fungal lung diseases

Summary

Top Publications

  1. ncbi Pulmonary fungal infection: emphasis on microbiological spectra, patient outcome, and prognostic factors
    K Y Chen
    Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan
    Chest 120:177-84. 2001
  2. ncbi Dynamic changes in the morphology of Cryptococcus neoformans during murine pulmonary infection
    M Feldmesser
    Department of Medicine, Division of Infectious Diseases, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Microbiology 147:2355-65. 2001
  3. ncbi Increasing volume and changing characteristics of invasive pulmonary aspergillosis on sequential thoracic computed tomography scans in patients with neutropenia
    D Caillot
    Department of Clinical Hematology, University Hospital of Dijon, Dijon, France
    J Clin Oncol 19:253-9. 2001
  4. ncbi Combination therapy in treatment of experimental pulmonary aspergillosis: synergistic interaction between an antifungal triazole and an echinocandin
    Vidmantas Petraitis
    Immunocompromised Host Section, Pediatric Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Infect Dis 187:1834-43. 2003
  5. pmc Management of invasive pulmonary aspergillosis in non-neutropenic critically ill patients
    R J Trof
    Department of Intensive Care, VU Medical Centre, De Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands
    Intensive Care Med 33:1694-703. 2007
  6. ncbi Distinct roles for IL-4 and IL-10 in regulating T2 immunity during allergic bronchopulmonary mycosis
    Yadira Hernandez
    Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor 48109, USA
    J Immunol 174:1027-36. 2005
  7. ncbi Detection of galactomannan antigenemia by enzyme immunoassay for the diagnosis of invasive aspergillosis: variables that affect performance
    Kieren A Marr
    Fred Hutchinson Cancer Research Center and University of Washington, Seattle, Washington 98109, USA
    J Infect Dis 190:641-9. 2004
  8. ncbi A systematic literature review on the diagnosis of invasive aspergillosis using polymerase chain reaction (PCR) from bronchoalveolar lavage clinical samples
    Felipe Francisco Tuon
    Department of Infectious Diseases, Hospital das Clinicas, Faculdade de Medicina da Universidade de Sao Paulo, Brazil
    Rev Iberoam Micol 24:89-94. 2007
  9. pmc Aspergillus galactomannan enzyme immunoassay and quantitative PCR for diagnosis of invasive aspergillosis with bronchoalveolar lavage fluid
    Benjamin Musher
    University of Washington, Seattle, WA, USA
    J Clin Microbiol 42:5517-22. 2004
  10. ncbi Pulmonary cryptococcosis in immunocompetent patients: CT findings in 12 patients
    Danial L Fox
    Department of Radiology, Vancouver General Hospital, Vancouver, BC V5Z 1M9, Canada
    AJR Am J Roentgenol 185:622-6. 2005

Research Grants

Detail Information

Publications203 found, 100 shown here

  1. ncbi Pulmonary fungal infection: emphasis on microbiological spectra, patient outcome, and prognostic factors
    K Y Chen
    Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan
    Chest 120:177-84. 2001
    ..Early diagnosis with prompt antifungal therapy, or even with surgical intervention, might be warranted to save patients' lives...
  2. ncbi Dynamic changes in the morphology of Cryptococcus neoformans during murine pulmonary infection
    M Feldmesser
    Department of Medicine, Division of Infectious Diseases, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Microbiology 147:2355-65. 2001
    ..The results indicate that the population of C. neoformans cells in tissue is in a highly dynamic state, implying that the immune system must confront cells with varying characteristics during the course of infection...
  3. ncbi Increasing volume and changing characteristics of invasive pulmonary aspergillosis on sequential thoracic computed tomography scans in patients with neutropenia
    D Caillot
    Department of Clinical Hematology, University Hospital of Dijon, Dijon, France
    J Clin Oncol 19:253-9. 2001
    ..In patients with neutropenia, thoracic computed tomography (CT) halo and air-crescent signs are recognized as major indicators of invasive pulmonary aspergillosis (IPA). Nevertheless, the exact timing of CT images is not well known...
  4. ncbi Combination therapy in treatment of experimental pulmonary aspergillosis: synergistic interaction between an antifungal triazole and an echinocandin
    Vidmantas Petraitis
    Immunocompromised Host Section, Pediatric Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Infect Dis 187:1834-43. 2003
    ..The combination of an antifungal triazole and echinocandin may represent a new strategy for treatment of invasive pulmonary aspergillosis...
  5. pmc Management of invasive pulmonary aspergillosis in non-neutropenic critically ill patients
    R J Trof
    Department of Intensive Care, VU Medical Centre, De Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands
    Intensive Care Med 33:1694-703. 2007
    ..The benefit of combination antifungal therapy lacks sufficient evidence so far, but this treatment might be considered in patients with breakthrough infections or refractory disease...
  6. ncbi Distinct roles for IL-4 and IL-10 in regulating T2 immunity during allergic bronchopulmonary mycosis
    Yadira Hernandez
    Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor 48109, USA
    J Immunol 174:1027-36. 2005
    ..Thus, although IL-10 has been reported to down-regulate pulmonary T2 responses to isolated fungal Ags, IL-10 can augment pulmonary T2 responses if they occur in the context of fungal infection...
  7. ncbi Detection of galactomannan antigenemia by enzyme immunoassay for the diagnosis of invasive aspergillosis: variables that affect performance
    Kieren A Marr
    Fred Hutchinson Cancer Research Center and University of Washington, Seattle, Washington 98109, USA
    J Infect Dis 190:641-9. 2004
    ..The 0.5 cutoff may allow for better performance as an early diagnostic test...
  8. ncbi A systematic literature review on the diagnosis of invasive aspergillosis using polymerase chain reaction (PCR) from bronchoalveolar lavage clinical samples
    Felipe Francisco Tuon
    Department of Infectious Diseases, Hospital das Clinicas, Faculdade de Medicina da Universidade de Sao Paulo, Brazil
    Rev Iberoam Micol 24:89-94. 2007
    ..The present study showed support for the clinical value of PCR from BAL for the diagnosis of invasive aspergillosis in patients with risk factors for this disease...
  9. pmc Aspergillus galactomannan enzyme immunoassay and quantitative PCR for diagnosis of invasive aspergillosis with bronchoalveolar lavage fluid
    Benjamin Musher
    University of Washington, Seattle, WA, USA
    J Clin Microbiol 42:5517-22. 2004
    ..GM EIA and qPCR assay add to the sensitivity of BAL for diagnosing IPA in high-risk patients, with excellent specificity. Adjunctive use of these tests may reduce dependence on invasive diagnostic procedures...
  10. ncbi Pulmonary cryptococcosis in immunocompetent patients: CT findings in 12 patients
    Danial L Fox
    Department of Radiology, Vancouver General Hospital, Vancouver, BC V5Z 1M9, Canada
    AJR Am J Roentgenol 185:622-6. 2005
    ..The aim of our study was to review the CT findings of pulmonary cryptococcosis in 12 immunocompetent patients...
