chronic bronchitis

Summary

Summary: A subcategory of CHRONIC OBSTRUCTIVE PULMONARY DISEASE. The disease is characterized by hypersecretion of mucus accompanied by a chronic (more than 3 months in 2 consecutive years) productive cough. Infectious agents are a major cause of chronic bronchitis.

Top Publications

  1. ncbi [Effect of Eucalyptus globulus oil on lipopolysaccharide-induced chronic bronchitis and mucin hypersecretion in rats]
    Xiao qin Lu
    Zhejiang Respiratory Drugs Research Laboratory of State Food and Drugs Administration of China, College of Medical Sciences, Zhejiang University, Hangzhou 310031, China
    Zhongguo Zhong Yao Za Zhi 29:168-71. 2004
  2. ncbi COPD and chronic bronchitis risk of indoor air pollution from solid fuel: a systematic review and meta-analysis
    Om P Kurmi
    Institute of Occupational and Environmental Medicine, School of Population and Health Sciences, University of Birmingham, Birmingham B15 2TT, UK
    Thorax 65:221-8. 2010
  3. ncbi Chronic bronchitis before age 50 years predicts incident airflow limitation and mortality risk
    S Guerra
    Arizona Respiratory Center, University of Arizona, Tucson, AZ 85724 5030, USA
    Thorax 64:894-900. 2009
  4. pmc Development of chronic bronchitis and emphysema in beta-epithelial Na+ channel-overexpressing mice
    Marcus A Mall
    Pediatric Pulmonology and Cystic Fibrosis Center, Department of Pediatrics III, University of Heidelberg, Im Neuenheimer Feld 153, 69120 Heidelberg, Germany
    Am J Respir Crit Care Med 177:730-42. 2008
  5. pmc Resolution of bronchial inflammation is related to bacterial eradication following treatment of exacerbations of chronic bronchitis
    A J White
    Department of Respiratory Medicine, Queen Elizabeth Hospital, Birmingham B15 2TH, UK
    Thorax 58:680-5. 2003
  6. ncbi Acute exacerbations of chronic bronchitis in elderly patients: pathogenesis, diagnosis and management
    Don Hayes
    Department of Pediatrics, University of Kentucky College of Medicine, Lexington, Kentucky, USA
    Drugs Aging 24:555-72. 2007
  7. ncbi Predictors of chronic bronchitis in South African adults
    R I Ehrlich
    School of Public Health and Family Medicine, University of Cape Town, Cape Town, South Africa
    Int J Tuberc Lung Dis 8:369-76. 2004
  8. ncbi Variation of CD8+ T-lymphocytes around the bronchial internal perimeter in chronic bronchitis
    E Gamble
    Lung Pathology, Dept of Gene Therapy, Imperial College London at the Royal Brompton Hospital, London, UK
    Eur Respir J 22:992-5. 2003
  9. ncbi Upregulation of basic fibroblast growth factor in smokers with chronic bronchitis
    F Guddo
    Pathology Unit, V Cervello Hospital, Palermo, Italy
    Eur Respir J 27:957-63. 2006
  10. pmc Interaction between smoking and genetic factors in the development of chronic bronchitis
    Jenny Hallberg
    Department of Occupational and Environmental Health, Norrbacka, Karolinska Hospital, SE 171 76 Stockholm, Sweden
    Am J Respir Crit Care Med 177:486-90. 2008

Detail Information

Publications255 found, 100 shown here

  1. ncbi [Effect of Eucalyptus globulus oil on lipopolysaccharide-induced chronic bronchitis and mucin hypersecretion in rats]
    Xiao qin Lu
    Zhejiang Respiratory Drugs Research Laboratory of State Food and Drugs Administration of China, College of Medical Sciences, Zhejiang University, Hangzhou 310031, China
    Zhongguo Zhong Yao Za Zhi 29:168-71. 2004
    To study the effect of Eucalyptus globulus oil on bronchiolitis and mucin hypersecretion in chronic bronchitis induced by lipopolysaccharide in rats.
  2. ncbi COPD and chronic bronchitis risk of indoor air pollution from solid fuel: a systematic review and meta-analysis
    Om P Kurmi
    Institute of Occupational and Environmental Medicine, School of Population and Health Sciences, University of Birmingham, Birmingham B15 2TT, UK
    Thorax 65:221-8. 2010
    ..The aim of this systematic review was to quantify the impact of biomass smoke on the development of COPD and define reasons for differences in the reported effect sizes...
  3. ncbi Chronic bronchitis before age 50 years predicts incident airflow limitation and mortality risk
    S Guerra
    Arizona Respiratory Center, University of Arizona, Tucson, AZ 85724 5030, USA
    Thorax 64:894-900. 2009
    Previous studies on the relationship of chronic bronchitis to incident airflow limitation and all-cause mortality have provided conflicting results, with positive findings reported mainly by studies that included populations of young ..
  4. pmc Development of chronic bronchitis and emphysema in beta-epithelial Na+ channel-overexpressing mice
    Marcus A Mall
    Pediatric Pulmonology and Cystic Fibrosis Center, Department of Pediatrics III, University of Heidelberg, Im Neuenheimer Feld 153, 69120 Heidelberg, Germany
    Am J Respir Crit Care Med 177:730-42. 2008
    ..Previous studies have shown that airway surface dehydration in beta-epithelial Na(+) channel (betaENaC)-overexpressing mice caused a chronic lung disease with high neonatal pulmonary mortality and chronic bronchitis in adult survivors.
  5. pmc Resolution of bronchial inflammation is related to bacterial eradication following treatment of exacerbations of chronic bronchitis
    A J White
    Department of Respiratory Medicine, Queen Elizabeth Hospital, Birmingham B15 2TH, UK
    Thorax 58:680-5. 2003
    Recent studies of the role of bacteria in chronic bronchitis have shown that bacterial colonisation is associated with enhanced inflammation and that purulent acute exacerbations of chronic bronchitis (AECB) are associated with bacteria ..
  6. ncbi Acute exacerbations of chronic bronchitis in elderly patients: pathogenesis, diagnosis and management
    Don Hayes
    Department of Pediatrics, University of Kentucky College of Medicine, Lexington, Kentucky, USA
    Drugs Aging 24:555-72. 2007
    b>Chronic bronchitis (CB) is a disorder that is characterised by chronic mucus production. This disorder is called chronic obstructive pulmonary disease (COPD) when airflow obstruction is present...
  7. ncbi Predictors of chronic bronchitis in South African adults
    R I Ehrlich
    School of Public Health and Family Medicine, University of Cape Town, Cape Town, South Africa
    Int J Tuberc Lung Dis 8:369-76. 2004
    ..National household survey of adults in South Africa, a middle income country...
  8. ncbi Variation of CD8+ T-lymphocytes around the bronchial internal perimeter in chronic bronchitis
    E Gamble
    Lung Pathology, Dept of Gene Therapy, Imperial College London at the Royal Brompton Hospital, London, UK
    Eur Respir J 22:992-5. 2003
    ..of CD8+ cells has been determined around the internal perimeter of intrapulmonary bronchi in smokers with chronic bronchitis (CB), and the amount of tissue required to confidently estimate the true mean has been calculated...
  9. ncbi Upregulation of basic fibroblast growth factor in smokers with chronic bronchitis
    F Guddo
    Pathology Unit, V Cervello Hospital, Palermo, Italy
    Eur Respir J 27:957-63. 2006
    ..bFGF) and its receptor, fibroblast growth factor receptor (FGFR)-1, in the central airways of smokers with chronic bronchitis. The lobar bronchi from 17 subjects undergoing thoracotomy for solitary nodules were examined...
  10. pmc Interaction between smoking and genetic factors in the development of chronic bronchitis
    Jenny Hallberg
    Department of Occupational and Environmental Health, Norrbacka, Karolinska Hospital, SE 171 76 Stockholm, Sweden
    Am J Respir Crit Care Med 177:486-90. 2008
    Smoking is a primary risk factor for chronic bronchitis, emphysema, and chronic obstructive pulmonary disease, but since not all smokers develop disease, it has been suggested that some individuals may be more susceptible to exogenous ..
  11. ncbi Animal models of chronic bronchitis and their relevance to studies of particle-induced disease
    K J Nikula
    Lovelace Respiratory Research Institute, Albuquerque, New Mexico, USA
    Inhal Toxicol 12:123-53. 2000
    b>Chronic bronchitis is a significant cause of morbidity and mortality...
