Genomes and Genes
Summary: A subcategory of CHRONIC OBSTRUCTIVE PULMONARY DISEASE. The disease is characterized by hypersecretion of mucus accompanied by a chronic (more than 3 months in 2 consecutive years) productive cough. Infectious agents are a major cause of chronic bronchitis.
Publications255 found, 100 shown here
- [Effect of Eucalyptus globulus oil on lipopolysaccharide-induced chronic bronchitis and mucin hypersecretion in rats]Xiao qin Lu
Zhejiang Respiratory Drugs Research Laboratory of State Food and Drugs Administration of China, College of Medical Sciences, Zhejiang University, Hangzhou 310031, China
Zhongguo Zhong Yao Za Zhi 29:168-71. 2004To study the effect of Eucalyptus globulus oil on bronchiolitis and mucin hypersecretion in chronic bronchitis induced by lipopolysaccharide in rats.
- COPD and chronic bronchitis risk of indoor air pollution from solid fuel: a systematic review and meta-analysisOm P Kurmi
Institute of Occupational and Environmental Medicine, School of Population and Health Sciences, University of Birmingham, Birmingham B15 2TT, UK
Thorax 65:221-8. 2010..The aim of this systematic review was to quantify the impact of biomass smoke on the development of COPD and define reasons for differences in the reported effect sizes...
- Chronic bronchitis before age 50 years predicts incident airflow limitation and mortality riskS Guerra
Arizona Respiratory Center, University of Arizona, Tucson, AZ 85724 5030, USA
Thorax 64:894-900. 2009Previous studies on the relationship of chronic bronchitis to incident airflow limitation and all-cause mortality have provided conflicting results, with positive findings reported mainly by studies that included populations of young ..
- Development of chronic bronchitis and emphysema in beta-epithelial Na+ channel-overexpressing miceMarcus A Mall
Pediatric Pulmonology and Cystic Fibrosis Center, Department of Pediatrics III, University of Heidelberg, Im Neuenheimer Feld 153, 69120 Heidelberg, Germany
Am J Respir Crit Care Med 177:730-42. 2008..Previous studies have shown that airway surface dehydration in beta-epithelial Na(+) channel (betaENaC)-overexpressing mice caused a chronic lung disease with high neonatal pulmonary mortality and chronic bronchitis in adult survivors.
- Resolution of bronchial inflammation is related to bacterial eradication following treatment of exacerbations of chronic bronchitisA J White
Department of Respiratory Medicine, Queen Elizabeth Hospital, Birmingham B15 2TH, UK
Thorax 58:680-5. 2003Recent studies of the role of bacteria in chronic bronchitis have shown that bacterial colonisation is associated with enhanced inflammation and that purulent acute exacerbations of chronic bronchitis (AECB) are associated with bacteria ..
- Acute exacerbations of chronic bronchitis in elderly patients: pathogenesis, diagnosis and managementDon Hayes
Department of Pediatrics, University of Kentucky College of Medicine, Lexington, Kentucky, USA
Drugs Aging 24:555-72. 2007b>Chronic bronchitis (CB) is a disorder that is characterised by chronic mucus production. This disorder is called chronic obstructive pulmonary disease (COPD) when airflow obstruction is present...
- Predictors of chronic bronchitis in South African adultsR I Ehrlich
School of Public Health and Family Medicine, University of Cape Town, Cape Town, South Africa
Int J Tuberc Lung Dis 8:369-76. 2004..National household survey of adults in South Africa, a middle income country...
- Variation of CD8+ T-lymphocytes around the bronchial internal perimeter in chronic bronchitisE Gamble
Lung Pathology, Dept of Gene Therapy, Imperial College London at the Royal Brompton Hospital, London, UK
Eur Respir J 22:992-5. 2003..of CD8+ cells has been determined around the internal perimeter of intrapulmonary bronchi in smokers with chronic bronchitis (CB), and the amount of tissue required to confidently estimate the true mean has been calculated...
- Upregulation of basic fibroblast growth factor in smokers with chronic bronchitisF Guddo
Pathology Unit, V Cervello Hospital, Palermo, Italy
Eur Respir J 27:957-63. 2006..bFGF) and its receptor, fibroblast growth factor receptor (FGFR)-1, in the central airways of smokers with chronic bronchitis. The lobar bronchi from 17 subjects undergoing thoracotomy for solitary nodules were examined...
- Interaction between smoking and genetic factors in the development of chronic bronchitisJenny Hallberg
Department of Occupational and Environmental Health, Norrbacka, Karolinska Hospital, SE 171 76 Stockholm, Sweden
Am J Respir Crit Care Med 177:486-90. 2008Smoking is a primary risk factor for chronic bronchitis, emphysema, and chronic obstructive pulmonary disease, but since not all smokers develop disease, it has been suggested that some individuals may be more susceptible to exogenous ..
- Animal models of chronic bronchitis and their relevance to studies of particle-induced diseaseK J Nikula
Lovelace Respiratory Research Institute, Albuquerque, New Mexico, USA
Inhal Toxicol 12:123-53. 2000b>Chronic bronchitis is a significant cause of morbidity and mortality...
- Responsiveness of the cough and sputum assessment questionnaire in exacerbations of COPD and chronic bronchitisBrigitta U Monz
Boehringer Ingelheim GmbH, Binger Strasse 173, D 55216 Ingelheim, Germany
Respir Med 104:534-41. 2010To assess the responsiveness of the Cough and Sputum Assessment Questionnaire (CASA-Q) in COPD and chronic bronchitis patients recovering from an acute exacerbation...
- Double-blind study of OM-85 in patients with chronic bronchitis or mild chronic obstructive pulmonary diseaseM Soler
Pneumologie, St Claraspital, Basel, Switzerland
Respiration 74:26-32. 2007..OM-85, a detoxified immunoactive bacterial extract, has been shown to prevent recurrent exacerbations of bronchitis and COPD...
- CTLA4 gene polymorphisms are associated with chronic bronchitisG Zhu
Glaxo SmithKline R and D, Research Triangle Park, NC 27709, USA
Eur Respir J 34:598-604. 2009..T-lymphocytes may play a key role in the pathogenesis of COPD and chronic bronchitis. Cytotoxic T-lymphocyte antigen (CTLA) 4 is a potential candidate gene because it modulates T-cell ..
- Direct medical costs of chronic obstructive pulmonary disease: chronic bronchitis and emphysemaL Wilson
Department of Clinical Pharmacy, School of Pharmacy, University of California, San Francisco 94143 0622, USA
Respir Med 94:204-13. 2000..we aimed to estimate direct medical costs of Chronic Obstructive Pulmonary Disease (COPD) by disease type; chronic bronchitis and emphysema...
- Interleukin-13 and -4 expression in the central airways of smokers with chronic bronchitisD Miotto
Dept of Clinical and Experimental Medicine, University of Ferrara, Ferrara, Italy
Eur Respir J 22:602-8. 2003..T-helper 2-type cytokines interleukin (IL)-13 and -4 are involved in mucus hypersecretion, the hallmark of chronic bronchitis (CB)...
- Plasma cells and IL-4 in chronic bronchitis and chronic obstructive pulmonary diseaseJie Zhu
Lung Pathology Unit, Department of Gene Therapy, Imperial College London at the Royal Brompton Hospital, Sydney St, London SW3 6NP, UK
Am J Respir Crit Care Med 175:1125-33. 2007..Airway wall inflammation, IL-4, and mucus hypersecretion are thought to be associated...
- Chlamydia pneumoniae and chronic bronchitis: association with severity and bacterial clearance following treatmentF Blasi
Institute of Respiratory Diseases, University of Milan, IRCCS Ospedale Maggiore di Milano, Milan, Italy
Thorax 57:672-6. 2002..pneumoniae chronic infection, other respiratory infections, and functional impairment in patients with chronic bronchitis (stage 1) and to examine chronic C pneumoniae infection, rate of acute exacerbations of chronic bronchitis, ..
