
Chest 124:2143-7. 2003
..However, isolated pulmonary cryptococcosis in nonimmunocompromised hosts has been reported to resolve spontaneously without treatment...
- A dual role for TGF-beta1 in the control and persistence of fungal pneumonia
Department of Pediatrics, Albert Einstein College of Medicine, Bronx, NY 10461, USA
J Immunol 175:6757-63. 2005
- Efficacy and toxicity of caspofungin in combination with liposomal amphotericin B as primary or salvage treatment of invasive aspergillosis in patients with hematologic malignancies
Dimitrios P Kontoyiannis
Department of Infectious Diseases, Infection Control and Employee Health, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
Cancer 98:292-9. 2003
..Therefore, the authors retrospectively evaluated the efficacy and toxicity of CAS plus liposomal amphotericin B (LipoAMB) in patients with documented (definite or probable) or possible IA...
- Persistent Cryptococcus neoformans pulmonary infection in the rat is associated with intracellular parasitism, decreased inducible nitric oxide synthase expression, and altered antibody responsiveness to cryptococcal polysaccharide
D L Goldman
Division of Infectious Diseases, Albert Einstein College of Medicine, Bronx, New York 10461, USA
Infect Immun 68:832-8. 2000
..neoformans; and (iv) reduced antibody responses to cryptococcal polysaccharide. The results show that maintenance of persistent infection is associated with downregulation of both cellular and humoral immune responses...
- Protective role of lung surfactant protein D in a murine model of invasive pulmonary aspergillosis
Centre for Biochemical Technology, Council for Scientific and Industrial Research, Delhi 110007, India
Infect Immun 69:2728-31. 2001
..Treatment with AmB, SP-D, and rSP-D increased the survival rate to 80, 60, and 80%, respectively, suggesting that SP-D (and rSP-D) can protect immunosuppressed mice from an otherwise fatal challenge with Aspergillus fumigatus conidia...
- An innate immune system cell is a major determinant of species-related susceptibility differences to fungal pneumonia
Department of Pediatrics, Albert Einstein College of Medicine, Bronx, NY 10461, USA
J Immunol 175:3244-51. 2005
..In summary, differences in AM function in rats and mice suggest an explanation for the species differences in susceptibility to C. neoformans based on the inherent efficacy of a central effector cell of the innate immune system...
- Phagocytic activity and monocyte chemotactic protein expression by pulmonary macrophages in persistent pulmonary cryptococcosis
Department of Pediatrics, Albert Einstein College of Medicine, Bronx, New York 10461, USA
Infect Immun 71:930-6. 2003
..Furthermore, we find that phagocytosis of C. neoformans can serve as an important stimulus for MCP-1 production by PuM, though the efficiency of this process is dependent on the opsonin type and may be affected by aging...
- Pulmonary cryptococcosis in patients without HIV infection
J A Aberg
AIDS Clinical Trials Unit, San Francisco General Hospital AIDS Program, University of California 94110, USA
Chest 115:734-40. 1999
..To further elucidate the diagnostic and therapeutic approaches to patients with pulmonary cryptococcosis who are not HIV-infected...
- Clinical evaluation of a polymerase chain reaction assay to detect Aspergillus species in bronchoalveolar lavage samples of neutropenic patients
III Medizinische Universitätsklinik, Klinikum Mannheim, Mannheim, Germany
Br J Haematol 116:803-11. 2002
..4%, the positive predictive value 83.8%, the negative predictive value 98.1%. Our data support the considerable clinical value of this PCR assay for confirming and improving diagnosis of pulmonary aspergillosis in high-risk patients...
- Aspergillus detection in bronchoscopically acquired material. Significance and interpretation
H J Seyfarth
Medizinische Klinik I, Abteilung Pneumologie, , Germany
Mycoses 44:356-60. 2001
..Cultivation of Aspergillus was more successful in BAL, and the Aspergillus antigen detection was more successful in BL...
Tom M Chiller
Division of Infectious Diseases, Department of Medicine, Santa Clara Valley Medical Center, 751 South Bascom Avenue, San Jose, CA 95128 2699, USA
Infect Dis Clin North Am 17:41-57, viii. 2003
..Coccidioides, a fungus, is endemic to specific parts of the Western Hemisphere. This article examines the prevalence, pathogenesis and host defense, clinical manifestations, diagnosis, and treatment of coccidioidomycosis...