  12. ncbi Responsiveness of the cough and sputum assessment questionnaire in exacerbations of COPD and chronic bronchitis
    Brigitta U Monz
    Boehringer Ingelheim GmbH, Binger Strasse 173, D 55216 Ingelheim, Germany
    Respir Med 104:534-41. 2010
    To assess the responsiveness of the Cough and Sputum Assessment Questionnaire (CASA-Q) in COPD and chronic bronchitis patients recovering from an acute exacerbation...
  13. ncbi Double-blind study of OM-85 in patients with chronic bronchitis or mild chronic obstructive pulmonary disease
    M Soler
    Pneumologie, St Claraspital, Basel, Switzerland
    Respiration 74:26-32. 2007
    ..OM-85, a detoxified immunoactive bacterial extract, has been shown to prevent recurrent exacerbations of bronchitis and COPD...
  14. ncbi CTLA4 gene polymorphisms are associated with chronic bronchitis
    G Zhu
    Glaxo SmithKline R and D, Research Triangle Park, NC 27709, USA
    Eur Respir J 34:598-604. 2009
    ..T-lymphocytes may play a key role in the pathogenesis of COPD and chronic bronchitis. Cytotoxic T-lymphocyte antigen (CTLA) 4 is a potential candidate gene because it modulates T-cell ..
  15. ncbi Direct medical costs of chronic obstructive pulmonary disease: chronic bronchitis and emphysema
    L Wilson
    Department of Clinical Pharmacy, School of Pharmacy, University of California, San Francisco 94143 0622, USA
    Respir Med 94:204-13. 2000
    ..we aimed to estimate direct medical costs of Chronic Obstructive Pulmonary Disease (COPD) by disease type; chronic bronchitis and emphysema...
  16. ncbi Interleukin-13 and -4 expression in the central airways of smokers with chronic bronchitis
    D Miotto
    Dept of Clinical and Experimental Medicine, University of Ferrara, Ferrara, Italy
    Eur Respir J 22:602-8. 2003
    ..T-helper 2-type cytokines interleukin (IL)-13 and -4 are involved in mucus hypersecretion, the hallmark of chronic bronchitis (CB)...
  17. ncbi Plasma cells and IL-4 in chronic bronchitis and chronic obstructive pulmonary disease
    Jie Zhu
    Lung Pathology Unit, Department of Gene Therapy, Imperial College London at the Royal Brompton Hospital, Sydney St, London SW3 6NP, UK
    Am J Respir Crit Care Med 175:1125-33. 2007
    ..Airway wall inflammation, IL-4, and mucus hypersecretion are thought to be associated...
  18. pmc Chlamydia pneumoniae and chronic bronchitis: association with severity and bacterial clearance following treatment
    F Blasi
    Institute of Respiratory Diseases, University of Milan, IRCCS Ospedale Maggiore di Milano, Milan, Italy
    Thorax 57:672-6. 2002
    ..pneumoniae chronic infection, other respiratory infections, and functional impairment in patients with chronic bronchitis (stage 1) and to examine chronic C pneumoniae infection, rate of acute exacerbations of chronic bronchitis, ..
  19. ncbi The diagnosis and treatment of elderly patients with acute exacerbation of chronic obstructive pulmonary disease and chronic bronchitis
    Timothy E Albertson
    Division of Pulmonary, Critical Care and Sleep Medicine, School of Medicine University of California at Davis, Sacramento, California, USA
    J Am Geriatr Soc 58:570-9. 2010
    The syndrome of chronic obstructive pulmonary disease (COPD) consists of chronic bronchitis (CB), bronchiectasis, emphysema, and reversible airway disease that combine uniquely in an individual patient...
  20. pmc Moxifloxacin in the management of exacerbations of chronic bronchitis and COPD
    Marc Miravitlles
    Servei de Pneumologia, Institut Clínic del Tòrax IDIBAPS, Hospital Clinic, Barcelona, Spain
    Int J Chron Obstruct Pulmon Dis 2:191-204. 2007
    Bacteria are isolated in more than 50% of exacerbations of chronic bronchitis (CB) and chronic obstructive pulmonary disease (COPD)...
  21. ncbi The role of Bordetella infections in patients with acute exacerbation of chronic bronchitis
    J Bonhoeffer
    University Children s Hospital Basel, P O Box, CH 4005 Basel, Switzerland
    Infection 33:13-7. 2005
    Acute exacerbations of chronic bronchitis (AECB) are associated with a variety of viral and bacterial infectious agents, some of which are potentially preventable by immunization...
  22. ncbi Vasoactive intestinal peptide receptors in the airways of smokers with chronic bronchitis
    D Miotto
    Dipartimento diMedicina Clinica e Sperimentale, Sezione di Igiene e Medicina del Lavoro, Via Fossato di Mortara 64 b, 44100 Ferrara, Italy
    Eur Respir J 24:958-63. 2004
    ..this study was to quantify the expression of both VPAC1R and VPAC2R in the central airways of smokers with chronic bronchitis. Surgical specimens were obtained from 33 smokers undergoing thoracotomy for localised pulmonary lesions: 23 ..
  23. ncbi Atopic diseases, allergic sensitization, and exposure to traffic-related air pollution in children
    Verena Morgenstern
    Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Institute of Epidemiology, Ingolstaedter Landstrasse 1, D 85764 Neuherberg, Germany
    Am J Respir Crit Care Med 177:1331-7. 2008
    ..In vitro studies, animal experiments, and human exposure studies have shown how ambient air pollution increases the risk of atopic diseases. However, results derived from observational studies are inconsistent...
  24. pmc Management of chronic obstructive pulmonary disease associated with chronic bronchitis with inhaled fluticasone propionate/salmeterol (ADVAIR DISKUS) 250/50: results of a patient experience trial
    Stuart Stoloff
    The University of Nevada School of Medicine, Reno, Nevada, USA
    MedGenMed 8:86. 2006
    ..Chronic obstructive pulmonary disease (COPD) is recognized as a major healthcare problem in the United States and around the world...
  25. ncbi Lung function decline, chronic bronchitis, and occupational exposures in young adults
    Jordi Sunyer
    Respiratory and Health Research Unit, Medical Research Institute, Barcelona, Spain
    Am J Respir Crit Care Med 172:1139-45. 2005
    ..Occupational exposures to vapors, gas, dust, or fumes have been shown to be a risk factor of airway obstruction in cross-sectional studies in the general population...
  26. ncbi Characterisation of exacerbations of chronic bronchitis and COPD in Europe: the GIANT study
    Marc Miravitlles
    Servei de Pneumologia Institut Clínic del Tòrax Hospital Clínic, Barcelona, Spain
    Ther Adv Respir Dis 3:267-77. 2009
    The GIANT study collected information on patients with acute exacerbations of chronic bronchitis (AECB) and chronic obstructive pulmonary disease (COPD) and the effect of treatment with moxifloxacin.
  27. ncbi Chronic cough due to chronic bronchitis: ACCP evidence-based clinical practice guidelines
    Sidney S Braman
    Division of Pulmonary and Critical Care Medicine, Rhode Island Hospital, 595 Eddy St, Providence, RI 02903, USA
    Chest 129:104S-115S. 2006
    b>Chronic bronchitis is a disease of the bronchi that is manifested by cough and sputum expectoration occurring on most days for at least 3 months of the year and for at least 2 consecutive years when other respiratory or cardiac causes for ..
  28. ncbi Association of symptoms of chronic bronchitis and frequent flu-like illnesses with stroke
    Armin J Grau
    Department of Neurology, Klinikum der Stadt Ludwigshafen a Rh, Germany
    Stroke 40:3206-10. 2009
    Acute and several chronic infectious diseases increase the risk of stroke. We tested the hypothesis that chronic bronchitis and frequent flu-like illnesses are independently associated with the risk of stroke or transient ischemic attack (..
  29. ncbi Chronic bronchitis and pesticide exposure: a case-control study in Lebanon
    Pascale R Salameh
    Faculty of Public Health, Lebanese University, Beirut, Lebanon
    Eur J Epidemiol 21:681-8. 2006
    Pesticides are widely used toxics. The objective of the study is to evaluate the odds of exposure to pesticides in chronic bronchitis patients.
  30. ncbi Association of snoring with chronic bronchitis
    Inkyung Baik
    Institute of Human Genomic Study, Korea University Ansan Hospital, 516 Gojandong Danwongu, Ansan 425 707, Korea
    Arch Intern Med 168:167-73. 2008
    Snoring is more prevalent in patients with chronic bronchitis than in persons without it. Few studies have examined the effect of snoring on chronic bronchitis...