  11. ncbi Blastomycosis
    Robert W Bradsher
    University of Arkansas for Medical Sciences, Central Arkansas Veterans Administration, Little Rock, AR, USA
    Infect Dis Clin North Am 17:21-40, vii. 2003
    ..Itraconazole has been shown to be the drug of choice for both infections, except in cases of life-threatening infection when amphotericin B should be used...
  12. ncbi Characteristics of integrated 18F-FDG PET/CT in Pulmonary Cryptococcosis
    Chung Jen Huang
    Division of Pulmonary and Intensive Care Medicine, Koo Foundation Sun Yat Sen Cancer Center, Taipei, Taiwan
    Acta Radiol 50:374-8. 2009
    ..Pulmonary cryptococcosis is an uncommon cause of pulmonary nodules found by (18)F-fluorodeoxyglucose positron emission tomography/computed tomography ((18)F-FDG PET/CT) scans. It is rarely reported but may mislead interpretation...
  13. ncbi IL-13 induces disease-promoting type 2 cytokines, alternatively activated macrophages and allergic inflammation during pulmonary infection of mice with Cryptococcus neoformans
    Uwe Muller
    Institute of Immunology, College of Veterinary Medicine, University of Leipzig, Leipzig, Germany
    J Immunol 179:5367-77. 2007
    ..This indicates that IL-13 contributes to fatal allergic inflammation during C. neoformans infection...
  14. ncbi Evaluation of the role of real-time PCR in the diagnosis of invasive aspergillosis
    R B Ferns
    Royal Free and University College Medical School, University College London, Division of Infection and Immunity, Department of Infection, Centre of Virology, London, UK
    Leuk Lymphoma 47:15-20. 2006
    ..The effect of anti-fungal treatment is noted. The requirement for both international standards and a consensus protocol that is sensitive enough for IA diagnosis, particularly in blood, is discussed...
  15. ncbi Significance of Aspergillus fumigatus isolation from respiratory specimens of nongranulocytopenic patients
    M L Uffredi
    Service de Pneumologie, Hopital Tenon, 4 rue de la Chine, 75020 Paris, France
    Eur J Clin Microbiol Infect Dis 22:457-62. 2003
    ....
  16. ncbi Invasive pulmonary and central nervous system aspergillosis after near-drowning of a child: case report and review of the literature
    Piet Leroy
    Division of Pediatric Intensive Care, Department of Pediatrics, University Hospital Maastricht, PO Box 5800, 6202 AZ Maastricht, Netherlands
    Pediatrics 118:e509-13. 2006
    ..Currently voriconazole, eventually in combination with caspofungin, should be considered as the drug of choice in the management of invasive aspergillosis after near-drowning...
  17. ncbi Chronic obstructive pulmonary disease patients with invasive pulmonary aspergillosis: benefits of intensive care?
    P A Bulpa
    Department of Intensive Care, Mont Godinne University Hospital, Universite Catholique de Louvain, Yvoir, Belgium
    Intensive Care Med 27:59-67. 2001
    ..For these patients admission in intensive care unit (ICU) is often required for life-support and mechanical ventilation. Whether this approach improves outcome is unknown...
  18. ncbi Neutropenia alters lung cytokine production in mice and reduces their susceptibility to pulmonary cryptococcosis
    Aron J Mednick
    Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY, USA
    Eur J Immunol 33:1744-53. 2003
    ..Our results support the emerging concept that neutrophils play an important function in modulating the development of the immune response...
  19. ncbi Diagnosis and treatment of invasive pulmonary aspergillosis in neutropenic patients
    F Reichenberger
    Division of Pneumology, Dept of Internal Medicine, University Hospital Leipzig, Germany
    Eur Respir J 19:743-55. 2002
    ..This paper analyses the current understanding of the pathogenesis and epidemiology of invasive aspergillosis and reviews the actual diagnostic and therapeutic strategies for invasive pulmonary aspergillosis in neutropenic patients...
  20. ncbi Clinical significance of lower respiratory tract Aspergillus culture in elderly hospitalized patients
    A O Soubani
    Division of Pulmonary, Critical Care and Sleep Medicine, Wayne State University School of Medicine, Harper University Hospital, 3990 John R 3 Hudson, Detroit, MI 48201, USA
    Eur J Clin Microbiol Infect Dis 23:491-4. 2004
    ..and serious lung infection due to Aspergillus spp. was rare. Clinical, radiological, and microbiological data did not help differentiate between infection and colonization...
  21. ncbi Pulmonary cryptococcosis: CT findings in immunocompetent patients
    Rebecca M Lindell
    Department of Radiology, Mayo Clinic Rochester, 200 First St SW, Rochester, MN 55905, USA
    Radiology 236:326-31. 2005
    ..To evaluate retrospectively the computed tomographic (CT) findings in immunocompetent patients with pulmonary cryptococcosis...
  22. ncbi Invasive aspergillosis. Disease spectrum, treatment practices, and outcomes. I3 Aspergillus Study Group
    T F Patterson
    Division of Infectious Diseases, University of Texas Health Science Center, San Antonio 78284 7881, USA
    Medicine (Baltimore) 79:250-60. 2000
    ..New approaches and new therapies are needed to improve the outcome of invasive aspergillosis in high-risk patients...
  23. ncbi Diagnosis of invasive pulmonary aspergillosis using polymerase chain reaction-based detection of aspergillus in BAL
    Issam Raad
    Department of Infectious Diseases, Infection Control and Employee Health, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Chest 121:1171-6. 2002
    ..To assess the value of Aspergillus polymerase chain reaction (PCR) test performed on the BAL in diagnosing invasive pulmonary aspergillosis (IPA)...
  24. ncbi TLR1 and TLR6 polymorphisms are associated with susceptibility to invasive aspergillosis after allogeneic stem cell transplantation
    Sandra Kesh
    Department of Medicine, Infectious Diseases Service, Memorial Sloan Kettering Cancer Center, 1275 York Ave, Box 9, New York, NY 10021, USA
    Ann N Y Acad Sci 1062:95-103. 2005
    ..13 to 1.50; P < .001). Further analyses using a prospective cohort may enable us to identify TLR polymorphisms associated with the susceptibility to IA within a defined interval among immunocompromised patients...
  25. pmc Detection of Aspergillus species DNA by PCR in bronchoalveolar lavage fluid
    M P Hayette
    Service de Microbiologie Médicale, Tour de Pathologie B23, Universite de Liege, B 4000 Liege, Belgium
    J Clin Microbiol 39:2338-40. 2001
    ..However, it did not differentiate between infection and colonization...
  26. pmc Comparison of six DNA extraction methods for recovery of fungal DNA as assessed by quantitative PCR
    David N Fredricks
    Program in Infectious Diseases, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    J Clin Microbiol 43:5122-8. 2005
    ..In conclusion, the six extraction methods produce markedly differing yields of fungal DNA and thus can significantly affect the results of fungal PCR assays. No single extraction method was optimal for all organisms...
