bronchiolitis

Summary

Summary: Inflammation of the bronchioles.

Top Publications

  1. ncbi Bronchiolitis
    Rosalind L Smyth
    Division of Child Health, School of Reproductive and Developmental Medicine, University of Liverpool, Alder Hey Children s Hospital, Liverpool L12 2AP, UK
    Lancet 368:312-22. 2006
  2. ncbi Respiratory bronchiolitis: a clinicopathologic study in current smokers, ex-smokers, and never-smokers
    Mostafa Fraig
    Department of Pathology, Upstate Medical University, Syracuse, New York, USA
    Am J Surg Pathol 26:647-53. 2002
  3. ncbi Association between common Toll-like receptor 4 mutations and severe respiratory syncytial virus disease
    Guy Tal
    Pediatric Pulmonary Unit, Edith Wolfson Medical Center, Tel Aviv University, Holon, Israel
    J Infect Dis 189:2057-63. 2004
  4. pmc Prospective multicenter study of viral etiology and hospital length of stay in children with severe bronchiolitis
    Jonathan M Mansbach
    Department of Medicine, Children s Hospital Boston, Boston 02115, USA
    Arch Pediatr Adolesc Med 166:700-6. 2012
  5. pmc Risk factors in children hospitalized with RSV bronchiolitis versus non-RSV bronchiolitis
    Carla G García
    Department of Pediatrics, Division of Pediatric Infectious Diseases, University of Texas Southwestern Medical Center, Texas, USA
    Pediatrics 126:e1453-60. 2010
  6. ncbi Review of epidemiology and clinical risk factors for severe respiratory syncytial virus (RSV) infection
    Robert C Welliver
    Department of Pediatrics, State University of New York at Buffalo, School of Medicine and Biomedical Sciences, and the Division of Infectious Diseases, Children s Hospital of Buffalo, New York 14222, USA
    J Pediatr 143:S112-7. 2003
  7. ncbi The impact of dual viral infection in infants admitted to a pediatric intensive care unit associated with severe bronchiolitis
    Nathalie Richard
    Service d urgence et de réanimation pédiatriques, Hopital Edouard Herriot, Lyon, France
    Pediatr Infect Dis J 27:213-7. 2008
  8. ncbi Cord blood vitamin D deficiency is associated with respiratory syncytial virus bronchiolitis
    Mirjam E Belderbos
    Department of Pediatrics, University Medical Center Utrecht, Utrecht
    Pediatrics 127:e1513-20. 2011
  9. pmc Parental and household smoking and the increased risk of bronchitis, bronchiolitis and other lower respiratory infections in infancy: systematic review and meta-analysis
    Laura L Jones
    UK Centre for Tobacco Control Studies, Division of Epidemiology and Public Health, University of Nottingham, Clinical Sciences Building, Nottingham City Hospital, Nottingham, NG5 1PB, UK
    Respir Res 12:5. 2011
  10. ncbi Evaluation of the utility of radiography in acute bronchiolitis
    Suzanne Schuh
    Division of Paediatric Emergency Medicine, Department of Pediatrics, Research Institute, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada
    J Pediatr 150:429-33. 2007

Research Grants

  1. RSV Upper Airway Infection and Otitis Media
    JOAN E contact DURBIN; Fiscal Year: 2010
  2. Biology and Pathologies of Type V Collagen
    Daniel S Greenspan; Fiscal Year: 2013
  3. Immune Mechanism of Rejection in Human Lung Allografts
    Thalachallour Mohanakumar; Fiscal Year: 2013
  4. Novel Means to Establish Free Radical Balance in the Neonatal Premature Lung
    Prakash Jagtap; Fiscal Year: 2011
  5. Mechanisms and Enviromental Determinants of Rhinovirus Illness Severity
    James E Gern; Fiscal Year: 2013
  6. Role of TLR-4 in Lung Reperfusion Injury
    MICHAEL SCOTT MULLIGAN; Fiscal Year: 2013
  7. Single RNA sensitive probes for studying viral replication and budding
    Philip J Santangelo; Fiscal Year: 2013
  8. The Role of Complement in Airway Microvascular Disease
    MARK ROBERT NICOLLS; Fiscal Year: 2013
  9. A Mucosal RSV Vaccine
    Kejian Yang; Fiscal Year: 2013
  10. Antiviral activity of leflunomide against respiratory syncytial virus
    WILLIAM WALDMAN; Fiscal Year: 2009

Detail Information

Publications285 found, 100 shown here

  1. ncbi Bronchiolitis
    Rosalind L Smyth
    Division of Child Health, School of Reproductive and Developmental Medicine, University of Liverpool, Alder Hey Children s Hospital, Liverpool L12 2AP, UK
    Lancet 368:312-22. 2006
    b>Bronchiolitis is a distressing, potentially life-threatening respiratory condition that affects young babies...
  2. ncbi Respiratory bronchiolitis: a clinicopathologic study in current smokers, ex-smokers, and never-smokers
    Mostafa Fraig
    Department of Pathology, Upstate Medical University, Syracuse, New York, USA
    Am J Surg Pathol 26:647-53. 2002
    The clinical and pathologic features of 109 cases of respiratory bronchiolitis (RB) identified from review of 156 consecutive surgical lung biopsy specimens were studied...
  3. ncbi Association between common Toll-like receptor 4 mutations and severe respiratory syncytial virus disease
    Guy Tal
    Pediatric Pulmonary Unit, Edith Wolfson Medical Center, Tel Aviv University, Holon, Israel
    J Infect Dis 189:2057-63. 2004
    The clinical spectrum of respiratory syncytial virus (RSV) bronchiolitis in previously healthy infants is extremely variable. Thus, it is likely that factors such as genetic heterogeneity contribute to disease severity...
  4. pmc Prospective multicenter study of viral etiology and hospital length of stay in children with severe bronchiolitis
    Jonathan M Mansbach
    Department of Medicine, Children s Hospital Boston, Boston 02115, USA
    Arch Pediatr Adolesc Med 166:700-6. 2012
    To determine whether hospital length of stay(LOS) for acute bronchiolitis is influenced by the infecting pathogen.
  5. pmc Risk factors in children hospitalized with RSV bronchiolitis versus non-RSV bronchiolitis
    Carla G García
    Department of Pediatrics, Division of Pediatric Infectious Diseases, University of Texas Southwestern Medical Center, Texas, USA
    Pediatrics 126:e1453-60. 2010
    The trends in hospitalization rates and risk factors for severe bronchiolitis have not been recently described, especially after the routine implementation of prophylaxis for respiratory syncytial virus (RSV) infections.
  6. ncbi Review of epidemiology and clinical risk factors for severe respiratory syncytial virus (RSV) infection
    Robert C Welliver
    Department of Pediatrics, State University of New York at Buffalo, School of Medicine and Biomedical Sciences, and the Division of Infectious Diseases, Children s Hospital of Buffalo, New York 14222, USA
    J Pediatr 143:S112-7. 2003
    ..Pulmonary hypertension and cyanosis are associated with worse outcomes in infants with congenital heart disease, and prolonged viral replication accounts for more severe illness in immunocompromised individuals...
  7. ncbi The impact of dual viral infection in infants admitted to a pediatric intensive care unit associated with severe bronchiolitis
    Nathalie Richard
    Service d urgence et de réanimation pédiatriques, Hopital Edouard Herriot, Lyon, France
    Pediatr Infect Dis J 27:213-7. 2008
    b>Bronchiolitis is a major cause of morbidity and mortality in early childhood worldwide. The presence of more than one pathogen may influence the natural history of acute bronchiolitis in infants.
  8. ncbi Cord blood vitamin D deficiency is associated with respiratory syncytial virus bronchiolitis
    Mirjam E Belderbos
    Department of Pediatrics, University Medical Center Utrecht, Utrecht
    Pediatrics 127:e1513-20. 2011
    ..Respiratory syncytial virus (RSV) is the most important pathogen causing severe lower respiratory tract infection (LRTI) in infants. Epidemiologic and basic studies suggest that vitamin D may protect against RSV LRTI...
  9. pmc Parental and household smoking and the increased risk of bronchitis, bronchiolitis and other lower respiratory infections in infancy: systematic review and meta-analysis
    Laura L Jones
    UK Centre for Tobacco Control Studies, Division of Epidemiology and Public Health, University of Nottingham, Clinical Sciences Building, Nottingham City Hospital, Nottingham, NG5 1PB, UK
    Respir Res 12:5. 2011
    ..aim of this paper is to provide an updated systematic review and meta-analysis of studies of the association between passive smoking and LRI, and with diagnostic subcategories including bronchiolitis, in infants aged two years and under.