  31. ncbi Chronic bronchitis in women using solid biomass fuel in rural Peshawar, Pakistan
    Tasleem Akhtar
    Pakistan Medical Research Council Research Center at Khyber Medical College, Peshawar NWFP 25000, Pakistan
    Chest 132:1472-5. 2007
    Biomass smoke has been associated with many diseases. The aim of this study was to evaluate the relationship between biomass smoke and chronic bronchitis in women in the rural setting of Peshawar, Pakistan.
  32. ncbi Should patients with acute exacerbation of chronic bronchitis be treated with antibiotics? Advantages of the use of fluoroquinolones
    J Mensa
    Infectious Diseases Unit, Hospital Clinic, University of Barcelona, Barcelona, Spain
    Clin Microbiol Infect 12:42-54. 2006
    The pathological changes in chronic bronchitis (CB) produce airflow obstruction, reduce the effectiveness of the mucocilliary drainage system and lead to bacterial colonisation of bronchial secretion...
  33. ncbi The workplace impact of acute exacerbations of chronic bronchitis (AECB); A literature review
    Michael T Halpern
    Exponent, Inc, Alexandria, Virginia, USA
    COPD 1:249-54. 2004
    Acute exacerbations of chronic bronchitis (AECB) are known to have a substantial economic burden in terms of medical care costs...
  34. ncbi Macrolide immunomodulatory effects and symptom resolution in acute exacerbation of chronic bronchitis and acute maxillary sinusitis: a focus on clarithromycin
    William R Bishai
    The Johns Hopkins University School of Medicine, Division of Infectious Diseases, Department of Medicine, 1550 Orleans Street, CRB2 108, Baltimore, MD 21231, USA
    Expert Rev Anti Infect Ther 4:405-16. 2006
    ..Macrolides have proven to be highly effective in treating acute bacterial exacerbations of chronic bronchitis and acute maxillary sinusitis...
  35. ncbi Indicators of bacterial infection in patients with acute exacerbation of chronic bronchitis for application in clinical trials of antibacterial drugs
    C J Burley
    Postgraduate Medical School, Manor Park, University of Surrey, Guildford, UK
    J Infect 55:226-32. 2007
    ..WBCs and <10 epithelial cells) and (c) microscopic examination of morphological bacterial cell types, in identifying bacterial infection in patients with an acute exacerbation of chronic bronchitis (AECB) for entry to clinical trials.
  36. ncbi Short-course therapy of acute bacterial exacerbation of chronic bronchitis: a double-blind, randomized, multicenter comparison of extended-release versus immediate-release clarithromycin
    Piotr Nalepa
    Krakow, Poland
    Curr Med Res Opin 19:411-20. 2003
    The objective of this study was to compare the efficacy and safety of two clarithromycin formulations given for 5 days to patients with acute bacterial exacerbation of chronic bronchitis (ABECB).
  37. ncbi Role of oral extended-spectrum cephems in the treatment of acute exacerbation of chronic bronchitis
    Antonio Anzueto
    University of Texas Health Science Center, South Texas Veterans Healthcare System, San Antonio, TX 78284, USA
    Diagn Microbiol Infect Dis 57:31S-38S. 2007
    Risk stratification is the recommended approach for treatment of acute exacerbation of chronic bronchitis (AECB) to optimize the chances of clinical success...
  38. ncbi Acute exacerbation of chronic bronchitis: need for an evidence-based approach
    Claudio F Donner
    Division of Pulmonary Disease, Fondazione Salvatore Maugeri IRCCS, Scientific Institute of Veruno, Veruno NO, Italy
    Pulm Pharmacol Ther 19:4-10. 2006
    Acute exacerbations of chronic bronchitis (AECB) can be classified into three levels according to severity: (1) home treatment sufficient; (2) hospitalisation required; (3) hospitalisation in the presence of respiratory failure...
  39. ncbi FAB-MS characterization of sialyl Lewis x determinants on polylactosamine chains of human airway mucins secreted by patients suffering from cystic fibrosis or chronic bronchitis
    W Morelle
    Department of Biological Sciences, Imperial College of Science, Technology and Medicine, London, SW7 2AY, UK
    Glycoconj J 18:699-708. 2001
    Although a large body of structural data exists for bronchial mucins from cystic fibrosis (CF) and chronic bronchitis (CB) patients, little is known about terminal structures carried on poly-N-acetyllactosamine antennae...
  40. ncbi Open-label, randomized comparison of the efficacy and tolerability of clarithromycin, levofloxacin, and cefuroxime axetil in the treatment of adults with acute bacterial exacerbations of chronic bronchitis
    Lee R Weiss
    Department of Emergency Medicine, Knox Community Hospital, Mount Vernon, Ohio 43050, USA
    Clin Ther 24:1414-25. 2002
    ..the absence of a confirmed pathogen, empiric antimicrobial treatment of patients with acute exacerbations of chronic bronchitis and acute bacterial exacerbations of chronic bronchitis (ABECB) is accepted as standard practice and ..
  41. ncbi [An experimental study on airway inflammation and remodeling in a rat model of chronic bronchitis and emphysema]
    Xiao Ning Zhong
    Department of Respiratory Diseases, First Affiliated Hospital of Guangxi Medical University, Nanning 530021, China
    Zhonghua Jie He He Hu Xi Za Zhi 26:750-5. 2003
    To study the pathological features of airway inflammation and remodeling in rats with chronic bronchitis (CB) and emphysema and to evaluate the protective and therapeutic effects of erythromycin (EM).
  42. ncbi Anti-oxidative effect of triterpene acids of Eriobotrya japonica (Thunb.) Lindl. leaf in chronic bronchitis rats
    Yan Huang
    School of Pharmacy, Anhui Medical University, Hefei, Anhui Province, China 230032
    Life Sci 78:2749-57. 2006
    ..Lindl. leaf (TAL) on expression of antioxidative mediators by alveolar macrophages (AM) in rats with chronic bronchitis (CB), CB was induced by endotracheal instillation of lipopolysaccharedes (LPS) followed by Bacillus Calmette-..
  43. ncbi Chronic exposure to volcanic environments and chronic bronchitis incidence in the Azores, Portugal
    André Filipe Santos Amaral
    Department of Biology, University of the Azores, R Mae de Deus, APT 1422, 9501 855 Ponta Delgada, Portugal
    Environ Res 103:419-23. 2007
    ..to investigate the existence of a possible association between chronic exposure to volcanic sulfur gases and chronic bronchitis. To investigate this, we used two populations, one exposed to active manifestations of volcanism (Furnas) ..
  44. ncbi Canadian guidelines for the management of acute exacerbations of chronic bronchitis
    Meyer S Balter
    University of Toronto, Mount Sinai Hospital, Toronto, Canada
    Can Respir J 10:3B-32B. 2003
    Acute exacerbations of chronic bronchitis (AECB) account for over 1.5 million physician visits annually in Canada and are a cause of significant morbidity and mortality...
  45. ncbi Development of a quantifiable symptom assessment tool for patients with chronic bronchitis: the Chronic Bronchitis Symptoms Assessment Scale
    David H Au
    Health Services Research and Development, VA Puget Sound Health Care System, 1660 S Columbian Way, Seattle, Washington 98108, USA
    COPD 2:209-16. 2005
    ..an instrument to reliably assess symptom severity and frequency in therapeutic trials for patients with chronic bronchitis. We performed a series of psychometric studies that determined instrument content and assessed validity and ..
  46. ncbi Solutions for difficult diagnostic cases of acute exacerbations of chronic bronchitis
    K W Tsang
    Division of Respiratory and Critical Care Medicine, Department of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong, China
    Chemotherapy 47:28-38; discussion 53-4. 2001
    Acute exacerbation of chronic bronchitis (AECB) is a very common condition, which presents with deteriorating sputum production and dyspnoea in a patient with pre-existing COPD or chronic bronchitis...
  47. ncbi [Effect of occupational exposure and smoking on spirometric tests and symptoms of chronic bronchitis]
    Tomasz Kachel
    Oddziału Pulmonologiczno Alergologicznego Specjalistycznego Zespołu, Chorób Płuc i Gruźlicy w Bystrej Saskiej
    Pneumonol Alergol Pol 71:428-39. 2003
    ..2 years. In all cases concentrations of noxious agents did not exceed allowed levels. The symptoms of chronic bronchitis (cough and phlegm) were present in 12.3% and airflow limitation (FEV1% FVC < 0.7) in 6.9% of subjects...
  48. ncbi Healthy worker effect in cohort studies on chronic bronchitis
    Katja Radon
    Department of Medicine, Joint Departments of Epidemiology and Biostatistics and Occupational Health, McGill University, Montreal, Quebec, Canada
    Scand J Work Environ Health 28:328-32. 2002
    ..The aim of the present paper was to estimate the magnitude of the healthy worker survivor effect in cohort studies of symptoms of chronic bronchitis.