- Inheritance of immune polarization patterns is linked to resistance versus susceptibility to Cryptococcus neoformans in a mouse model
Gwo Hsiao Chen
VA Medical Center Ann Arbor, Ann Arbor, MI 48105, USA
Infect Immun 76:2379-91. 2008
..The enhanced pulmonary lymphocyte recruitment could be responsible for a gradual shutdown of the undesirable Th2 arm of the immune response and subsequently improved anticryptococcal resistance in F1 mice...
- Immunoparalysis as a cause for invasive aspergillosis?
Koen J Hartemink
Department of Intensive Care, VU University Medical Center, PO Box 7057, 1007 MB, Amsterdam, The Netherlands
Intensive Care Med 29:2068-71. 2003
..Physicians treating critically ill patients in the ICU should be aware of the CARS/immunoparalysis syndrome and its potential to cause opportunistic infections, even in patients with normal immune function prior to ICU admission...
- The value of the chest computed tomography halo sign in the diagnosis of invasive pulmonary aspergillosis. An autopsy-based retrospective study of 48 patients
Department of Hematology, Toranomon Hospital, Tokyo, Japan
Mycoses 45:287-94. 2002
..For CT findings other than these three signs, there were no significant differences between IPA- and non-IPA patients...
- [A case of allergic bronchopulmonary mycosis caused by Schizophyllum commune]
Third Department of Internal Medicine, Faculty of Medicine, Tottori University
Arerugi 51:439-42. 2002
- Interleukin-4 causes susceptibility to invasive pulmonary aspergillosis through suppression of protective type I responses
Microbiology Section, Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Perugia, Italy
J Infect Dis 180:1957-68. 1999
..fumigatus by inhibition of protective Th1 responses. IL-4 appears to have a distinct role in the pathogenesis of allergic and nonallergic lung diseases caused by the fungus...
- State-of-the-art review of pulmonary fungal infections
L Joseph Wheat
Indiana University School of Medicine, Indianapolis Department of Veterans Affairs Hospital, USA
Semin Respir Infect 17:158-81. 2002
..The lung is the portal of entry for most of these pathogens, and often is prominently involved in the clinical syndrome. This article focuses on the recognition, diagnosis, and management of these important pulmonary mycoses...
- Invasive pulmonary aspergillosis: frequency and meaning of the "hypodense sign" on unenhanced CT
Department of Diagnostic Radiology, Eberhard Karls University, Hoppe Seyler Strasse 3, 72076 Tubingen
Br J Radiol 78:697-703. 2005
..The hypodense sign is recognizable also on unenhanced CT, when a narrower lung window setting is used...
- Pulmonary cryptococcosis: CT and pathologic findings
Steven E Zinck
Department of Radiology, University of British Columbia, Vancouver, Canada
J Comput Assist Tomogr 26:330-4. 2002
..The purpose of this work was to describe the CT and pathologic findings of pulmonary cryptococcosis...
- Chronic necrotizing pulmonary aspergillosis in pneumoconiosis: clinical and radiologic findings in 10 patients
Department of Internal Medicine, Asahi Rosai Hospital, Aichi, Japan
Chest 121:118-27. 2002
..To characterize clinical, radiographic, and CT findings of chronic necrotizing pulmonary aspergillosis (CNPA) in patients with pneumoconiosis...
- Refractory Aspergillus pneumonia in patients with acute leukemia: successful therapy with combination caspofungin and liposomal amphotericin
Timothy B Aliff
Leukemia Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
Cancer 97:1025-32. 2003
..The authors treated a group of patients with amphotericin-refractory IFIs with the combination of caspofungin and amphotericin (or liposomal amphotericin)...
- The radiology of pulmonary cryptococcosis in a tertiary medical center
J M Lacomis
Department of Radiology, University of Pittsburgh Medical Center, PA 15213, USA
J Thorac Imaging 16:139-48. 2001
..Chest computed tomography (CT) contributes to a more comprehensive understanding of pulmonary cryptococcal infections...
- Semiquantitative detection by real-time PCR of Aspergillus fumigatus in bronchoalveolar lavage fluids and tissue biopsy specimens from patients with invasive aspergillosis
Department of Medical Microbiology, University of Turku, Finland
J Clin Microbiol 41:4304-11. 2003
..fumigatus. Semiquantitative detection of A. fumigatus mtDNA in BAL fluid may be helpful in the diagnosis of IPA. PCR is well suited for the verification of the presence of A. fumigatus in tissue biopsy specimens...
- Invasive pulmonary aspergillosis in chronic obstructive pulmonary disease: an emerging fungal pathogen
Service de Réanimation Médicale et Maladies Infectieuses, CH de Tourcoing, Tourcoing, France
Clin Microbiol Infect 11:427-9. 2005
..Survival depends on rapid diagnosis and early appropriate treatment. A decrease or interruption of steroid treatment should be considered as part of the overall therapeutic strategy...