- The diagnosis and treatment of elderly patients with acute exacerbation of chronic obstructive pulmonary disease and chronic bronchitisTimothy E Albertson
Division of Pulmonary, Critical Care and Sleep Medicine, School of Medicine University of California at Davis, Sacramento, California, USA
J Am Geriatr Soc 58:570-9. 2010The syndrome of chronic obstructive pulmonary disease (COPD) consists of chronic bronchitis (CB), bronchiectasis, emphysema, and reversible airway disease that combine uniquely in an individual patient...
- Moxifloxacin in the management of exacerbations of chronic bronchitis and COPDMarc Miravitlles
Servei de Pneumologia, Institut Clínic del Tòrax IDIBAPS, Hospital Clinic, Barcelona, Spain
Int J Chron Obstruct Pulmon Dis 2:191-204. 2007Bacteria are isolated in more than 50% of exacerbations of chronic bronchitis (CB) and chronic obstructive pulmonary disease (COPD)...
- The role of Bordetella infections in patients with acute exacerbation of chronic bronchitisJ Bonhoeffer
University Children s Hospital Basel, P O Box, CH 4005 Basel, Switzerland
Infection 33:13-7. 2005Acute exacerbations of chronic bronchitis (AECB) are associated with a variety of viral and bacterial infectious agents, some of which are potentially preventable by immunization...
- Vasoactive intestinal peptide receptors in the airways of smokers with chronic bronchitisD Miotto
Dipartimento diMedicina Clinica e Sperimentale, Sezione di Igiene e Medicina del Lavoro, Via Fossato di Mortara 64 b, 44100 Ferrara, Italy
Eur Respir J 24:958-63. 2004..this study was to quantify the expression of both VPAC1R and VPAC2R in the central airways of smokers with chronic bronchitis. Surgical specimens were obtained from 33 smokers undergoing thoracotomy for localised pulmonary lesions: 23 ..
- Atopic diseases, allergic sensitization, and exposure to traffic-related air pollution in childrenVerena Morgenstern
Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Institute of Epidemiology, Ingolstaedter Landstrasse 1, D 85764 Neuherberg, Germany
Am J Respir Crit Care Med 177:1331-7. 2008..In vitro studies, animal experiments, and human exposure studies have shown how ambient air pollution increases the risk of atopic diseases. However, results derived from observational studies are inconsistent...
- Management of chronic obstructive pulmonary disease associated with chronic bronchitis with inhaled fluticasone propionate/salmeterol (ADVAIR DISKUS) 250/50: results of a patient experience trialStuart Stoloff
The University of Nevada School of Medicine, Reno, Nevada, USA
MedGenMed 8:86. 2006..Chronic obstructive pulmonary disease (COPD) is recognized as a major healthcare problem in the United States and around the world...
- Lung function decline, chronic bronchitis, and occupational exposures in young adultsJordi Sunyer
Respiratory and Health Research Unit, Medical Research Institute, Barcelona, Spain
Am J Respir Crit Care Med 172:1139-45. 2005..Occupational exposures to vapors, gas, dust, or fumes have been shown to be a risk factor of airway obstruction in cross-sectional studies in the general population...
- Characterisation of exacerbations of chronic bronchitis and COPD in Europe: the GIANT studyMarc Miravitlles
Servei de Pneumologia Institut Clínic del Tòrax Hospital Clínic, Barcelona, Spain
Ther Adv Respir Dis 3:267-77. 2009The GIANT study collected information on patients with acute exacerbations of chronic bronchitis (AECB) and chronic obstructive pulmonary disease (COPD) and the effect of treatment with moxifloxacin.
- Chronic cough due to chronic bronchitis: ACCP evidence-based clinical practice guidelinesSidney S Braman
Division of Pulmonary and Critical Care Medicine, Rhode Island Hospital, 595 Eddy St, Providence, RI 02903, USA
Chest 129:104S-115S. 2006b>Chronic bronchitis is a disease of the bronchi that is manifested by cough and sputum expectoration occurring on most days for at least 3 months of the year and for at least 2 consecutive years when other respiratory or cardiac causes for ..
- Association of symptoms of chronic bronchitis and frequent flu-like illnesses with strokeArmin J Grau
Department of Neurology, Klinikum der Stadt Ludwigshafen a Rh, Germany
Stroke 40:3206-10. 2009Acute and several chronic infectious diseases increase the risk of stroke. We tested the hypothesis that chronic bronchitis and frequent flu-like illnesses are independently associated with the risk of stroke or transient ischemic attack (..
- Chronic bronchitis and pesticide exposure: a case-control study in LebanonPascale R Salameh
Faculty of Public Health, Lebanese University, Beirut, Lebanon
Eur J Epidemiol 21:681-8. 2006Pesticides are widely used toxics. The objective of the study is to evaluate the odds of exposure to pesticides in chronic bronchitis patients.
- Association of snoring with chronic bronchitisInkyung Baik
Institute of Human Genomic Study, Korea University Ansan Hospital, 516 Gojandong Danwongu, Ansan 425 707, Korea
Arch Intern Med 168:167-73. 2008Snoring is more prevalent in patients with chronic bronchitis than in persons without it. Few studies have examined the effect of snoring on chronic bronchitis...
- Chronic bronchitis in women using solid biomass fuel in rural Peshawar, PakistanTasleem Akhtar
Pakistan Medical Research Council Research Center at Khyber Medical College, Peshawar NWFP 25000, Pakistan
Chest 132:1472-5. 2007Biomass smoke has been associated with many diseases. The aim of this study was to evaluate the relationship between biomass smoke and chronic bronchitis in women in the rural setting of Peshawar, Pakistan.
- Should patients with acute exacerbation of chronic bronchitis be treated with antibiotics? Advantages of the use of fluoroquinolonesJ Mensa
Infectious Diseases Unit, Hospital Clinic, University of Barcelona, Barcelona, Spain
Clin Microbiol Infect 12:42-54. 2006The pathological changes in chronic bronchitis (CB) produce airflow obstruction, reduce the effectiveness of the mucocilliary drainage system and lead to bacterial colonisation of bronchial secretion...
- The workplace impact of acute exacerbations of chronic bronchitis (AECB); A literature reviewMichael T Halpern
Exponent, Inc, Alexandria, Virginia, USA
COPD 1:249-54. 2004Acute exacerbations of chronic bronchitis (AECB) are known to have a substantial economic burden in terms of medical care costs...
- Macrolide immunomodulatory effects and symptom resolution in acute exacerbation of chronic bronchitis and acute maxillary sinusitis: a focus on clarithromycinWilliam R Bishai
The Johns Hopkins University School of Medicine, Division of Infectious Diseases, Department of Medicine, 1550 Orleans Street, CRB2 108, Baltimore, MD 21231, USA
Expert Rev Anti Infect Ther 4:405-16. 2006..Macrolides have proven to be highly effective in treating acute bacterial exacerbations of chronic bronchitis and acute maxillary sinusitis...
- Indicators of bacterial infection in patients with acute exacerbation of chronic bronchitis for application in clinical trials of antibacterial drugsC J Burley
Postgraduate Medical School, Manor Park, University of Surrey, Guildford, UK
J Infect 55:226-32. 2007..WBCs and <10 epithelial cells) and (c) microscopic examination of morphological bacterial cell types, in identifying bacterial infection in patients with an acute exacerbation of chronic bronchitis (AECB) for entry to clinical trials.
- Short-course therapy of acute bacterial exacerbation of chronic bronchitis: a double-blind, randomized, multicenter comparison of extended-release versus immediate-release clarithromycinPiotr Nalepa
Curr Med Res Opin 19:411-20. 2003The objective of this study was to compare the efficacy and safety of two clarithromycin formulations given for 5 days to patients with acute bacterial exacerbation of chronic bronchitis (ABECB).