  10. ncbi Evaluation of the utility of radiography in acute bronchiolitis
    Suzanne Schuh
    Division of Paediatric Emergency Medicine, Department of Pediatrics, Research Institute, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada
    J Pediatr 150:429-33. 2007
    To determine the proportion of radiographs inconsistent with bronchiolitis in children with typical presentation of bronchiolitis and to compare rates of intended antibiotic therapy before radiography versus those given antibiotics after ..
  11. ncbi Long-term airway morbidity following viral LRTI in early infancy: recurrent wheezing or asthma?
    Renato T Stein
    Departamento de Pediatria, Faculdade de Medicina, Pontificia Universidade Catolica, Porto Alegre, Brazil
    Paediatr Respir Rev 10:29-31. 2009
    ..Respiratory syncytial virus (RSV) is an agent especially associated with severe cases of bronchiolitis affecting young infants in winter months and has a typical seasonal pattern...
  12. ncbi Broad respiratory virus detection in infants hospitalized for bronchiolitis by use of a multiplex RT-PCR DNA microarray system
    Antoine Huguenin
    Medical and Molecular Virology Unit and EA 484, University Hospital Center and Medical School of Reims, Reims, France
    J Med Virol 84:979-85. 2012
    ..RT-PCR DNA microarray in diagnosis and epidemiological survey of viral infections in infants hospitalized for bronchiolitis was assessed...
  13. ncbi Infection with multiple viruses is not associated with increased disease severity in children with bronchiolitis
    H Kim Brand
    Department of Pediatrics, Radboud University Nijmegen Medical Centre, P O Box 9101, 6500 HB, Nijmegen, The Netherlands
    Pediatr Pulmonol 47:393-400. 2012
    ..This study evaluated the association between the detection of multiple viruses by RT-PCR and disease severity in children with bronchiolitis.
  14. ncbi The outcome after severe bronchiolitis is related to gender and virus
    Ingvild B Mikalsen
    Department of Pediatrics, Stavanger University Hospital, Stavanger, Norway
    Pediatr Allergy Immunol 23:391-8. 2012
    The association between bronchiolitis in the first year of life and subsequent asthma, atopy, airway obstruction and bronchial hyper-responsiveness (BHR) is unsettled...
  15. ncbi Specific increase in local IL-17 production during recovery from primary RSV bronchiolitis
    Tina E Faber
    Department of Pediatrics, Medical Center Leeuwarden, Leeuwarden, The Netherlands
    J Med Virol 84:1084-8. 2012
    Although Respiratory syncytial virus (RSV) bronchiolitis is the most important cause of hospital admission for infants during the winter season, the pathogenesis is largely unknown...
  16. ncbi Respiratory bronchiolitis-associated interstitial lung disease with fibrosis is a lesion distinct from fibrotic nonspecific interstitial pneumonia: a proposal
    Samuel A Yousem
    Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA 15213 2582, USA
    Mod Pathol 19:1474-9. 2006
    ..of clinical and radiographic chronic interstitial lung disease are presented that have features of respiratory bronchiolitis-associated interstitial lung disease, but were associated with a respiratory bronchiolitis having extensive ..
  17. pmc In very young infants severity of acute bronchiolitis depends on carried viruses
    Christophe Marguet
    Respiratory Diseases, Allergy and CF Unit, Pediatric Department, Rouen University Hospital Charles Nicolle, Rouen, France
    PLoS ONE 4:e4596. 2009
    RT amplification reaction has revealed that various single viruses or viral co-infections caused acute bronchiolitis in infants, and RV appeared to have a growing involvement in early respiratory diseases...
  18. ncbi Bronchiolitis: recent evidence on diagnosis and management
    Joseph J Zorc
    MSCE, Children s Hospital of Philadelphia, Division of Emergency Medicine, Main AS01, 34th Street and Civic Center Boulevard, Philadelphia, PA 19104 4399, USA
    Pediatrics 125:342-9. 2010
    Viral bronchiolitis is a leading cause of acute illness and hospitalization of young children...
  19. ncbi Functional genetic variation in NFKBIA and susceptibility to childhood asthma, bronchiolitis, and bronchopulmonary dysplasia
    Salman Ali
    Department of Pediatrics, British Columbia Children s Hospital and Child and Family Research Institute, University of British Columbia, Vancouver, British Columbia V6H 3V4, Canada
    J Immunol 190:3949-58. 2013
    ..relevant genetic variation in the promoter of NFKBIA is associated with differential susceptibility to severe bronchiolitis following infection with respiratory syncytial virus, airway hyperresponsiveness, and severe bronchopulmonary ..
  20. pmc Steroids and bronchodilators for acute bronchiolitis in the first two years of life: systematic review and meta-analysis
    Lisa Hartling
    Alberta Research Centre for Health Evidence, Department of Pediatrics, University of Alberta, 11402 University Avenue, Edmonton, AB, Canada T6G 2J3
    BMJ 342:d1714. 2011
    To evaluate and compare the efficacy and safety of bronchodilators and steroids, alone or combined, for the acute management of bronchiolitis in children aged less than 2 years.
  21. pmc Human metapneumovirus and lower respiratory tract disease in otherwise healthy infants and children
    John V Williams
    Division of Infectious Diseases, Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN 37232 2581, USA
    N Engl J Med 350:443-50. 2004
    ..We sought to determine the role of human metapneumovirus in lower respiratory tract illness in previously healthy infants and children...
  22. pmc Incidence and risk factors of hospitalization for bronchiolitis in preterm children: a retrospective longitudinal study in Italy
    Patrizio Pezzotti
    Agency for Public Health of Lazio Region, Scientific Direction Unit, Rome, Italy
    BMC Pediatr 9:56. 2009
    b>Bronchiolitis is a distressing, potentially life-threatening respiratory condition that affects infants. We evaluated the incidence and risk factors of hospitalization for broncholitis in preterm infants (i.e...
  23. ncbi The polymorphism of IL-17 G-152A was associated with childhood asthma and bacterial colonization of the hypopharynx in bronchiolitis
    Jiehua Chen
    Division of Respiratory Medicine, Children s Hospital of Chongqing Medical University, Chongqing, 400014, China
    J Clin Immunol 30:539-45. 2010
    ..We investigated the association between single-nucleotide polymorphism (SNP) of IL-17 (rs2275913, IL-17 G-152A) and asthma-related traits. Its effect on IL-17 production was also attractive...
  24. ncbi Epinephrine and dexamethasone in children with bronchiolitis
    Amy C Plint
    Department of Pediatrics, University of Ottawa and Children s Hospital of Eastern Ontario, Ottawa, Canada
    N Engl J Med 360:2079-89. 2009
    Although numerous studies have explored the benefit of using nebulized epinephrine or corticosteroids alone to treat infants with bronchiolitis, the effectiveness of combining these medications is not well established.
  25. ncbi Persistence of rhinovirus and enterovirus RNA after acute respiratory illness in children
    Tuomas Jartti
    Department of Pediatrics, Turku University Hospital, Turku, Finland
    J Med Virol 72:695-9. 2004
    ..The study shows that after the onset of symptomatic respiratory infection enterovirus RNA may take 2-3 weeks and rhinovirus RNA 5-6 weeks to disappear from nasal mucus...
  26. ncbi Correlation of viral load of respiratory pathogens and co-infections with disease severity in children hospitalized for lower respiratory tract infection
    Anna Franz
    Department of Pediatrics, Heinrich Heine University Dusseldorf, Dusseldorf, Germany
    J Clin Virol 48:239-45. 2010
    ..The clinical significance of viral load and co-infections in children with respiratory infections is not clear...
  27. ncbi Bilateral bronchiectasis and bronchiolitis at thin-section CT: diagnostic implications in nontuberculous mycobacterial pulmonary infection
    Won Jung Koh
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Ilwon Dong, Kangnam Ku, Seoul 135 710, Korea
    Radiology 235:282-8. 2005
    ..of nontuberculous mycobacterial (NTM) pulmonary infection in patients with bilateral bronchiectasis and bronchiolitis at chest computed tomography (CT) and whether CT findings are indicative of Mycobacterium avium-intracellulare ..
  28. ncbi Clinical predictors of nasal continuous positive airway pressure requirement in acute bronchiolitis
    Jordan Evans
    Department of Paediatric Emergency Medicine, Chelsea and Westminster Hospital, London, UK
    Pediatr Pulmonol 47:381-5. 2012
    There is growing use of nasal continuous positive airway pressure ventilation (nCPAP) for infants with bronchiolitis, based on clinical assessment of severity...
  29. pmc Therapeutic approach to bronchiolitis: why pediatricians continue to overprescribe drugs?
    Daniele De Brasi
    Pediatric Unit, AORN A Cardarelli, Naples, Italy
    Ital J Pediatr 36:67. 2010
    b>Bronchiolitis guidelines suggest that neither bronchodilators nor corticosteroids, antiviral and antibacterial agents should be routinely used. Although recommendations, many clinicians persistently prescribe drugs for bronchiolitis.