- A large outbreak of histoplasmosis among American travelers associated with a hotel in Acapulco, Mexico, spring 2001
Mycotic Diseases Branch, Division of Bacterial and Mycotic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
Am J Trop Med Hyg 69:663-9. 2003
..7-30.5; P < 0.001). This is the first histoplasmosis outbreak associated with a hotel undergoing construction. Hotels in endemic areas should consider construction precaution measures to prevent histoplasmosis among their guests...
- An outbreak of acute pulmonary histoplasmosis in members of a trekking trip in Martinique, French West Indies
Department of Infectious Diseases and Internal Medicine, Raymond Poincare University Hospital, 104 boulevard Raymond Poincaré, 92 380 Garches, France
J Travel Med 10:87-93. 2003
..The 12 others performed canyoning and did not go through the tunnel (control group). Fifteen days after exposure, 1 patient of the tunnel group developed fever, chills, and cough...
- A case of invasive pulmonary aspergillosis in renal failure
Anders O Sahlén
Nephrol Dial Transplant 19:2687. 2004
- Coccidioidomycosis: a descriptive survey of a reemerging disease. Clinical characteristics and current controversies
Nancy F Crum
Clinical Investigation Department, Infectious Disease Division, Naval Medical Center San Diego, San Diego, California 92134 1005, USA
Medicine (Baltimore) 83:149-75. 2004
..Azole therapy was generally inferior to amphotericin B in disseminated disease. Predictors of permanent disability included African American or Filipino race, central nervous system disease, and bony disease...
- Value of an inhalational model of invasive aspergillosis
William J Steinbach
Division of Pediatric Infectious Diseases, Box 3499, Duke University Medical Center, Durham, NC 27710, USA
Med Mycol 42:417-25. 2004
- Mutation of the WI-1 gene yields an attenuated blastomyces dermatitidis strain that induces host resistance
Department of Pediatrics, The Comprehensive Cancer Center, University of Wisconsin Medical School, University of Wisconsin Hospital, Madison, USA
J Clin Invest 106:1381-9. 2000
..Thus, by mutating a pathogenetic locus in a dimorphic fungus, we have created an attenuated vaccine strain and have begun to elucidate fungal and host elements requisite for vaccine immunity...
- Triazole-polyene antagonism in experimental invasive pulmonary aspergillosis: in vitro and in vivo correlation
Immunocompromised Host Section, Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA
J Infect Dis 194:1008-18. 2006
..No pharmacokinetic interaction was found. The combination of a triazole and polyene may be antagonistic in the treatment of invasive pulmonary aspergillosis...
- Paradoxical increase in circulating Aspergillus antigen during treatment with caspofungin in a patient with pulmonary aspergillosis
Rocus R Klont
Department of Medical Microbiology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
Clin Infect Dis 43:e23-5. 2006
..With the exception of treatment with the echinocandin, no other factors were found that might explain this clinical observation, which was supported by experiments done in vitro...
- [Successful treatment by voliconazole for pulmonary and adductor magnus muscle aspergillosis induced by immunosuppressive therapy for hypersensitivity pneumonia]
Department of Respiratory Medicine, Faculty of Medical and Pharmaceutical Sciences, Kumamoto University
Nihon Kokyuki Gakkai Zasshi 44:754-60. 2006
..Furthermore, the high level of beta-D glucan in serum decreased gradually. This case suggests that administration of VCZ can be recommended for deep seated mycoses...
- Efficacy of micafungin alone or in combination against experimental pulmonary aspergillosis
Karl V Clemons
California Institute for Medical Research, San Jose, CA 95128, USA
Med Mycol 44:69-73. 2006
..Overall, these results indicate that MICA has moderate activity against pulmonary aspergillosis and might be useful in combination with conventional AMB...
- Disseminated invasive aspergillosis in a patient with acute leukaemia
Department of Medicine, Landspitali University Hospital, Fossvogur, 101 Reykjavik, Iceland
Acta Biomed 77:10-3. 2006
..The patient died one week following the diagnosis of aspergillosis...
- Antifungal prophylaxis is effective against murine invasive pulmonary aspergillosis
Antimicrob Agents Chemother 50:2895-6. 2006
- Characterization and comparison of galactomannan enzyme immunoassay and quantitative real-time PCR assay for detection of Aspergillus fumigatus in bronchoalveolar lavage fluid from experimental invasive pulmonary aspergillosis
Immunocompromised Host Section, Pediatric Oncology Branch, National Cancer Institute, Bldg 10 CRC, Rm 1 5740, Bethesda, MD 20892, USA
J Clin Microbiol 44:2475-80. 2006
..04). Use of the GM EIA and qPCR assay in conjunction with culture-based diagnostic methods applied to BAL fluid could facilitate accurate diagnosis and more-timely initiation of specific therapy...
