Genomes and Genes
Summary: Inflammation of the bronchioles.
Articles from Journal RESEARCH
Articles from Journal RESEARCH1
Publications285 found, 100 shown here
- BronchiolitisRosalind L Smyth
Division of Child Health, School of Reproductive and Developmental Medicine, University of Liverpool, Alder Hey Children s Hospital, Liverpool L12 2AP, UK
Lancet 368:312-22. 2006b>Bronchiolitis is a distressing, potentially life-threatening respiratory condition that affects young babies...
- Respiratory bronchiolitis: a clinicopathologic study in current smokers, ex-smokers, and never-smokersMostafa Fraig
Department of Pathology, Upstate Medical University, Syracuse, New York, USA
Am J Surg Pathol 26:647-53. 2002The clinical and pathologic features of 109 cases of respiratory bronchiolitis (RB) identified from review of 156 consecutive surgical lung biopsy specimens were studied...
- Association between common Toll-like receptor 4 mutations and severe respiratory syncytial virus diseaseGuy Tal
Pediatric Pulmonary Unit, Edith Wolfson Medical Center, Tel Aviv University, Holon, Israel
J Infect Dis 189:2057-63. 2004The clinical spectrum of respiratory syncytial virus (RSV) bronchiolitis in previously healthy infants is extremely variable. Thus, it is likely that factors such as genetic heterogeneity contribute to disease severity...
- Prospective multicenter study of viral etiology and hospital length of stay in children with severe bronchiolitisJonathan M Mansbach
Department of Medicine, Children s Hospital Boston, Boston 02115, USA
Arch Pediatr Adolesc Med 166:700-6. 2012To determine whether hospital length of stay(LOS) for acute bronchiolitis is influenced by the infecting pathogen.
- Risk factors in children hospitalized with RSV bronchiolitis versus non-RSV bronchiolitisCarla G García
Department of Pediatrics, Division of Pediatric Infectious Diseases, University of Texas Southwestern Medical Center, Texas, USA
Pediatrics 126:e1453-60. 2010The trends in hospitalization rates and risk factors for severe bronchiolitis have not been recently described, especially after the routine implementation of prophylaxis for respiratory syncytial virus (RSV) infections.
- Review of epidemiology and clinical risk factors for severe respiratory syncytial virus (RSV) infectionRobert C Welliver
Department of Pediatrics, State University of New York at Buffalo, School of Medicine and Biomedical Sciences, and the Division of Infectious Diseases, Children s Hospital of Buffalo, New York 14222, USA
J Pediatr 143:S112-7. 2003..Pulmonary hypertension and cyanosis are associated with worse outcomes in infants with congenital heart disease, and prolonged viral replication accounts for more severe illness in immunocompromised individuals...
- The impact of dual viral infection in infants admitted to a pediatric intensive care unit associated with severe bronchiolitisNathalie Richard
Service d urgence et de réanimation pédiatriques, Hopital Edouard Herriot, Lyon, France
Pediatr Infect Dis J 27:213-7. 2008b>Bronchiolitis is a major cause of morbidity and mortality in early childhood worldwide. The presence of more than one pathogen may influence the natural history of acute bronchiolitis in infants.
- Cord blood vitamin D deficiency is associated with respiratory syncytial virus bronchiolitisMirjam E Belderbos
Department of Pediatrics, University Medical Center Utrecht, Utrecht
Pediatrics 127:e1513-20. 2011..Respiratory syncytial virus (RSV) is the most important pathogen causing severe lower respiratory tract infection (LRTI) in infants. Epidemiologic and basic studies suggest that vitamin D may protect against RSV LRTI...
- Parental and household smoking and the increased risk of bronchitis, bronchiolitis and other lower respiratory infections in infancy: systematic review and meta-analysisLaura L Jones
UK Centre for Tobacco Control Studies, Division of Epidemiology and Public Health, University of Nottingham, Clinical Sciences Building, Nottingham City Hospital, Nottingham, NG5 1PB, UK
Respir Res 12:5. 2011..aim of this paper is to provide an updated systematic review and meta-analysis of studies of the association between passive smoking and LRI, and with diagnostic subcategories including bronchiolitis, in infants aged two years and under.
- Evaluation of the utility of radiography in acute bronchiolitisSuzanne Schuh
Division of Paediatric Emergency Medicine, Department of Pediatrics, Research Institute, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada
J Pediatr 150:429-33. 2007To determine the proportion of radiographs inconsistent with bronchiolitis in children with typical presentation of bronchiolitis and to compare rates of intended antibiotic therapy before radiography versus those given antibiotics after ..
- Long-term airway morbidity following viral LRTI in early infancy: recurrent wheezing or asthma?Renato T Stein
Departamento de Pediatria, Faculdade de Medicina, Pontificia Universidade Catolica, Porto Alegre, Brazil
Paediatr Respir Rev 10:29-31. 2009..Respiratory syncytial virus (RSV) is an agent especially associated with severe cases of bronchiolitis affecting young infants in winter months and has a typical seasonal pattern...
- Broad respiratory virus detection in infants hospitalized for bronchiolitis by use of a multiplex RT-PCR DNA microarray systemAntoine Huguenin
Medical and Molecular Virology Unit and EA 484, University Hospital Center and Medical School of Reims, Reims, France
J Med Virol 84:979-85. 2012..RT-PCR DNA microarray in diagnosis and epidemiological survey of viral infections in infants hospitalized for bronchiolitis was assessed...
- Infection with multiple viruses is not associated with increased disease severity in children with bronchiolitisH Kim Brand
Department of Pediatrics, Radboud University Nijmegen Medical Centre, P O Box 9101, 6500 HB, Nijmegen, The Netherlands
Pediatr Pulmonol 47:393-400. 2012..This study evaluated the association between the detection of multiple viruses by RT-PCR and disease severity in children with bronchiolitis.
- The outcome after severe bronchiolitis is related to gender and virusIngvild B Mikalsen
Department of Pediatrics, Stavanger University Hospital, Stavanger, Norway
Pediatr Allergy Immunol 23:391-8. 2012The association between bronchiolitis in the first year of life and subsequent asthma, atopy, airway obstruction and bronchial hyper-responsiveness (BHR) is unsettled...
- Specific increase in local IL-17 production during recovery from primary RSV bronchiolitisTina E Faber
Department of Pediatrics, Medical Center Leeuwarden, Leeuwarden, The Netherlands
J Med Virol 84:1084-8. 2012Although Respiratory syncytial virus (RSV) bronchiolitis is the most important cause of hospital admission for infants during the winter season, the pathogenesis is largely unknown...
- Respiratory bronchiolitis-associated interstitial lung disease with fibrosis is a lesion distinct from fibrotic nonspecific interstitial pneumonia: a proposalSamuel A Yousem
Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA 15213 2582, USA
Mod Pathol 19:1474-9. 2006..of clinical and radiographic chronic interstitial lung disease are presented that have features of respiratory bronchiolitis-associated interstitial lung disease, but were associated with a respiratory bronchiolitis having extensive ..
- In very young infants severity of acute bronchiolitis depends on carried virusesChristophe Marguet
Respiratory Diseases, Allergy and CF Unit, Pediatric Department, Rouen University Hospital Charles Nicolle, Rouen, France
PLoS ONE 4:e4596. 2009RT amplification reaction has revealed that various single viruses or viral co-infections caused acute bronchiolitis in infants, and RV appeared to have a growing involvement in early respiratory diseases...
- Bronchiolitis: recent evidence on diagnosis and managementJoseph J Zorc
MSCE, Children s Hospital of Philadelphia, Division of Emergency Medicine, Main AS01, 34th Street and Civic Center Boulevard, Philadelphia, PA 19104 4399, USA
Pediatrics 125:342-9. 2010Viral bronchiolitis is a leading cause of acute illness and hospitalization of young children...