  30. ncbi Lung ultrasound in bronchiolitis: comparison with chest X-ray
    Vito Antonio Caiulo
    Department of Pediatrics, Perrino Hospital, Piazza Angeli, 3 72100 Brindisi, Italy
    Eur J Pediatr 170:1427-33. 2011
    The diagnosis of bronchiolitis is based mainly on the patient's medical history and physical examination. However, in severe cases, a further evaluation including chest X-ray (CXR) may be necessary...
  31. ncbi Metabolomics in paediatric respiratory diseases and bronchiolitis
    Alessandra Atzei
    Neonatal Intensive Care Unit, Puericultura Institute and Neonatal Section, University of Cagliari, Italy
    J Matern Fetal Neonatal Med 24:59-62. 2011
    ..the application of clinical metabolomics in three different areas of respiratory diseases in pediatrics: asthma, pneumonia and bronchiolitis. Comparison between two 1H-NMR urine spectra by two bronchiolitis patients are also presented.
  32. ncbi [Rhinovirus and acute bronchiolitis in young infants]
    Paulo M C Pitrez
    Departamento de Pediatria, Pontificia Universidade Catolica do Rio Grande do Sul PUCRS, Porto Alegre, RS, Brazil
    J Pediatr (Rio J) 81:417-20. 2005
    To determine the prevalence of rhinovirus infection in hospitalized young infants with acute bronchiolitis.
  33. pmc Viral-mediated inhibition of antioxidant enzymes contributes to the pathogenesis of severe respiratory syncytial virus bronchiolitis
    Yashoda M Hosakote
    Department of Pediatrics, The University of Texas Medical Branch at Galveston, Galveston, TX 77555 0366, USA
    Am J Respir Crit Care Med 183:1550-60. 2011
    ..We have previously shown that RSV induces reactive oxygen species in cultured cells and oxidative injury in the lungs of experimentally infected mice. The mechanism(s) of RSV-induced oxidative stress in vivo is not known...
  34. pmc Reduced lung function both before bronchiolitis and at 11 years
    S W Turner
    University Department of Paediatrics, Princess Margaret Hospital for Children, Perth, Australia
    Arch Dis Child 87:417-20. 2002
    We have previously shown an association between reduced premorbid lung function (V'maxFRC) and bronchiolitis. We hypothesised that individuals with bronchiolitis will go on to have reduced lung function and increased respiratory symptoms ..
  35. ncbi Macrophage impairment underlies airway occlusion in primary respiratory syncytial virus bronchiolitis
    Jennifer L Reed
    Respiratory, Inflammation, and Autoimmunity Group, MedImmune, Gaithersburg, Maryland, USA
    J Infect Dis 198:1783-93. 2008
    Although respiratory syncytial virus (RSV) infection is the most important cause of bronchiolitis in infants, the pathogenesis of RSV disease is poorly described...
  36. ncbi Bronchiolitis management before and after the AAP guidelines
    Kavita Parikh
    Division of Hospitalist Medicine, 111 Michigan Ave NW, Washington, DC 20010
    Pediatrics 133:e1-7. 2014
    Evidence-based practice guidelines for bronchiolitis management published by the American Academy of Pediatrics in 2006 recommend supportive care with limited diagnostic testing and treatment...
  37. ncbi Situs inversus totalis: the association of Kartagener's syndrome with diffuse bronchiolitis and azoospermia
    Vikas Mittal
    Department of Respiratory Medicine, Vallabhbhai Patel Chest Institute, University of Delhi, Delhi, India
    Arch Bronconeumol 48:179-82. 2012
    ..Association of diffuse bronchiolitis (DB) with KS has been documented from Japan only...
  38. ncbi Non-invasive ventilation for severe bronchiolitis: analysis and evidence
    Michaela R Lazner
    Department of Emergency Medicine, Sheffield Children s Hospital, Sheffield, UK
    Pediatr Pulmonol 47:909-16. 2012
    1) To examine whether infants with severe bronchiolitis, fulfilling criteria for further respiratory support, could be managed outside a Pediatric Intensive Care Unit (PICU) with non-invasive ventilation (NIV) alone...
  39. ncbi Chest physiotherapy for acute bronchiolitis in paediatric patients between 0 and 24 months old
    Marta Roqué I Figuls
    Iberoamerican Cochrane Centre, Institute of Biomedical Research IIB Sant Pau, Barcelona, CIBER Epidemiologia y Salud Pública CIBERESP, Spain, Barcelona, Spain
    Cochrane Database Syst Rev 2:CD004873. 2012
    This is an update of the original Cochrane review published in 2005 and updated in 2007. Acute bronchiolitis is the leading cause of medical emergencies during winter in children younger than two years of age...
  40. ncbi Bordetella pertussis infection attenuates clinical course of acute bronchiolitis
    Bahaa Abu Raya
    Department of Pediatrics, Bnai Zion Medical Center, Haifa, Israel
    Pediatr Infect Dis J 32:619-21. 2013
    ..The aim of this study was to assess clinical characteristics of BP infection, and its effect on disease severity in young children hospitalized with acute bronchiolitis.
  41. ncbi Comparison of the effects that two different respiratory physical therapy techniques have on cardiorespiratory parameters in infants with acute viral bronchiolitis
    Melissa Karina Pupin
    Departamento de Pediatria, Universidade Estadual de Campinas, Campinas, SP, Brasil
    J Bras Pneumol 35:860-7. 2009
    ..compare the expiratory flow increase technique (EFIT) and vibration accompanied by postural drainage (PD) in terms of their effects on the heart rate (HR), respiratory rate (RR) and SpO(2) of infants with acute viral bronchiolitis (AVB).
  42. pmc LDH concentration in nasal-wash fluid as a biochemical predictor of bronchiolitis severity
    Federico R Laham
    Baylor College of Medicine, Department of Pediatrics, One Baylor Plaza, Room 248E MS280, Houston, TX 77030, USA
    Pediatrics 125:e225-33. 2010
    Because the decision to hospitalize an infant with bronchiolitis is often supported by subjective criteria and objective indicators of bronchiolitis severity are lacking, we tested the hypothesis that lactate dehydrogenase (LDH), which ..
  43. ncbi Current therapy for bronchiolitis
    Prasad Nagakumar
    Department of Paediatric Respiratory Medicine Paediatric Cystic Fibrosis Centre, Children s Hospital for Wales, Cardiff, UK
    Arch Dis Child 97:827-30. 2012
    b>Bronchiolitis is a common, self-limiting, seasonal viral respiratory tract infection in infancy accounting for the majority of hospital admissions in this age group...
  44. pmc Randomized placebo-controlled trial on azithromycin to reduce the morbidity of bronchiolitis in Indigenous Australian infants: rationale and protocol
    Anne B Chang
    Child Health Division, Menzies School of Health Research, Charles Darwin University, Darwin, Northern Territory, Australia
    Trials 12:94. 2011
    ..Globally, bronchiolitis is the most common form of acute lower respiratory infections during infancy...
  45. ncbi Bronchiolitis-associated hospitalizations among US children, 1980-1996
    D K Shay
    Respiratory and Enteric Viruses Branch, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    JAMA 282:1440-6. 1999
    Respiratory syncytial virus (RSV) causes more lower respiratory tract infections, often manifested as bronchiolitis, among young children than any other pathogen...
  46. ncbi The overlap between respiratory bronchiolitis and desquamative interstitial pneumonia in pulmonary Langerhans cell histiocytosis: high-resolution CT, histologic, and functional correlations
    Robert Vassallo
    Thoracic Diseases Research Unit, Division of Pulmonary, Critical Care and Internal Medicine, Mayo Clinic and Foundation, Rochester, MN 55905, USA
    Chest 124:1199-205. 2003
    To characterize the histologic, high-resolution CT (HRCT), and functional correlates of respiratory bronchiolitis (RB)/desquamative interstitial pneumonia (DIP)-like changes in biopsy specimens of adults with pulmonary Langerhans cell ..
  47. ncbi Infant swimming in chlorinated pools and the risks of bronchiolitis, asthma and allergy
    C Voisin
    Dept of Public Health, Catholic University of Louvain, Louvain, Belgium
    Eur Respir J 36:41-7. 2010
    ..The aim of the present study was to assess the influence of swimming in chlorinated pools on the risks of bronchiolitis and its late consequences. A total of 430 children (47% female; mean age 5...
  48. ncbi Duration of illness in infants with bronchiolitis evaluated in the emergency department
    Frank D Petruzella
    Division of Emergency Medicine, Department of Pediatrics, Medical College of Wisconsin, Milwaukee, Wisconsin, USA
    Pediatrics 126:285-90. 2010
    To describe the duration of illness in infants with first-time bronchiolitis who present to an emergency department (ED) and assess the burden of the illness on caregivers and families.