  49. ncbi Macrolides, quinolones and amoxicillin/clavulanate for chronic bronchitis: a meta-analysis
    I I Siempos
    Alfa Institute of Biomedical Sciences AIBS, 9 Neapoleos Street, 151 23 Marousi, Athens, Greece
    Eur Respir J 29:1127-37. 2007
    ..and amoxicillin/clavulanate (A/C) for the treatment of patients with acute bacterial exacerbation of chronic bronchitis (ABECB) was evaluated in the present study...
  50. pmc Gemifloxacin use in the treatment of acute bacterial exacerbation of chronic bronchitis
    Cristian Jivcu
    Department of Internal Medicine, Banner Good Samaritan Medical Center, Phoenix, AZ, USA
    Int J Chron Obstruct Pulmon Dis 4:291-300. 2009
    ..of fluoroquinolones have proven efficacy against bacterial organisms associated with acute exacerbation of chronic bronchitis (AECB)...
  51. ncbi Interleukin-4 and interleukin-5 gene expression and inflammation in the mucus-secreting glands and subepithelial tissue of smokers with chronic bronchitis. Lack of relationship with CD8(+) cells
    J Zhu
    Department of Gene Therapy, Imperial College School of Medicine, London, United Kingdom
    Am J Respir Crit Care Med 164:2220-8. 2001
    We wished to determine if the inflammatory cells surrounding the airway mucus-secreting glands in chronic bronchitis (CB) were associated with interleukin (IL)-4 and IL-5 mRNA expression and whether the CD8 T cell population expressed ..
  52. ncbi The association between home and vehicle environmental tobacco smoke (ETS) and chronic bronchitis in a Canadian population: the Canadian Community Health Survey, 2005
    Jessica Evans
    Department of Epidemiology and Community Medicine, University of Ottawa, 451 Smyth Road, Ottawa, Ontario, Canada
    Inhal Toxicol 21:244-9. 2009
    ..to determine the association between home and vehicle exposure to environmental tobacco smoke (ETS), and chronic bronchitis based on data from 64,961 non-smokers aged 12 years and older who participated in the 2005 Canadian ..
  53. pmc Treating acute exacerbations of chronic bronchitis and community-acquired pneumonia: how effective are respiratory fluoroquinolones?
    M Balter
    Mount Sinai Hospital, Toronto, Ontario, Canada
    Can Fam Physician 52:1236-42. 2006
    To provide family physicians with a review of evidence supporting fluoroquinolone therapy for defined patient populations with acute exacerbations of chronic bronchitis (AECB) and community-acquired pneumonia (CAP).
  54. ncbi Twins studies as a model for studies on the interaction between smoking and genetic factors in the development of chronic bronchitis
    Magnus Svartengren
    Department of Public Health Science, Karolinska Institutet at Norrbacka, SE 171 76 Stockholm, Sweden
    Biochem Soc Trans 37:814-8. 2009
    ..Disease was defined as self-reported chronic bronchitis or emphysema, or recurrent cough with phlegm...
  55. ncbi The relation of body mass index to asthma, chronic bronchitis, and emphysema
    Stefano Guerra
    Arizona Respiratory Center, College of Medicine, University of Arizona, 1501 N Campbell Avenue, Tucson, AZ 85724 5030, USA
    Chest 122:1256-63. 2002
    ..Recent studies have suggested a relationship between asthma and obesity. Despite these reports, the effect of being underweight or overweight as a risk factor for airway obstructive diseases (AODs) is not clear...
  56. ncbi Health-related QOL in acute exacerbations of chronic bronchitis and chronic obstructive pulmonary disease: a review of the literature
    Helen Doll
    Oxford Outcomes, Old Barn, Jericho Farm, Cassington, Oxford, UK
    Pharmacoeconomics 23:345-63. 2005
    There is a lack of emphasis on health-related QOL (HR-QOL) changes associated with acute exacerbation of chronic bronchitis (CB) or chronic obstructive pulmonary disease (COPD)...
  57. pmc Mortality in GOLD stages of COPD and its dependence on symptoms of chronic bronchitis
    Marie Ekberg-Aronsson
    Department of Respiratory Medicine and Allergology, University of Lund, S 221 85 Lund, Sweden
    Respir Res 6:98. 2005
    ..The aims of this study were to investigate total mortality risks in GOLD stages 0-4 with special focus on stage 0, and furthermore to assess the influence of symptoms of chronic bronchitis on mortality risks in GOLD stages 1-4.
  58. ncbi The economic impact of acute exacerbations of chronic bronchitis in the United States and Canada: a literature review
    Michael T Halpern
    Exponent Inc, Alexandria, VA 22314, USA
    J Manag Care Pharm 9:353-9. 2003
    Acute exacerbations of chronic bronchitis (AECB) are recurrent and potentially severe medical events for the 13 million people in the United States who have chronic bronchitis...
  59. pmc Interaction of atopy and smoking on respiratory effects of occupational dust exposure: a general population-based study
    Gea de Meer
    Institute for Risk Assessment Science, Div, Environmental and Occupational Health, Utrecht University, P, O, Box 80176, 3508 TD Utrecht, The Netherlands
    Environ Health 3:6. 2004
    ..Assess relationship between airway obstruction and occupational exposure using a job-exposure-matrix (JEM) classifying jobs into 3 broad types of exposure, and test for effect modification by atopy, and smoking...
  60. ncbi Predictors of influenza vaccination in adults with chronic bronchitis
    Rodrigo Jimenez-Garcia
    Unidad de Docencia e Investigacion en Medicina Preventiva y Salud Publica, Facultad de Ciencias de la Salud, Avda de Atenas s n, 28402 Alcorcón, Madrid, Spain
    Respir Med 103:1518-25. 2009
    Influenza vaccination is recommended for people with chronic bronchitis (CB) because they have a higher risk of influenza-related complications, hospitalizations, and death during seasonal influenza epidemics...
  61. ncbi Nontypeable Haemophilus influenzae in the lower respiratory tract of patients with chronic bronchitis
    V Bandi
    Department of Medicine, Baylor College of Medicine, Houston, Texas 77030, USA
    Am J Respir Crit Care Med 164:2114-9. 2001
    ..in the lower respiratory tract was determined in healthy adults and in clinically stable and acutely ill chronic bronchitis (CB) patients...
  62. ncbi [Bacterial etiology of chronic bronchitis exacerbations treated by primary care physicians]
    Carles Llor
    Centro de Salud Jaume I, Tarragona, Espana
    Arch Bronconeumol 42:388-93. 2006
    Few studies have been carried out to determine the prevalence of microorganisms causing exacerbations of chronic bronchitis in the community setting...
  63. pmc Traffic-related air pollution associated with prevalence of asthma and COPD/chronic bronchitis. A cross-sectional study in Southern Sweden
    Anna Lindgren
    Department of Occupational and Environmental Medicine, Lund University, Lund, Sweden
    Int J Health Geogr 8:2. 2009
    ..A Geographical Information System (GIS) was used to link geocoded residential addresses to a Swedish road database and an emission database for NOx...
  64. pmc Chronic bronchitis among nonsmoking farm women in the agricultural health study
    Martin Valcin
    Epidemiology, National Institute of Environmental Health Sciences, NIH, DHHS, Research Triangle Park, NC 27709 2233, USA
    J Occup Environ Med 49:574-83. 2007
    The purpose of this study was to examine agricultural risk factors for chronic bronchitis among nonsmoking farm women.
  65. ncbi Appropriateness of antibiotic prescribing in veterans with community-acquired pneumonia, sinusitis, or acute exacerbations of chronic bronchitis: a cross-sectional study
    Colleen Cook Tobia
    Department of Pharmacy, Veterans Affairs Pittsburgh Healthcare System, School of Pharmacy, University of Pittsburgh, Pittsburgh, Pennsylvania 15240 1000, USA
    Clin Ther 30:1135-44. 2008
    ....
  66. ncbi Intrapulmonary pharmacodynamics of high-dose levofloxacin in subjects with chronic bronchitis or chronic obstructive pulmonary disease
    John E Conte
    Infectious Diseases Research Group, Department of Epidemiology and Biostatistics, University of California at San Francisco, 901F Health Sciences East, 513 Parnassus Avenue, San Francisco, CA 94143 0919, USA
    Int J Antimicrob Agents 30:422-7. 2007
    ....
