respiratory tract infections

Summary

Top Publications

  1. ncbi Respiratory syncytial virus infection in elderly and high-risk adults
    Ann R Falsey
    Department of Medicine, Rochester General Hospital, Rochester, NY 14621, USA
    N Engl J Med 352:1749-59. 2005
  2. ncbi Infections and airway inflammation in chronic obstructive pulmonary disease severe exacerbations
    Alberto Papi
    Research Center on Asthma and COPD, Department of Respiratory Diseases, University of Modena and Reggio Emilia, Via del Pozzo 71, I 41100 Modena, Italy
    Am J Respir Crit Care Med 173:1114-21. 2006
  3. ncbi A newly discovered human pneumovirus isolated from young children with respiratory tract disease
    B G van den Hoogen
    Department of Virology, Erasmus Medical Center, Rotterdam, The Netherlands
    Nat Med 7:719-24. 2001
  4. ncbi Estimates of world-wide distribution of child deaths from acute respiratory infections
    Brian G Williams
    World Health Organization, 20 Avenue Appia, Geneva 27, CH 1211, Switzerland
    Lancet Infect Dis 2:25-32. 2002
  5. ncbi Respiratory viruses, symptoms, and inflammatory markers in acute exacerbations and stable chronic obstructive pulmonary disease
    T Seemungal
    Academic Department of Respiratory Medicine and Virology, St. Bartholomew's and Royal London School of Medicine and Dentistry, London, UK
    Am J Respir Crit Care Med 164:1618-23. 2001
  6. pmc Respiratory viral infections in infants: causes, clinical symptoms, virology, and immunology
    John S Tregoning
    Centre for Infection, Department of Cellular and Molecular Medicine, St George s University of London, London, United Kingdom
    Clin Microbiol Rev 23:74-98. 2010
  7. pmc Role of viral respiratory infections in asthma and asthma exacerbations
    William W Busse
    Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA
    Lancet 376:826-34. 2010
  8. ncbi Effectiveness of maternal influenza immunization in mothers and infants
    K Zaman
    International Centre for Diarrheal Disease Research, Dhaka, Bangladesh
    N Engl J Med 359:1555-64. 2008
  9. ncbi The effect of influenza on hospitalizations, outpatient visits, and courses of antibiotics in children
    K M Neuzil
    Department of Medicine, University of Washington School of Medicine, Seattle, USA
    N Engl J Med 342:225-31. 2000
  10. ncbi Effect of antibiotic prescribing in primary care on antimicrobial resistance in individual patients: systematic review and meta-analysis
    Ceire Costelloe
    Academic Unit of Primary Health Care, NIHR National School for Primary Care Research, Department of Community Based Medicine, University of Bristol, Bristol BS8 2AA
    BMJ 340:c2096. 2010

Detail Information

Publications362 found, 100 shown here

  1. ncbi Respiratory syncytial virus infection in elderly and high-risk adults
    Ann R Falsey
    Department of Medicine, Rochester General Hospital, Rochester, NY 14621, USA
    N Engl J Med 352:1749-59. 2005
    ..Data on the epidemiology and clinical effects in community-dwelling elderly persons and high-risk adults can help in assessing the need for vaccine development...
  2. ncbi Infections and airway inflammation in chronic obstructive pulmonary disease severe exacerbations
    Alberto Papi
    Research Center on Asthma and COPD, Department of Respiratory Diseases, University of Modena and Reggio Emilia, Via del Pozzo 71, I 41100 Modena, Italy
    Am J Respir Crit Care Med 173:1114-21. 2006
    ..Severe exacerbations of chronic obstructive pulmonary disease (COPD) are major causes of health care costs mostly related to hospitalization. The role of infections in COPD exacerbations is controversial...
  3. ncbi A newly discovered human pneumovirus isolated from young children with respiratory tract disease
    B G van den Hoogen
    Department of Virology, Erasmus Medical Center, Rotterdam, The Netherlands
    Nat Med 7:719-24. 2001
    ..Serological studies showed that by the age of five years, virtually all children in the Netherlands have been exposed to human metapneumovirus and that the virus has been circulating in humans for at least 50 years...