- Role of oral extended-spectrum cephems in the treatment of acute exacerbation of chronic bronchitisAntonio Anzueto
University of Texas Health Science Center, South Texas Veterans Healthcare System, San Antonio, TX 78284, USA
Diagn Microbiol Infect Dis 57:31S-38S. 2007Risk stratification is the recommended approach for treatment of acute exacerbation of chronic bronchitis (AECB) to optimize the chances of clinical success...
- Acute exacerbation of chronic bronchitis: need for an evidence-based approachClaudio F Donner
Division of Pulmonary Disease, Fondazione Salvatore Maugeri IRCCS, Scientific Institute of Veruno, Veruno NO, Italy
Pulm Pharmacol Ther 19:4-10. 2006Acute exacerbations of chronic bronchitis (AECB) can be classified into three levels according to severity: (1) home treatment sufficient; (2) hospitalisation required; (3) hospitalisation in the presence of respiratory failure...
- FAB-MS characterization of sialyl Lewis x determinants on polylactosamine chains of human airway mucins secreted by patients suffering from cystic fibrosis or chronic bronchitisW Morelle
Department of Biological Sciences, Imperial College of Science, Technology and Medicine, London, SW7 2AY, UK
Glycoconj J 18:699-708. 2001Although a large body of structural data exists for bronchial mucins from cystic fibrosis (CF) and chronic bronchitis (CB) patients, little is known about terminal structures carried on poly-N-acetyllactosamine antennae...
- Open-label, randomized comparison of the efficacy and tolerability of clarithromycin, levofloxacin, and cefuroxime axetil in the treatment of adults with acute bacterial exacerbations of chronic bronchitisLee R Weiss
Department of Emergency Medicine, Knox Community Hospital, Mount Vernon, Ohio 43050, USA
Clin Ther 24:1414-25. 2002..the absence of a confirmed pathogen, empiric antimicrobial treatment of patients with acute exacerbations of chronic bronchitis and acute bacterial exacerbations of chronic bronchitis (ABECB) is accepted as standard practice and ..
- [An experimental study on airway inflammation and remodeling in a rat model of chronic bronchitis and emphysema]Xiao Ning Zhong
Department of Respiratory Diseases, First Affiliated Hospital of Guangxi Medical University, Nanning 530021, China
Zhonghua Jie He He Hu Xi Za Zhi 26:750-5. 2003To study the pathological features of airway inflammation and remodeling in rats with chronic bronchitis (CB) and emphysema and to evaluate the protective and therapeutic effects of erythromycin (EM).
- Anti-oxidative effect of triterpene acids of Eriobotrya japonica (Thunb.) Lindl. leaf in chronic bronchitis ratsYan Huang
School of Pharmacy, Anhui Medical University, Hefei, Anhui Province, China 230032
Life Sci 78:2749-57. 2006..Lindl. leaf (TAL) on expression of antioxidative mediators by alveolar macrophages (AM) in rats with chronic bronchitis (CB), CB was induced by endotracheal instillation of lipopolysaccharedes (LPS) followed by Bacillus Calmette-..
- Chronic exposure to volcanic environments and chronic bronchitis incidence in the Azores, PortugalAndré Filipe Santos Amaral
Department of Biology, University of the Azores, R Mae de Deus, APT 1422, 9501 855 Ponta Delgada, Portugal
Environ Res 103:419-23. 2007..to investigate the existence of a possible association between chronic exposure to volcanic sulfur gases and chronic bronchitis. To investigate this, we used two populations, one exposed to active manifestations of volcanism (Furnas) ..
- Canadian guidelines for the management of acute exacerbations of chronic bronchitisMeyer S Balter
University of Toronto, Mount Sinai Hospital, Toronto, Canada
Can Respir J 10:3B-32B. 2003Acute exacerbations of chronic bronchitis (AECB) account for over 1.5 million physician visits annually in Canada and are a cause of significant morbidity and mortality...
- Development of a quantifiable symptom assessment tool for patients with chronic bronchitis: the Chronic Bronchitis Symptoms Assessment ScaleDavid H Au
Health Services Research and Development, VA Puget Sound Health Care System, 1660 S Columbian Way, Seattle, Washington 98108, USA
COPD 2:209-16. 2005..an instrument to reliably assess symptom severity and frequency in therapeutic trials for patients with chronic bronchitis. We performed a series of psychometric studies that determined instrument content and assessed validity and ..
- Solutions for difficult diagnostic cases of acute exacerbations of chronic bronchitisK W Tsang
Division of Respiratory and Critical Care Medicine, Department of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong, China
Chemotherapy 47:28-38; discussion 53-4. 2001Acute exacerbation of chronic bronchitis (AECB) is a very common condition, which presents with deteriorating sputum production and dyspnoea in a patient with pre-existing COPD or chronic bronchitis...
- [Effect of occupational exposure and smoking on spirometric tests and symptoms of chronic bronchitis]Tomasz Kachel
Oddziału Pulmonologiczno Alergologicznego Specjalistycznego Zespołu, Chorób Płuc i Gruźlicy w Bystrej Saskiej
Pneumonol Alergol Pol 71:428-39. 2003..2 years. In all cases concentrations of noxious agents did not exceed allowed levels. The symptoms of chronic bronchitis (cough and phlegm) were present in 12.3% and airflow limitation (FEV1% FVC < 0.7) in 6.9% of subjects...
- Healthy worker effect in cohort studies on chronic bronchitisKatja Radon
Department of Medicine, Joint Departments of Epidemiology and Biostatistics and Occupational Health, McGill University, Montreal, Quebec, Canada
Scand J Work Environ Health 28:328-32. 2002..The aim of the present paper was to estimate the magnitude of the healthy worker survivor effect in cohort studies of symptoms of chronic bronchitis.
- Macrolides, quinolones and amoxicillin/clavulanate for chronic bronchitis: a meta-analysisI I Siempos
Alfa Institute of Biomedical Sciences AIBS, 9 Neapoleos Street, 151 23 Marousi, Athens, Greece
Eur Respir J 29:1127-37. 2007..and amoxicillin/clavulanate (A/C) for the treatment of patients with acute bacterial exacerbation of chronic bronchitis (ABECB) was evaluated in the present study...
- Gemifloxacin use in the treatment of acute bacterial exacerbation of chronic bronchitisCristian Jivcu
Department of Internal Medicine, Banner Good Samaritan Medical Center, Phoenix, AZ, USA
Int J Chron Obstruct Pulmon Dis 4:291-300. 2009..of fluoroquinolones have proven efficacy against bacterial organisms associated with acute exacerbation of chronic bronchitis (AECB)...
- Interleukin-4 and interleukin-5 gene expression and inflammation in the mucus-secreting glands and subepithelial tissue of smokers with chronic bronchitis. Lack of relationship with CD8(+) cellsJ Zhu
Department of Gene Therapy, Imperial College School of Medicine, London, United Kingdom
Am J Respir Crit Care Med 164:2220-8. 2001We wished to determine if the inflammatory cells surrounding the airway mucus-secreting glands in chronic bronchitis (CB) were associated with interleukin (IL)-4 and IL-5 mRNA expression and whether the CD8 T cell population expressed ..
- The association between home and vehicle environmental tobacco smoke (ETS) and chronic bronchitis in a Canadian population: the Canadian Community Health Survey, 2005Jessica Evans
Department of Epidemiology and Community Medicine, University of Ottawa, 451 Smyth Road, Ottawa, Ontario, Canada
Inhal Toxicol 21:244-9. 2009..to determine the association between home and vehicle exposure to environmental tobacco smoke (ETS), and chronic bronchitis based on data from 64,961 non-smokers aged 12 years and older who participated in the 2005 Canadian ..