  67. ncbi Variables associated with recovery from acute exacerbations of chronic bronchitis and chronic obstructive pulmonary disease
    Marc Miravitlles
    Pneumology Department, Institut Clínic del Tòrax IDIBAPS, Red Respira FIS ISCIII RTIC 03 11, Hospital Clinic, Villarroel 170, 08036 Barcelona, Catalonia, Spain
    Respir Med 99:955-65. 2005
    To identify risk factors for late recovery and failure after ambulatory treatment of exacerbations of chronic bronchitis (CB) and chronic obstructive pulmonary disease (COPD).
  68. ncbi How accurate is the self-reported diagnosis of chronic bronchitis?
    Arnel Bobadilla
    Arizona Respiratory Center, University of Arizona, 1501 N Campbell Avenue, Tucson, AZ 85724 5030, USA
    Chest 122:1234-9. 2002
    ..for at least 3 months per year for at least 2 consecutive years, difficulties exist in the use of the term chronic bronchitis for clinical diagnosis...
  69. ncbi Reported prevalence and co-morbidity of asthma, chronic bronchitis and emphysema: a pan-European estimation
    S Boutin-Forzano
    Epidemiology of Allergic and Respiratory Diseases, Unité Mixte de Recherche en Santé 707, Institut National de la Sante et de la Recherche Medicale, Paris, France
    Int J Tuberc Lung Dis 11:695-702. 2007
    ..Study conducted in random samples from eight European cities were used 1) to describe the prevalence of chronic bronchitis and emphysema (CBE) and asthma according to socio-demography, addictions, physical activities and body mass ..
  70. ncbi Antibiotics in acute exacerbations of chronic bronchitis
    Sanjay Sethi
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, University at Buffalo SUNY Buffalo, NY, USA
    Expert Rev Anti Infect Ther 8:405-17. 2010
    Acute exacerbations of chronic bronchitis (AECB) are a major contributor to morbidity and mortality in patients with chronic obstructive pulmonary disease, accounting for more than 16 million physician office visits and over 500,000 ..
  71. ncbi Optimizing ceftazidime pharmacodynamics in patients with acute exacerbation of severe chronic bronchitis
    Annette Lubasch
    Zentralklinik Emil v Behring, Department Lungenklinik Heckeshorn, Pneumologie I, Freie Universitat Berlin, Zum Heckeshorn 33, D 14109 Berlin
    J Antimicrob Chemother 51:659-64. 2003
    ..study, we evaluated the clinical and bacteriological outcome and pharmacokinetic as well as pharmacodynamic parameters of two ceftazidime therapy regimens in patients with acute exacerbation of severe chronic bronchitis (AECB).
  72. ncbi [Malnutrition in children with chronic bronchitis]
    S Viola
    Service de gastroentérologie et nutrition pédiatrique, Hopital Armand Trousseau, Universite Pierre et Marie Curie Paris 6, Assistance Publique Hopitaux de Paris, 26 avenue du Docteur Arnold Netter, Paris, France
    Arch Pediatr 15:1270-5. 2008
    To study nutritional status in children with chronic bronchitis (CB) in relation with lung function.
  73. pmc Effect of sputum processing with dithiothreitol on the detection of inflammatory mediators in chronic bronchitis and bronchiectasis
    I S Woolhouse
    Department of Medicine, Queen Elizabeth Hospital, Birmingham, UK
    Thorax 57:667-71. 2002
    ..to assess airway inflammation in patients with chronic obstructive pulmonary disease, including those with chronic bronchitis and bronchiectasis...
  74. ncbi Short-course antibiotic treatment in acute exacerbations of chronic bronchitis and COPD: a meta-analysis of double-blind studies
    R El Moussaoui
    Department of Internal Medicine, Division of Infectious Diseases, Tropical Medicine and AIDS and Center for Infection and Immunity Amsterdam CINIMA, Amsterdam, The Netherlands
    Thorax 63:415-22. 2008
    ..undertaken to determine whether a short course of antibiotic treatment (< or = 5 days) is as effective as the conventional longer treatment in acute exacerbations of chronic bronchitis and chronic obstructive pulmonary disease (COPD).
  75. pmc Leisure time physical activity and disease-specific mortality among men with chronic bronchitis: evidence from the Whitehall study
    G David Batty
    Epidemiology Unit, Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, England
    Am J Public Health 93:817-21. 2003
    This study examined the association between leisure time physical activity and cause-specific mortality among male Whitehall Study participants with chronic bronchitis.
  76. ncbi American Thoracic Society Statement: Occupational contribution to the burden of airway disease
    John Balmes
    Am J Respir Crit Care Med 167:787-97. 2003
  77. ncbi Serum surfactant protein-A levels in chronic bronchitis and its relation to smoking
    D Behera
    Department of Pulmonary Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, India
    Indian J Chest Dis Allied Sci 47:13-7. 2005
    ..Little is known on the SP-A levels in patients with chronic obstructive pulmonary disease (COPD)...
  78. ncbi Acute exacerbations of chronic bronchitis: new developments concerning microbiology and pathophysiology--impact on approaches to risk stratification and therapy
    Sanjay Sethi
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, University at Buffalo SUNY, Buffalo, NY 14260, USA
    Infect Dis Clin North Am 18:861-82, ix. 2004
    ..This article discusses a rational, stratified approach to the use of antibiotics for this condition based on these recent studies...
  79. ncbi Risk of depression and anxiety in employees with chronic bronchitis: the modifying effect of cigarette smoking
    Edwin J Wagena
    Department of General Practice, Care and Public Health Research Institute, Maastricht University, Maastricht, The Netherlands
    Psychosom Med 66:729-34. 2004
    The present study evaluates whether smoking status modifies the association between chronic bronchitis and depression or anxiety in a population-based sample...
  80. pmc Prulifloxacin: a brief review of its potential in the treatment of acute exacerbation of chronic bronchitis
    Francesco Blasi
    Institute of Respiratory Diseases, University of Milan, Fondazione IRCCS Policlinico Mangiagalli Regina Elena, Milano, Italy
    Int J Chron Obstruct Pulmon Dis 2:27-31. 2007
    Exacerbations of chronic bronchitis (AECB) are a major cause of morbidity and mortality in patients with chronic obstructive pulmonary disease (COPD), and their impact on public health is increasing...
  81. ncbi Short- versus long-duration antimicrobial treatment for exacerbations of chronic bronchitis: a meta-analysis
    Matthew E Falagas
    Alfa Institute of Biomedical Sciences AIBS, Athens, Greece
    J Antimicrob Chemother 62:442-50. 2008
    The aim of this study was to evaluate the comparative effectiveness and safety of short (5 days) and long (7 or 10 days) duration antimicrobial treatment of patients with acute exacerbations of chronic bronchitis (AECB).
  82. pmc Comparison between various indices of exposure to traffic-related air pollution and their impact on respiratory health in adults
    G Cesaroni
    Epidemiology Department, Local Health Unit, ASL RME, Via S Costanza 53, 00198 Rome, Italy
    Occup Environ Med 65:683-90. 2008
    ....
  83. ncbi Prospective observational study of patient-reported outcomes for azithromycin versus usual care in the treatment of bacterial acute exacerbation of chronic bronchitis
    Aaron Milstone
    Pulmonary Division, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Clin Ther 27:926-39. 2005
    ..The 3-day course of azithromycin (AZM) 500 mg/d was introduced to the US market in June 2002...
  84. ncbi Smoking: relationship to chronic bronchitis, chronic obstructive pulmonary disease and mortality
    Margit Pelkonen
    Department of Pulmonary Diseases, Kuopio University Hospital, Kuopio, Finland
    Curr Opin Pulm Med 14:105-9. 2008
    To describe the recent findings concerning the relationship between smoking, chronic bronchitis, chronic obstructive pulmonary disease and mortality.
  85. ncbi Specific nasal symptoms and symptom-provoking factors may predict increased risk of developing COPD
    Ulf Nihlen
    Respiratory Medicine and Allergology, Lund University Hospital, Lund, Sweden
    Clin Physiol Funct Imaging 28:240-50. 2008
    ..that certain nasal symptoms and symptom-provoking factors were associated with prevalence of self-reported chronic bronchitis/emphysema (CBE)...
  86. ncbi Appropriate outpatient treatment of acute bacterial exacerbations of chronic bronchitis
    Fernando J Martinez
    University of Michigan Health System, Ann Arbor, Michigan, USA
    Am J Med 118:39S-44S. 2005
    Acute exacerbations of chronic bronchitis (AECB), which are characteristic of chronic obstructive pulmonary disease (COPD), contribute to morbidity and decreased quality of life for patients with COPD...
  87. ncbi Pneumocystis jiroveci isolates with dihydropteroate synthase mutations in patients with chronic bronchitis
    E Calderon
    Department of Internal Medicine, Virgen del Rocio University Hospital, Seville, Spain
    Eur J Clin Microbiol Infect Dis 23:545-9. 2004
    ..jiroveci DHPS mutations in patients with chronic bronchitis. P...