  27. ncbi Isolation of Aspergillus in critically ill patients: a potential marker of poor outcome
    Faisal Khasawneh
    Wayne State University Detroit Medical Center, Detroit, MI 48201, USA
    J Crit Care 21:322-7. 2006
    ..The aim of this study was to determine the clinical significance of isolating Aspergillus from respiratory samples of critically ill patients...
  28. ncbi Detection of Aspergillus species in blood and bronchoalveolar lavage samples from immunocompromised patients by means of 2-step polymerase chain reaction: clinical results
    D Buchheidt
    III Medizinische Universitaetsklinik, Klinikum Mannheim, Fakultaet fuer Klinische Medizin Mannheim, Ruprecht Karls Universitaet Heidelberg, Mannheim, Germany
    Clin Infect Dis 33:428-35. 2001
    ..Our data suggest that this PCR method has possible clinical value for confirming and improving the diagnosis of invasive aspergillosis in high-risk patients...
  29. pmc Bronchoalveolar lavage galactomannan in diagnosis of invasive pulmonary aspergillosis among solid-organ transplant recipients
    Cornelius J Clancy
    Department of Medicine, University of Florida College of Medicine, Gainesville, FL 32610, USA
    J Clin Microbiol 45:1759-65. 2007
    ..5%, respectively (cutoff, > or = 1.0). In conclusion, BAL GM testing facilitated more-rapid diagnoses of IPA and the institution of antifungal therapy among non-lung solid-organ transplant recipients and helped to rule out IPA...
  30. ncbi Public health surveillance for coccidioidomycosis in Arizona
    Rebecca H Sunenshine
    Arizona Department of Health Services, Phoenix, AZ 85007, USA
    Ann N Y Acad Sci 1111:96-102. 2007
    ....
  31. ncbi Pulmonary blastomycosis: an appraisal of diagnostic techniques
    Marek A Martynowicz
    Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Mayo Medical School and Mayo Medical Center, Rochester, MN 55905 0001, USA
    Chest 121:768-73. 2002
    ....
  32. ncbi Cluster of pulmonary blastomycosis in a rural community: evidence for multiple high-risk environmental foci following a sustained period of diminished precipitation
    Mary E Proctor
    Wisconsin Department at Health and Family Servcices, Division of Public Health, Bureau of Communicable Diseases, Madison 53701, USA
    Mycopathologia 153:113-20. 2002
    ..Lymphocyte-proliferation assays of whole blood samples detected previously unrecognized infection with B. dermatititidis among five of 32 family controls...
  33. ncbi The radiological spectrum of pulmonary aspergillosis
    R Greene
    Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Med Mycol 43:S147-54. 2005
    ..Patients with a halo sign at baseline are more likely to have a satisfactory treatment response than those without this indicator...
  34. pmc Development of a LightCycler PCR assay for detection and quantification of Aspergillus fumigatus DNA in clinical samples from neutropenic patients
    Birgit Spiess
    III Medizinische Klinik, Universitatsklinikum Mannheim, University of Heidelberg, D 68305 Mannheim, Germany
    J Clin Microbiol 41:1811-8. 2003
    ....
  35. pmc Transient neutralization of tumor necrosis factor alpha can produce a chronic fungal infection in an immunocompetent host: potential role of immature dendritic cells
    Amy C Herring
    Pulmonary and Critical Care Medicine, 6301 MSRB III, The University of Michigan, Ann Arbor, MI 48109 0642, USA
    Infect Immun 73:39-49. 2005
    ....
  36. ncbi Enhanced allergic inflammation and airway responsiveness in rats with chronic Cryptococcus neoformans infection: potential role for fungal pulmonary infection in the pathogenesis of asthma
    David L Goldman
    Department of Pediatrics, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Infect Dis 193:1178-86. 2006
    ..neoformans infection to potentiate allergic responses and airway reactivity and suggest a potential role for subclinical pulmonary cryptococcosis in the pathogenesis of asthma...
  37. pmc Clinical relevance of Aspergillus isolation from respiratory tract samples in critically ill patients
    Koenraad H Vandewoude
    Department of Intensive Care, Ghent University Hospital, Ghent, Belgium
    Crit Care 10:R31. 2006
    ....
  38. ncbi Pulmonary cryptococcosis: comparison of clinical and radiographic characteristics in immunocompetent and immunocompromised patients
    Wei Chou Chang
    Department of Radiology, Tri Service General Hospital, Nei Hu, Taipei 114, Taiwan, Republic of China
    Chest 129:333-40. 2006
    ....
  39. ncbi F-18 fluorodeoxyglucose positron emission tomography in pulmonary cryptococcoma
    Chung Huei Hsu
    PET Center, Taiwan, ROC, USA
    Clin Nucl Med 28:791-3. 2003
    ..Cryptococcoma was finally diagnosed. Hence, the CT scan and FDG PET played complementary roles in the differential diagnosis of this nodular mass...
  40. pmc Role of extracellular phospholipases and mononuclear phagocytes in dissemination of cryptococcosis in a murine model
    Rosemary Santangelo
    Centre for Infectious Diseases and Microbiology, University of Sydney at Westmead and Department of Infectious Diseases, Westmead Hospital, NSW 2145, Australia
    Infect Immun 72:2229-39. 2004
    ..PLB is not, however, essential for the establishment of neurological infections when cryptococci are presented within, or after passage through, mononuclear phagocytes...
  41. ncbi Role of macrophages in host defense against aspergillosis and strategies for immune augmentation
    Brahm H Segal
    Division of Infectious Diseases, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, New York 14263, USA
    Oncologist 12:7-13. 2007
    ..Macrophages are therefore a target for immune augmentation strategies that include administration of cytokines, colony-stimulating factors, and pathogen recognition receptor ligands...
  42. pmc Role of granulocyte macrophage colony-stimulating factor in host defense against pulmonary Cryptococcus neoformans infection during murine allergic bronchopulmonary mycosis
    Gwo Hsiao Chen
    Division of Pulmonary and Critical Care Medicine, University of Michigan Medical School, Ann Arbor, MI 48109 0642, USA
    Am J Pathol 170:1028-40. 2007
    ..Production of both Th1 and Th2 cytokines was impaired in the absence of GM-CSF, consistent with both reduced C. neoformans clearance and absence of allergic lung pathology...
  43. ncbi Pulmonary cryptococcosis in nonimmunocompromised patients
    Hassan F Nadrous
    Division of Pulmonary and Critical Care Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Chest 124:2143-7. 2003
    ..However, isolated pulmonary cryptococcosis in nonimmunocompromised hosts has been reported to resolve spontaneously without treatment...
  44. ncbi A dual role for TGF-beta1 in the control and persistence of fungal pneumonia
    Xiuping Shao
    Department of Pediatrics, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    J Immunol 175:6757-63. 2005
    ....