- Functional genetic variation in NFKBIA and susceptibility to childhood asthma, bronchiolitis, and bronchopulmonary dysplasiaSalman Ali
Department of Pediatrics, British Columbia Children s Hospital and Child and Family Research Institute, University of British Columbia, Vancouver, British Columbia V6H 3V4, Canada
J Immunol 190:3949-58. 2013..relevant genetic variation in the promoter of NFKBIA is associated with differential susceptibility to severe bronchiolitis following infection with respiratory syncytial virus, airway hyperresponsiveness, and severe bronchopulmonary ..
- Steroids and bronchodilators for acute bronchiolitis in the first two years of life: systematic review and meta-analysisLisa Hartling
Alberta Research Centre for Health Evidence, Department of Pediatrics, University of Alberta, 11402 University Avenue, Edmonton, AB, Canada T6G 2J3
BMJ 342:d1714. 2011To evaluate and compare the efficacy and safety of bronchodilators and steroids, alone or combined, for the acute management of bronchiolitis in children aged less than 2 years.
- Human metapneumovirus and lower respiratory tract disease in otherwise healthy infants and childrenJohn V Williams
Division of Infectious Diseases, Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN 37232 2581, USA
N Engl J Med 350:443-50. 2004..We sought to determine the role of human metapneumovirus in lower respiratory tract illness in previously healthy infants and children...
- Incidence and risk factors of hospitalization for bronchiolitis in preterm children: a retrospective longitudinal study in ItalyPatrizio Pezzotti
Agency for Public Health of Lazio Region, Scientific Direction Unit, Rome, Italy
BMC Pediatr 9:56. 2009b>Bronchiolitis is a distressing, potentially life-threatening respiratory condition that affects infants. We evaluated the incidence and risk factors of hospitalization for broncholitis in preterm infants (i.e...
- The polymorphism of IL-17 G-152A was associated with childhood asthma and bacterial colonization of the hypopharynx in bronchiolitisJiehua Chen
Division of Respiratory Medicine, Children s Hospital of Chongqing Medical University, Chongqing, 400014, China
J Clin Immunol 30:539-45. 2010..We investigated the association between single-nucleotide polymorphism (SNP) of IL-17 (rs2275913, IL-17 G-152A) and asthma-related traits. Its effect on IL-17 production was also attractive...
- Epinephrine and dexamethasone in children with bronchiolitisAmy C Plint
Department of Pediatrics, University of Ottawa and Children s Hospital of Eastern Ontario, Ottawa, Canada
N Engl J Med 360:2079-89. 2009Although numerous studies have explored the benefit of using nebulized epinephrine or corticosteroids alone to treat infants with bronchiolitis, the effectiveness of combining these medications is not well established.
- Persistence of rhinovirus and enterovirus RNA after acute respiratory illness in childrenTuomas Jartti
Department of Pediatrics, Turku University Hospital, Turku, Finland
J Med Virol 72:695-9. 2004..The study shows that after the onset of symptomatic respiratory infection enterovirus RNA may take 2-3 weeks and rhinovirus RNA 5-6 weeks to disappear from nasal mucus...
- Correlation of viral load of respiratory pathogens and co-infections with disease severity in children hospitalized for lower respiratory tract infectionAnna Franz
Department of Pediatrics, Heinrich Heine University Dusseldorf, Dusseldorf, Germany
J Clin Virol 48:239-45. 2010..The clinical significance of viral load and co-infections in children with respiratory infections is not clear...
- Bilateral bronchiectasis and bronchiolitis at thin-section CT: diagnostic implications in nontuberculous mycobacterial pulmonary infectionWon Jung Koh
Division of Pulmonary and Critical Care Medicine, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Ilwon Dong, Kangnam Ku, Seoul 135 710, Korea
Radiology 235:282-8. 2005..of nontuberculous mycobacterial (NTM) pulmonary infection in patients with bilateral bronchiectasis and bronchiolitis at chest computed tomography (CT) and whether CT findings are indicative of Mycobacterium avium-intracellulare ..
- Clinical predictors of nasal continuous positive airway pressure requirement in acute bronchiolitisJordan Evans
Department of Paediatric Emergency Medicine, Chelsea and Westminster Hospital, London, UK
Pediatr Pulmonol 47:381-5. 2012There is growing use of nasal continuous positive airway pressure ventilation (nCPAP) for infants with bronchiolitis, based on clinical assessment of severity...
- Therapeutic approach to bronchiolitis: why pediatricians continue to overprescribe drugs?Daniele De Brasi
Pediatric Unit, AORN A Cardarelli, Naples, Italy
Ital J Pediatr 36:67. 2010b>Bronchiolitis guidelines suggest that neither bronchodilators nor corticosteroids, antiviral and antibacterial agents should be routinely used. Although recommendations, many clinicians persistently prescribe drugs for bronchiolitis.
- Lung ultrasound in bronchiolitis: comparison with chest X-rayVito Antonio Caiulo
Department of Pediatrics, Perrino Hospital, Piazza Angeli, 3 72100 Brindisi, Italy
Eur J Pediatr 170:1427-33. 2011The diagnosis of bronchiolitis is based mainly on the patient's medical history and physical examination. However, in severe cases, a further evaluation including chest X-ray (CXR) may be necessary...
- Metabolomics in paediatric respiratory diseases and bronchiolitisAlessandra Atzei
Neonatal Intensive Care Unit, Puericultura Institute and Neonatal Section, University of Cagliari, Italy
J Matern Fetal Neonatal Med 24:59-62. 2011..the application of clinical metabolomics in three different areas of respiratory diseases in pediatrics: asthma, pneumonia and bronchiolitis. Comparison between two 1H-NMR urine spectra by two bronchiolitis patients are also presented.
- [Rhinovirus and acute bronchiolitis in young infants]Paulo M C Pitrez
Departamento de Pediatria, Pontificia Universidade Catolica do Rio Grande do Sul PUCRS, Porto Alegre, RS, Brazil
J Pediatr (Rio J) 81:417-20. 2005To determine the prevalence of rhinovirus infection in hospitalized young infants with acute bronchiolitis.
- Viral-mediated inhibition of antioxidant enzymes contributes to the pathogenesis of severe respiratory syncytial virus bronchiolitisYashoda M Hosakote
Department of Pediatrics, The University of Texas Medical Branch at Galveston, Galveston, TX 77555 0366, USA
Am J Respir Crit Care Med 183:1550-60. 2011..We have previously shown that RSV induces reactive oxygen species in cultured cells and oxidative injury in the lungs of experimentally infected mice. The mechanism(s) of RSV-induced oxidative stress in vivo is not known...
- Reduced lung function both before bronchiolitis and at 11 yearsS W Turner
University Department of Paediatrics, Princess Margaret Hospital for Children, Perth, Australia
Arch Dis Child 87:417-20. 2002We have previously shown an association between reduced premorbid lung function (V'maxFRC) and bronchiolitis. We hypothesised that individuals with bronchiolitis will go on to have reduced lung function and increased respiratory symptoms ..
- Macrophage impairment underlies airway occlusion in primary respiratory syncytial virus bronchiolitisJennifer L Reed
Respiratory, Inflammation, and Autoimmunity Group, MedImmune, Gaithersburg, Maryland, USA
J Infect Dis 198:1783-93. 2008Although respiratory syncytial virus (RSV) infection is the most important cause of bronchiolitis in infants, the pathogenesis of RSV disease is poorly described...
- Bronchiolitis management before and after the AAP guidelinesKavita Parikh
Division of Hospitalist Medicine, 111 Michigan Ave NW, Washington, DC 20010
Pediatrics 133:e1-7. 2014Evidence-based practice guidelines for bronchiolitis management published by the American Academy of Pediatrics in 2006 recommend supportive care with limited diagnostic testing and treatment...