  49. ncbi Nebulized 5% or 3% hypertonic or 0.9% saline for treating acute bronchiolitis in infants
    Khalid Al-Ansari
    Division of Pediatric Emergency Medicine, Department of Pediatrics, Hamad Medical Corporation, Doha, Qatar
    J Pediatr 157:630-4, 634.e1. 2010
    To compare the efficacy and safety of 5%, 3%, and 0.9% saline solution for treating acute bronchiolitis in the prehospital setting.
  50. ncbi Severe chronic bronchiolitis as the presenting feature of primary Sjögren's syndrome
    Raphael Borie
    Assistance Publique Hopitaux de Paris, Hopital Bichat, Service de Pneumologie A, Centre de Compétence maladies rares pulmonaires, Paris, France
    Respir Med 105:130-6. 2011
    ..We describe here 5 patients with severe chronic bronchiolitis revealing primary Sjögren's syndrome...
  51. pmc Characterization of the resistance of SJL/J mice to pneumonia virus of mice, a model for infantile bronchiolitis due to a respiratory syncytial virus
    Stéphanie Glineur
    Department of Morphology and Pathology, College of Veterinary Medicine, University of Liege, Sart Tilman, Belgium
    PLoS ONE 7:e44581. 2012
    ....
  52. ncbi Sustaining the implementation of an evidence-based guideline for bronchiolitis
    P H Perlstein
    Division of Health Policy and Clinical Effectiveness, Children s Hospital Medical Center, Cincinnati, OH, USA
    Arch Pediatr Adolesc Med 154:1001-7. 2000
    To describe the changes occurring over a 3-year period after implementation of an evidence-based clinical practice guideline for the care of infants with bronchiolitis.
  53. ncbi Bronchiolitis management in pediatric emergency departments in Australia and New Zealand: a PREDICT study
    Franz E Babl
    Emergency Department, Royal Children s Hospital, Melbourne, Vic, Australia
    Pediatr Emerg Care 24:656-8. 2008
    b>Bronchiolitis is the most frequent reason for admission in infants...
  54. ncbi HLA-specific antibodies are risk factors for lymphocytic bronchiolitis and chronic lung allograft dysfunction
    Alin L Girnita
    Department of Pathology, University of Pittsburgh, Pittsburgh, PA, USA
    Am J Transplant 5:131-8. 2005
    b>Bronchiolitis obliterans syndrome (BOS) represents a major limitation in lung transplantation. While acute rejection is widely considered the most important risk factor for BOS, the impact of HLA-specific antibodies is less understood...
  55. pmc Increasing burden and risk factors for bronchiolitis-related medical visits in infants enrolled in a state health care insurance plan
    Kecia N Carroll
    Department of Pediatrics, Division of General Pediatrics, Child and Adolescent Health Research Unit, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 8300, USA
    Pediatrics 122:58-64. 2008
    The goals were to estimate the year-round burden of health care visits attributable to bronchiolitis and to identify risk factors for bronchiolitis in term healthy infants.
  56. pmc Lymphocyte apoptosis in acute respiratory syncytial virus bronchiolitis
    M F E Roe
    Department of Paediatrics, University of Cambridge, Cambridge, UK
    Clin Exp Immunol 137:139-45. 2004
    ..RSV bronchiolitis in infants is associated with a transient decline in circulating lymphocytes...
  57. ncbi Pharmacologic treatment of bronchiolitis in infants and children: a systematic review
    Valerie J King
    Cecil B Sheps Center for Health Services Research, University of North Carolina at Chapel Hill, 725 Airport Road, Campus Box 7590, Chapel Hill, NC 27599 7595, USA
    Arch Pediatr Adolesc Med 158:127-37. 2004
    b>Bronchiolitis is the most common lower respiratory tract infection in infants. Up to 3% of all children in their first year of life are hospitalized with bronchiolitis...
  58. ncbi Descriptive epidemiological features of bronchiolitis in a population-based cohort
    Mieke Koehoorn
    School of Environmental Health, Centre for Health Services and Policy Research, University of British Columbia, 5804 Fairview Ave, Vancouver, British Columbia, Canada V6T 1Z3
    Pediatrics 122:1196-203. 2008
    The goal was to investigate the epidemiological features of incident bronchiolitis by using a population-based infant cohort.
  59. ncbi Risk factors for bronchiolitis-associated deaths among infants in the United States
    Robert C Holman
    Respiratory and Enteric Viruses Branch, Division of Viral and Ricksettial Diseases, National Center for Infectious Diseases, Center for Disease Control and Prevention DHHS, Atlanta, GA 30333, USA
    Pediatr Infect Dis J 22:483-90. 2003
    Risk factors for bronchiolitis deaths have not been described on a national level. We examined the epidemiology of and identified risk factors for bronchiolitis-associated deaths among infants in the United States.
  60. ncbi Bronchiolitis in infants
    H B Panitch
    University of Pennsylvania School of Medicine, Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
    Curr Opin Pediatr 13:256-60. 2001
    b>Bronchiolitis is a common cause of wheezing among infants...
  61. ncbi Diagnosis and testing in bronchiolitis: a systematic review
    W Clayton Bordley
    Departments of Pediatrics and Surgery, Division of Emergency Medicine, Duke University Medical Center, DUMC Box 3096, Durham, NC 27710, USA
    Arch Pediatr Adolesc Med 158:119-26. 2004
    The diagnosis of bronchiolitis is based on typical history and results of a physical examination...
  62. ncbi Influence of ambient air pollutant sources on clinical encounters for infant bronchiolitis
    Catherine J Karr
    Department of Pediatrics, University of Washington, 401 Broadway, Box 359739, Seattle, WA 98104, USA
    Am J Respir Crit Care Med 180:995-1001. 2009
    Data regarding the influence of ambient air pollution on infant bronchiolitis are few.
  63. ncbi Risks of severity and readmission of Indigenous and non-Indigenous children hospitalised for bronchiolitis
    Emily J Bailey
    Queensland Children s Respiratory Centre, Royal Children s Hospital, Brisbane, QLD, Australia
    J Paediatr Child Health 45:593-7. 2009
    To describe the characteristics of children admitted to Royal Darwin Hospital with bronchiolitis, and to compare the severity of illness and incidence of subsequent readmission in Indigenous and non-Indigenous children.
  64. ncbi Respiratory syncytial virus infection and immunoprophylaxis for selected high-risk children in Central Australia
    Srinivas Bolisetty
    Department of Paediatrics, Alice Springs Hospital, Alice Springs, Australia
    Aust J Rural Health 13:265-70. 2005
    There are limited data on the epidemiology and viral aetiology of bronchiolitis in Central Australia and respiratory syncytial virus (RSV) immunoprophylaxis in an Australian population.
  65. ncbi Direct medical costs of bronchiolitis hospitalizations in the United States
    Andrea J Pelletier
    EMNet Coordinating Center, Department of Emergency Medicine, Massachusetts General Hospital, 326 Cambridge St, 4th Floor, Boston, MA 02114, USA
    Pediatrics 118:2418-23. 2006
    Although bronchiolitis is the leading cause of hospitalization for infants, there are limited data describing the epidemiology of bronchiolitis hospitalizations, and the associated cost is unknown...
  66. ncbi [Effects of nasal continuous positive airway pressure ventilation in infants with severe acute bronchiolitis]
    S Larrar
    Assistance Publique Hopitaux de Paris, Service de Réanimation Pédiatrique, Hopital de Bicetre, 78, rue du General Leclerc, 94270 Le Kremlin Bicetre, France
    Arch Pediatr 13:1397-403. 2006
    Usefulness of nasal continuous positive airway pressure (NCPAP) in severe acute bronchiolitis has been checked. The objective of this descriptive study was to evaluate the feasibility, safety and risk factors of NCPAP failure.
  67. ncbi Nasal lavage leukotrienes in infants with RSV bronchiolitis
    Liviana Da Dalt
    Department of Pediatrics, University of Padova, Padova, Italy
    Pediatr Allergy Immunol 18:100-4. 2007
    Respiratory syncytial virus (RSV) bronchiolitis is a very common infection in infants and, after the acute phase, a number of patients develop a reactive airway disease that lasts for years...
  68. ncbi Complications in infants hospitalized for bronchiolitis or respiratory syncytial virus pneumonia
    Douglas F Willson
    PICU and the Division of Pediatric Critical Care, University of Virginia Children s Medical Center, Charlottesville, Virginia, USA
    J Pediatr 143:S142-9. 2003
    To characterize complications among infants hospitalized for bronchiolitis or respiratory syncytial virus (RSV).