  4. ncbi Estimates of world-wide distribution of child deaths from acute respiratory infections
    Brian G Williams
    World Health Organization, 20 Avenue Appia, Geneva 27, CH 1211, Switzerland
    Lancet Infect Dis 2:25-32. 2002
    ..This analysis suggests that throughout the world 1.9 million (95% CI 1.6-2.2 million) children died from ARI in 2000, 70% of them in Africa and southeast Asia...
  5. ncbi Respiratory viruses, symptoms, and inflammatory markers in acute exacerbations and stable chronic obstructive pulmonary disease
    T Seemungal
    Academic Department of Respiratory Medicine and Virology, St. Bartholomew's and Royal London School of Medicine and Dentistry, London, UK
    Am J Respir Crit Care Med 164:1618-23. 2001
    ..Prevention and early treatment of viral infections may lead to a decreased exacerbation frequency and morbidity associated with COPD...
  6. pmc Respiratory viral infections in infants: causes, clinical symptoms, virology, and immunology
    John S Tregoning
    Centre for Infection, Department of Cellular and Molecular Medicine, St George s University of London, London, United Kingdom
    Clin Microbiol Rev 23:74-98. 2010
    ..Finally, both the virus and the immune response contribute to damage to the lungs and subsequent disease, and therefore, any prevention or treatment needs to address both of these factors...
  7. pmc Role of viral respiratory infections in asthma and asthma exacerbations
    William W Busse
    Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA
    Lancet 376:826-34. 2010
    Viral respiratory tract infections are common and usually selflimited illnesses...
  8. ncbi Effectiveness of maternal influenza immunization in mothers and infants
    K Zaman
    International Centre for Diarrheal Disease Research, Dhaka, Bangladesh
    N Engl J Med 359:1555-64. 2008
    ..We assessed the clinical effectiveness of inactivated influenza vaccine administered during pregnancy in Bangladesh...
  9. ncbi The effect of influenza on hospitalizations, outpatient visits, and courses of antibiotics in children
    K M Neuzil
    Department of Medicine, University of Washington School of Medicine, Seattle, USA
    N Engl J Med 342:225-31. 2000
    ..We measured the disease burden of influenza in a large cohort of healthy children in the Tennessee Medicaid program who were younger than 15 years of age...
  10. ncbi Effect of antibiotic prescribing in primary care on antimicrobial resistance in individual patients: systematic review and meta-analysis
    Ceire Costelloe
    Academic Unit of Primary Health Care, NIHR National School for Primary Care Research, Department of Community Based Medicine, University of Bristol, Bristol BS8 2AA
    BMJ 340:c2096. 2010
    ..To systematically review the literature and, where appropriate, meta-analyse studies investigating subsequent antibiotic resistance in individuals prescribed antibiotics in primary care...
  11. pmc Nontuberculous mycobacteria in respiratory tract infections, eastern Asia
    Sami Simons
    Department of Pulmonary Diseases, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Emerg Infect Dis 17:343-9. 2011
    ..This geographic variation is not well reflected in the American Thoracic Society criteria for NTM infections and could be incorporated in future guidelines...
  12. ncbi Effect of procalcitonin-based guidelines vs standard guidelines on antibiotic use in lower respiratory tract infections: the ProHOSP randomized controlled trial
    Philipp Schuetz
    Department of Internal Medicine, Kantonsspital Aarau, Tellstrasse, CH 5001 Aarau, Switzerland
    JAMA 302:1059-66. 2009
    In previous smaller trials, a procalcitonin (PCT) algorithm reduced antibiotic use in patients with lower respiratory tract infections (LRTIs).
  13. ncbi Guidelines for the management of adult lower respiratory tract infections--full version
    M Woodhead
    Department of Respiratory Medicine, Manchester Royal Infirmary, Oxford Road, Manchester, UK
    Clin Microbiol Infect 17:E1-59. 2011
    ..Background sections and graded evidence tables are also included. The target audience for the Guideline is thus all those whose routine practice includes the management of adult LRTI...
  14. pmc Respiratory viral infections among pediatric inpatients and outpatients in Taiwan from 1997 to 1999
    H P Tsai
    National Health Research Institutes Tainan Virology Laboratory for Diagnosis and Research, Department of Pathology, National Cheng Kung University Hospital, Tainan, Taiwan
    J Clin Microbiol 39:111-8. 2001
    ..These data expand our understanding of the etiology of acute respiratory tract viral infections among in- and outpatients in a subtropical country and may contribute to the prevention and control of viral respiratory tract infections.