- Situs inversus totalis: the association of Kartagener's syndrome with diffuse bronchiolitis and azoospermiaVikas Mittal
Department of Respiratory Medicine, Vallabhbhai Patel Chest Institute, University of Delhi, Delhi, India
Arch Bronconeumol 48:179-82. 2012..Association of diffuse bronchiolitis (DB) with KS has been documented from Japan only...
- Non-invasive ventilation for severe bronchiolitis: analysis and evidenceMichaela R Lazner
Department of Emergency Medicine, Sheffield Children s Hospital, Sheffield, UK
Pediatr Pulmonol 47:909-16. 20121) To examine whether infants with severe bronchiolitis, fulfilling criteria for further respiratory support, could be managed outside a Pediatric Intensive Care Unit (PICU) with non-invasive ventilation (NIV) alone...
- Chest physiotherapy for acute bronchiolitis in paediatric patients between 0 and 24 months oldMarta Roqué I Figuls
Iberoamerican Cochrane Centre, Institute of Biomedical Research IIB Sant Pau, Barcelona, CIBER Epidemiologia y Salud Pública CIBERESP, Spain, Barcelona, Spain
Cochrane Database Syst Rev 2:CD004873. 2012This is an update of the original Cochrane review published in 2005 and updated in 2007. Acute bronchiolitis is the leading cause of medical emergencies during winter in children younger than two years of age...
- Bordetella pertussis infection attenuates clinical course of acute bronchiolitisBahaa Abu Raya
Department of Pediatrics, Bnai Zion Medical Center, Haifa, Israel
Pediatr Infect Dis J 32:619-21. 2013..The aim of this study was to assess clinical characteristics of BP infection, and its effect on disease severity in young children hospitalized with acute bronchiolitis.
- Comparison of the effects that two different respiratory physical therapy techniques have on cardiorespiratory parameters in infants with acute viral bronchiolitisMelissa Karina Pupin
Departamento de Pediatria, Universidade Estadual de Campinas, Campinas, SP, Brasil
J Bras Pneumol 35:860-7. 2009..compare the expiratory flow increase technique (EFIT) and vibration accompanied by postural drainage (PD) in terms of their effects on the heart rate (HR), respiratory rate (RR) and SpO(2) of infants with acute viral bronchiolitis (AVB).
- LDH concentration in nasal-wash fluid as a biochemical predictor of bronchiolitis severityFederico R Laham
Baylor College of Medicine, Department of Pediatrics, One Baylor Plaza, Room 248E MS280, Houston, TX 77030, USA
Pediatrics 125:e225-33. 2010Because the decision to hospitalize an infant with bronchiolitis is often supported by subjective criteria and objective indicators of bronchiolitis severity are lacking, we tested the hypothesis that lactate dehydrogenase (LDH), which ..
- Current therapy for bronchiolitisPrasad Nagakumar
Department of Paediatric Respiratory Medicine Paediatric Cystic Fibrosis Centre, Children s Hospital for Wales, Cardiff, UK
Arch Dis Child 97:827-30. 2012b>Bronchiolitis is a common, self-limiting, seasonal viral respiratory tract infection in infancy accounting for the majority of hospital admissions in this age group...
- Randomized placebo-controlled trial on azithromycin to reduce the morbidity of bronchiolitis in Indigenous Australian infants: rationale and protocolAnne B Chang
Child Health Division, Menzies School of Health Research, Charles Darwin University, Darwin, Northern Territory, Australia
Trials 12:94. 2011..Globally, bronchiolitis is the most common form of acute lower respiratory infections during infancy...
- Bronchiolitis-associated hospitalizations among US children, 1980-1996D K Shay
Respiratory and Enteric Viruses Branch, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
JAMA 282:1440-6. 1999Respiratory syncytial virus (RSV) causes more lower respiratory tract infections, often manifested as bronchiolitis, among young children than any other pathogen...
- The overlap between respiratory bronchiolitis and desquamative interstitial pneumonia in pulmonary Langerhans cell histiocytosis: high-resolution CT, histologic, and functional correlationsRobert Vassallo
Thoracic Diseases Research Unit, Division of Pulmonary, Critical Care and Internal Medicine, Mayo Clinic and Foundation, Rochester, MN 55905, USA
Chest 124:1199-205. 2003To characterize the histologic, high-resolution CT (HRCT), and functional correlates of respiratory bronchiolitis (RB)/desquamative interstitial pneumonia (DIP)-like changes in biopsy specimens of adults with pulmonary Langerhans cell ..
- Infant swimming in chlorinated pools and the risks of bronchiolitis, asthma and allergyC Voisin
Dept of Public Health, Catholic University of Louvain, Louvain, Belgium
Eur Respir J 36:41-7. 2010..The aim of the present study was to assess the influence of swimming in chlorinated pools on the risks of bronchiolitis and its late consequences. A total of 430 children (47% female; mean age 5...
- Duration of illness in infants with bronchiolitis evaluated in the emergency departmentFrank D Petruzella
Division of Emergency Medicine, Department of Pediatrics, Medical College of Wisconsin, Milwaukee, Wisconsin, USA
Pediatrics 126:285-90. 2010To describe the duration of illness in infants with first-time bronchiolitis who present to an emergency department (ED) and assess the burden of the illness on caregivers and families.
- Nebulized 5% or 3% hypertonic or 0.9% saline for treating acute bronchiolitis in infantsKhalid Al-Ansari
Division of Pediatric Emergency Medicine, Department of Pediatrics, Hamad Medical Corporation, Doha, Qatar
J Pediatr 157:630-4, 634.e1. 2010To compare the efficacy and safety of 5%, 3%, and 0.9% saline solution for treating acute bronchiolitis in the prehospital setting.
- Severe chronic bronchiolitis as the presenting feature of primary Sjögren's syndromeRaphael Borie
Assistance Publique Hopitaux de Paris, Hopital Bichat, Service de Pneumologie A, Centre de Compétence maladies rares pulmonaires, Paris, France
Respir Med 105:130-6. 2011..We describe here 5 patients with severe chronic bronchiolitis revealing primary Sjögren's syndrome...
- Characterization of the resistance of SJL/J mice to pneumonia virus of mice, a model for infantile bronchiolitis due to a respiratory syncytial virusStéphanie Glineur
Department of Morphology and Pathology, College of Veterinary Medicine, University of Liege, Sart Tilman, Belgium
PLoS ONE 7:e44581. 2012....
- Sustaining the implementation of an evidence-based guideline for bronchiolitisP H Perlstein
Division of Health Policy and Clinical Effectiveness, Children s Hospital Medical Center, Cincinnati, OH, USA
Arch Pediatr Adolesc Med 154:1001-7. 2000To describe the changes occurring over a 3-year period after implementation of an evidence-based clinical practice guideline for the care of infants with bronchiolitis.
- Bronchiolitis management in pediatric emergency departments in Australia and New Zealand: a PREDICT studyFranz E Babl
Emergency Department, Royal Children s Hospital, Melbourne, Vic, Australia
Pediatr Emerg Care 24:656-8. 2008b>Bronchiolitis is the most frequent reason for admission in infants...
- HLA-specific antibodies are risk factors for lymphocytic bronchiolitis and chronic lung allograft dysfunctionAlin L Girnita
Department of Pathology, University of Pittsburgh, Pittsburgh, PA, USA
Am J Transplant 5:131-8. 2005b>Bronchiolitis obliterans syndrome (BOS) represents a major limitation in lung transplantation. While acute rejection is widely considered the most important risk factor for BOS, the impact of HLA-specific antibodies is less understood...