  69. ncbi Comparison of pulmonary abnormalities on high-resolution computed tomography in patients with early versus longstanding rheumatoid arthritis
    Shunsuke Mori
    Department of Rheumatology, Kumamoto Saishunsou National Hospital, Kumamoto, Japan
    J Rheumatol 35:1513-21. 2008
    ..To identify the predominant radiological abnormalities in the lungs of patients with early rheumatoid arthritis (RA) and in those with longstanding RA...
  70. ncbi Bronchiolitis in Abha, Southwest Saudi Arabia: viral etiology and predictors for hospital admission
    Mohammed A Al-Shehri
    Department of Pediatrics, King Khalid University, Kingdom of Saudi Arabia
    West Afr J Med 24:299-304. 2005
    b>Bronchiolitis is the most common lower respiratory tract infection in children less than 24 months of age and the most frequent cause of hospitalization in infants under 6 months of age.
  71. ncbi Sole pathogen in acute bronchiolitis: is there a role for other organisms apart from respiratory syncytial virus?
    Dan Miron
    Department of Pediatric A, Ha Emek Medical Center, Afula 18101, Israel
    Pediatr Infect Dis J 29:e7-e10. 2010
    Acute bronchiolitis (AB) is a common disease of young children with peak incidence during the winter season...
  72. ncbi Respiratory bronchiolitis-interstitial lung disease: long-term outcome
    Joshua Portnoy
    National Jewish Medical and Research Center, 1400 Jackson St, Denver, CO 80206, USA
    Chest 131:664-71. 2007
    The clinical and physiologic features of respiratory bronchiolitis (RB)-interstitial lung disease (ILD) have been previously described; however, the natural history and outcome have not been systematically evaluated...
  73. ncbi Decreasing unnecessary utilization in acute bronchiolitis care: results from the value in inpatient pediatrics network
    Shawn Ralston
    Department of Pediatrics, Division of Inpatient Pediatrics, University of Texas Health Science Center San Antonio, San Antonio, Texas, USA
    J Hosp Med 8:25-30. 2013
    Acute viral bronchiolitis is the most common diagnosis resulting in hospital admission in pediatrics...
  74. ncbi Airway IFN-γ production during RSV bronchiolitis is associated with eosinophilic inflammation
    Chang Keun Kim
    Department of Pediatrics, Asthma and Allergy Center, Inje University Sanggye Paik Hospital, Seoul, Korea
    Lung 190:183-8. 2012
    This study was designed to investigate the possible role of IFN-γ in eosinophil degranulation that occurs during respiratory syncytial virus (RSV) bronchiolitis.
  75. ncbi Heliox therapy in bronchiolitis: phase III multicenter double-blind randomized controlled trial
    Mina M Chowdhury
    Department of Pediatrics, Wright Fleming Institute, Imperial College, London, United Kingdom
    Pediatrics 131:661-9. 2013
    Supportive care remains the mainstay of therapy in bronchiolitis. Earlier studies suggest that helium-oxygen therapy may be beneficial, but evidence is limited...
  76. ncbi Racemic adrenaline and inhalation strategies in acute bronchiolitis
    Håvard Ove Skjerven
    Department of Pediatrics, Oslo University Hospital, Oslo, Norway
    N Engl J Med 368:2286-93. 2013
    Acute bronchiolitis in infants frequently results in hospitalization, but there is no established consensus on inhalation therapy--either the type of medication or the frequency of administration--that may be of value...
  77. ncbi Burden of infant bronchiolitis: data from a hospital network
    D Che
    Institut de Veille Sanitaire, Saint Maurice, France
    Epidemiol Infect 138:573-5. 2010
    In France, surveillance of bronchiolitis is based on a pilot network of hospital emergency departments. The study was a 1-year observational study (2007-2008) carried out in a central region of metropolitan France...
  78. ncbi The risk of bronchiolitis hospitalisation following administration of a group B meningococcal vaccine in New Zealand
    Paul Stehr-Green
    Department of Epidemiology, University of Washington, Seattle, Washington, USA
    N Z Med J 120:U2746. 2007
    ..participants (including five children who had been vaccinated with this vaccine) were hospitalised due to acute bronchiolitis. We examined more closely the potential association between bronchiolitis hospitalisation and this vaccine.
  79. ncbi Bronchiolitis-associated encephalopathy in critically-ill infants: an underestimated complication?
    Roberto Antonucci
    Department of Pediatrics and Clinical Medicine, University of Cagliari, Cagliari, Italy
    J Matern Fetal Neonatal Med 23:431-6. 2010
    To investigate the bronchiolitis-associated encephalopathy in critically ill infants.
  80. pmc Association of respiratory syncytial virus bronchiolitis with the interleukin 8 gene region in UK families
    J Hull
    University Department of Paediatrics, Level 4, John Radcliffe Hospital, Oxford OX3 9DU
    Thorax 55:1023-7. 2000
    ..Why some develop bronchiolitis is poorly understood; it is not known whether there is a genetic component...
  81. ncbi Epidemiology of hospitalization for acute bronchiolitis in children: differences between RSV and non-RSV bronchiolitis
    D Hervas
    Son Dureta University Hospital, Palma de Mallorca, The Balearic Islands, Spain
    Eur J Clin Microbiol Infect Dis 31:1975-81. 2012
    ..clinical, management and outcome differences between respiratory syncytial virus (RSV) positive and negative bronchiolitis. A retrospective review of the medical records of children ≤ 2 years of age with acute bronchiolitis between ..
  82. ncbi [Prospective regional study of an epidemic of respiratory syncytial virus (RSV) bronchiolitis]
    M Grimaldi
    Service de Pediatrie 2, Hôpital d Enfants, 10, Boulevard du Maréchal de Lattre de Tassigny, 21034 Dijon, France
    Arch Pediatr 9:572-80. 2002
    ..admission in pediatric intensive care units (PICU) among infants hospitalized for treatment of RSV induced bronchiolitis. This study was population-based and was conducted in Burgundy, a French region with 1,800,000 inhabitants ..
  83. ncbi Rhinovirus bronchiolitis and recurrent wheezing: 1-year follow-up
    F Midulla
    Dept of Paediatrics, Sapienza University Rome, Viale Regina Elena 324, 00161 Rome, Italy
    Eur Respir J 39:396-402. 2012
    The association between bronchiolitis and recurrent wheezing remains controversial...
  84. ncbi RSV-induced bronchiolitis but not upper respiratory tract infection is accompanied by an increased nasal IL-18 response
    Inesz J van Benten
    Department of Otorhinolaryngology, Erasmus Medical Centre Rotterdam, The Netherlands
    J Med Virol 71:290-7. 2003
    The aim of this study was to investigate potential differences in the local nasal immune response between bronchiolitis and upper respiratory tract infection induced by respiratory syncytial virus (RSV)...
  85. ncbi Prevalence of Bordetella pertussis and Bordetella parapertussis in infants presenting to the emergency department with bronchiolitis
    Paul F Walsh
    Department of Emergency Medicine, Kern Medical Center, Bakersfield, California 93305, USA
    J Emerg Med 40:256-61. 2011
    ..The clinical presentation of Bordetella pertussis can overlap with that of respiratory syncytial virus (RSV), and coinfection does occur, but management differs...
  86. pmc Short term effects of adrenaline in bronchiolitis: a randomised controlled trial
    A Abul-Ainine
    Children s Hospital, Leicester Royal Infirmary, University Hospitals of Leicester, Leicester, UK
    Arch Dis Child 86:276-9. 2002
    Airway narrowing in acute bronchiolitis does not respond to inhaled bronchodilators but does to adrenaline when compared to bronchodilators. Influences of supportive care were not considered in previous treatment studies.
  87. ncbi [Success and failure predictors of non-invasive ventilation in acute bronchiolitis]
    J Mayordomo-Colunga
    Seccion de Cuidados Intensivos Pediatricos, Hospital Universitario Central de Asturias, Oviedo, Espana
    An Pediatr (Barc) 70:34-9. 2009
    The objective was to identify predictive factors for non-invasive ventilation (NIV) failure and to describe its use in bronchiolitis.
  88. ncbi A randomized, controlled trial of nebulized terbutaline for the first acute bronchiolitis in infants less than 12-months-old
    Faten Tinsa
    Department of Pediatrics B of the Children s Hospital of Tunis, Boulevard 9 avril, 1007 Jabbary, Tunis, Tunisia
    Tunis Med 87:200-3. 2009
    Despite the common clinical practice, the available evidence on the efficacy of bronchodilators therapy for bronchiolitis is conflicting...
  89. ncbi Right ventricular function in children with severe respiratory syncytial virus (RSV) bronchiolitis
    K Thorburn
    Department of Pediatric Intensive Care, Royal Liverpool Children s Hospital Alder Hey, Liverpool, UK
    Minerva Anestesiol 77:46-53. 2011
    ..The aim of this study was to assess right ventricular function in children with severe RSV disease and to investigate an association with disease severity, myocardial damage, and hepatitis...