  88. ncbi Relationship of airway epithelial ion transport to chronic bronchitis
    Richard C Boucher
    Cystic Fibrosis Pulmonary Research and Treatment Center, University of North Carolina at Chapel Hill, CB number 7248, 7011 Thurston Bowles, Chapel Hill, NC 27599 7248, USA
    Proc Am Thorac Soc 1:66-70. 2004
    Failure to clear mucus normally is a critical event in the pathogenesis of chronic bronchitis (CB)...
  89. ncbi Comparison of first-line with second-line antibiotics for acute exacerbations of chronic bronchitis: a metaanalysis of randomized controlled trials
    George Dimopoulos
    Alfa Institute of Biomedical Sciences AIBS, 9 Neapoleos St, 151 23 Marousi, Greece
    Chest 132:447-55. 2007
    Although acute exacerbations of chronic bronchitis (AECBs) are common, there has been no metaanalysis that focused on the optimum regimen.
  90. ncbi Imaging of the patient with chronic bronchitis: an overview of old and new signs
    M Zompatori
    Dipartimento di Scienze Cliniche, Sezione di Diagnostica per Immagini, Universita di Parma, Parma, Italy
    Radiol Med 111:634-9. 2006
    ..nor high-resolution computed tomography (HRCT) has much to offer to the diagnosis of patients with chronic bronchitis (CB). A lot of HRCT findings can be observed, but they cannot be regarded as specific for pure CB...
  91. ncbi Economic evaluation of the antibiotic treatment of exacerbations of chronic bronchitis and COPD in primary care
    C Llor
    Infectious Diseases Group of the Catalan Society of Family Medicine, Barcelona, Spain
    Int J Clin Pract 58:937-44. 2004
    ..to assess the effectiveness and direct medical costs derived from antibiotic treatment of exacerbations of chronic bronchitis (CB) and chronic obstructive pulmonary disease (COPD) in primary care...
  92. pmc Chronic bronchitis and urban air pollution in an international study
    J Sunyer
    Centre de Recerca en Epidemiologia Ambiental, Institut Municipal Investigacio Medica, Barcelona, Spain
    Occup Environ Med 63:836-43. 2006
    The chronic effects of urban air pollution are not well known. The authors' aim was to investigate the association between the prevalence and new onset of chronic bronchitis and urban air pollution.
  93. pmc Clinical and bacteriological efficacy in treatment of acute exacerbations of chronic bronchitis with cefditoren-pivoxil versus cefuroxime-axetil
    Jose Luis Alvarez-Sala
    Microbiology Department, School of Medicine, Universidad Complutense, Avda Complutense s n, 28040 Madrid, Spain
    Antimicrob Agents Chemother 50:1762-7. 2006
    ..treatment (250 mg twice daily for 10 days) of Anthonisen type I or II acute exacerbations of chronic bronchitis. The modified intention-to-treat population included 541 patients...
  94. ncbi Clinical efficacy of OM-85 BV in COPD and chronic bronchitis: a systematic review
    Mark D Sprenkle
    Division of Pulmonary and Critical Care Medicine, Hennepin County Medical Center, Pulmonary Medicine 865B, 701 Park Ave, Minneapolis, Minnesota 55415, USA
    COPD 2:167-75. 2005
    ..Studies were included if they involved persons with chronic obstructive pulmonary disease or chronic bronchitis and were randomized to OM-85 BV or placebo...
  95. pmc Antibiotic treatment and factors influencing short and long term outcomes of acute exacerbations of chronic bronchitis
    R Wilson
    Royal Brompton Hospital, Sydney Street, London SW3 6NP, UK
    Thorax 61:337-42. 2006
    ..with three standard antibiotic regimens in patients with Anthonisen type 1 acute exacerbations of chronic bronchitis (AECB)...
  96. ncbi Study entry microbiology in patients with acute bacterial exacerbation of chronic bronchitis in a clinical trial stratifying by disease severity
    James B Kahn
    PriCara, Unit of Ortho McNeil, Inc, Raritan, NJ 08869, USA
    Curr Med Res Opin 23:1-7. 2007
    To examine study entry microbiology in patients stratified by disease severity in a clinical trial in acute bacterial exacerbation of chronic bronchitis (ABECB).
  97. ncbi Effect of salmeterol on mucociliary and cough clearance in chronic bronchitis
    William D Bennett
    Center for Environmental Medicine, Asthma and Lung Biology, University of North Carolina at Chapel Hill, 27599, USA
    Pulm Pharmacol Ther 19:96-100. 2006
    The effect of long acting beta(2)-adrenergic bronchodilators on impaired mucociliary clearance in chronic bronchitis is unknown...
  98. ncbi Prulifloxacin: a new fluoroquinolone for the treatment of acute exacerbation of chronic bronchitis
    Mario Cazzola
    Department of Pneumology, Unit of Pneumology and Allergology, A Cardarelli Hospital, Via del Parco Margherita 24, 80121 Naples, Italy
    Pulm Pharmacol Ther 19:30-7. 2006
    Empiric therapy with oral antibiotics is normal practice in the treatment of acute exacerbations of chronic bronchitis (AECB), but there is growing concern regarding efficacy of the currently available antimicrobials...
  99. ncbi A review of guidelines for antibacterial use in acute exacerbations of chronic bronchitis
    Francesco Blasi
    Pad LITTA, IRCCS Ospedale Maggiore Policlinico, Via F Sforza, 35, 20122, University of Milan, Policlinico, Milan, Italy
    Pulm Pharmacol Ther 19:361-9. 2006
    Acute exacerbations of chronic bronchitis (AECB) affect a significant proportion of the adult population worldwide and are associated with a substantial socioeconomic burden...
  100. ncbi Acute exacerbation of chronic bronchitis: a primary care consensus guideline
    Stephen Brunton
    Department of Family Medicine, University of California, Irvine, Calif, USA
    Am J Manag Care 10:689-96. 2004
    To develop consensus on appropriate treatment for acute exacerbation of chronic bronchitis (AECB)...
  101. ncbi Five-day moxifloxacin therapy compared with 7-day co-amoxiclav therapy for the treatment of acute exacerbation of chronic bronchitis
    I Starakis
    Department of Internal Medicine, Infectious Diseases Section, University Hospital, 26500 Rion Patras, Greece
    Int J Antimicrob Agents 23:129-37. 2004
    ..that of co-amoxiclav (one 625 mg tablet every 8h) for 7 days, for the treatment of acute exacerbations of chronic bronchitis (AECB)...

Research Grants63

  1. EPITHELIAL CELL RESPONSE TO H.INFLUENZAE IN THE AIRWAY
    Dwight Look; Fiscal Year: 2003
    ..human respiratory mucosa and often produces respiratory tract disease, particularly in patients with chronic bronchitis, bronchiectasis, and cystic fibrosis...
  2. BIOSYNTHESIS OF TRACHEAL MUCOUS GLYCOPROTEINS
    Pi Wan Cheng; Fiscal Year: 2010
    Mucus hypersecretion is a hallmark of obstructive lung diseases, including chronic bronchitis, asthma, and cystic fibrosis. This condition is the result of hypertrophy and hyperplasia of mucus cells...
  3. Neurotrophins in the Lung
    Y S Prakash; Fiscal Year: 2012
    ..airway narrowing and accompanying shortness of breath in clinically important diseases such as asthma and chronic bronchitis. In this regard, the potential role of growth factors called neurotrophins in regulation of airway ..
  4. ROLE OF SIRTUIN IN CIGARETTE SMOKE-INDUCED LUNG INFLAMMATION AND INJURY
    Irfan Rahman; Fiscal Year: 2013
    ..COPD (emphysema and chronic bronchitis) is linked with premature aging (accelerated decline in lung function) and chronic inflammation of the lungs ..
  5. Mechanism Underlying Nitrite Sensitivity of Mucoid Pseudomonas in COPD
    Daniel J Hassett; Fiscal Year: 2013
    ..HEALTH RELEVANCE: Chronic obstructive pulmonary disease (COPD) is a debilitating lung disorder encompassing chronic bronchitis and/or emphysema, and characterized by nonreversible airflow limitation...
  6. Anti-Bacterial Innate Responses Enhance Paramyxovirus Replication
    Griffith D Parks; Fiscal Year: 2010
    ..infections involving bacteria and paramyxoviruses are a significant factor in human patients with chronic bronchitis, sinusitis and otitis media...