- Treating acute exacerbations of chronic bronchitis and community-acquired pneumonia: how effective are respiratory fluoroquinolones?M Balter
Mount Sinai Hospital, Toronto, Ontario, Canada
Can Fam Physician 52:1236-42. 2006To provide family physicians with a review of evidence supporting fluoroquinolone therapy for defined patient populations with acute exacerbations of chronic bronchitis (AECB) and community-acquired pneumonia (CAP).
- Twins studies as a model for studies on the interaction between smoking and genetic factors in the development of chronic bronchitisMagnus Svartengren
Department of Public Health Science, Karolinska Institutet at Norrbacka, SE 171 76 Stockholm, Sweden
Biochem Soc Trans 37:814-8. 2009..Disease was defined as self-reported chronic bronchitis or emphysema, or recurrent cough with phlegm...
- The relation of body mass index to asthma, chronic bronchitis, and emphysemaStefano Guerra
Arizona Respiratory Center, College of Medicine, University of Arizona, 1501 N Campbell Avenue, Tucson, AZ 85724 5030, USA
Chest 122:1256-63. 2002..Recent studies have suggested a relationship between asthma and obesity. Despite these reports, the effect of being underweight or overweight as a risk factor for airway obstructive diseases (AODs) is not clear...
- Health-related QOL in acute exacerbations of chronic bronchitis and chronic obstructive pulmonary disease: a review of the literatureHelen Doll
Oxford Outcomes, Old Barn, Jericho Farm, Cassington, Oxford, UK
Pharmacoeconomics 23:345-63. 2005There is a lack of emphasis on health-related QOL (HR-QOL) changes associated with acute exacerbation of chronic bronchitis (CB) or chronic obstructive pulmonary disease (COPD)...
- Mortality in GOLD stages of COPD and its dependence on symptoms of chronic bronchitisMarie Ekberg-Aronsson
Department of Respiratory Medicine and Allergology, University of Lund, S 221 85 Lund, Sweden
Respir Res 6:98. 2005..The aims of this study were to investigate total mortality risks in GOLD stages 0-4 with special focus on stage 0, and furthermore to assess the influence of symptoms of chronic bronchitis on mortality risks in GOLD stages 1-4.
- The economic impact of acute exacerbations of chronic bronchitis in the United States and Canada: a literature reviewMichael T Halpern
Exponent Inc, Alexandria, VA 22314, USA
J Manag Care Pharm 9:353-9. 2003Acute exacerbations of chronic bronchitis (AECB) are recurrent and potentially severe medical events for the 13 million people in the United States who have chronic bronchitis...
- Interaction of atopy and smoking on respiratory effects of occupational dust exposure: a general population-based studyGea de Meer
Institute for Risk Assessment Science, Div, Environmental and Occupational Health, Utrecht University, P, O, Box 80176, 3508 TD Utrecht, The Netherlands
Environ Health 3:6. 2004..Assess relationship between airway obstruction and occupational exposure using a job-exposure-matrix (JEM) classifying jobs into 3 broad types of exposure, and test for effect modification by atopy, and smoking...
- Predictors of influenza vaccination in adults with chronic bronchitisRodrigo Jimenez-Garcia
Unidad de Docencia e Investigacion en Medicina Preventiva y Salud Publica, Facultad de Ciencias de la Salud, Avda de Atenas s n, 28402 Alcorcón, Madrid, Spain
Respir Med 103:1518-25. 2009Influenza vaccination is recommended for people with chronic bronchitis (CB) because they have a higher risk of influenza-related complications, hospitalizations, and death during seasonal influenza epidemics...
- Nontypeable Haemophilus influenzae in the lower respiratory tract of patients with chronic bronchitisV Bandi
Department of Medicine, Baylor College of Medicine, Houston, Texas 77030, USA
Am J Respir Crit Care Med 164:2114-9. 2001..in the lower respiratory tract was determined in healthy adults and in clinically stable and acutely ill chronic bronchitis (CB) patients...
- [Bacterial etiology of chronic bronchitis exacerbations treated by primary care physicians]Carles Llor
Centro de Salud Jaume I, Tarragona, Espana
Arch Bronconeumol 42:388-93. 2006Few studies have been carried out to determine the prevalence of microorganisms causing exacerbations of chronic bronchitis in the community setting...
- Traffic-related air pollution associated with prevalence of asthma and COPD/chronic bronchitis. A cross-sectional study in Southern SwedenAnna Lindgren
Department of Occupational and Environmental Medicine, Lund University, Lund, Sweden
Int J Health Geogr 8:2. 2009..A Geographical Information System (GIS) was used to link geocoded residential addresses to a Swedish road database and an emission database for NOx...
- Chronic bronchitis among nonsmoking farm women in the agricultural health studyMartin Valcin
Epidemiology, National Institute of Environmental Health Sciences, NIH, DHHS, Research Triangle Park, NC 27709 2233, USA
J Occup Environ Med 49:574-83. 2007The purpose of this study was to examine agricultural risk factors for chronic bronchitis among nonsmoking farm women.
- Appropriateness of antibiotic prescribing in veterans with community-acquired pneumonia, sinusitis, or acute exacerbations of chronic bronchitis: a cross-sectional studyColleen Cook Tobia
Department of Pharmacy, Veterans Affairs Pittsburgh Healthcare System, School of Pharmacy, University of Pittsburgh, Pittsburgh, Pennsylvania 15240 1000, USA
Clin Ther 30:1135-44. 2008....
- Intrapulmonary pharmacodynamics of high-dose levofloxacin in subjects with chronic bronchitis or chronic obstructive pulmonary diseaseJohn E Conte
Infectious Diseases Research Group, Department of Epidemiology and Biostatistics, University of California at San Francisco, 901F Health Sciences East, 513 Parnassus Avenue, San Francisco, CA 94143 0919, USA
Int J Antimicrob Agents 30:422-7. 2007....
- Variables associated with recovery from acute exacerbations of chronic bronchitis and chronic obstructive pulmonary diseaseMarc Miravitlles
Pneumology Department, Institut Clínic del Tòrax IDIBAPS, Red Respira FIS ISCIII RTIC 03 11, Hospital Clinic, Villarroel 170, 08036 Barcelona, Catalonia, Spain
Respir Med 99:955-65. 2005To identify risk factors for late recovery and failure after ambulatory treatment of exacerbations of chronic bronchitis (CB) and chronic obstructive pulmonary disease (COPD).
- How accurate is the self-reported diagnosis of chronic bronchitis?Arnel Bobadilla
Arizona Respiratory Center, University of Arizona, 1501 N Campbell Avenue, Tucson, AZ 85724 5030, USA
Chest 122:1234-9. 2002..for at least 3 months per year for at least 2 consecutive years, difficulties exist in the use of the term chronic bronchitis for clinical diagnosis...
- Reported prevalence and co-morbidity of asthma, chronic bronchitis and emphysema: a pan-European estimationS Boutin-Forzano
Epidemiology of Allergic and Respiratory Diseases, Unité Mixte de Recherche en Santé 707, Institut National de la Sante et de la Recherche Medicale, Paris, France
Int J Tuberc Lung Dis 11:695-702. 2007..Study conducted in random samples from eight European cities were used 1) to describe the prevalence of chronic bronchitis and emphysema (CBE) and asthma according to socio-demography, addictions, physical activities and body mass ..
- Antibiotics in acute exacerbations of chronic bronchitisSanjay Sethi
Division of Pulmonary and Critical Care Medicine, Department of Medicine, University at Buffalo SUNY Buffalo, NY, USA
Expert Rev Anti Infect Ther 8:405-17. 2010Acute exacerbations of chronic bronchitis (AECB) are a major contributor to morbidity and mortality in patients with chronic obstructive pulmonary disease, accounting for more than 16 million physician office visits and over 500,000 ..