- Successful major surgical recovery of a patient following haploidentical stem cell transplantation for chronic myeloid leukemia in blast crisis and aspergillosis
Department of Bone Marrow Transplantation, Hadassah University Hospital, Jerusalem, Israel
Acta Haematol 108:29-32. 2002
..Most notably, normal and fast recovery was observed following major surgery 7 months post-haplo SCT which is usually considered to result in long-lasting immunosuppression and malfunction of the immune system...
- Radiological resolution of cavitating Aspergillus fumigatus infection following treatment with oral voriconazole in two lung transplant recipients
Transpl Int 19:688-90. 2006
- Multi-azole resistance in Aspergillus fumigatus
Susan J Howard
School of Medicine, The University of Manchester, Oxford Road, Manchester M13 9PL, UK
Int J Antimicrob Agents 28:450-3. 2006
..The patient had some response to intravenous caspofungin, which he received six times weekly, without the development of resistance over 9 months...
- Efficient clearance of Aspergillus fumigatus in murine lungs by an ultrashort antimicrobial lipopeptide, palmitoyl-lys-ala-DAla-lys
Department of Biological Chemistry, Weizmann Institute of Science, Rehovot 76100, Israel
Antimicrob Agents Chemother 52:3118-26. 2008
..Our results highlight the potential of this family of lipopeptides for the treatment of pulmonary invasive aspergillosis...
- [Clinical cases in medical mycology. Case no. 32]
Unidad de Micologia, Hospital de Infecciosas Francisco Javier Muniz, Uspallata 2272 1282, Buenos Aires, Argentina
Rev Iberoam Micol 25:65-7. 2008
- [Cutaneous, pulmonary and bone aspergillosis in a patient presumed immunocompetent presenting subacute cutaneous lupus erythematosus]
Service de Dermatologie, Hopital Haut Leveque, CHU de Bordeaux, 1, Avenue de Magellan, 33604 Pessac Cedex, France
Ann Dermatol Venereol 135:217-21. 2008
..We report a case of cutaneous, pulmonary and bone aspergillosis successfully treated after many years of progression in a patient presumed immunocompetent presenting subacute cutaneous lupus erythematosus...
- Assessment of serum (1->3)-beta-D-glucan concentration as a measure of disease burden in a murine model of invasive pulmonary aspergillosis
Nathan P Wiederhold
The University of Texas at Austin College of Pharmacy, Austin, Texas, USA
Antimicrob Agents Chemother 52:1176-8. 2008
..Serum (1-->3)-beta-D-glucan was detected early during the course of infection, and reductions in this biomarker were associated with improved survival in animals treated with antifungal agents...
- [Breakthrough pulmonary mucormycosis during voriconazole treatment after reduced-intensity cord blood transplantation for a patient with acute myeloid leukemia]
Division of Gastroenterology and Hematology Oncology, Department of Medicine, Asahikawa Medical College
Rinsho Ketsueki 48:412-7. 2007
..These findings suggest that it is very important to pay attention to mucormycosis in hematopoietic stem cell transplant recipients in this country...
- [Pulmonary mucormycosis: difficulties in diagnosis and treatment]
Service de Pneumologie, Centre Hospitalo Universitaire de Nantes, France
Rev Mal Respir 24:617-21. 2007
..Gastro-intestinal, cutaneous and disseminated disease is less common. The principal risk factors are immuno-suppression and diabetic keto-acidosis...
- Sinopulmonary aspergillosis in children with hematological malignancy
Division of Pediatric Hematology, Department of Pediatrics, Celal Bayar University Faculty of Medicine Manisa, Turkey
Minerva Pediatr 58:319-24. 2006
..Early diagnosis, appropriate treatment and primary disease status are important factors on prognosis of Aspergillus infections in children with hematological malignancy...
- Aerosolized nanostructured itraconazole as prophylaxis against invasive pulmonary aspergillosis
Carlos A Alvarez
The University of Texas at Austin College of Pharmacy, 1 University Station, A1900, Austin, TX 78712, USA
J Infect 55:68-74. 2007
..We evaluated the effectiveness of an aerosolized nanostructured formulation of itraconazole produced by spray freezing into liquid (SFL) as prophylaxis against invasive pulmonary aspergillosis caused by A. fumigatus...