  7. Iowa Phase II Clinical Trials of Novel Therapies for Lung Diseases (U01
    Lakshmi Durairaj; Fiscal Year: 2012
    ..a cheap and effective intervention for several conditions in addition to CF, such as non-CF bronchiectasis, chronic bronchitis and ventilator associated pneumonia...
  8. Development of Bioactive Chemical Probes for Calcium-activated Chloride Channel
    Min Li; Fiscal Year: 2012
    ..Abnormality of CaCC is thought to be causal to diseases, such as cystic fibrosis, asthma, chronic bronchitis, and hypertension...
  9. MNEI/SerpinB1: A modulator of innate pulmonary defense
    EILEEN REMOLD-O'DONNELL; Fiscal Year: 2010
    ..which an aggressive host response leads to lung injury as occurs in patients with cystic fibrosis and COPD (chronic bronchitis, emphysema) will provide understanding that may lead to improved treatment...
  10. Mechanisms of oxidant-induced chronic bronchitis
    ROSANNA C MALBRAN FORTEZA; Fiscal Year: 2012
    ..is to understand the cellular and molecular mechanisms that lead to the structural changes associated with chronic bronchitis. This application continues our focus on oxidative stress-induced EGFR activation and mucus hypersecretion...
  11. Abnormality in Gene Expression of Key Mediators of Vitamin A Action in COPD
    Salil K Das; Fiscal Year: 2010
    b>Chronic bronchitis and emphysema are two kinds of chronic obstructive pulmonary disease (COPD), which are important causes of morbidity and mortality in the United States...
  12. Developing Nrf2 as a target for treatment of corticosteroid resistance in COPD
    Robert A Wise; Fiscal Year: 2012
    ..Abnormal airway inflammation is thought to contribute to chronic bronchitis, small-airway obstruction and emphysema...
  13. Spinal Cord-Mediated Acute Neurogenic Inflammation
    Qing Lin; Fiscal Year: 2010
    ..contributes to many clinically relevant states, including arthritis, inflammatory bowel disease, chronic bronchitis, migraine and interstitial cystitis...
  14. BIOLOGY OF SUBMUCOSAL GLAND STEM CELLS IN THE AIRWAY
    John F Engelhardt; Fiscal Year: 2013
    ..In diseases such as cystic fibrosis (CF), asthma, and chronic bronchitis, Submucosal glands expand in mass (hypertrophy) and/or abundance (hyperplasia), leading to excessive and ..
  15. Pulmonary Vasoreactivity Following Chronic Hypoxia
    Thomas C Resta; Fiscal Year: 2012
    ..PUBLIC HEALTH RELEVANCE: Chronic obstructive pulmonary diseases (COPD) such as emphysema and chronic bronchitis are established major causes of mortality and morbidity in the U.S...
  16. Role of the Aryl Hydrocarbon Receptor in Lung Inflammation
    PATRICIA JANET SIME; Fiscal Year: 2012
    ..cigarette smoke is the primary cause of chronic obstructive pulmonary disease (COPD-emphysema and chronic bronchitis)...
  17. Airway epithelial repair in chronic bronchitis: novel signaling mechanisms
    Andreas Schmid; Fiscal Year: 2013
    ..Chronic inflammatory airway diseases, including smoking-induced chronic bronchitis, lead to damage of the airway epithelium with subsequent impairment of mucociliary clearance, a condition ..
  18. Airway epithelial repair in chronic bronchitis: novel signaling mechanisms
    Andreas Schmid; Fiscal Year: 2011
    ..Chronic inflammatory airway diseases, including smoking-induced chronic bronchitis, lead to damage of the airway epithelium with subsequent impairment of mucociliary clearance, a condition ..
  19. Signaling Sphingolipids in COPD
    Irina Petrache; Fiscal Year: 2009
    ..End of Abstract) PUBLIC HEALTH RELEVANCE: PROJECT NARRATIVE Pulmonary emphysema and chronic bronchitis comprise the spectrum of COPD, a prevalent fatal disease...
  20. The Role of Caveolins in Lung Inflammation
    CHRISTINA MARIA PABELICK; Fiscal Year: 2013
    ..airway narrowing and accompanying shortness of breath in clinically- important diseases such as asthma and chronic bronchitis. In this regard, the potential role of cellular structures called caveolae and their constituent caveolin ..
  21. Calcium Regulation in Airway Smooth Muscle
    Gary C Sieck; Fiscal Year: 2013
    ..airway narrowing and accompanying shortness of breath in clinically-important diseases such as asthma and chronic bronchitis. Airway contractility is highly dependent on intracellular calcium levels...
  22. GST alleles and oxidant pollutants in the pathogenesis of asthma
    Beverly H Koller; Fiscal Year: 2010
    ..support a role for polymorphism in this gene family in determination of risk of developing asthma, COPD, chronic bronchitis and occupational lung disease...
  23. Pathogenic Mechanism for Lung Infection in Mucoid Pseudomonas
    DENNIS EDWARD OHMAN; Fiscal Year: 2013
    ..This can occur as a complication of emphysema, chronic bronchitis, cancer and immunosuppressive drug therapy...
  24. Molecular Genetics of Pathogen Recognition Receptors in COPD
    Tricia D LeVan; Fiscal Year: 2013
    ..bind Gram (+) and Gram (-) bacterial components, as well as fungal components, are associated with COPD, chronic bronchitis symptoms and/or lung function;and to determine whether there is an association of these polymorphisms with ..
  25. Resolution of Epithelial Cell Hyperplasia
    Yohannes Tesfaigzi; Fiscal Year: 2013
    ..MCM is one of the major factors for increased mucous hypersecretion in chronic bronchitis. We have shown that Bcl-2, an inhibitor of apoptosis, sustains MCM in rats and mice and may have clinical ..
  26. Molecular Pathways Regulating Airway Goblet Cell Mucin Secretion
    Burton F Dickey; Fiscal Year: 2013
    ..substantially increases patient morbidity and mortality in literally all the airways diseases, common ones (chronic bronchitis and asthma) and orphan ones (cystic fibrosis and primary ciliary dyskinesia) alike, irrespective of the ..
  27. Novel Reagents in Mouse Models of Autoimmune COPD
    Michael Borchers; Fiscal Year: 2012
    ..COPD, which includes chronic bronchitis and emphysema, is a major global health burden and morbidity and mortality are expected to expand in the ..
  28. Microfluidic Tissue Engineering of Small Airway Injuries
    Shuichi Takayama; Fiscal Year: 2010
    In diseases that involve mucus secretion and movement in the small airways, such as chronic bronchitis, cystic fibrosis or asthma, liquid plugs form occluding bridges that obstruct the airway and disrupt gas exchange...
  29. Targeting Airway Inflammation from Concentrated Animal Feeding Operation Dust
    Debra Romberger; Fiscal Year: 2013
    ..in concentrated animal feeding operations (CAFOs) experience work-related respiratory disease, particularly chronic bronchitis and chronic obstructive pulmonary disease (COPD)...
  30. The Pathobiology of Airway Disease in Alpha-1 Antitrypsin Deficiency
    Michael A Campos; Fiscal Year: 2010
    ..The overall goal of the research project is to understand the pathogenesis of airway inflammation and chronic bronchitis in AATD, a condition significantly associated with the worst quality of life and more severe airway disease ..
  31. The Impact of Tobacco Exposure on the Lungs Innate Defense System
    Robert Tarran; Fiscal Year: 2013
    ..we propose to develop a novel animal model of smoke exposure that more closely mimics the chronic bronchitis phenotype seen in humans with COPD...
  32. HDL cholesterol and chronic lower respiratory disease events in five cohorts
    R Graham Barr; Fiscal Year: 2013
    ..The most prevalent components of CLRD are chronic obstructive pulmonary disease (COPD), emphysema, chronic bronchitis and asthma...
  33. Optimizing vascular protective effects of antitrypsin in COPD
    Irina Petrache; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): ABSRACT: Emphysema and chronic bronchitis comprise the syndrome of COPD, now surpassing stroke as the 3rd leading cause of death in the US and a highly prevalent disease in Veterans...
  34. Severe Asthma Research Program (SARP)-Washington University
    Mario Castro; Fiscal Year: 2013
    ..these findings to those in groups with well- controlled asthma, normal controls, and diseased controls (chronic bronchitis) to identify features that can provide biologic targets unique to severe asthma...
  35. Airway Inspector: a chest imaging biomarker software platform for COPD
    Raul San Jose Estepar; Fiscal Year: 2013
    ..COPD has been traditionally dichotomized into the clinical phenotypes of emphysema and chronic bronchitis. Although spirometry is critical for diagnosis of COPD, FEV1 may be of limited value in a classification ..