- Increasing burden and risk factors for bronchiolitis-related medical visits in infants enrolled in a state health care insurance planKecia N Carroll
Department of Pediatrics, Division of General Pediatrics, Child and Adolescent Health Research Unit, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 8300, USA
Pediatrics 122:58-64. 2008The goals were to estimate the year-round burden of health care visits attributable to bronchiolitis and to identify risk factors for bronchiolitis in term healthy infants.
- Lymphocyte apoptosis in acute respiratory syncytial virus bronchiolitisM F E Roe
Department of Paediatrics, University of Cambridge, Cambridge, UK
Clin Exp Immunol 137:139-45. 2004..RSV bronchiolitis in infants is associated with a transient decline in circulating lymphocytes...
- Pharmacologic treatment of bronchiolitis in infants and children: a systematic reviewValerie J King
Cecil B Sheps Center for Health Services Research, University of North Carolina at Chapel Hill, 725 Airport Road, Campus Box 7590, Chapel Hill, NC 27599 7595, USA
Arch Pediatr Adolesc Med 158:127-37. 2004b>Bronchiolitis is the most common lower respiratory tract infection in infants. Up to 3% of all children in their first year of life are hospitalized with bronchiolitis...
- Descriptive epidemiological features of bronchiolitis in a population-based cohortMieke Koehoorn
School of Environmental Health, Centre for Health Services and Policy Research, University of British Columbia, 5804 Fairview Ave, Vancouver, British Columbia, Canada V6T 1Z3
Pediatrics 122:1196-203. 2008The goal was to investigate the epidemiological features of incident bronchiolitis by using a population-based infant cohort.
- Risk factors for bronchiolitis-associated deaths among infants in the United StatesRobert C Holman
Respiratory and Enteric Viruses Branch, Division of Viral and Ricksettial Diseases, National Center for Infectious Diseases, Center for Disease Control and Prevention DHHS, Atlanta, GA 30333, USA
Pediatr Infect Dis J 22:483-90. 2003Risk factors for bronchiolitis deaths have not been described on a national level. We examined the epidemiology of and identified risk factors for bronchiolitis-associated deaths among infants in the United States.
- Bronchiolitis in infantsH B Panitch
University of Pennsylvania School of Medicine, Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
Curr Opin Pediatr 13:256-60. 2001b>Bronchiolitis is a common cause of wheezing among infants...
- Diagnosis and testing in bronchiolitis: a systematic reviewW Clayton Bordley
Departments of Pediatrics and Surgery, Division of Emergency Medicine, Duke University Medical Center, DUMC Box 3096, Durham, NC 27710, USA
Arch Pediatr Adolesc Med 158:119-26. 2004The diagnosis of bronchiolitis is based on typical history and results of a physical examination...
- Influence of ambient air pollutant sources on clinical encounters for infant bronchiolitisCatherine J Karr
Department of Pediatrics, University of Washington, 401 Broadway, Box 359739, Seattle, WA 98104, USA
Am J Respir Crit Care Med 180:995-1001. 2009Data regarding the influence of ambient air pollution on infant bronchiolitis are few.
- Risks of severity and readmission of Indigenous and non-Indigenous children hospitalised for bronchiolitisEmily J Bailey
Queensland Children s Respiratory Centre, Royal Children s Hospital, Brisbane, QLD, Australia
J Paediatr Child Health 45:593-7. 2009To describe the characteristics of children admitted to Royal Darwin Hospital with bronchiolitis, and to compare the severity of illness and incidence of subsequent readmission in Indigenous and non-Indigenous children.
- Respiratory syncytial virus infection and immunoprophylaxis for selected high-risk children in Central AustraliaSrinivas Bolisetty
Department of Paediatrics, Alice Springs Hospital, Alice Springs, Australia
Aust J Rural Health 13:265-70. 2005There are limited data on the epidemiology and viral aetiology of bronchiolitis in Central Australia and respiratory syncytial virus (RSV) immunoprophylaxis in an Australian population.
- Direct medical costs of bronchiolitis hospitalizations in the United StatesAndrea J Pelletier
EMNet Coordinating Center, Department of Emergency Medicine, Massachusetts General Hospital, 326 Cambridge St, 4th Floor, Boston, MA 02114, USA
Pediatrics 118:2418-23. 2006Although bronchiolitis is the leading cause of hospitalization for infants, there are limited data describing the epidemiology of bronchiolitis hospitalizations, and the associated cost is unknown...
- [Effects of nasal continuous positive airway pressure ventilation in infants with severe acute bronchiolitis]S Larrar
Assistance Publique Hopitaux de Paris, Service de Réanimation Pédiatrique, Hopital de Bicetre, 78, rue du General Leclerc, 94270 Le Kremlin Bicetre, France
Arch Pediatr 13:1397-403. 2006Usefulness of nasal continuous positive airway pressure (NCPAP) in severe acute bronchiolitis has been checked. The objective of this descriptive study was to evaluate the feasibility, safety and risk factors of NCPAP failure.
- Nasal lavage leukotrienes in infants with RSV bronchiolitisLiviana Da Dalt
Department of Pediatrics, University of Padova, Padova, Italy
Pediatr Allergy Immunol 18:100-4. 2007Respiratory syncytial virus (RSV) bronchiolitis is a very common infection in infants and, after the acute phase, a number of patients develop a reactive airway disease that lasts for years...
- Complications in infants hospitalized for bronchiolitis or respiratory syncytial virus pneumoniaDouglas F Willson
PICU and the Division of Pediatric Critical Care, University of Virginia Children s Medical Center, Charlottesville, Virginia, USA
J Pediatr 143:S142-9. 2003To characterize complications among infants hospitalized for bronchiolitis or respiratory syncytial virus (RSV).
- Comparison of pulmonary abnormalities on high-resolution computed tomography in patients with early versus longstanding rheumatoid arthritisShunsuke Mori
Department of Rheumatology, Kumamoto Saishunsou National Hospital, Kumamoto, Japan
J Rheumatol 35:1513-21. 2008..To identify the predominant radiological abnormalities in the lungs of patients with early rheumatoid arthritis (RA) and in those with longstanding RA...
- Bronchiolitis in Abha, Southwest Saudi Arabia: viral etiology and predictors for hospital admissionMohammed A Al-Shehri
Department of Pediatrics, King Khalid University, Kingdom of Saudi Arabia
West Afr J Med 24:299-304. 2005b>Bronchiolitis is the most common lower respiratory tract infection in children less than 24 months of age and the most frequent cause of hospitalization in infants under 6 months of age.
- Sole pathogen in acute bronchiolitis: is there a role for other organisms apart from respiratory syncytial virus?Dan Miron
Department of Pediatric A, Ha Emek Medical Center, Afula 18101, Israel
Pediatr Infect Dis J 29:e7-e10. 2010Acute bronchiolitis (AB) is a common disease of young children with peak incidence during the winter season...
- Respiratory bronchiolitis-interstitial lung disease: long-term outcomeJoshua Portnoy
National Jewish Medical and Research Center, 1400 Jackson St, Denver, CO 80206, USA
Chest 131:664-71. 2007The clinical and physiologic features of respiratory bronchiolitis (RB)-interstitial lung disease (ILD) have been previously described; however, the natural history and outcome have not been systematically evaluated...
- Decreasing unnecessary utilization in acute bronchiolitis care: results from the value in inpatient pediatrics networkShawn Ralston
Department of Pediatrics, Division of Inpatient Pediatrics, University of Texas Health Science Center San Antonio, San Antonio, Texas, USA
J Hosp Med 8:25-30. 2013Acute viral bronchiolitis is the most common diagnosis resulting in hospital admission in pediatrics...
- Airway IFN-γ production during RSV bronchiolitis is associated with eosinophilic inflammationChang Keun Kim
Department of Pediatrics, Asthma and Allergy Center, Inje University Sanggye Paik Hospital, Seoul, Korea
Lung 190:183-8. 2012This study was designed to investigate the possible role of IFN-γ in eosinophil degranulation that occurs during respiratory syncytial virus (RSV) bronchiolitis.