- Optimizing ceftazidime pharmacodynamics in patients with acute exacerbation of severe chronic bronchitisAnnette Lubasch
Zentralklinik Emil v Behring, Department Lungenklinik Heckeshorn, Pneumologie I, Freie Universitat Berlin, Zum Heckeshorn 33, D 14109 Berlin
J Antimicrob Chemother 51:659-64. 2003..study, we evaluated the clinical and bacteriological outcome and pharmacokinetic as well as pharmacodynamic parameters of two ceftazidime therapy regimens in patients with acute exacerbation of severe chronic bronchitis (AECB).
- [Malnutrition in children with chronic bronchitis]S Viola
Service de gastroentérologie et nutrition pédiatrique, Hopital Armand Trousseau, Universite Pierre et Marie Curie Paris 6, Assistance Publique Hopitaux de Paris, 26 avenue du Docteur Arnold Netter, Paris, France
Arch Pediatr 15:1270-5. 2008To study nutritional status in children with chronic bronchitis (CB) in relation with lung function.
- Effect of sputum processing with dithiothreitol on the detection of inflammatory mediators in chronic bronchitis and bronchiectasisI S Woolhouse
Department of Medicine, Queen Elizabeth Hospital, Birmingham, UK
Thorax 57:667-71. 2002..to assess airway inflammation in patients with chronic obstructive pulmonary disease, including those with chronic bronchitis and bronchiectasis...
- Short-course antibiotic treatment in acute exacerbations of chronic bronchitis and COPD: a meta-analysis of double-blind studiesR El Moussaoui
Department of Internal Medicine, Division of Infectious Diseases, Tropical Medicine and AIDS and Center for Infection and Immunity Amsterdam CINIMA, Amsterdam, The Netherlands
Thorax 63:415-22. 2008..undertaken to determine whether a short course of antibiotic treatment (< or = 5 days) is as effective as the conventional longer treatment in acute exacerbations of chronic bronchitis and chronic obstructive pulmonary disease (COPD).
- Leisure time physical activity and disease-specific mortality among men with chronic bronchitis: evidence from the Whitehall studyG David Batty
Epidemiology Unit, Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, England
Am J Public Health 93:817-21. 2003This study examined the association between leisure time physical activity and cause-specific mortality among male Whitehall Study participants with chronic bronchitis.
- American Thoracic Society Statement: Occupational contribution to the burden of airway diseaseJohn Balmes
Am J Respir Crit Care Med 167:787-97. 2003
- Serum surfactant protein-A levels in chronic bronchitis and its relation to smokingD Behera
Department of Pulmonary Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, India
Indian J Chest Dis Allied Sci 47:13-7. 2005..Little is known on the SP-A levels in patients with chronic obstructive pulmonary disease (COPD)...
- Acute exacerbations of chronic bronchitis: new developments concerning microbiology and pathophysiology--impact on approaches to risk stratification and therapySanjay Sethi
Division of Pulmonary and Critical Care Medicine, Department of Medicine, University at Buffalo SUNY, Buffalo, NY 14260, USA
Infect Dis Clin North Am 18:861-82, ix. 2004..This article discusses a rational, stratified approach to the use of antibiotics for this condition based on these recent studies...
- Risk of depression and anxiety in employees with chronic bronchitis: the modifying effect of cigarette smokingEdwin J Wagena
Department of General Practice, Care and Public Health Research Institute, Maastricht University, Maastricht, The Netherlands
Psychosom Med 66:729-34. 2004The present study evaluates whether smoking status modifies the association between chronic bronchitis and depression or anxiety in a population-based sample...
- Prulifloxacin: a brief review of its potential in the treatment of acute exacerbation of chronic bronchitisFrancesco Blasi
Institute of Respiratory Diseases, University of Milan, Fondazione IRCCS Policlinico Mangiagalli Regina Elena, Milano, Italy
Int J Chron Obstruct Pulmon Dis 2:27-31. 2007Exacerbations of chronic bronchitis (AECB) are a major cause of morbidity and mortality in patients with chronic obstructive pulmonary disease (COPD), and their impact on public health is increasing...
- Short- versus long-duration antimicrobial treatment for exacerbations of chronic bronchitis: a meta-analysisMatthew E Falagas
Alfa Institute of Biomedical Sciences AIBS, Athens, Greece
J Antimicrob Chemother 62:442-50. 2008The aim of this study was to evaluate the comparative effectiveness and safety of short (5 days) and long (7 or 10 days) duration antimicrobial treatment of patients with acute exacerbations of chronic bronchitis (AECB).
- Comparison between various indices of exposure to traffic-related air pollution and their impact on respiratory health in adultsG Cesaroni
Epidemiology Department, Local Health Unit, ASL RME, Via S Costanza 53, 00198 Rome, Italy
Occup Environ Med 65:683-90. 2008....
- Prospective observational study of patient-reported outcomes for azithromycin versus usual care in the treatment of bacterial acute exacerbation of chronic bronchitisAaron Milstone
Pulmonary Division, Vanderbilt University Medical Center, Nashville, TN 37232, USA
Clin Ther 27:926-39. 2005..The 3-day course of azithromycin (AZM) 500 mg/d was introduced to the US market in June 2002...
- Smoking: relationship to chronic bronchitis, chronic obstructive pulmonary disease and mortalityMargit Pelkonen
Department of Pulmonary Diseases, Kuopio University Hospital, Kuopio, Finland
Curr Opin Pulm Med 14:105-9. 2008To describe the recent findings concerning the relationship between smoking, chronic bronchitis, chronic obstructive pulmonary disease and mortality.
- Specific nasal symptoms and symptom-provoking factors may predict increased risk of developing COPDUlf Nihlen
Respiratory Medicine and Allergology, Lund University Hospital, Lund, Sweden
Clin Physiol Funct Imaging 28:240-50. 2008..that certain nasal symptoms and symptom-provoking factors were associated with prevalence of self-reported chronic bronchitis/emphysema (CBE)...
- Appropriate outpatient treatment of acute bacterial exacerbations of chronic bronchitisFernando J Martinez
University of Michigan Health System, Ann Arbor, Michigan, USA
Am J Med 118:39S-44S. 2005Acute exacerbations of chronic bronchitis (AECB), which are characteristic of chronic obstructive pulmonary disease (COPD), contribute to morbidity and decreased quality of life for patients with COPD...
- Pneumocystis jiroveci isolates with dihydropteroate synthase mutations in patients with chronic bronchitisE Calderon
Department of Internal Medicine, Virgen del Rocio University Hospital, Seville, Spain
Eur J Clin Microbiol Infect Dis 23:545-9. 2004..jiroveci DHPS mutations in patients with chronic bronchitis. P...
- Relationship of airway epithelial ion transport to chronic bronchitisRichard C Boucher
Cystic Fibrosis Pulmonary Research and Treatment Center, University of North Carolina at Chapel Hill, CB number 7248, 7011 Thurston Bowles, Chapel Hill, NC 27599 7248, USA
Proc Am Thorac Soc 1:66-70. 2004Failure to clear mucus normally is a critical event in the pathogenesis of chronic bronchitis (CB)...
- Comparison of first-line with second-line antibiotics for acute exacerbations of chronic bronchitis: a metaanalysis of randomized controlled trialsGeorge Dimopoulos
Alfa Institute of Biomedical Sciences AIBS, 9 Neapoleos St, 151 23 Marousi, Greece
Chest 132:447-55. 2007Although acute exacerbations of chronic bronchitis (AECBs) are common, there has been no metaanalysis that focused on the optimum regimen.
- Imaging of the patient with chronic bronchitis: an overview of old and new signsM Zompatori
Dipartimento di Scienze Cliniche, Sezione di Diagnostica per Immagini, Universita di Parma, Parma, Italy
Radiol Med 111:634-9. 2006..nor high-resolution computed tomography (HRCT) has much to offer to the diagnosis of patients with chronic bronchitis (CB). A lot of HRCT findings can be observed, but they cannot be regarded as specific for pure CB...