  90. ncbi Efficacy of nebulized epinephrine versus salbutamol in hospitalized infants with bronchiolitis
    P Bertrand
    Department of Pediatrics, School of Medicine, Catholic University of Chile, Santiago, Chile
    Pediatr Pulmonol 31:284-8. 2001
    We enrolled 30 infants (median age 3 months, range 1-12 months), hospitalized for bronchiolitis in a randomized double-blind trial, to examine the efficacy and safety of nebulized epinephrine compared to salbutamol...
  91. ncbi High risk for RSV bronchiolitis in late preterms and selected infants affected by rare disorders: a dilemma of specific prevention
    P Manzoni
    Neonatology and NICU, S Anna Hospital, ASO OI Regina Margherita S Anna, Torino, Italy
    Early Hum Dev 88:S34-41. 2012
    Respiratory syncytial virus (RSV) is the most frequent aetiologic agent that causes bronchiolitis and lower respiratory tract infection in infants...
  92. ncbi Incidence and predisposing factors for severe disease in previously healthy term infants experiencing their first episode of bronchiolitis
    Paola Papoff
    Pediatric Emergency and Intensive Care, Department of Pediatrics, Sapienza University of Rome, Rome, Italy
    Acta Paediatr 100:e17-23. 2011
    To determine the incidence and predisposing factors for severe bronchiolitis in previously healthy term infants <12 months of age experiencing their first episode of bronchiolitis.
  93. ncbi Efficacy of salbutamol and ipratropium bromide in the management of acute bronchiolitis--a clinical trial
    Bulent Karadag
    Division of Pediatric Pulmonology, Marmara University, Istanbul, Turkey
    Respiration 76:283-7. 2008
    A wide range of drugs are commonly used to treat bronchiolitis, but evidence of their effectiveness is limited.
  94. ncbi Transient hyperphosphatasemia in an infant with bronchiolitis and pneumonia
    Slavica Dodig
    Srebrnjak Children s Hospital, Srebrnjak 100, HR 10000 Zagreb, Croatia
    Eur J Med Res 13:536-8. 2008
    We present a case of benign transient hyperphosphatasemia in a 4-month-old infant with acute bronchiolitis and pneumonia...
  95. pmc Gene expression of nucleic acid-sensing pattern recognition receptors in children hospitalized for respiratory syncytial virus-associated acute bronchiolitis
    Carolina Scagnolari
    Department of Experimental Medicine, Virology Section, Sapienza University of Rome, Viale di Porta Tiburtina 28, 00185 Rome, Italy
    Clin Vaccine Immunol 16:816-23. 2009
    ..with respiratory syncytial virus (RSV) infection might explain the broad clinical spectrum of RSV-associated bronchiolitis in infants...
  96. ncbi Neurally triggered breaths reduce trigger delay and improve ventilator response times in ventilated infants with bronchiolitis
    Katherine C Clement
    Division of Pediatric Critical Care Medicine, Department of Anesthesiology, University of North Carolina at Chapel Hill, 214 MacNider, CB 7221, Chapel Hill, NC 27599 7221, USA
    Intensive Care Med 37:1826-32. 2011
    ..We hypothesized that neurally triggered breaths would reduce trigger delay, ventilator response times, and work of breathing in pediatric patients with bronchiolitis.
  97. ncbi Risk factors for recurrent wheezing following acute bronchiolitis: a 12-month follow-up
    Lorena Cifuentes
    Ambulatory Service, Department of Pediatrics, School of Medicine, Catholic University of Chile, Lira 85, Santiago de Chile, 833 0074 Chile
    Pediatr Pulmonol 36:316-21. 2003
    ..of this study was to identify wheezing recurrences and related risk factors in two groups of infants with bronchiolitis: respiratory syncytial virus (RSV)+ and RSV- as determined by RSV enzyme immunoassay...
  98. ncbi US outpatient office visits for bronchiolitis, 1993-2004
    Jonathan M Mansbach
    Department of Medicine, Children s Hospital Boston, MA 02115, USA
    Ambul Pediatr 7:304-7. 2007
    To describe the clinical epidemiology of US outpatient visits for children younger than 2 years with bronchiolitis.
  99. ncbi An artificial neural network ensemble to predict disposition and length of stay in children presenting with bronchiolitis
    Paul Walsh
    Department of Emergency Medicine, Kern Medical Center, Bakersfield, CA 93305, USA
    Eur J Emerg Med 11:259-64. 2004
    ..An ensemble is a 'committee' of neural networks that usually outperforms single neural networks. Bronchiolitis is a common manifestation of viral lower respiratory tract infection in infants and toddlers.
  100. ncbi Does respiratory syncytial virus subtype influences the severity of acute bronchiolitis in hospitalized infants?
    Nikolaos G Papadopoulos
    Research Laboratories, 2nd Department of Pediatrics, University of Athens School of Medicine, 13 Levadias Str, Goudi 11527, Greece
    Respir Med 98:879-82. 2004
    ..It is still not clear whether clinical severity of acute bronchiolitis differs between the two subtypes...
  101. ncbi [Current management of acute bronchiolitis in Tunisia]
    Khaled Menif
    Service de Reanimation, Pédiatrique Polyvalente Hôpital d Enfants de TunisPlace Bab Saadoun, Tunis
    Tunis Med 85:665-8. 2007
    The purpose of this study was to assess the current management practices of acute bronchiolitis by tunisian paediatricians.

Research Grants70

  1. RSV Upper Airway Infection and Otitis Media
    JOAN E contact DURBIN; Fiscal Year: 2010
    ..Syncytial Virus (RSV) is a major cause of lower respiratory tract infection in infants and the elderly, and bronchiolitis and pneumonia caused by RSV are the primary reason for hospitalization of young children...
  2. Biology and Pathologies of Type V Collagen
    Daniel S Greenspan; Fiscal Year: 2013
    ..2) We previously found autoimmunity to the 11(V) collagen chain to predispose patients to obliterative bronchiolitis(OB), the fibroproliferative process responsible for rejection of >50% of lung transplants...
  3. Immune Mechanism of Rejection in Human Lung Allografts
    Thalachallour Mohanakumar; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Chronic rejection, clinically diagnosed as Bronchiolitis obliterans Syndrome (BOS), is the most significant long term cause of morbidity and mortality following human lung transplantation (LTx)...
  4. Novel Means to Establish Free Radical Balance in the Neonatal Premature Lung
    Prakash Jagtap; Fiscal Year: 2011
    ..profound effects on quality of life and necessitating frequent and lifelong hospitalizations for pneumonia and bronchiolitis. Our current understanding of RDS and BPD is consistent with a mechanism of injury produced by an excess of O2-..
  5. Mechanisms and Enviromental Determinants of Rhinovirus Illness Severity
    James E Gern; Fiscal Year: 2013
    ..have demonstrated that rhinovirus (HRV) is an important cause of lower respiratory illness including bronchiolitis, influenza-like illness, and exacerbations of chronic lung diseases such as asthma, cystic fibrosis, and ..
  6. Role of TLR-4 in Lung Reperfusion Injury
    MICHAEL SCOTT MULLIGAN; Fiscal Year: 2013
    ..transplant recipients and leads to enhanced MHC class II expression, acute graft dysfunction, earlier onset of bronchiolitis obliterans and increased recipient mortality...
  7. Single RNA sensitive probes for studying viral replication and budding
    Philip J Santangelo; Fiscal Year: 2013
    ..RELEVANCE: Human respiratory syncytial virus (hRSV), an RNA virus, is the leading cause of viral pneumonia, bronchiolitis, respiratory failure, mechanical ventilation, and viral death in infants in the USA and worldwide, and causes ..
  8. The Role of Complement in Airway Microvascular Disease
    MARK ROBERT NICOLLS; Fiscal Year: 2013
    ..vasculature in lung allografts may be critical for preventing terminal airway fibrosis, also known as the bronchiolitis obliterans syndrome...
  9. A Mucosal RSV Vaccine
    Kejian Yang; Fiscal Year: 2013
    ..RSV infection is the leading cause of pulmonary disease of the lower respiratory tract (bronchiolitis, pneumonia and respiratory failure) in infants due to virus-induced airway damage and complex inflammatory ..
  10. Antiviral activity of leflunomide against respiratory syncytial virus
    WILLIAM WALDMAN; Fiscal Year: 2009
    ..aims of this investigation are to test the hypothesis that leflunomide reduces RSV viral load and associated bronchiolitis in vivo, and to elucidate its antiviral mechanisms at the moleclular level...
  11. Development of Nanotherapeutics for RSV-induced Lung Disease
    Shyam S Mohapatra; Fiscal Year: 2013
    ..RSV is an opportunistic human respiratory pathogen that causes bronchiolitis in infants and pneumonia in immunocompromised adults and the elderly with an estimated 64 million infections ..