- Heliox therapy in bronchiolitis: phase III multicenter double-blind randomized controlled trialMina M Chowdhury
Department of Pediatrics, Wright Fleming Institute, Imperial College, London, United Kingdom
Pediatrics 131:661-9. 2013Supportive care remains the mainstay of therapy in bronchiolitis. Earlier studies suggest that helium-oxygen therapy may be beneficial, but evidence is limited...
- Racemic adrenaline and inhalation strategies in acute bronchiolitisHåvard Ove Skjerven
Department of Pediatrics, Oslo University Hospital, Oslo, Norway
N Engl J Med 368:2286-93. 2013Acute bronchiolitis in infants frequently results in hospitalization, but there is no established consensus on inhalation therapy--either the type of medication or the frequency of administration--that may be of value...
- Burden of infant bronchiolitis: data from a hospital networkD Che
Institut de Veille Sanitaire, Saint Maurice, France
Epidemiol Infect 138:573-5. 2010In France, surveillance of bronchiolitis is based on a pilot network of hospital emergency departments. The study was a 1-year observational study (2007-2008) carried out in a central region of metropolitan France...
- The risk of bronchiolitis hospitalisation following administration of a group B meningococcal vaccine in New ZealandPaul Stehr-Green
Department of Epidemiology, University of Washington, Seattle, Washington, USA
N Z Med J 120:U2746. 2007..participants (including five children who had been vaccinated with this vaccine) were hospitalised due to acute bronchiolitis. We examined more closely the potential association between bronchiolitis hospitalisation and this vaccine.
- Bronchiolitis-associated encephalopathy in critically-ill infants: an underestimated complication?Roberto Antonucci
Department of Pediatrics and Clinical Medicine, University of Cagliari, Cagliari, Italy
J Matern Fetal Neonatal Med 23:431-6. 2010To investigate the bronchiolitis-associated encephalopathy in critically ill infants.
- Association of respiratory syncytial virus bronchiolitis with the interleukin 8 gene region in UK familiesJ Hull
University Department of Paediatrics, Level 4, John Radcliffe Hospital, Oxford OX3 9DU
Thorax 55:1023-7. 2000..Why some develop bronchiolitis is poorly understood; it is not known whether there is a genetic component...
- Epidemiology of hospitalization for acute bronchiolitis in children: differences between RSV and non-RSV bronchiolitisD Hervas
Son Dureta University Hospital, Palma de Mallorca, The Balearic Islands, Spain
Eur J Clin Microbiol Infect Dis 31:1975-81. 2012..clinical, management and outcome differences between respiratory syncytial virus (RSV) positive and negative bronchiolitis. A retrospective review of the medical records of children ≤ 2 years of age with acute bronchiolitis between ..
- [Prospective regional study of an epidemic of respiratory syncytial virus (RSV) bronchiolitis]M Grimaldi
Service de Pediatrie 2, Hôpital d Enfants, 10, Boulevard du Maréchal de Lattre de Tassigny, 21034 Dijon, France
Arch Pediatr 9:572-80. 2002..admission in pediatric intensive care units (PICU) among infants hospitalized for treatment of RSV induced bronchiolitis. This study was population-based and was conducted in Burgundy, a French region with 1,800,000 inhabitants ..
- Rhinovirus bronchiolitis and recurrent wheezing: 1-year follow-upF Midulla
Dept of Paediatrics, Sapienza University Rome, Viale Regina Elena 324, 00161 Rome, Italy
Eur Respir J 39:396-402. 2012The association between bronchiolitis and recurrent wheezing remains controversial...
- RSV-induced bronchiolitis but not upper respiratory tract infection is accompanied by an increased nasal IL-18 responseInesz J van Benten
Department of Otorhinolaryngology, Erasmus Medical Centre Rotterdam, The Netherlands
J Med Virol 71:290-7. 2003The aim of this study was to investigate potential differences in the local nasal immune response between bronchiolitis and upper respiratory tract infection induced by respiratory syncytial virus (RSV)...
- Prevalence of Bordetella pertussis and Bordetella parapertussis in infants presenting to the emergency department with bronchiolitisPaul F Walsh
Department of Emergency Medicine, Kern Medical Center, Bakersfield, California 93305, USA
J Emerg Med 40:256-61. 2011..The clinical presentation of Bordetella pertussis can overlap with that of respiratory syncytial virus (RSV), and coinfection does occur, but management differs...
- Short term effects of adrenaline in bronchiolitis: a randomised controlled trialA Abul-Ainine
Children s Hospital, Leicester Royal Infirmary, University Hospitals of Leicester, Leicester, UK
Arch Dis Child 86:276-9. 2002Airway narrowing in acute bronchiolitis does not respond to inhaled bronchodilators but does to adrenaline when compared to bronchodilators. Influences of supportive care were not considered in previous treatment studies.
- [Success and failure predictors of non-invasive ventilation in acute bronchiolitis]J Mayordomo-Colunga
Seccion de Cuidados Intensivos Pediatricos, Hospital Universitario Central de Asturias, Oviedo, Espana
An Pediatr (Barc) 70:34-9. 2009The objective was to identify predictive factors for non-invasive ventilation (NIV) failure and to describe its use in bronchiolitis.
- A randomized, controlled trial of nebulized terbutaline for the first acute bronchiolitis in infants less than 12-months-oldFaten Tinsa
Department of Pediatrics B of the Children s Hospital of Tunis, Boulevard 9 avril, 1007 Jabbary, Tunis, Tunisia
Tunis Med 87:200-3. 2009Despite the common clinical practice, the available evidence on the efficacy of bronchodilators therapy for bronchiolitis is conflicting...
- Right ventricular function in children with severe respiratory syncytial virus (RSV) bronchiolitisK Thorburn
Department of Pediatric Intensive Care, Royal Liverpool Children s Hospital Alder Hey, Liverpool, UK
Minerva Anestesiol 77:46-53. 2011..The aim of this study was to assess right ventricular function in children with severe RSV disease and to investigate an association with disease severity, myocardial damage, and hepatitis...
- Efficacy of nebulized epinephrine versus salbutamol in hospitalized infants with bronchiolitisP Bertrand
Department of Pediatrics, School of Medicine, Catholic University of Chile, Santiago, Chile
Pediatr Pulmonol 31:284-8. 2001We enrolled 30 infants (median age 3 months, range 1-12 months), hospitalized for bronchiolitis in a randomized double-blind trial, to examine the efficacy and safety of nebulized epinephrine compared to salbutamol...
- High risk for RSV bronchiolitis in late preterms and selected infants affected by rare disorders: a dilemma of specific preventionP Manzoni
Neonatology and NICU, S Anna Hospital, ASO OI Regina Margherita S Anna, Torino, Italy
Early Hum Dev 88:S34-41. 2012Respiratory syncytial virus (RSV) is the most frequent aetiologic agent that causes bronchiolitis and lower respiratory tract infection in infants...
- Incidence and predisposing factors for severe disease in previously healthy term infants experiencing their first episode of bronchiolitisPaola Papoff
Pediatric Emergency and Intensive Care, Department of Pediatrics, Sapienza University of Rome, Rome, Italy
Acta Paediatr 100:e17-23. 2011To determine the incidence and predisposing factors for severe bronchiolitis in previously healthy term infants <12 months of age experiencing their first episode of bronchiolitis.
- Efficacy of salbutamol and ipratropium bromide in the management of acute bronchiolitis--a clinical trialBulent Karadag
Division of Pediatric Pulmonology, Marmara University, Istanbul, Turkey
Respiration 76:283-7. 2008A wide range of drugs are commonly used to treat bronchiolitis, but evidence of their effectiveness is limited.