- Economic evaluation of the antibiotic treatment of exacerbations of chronic bronchitis and COPD in primary careC Llor
Infectious Diseases Group of the Catalan Society of Family Medicine, Barcelona, Spain
Int J Clin Pract 58:937-44. 2004..to assess the effectiveness and direct medical costs derived from antibiotic treatment of exacerbations of chronic bronchitis (CB) and chronic obstructive pulmonary disease (COPD) in primary care...
- Chronic bronchitis and urban air pollution in an international studyJ Sunyer
Centre de Recerca en Epidemiologia Ambiental, Institut Municipal Investigacio Medica, Barcelona, Spain
Occup Environ Med 63:836-43. 2006The chronic effects of urban air pollution are not well known. The authors' aim was to investigate the association between the prevalence and new onset of chronic bronchitis and urban air pollution.
- Clinical and bacteriological efficacy in treatment of acute exacerbations of chronic bronchitis with cefditoren-pivoxil versus cefuroxime-axetilJose Luis Alvarez-Sala
Microbiology Department, School of Medicine, Universidad Complutense, Avda Complutense s n, 28040 Madrid, Spain
Antimicrob Agents Chemother 50:1762-7. 2006..treatment (250 mg twice daily for 10 days) of Anthonisen type I or II acute exacerbations of chronic bronchitis. The modified intention-to-treat population included 541 patients...
- Clinical efficacy of OM-85 BV in COPD and chronic bronchitis: a systematic reviewMark D Sprenkle
Division of Pulmonary and Critical Care Medicine, Hennepin County Medical Center, Pulmonary Medicine 865B, 701 Park Ave, Minneapolis, Minnesota 55415, USA
COPD 2:167-75. 2005..Studies were included if they involved persons with chronic obstructive pulmonary disease or chronic bronchitis and were randomized to OM-85 BV or placebo...
- Antibiotic treatment and factors influencing short and long term outcomes of acute exacerbations of chronic bronchitisR Wilson
Royal Brompton Hospital, Sydney Street, London SW3 6NP, UK
Thorax 61:337-42. 2006..with three standard antibiotic regimens in patients with Anthonisen type 1 acute exacerbations of chronic bronchitis (AECB)...
- Study entry microbiology in patients with acute bacterial exacerbation of chronic bronchitis in a clinical trial stratifying by disease severityJames B Kahn
PriCara, Unit of Ortho McNeil, Inc, Raritan, NJ 08869, USA
Curr Med Res Opin 23:1-7. 2007To examine study entry microbiology in patients stratified by disease severity in a clinical trial in acute bacterial exacerbation of chronic bronchitis (ABECB).
- Effect of salmeterol on mucociliary and cough clearance in chronic bronchitisWilliam D Bennett
Center for Environmental Medicine, Asthma and Lung Biology, University of North Carolina at Chapel Hill, 27599, USA
Pulm Pharmacol Ther 19:96-100. 2006The effect of long acting beta(2)-adrenergic bronchodilators on impaired mucociliary clearance in chronic bronchitis is unknown...
- Prulifloxacin: a new fluoroquinolone for the treatment of acute exacerbation of chronic bronchitisMario Cazzola
Department of Pneumology, Unit of Pneumology and Allergology, A Cardarelli Hospital, Via del Parco Margherita 24, 80121 Naples, Italy
Pulm Pharmacol Ther 19:30-7. 2006Empiric therapy with oral antibiotics is normal practice in the treatment of acute exacerbations of chronic bronchitis (AECB), but there is growing concern regarding efficacy of the currently available antimicrobials...
- A review of guidelines for antibacterial use in acute exacerbations of chronic bronchitisFrancesco Blasi
Pad LITTA, IRCCS Ospedale Maggiore Policlinico, Via F Sforza, 35, 20122, University of Milan, Policlinico, Milan, Italy
Pulm Pharmacol Ther 19:361-9. 2006Acute exacerbations of chronic bronchitis (AECB) affect a significant proportion of the adult population worldwide and are associated with a substantial socioeconomic burden...
- Acute exacerbation of chronic bronchitis: a primary care consensus guidelineStephen Brunton
Department of Family Medicine, University of California, Irvine, Calif, USA
Am J Manag Care 10:689-96. 2004To develop consensus on appropriate treatment for acute exacerbation of chronic bronchitis (AECB)...
- Five-day moxifloxacin therapy compared with 7-day co-amoxiclav therapy for the treatment of acute exacerbation of chronic bronchitisI Starakis
Department of Internal Medicine, Infectious Diseases Section, University Hospital, 26500 Rion Patras, Greece
Int J Antimicrob Agents 23:129-37. 2004..that of co-amoxiclav (one 625 mg tablet every 8h) for 7 days, for the treatment of acute exacerbations of chronic bronchitis (AECB)...
- EPITHELIAL CELL RESPONSE TO H.INFLUENZAE IN THE AIRWAYDwight Look; Fiscal Year: 2003..human respiratory mucosa and often produces respiratory tract disease, particularly in patients with chronic bronchitis, bronchiectasis, and cystic fibrosis...
- BIOSYNTHESIS OF TRACHEAL MUCOUS GLYCOPROTEINSPi Wan Cheng; Fiscal Year: 2010Mucus hypersecretion is a hallmark of obstructive lung diseases, including chronic bronchitis, asthma, and cystic fibrosis. This condition is the result of hypertrophy and hyperplasia of mucus cells...
- Neurotrophins in the LungY S Prakash; Fiscal Year: 2012..airway narrowing and accompanying shortness of breath in clinically important diseases such as asthma and chronic bronchitis. In this regard, the potential role of growth factors called neurotrophins in regulation of airway ..
- ROLE OF SIRTUIN IN CIGARETTE SMOKE-INDUCED LUNG INFLAMMATION AND INJURYIrfan Rahman; Fiscal Year: 2013..COPD (emphysema and chronic bronchitis) is linked with premature aging (accelerated decline in lung function) and chronic inflammation of the lungs ..
- Mechanism Underlying Nitrite Sensitivity of Mucoid Pseudomonas in COPDDaniel J Hassett; Fiscal Year: 2013..HEALTH RELEVANCE: Chronic obstructive pulmonary disease (COPD) is a debilitating lung disorder encompassing chronic bronchitis and/or emphysema, and characterized by nonreversible airflow limitation...
- Anti-Bacterial Innate Responses Enhance Paramyxovirus ReplicationGriffith D Parks; Fiscal Year: 2010..infections involving bacteria and paramyxoviruses are a significant factor in human patients with chronic bronchitis, sinusitis and otitis media...
- Iowa Phase II Clinical Trials of Novel Therapies for Lung Diseases (U01Lakshmi Durairaj; Fiscal Year: 2012..a cheap and effective intervention for several conditions in addition to CF, such as non-CF bronchiectasis, chronic bronchitis and ventilator associated pneumonia...
- Development of Bioactive Chemical Probes for Calcium-activated Chloride ChannelMin Li; Fiscal Year: 2012..Abnormality of CaCC is thought to be causal to diseases, such as cystic fibrosis, asthma, chronic bronchitis, and hypertension...
- MNEI/SerpinB1: A modulator of innate pulmonary defenseEILEEN REMOLD-O'DONNELL; Fiscal Year: 2010..which an aggressive host response leads to lung injury as occurs in patients with cystic fibrosis and COPD (chronic bronchitis, emphysema) will provide understanding that may lead to improved treatment...
- Mechanisms of oxidant-induced chronic bronchitisROSANNA C MALBRAN FORTEZA; Fiscal Year: 2012..is to understand the cellular and molecular mechanisms that lead to the structural changes associated with chronic bronchitis. This application continues our focus on oxidative stress-induced EGFR activation and mucus hypersecretion...