  15. ncbi Viral respiratory infections in hospitalized and community control children in Alaska
    Rosalyn J Singleton
    Alaska Native Tribal Health Consortium, Anchorage, Alaska
    J Med Virol 82:1282-90. 2010
    ..Rhinovirus and adenovirus were detected in two-thirds of hospitalized children, but their frequent detection in control children made their role in respiratory hospitalization uncertain...
  16. ncbi Procalcitonin to initiate or discontinue antibiotics in acute respiratory tract infections
    Philipp Schuetz
    Department of Emergency Medicine, Harvard School of Public Health, Boston, MA, USA
    Cochrane Database Syst Rev 9:CD007498. 2012
    ....
  17. ncbi Are meteorological parameters associated with acute respiratory tract infections?
    Jean Baptist du Prel
    Kinderklinik, Paediatrische Infektiologie and Zentrum Praeventive Paediatrie, Universitaetsmedizin, Johannes Gutenberg Universitaet, Mainz, Germany
    Clin Infect Dis 49:861-8. 2009
    Information on the onset of epidemics of acute respiratory tract infections (ARIs) is useful in timing preventive strategies (eg, the passive immunization of high-risk infants against respiratory syncytial virus [RSV])...
  18. ncbi Guidelines for the management of adult lower respiratory tract infections--summary
    M Woodhead
    Department of Respiratory Medicine, Manchester Royal Infirmary, Oxford Road, Manchester, UK
    Clin Microbiol Infect 17:1-24. 2011
    ..The target audience for the Guideline is thus all those whose routine practice includes the management of adult LRTI...
  19. ncbi Amoxicillin for acute lower-respiratory-tract infection in primary care when pneumonia is not suspected: a 12-country, randomised, placebo-controlled trial
    Paul Little
    Primary Care and Population Sciences Division, University of Southampton, Southampton, UK
    Lancet Infect Dis 13:123-9. 2013
    ..We aimed to compare the benefits and harms of amoxicillin for acute lower-respiratory-tract infection with those of placebo both overall and in patients aged 60 years or older...
  20. ncbi Molecular epidemiology of KI and WU polyomaviruses in infants with acute respiratory disease and in adult hematopoietic stem cell transplant recipients
    Maurizia Debiaggi
    Department of Morphological and Clinical Sciences, Section of Microbiology, University of Pavia, Pavia, Italy
    J Med Virol 82:153-6. 2010
    ..The results suggest that WU/KIPyVs have a limited circulation in Italy and a low pathogenic potential in young children. Brief and asymptomatic infection can occur in hematopoietic transplant recipients...
  21. ncbi Prevalence of human coronaviruses in adults with acute respiratory tract infections in Beijing, China
    Lili Ren
    State Key Laboratory for Molecular Virology and Genetic Engineering and Dr Christophe Mérieux Laboratory, IPB, CAMS Fondation Mérieux, Institute of Pathogen Biology IPB, Chinese Academy of Medical Sciences CAMS and Peking Union Medical College, Beijing, China
    J Med Virol 83:291-7. 2011
    Human coronaviruses (HCoVs) are a common etiological agent of acute respiratory tract infections. HCoV infections, especially those caused by the two HCoVs identified most recently, NL63 and HKU-1, have not been characterized fully...
  22. pmc Human Metapneumovirus: lessons learned over the first decade
    Verena Schildgen
    Dipl Biologe, Kliniken der Stadt Köln gGmbH, Krankenhaus Merheim, Klinikum der Privaten Universität Witten Herdecke, Institut fur Pathologie, Cologne, Germany
    Clin Microbiol Rev 24:734-54. 2011
    ..This review summarizes our current knowledge on HMPV, HMPV disease pathogenesis, and disease intervention strategies and identifies a number of areas with key questions to be addressed in the future...
  23. pmc Antibiotic prescribing for acute cough: the effect of perceived patient demand
    Samuel Coenen
    Fund for Scientific Research, Flanders, Belgium
    Br J Gen Pract 56:183-90. 2006
    ..GPs decide whether or not to prescribe antibiotics for acute cough. Apart from clinical signs and symptoms, non-medical reasons influence this decision as well...