- Transient hyperphosphatasemia in an infant with bronchiolitis and pneumoniaSlavica Dodig
Srebrnjak Children s Hospital, Srebrnjak 100, HR 10000 Zagreb, Croatia
Eur J Med Res 13:536-8. 2008We present a case of benign transient hyperphosphatasemia in a 4-month-old infant with acute bronchiolitis and pneumonia...
- Gene expression of nucleic acid-sensing pattern recognition receptors in children hospitalized for respiratory syncytial virus-associated acute bronchiolitisCarolina Scagnolari
Department of Experimental Medicine, Virology Section, Sapienza University of Rome, Viale di Porta Tiburtina 28, 00185 Rome, Italy
Clin Vaccine Immunol 16:816-23. 2009..with respiratory syncytial virus (RSV) infection might explain the broad clinical spectrum of RSV-associated bronchiolitis in infants...
- Neurally triggered breaths reduce trigger delay and improve ventilator response times in ventilated infants with bronchiolitisKatherine C Clement
Division of Pediatric Critical Care Medicine, Department of Anesthesiology, University of North Carolina at Chapel Hill, 214 MacNider, CB 7221, Chapel Hill, NC 27599 7221, USA
Intensive Care Med 37:1826-32. 2011..We hypothesized that neurally triggered breaths would reduce trigger delay, ventilator response times, and work of breathing in pediatric patients with bronchiolitis.
- Risk factors for recurrent wheezing following acute bronchiolitis: a 12-month follow-upLorena Cifuentes
Ambulatory Service, Department of Pediatrics, School of Medicine, Catholic University of Chile, Lira 85, Santiago de Chile, 833 0074 Chile
Pediatr Pulmonol 36:316-21. 2003..of this study was to identify wheezing recurrences and related risk factors in two groups of infants with bronchiolitis: respiratory syncytial virus (RSV)+ and RSV- as determined by RSV enzyme immunoassay...
- US outpatient office visits for bronchiolitis, 1993-2004Jonathan M Mansbach
Department of Medicine, Children s Hospital Boston, MA 02115, USA
Ambul Pediatr 7:304-7. 2007To describe the clinical epidemiology of US outpatient visits for children younger than 2 years with bronchiolitis.
- An artificial neural network ensemble to predict disposition and length of stay in children presenting with bronchiolitisPaul Walsh
Department of Emergency Medicine, Kern Medical Center, Bakersfield, CA 93305, USA
Eur J Emerg Med 11:259-64. 2004..An ensemble is a 'committee' of neural networks that usually outperforms single neural networks. Bronchiolitis is a common manifestation of viral lower respiratory tract infection in infants and toddlers.
- Does respiratory syncytial virus subtype influences the severity of acute bronchiolitis in hospitalized infants?Nikolaos G Papadopoulos
Research Laboratories, 2nd Department of Pediatrics, University of Athens School of Medicine, 13 Levadias Str, Goudi 11527, Greece
Respir Med 98:879-82. 2004..It is still not clear whether clinical severity of acute bronchiolitis differs between the two subtypes...
- [Current management of acute bronchiolitis in Tunisia]Khaled Menif
Service de Reanimation, Pédiatrique Polyvalente Hôpital d Enfants de TunisPlace Bab Saadoun, Tunis
Tunis Med 85:665-8. 2007The purpose of this study was to assess the current management practices of acute bronchiolitis by tunisian paediatricians.
- RSV Upper Airway Infection and Otitis MediaJOAN E contact DURBIN; Fiscal Year: 2010..Syncytial Virus (RSV) is a major cause of lower respiratory tract infection in infants and the elderly, and bronchiolitis and pneumonia caused by RSV are the primary reason for hospitalization of young children...
- Biology and Pathologies of Type V CollagenDaniel S Greenspan; Fiscal Year: 2013..2) We previously found autoimmunity to the 11(V) collagen chain to predispose patients to obliterative bronchiolitis(OB), the fibroproliferative process responsible for rejection of >50% of lung transplants...
- Immune Mechanism of Rejection in Human Lung AllograftsThalachallour Mohanakumar; Fiscal Year: 2013DESCRIPTION (provided by applicant): Chronic rejection, clinically diagnosed as Bronchiolitis obliterans Syndrome (BOS), is the most significant long term cause of morbidity and mortality following human lung transplantation (LTx)...
- Novel Means to Establish Free Radical Balance in the Neonatal Premature LungPrakash Jagtap; Fiscal Year: 2011..profound effects on quality of life and necessitating frequent and lifelong hospitalizations for pneumonia and bronchiolitis. Our current understanding of RDS and BPD is consistent with a mechanism of injury produced by an excess of O2-..
- Mechanisms and Enviromental Determinants of Rhinovirus Illness SeverityJames E Gern; Fiscal Year: 2013..have demonstrated that rhinovirus (HRV) is an important cause of lower respiratory illness including bronchiolitis, influenza-like illness, and exacerbations of chronic lung diseases such as asthma, cystic fibrosis, and ..
- Role of TLR-4 in Lung Reperfusion InjuryMICHAEL SCOTT MULLIGAN; Fiscal Year: 2013..transplant recipients and leads to enhanced MHC class II expression, acute graft dysfunction, earlier onset of bronchiolitis obliterans and increased recipient mortality...
- Single RNA sensitive probes for studying viral replication and buddingPhilip J Santangelo; Fiscal Year: 2013..RELEVANCE: Human respiratory syncytial virus (hRSV), an RNA virus, is the leading cause of viral pneumonia, bronchiolitis, respiratory failure, mechanical ventilation, and viral death in infants in the USA and worldwide, and causes ..
- The Role of Complement in Airway Microvascular DiseaseMARK ROBERT NICOLLS; Fiscal Year: 2013..vasculature in lung allografts may be critical for preventing terminal airway fibrosis, also known as the bronchiolitis obliterans syndrome...
- A Mucosal RSV VaccineKejian Yang; Fiscal Year: 2013..RSV infection is the leading cause of pulmonary disease of the lower respiratory tract (bronchiolitis, pneumonia and respiratory failure) in infants due to virus-induced airway damage and complex inflammatory ..
- Antiviral activity of leflunomide against respiratory syncytial virusWILLIAM WALDMAN; Fiscal Year: 2009..aims of this investigation are to test the hypothesis that leflunomide reduces RSV viral load and associated bronchiolitis in vivo, and to elucidate its antiviral mechanisms at the moleclular level...
- Development of Nanotherapeutics for RSV-induced Lung DiseaseShyam S Mohapatra; Fiscal Year: 2013..RSV is an opportunistic human respiratory pathogen that causes bronchiolitis in infants and pneumonia in immunocompromised adults and the elderly with an estimated 64 million infections ..
- TH17 Autoimmunity to Type V Collagen in Heart and Lung TransplantDavid S Wilkes; Fiscal Year: 2013..a component of normal extracellular matrix (ECM) and the process of chronic rejection, known as obliterative bronchiolitis in lung transplants recipients...
- Eicosanoid Balance in Lung Transplant Injury and RepairDavid Pinsky; Fiscal Year: 2009..lung graft failure occurs in up to 20% of recipients, and by 5 years, over half of all patients develop bronchiolitis obliterans (BO), the major cause of death outside of infections...
- TSLP and Childhood AsthmaSteven F Ziegler; Fiscal Year: 2012..However, 1-2% of previously healthy full term infants require hospitalization for RSV bronchiolitis. Several studies have shown that these children are at increased risk for subsequent wheezing or asthma for up ..
- Role of Calcium-Activated Chloride Channels in Airway Disease PhenotypesANAND CHAMPAK PATEL; Fiscal Year: 2011..Studies will be performed in vivo using our mouse models of viral bronchiolitis and allergen challenge and in vitro using primary-culture mouse airway epithelial cells grown at air-liquid ..