  45. ncbi Efficacy and toxicity of caspofungin in combination with liposomal amphotericin B as primary or salvage treatment of invasive aspergillosis in patients with hematologic malignancies
    Dimitrios P Kontoyiannis
    Department of Infectious Diseases, Infection Control and Employee Health, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer 98:292-9. 2003
    ..Therefore, the authors retrospectively evaluated the efficacy and toxicity of CAS plus liposomal amphotericin B (LipoAMB) in patients with documented (definite or probable) or possible IA...
  46. pmc Persistent Cryptococcus neoformans pulmonary infection in the rat is associated with intracellular parasitism, decreased inducible nitric oxide synthase expression, and altered antibody responsiveness to cryptococcal polysaccharide
    D L Goldman
    Division of Infectious Diseases, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Infect Immun 68:832-8. 2000
    ..neoformans; and (iv) reduced antibody responses to cryptococcal polysaccharide. The results show that maintenance of persistent infection is associated with downregulation of both cellular and humoral immune responses...
  47. pmc Protective role of lung surfactant protein D in a murine model of invasive pulmonary aspergillosis
    T Madan
    Centre for Biochemical Technology, Council for Scientific and Industrial Research, Delhi 110007, India
    Infect Immun 69:2728-31. 2001
    ..Treatment with AmB, SP-D, and rSP-D increased the survival rate to 80, 60, and 80%, respectively, suggesting that SP-D (and rSP-D) can protect immunosuppressed mice from an otherwise fatal challenge with Aspergillus fumigatus conidia...
  48. ncbi An innate immune system cell is a major determinant of species-related susceptibility differences to fungal pneumonia
    Xiuping Shao
    Department of Pediatrics, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    J Immunol 175:3244-51. 2005
    ..In summary, differences in AM function in rats and mice suggest an explanation for the species differences in susceptibility to C. neoformans based on the inherent efficacy of a central effector cell of the innate immune system...
  49. pmc Phagocytic activity and monocyte chemotactic protein expression by pulmonary macrophages in persistent pulmonary cryptococcosis
    Wu He
    Department of Pediatrics, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Infect Immun 71:930-6. 2003
    ..Furthermore, we find that phagocytosis of C. neoformans can serve as an important stimulus for MCP-1 production by PuM, though the efficiency of this process is dependent on the opsonin type and may be affected by aging...
  50. ncbi Pulmonary cryptococcosis in patients without HIV infection
    J A Aberg
    AIDS Clinical Trials Unit, San Francisco General Hospital AIDS Program, University of California 94110, USA
    Chest 115:734-40. 1999
    ..To further elucidate the diagnostic and therapeutic approaches to patients with pulmonary cryptococcosis who are not HIV-infected...
  51. ncbi Clinical evaluation of a polymerase chain reaction assay to detect Aspergillus species in bronchoalveolar lavage samples of neutropenic patients
    Dieter Buchheidt
    III Medizinische Universitätsklinik, Klinikum Mannheim, Mannheim, Germany
    Br J Haematol 116:803-11. 2002
    ..4%, the positive predictive value 83.8%, the negative predictive value 98.1%. Our data support the considerable clinical value of this PCR assay for confirming and improving diagnosis of pulmonary aspergillosis in high-risk patients...
  52. ncbi Aspergillus detection in bronchoscopically acquired material. Significance and interpretation
    H J Seyfarth
    Medizinische Klinik I, Abteilung Pneumologie, , Germany
    Mycoses 44:356-60. 2001
    ..Cultivation of Aspergillus was more successful in BAL, and the Aspergillus antigen detection was more successful in BL...
  53. ncbi Coccidioidomycosis
    Tom M Chiller
    Division of Infectious Diseases, Department of Medicine, Santa Clara Valley Medical Center, 751 South Bascom Avenue, San Jose, CA 95128 2699, USA
    Infect Dis Clin North Am 17:41-57, viii. 2003
    ..Coccidioides, a fungus, is endemic to specific parts of the Western Hemisphere. This article examines the prevalence, pathogenesis and host defense, clinical manifestations, diagnosis, and treatment of coccidioidomycosis...
  54. pmc Inheritance of immune polarization patterns is linked to resistance versus susceptibility to Cryptococcus neoformans in a mouse model
    Gwo Hsiao Chen
    VA Medical Center Ann Arbor, Ann Arbor, MI 48105, USA
    Infect Immun 76:2379-91. 2008
    ..The enhanced pulmonary lymphocyte recruitment could be responsible for a gradual shutdown of the undesirable Th2 arm of the immune response and subsequently improved anticryptococcal resistance in F1 mice...
  55. ncbi Immunoparalysis as a cause for invasive aspergillosis?
    Koen J Hartemink
    Department of Intensive Care, VU University Medical Center, PO Box 7057, 1007 MB, Amsterdam, The Netherlands
    Intensive Care Med 29:2068-71. 2003
    ..Physicians treating critically ill patients in the ICU should be aware of the CARS/immunoparalysis syndrome and its potential to cause opportunistic infections, even in patients with normal immune function prior to ICU admission...
  56. ncbi The value of the chest computed tomography halo sign in the diagnosis of invasive pulmonary aspergillosis. An autopsy-based retrospective study of 48 patients
    M Kami
    Department of Hematology, Toranomon Hospital, Tokyo, Japan
    Mycoses 45:287-94. 2002
    ..For CT findings other than these three signs, there were no significant differences between IPA- and non-IPA patients...
  57. ncbi [A case of allergic bronchopulmonary mycosis caused by Schizophyllum commune]
    Akira Yamasaki
    Third Department of Internal Medicine, Faculty of Medicine, Tottori University
    Arerugi 51:439-42. 2002
  58. ncbi Interleukin-4 causes susceptibility to invasive pulmonary aspergillosis through suppression of protective type I responses
    E Cenci
    Microbiology Section, Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Perugia, Italy
    J Infect Dis 180:1957-68. 1999
    ..fumigatus by inhibition of protective Th1 responses. IL-4 appears to have a distinct role in the pathogenesis of allergic and nonallergic lung diseases caused by the fungus...
  59. ncbi State-of-the-art review of pulmonary fungal infections
    L Joseph Wheat
    Indiana University School of Medicine, Indianapolis Department of Veterans Affairs Hospital, USA
    Semin Respir Infect 17:158-81. 2002
    ..The lung is the portal of entry for most of these pathogens, and often is prominently involved in the clinical syndrome. This article focuses on the recognition, diagnosis, and management of these important pulmonary mycoses...
  60. ncbi Invasive pulmonary aspergillosis: frequency and meaning of the "hypodense sign" on unenhanced CT
    M Horger
    Department of Diagnostic Radiology, Eberhard Karls University, Hoppe Seyler Strasse 3, 72076 Tubingen
    Br J Radiol 78:697-703. 2005
    ..The hypodense sign is recognizable also on unenhanced CT, when a narrower lung window setting is used...