  12. TH17 Autoimmunity to Type V Collagen in Heart and Lung Transplant
    David S Wilkes; Fiscal Year: 2013
    ..a component of normal extracellular matrix (ECM) and the process of chronic rejection, known as obliterative bronchiolitis in lung transplants recipients...
  13. Eicosanoid Balance in Lung Transplant Injury and Repair
    David Pinsky; Fiscal Year: 2009
    ..lung graft failure occurs in up to 20% of recipients, and by 5 years, over half of all patients develop bronchiolitis obliterans (BO), the major cause of death outside of infections...
  14. TSLP and Childhood Asthma
    Steven F Ziegler; Fiscal Year: 2012
    ..However, 1-2% of previously healthy full term infants require hospitalization for RSV bronchiolitis. Several studies have shown that these children are at increased risk for subsequent wheezing or asthma for up ..
  15. Role of Calcium-Activated Chloride Channels in Airway Disease Phenotypes
    ANAND CHAMPAK PATEL; Fiscal Year: 2011
    ..Studies will be performed in vivo using our mouse models of viral bronchiolitis and allergen challenge and in vitro using primary-culture mouse airway epithelial cells grown at air-liquid ..
  16. Absorption, distribution, metabolism, excretion (ADME) of chemicals in mammals
    Rochelle W Tyl; Fiscal Year: 2009
    ..of toxicity;2,3-butanedione;diacetyl;N,N-dimethylacetoacetamide;obliterative bronchiolitis;CYP;eugenol;safrole;estragole;anethole;myristicin;isosafrole;isoeugenol;methyleugenol;1,3-dichloro-2-propanol;..
  17. Role of epithelial HLA-G in lung transplantation
    Steven R White; Fiscal Year: 2010
    ..Chronic allograft rejection (bronchiolitis obliterans syndrome, or BOS) is the major limitation to long-term survival, yet its pathogenesis is poorly ..
  18. Role of IL-17 in the Induction of Epithelial to Mesenchymal Transition
    Ragini Vittal; Fiscal Year: 2013
    ..in fibrotic diseases, such as idiopathic pulmonary fibrosis (IPF) and lung transplant associated obliterative bronchiolitis (OB)...
  19. Whole Genome Association Analysis of Hematopoietic Cell Transplant (HCT) Outcome
    JOHN ANDREW HANSEN; Fiscal Year: 2013
    ..analyzed will include acute and chronic GVHD, immunological tolerance, airflow obstruction (AFO disease/bronchiolitis obliterans syndrome (BOS), acute kidney injury (AKI), Gram negative bacteremia, invasive fungal disease, CMV ..
  20. Novel Cellular Immune Profiles to Predict Lung Disease Outcomes
    Scott M Palmer; Fiscal Year: 2012
    ..Our application focuses on bronchiolitis obliterans syndrome (BOS), a fibrotic disease that occurs after human lung transplantation and is the primary ..
  21. Bronchoalveolar Lavage Cell Biomarkers in Lung Rejection
    Marshall I Hertz; Fiscal Year: 2010
    ..those of kidney, heart, and liver recipients, largely due to the effects of acute and chronic lung rejection (bronchiolitis obliterans syndrome, BOS)...
  22. Studies to Evaluate the Toxic Carcinogenic Potential of Test Agents
    JEFFERY DILL; Fiscal Year: 2009
    ..ABAs have been linked to occupational exposure and human health effects including bronchiolitis obliterans. Animal studies are neede to determine the potential for human health effects to individual ABAs...
  23. SP-D as an immunomodulatory protein in acute rejection in lung transplantation
    KAREN D SIMS; Fiscal Year: 2010
    ..rejection (ACR) affects 50% of recipients in the first year, and is a risk factor for the development of bronchiolitis obliterans syndrome, the leading cause of death in lung transplant recipients...
  24. Role of T Regulatory Cells in Preventing Human BOS
    Aric L Gregson; Fiscal Year: 2013
    ..Long-term survival is largely dependent upon recipients remaining free of bronchiolitis obliterans syndrome (BOS)...
  25. Genetic Analysis of Airflow Obstruction After Stem Cell Transplantation
    Joan G Clark; Fiscal Year: 2013
    ..Known as bronchiolitis obliterans syndrome in its severest form, this syndrome is now estimated to affect up to 26% of patients who ..
  26. ALLOANTIBODIES TO MHC INDUCES AUTOIMMUNITY AND OBLITERATIVE AIRWAY DISEASE (OAD)
    Thalachallour Mohanakumar; Fiscal Year: 2012
    ..However, long-term survival of the lung allograft is limited by the development of bronchiolitis obliterans syndrome (BOS), a condition unresponsive to therapy and often fatal...
  27. Studies to Evaluate the Toxic Carcinogenic Potential of Test Agents
    JEFFERY DILL; Fiscal Year: 2010
    ..ABAs have been linked to occupational exposure and human health effects including bronchiolitis obliterans. Animal studies are needed to determine the potential for human health effects to individual ABAs...
  28. Studies to Evaluate the Toxic Carcinogenic Potential of Test Agents
    JEFFERY DILL; Fiscal Year: 2011
    ..ABAs have been linked to occupational exposure and human health effects including bronchiolitis obliterans. Animal studies are needed to determine the potential for human health effects to individual ABAs...
  29. INNATE IMMUNE REGULATION OF PRIMARY GRAFT DYSFUNCTION
    Howard J Huang; Fiscal Year: 2013
    ..Importantly, PGD is also a risk factor for developing Bronchiolitis Obliterans Syndrome, the main cause of late graft failure and death in this population...
  30. TREATMENT OF ANTI-HLA ANTIBODIES TO PREVENT BOS AFTER LUNG TRANSPLANTATION
    Roger D Yusen; Fiscal Year: 2011
    DESCRIPTION (provided by applicant): Chronic rejection or bronchiolitis obliterans syndrome (BOS) has emerged as the primary obstacle to long- term survival after lung transplantation...
  31. Adenosine 2A Receptor Signaling in Lung Transplant Injury and Rejection
    Christine L Lau; Fiscal Year: 2013
    ..Importantly, IRI is a significant risk factor for the development of chronic allograft rejection, bronchiolitis obliterans (BO). Evidence supports alloimmune-dependent and alloimmune-independent factors in the etiology BO...
  32. Role of the Respiratory Syncytial Virus Fusion Protein in Airway Mucus Induction
    MARTIN LAWRENCE MOORE; Fiscal Year: 2013
    ..In contrast to laboratory RSV strains, RSV strains line 19 and 2-20 induce mucus and bronchiolitis in mice...
  33. The Role of TLR4 and RSV F Protein in Immunity to RSV
    JORGE C BLANCO; Fiscal Year: 2013
    ..Respiratory syncytial virus (RSV) is the leading cause of pneumonia and bronchiolitis in infants and young children worldwide, and has recently been attributed to increased morbidity and mortality ..
  34. Host Defense Mechanisms in Chronic Lung Disease
    Jo Rae Wright; Fiscal Year: 2010
    ..consists of four interrelated research projects that are focused on two chronic lung diseases: asthma and bronchiolitis obliterans syndrome (BOS) with a common underlying theme of epithelial injury, inflammation, repair and ..
  35. Research on inhalation toxicology of environmental chemicals
    ROBERT O apos CONNER; Fiscal Year: 2010
    ..Recent work includes studies of bronchiolitis obliterans caused by inhalation of artificial butter flavoring components, mechanisms of pleural fibrosis ..
  36. Research on inhalation toxicology of environmental chemicals
    ROBERT O'CONNER; Fiscal Year: 2011
    ..Recent work includes studies of bronchiolitis obliterans caused by inhalation of artificial butter flavoring components, mechanisms of pleural fibrosis ..
  37. Elafin Therapy for Lung Diseases
    Marlene Rabinovitch; Fiscal Year: 2013
    ..the microcirculation in the murine tracheal transplant model, and prevent airway ischemia associated with bronchiolitis obliterans...
  38. Molecular basis for paramyxovirus entry
    Anne Moscona; Fiscal Year: 2013
    ..by the human paramyxovirus parainfluenza virus (HPIV) causes major respiratory diseases, including croup, bronchiolitis and pneumonia, which lead to illness or death in millions of infants and young children worldwide...
  39. Development of CMV-specific T Cell Memory in Lung Transplant Recipients
    John F McDyer; Fiscal Year: 2012
    ..Active CMV infection is associated with acute and chronic rejection (bronchiolitis obliterans syndrome), with donor+/recipient- (D+R-) mismatched lung transplant recipients (LTRs) at highest ..