  24. pmc Acute lower respiratory tract infection
    Joseph P Mizgerd
    Molecular and Integrative Physiological Sciences Program, Harvard School of Public Health, Boston, MA 02115, USA
    N Engl J Med 358:716-27. 2008
  25. pmc Social contacts and mixing patterns relevant to the spread of infectious diseases
    Joel Mossong
    Microbiology Unit, Laboratoire National de Santé, Luxembourg, Luxembourg
    PLoS Med 5:e74. 2008
    ..We conducted a population-based prospective survey of mixing patterns in eight European countries using a common paper-diary methodology...
  26. pmc The burden of hospitalized lower respiratory tract infection due to respiratory syncytial virus in rural Thailand
    Alicia M Fry
    Influenza Division, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America
    PLoS ONE 5:e15098. 2010
    ..We describe the epidemiology of hospitalized RSV infections for all age groups from population-based surveillance in two rural provinces in Thailand...
  27. pmc Enhancement of CURB65 score with proadrenomedullin (CURB65-A) for outcome prediction in lower respiratory tract infections: derivation of a clinical algorithm
    Werner C Albrich
    Medical University Department of the University of Basel, Kantonsspital Aarau, Switzerland
    BMC Infect Dis 11:112. 2011
    ..ProADM) confers additional prognostic information to established clinical risk scores in lower respiratory tract infections (LRTI)...
  28. pmc Interventions to influence consulting and antibiotic use for acute respiratory tract infections in children: a systematic review and meta-analysis
    Talley Andrews
    Department of Family Medicine, Oregon Health and Science University, Portland, Oregon, United States of America
    PLoS ONE 7:e30334. 2012
    b>Respiratory tract infections (RTIs) are common in children and generally self-limiting, yet often result in consultations to primary care...
  29. pmc Enterovirus genotype EV-104 in humans, Italy, 2008-2009
    Antonio Piralla
    Fondazione Istituto Di Ricovero e Cura a Carattere Scientifico Policlinico, San Matteo, Pavia, Italy
    Emerg Infect Dis 16:1018-21. 2010
    ..EV-104 is closely related to human rhinoviruses; thus, both types of viruses should be sought in respiratory syndromes...
  30. ncbi Early-life respiratory viral infections, atopic sensitization, and risk of subsequent development of persistent asthma
    Merci M H Kusel
    Telethon Institute for Child Health Research, Centre for Child Health Research, University of Western Australia, West Perth, Australia
    J Allergy Clin Immunol 119:1105-10. 2007
    ..Severe lower respiratory infections (LRIs) and atopic sensitization have been identified as independent risk factors for asthma...
  31. ncbi Correlation between bocavirus infection and humoral response, and co-infection with other respiratory viruses in children with acute respiratory infection
    Kai Wang
    Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai, People s Republic of China
    J Clin Virol 47:148-55. 2010
    ..Co-infection was frequently found in HBoV-positive patients. Thus, whether HBoV is responsible for the respiratory disease is still arguable...
  32. ncbi Childhood asthma after bacterial colonization of the airway in neonates
    Hans Bisgaard
    Danish Pediatric Asthma Center, Copenhagen University Hospital, Gentofte, Copenhagen
    N Engl J Med 357:1487-95. 2007
    ..We conducted a study to investigate a possible association between bacterial colonization of the hypopharynx in asymptomatic neonates and later development of recurrent wheeze, asthma, and allergy during the first 5 years of life...
  33. pmc Genetic adaptation of Pseudomonas aeruginosa to the airways of cystic fibrosis patients is catalyzed by hypermutation
    A Mena
    Servicio de Microbiologia, Hospital Son Dureta, Instituto Universitario de Investigación en Ciencias de la Salud IUNICS, Palma de Mallorca, Spain
    J Bacteriol 190:7910-7. 2008
    ..aeruginosa genome evolution and adaptation during CRI...
  34. ncbi Effects of in utero arsenic exposure on child immunity and morbidity in rural Bangladesh
    Rubhana Raqib
    International Centre for Diarrhoeal Disease Research, Bangladesh ICDDR, B, Dhaka, Bangladesh
    Toxicol Lett 185:197-202. 2009
    ..The effect seemed to be partially gender dependent. Arsenic exposure also affected breast milk content of trophic factors and maternal morbidity...