  61. ncbi Pulmonary cryptococcosis: CT and pathologic findings
    Steven E Zinck
    Department of Radiology, University of British Columbia, Vancouver, Canada
    J Comput Assist Tomogr 26:330-4. 2002
    ..The purpose of this work was to describe the CT and pathologic findings of pulmonary cryptococcosis...
  62. ncbi Chronic necrotizing pulmonary aspergillosis in pneumoconiosis: clinical and radiologic findings in 10 patients
    Takashi Kato
    Department of Internal Medicine, Asahi Rosai Hospital, Aichi, Japan
    Chest 121:118-27. 2002
    ..To characterize clinical, radiographic, and CT findings of chronic necrotizing pulmonary aspergillosis (CNPA) in patients with pneumoconiosis...
  63. ncbi Refractory Aspergillus pneumonia in patients with acute leukemia: successful therapy with combination caspofungin and liposomal amphotericin
    Timothy B Aliff
    Leukemia Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Cancer 97:1025-32. 2003
    ..The authors treated a group of patients with amphotericin-refractory IFIs with the combination of caspofungin and amphotericin (or liposomal amphotericin)...
  64. ncbi The radiology of pulmonary cryptococcosis in a tertiary medical center
    J M Lacomis
    Department of Radiology, University of Pittsburgh Medical Center, PA 15213, USA
    J Thorac Imaging 16:139-48. 2001
    ..Chest computed tomography (CT) contributes to a more comprehensive understanding of pulmonary cryptococcal infections...
  65. pmc Semiquantitative detection by real-time PCR of Aspergillus fumigatus in bronchoalveolar lavage fluids and tissue biopsy specimens from patients with invasive aspergillosis
    Kaisu Rantakokko-Jalava
    Department of Medical Microbiology, University of Turku, Finland
    J Clin Microbiol 41:4304-11. 2003
    ..fumigatus. Semiquantitative detection of A. fumigatus mtDNA in BAL fluid may be helpful in the diagnosis of IPA. PCR is well suited for the verification of the presence of A. fumigatus in tissue biopsy specimens...
  66. ncbi Invasive pulmonary aspergillosis in chronic obstructive pulmonary disease: an emerging fungal pathogen
    F Ader
    Service de Réanimation Médicale et Maladies Infectieuses, CH de Tourcoing, Tourcoing, France
    Clin Microbiol Infect 11:427-9. 2005
    ..Survival depends on rapid diagnosis and early appropriate treatment. A decrease or interruption of steroid treatment should be considered as part of the overall therapeutic strategy...
  67. ncbi A large outbreak of histoplasmosis among American travelers associated with a hotel in Acapulco, Mexico, spring 2001
    Juliette Morgan
    Mycotic Diseases Branch, Division of Bacterial and Mycotic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Am J Trop Med Hyg 69:663-9. 2003
    ..7-30.5; P < 0.001). This is the first histoplasmosis outbreak associated with a hotel undergoing construction. Hotels in endemic areas should consider construction precaution measures to prevent histoplasmosis among their guests...
  68. ncbi An outbreak of acute pulmonary histoplasmosis in members of a trekking trip in Martinique, French West Indies
    J Salomon
    Department of Infectious Diseases and Internal Medicine, Raymond Poincare University Hospital, 104 boulevard Raymond Poincaré, 92 380 Garches, France
    J Travel Med 10:87-93. 2003
    ..The 12 others performed canyoning and did not go through the tunnel (control group). Fifteen days after exposure, 1 patient of the tunnel group developed fever, chills, and cough...
  69. ncbi A case of invasive pulmonary aspergillosis in renal failure
    Anders O Sahlén
    Nephrol Dial Transplant 19:2687. 2004
  70. ncbi Coccidioidomycosis: a descriptive survey of a reemerging disease. Clinical characteristics and current controversies
    Nancy F Crum
    Clinical Investigation Department, Infectious Disease Division, Naval Medical Center San Diego, San Diego, California 92134 1005, USA
    Medicine (Baltimore) 83:149-75. 2004
    ..Azole therapy was generally inferior to amphotericin B in disseminated disease. Predictors of permanent disability included African American or Filipino race, central nervous system disease, and bony disease...
  71. ncbi Value of an inhalational model of invasive aspergillosis
    William J Steinbach
    Division of Pediatric Infectious Diseases, Box 3499, Duke University Medical Center, Durham, NC 27710, USA
    Med Mycol 42:417-25. 2004
    ....
  72. pmc Mutation of the WI-1 gene yields an attenuated blastomyces dermatitidis strain that induces host resistance
    M Wuthrich
    Department of Pediatrics, The Comprehensive Cancer Center, University of Wisconsin Medical School, University of Wisconsin Hospital, Madison, USA
    J Clin Invest 106:1381-9. 2000
    ..Thus, by mutating a pathogenetic locus in a dimorphic fungus, we have created an attenuated vaccine strain and have begun to elucidate fungal and host elements requisite for vaccine immunity...
  73. ncbi Triazole-polyene antagonism in experimental invasive pulmonary aspergillosis: in vitro and in vivo correlation
    Joseph Meletiadis
    Immunocompromised Host Section, Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA
    J Infect Dis 194:1008-18. 2006
    ..No pharmacokinetic interaction was found. The combination of a triazole and polyene may be antagonistic in the treatment of invasive pulmonary aspergillosis...
  74. ncbi Paradoxical increase in circulating Aspergillus antigen during treatment with caspofungin in a patient with pulmonary aspergillosis
    Rocus R Klont
    Department of Medical Microbiology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    Clin Infect Dis 43:e23-5. 2006
    ..With the exception of treatment with the echinocandin, no other factors were found that might explain this clinical observation, which was supported by experiments done in vitro...
  75. ncbi [Successful treatment by voliconazole for pulmonary and adductor magnus muscle aspergillosis induced by immunosuppressive therapy for hypersensitivity pneumonia]
    Hidenori Ichiyasu
    Department of Respiratory Medicine, Faculty of Medical and Pharmaceutical Sciences, Kumamoto University
    Nihon Kokyuki Gakkai Zasshi 44:754-60. 2006
    ..Furthermore, the high level of beta-D glucan in serum decreased gradually. This case suggests that administration of VCZ can be recommended for deep seated mycoses...
  76. ncbi Efficacy of micafungin alone or in combination against experimental pulmonary aspergillosis
    Karl V Clemons
    California Institute for Medical Research, San Jose, CA 95128, USA
    Med Mycol 44:69-73. 2006
    ..Overall, these results indicate that MICA has moderate activity against pulmonary aspergillosis and might be useful in combination with conventional AMB...
  77. ncbi Disseminated invasive aspergillosis in a patient with acute leukaemia
    Magnus Gottfredsson
    Department of Medicine, Landspitali University Hospital, Fossvogur, 101 Reykjavik, Iceland
    Acta Biomed 77:10-3. 2006
    ..The patient died one week following the diagnosis of aspergillosis...