  40. Molecular basis for paramyxovirus entry
    Anne Moscona; Fiscal Year: 2012
    ..by the human paramyxovirus parainfluenza virus (HPIV) causes major respiratory diseases, including croup, bronchiolitis and pneumonia, which lead to illness or death in millions of infants and young children worldwide...
  41. Research on inhalation toxicology of environmental chemicals
    ROBERT O apos CONNER; Fiscal Year: 2009
    ..Recent work includes studies of bronchiolitis obliterans caused by inhalation of artificial butter flavoring components, mechanisms of pleural fibrosis ..
  42. Developing Quality Measures to Assess Pediatric Inpatient Respiratory Care
    Rita Mangione-Smith; Fiscal Year: 2013
    ..a detailed assessment of inpatient management for children treated for six respiratory conditions: asthma, bronchiolitis, croup, pneumonia, congenital lung malformations, and cystic fibrosis...
  43. Matrix Metalloproteinase-8 in Obliterative Bronchiolitis Post Lung Transplant
    Meera Subramaniam; Fiscal Year: 2010
    Obliterative bronchiolitis (OB) is a process of chronic rejection after lung transplantation and is a major challenge for long-term survival...
  44. Vitamin D deficiency and the severity of bronchiolitis
    Jonathan M Mansbach; Fiscal Year: 2012
    ..Camargo, MD, DrPH, conducting bronchiolitis research...
  45. Molecular and Cellular Interactions Between Cigarette Smoke Exposure and RSV
    Charles S Dela Cruz; Fiscal Year: 2013
    ..Respiratory syncytial virus (RSV) causes severe bronchiolitis in infants and worsens disease course in chronic obstructive lung disease (COPD) exacerbation in adults...
  46. Human Host Responses to Respiratory Syncytial Virus Infection
    NATALIE THORNBURG; Fiscal Year: 2010
    ..In the U.S., RSV can be detected in 43% of pediatric patients hospitalized with bronchiolitis and 25% with pneumonia...
  47. Prospective Cohort Study of Severe Bronchiolitis and Risk of Recurrent Wheezing
    Carlos A Camargo; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Bronchiolitis is the most common cause of infant hospitalization in the US...
  48. Immune Mediated Disorders After Allogeneic Hematopoietic Cell Transplants (HCT)
    Stephanie J Lee; Fiscal Year: 2013
    ..but poorly understood syndromes with particularly high morbidity/mortality: cutaneous sclerosis, bronchiolitis obliterans syndrome and late acute GVHD...
  49. Structural studies of respiratory syncytial virus
    Elizabeth R Wright; Fiscal Year: 2013
    ..To answer these questions, we are using the A2 strain of RSV that causes bronchiolitis, viral pneumonia, and death in young children, the elderly, and immuno-compromised individuals...
  50. Epidemiology and Etiology of Hospitalized Pneumonia in Children
    Krow Ampofo; Fiscal Year: 2013
    ..study to identify viral and bacterial pathogens which cause community-acquired pneumonia and complicated bronchiolitis in hospitalized children...
  51. Immune Mediated Disorders After Allogeneic Hematopoietic Cell Transplants (HCT)
    Stephanie J Lee; Fiscal Year: 2010
    ..but poorly understood syndromes with particularly high morbidity/mortality: cutaneous sclerosis, bronchiolitis obliterans syndrome and late acute GVHD...
  52. A Critical Role for the Microvasculature in Airway Transplantation
    MARK ROBERT NICOLLS; Fiscal Year: 2013
    ..microvasculature in lung allografts could be key for preventing terminal airway fibrosis, also known as the bronchiolitis obliterans syndrome (BOS)...
  53. NEUROGENIC INFLAMMATORY RESPONSE TO RSV
    Giovanni Piedimonte; Fiscal Year: 2013
    ..brain-derived neurotrophic factors (BDNF)] and trkA receptors in the lower airways of human infants with RSV bronchiolitis. We also found that the recruitment of lymphocytes and monocytes to infected airways is amplified by ..
  54. Indoleamine 2,3-dioxygenase protective role in lung transplantation
    Gary A Visner; Fiscal Year: 2010
    ..Acute and chronic rejection/bronchiolitis obliterans (BO) are major limiting factors for long-term lung allograft survival with chronic rejection coming ..
  55. Prospective Multicenter Study of Bronchiolitis Admissions: Etiology & Disposition
    Carlos A Camargo; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Specific Aims: Bronchiolitis is the leading cause of hospitalization for infants, but there is a lack of consensus about optimal management...
  56. Why Are Steroids Ineffective at Suppressing RSV Bronchiolitis
    Raymond J Pickles; Fiscal Year: 2013
    ..These histologic findings are remarkably similar to those found in airways of human infants with RSV bronchiolitis and suggest PIV- mediated RSV NS2 expression in hamster bronchioles represent a novel animal model for ..
  57. Epithelial Cell Bactercidal/Permeability Increasing Protein in Lung Injury
    Joan G Clark; Fiscal Year: 2010
    ..infection and LPS expression are common in chronic airway disease such as asthma, cystic fibrosis, and chronic bronchiolitis. Delineation of BPI as a molecular modifier of airway infections and inflammation could form the basis for ..
  58. Syndecan-1 in Lung Repair
    Peter Chen; Fiscal Year: 2013
    ..g., asthma remodeling, COPD, obliterative bronchiolitis, bronchiectasis)...
  59. Balance of Type 1 and 17 T cell Responses in Airway Rejection: The Role of T-bet
    ELIZABETH ANN LENDERMON; Fiscal Year: 2011
    ..However, obliterative bronchiolitis (OB), or chronic airway rejection, limits its long-term success and occurs despite calcineurin-inhibitor based ..
  60. IL-17 and Lung Transplant Obliterative Bronchiolitis
    Rebecca A Shilling; Fiscal Year: 2013
    ..50% for lung transplant patients is much lower compared to other solid organs due to the late complication of bronchiolitis obliterans syndrome for which there is no effective treatment...
  61. Mentored Patient Oriented Research in Lung Transplantation
    Jason D Christie; Fiscal Year: 2013
    ..response pre- operatively, and that these molecular mechanisms of lung injury in PGD are linked to subsequent bronchiolitis obliterans syndrome (BOS) risk...
  62. Midcareer Investigator Patient-oriented Research Award in Bronchiolitis &Asthma
    Tina V Hartert; Fiscal Year: 2013
    ..caused by viruses such as respiratory syncytial virus (RSV) and rhinovirus (RV), are a leading cause of bronchiolitis in infants...
  63. Spatially Accurate Deformable Image Registration for Thoracic C Applications
    Thomas M Guerrero; Fiscal Year: 2013
    ..They are unable to find air-trapping due to bronchiolitis alone...
  64. Nasal dosimetry of diacetyl and butyric acid vapors
    John Morris; Fiscal Year: 2005
    ..generally recognized as safe as food additives, exposure of workers to these vapors is associated with bronchiolitis obliterans...
  65. UVA Asthma and Allergic Diseases Center
    Thomas Platts Mills; Fiscal Year: 2005
    ..studies on the role of viral infections in asthma by studying infants and children hospitalized for asthma/bronchiolitis and by defining the role of pre-existing inflammation and IgE antibody (Ab) in the response to rhinoviral ..
  66. Innovative Methods for Immune Tolerance in Lung Transpl*
    David Wilkes; Fiscal Year: 2003
    ..The leading cause of death in lung allograft recipients is chronic rejection known as bronchiolitis obliterans (BO), and repeated acute rejection episodes are believed to culminate in BO...
  67. ASTHMA AND ALLERGIC DISEASES CENTER
    Thomas Platts Mills; Fiscal Year: 2000
    ..RSV in infancy is the most common cause of bronchiolitis. The G and F proteins will be used to investigate T cell responses in children who have been infected with RSV...
  68. RESPIRATORY SYNCYTIAL VIRUS BRONCHIOLITIS IN SHEEP
    Arlene Stecenko; Fiscal Year: 1991
    Respiratory syncytial virus (RSV) is the most common cause of pneumonia and bronchiolitis in infancy. After an episode of RSV bronchiolitis severe enough to require hospitalization, 20-40% of infants develop asthma...
  69. IMMUNE REGULATION IN LUNG TRANSPLANTATION
    WILLIAM BURLINGHAM; Fiscal Year: 2003
    ..trial including patients from the UW-Madison is underway to see if a form of rapamycin (RAD) can prevent bronchiolitis obliterans syndrome (BOS) while improving long-term outcome in lung transplants...
  70. CHEMOKINE BIOLOGY IN BRONCHIOLITIS OBLITERANS SYNDROME
    John Belperio; Fiscal Year: 2005
    Adapted from applicant's abstract) Chronic lung allograft rejection, Bronchiolitis Obliterans Syndrome (BOS) is a chronic process that demonstrates features of dysregulated and aberrant repair of airways...