- Abnormality in Gene Expression of Key Mediators of Vitamin A Action in COPDSalil K Das; Fiscal Year: 2010b>Chronic bronchitis and emphysema are two kinds of chronic obstructive pulmonary disease (COPD), which are important causes of morbidity and mortality in the United States...
- Developing Nrf2 as a target for treatment of corticosteroid resistance in COPDRobert A Wise; Fiscal Year: 2012..Abnormal airway inflammation is thought to contribute to chronic bronchitis, small-airway obstruction and emphysema...
- Spinal Cord-Mediated Acute Neurogenic InflammationQing Lin; Fiscal Year: 2010..contributes to many clinically relevant states, including arthritis, inflammatory bowel disease, chronic bronchitis, migraine and interstitial cystitis...
- BIOLOGY OF SUBMUCOSAL GLAND STEM CELLS IN THE AIRWAYJohn F Engelhardt; Fiscal Year: 2013..In diseases such as cystic fibrosis (CF), asthma, and chronic bronchitis, Submucosal glands expand in mass (hypertrophy) and/or abundance (hyperplasia), leading to excessive and ..
- Pulmonary Vasoreactivity Following Chronic HypoxiaThomas C Resta; Fiscal Year: 2012..PUBLIC HEALTH RELEVANCE: Chronic obstructive pulmonary diseases (COPD) such as emphysema and chronic bronchitis are established major causes of mortality and morbidity in the U.S...
- Role of the Aryl Hydrocarbon Receptor in Lung InflammationPATRICIA JANET SIME; Fiscal Year: 2012..cigarette smoke is the primary cause of chronic obstructive pulmonary disease (COPD-emphysema and chronic bronchitis)...
- Airway epithelial repair in chronic bronchitis: novel signaling mechanismsAndreas Schmid; Fiscal Year: 2013..Chronic inflammatory airway diseases, including smoking-induced chronic bronchitis, lead to damage of the airway epithelium with subsequent impairment of mucociliary clearance, a condition ..
- Airway epithelial repair in chronic bronchitis: novel signaling mechanismsAndreas Schmid; Fiscal Year: 2011..Chronic inflammatory airway diseases, including smoking-induced chronic bronchitis, lead to damage of the airway epithelium with subsequent impairment of mucociliary clearance, a condition ..
- Signaling Sphingolipids in COPDIrina Petrache; Fiscal Year: 2009..End of Abstract) PUBLIC HEALTH RELEVANCE: PROJECT NARRATIVE Pulmonary emphysema and chronic bronchitis comprise the spectrum of COPD, a prevalent fatal disease...
- The Role of Caveolins in Lung InflammationCHRISTINA MARIA PABELICK; Fiscal Year: 2013..airway narrowing and accompanying shortness of breath in clinically- important diseases such as asthma and chronic bronchitis. In this regard, the potential role of cellular structures called caveolae and their constituent caveolin ..
- Calcium Regulation in Airway Smooth MuscleGary C Sieck; Fiscal Year: 2013..airway narrowing and accompanying shortness of breath in clinically-important diseases such as asthma and chronic bronchitis. Airway contractility is highly dependent on intracellular calcium levels...
- GST alleles and oxidant pollutants in the pathogenesis of asthmaBeverly H Koller; Fiscal Year: 2010..support a role for polymorphism in this gene family in determination of risk of developing asthma, COPD, chronic bronchitis and occupational lung disease...
- Pathogenic Mechanism for Lung Infection in Mucoid PseudomonasDENNIS EDWARD OHMAN; Fiscal Year: 2013..This can occur as a complication of emphysema, chronic bronchitis, cancer and immunosuppressive drug therapy...
- Molecular Genetics of Pathogen Recognition Receptors in COPDTricia D LeVan; Fiscal Year: 2013..bind Gram (+) and Gram (-) bacterial components, as well as fungal components, are associated with COPD, chronic bronchitis symptoms and/or lung function;and to determine whether there is an association of these polymorphisms with ..
- Resolution of Epithelial Cell HyperplasiaYohannes Tesfaigzi; Fiscal Year: 2013..MCM is one of the major factors for increased mucous hypersecretion in chronic bronchitis. We have shown that Bcl-2, an inhibitor of apoptosis, sustains MCM in rats and mice and may have clinical ..
- Molecular Pathways Regulating Airway Goblet Cell Mucin SecretionBurton F Dickey; Fiscal Year: 2013..substantially increases patient morbidity and mortality in literally all the airways diseases, common ones (chronic bronchitis and asthma) and orphan ones (cystic fibrosis and primary ciliary dyskinesia) alike, irrespective of the ..
- Novel Reagents in Mouse Models of Autoimmune COPDMichael Borchers; Fiscal Year: 2012..COPD, which includes chronic bronchitis and emphysema, is a major global health burden and morbidity and mortality are expected to expand in the ..
- Microfluidic Tissue Engineering of Small Airway InjuriesShuichi Takayama; Fiscal Year: 2010In diseases that involve mucus secretion and movement in the small airways, such as chronic bronchitis, cystic fibrosis or asthma, liquid plugs form occluding bridges that obstruct the airway and disrupt gas exchange...
- Targeting Airway Inflammation from Concentrated Animal Feeding Operation DustDebra Romberger; Fiscal Year: 2013..in concentrated animal feeding operations (CAFOs) experience work-related respiratory disease, particularly chronic bronchitis and chronic obstructive pulmonary disease (COPD)...
- The Pathobiology of Airway Disease in Alpha-1 Antitrypsin DeficiencyMichael A Campos; Fiscal Year: 2010..The overall goal of the research project is to understand the pathogenesis of airway inflammation and chronic bronchitis in AATD, a condition significantly associated with the worst quality of life and more severe airway disease ..
- The Impact of Tobacco Exposure on the Lungs Innate Defense SystemRobert Tarran; Fiscal Year: 2013..we propose to develop a novel animal model of smoke exposure that more closely mimics the chronic bronchitis phenotype seen in humans with COPD...
- HDL cholesterol and chronic lower respiratory disease events in five cohortsR Graham Barr; Fiscal Year: 2013..The most prevalent components of CLRD are chronic obstructive pulmonary disease (COPD), emphysema, chronic bronchitis and asthma...
- Optimizing vascular protective effects of antitrypsin in COPDIrina Petrache; Fiscal Year: 2013DESCRIPTION (provided by applicant): ABSRACT: Emphysema and chronic bronchitis comprise the syndrome of COPD, now surpassing stroke as the 3rd leading cause of death in the US and a highly prevalent disease in Veterans...
- Severe Asthma Research Program (SARP)-Washington UniversityMario Castro; Fiscal Year: 2013..these findings to those in groups with well- controlled asthma, normal controls, and diseased controls (chronic bronchitis) to identify features that can provide biologic targets unique to severe asthma...
- Airway Inspector: a chest imaging biomarker software platform for COPDRaul San Jose Estepar; Fiscal Year: 2013..COPD has been traditionally dichotomized into the clinical phenotypes of emphysema and chronic bronchitis. Although spirometry is critical for diagnosis of COPD, FEV1 may be of limited value in a classification ..
- The A2a adenosine receptor modulates hyaluronan mediated lung inflammationMAUREEN RENEE HORTON; Fiscal Year: 2010..We believe that these studies will provide the pre-clinical basis for the use of A2aR specific agonists in the treatment of inflammatory lung diseases such as idiopathic pulmonary fibrosis, chronic bronchitis and emphysema.
- Pharmacological characterization of a novel ROCK inhibitor for COPDXiaoming Zhang; Fiscal Year: 2010..efficacious ROCK inhibitor as maintenance therapy for airflow obstruction in patients with COPD, including chronic bronchitis and emphysema. Theron has identified a highly potent inhibitor of the human ROCK-1 and ROCK-2 isoenzymes...