  78. pmc Antifungal prophylaxis is effective against murine invasive pulmonary aspergillosis
    Gunter Rieg
    Antimicrob Agents Chemother 50:2895-6. 2006
  79. pmc Characterization and comparison of galactomannan enzyme immunoassay and quantitative real-time PCR assay for detection of Aspergillus fumigatus in bronchoalveolar lavage fluid from experimental invasive pulmonary aspergillosis
    Andrea Francesconi
    Immunocompromised Host Section, Pediatric Oncology Branch, National Cancer Institute, Bldg 10 CRC, Rm 1 5740, Bethesda, MD 20892, USA
    J Clin Microbiol 44:2475-80. 2006
    ..04). Use of the GM EIA and qPCR assay in conjunction with culture-based diagnostic methods applied to BAL fluid could facilitate accurate diagnosis and more-timely initiation of specific therapy...
  80. ncbi Successful major surgical recovery of a patient following haploidentical stem cell transplantation for chronic myeloid leukemia in blast crisis and aspergillosis
    Gabor Varadi
    Department of Bone Marrow Transplantation, Hadassah University Hospital, Jerusalem, Israel
    Acta Haematol 108:29-32. 2002
    ..Most notably, normal and fast recovery was observed following major surgery 7 months post-haplo SCT which is usually considered to result in long-lasting immunosuppression and malfunction of the immune system...
  81. ncbi Radiological resolution of cavitating Aspergillus fumigatus infection following treatment with oral voriconazole in two lung transplant recipients
    Zaid Zoumot
    Transpl Int 19:688-90. 2006
  82. ncbi Multi-azole resistance in Aspergillus fumigatus
    Susan J Howard
    School of Medicine, The University of Manchester, Oxford Road, Manchester M13 9PL, UK
    Int J Antimicrob Agents 28:450-3. 2006
    ..The patient had some response to intravenous caspofungin, which he received six times weekly, without the development of resistance over 9 months...
  83. pmc Efficient clearance of Aspergillus fumigatus in murine lungs by an ultrashort antimicrobial lipopeptide, palmitoyl-lys-ala-DAla-lys
    Alexandra Vallon-Eberhard
    Department of Biological Chemistry, Weizmann Institute of Science, Rehovot 76100, Israel
    Antimicrob Agents Chemother 52:3118-26. 2008
    ..Our results highlight the potential of this family of lipopeptides for the treatment of pulmonary invasive aspergillosis...
  84. ncbi [Clinical cases in medical mycology. Case no. 32]
    Ricardo Negroni
    Unidad de Micologia, Hospital de Infecciosas Francisco Javier Muniz, Uspallata 2272 1282, Buenos Aires, Argentina
    Rev Iberoam Micol 25:65-7. 2008
  85. ncbi [Cutaneous, pulmonary and bone aspergillosis in a patient presumed immunocompetent presenting subacute cutaneous lupus erythematosus]
    V Domergue
    Service de Dermatologie, Hopital Haut Leveque, CHU de Bordeaux, 1, Avenue de Magellan, 33604 Pessac Cedex, France
    Ann Dermatol Venereol 135:217-21. 2008
    ..We report a case of cutaneous, pulmonary and bone aspergillosis successfully treated after many years of progression in a patient presumed immunocompetent presenting subacute cutaneous lupus erythematosus...
  86. pmc Assessment of serum (1->3)-beta-D-glucan concentration as a measure of disease burden in a murine model of invasive pulmonary aspergillosis
    Nathan P Wiederhold
    The University of Texas at Austin College of Pharmacy, Austin, Texas, USA
    Antimicrob Agents Chemother 52:1176-8. 2008
    ..Serum (1-->3)-beta-D-glucan was detected early during the course of infection, and reductions in this biomarker were associated with improved survival in animals treated with antifungal agents...
  87. ncbi [Breakthrough pulmonary mucormycosis during voriconazole treatment after reduced-intensity cord blood transplantation for a patient with acute myeloid leukemia]
    Motohiro Shindo
    Division of Gastroenterology and Hematology Oncology, Department of Medicine, Asahikawa Medical College
    Rinsho Ketsueki 48:412-7. 2007
    ..These findings suggest that it is very important to pay attention to mucormycosis in hematopoietic stem cell transplant recipients in this country...
  88. ncbi [Pulmonary mucormycosis: difficulties in diagnosis and treatment]
    A Pipet
    Service de Pneumologie, Centre Hospitalo Universitaire de Nantes, France
    Rev Mal Respir 24:617-21. 2007
    ..Gastro-intestinal, cutaneous and disseminated disease is less common. The principal risk factors are immuno-suppression and diabetic keto-acidosis...
  89. ncbi Sinopulmonary aspergillosis in children with hematological malignancy
    H Gulen
    Division of Pediatric Hematology, Department of Pediatrics, Celal Bayar University Faculty of Medicine Manisa, Turkey
    Minerva Pediatr 58:319-24. 2006
    ..Early diagnosis, appropriate treatment and primary disease status are important factors on prognosis of Aspergillus infections in children with hematological malignancy...
  90. ncbi Aerosolized nanostructured itraconazole as prophylaxis against invasive pulmonary aspergillosis
    Carlos A Alvarez
    The University of Texas at Austin College of Pharmacy, 1 University Station, A1900, Austin, TX 78712, USA
    J Infect 55:68-74. 2007
    ..We evaluated the effectiveness of an aerosolized nanostructured formulation of itraconazole produced by spray freezing into liquid (SFL) as prophylaxis against invasive pulmonary aspergillosis caused by A. fumigatus...
  91. doi Invasive pulmonary aspergillosis associated with marijuana use in a man with colorectal cancer
    David W Cescon
    Department of Medicine, University of Toronto, Toronto, Canada
    J Clin Oncol 26:2214-5. 2008
  92. pmc Assessment of Aspergillus fumigatus burden in pulmonary tissue of guinea pigs by quantitative PCR, galactomannan enzyme immunoassay, and quantitative culture
    Ana C Vallor
    The University of Texas Health Science Center at San Antonio, Department of Medicine, Division of Infectious Diseases, 7703 Floyd Curl Drive, Mail Code 7881, San Antonio, TX 78229 3900, USA
    Antimicrob Agents Chemother 52:2593-8. 2008
    ..02). Confirmation of fungal tissue burden by two or more methods should provide a more precise account of the burden, allowing improved assessment of diagnostic and therapeutic strategies in invasive pulmonary aspergillosis...
  93. ncbi Efficacy of intravenous itraconazole against invasive pulmonary aspergillosis in neutropenic mice
    Shigeru Tansho
    Department of Microbiology and Immunology, University of Teikyo, School of Medicine, 2 11 1 Kaga, Itabashi ku, Tokyo 173 8605, Japan
    J Infect Chemother 12:355-62. 2006
    ..fumigatus (0.16 microg/ml). These results support the clinical usefulness of ITZ-IV for the treatment of IPA in immunocompromised patients...