  36. The A2a adenosine receptor modulates hyaluronan mediated lung inflammation
    MAUREEN RENEE HORTON; Fiscal Year: 2010
    ..We believe that these studies will provide the pre-clinical basis for the use of A2aR specific agonists in the treatment of inflammatory lung diseases such as idiopathic pulmonary fibrosis, chronic bronchitis and emphysema.
  37. Pharmacological characterization of a novel ROCK inhibitor for COPD
    Xiaoming Zhang; Fiscal Year: 2010
    ..efficacious ROCK inhibitor as maintenance therapy for airflow obstruction in patients with COPD, including chronic bronchitis and emphysema. Theron has identified a highly potent inhibitor of the human ROCK-1 and ROCK-2 isoenzymes...
  38. The Role of Anaerobic Bacterial Infection in Cystic Fibrosis
    RICHARD CHARLES BOUCHER; Fiscal Year: 2013
    ..g., chronic bronchitis. Such observations might change the way physicians approach antibiotic therapy of patients with airways ..
  39. Antibiofilm/Antimicrobial Combination for Infections Associated with Vascular Cat
    Mohammad D Mansouri; Fiscal Year: 2010
    ..a systemic remedy against toxicity with acetaminophen, is also used for inhalation therapy in patients with chronic bronchitis by breaking up the mucus...
  40. Th17 inflammation is responsible for mucous metaplasia in COPD
    Victor Kim; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Chronic mucus hypersecretion (CMH) and chronic bronchitis (CB) are variable but significant symptoms in COPD...
  41. Common targeting of the prostacyclin-PPARy axis in COPD and lung cancer
    Rubin M Tuder; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Smokers with the overlapping COPD phenotypes of airflow obstruction, chronic bronchitis or emphysema carry a significantly higher risk of developing lung cancer, as two recent studies indicated that ..
  42. Hyaluronan-induced signaling and gene regulation
    MAUREEN RENEE HORTON; Fiscal Year: 2010
    ..We believe that these studies will provide the pre-clinical basis for the use of specific agents in the treatment of inflammatory lung dis13ases such as idiopathic pulmonary fibrosis, chronic bronchitis and emphysema.
  43. Clinical Development of a Therapeutic Agent for COPD
    Indu Parikh; Fiscal Year: 2013
    ..under an active IND, a 21-day proof-of-concept Phase 2A clinical study in 172 COPD patients suffering from chronic bronchitis with its lead compound BIO-11006...
  44. LUNG DISEASE IN CHINESE TEXTILE WORKERS
    David C Christiani; Fiscal Year: 2013
    ..Specifically, for over five decades, controversy continues as to whether emphysema or chronic bronchitis is the basis of the observed airway obstruction...
  45. Mucociliary Function in Chronic Bronchitis
    MATTHIAS A SALATHE; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): In chronic bronchitis, mucociliary clearance is dysfunctional, especially during disease exacerbation...
  46. The Genetic Epidemiology of COPD in Costa Rica
    JUAN CARLOS CELEDON; Fiscal Year: 2009
    ..using short-tandem repeat (STR) markers and perform linkage analysis of six COPDrelated phenotypes: chronic bronchitis;airflow obstruction;FEV1;FEV1/FVC;bronchodilator responsiveness;and total serum IgE...
  47. Mucus Adhesion to Epithelial Cells and its Mobilization in COPD and CF
    Michael Rubinstein; Fiscal Year: 2012
    ..RELEVANCE (See Instructions): Chronic bronchitis (CB) is caused by both genetic and environmental factors and affects more than 14 million Americans...
  48. Pulmonary bacterial microbiome-epithelial cell interactions in COPD
    Fernando J Martinez; Fiscal Year: 2013
    ..of the EGFR pathway and mucin induction, thereby contributing to airway obstruction and symptoms of chronic bronchitis in COPD patients. This process will be ameliorated by a PDE4 inhibitor...
  49. Measures of Dust, Endotoxin, and Exhaled Nitric Oxide among Dairy Farm Workers
    MATTHEW WINSTON NONNENMANN; Fiscal Year: 2012
    ..The presence of lung inflammation may also be an indicator of asthma, chronic bronchitis, or chronic obstructive pulmonary disease (COPD)...
  50. Novel Mucolytic Agents
    BILL THELIN; Fiscal Year: 2013
    ..system characterize a complex of muco-obstructive airway diseases, such as cystic fibrosis (CF) and chronic bronchitis (CB). CB associated with CF affects 30,000 Americans, and the CB associated with environmental causes, e.g...
  51. Multidisciplinary Research Training in Pulmonary Medicine
    David B Jacoby; Fiscal Year: 2012
    ..These scientists will be prepared to address the public health issues raised by the increasing burden of asthma, chronic bronchitis, emphysema, acute respiratory distress syndrome, and other lung diseases.
  52. Quercetin Treatment of Airway Inflammation
    MARC HERSHENSON; Fiscal Year: 2006
    Inflammatory airways diseases - asthma, chronic bronchitis and cystic fibrosis - remain important causes of morbidity and mortality in the U.S...
  53. Hyperpolarized xenon functional MRI of human lung microstructure
    IULIAN RUSET; Fiscal Year: 2009
    Chronic Obstructive Pulmonary Disease (COPD), including emphysema and chronic bronchitis, is the fourth leading cause of death in the US, accounting for 120,000 fatalities annually...
  54. MACROPHAGE/NEUTROPHIL ELASTASE INHIBITOR
    EILEEN REMOLD O DONNELL; Fiscal Year: 1999
    ..proteinase inhibitors at tissue sites plays a role in the pathogenesis of emphysema, bronchiectasis, asthma, chronic bronchitis, sarcoidosis, respiratory distress syndrome, arthritis and some skin diseases...
  55. INHALED PARTICLE CHARACTERISTICS AND EARLY LUNG EFFECTS
    William Beckett; Fiscal Year: 2002
    ..Investigator's Abstract) Chronic obstructive pulmonary disease (COPD) is a disabling condition produced by chronic bronchitis (airway inflammation and mucus hypersecretion) and emphysema (loss of alveolar surface area)...
  56. PLAGL2 Expression in Emphysema Patient Lungs
    Yih Sheng Yang; Fiscal Year: 2009
    ..staining of tissue sections from patients with histologic evidence of emphysema, COPD with predominantly chronic bronchitis, or controls...
  57. Regulation of Airway Goblet Cell Mucin Secretion
    C Davis; Fiscal Year: 2007
    DESCRIPTION: The obstructive pulmonary diseases (OPD), cystic fibrosis, chronic bronchitis, bronchiectasis, emphysema, and asthma, are inflammatory diseases with very different inflammatory cell profiles, cytokine responses, etc; mucin ..
  58. Protease Regulation of Airway Cell Sodium Transport
    Robert Bridges; Fiscal Year: 2005
    ..respiratory diseases including cystic fibrosis, chronic obstructive pulmonary disease, asthma and acute and chronic bronchitis. Pharmacological modulation of Na+ transport is expected to improve mucociliary clearance in these diseases...
  59. POLYMERIC STRUCTURE OF MUCOUS GLYCOPROTEINS
    Veer Bhavanandan; Fiscal Year: 1993
    ..Mucins are believed to have a significant role in a variety of pathophysiologic processes including asthma, chronic bronchitis, cystic fibrosis, peptic ulcers, chronic gastritis, infertility and inflammatory bowel diseases...
  60. COAL DUST PARTICLE SIZE AND RESPIRATORY DISEASE
    Thomas Robins; Fiscal Year: 1991
    ..of particle size fractions and temporal aspects of exposure to coal mine dust to the development of chronic bronchitis and airways obstruction in underground coal miners...
  61. PATHOPHYSIOLOGY OF AIRWAY EFFECTS TO COLD EXPOSURE
    EDWARD MCFADDEN; Fiscal Year: 1999
    ..the pulmonary mechanical effects of cold exposure in health and in subjects with asthma, rhinitis, and chronic bronchitis; (2) determine the mechanisms by which skin cooling produces bronchial narrowing; (3) evaluate whether cold ..
  62. BTP1000 & The Clearance of Mucus From the Lungs
    DONOVAN YEATES; Fiscal Year: 2002
    Patients with chronic bronchitis, bronchiectasis, cystic fibrosis, asthmatic bronchitis and asthma have inspissated mucus and plugs of highly viscoelastic mucus...
  63. ANALYSIS OF THE AIRWAY ANTIPROTEINASE DEFENSE SYSTEM
    Sule Cataltepe; Fiscal Year: 2006
    ..play a major role in the development of inflammatory lung diseases such as cystic fibrosis, asthma, chronic bronchitis, emphysema and chronic lung disease of prematurity...