  35. ncbi Severe human lower respiratory tract illness caused by respiratory syncytial virus and influenza virus is characterized by the absence of pulmonary cytotoxic lymphocyte responses
    Timothy P Welliver
    MedImmune, Inc, Gaithersburg, MD, USA
    J Infect Dis 195:1126-36. 2007
    ..It is widely believed that both viral replication and inappropriately enhanced immune responses contribute to disease severity. In infants, RSV LRTI is known to be more severe than influenza virus LRTI...
  36. pmc Computational analysis identifies human adenovirus type 55 as a re-emergent acute respiratory disease pathogen
    Michael P Walsh
    Department of Bioinformatics and Computational Biology, George Mason University, 10900 University Blvd, MSN 5B3, Manassas, Virginia 20110, USA
    J Clin Microbiol 48:991-3. 2010
    ..4% HAdV-B14. Sporadic appearances as a re-emergent pathogen and misidentification as "HAdV-B11a" are due to this partial hexon...
  37. ncbi The role of viruses in acute exacerbations of asthma
    David J Jackson
    Department of Respiratory Medicine, National Heart and Lung Institute, Imperial College London, London, United Kingdom
    J Allergy Clin Immunol 125:1178-87; quiz 1188-9. 2010
    ....
  38. pmc Human enterovirus 109: a novel interspecies recombinant enterovirus isolated from a case of acute pediatric respiratory illness in Nicaragua
    Nathan L Yozwiak
    Division of Infectious Diseases and Vaccinology, School of Public Health, University of California, Berkeley, California, USA
    J Virol 84:9047-58. 2010
    ..Further experimentation is required to more fully characterize the pathogenic role, disease associations, and global distribution of EV109...
  39. ncbi Interactions between influenza and bacterial respiratory pathogens: implications for pandemic preparedness
    John F Brundage
    Army Medical Surveillance Activity, Washington, DC 20307 5001, USA
    Lancet Infect Dis 6:303-12. 2006
    ....
  40. ncbi Granulocyte inflammatory markers and airway infection during acute exacerbation of chronic obstructive pulmonary disease
    S D Aaron
    Department of Medicine, Ottawa Hospital Research Institute, University of Ottawa, Ottawa, Ontario, Canada
    Am J Respir Crit Care Med 163:349-55. 2001
    ..Three of 14 patients (21%) had confirmed bacterial or viral respiratory tract infections. Patients with documented infection did not demonstrate greater increases in sputum levels of ..
  41. pmc Frequent and prolonged shedding of bocavirus in young children attending daycare
    Emily T Martin
    Center for Clinical and Translational Research, Seattle Children s Research Institute, 1900 Ninth Avenue, Seattle, WA 98101, USA
    J Infect Dis 201:1625-32. 2010
    ..Little is known about human bocavirus (HBoV) persistence and shedding and the association between HBoV detection and the onset and resolution of respiratory symptoms...
  42. pmc New respiratory enterovirus and recombinant rhinoviruses among circulating picornaviruses
    Caroline Tapparel
    University of Geneva Hospitals, Switzerland
    Emerg Infect Dis 15:719-26. 2009
    ..This study clarifies the diversity and explains the reasons for evolution of these viruses...
  43. ncbi Proposed changes to management of lower respiratory tract infections in response to the Clostridium difficile epidemic
    James D Chalmers
    MRC Centre for Inflammation Research, Queens Medical Research Institute, 47 Little France Crescent, Edinburgh EH16 4TJ, UK
    J Antimicrob Chemother 65:608-18. 2010
    ..Lower respiratory tract infections (LRTIs) are the leading indication for antibiotic prescription in hospitals and are therefore a ..
  44. ncbi Using data on social contacts to estimate age-specific transmission parameters for respiratory-spread infectious agents
    Jacco Wallinga
    National Institute for Public Health and the Environment, Bilthoven, The Netherlands
    Am J Epidemiol 164:936-44. 2006
    ..These findings have important implications for controlling future outbreaks of novel respiratory-spread infectious agents...
  45. ncbi Human milk probiotic Lactobacillus fermentum CECT5716 reduces the incidence of gastrointestinal and upper respiratory tract infections in infants
    Jose Maldonado
    Hospital Universitario Virgen de las Nieves, Granada, Spain
    J Pediatr Gastroenterol Nutr 54:55-61. 2012
    ..The aim of the study was to examine the effects of a follow-on formula containing Lactobacillus fermentum CECT5716 (L. fermentum) on the incidence of infections in infants between the ages of 6 and 12 months...