  94. ncbi Double invasive fungal infection and typhlitis in children with acute lymphoblastic leukemia
    Zekai Avci
    Department of Pediatric Hematology, Baskent University Faculty of Medicine, Ankara, Turkey
    Pediatr Hematol Oncol 25:99-106. 2008
    ..They were treated with liposomal amphotericin B, but one of them died due to massive pulmonary hemorrhage during recovery from neutropenia...
  95. ncbi Pathogenesis of Aspergillus fumigatus and the kinetics of galactomannan in an in vitro model of early invasive pulmonary aspergillosis: implications for antifungal therapy
    William W Hope
    Immunocompromised Host Section, Pediatric Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Infect Dis 195:455-66. 2007
    ..Little is known about the pathogenesis of invasive pulmonary aspergillosis and the relationship between the kinetics of diagnostic markers and the outcome of antifungal therapy...
  96. ncbi Imaging findings in acute invasive pulmonary aspergillosis: clinical significance of the halo sign
    Reginald E Greene
    Massachusetts General Hospital, Boston, MA 02114, USA
    Clin Infect Dis 44:373-9. 2007
    ....
  97. pmc Caspofungin prolongs survival of transiently neutropenic rats with advanced-stage invasive pulmonary aspergillosis
    Wendy W J van de Sande
    Erasmus MC, University Medical Center Rotterdam, Department of Medical Microbiology and Infectious Diseases, s Gravendijkwal 230, 3015 CE, Rotterdam, The Netherlands
    Antimicrob Agents Chemother 52:1345-50. 2008
    ..In this model, the administration of high-dose-step-down treatment was as effective as treatment with high doses for the whole treatment period...
  98. pmc Itraconazole preexposure attenuates the efficacy of subsequent amphotericin B therapy in a murine model of acute invasive pulmonary aspergillosis
    Russell E Lewis
    Department of Infectious Diseases, Infection Control, and Employee Health, The University of Texas M D Anderson Cancer Center, Houston 77030, USA
    Antimicrob Agents Chemother 46:3208-14. 2002
    ..03). Higher doses of AMB did not overcome this antagonism. ITC preexposure was associated with poorer mycological efficacy and survival in mice treated subsequently with AMB for invasive pulmonary aspergillosis...
  99. ncbi [Dystrophic calcification in the brain after successful treatment of invasive aspergillosis]
    A Camacho-Salas
    Sección de Neurorradiología, Hospital Universitario Doce de Octubre, Madrid, Spain
    Rev Neurol 39:492-3. 2004
  100. ncbi Pharmacodynamics of caspofungin in a murine model of invasive pulmonary aspergillosis: evidence of concentration-dependent activity
    Nathan P Wiederhold
    The University of Houston College of Pharmacy and The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    J Infect Dis 190:1464-71. 2004
    ..We conducted a dosage-fractionation study to characterize the in vivo pharmacodynamics of CAS activity during IPA, using immunosuppressed mice inoculated intranasally with Aspergillus fumigatus...
  101. ncbi Efficacy of voriconazole plus amphotericin B or micafungin in a guinea-pig model of invasive pulmonary aspergillosis
    P H Chandrasekar
    Division of Infectious Diseases, Department of Internal Medicine, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Clin Microbiol Infect 10:925-8. 2004
    ..Further studies of efficacy, dosing and optimal regimens for antifungal combinations are warranted...

Research Grants43

  1. Regional Variation of FDG-PET Scans to diagnose lung cancer
    Eric L Grogan; Fiscal Year: 2013
    ..Retrospective single institution studies have demonstrated that infectious fungal lung diseases, such as histoplasmosis, reduce the specificity FDG- PET scans to diagnose lung cancer...
  2. Monoclonal antibodies for invasive aspergillosis
    Marta Feldmesser; Fiscal Year: 2003
    ..To determine the biological activity of MAbs generated in Aim 2 in murine models of invasive aspergillosis. It is anticipated that this study will identify important targets for further investigation. ..
  3. Aspergillosis: Engineering Antibody for Diagnosis
    Marta Feldmesser; Fiscal Year: 2006
    ..The availability of reagents that have potential to improve both sensitivity and specificity of galactomannan detection would be a significant advance. ..
  4. PROTECTIVE ANTIGENS FROM HISTOPLASMA CAPSULATUM
    GEORGE DEEPE; Fiscal Year: 2007
    ..abstract_text> ..
  5. Defending Against Systemic Mycoses
    GEORGE DEEPE; Fiscal Year: 2008
    ..The collaborative and synergistic effort manifested by this group of investigators will provide new and exciting information regarding prevention and/or treatment of these problematic fungi. ..
  6. Monoclonal antibodies to inhibit Aspergillus germination
    MARTA L FELDMESSER; Fiscal Year: 2010
    ..It is anticipated that this study will identify fungal molecules important for germination and begin to define their interaction with host immune responses. ..
  7. MODULATION OF TH1/TH2 RESPONSES BY INNATE IMMUNITY
    GARY HUFFNAGLE; Fiscal Year: 2004
    ..One of the potential implications of these studies is that therapies inhibiting melanin biosynthesis or activity may also have an adjuvant effect and promote the development of protective Th1 immunity to C. neoformans. ..
  8. Role of Oxylipins in Cryptococcal Pathogenesis
    GARY HUFFNAGLE; Fiscal Year: 2008
    ..production; (3) to determine the role of the fungal oxylipin CnPGEx in cryptococcal biology and pathogenesis; (4) to determine the role of host PGE2 and other prostaglandins in cryptococcal biology and host immunity ..
  9. Detection and Significance of Antifungal Resistance in Oropharyngeal Candidiasis
    Thomas F Patterson; Fiscal Year: 2010
    ..This research is aimed at developing rapid molecular tests to detect yeasts which are resistant to antifungal agents in order to allow early use of more effective therapy. ..
  10. Genetic Determinants of A. Fumigatus Susceptibility
    Aimee Zaas; Fiscal Year: 2008
    ..fumigatus infection, this proposal will identify and characterize genetic polymorphisms related to IA susceptibility in mice and validate these findings in a cohort of human bone marrow transplant donors and recipients. ..
  11. Role of Fungal Microflora in Mucosal Tolerance/Immunity
    GARY HUFFNAGLE; Fiscal Year: 2009
    ..These studies will provide the basic science foundation for future studies in humans for understanding how and why manipulation of the microflora (by diet or probiotics) can alter or prevent allergies. ..
  12. Molecular Epidemiology of Human P. carinii Pneumonia
    Laurence Huang; Fiscal Year: 2006
    ..abstract_text> ..
  13. CHEMOKINE RECEPTORS IN IMMUNITY TO C NEOFORMANS
    GARY HUFFNAGLE; Fiscal Year: 2003
    ..neoformans infection; (5) To determine the role of MCP-1 and CCR2 in the development of a Th2 response to C. neoformans. ..