- Absorption, distribution, metabolism, excretion (ADME) of chemicals in mammalsRochelle W Tyl; Fiscal Year: 2009..of toxicity;2,3-butanedione;diacetyl;N,N-dimethylacetoacetamide;obliterative bronchiolitis;CYP;eugenol;safrole;estragole;anethole;myristicin;isosafrole;isoeugenol;methyleugenol;1,3-dichloro-2-propanol;..
- Role of epithelial HLA-G in lung transplantationSteven R White; Fiscal Year: 2010..Chronic allograft rejection (bronchiolitis obliterans syndrome, or BOS) is the major limitation to long-term survival, yet its pathogenesis is poorly ..
- Role of IL-17 in the Induction of Epithelial to Mesenchymal TransitionRagini Vittal; Fiscal Year: 2013..in fibrotic diseases, such as idiopathic pulmonary fibrosis (IPF) and lung transplant associated obliterative bronchiolitis (OB)...
- Whole Genome Association Analysis of Hematopoietic Cell Transplant (HCT) OutcomeJOHN ANDREW HANSEN; Fiscal Year: 2013..analyzed will include acute and chronic GVHD, immunological tolerance, airflow obstruction (AFO disease/bronchiolitis obliterans syndrome (BOS), acute kidney injury (AKI), Gram negative bacteremia, invasive fungal disease, CMV ..
- Novel Cellular Immune Profiles to Predict Lung Disease OutcomesScott M Palmer; Fiscal Year: 2012..Our application focuses on bronchiolitis obliterans syndrome (BOS), a fibrotic disease that occurs after human lung transplantation and is the primary ..
- Bronchoalveolar Lavage Cell Biomarkers in Lung RejectionMarshall I Hertz; Fiscal Year: 2010..those of kidney, heart, and liver recipients, largely due to the effects of acute and chronic lung rejection (bronchiolitis obliterans syndrome, BOS)...
- Studies to Evaluate the Toxic Carcinogenic Potential of Test AgentsJEFFERY DILL; Fiscal Year: 2009..ABAs have been linked to occupational exposure and human health effects including bronchiolitis obliterans. Animal studies are neede to determine the potential for human health effects to individual ABAs...
- SP-D as an immunomodulatory protein in acute rejection in lung transplantationKAREN D SIMS; Fiscal Year: 2010..rejection (ACR) affects 50% of recipients in the first year, and is a risk factor for the development of bronchiolitis obliterans syndrome, the leading cause of death in lung transplant recipients...
- Role of T Regulatory Cells in Preventing Human BOSAric L Gregson; Fiscal Year: 2013..Long-term survival is largely dependent upon recipients remaining free of bronchiolitis obliterans syndrome (BOS)...
- Genetic Analysis of Airflow Obstruction After Stem Cell TransplantationJoan G Clark; Fiscal Year: 2013..Known as bronchiolitis obliterans syndrome in its severest form, this syndrome is now estimated to affect up to 26% of patients who ..
- ALLOANTIBODIES TO MHC INDUCES AUTOIMMUNITY AND OBLITERATIVE AIRWAY DISEASE (OAD)Thalachallour Mohanakumar; Fiscal Year: 2012..However, long-term survival of the lung allograft is limited by the development of bronchiolitis obliterans syndrome (BOS), a condition unresponsive to therapy and often fatal...
- Studies to Evaluate the Toxic Carcinogenic Potential of Test AgentsJEFFERY DILL; Fiscal Year: 2010..ABAs have been linked to occupational exposure and human health effects including bronchiolitis obliterans. Animal studies are needed to determine the potential for human health effects to individual ABAs...
- Studies to Evaluate the Toxic Carcinogenic Potential of Test AgentsJEFFERY DILL; Fiscal Year: 2011..ABAs have been linked to occupational exposure and human health effects including bronchiolitis obliterans. Animal studies are needed to determine the potential for human health effects to individual ABAs...
- INNATE IMMUNE REGULATION OF PRIMARY GRAFT DYSFUNCTIONHoward J Huang; Fiscal Year: 2013..Importantly, PGD is also a risk factor for developing Bronchiolitis Obliterans Syndrome, the main cause of late graft failure and death in this population...
- TREATMENT OF ANTI-HLA ANTIBODIES TO PREVENT BOS AFTER LUNG TRANSPLANTATIONRoger D Yusen; Fiscal Year: 2011DESCRIPTION (provided by applicant): Chronic rejection or bronchiolitis obliterans syndrome (BOS) has emerged as the primary obstacle to long- term survival after lung transplantation...
- Adenosine 2A Receptor Signaling in Lung Transplant Injury and RejectionChristine L Lau; Fiscal Year: 2013..Importantly, IRI is a significant risk factor for the development of chronic allograft rejection, bronchiolitis obliterans (BO). Evidence supports alloimmune-dependent and alloimmune-independent factors in the etiology BO...
- Role of the Respiratory Syncytial Virus Fusion Protein in Airway Mucus InductionMARTIN LAWRENCE MOORE; Fiscal Year: 2013..In contrast to laboratory RSV strains, RSV strains line 19 and 2-20 induce mucus and bronchiolitis in mice...
- The Role of TLR4 and RSV F Protein in Immunity to RSVJORGE C BLANCO; Fiscal Year: 2013..Respiratory syncytial virus (RSV) is the leading cause of pneumonia and bronchiolitis in infants and young children worldwide, and has recently been attributed to increased morbidity and mortality ..
- Host Defense Mechanisms in Chronic Lung DiseaseJo Rae Wright; Fiscal Year: 2010..consists of four interrelated research projects that are focused on two chronic lung diseases: asthma and bronchiolitis obliterans syndrome (BOS) with a common underlying theme of epithelial injury, inflammation, repair and ..
- Research on inhalation toxicology of environmental chemicalsROBERT O apos CONNER; Fiscal Year: 2010..Recent work includes studies of bronchiolitis obliterans caused by inhalation of artificial butter flavoring components, mechanisms of pleural fibrosis ..
- Research on inhalation toxicology of environmental chemicalsROBERT O'CONNER; Fiscal Year: 2011..Recent work includes studies of bronchiolitis obliterans caused by inhalation of artificial butter flavoring components, mechanisms of pleural fibrosis ..
- Elafin Therapy for Lung DiseasesMarlene Rabinovitch; Fiscal Year: 2013..the microcirculation in the murine tracheal transplant model, and prevent airway ischemia associated with bronchiolitis obliterans...
- Molecular basis for paramyxovirus entryAnne Moscona; Fiscal Year: 2013..by the human paramyxovirus parainfluenza virus (HPIV) causes major respiratory diseases, including croup, bronchiolitis and pneumonia, which lead to illness or death in millions of infants and young children worldwide...
- Development of CMV-specific T Cell Memory in Lung Transplant RecipientsJohn F McDyer; Fiscal Year: 2012..Active CMV infection is associated with acute and chronic rejection (bronchiolitis obliterans syndrome), with donor+/recipient- (D+R-) mismatched lung transplant recipients (LTRs) at highest ..
- Molecular basis for paramyxovirus entryAnne Moscona; Fiscal Year: 2012..by the human paramyxovirus parainfluenza virus (HPIV) causes major respiratory diseases, including croup, bronchiolitis and pneumonia, which lead to illness or death in millions of infants and young children worldwide...
- Research on inhalation toxicology of environmental chemicalsROBERT O apos CONNER; Fiscal Year: 2009..Recent work includes studies of bronchiolitis obliterans caused by inhalation of artificial butter flavoring components, mechanisms of pleural fibrosis ..
- Developing Quality Measures to Assess Pediatric Inpatient Respiratory CareRita Mangione-Smith; Fiscal Year: 2013..a detailed assessment of inpatient management for children treated for six respiratory conditions: asthma, bronchiolitis, croup, pneumonia, congenital lung malformations, and cystic fibrosis...