  46. ncbi The economic burden of non-influenza-related viral respiratory tract infection in the United States
    A Mark Fendrick
    Division of General Internal Medicine, Department of Internal Medicine, School of Medicine, University of Michigan, 300 N Ingalls Bldg, Room 7E06, Ann Arbor, MI 48109 0376, USA
    Arch Intern Med 163:487-94. 2003
    ..Our objectives were to obtain an updated incidence of non-influenza-related VRTI in the United States and to quantify the health care resource use (direct costs) and productivity losses (indirect costs) associated with these infections...
  47. ncbi Antibiotic prescribing for acute respiratory tract infections in primary care: a systematic review and meta-ethnography
    Sarah Tonkin-Crine
    Primary Medical Care, University of Southampton, Aldermoor Health Centre, Aldermoor Close, Southampton SO16 5ST, UK
    J Antimicrob Chemother 66:2215-23. 2011
    Numerous interventions have been developed to promote prudent antibiotic use for acute respiratory tract infections (ARTIs)...
  48. ncbi Effect of vitamin D3 supplementation on upper respiratory tract infections in healthy adults: the VIDARIS randomized controlled trial
    David R Murdoch
    Department of Pathology, University of Otago, Christchurch, PO Box 4345, Christchurch 8011, New Zealand
    JAMA 308:1333-9. 2012
    ..have reported an inverse association between serum 25-hydroxyvitamin D (25-OHD) levels and incidence of upper respiratory tract infections (URTIs). However, results of clinical trials of vitamin D supplementation have been inconclusive.
  49. pmc Viral-bacterial interactions and risk of acute otitis media complicating upper respiratory tract infection
    Melinda M Pettigrew
    Yale School of Public Health, Yale School of Medicine, New Haven, CT 06520 8034, USA
    J Clin Microbiol 49:3750-5. 2011
    ..Acute otitis media prevention efforts should consider methods for reducing infections caused by respiratory syncytial virus, bocavirus, and adenovirus in addition to acute otitis media bacterial pathogens...
  50. ncbi Contribution of common and recently described respiratory viruses to annual hospitalizations in children in South Africa
    Marietjie Venter
    Department of Medical Virology, University of Pretoria, South Africa
    J Med Virol 83:1458-68. 2011
    ..RSV, hPMV, PIV-3, and influenza viruses had defined seasons while rhinovirus, adenovirus, and coronavirus infections occurred year round in this temporal region of sub-Saharan Africa...
  51. ncbi Nucleic acid amplification-based diagnosis of respiratory virus infections
    James B Mahony
    Regional Virology Laboratory, St Joseph s Healthcare Hamilton, 50 Charlton Ave East, Hamilton, ON, L8N 4A6, Canada
    Expert Rev Anti Infect Ther 8:1273-92. 2010
    ..These resistance assays together with new viral load tests will enable clinical laboratories to provide physicians with important information for optimal treatment of patients...
  52. pmc Epidemiology of human metapneumovirus
    Jeffrey S Kahn
    Department of Pediatrics, Division of Infectious Diseases, Yale University School of Medicine, P O Box 208064, New Haven, CT 06520 8064, USA
    Clin Microbiol Rev 19:546-57. 2006
    ..The virus is associated with both upper and lower respiratory tract infections and may be a trigger for asthma...
  53. pmc The effects of malnutrition on child mortality in developing countries
    D L Pelletier
    Division of Nutritional Sciences, Cornell University, Ithaca, New York 14853, USA
    Bull World Health Organ 73:443-8. 1995
    ..The methodology provided in this paper makes it possible to estimate the effects of malnutrition on child mortality in any population for which prevalence data exist...
  54. pmc Frequent detection of respiratory viruses without symptoms: toward defining clinically relevant cutoff values
    Rogier R Jansen
    Department of Medical Microbiology1 and Department of Pediatrics, 2 Academical Medical Centre, University of Amsterdam, Amsterdam, Netherlands
    J Clin Microbiol 49:2631-6. 2011
    ..This suggests that defining cutoff levels should be feasible and represents the next necessary step for diagnosing viral respiratory infections using molecular tests...