  14. C. Neoformans Infection in Organ Transplant Recipients
    Nina Singh; Fiscal Year: 2005
    ..Finally, the data regarding reactivation or primary infection has implications relevant for the prevention of C. neoformans infection in transplant recipients. ..
  15. Re-Engineering the Clinical Research Enterprise
    Carol Hamilton; Fiscal Year: 2004
    ..Create an interoperable, secure web-based electronic data capture system for the TBTC, that will interface with public health surveillance systems...
  16. ADULT AIDS CLINICAL TRIALS UNIT
    Mitchell Goldman; Fiscal Year: 2008
    ..Specialized immunology, virology, and pharmacology laboratories will support this work. ..
  17. Calcineurin and Aspergillus fumigatus Pathogenesis
    WILLIAM STEINBACH; Fiscal Year: 2008
    ..I will also test the non-immunosuppressive calcineurin inhibitor analogs to decrease the total level of immunosuppression and therefore increase the overall antifungal efficacy of exploiting the calcineurin pathway. ..
  18. The Molecular Microbiology of Bacterial Vaginosis
    David Fredricks; Fiscal Year: 2003
    ..In future studies, vaginal fluid samples from a larger cohort of women will be assayed to determine if a candidate pathogen is specifically associated with BV. ..
  19. MOLECULAR BASIS OF PHENOTYPIC SWITCHING IN 24067 MUTANT
    Bettina Fries; Fiscal Year: 2003
    ..The second part is designed to clone the gene mediating this complex phenotype and the third part will aim to establish whether there is a causative relationship between chromosomal rearrangement and switching. ..
  20. THE ROLE OF UROKINASE IN LUNG T LYMPHOCYTE RESPONSES
    MARGARET GYETKO; Fiscal Year: 2003
    ..Determine if recombinant uPA can reverse the functional abnormalities in uPA minus/minus lymphocytes. ..
  21. IL-13 Fusion Cytotoxin as a Targeted Therapeutic for IIP
    Cory Hogaboam; Fiscal Year: 2006
    ..The proposed studies will critically evaluate a pathophysiologic paradigm in IIP that has not been thoroughly examined to date. ..
  22. ABCA3 and Alveolar Homeostasis
    Jeffrey A Whitsett; Fiscal Year: 2010
    ....
  23. Transcriptional Control of Respiratory Epithelial Progenitor Cells
    Jeffrey A Whitsett; Fiscal Year: 2010
    ..A Stem Cell Consortium will be established at CCHMC, Univ. of Cincinnati College of Medicine to develop education, training, and research bridging hematopoietic stem cell and pulmonary stem cell biology on our campus. ..
  24. TB Clinical Research: Training the Next Generation
    Carol Hamilton; Fiscal Year: 2008
    ..Her work with the Duke Center for Human Genetics is an example of translational research she hopes to foster within her mycobacteria research program. ..
  25. Quantitative PCR for the Detection of Fungal Infections
    David Fredricks; Fiscal Year: 2008
    ..Hypothesis: Fungal 18S rDNA qPCR employing a broad range fungal probe, or a system of multiple specific probes, will be useful for detecting emerging fungal pathogens in the transplant setting. [unreadable] [unreadable]..
  26. LUNG PRESERVATION FOR TRANSPLANTATION
    G Patterson; Fiscal Year: 2006
    ..The first aim of this project is to examine the role of NF-KappaB activation in I/R injury. The second aim of this project is to investigate the mechanisms by which gene transfer of IL-10 ameliorates I/R injury. ..
  27. SHH and Alveolar Formation
    Jeffrey Whitsett; Fiscal Year: 2006
    ..abstract_text> ..
  28. Therapeutic Targeting of RANTES/CCL5 in Fungal Asthma.
    Cory Hogaboam; Fiscal Year: 2006
    ..These detailed studies are now possible because of the availability of novel chimeric protein that selectively targets RANTES/CCL5-responsive cells in the lung. ..
  29. Diaphragmatic Transplantation for Muscular Dystrophy
    G Patterson; Fiscal Year: 2006
    ....
  30. HYDROXYCHLOROQUINE THERAPY AND BIOLOGY OF GVHD
    Andrew Gilman; Fiscal Year: 2004
    ..Blood from patients will be examined at study entry and then every three months to examine the biology of chronic GVHD, and to see if the different treatment regimens affect the immune system differently. ..
  31. PERINATAL EXPRESSION OF SURFACTANT PROTEIN GENE SP-B
    Jeffrey Whitsett; Fiscal Year: 2007
    ..Transcriptional responses to decreased SP-B will be determined using RNA microarray, to identify the molecular pathways mediating or compensating for reduced SP-B/surfactant function in vivo. [unreadable] [unreadable]..
  32. Imaging of Pulmonary Cancer: Overcoming Limitations
    Jane Ko; Fiscal Year: 2007
    ..The proposed method will enable early recognition of nodule growth and, therefore, the early diagnosis of malignancy. ..
  33. Cholesterol and Sphingolipid Perturbation of Membrane Traffic in Human Disease
    Andrew H Limper; Fiscal Year: 2011
    ..The following studies will examine the role of these lipids in exacerbating the symptoms of Cystic fibrosis and will be used in developing new therapeutic approaches for this disease. ..
  34. Genital Ulcer Disease and HIV Transmission
    Jeanne Sheffield; Fiscal Year: 2005
    ..The pursuit of these aims will further elucidate the cellular and molecular bases of the interrelationship between GUD and HIV-1 transmission, particularly in women. ..
  35. Genetic epidemiology of TLR4 alleles and bacteremia
    Jason Chien; Fiscal Year: 2006
    ..Ultimately, this cohort of patients will be developed in anticipation of future genetic discoveries in the complicated pathway of pathogen recognition and host inflammatory response. ..
  36. Control of the Pneumocystis carinii Life Cycle
    Andrew Limper; Fiscal Year: 2008
    ..abstract_text> ..
  37. Clinical Suspicion of TB: A Technology Assessment Tool
    Antonino Catanzaro; Fiscal Year: 2007
    ..It will help define the role of serologic testing in the diagnosis of PTB. ..
  38. NHLBI Respiration Biology Research Training Grant
    Andrew Limper; Fiscal Year: 2007
    ..Candidate are committed to a minimum of two, but preferably three or more years of full time research. A wide range of didactic courses is available to complement the intensive laboratory experience. ..
  39. Pulmonary CD4+ T-Cell Repopulation in Immune Reconstituion Syndrome
    Kenneth Knox; Fiscal Year: 2009
    ..Patients who are at risk for these therapy-related problems need to know if their long term health is affected. ..
  40. PHOSPHOLIPASE B: A VIRULENCE FACTOR FOR CANDIDA GLABRATA
    CORNELIUS CLANCY; Fiscal Year: 2002
    ....
  41. Oral and Vaginal Gene Expression by Candida During AIDS
    CORNELIUS CLANCY; Fiscal Year: 2004
    ..abstract_text> ..