- Invasive pulmonary aspergillosis associated with marijuana use in a man with colorectal cancer
David W Cescon
Department of Medicine, University of Toronto, Toronto, Canada
J Clin Oncol 26:2214-5. 2008
- Assessment of Aspergillus fumigatus burden in pulmonary tissue of guinea pigs by quantitative PCR, galactomannan enzyme immunoassay, and quantitative culture
Ana C Vallor
The University of Texas Health Science Center at San Antonio, Department of Medicine, Division of Infectious Diseases, 7703 Floyd Curl Drive, Mail Code 7881, San Antonio, TX 78229 3900, USA
Antimicrob Agents Chemother 52:2593-8. 2008
..02). Confirmation of fungal tissue burden by two or more methods should provide a more precise account of the burden, allowing improved assessment of diagnostic and therapeutic strategies in invasive pulmonary aspergillosis...
- Efficacy of intravenous itraconazole against invasive pulmonary aspergillosis in neutropenic mice
Department of Microbiology and Immunology, University of Teikyo, School of Medicine, 2 11 1 Kaga, Itabashi ku, Tokyo 173 8605, Japan
J Infect Chemother 12:355-62. 2006
..fumigatus (0.16 microg/ml). These results support the clinical usefulness of ITZ-IV for the treatment of IPA in immunocompromised patients...
- Double invasive fungal infection and typhlitis in children with acute lymphoblastic leukemia
Department of Pediatric Hematology, Baskent University Faculty of Medicine, Ankara, Turkey
Pediatr Hematol Oncol 25:99-106. 2008
..They were treated with liposomal amphotericin B, but one of them died due to massive pulmonary hemorrhage during recovery from neutropenia...
- Pathogenesis of Aspergillus fumigatus and the kinetics of galactomannan in an in vitro model of early invasive pulmonary aspergillosis: implications for antifungal therapy
William W Hope
Immunocompromised Host Section, Pediatric Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
J Infect Dis 195:455-66. 2007
..Little is known about the pathogenesis of invasive pulmonary aspergillosis and the relationship between the kinetics of diagnostic markers and the outcome of antifungal therapy...
- Imaging findings in acute invasive pulmonary aspergillosis: clinical significance of the halo sign
Reginald E Greene
Massachusetts General Hospital, Boston, MA 02114, USA
Clin Infect Dis 44:373-9. 2007
- Caspofungin prolongs survival of transiently neutropenic rats with advanced-stage invasive pulmonary aspergillosis
Wendy W J van de Sande
Erasmus MC, University Medical Center Rotterdam, Department of Medical Microbiology and Infectious Diseases, s Gravendijkwal 230, 3015 CE, Rotterdam, The Netherlands
Antimicrob Agents Chemother 52:1345-50. 2008
..In this model, the administration of high-dose-step-down treatment was as effective as treatment with high doses for the whole treatment period...
- Itraconazole preexposure attenuates the efficacy of subsequent amphotericin B therapy in a murine model of acute invasive pulmonary aspergillosis
Russell E Lewis
Department of Infectious Diseases, Infection Control, and Employee Health, The University of Texas M D Anderson Cancer Center, Houston 77030, USA
Antimicrob Agents Chemother 46:3208-14. 2002
..03). Higher doses of AMB did not overcome this antagonism. ITC preexposure was associated with poorer mycological efficacy and survival in mice treated subsequently with AMB for invasive pulmonary aspergillosis...
- [Dystrophic calcification in the brain after successful treatment of invasive aspergillosis]
Sección de Neurorradiología, Hospital Universitario Doce de Octubre, Madrid, Spain
Rev Neurol 39:492-3. 2004
- Pharmacodynamics of caspofungin in a murine model of invasive pulmonary aspergillosis: evidence of concentration-dependent activity
Nathan P Wiederhold
The University of Houston College of Pharmacy and The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
J Infect Dis 190:1464-71. 2004
..We conducted a dosage-fractionation study to characterize the in vivo pharmacodynamics of CAS activity during IPA, using immunosuppressed mice inoculated intranasally with Aspergillus fumigatus...
- Efficacy of voriconazole plus amphotericin B or micafungin in a guinea-pig model of invasive pulmonary aspergillosis
P H Chandrasekar
Division of Infectious Diseases, Department of Internal Medicine, Wayne State University School of Medicine, Detroit, MI 48201, USA
Clin Microbiol Infect 10:925-8. 2004
..Further studies of efficacy, dosing and optimal regimens for antifungal combinations are warranted...