- The Role of Anaerobic Bacterial Infection in Cystic FibrosisRICHARD CHARLES BOUCHER; Fiscal Year: 2013..g., chronic bronchitis. Such observations might change the way physicians approach antibiotic therapy of patients with airways ..
- Antibiofilm/Antimicrobial Combination for Infections Associated with Vascular CatMohammad D Mansouri; Fiscal Year: 2010..a systemic remedy against toxicity with acetaminophen, is also used for inhalation therapy in patients with chronic bronchitis by breaking up the mucus...
- Th17 inflammation is responsible for mucous metaplasia in COPDVictor Kim; Fiscal Year: 2013DESCRIPTION (provided by applicant): Chronic mucus hypersecretion (CMH) and chronic bronchitis (CB) are variable but significant symptoms in COPD...
- Common targeting of the prostacyclin-PPARy axis in COPD and lung cancerRubin M Tuder; Fiscal Year: 2013DESCRIPTION (provided by applicant): Smokers with the overlapping COPD phenotypes of airflow obstruction, chronic bronchitis or emphysema carry a significantly higher risk of developing lung cancer, as two recent studies indicated that ..
- Hyaluronan-induced signaling and gene regulationMAUREEN RENEE HORTON; Fiscal Year: 2010..We believe that these studies will provide the pre-clinical basis for the use of specific agents in the treatment of inflammatory lung dis13ases such as idiopathic pulmonary fibrosis, chronic bronchitis and emphysema.
- Clinical Development of a Therapeutic Agent for COPDIndu Parikh; Fiscal Year: 2013..under an active IND, a 21-day proof-of-concept Phase 2A clinical study in 172 COPD patients suffering from chronic bronchitis with its lead compound BIO-11006...
- LUNG DISEASE IN CHINESE TEXTILE WORKERSDavid C Christiani; Fiscal Year: 2013..Specifically, for over five decades, controversy continues as to whether emphysema or chronic bronchitis is the basis of the observed airway obstruction...
- Mucociliary Function in Chronic BronchitisMATTHIAS A SALATHE; Fiscal Year: 2010DESCRIPTION (provided by applicant): In chronic bronchitis, mucociliary clearance is dysfunctional, especially during disease exacerbation...
- The Genetic Epidemiology of COPD in Costa RicaJUAN CARLOS CELEDON; Fiscal Year: 2009..using short-tandem repeat (STR) markers and perform linkage analysis of six COPDrelated phenotypes: chronic bronchitis;airflow obstruction;FEV1;FEV1/FVC;bronchodilator responsiveness;and total serum IgE...
- Mucus Adhesion to Epithelial Cells and its Mobilization in COPD and CFMichael Rubinstein; Fiscal Year: 2012..RELEVANCE (See Instructions): Chronic bronchitis (CB) is caused by both genetic and environmental factors and affects more than 14 million Americans...
- Pulmonary bacterial microbiome-epithelial cell interactions in COPDFernando J Martinez; Fiscal Year: 2013..of the EGFR pathway and mucin induction, thereby contributing to airway obstruction and symptoms of chronic bronchitis in COPD patients. This process will be ameliorated by a PDE4 inhibitor...
- Measures of Dust, Endotoxin, and Exhaled Nitric Oxide among Dairy Farm WorkersMATTHEW WINSTON NONNENMANN; Fiscal Year: 2012..The presence of lung inflammation may also be an indicator of asthma, chronic bronchitis, or chronic obstructive pulmonary disease (COPD)...
- Novel Mucolytic AgentsBILL THELIN; Fiscal Year: 2013..system characterize a complex of muco-obstructive airway diseases, such as cystic fibrosis (CF) and chronic bronchitis (CB). CB associated with CF affects 30,000 Americans, and the CB associated with environmental causes, e.g...
- Multidisciplinary Research Training in Pulmonary MedicineDavid B Jacoby; Fiscal Year: 2012..These scientists will be prepared to address the public health issues raised by the increasing burden of asthma, chronic bronchitis, emphysema, acute respiratory distress syndrome, and other lung diseases.
- Quercetin Treatment of Airway InflammationMARC HERSHENSON; Fiscal Year: 2006Inflammatory airways diseases - asthma, chronic bronchitis and cystic fibrosis - remain important causes of morbidity and mortality in the U.S...
- Hyperpolarized xenon functional MRI of human lung microstructureIULIAN RUSET; Fiscal Year: 2009Chronic Obstructive Pulmonary Disease (COPD), including emphysema and chronic bronchitis, is the fourth leading cause of death in the US, accounting for 120,000 fatalities annually...
- MACROPHAGE/NEUTROPHIL ELASTASE INHIBITOREILEEN REMOLD O DONNELL; Fiscal Year: 1999..proteinase inhibitors at tissue sites plays a role in the pathogenesis of emphysema, bronchiectasis, asthma, chronic bronchitis, sarcoidosis, respiratory distress syndrome, arthritis and some skin diseases...
- INHALED PARTICLE CHARACTERISTICS AND EARLY LUNG EFFECTSWilliam Beckett; Fiscal Year: 2002..Investigator's Abstract) Chronic obstructive pulmonary disease (COPD) is a disabling condition produced by chronic bronchitis (airway inflammation and mucus hypersecretion) and emphysema (loss of alveolar surface area)...
- PLAGL2 Expression in Emphysema Patient LungsYih Sheng Yang; Fiscal Year: 2009..staining of tissue sections from patients with histologic evidence of emphysema, COPD with predominantly chronic bronchitis, or controls...
- Regulation of Airway Goblet Cell Mucin SecretionC Davis; Fiscal Year: 2007DESCRIPTION: The obstructive pulmonary diseases (OPD), cystic fibrosis, chronic bronchitis, bronchiectasis, emphysema, and asthma, are inflammatory diseases with very different inflammatory cell profiles, cytokine responses, etc; mucin ..
- Protease Regulation of Airway Cell Sodium TransportRobert Bridges; Fiscal Year: 2005..respiratory diseases including cystic fibrosis, chronic obstructive pulmonary disease, asthma and acute and chronic bronchitis. Pharmacological modulation of Na+ transport is expected to improve mucociliary clearance in these diseases...
- POLYMERIC STRUCTURE OF MUCOUS GLYCOPROTEINSVeer Bhavanandan; Fiscal Year: 1993..Mucins are believed to have a significant role in a variety of pathophysiologic processes including asthma, chronic bronchitis, cystic fibrosis, peptic ulcers, chronic gastritis, infertility and inflammatory bowel diseases...
- COAL DUST PARTICLE SIZE AND RESPIRATORY DISEASEThomas Robins; Fiscal Year: 1991..of particle size fractions and temporal aspects of exposure to coal mine dust to the development of chronic bronchitis and airways obstruction in underground coal miners...
- PATHOPHYSIOLOGY OF AIRWAY EFFECTS TO COLD EXPOSUREEDWARD MCFADDEN; Fiscal Year: 1999..the pulmonary mechanical effects of cold exposure in health and in subjects with asthma, rhinitis, and chronic bronchitis; (2) determine the mechanisms by which skin cooling produces bronchial narrowing; (3) evaluate whether cold ..
- BTP1000 & The Clearance of Mucus From the LungsDONOVAN YEATES; Fiscal Year: 2002Patients with chronic bronchitis, bronchiectasis, cystic fibrosis, asthmatic bronchitis and asthma have inspissated mucus and plugs of highly viscoelastic mucus...
- ANALYSIS OF THE AIRWAY ANTIPROTEINASE DEFENSE SYSTEMSule Cataltepe; Fiscal Year: 2006..play a major role in the development of inflammatory lung diseases such as cystic fibrosis, asthma, chronic bronchitis, emphysema and chronic lung disease of prematurity...