- Matrix Metalloproteinase-8 in Obliterative Bronchiolitis Post Lung TransplantMeera Subramaniam; Fiscal Year: 2010Obliterative bronchiolitis (OB) is a process of chronic rejection after lung transplantation and is a major challenge for long-term survival...
- Vitamin D deficiency and the severity of bronchiolitisJonathan M Mansbach; Fiscal Year: 2012..Camargo, MD, DrPH, conducting bronchiolitis research...
- Molecular and Cellular Interactions Between Cigarette Smoke Exposure and RSV Charles S Dela Cruz; Fiscal Year: 2013..Respiratory syncytial virus (RSV) causes severe bronchiolitis in infants and worsens disease course in chronic obstructive lung disease (COPD) exacerbation in adults...
- Human Host Responses to Respiratory Syncytial Virus InfectionNATALIE THORNBURG; Fiscal Year: 2010..In the U.S., RSV can be detected in 43% of pediatric patients hospitalized with bronchiolitis and 25% with pneumonia...
- Prospective Cohort Study of Severe Bronchiolitis and Risk of Recurrent WheezingCarlos A Camargo; Fiscal Year: 2013DESCRIPTION (provided by applicant): Bronchiolitis is the most common cause of infant hospitalization in the US...
- Immune Mediated Disorders After Allogeneic Hematopoietic Cell Transplants (HCT)Stephanie J Lee; Fiscal Year: 2013..but poorly understood syndromes with particularly high morbidity/mortality: cutaneous sclerosis, bronchiolitis obliterans syndrome and late acute GVHD...
- Structural studies of respiratory syncytial virusElizabeth R Wright; Fiscal Year: 2013..To answer these questions, we are using the A2 strain of RSV that causes bronchiolitis, viral pneumonia, and death in young children, the elderly, and immuno-compromised individuals...
- Epidemiology and Etiology of Hospitalized Pneumonia in ChildrenKrow Ampofo; Fiscal Year: 2013..study to identify viral and bacterial pathogens which cause community-acquired pneumonia and complicated bronchiolitis in hospitalized children...
- Immune Mediated Disorders After Allogeneic Hematopoietic Cell Transplants (HCT)Stephanie J Lee; Fiscal Year: 2010..but poorly understood syndromes with particularly high morbidity/mortality: cutaneous sclerosis, bronchiolitis obliterans syndrome and late acute GVHD...
- A Critical Role for the Microvasculature in Airway TransplantationMARK ROBERT NICOLLS; Fiscal Year: 2013..microvasculature in lung allografts could be key for preventing terminal airway fibrosis, also known as the bronchiolitis obliterans syndrome (BOS)...
- NEUROGENIC INFLAMMATORY RESPONSE TO RSVGiovanni Piedimonte; Fiscal Year: 2013..brain-derived neurotrophic factors (BDNF)] and trkA receptors in the lower airways of human infants with RSV bronchiolitis. We also found that the recruitment of lymphocytes and monocytes to infected airways is amplified by ..
- Indoleamine 2,3-dioxygenase protective role in lung transplantationGary A Visner; Fiscal Year: 2010..Acute and chronic rejection/bronchiolitis obliterans (BO) are major limiting factors for long-term lung allograft survival with chronic rejection coming ..
- Prospective Multicenter Study of Bronchiolitis Admissions: Etiology & DispositionCarlos A Camargo; Fiscal Year: 2010DESCRIPTION (provided by applicant): Specific Aims: Bronchiolitis is the leading cause of hospitalization for infants, but there is a lack of consensus about optimal management...
- Why Are Steroids Ineffective at Suppressing RSV BronchiolitisRaymond J Pickles; Fiscal Year: 2013..These histologic findings are remarkably similar to those found in airways of human infants with RSV bronchiolitis and suggest PIV- mediated RSV NS2 expression in hamster bronchioles represent a novel animal model for ..
- Epithelial Cell Bactercidal/Permeability Increasing Protein in Lung InjuryJoan G Clark; Fiscal Year: 2010..infection and LPS expression are common in chronic airway disease such as asthma, cystic fibrosis, and chronic bronchiolitis. Delineation of BPI as a molecular modifier of airway infections and inflammation could form the basis for ..
- Syndecan-1 in Lung RepairPeter Chen; Fiscal Year: 2013..g., asthma remodeling, COPD, obliterative bronchiolitis, bronchiectasis)...
- Balance of Type 1 and 17 T cell Responses in Airway Rejection: The Role of T-betELIZABETH ANN LENDERMON; Fiscal Year: 2011..However, obliterative bronchiolitis (OB), or chronic airway rejection, limits its long-term success and occurs despite calcineurin-inhibitor based ..
- IL-17 and Lung Transplant Obliterative BronchiolitisRebecca A Shilling; Fiscal Year: 2013..50% for lung transplant patients is much lower compared to other solid organs due to the late complication of bronchiolitis obliterans syndrome for which there is no effective treatment...
- Mentored Patient Oriented Research in Lung TransplantationJason D Christie; Fiscal Year: 2013..response pre- operatively, and that these molecular mechanisms of lung injury in PGD are linked to subsequent bronchiolitis obliterans syndrome (BOS) risk...
- Midcareer Investigator Patient-oriented Research Award in Bronchiolitis &AsthmaTina V Hartert; Fiscal Year: 2013..caused by viruses such as respiratory syncytial virus (RSV) and rhinovirus (RV), are a leading cause of bronchiolitis in infants...
- Spatially Accurate Deformable Image Registration for Thoracic C ApplicationsThomas M Guerrero; Fiscal Year: 2013..They are unable to find air-trapping due to bronchiolitis alone...
- Nasal dosimetry of diacetyl and butyric acid vaporsJohn Morris; Fiscal Year: 2005..generally recognized as safe as food additives, exposure of workers to these vapors is associated with bronchiolitis obliterans...
- UVA Asthma and Allergic Diseases CenterThomas Platts Mills; Fiscal Year: 2005..studies on the role of viral infections in asthma by studying infants and children hospitalized for asthma/bronchiolitis and by defining the role of pre-existing inflammation and IgE antibody (Ab) in the response to rhinoviral ..
- Innovative Methods for Immune Tolerance in Lung Transpl*David Wilkes; Fiscal Year: 2003..The leading cause of death in lung allograft recipients is chronic rejection known as bronchiolitis obliterans (BO), and repeated acute rejection episodes are believed to culminate in BO...
- ASTHMA AND ALLERGIC DISEASES CENTERThomas Platts Mills; Fiscal Year: 2000..RSV in infancy is the most common cause of bronchiolitis. The G and F proteins will be used to investigate T cell responses in children who have been infected with RSV...
- RESPIRATORY SYNCYTIAL VIRUS BRONCHIOLITIS IN SHEEPArlene Stecenko; Fiscal Year: 1991Respiratory syncytial virus (RSV) is the most common cause of pneumonia and bronchiolitis in infancy. After an episode of RSV bronchiolitis severe enough to require hospitalization, 20-40% of infants develop asthma...
- IMMUNE REGULATION IN LUNG TRANSPLANTATIONWILLIAM BURLINGHAM; Fiscal Year: 2003..trial including patients from the UW-Madison is underway to see if a form of rapamycin (RAD) can prevent bronchiolitis obliterans syndrome (BOS) while improving long-term outcome in lung transplants...
- CHEMOKINE BIOLOGY IN BRONCHIOLITIS OBLITERANS SYNDROMEJohn Belperio; Fiscal Year: 2005Adapted from applicant's abstract) Chronic lung allograft rejection, Bronchiolitis Obliterans Syndrome (BOS) is a chronic process that demonstrates features of dysregulated and aberrant repair of airways...