  55. ncbi Antibiotic prescription rates for acute respiratory tract infections in US ambulatory settings
    Carlos G Grijalva
    Department of Preventive Medicine, Vanderbilt University School of Medicine, 1500 21st Ave, Ste 2600, The Village at Vanderbilt, Nashville, TN 37232 2637, USA
    JAMA 302:758-66. 2009
    ..During the 1990s, antibiotic prescriptions for acute respiratory tract infection (ARTI) decreased in the United States. The sustainability of those changes is unknown...
  56. pmc WU and KI polyomavirus infections in pediatric hematology/oncology patients with acute respiratory tract illness
    Suchitra Rao
    Department of Pediatrics, B158 The Children s Hospital and University of Colorado School of Medicine, Aurora, CO 80045, USA
    J Clin Virol 52:28-32. 2011
    ..Other polyomaviruses (BKPyV and JCPyV) have been associated with illness in immunocompromised patients, and some studies suggest a higher prevalence of WUPyV and KIPyV in this population...
  57. pmc Viral infections of the lower respiratory tract: old viruses, new viruses, and the role of diagnosis
    Andrew T Pavia
    Department of Pediatrics, Division of Pediatric Infectious Diseases, University of Utah, Salt Lake City, UT 84108, USA
    Clin Infect Dis 52:S284-9. 2011
    ..cause an enormous disease burden in children, and the role of respiratory viruses in serious lower respiratory tract infections (LRTIs) in older adults is increasingly appreciated...
  58. ncbi Pseudomonas aeruginosa and other predictors of mortality and morbidity in young children with cystic fibrosis
    Julia Emerson
    Division of Pulmonary Medicine, Department of Pediatrics, University of Washington, Seattle, USA
    Pediatr Pulmonol 34:91-100. 2002
    ..These findings confirm reports from previous smaller studies of outcomes among young children with CF, and highlight the potential to decrease the morbidity and mortality of young patients with CF through early intervention...
  59. pmc Effect of using an interactive booklet about childhood respiratory tract infections in primary care consultations on reconsulting and antibiotic prescribing: a cluster randomised controlled trial
    Nick A Francis
    Department of Primary Care and Public Health, School of Medicine, Cardiff University, Neuadd Meirionnydd, Heath Park, Cardiff CF14 4XN
    BMJ 339:b2885. 2009
    To establish whether an interactive booklet on respiratory tract infections in children reduces reconsultation for the same illness episode, reduces antibiotic use, and affects future consulting intentions, while maintaining parental ..
  60. pmc Identification of respiratory viruses in adults: nasopharyngeal versus oropharyngeal sampling
    David Lieberman
    Pulmonary Unit, Soroka Medical Center, Beer Sheva 84101, Israel
    J Clin Microbiol 47:3439-43. 2009
    ..1 +/- 17.8 years) were included. Of these, 550 were patients hospitalized for acute febrile lower respiratory tract infections and 450 were controls...
  61. ncbi Predicting the clinical course of suspected acute viral upper respiratory tract infection in children
    Christopher C Butler
    Department of General Practice, Cardiff University, Llanedeyrn Health Centre, Cardiff CF23 9PN, UK
    Fam Pract 22:92-5. 2005
    ....
  62. ncbi Macrophage defences against respiratory tract infections
    S B Gordon
    Wellcome Trust Research Laboratory, University of Malawi, Queen Elizabeth Central Hospital, Blantyre, Malawi
    Br Med Bull 61:45-61. 2002
    ..Macrophage function can be modulated by cytokines, environmental exposures, recent and chronic infection including HIV infection, drug therapy and gene transfer...
  63. pmc Real-time reverse transcription-PCR assay for comprehensive detection of human rhinoviruses
    Xiaoyan Lu
    Gastroenteritis and Respiratory Virus Laboratory Branch, Division of Viral Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    J Clin Microbiol 46:533-9. 2008
    ..The assay was successfully applied in an investigation of a coincidental outbreak of HRV respiratory illness among laboratory staff...
  64. ncbi Effectiveness of influenza vaccination of children with recurrent respiratory tract infections in reducing respiratory-related morbidity within the households
    Susanna Esposito
    Department of Pediatric I, University of Milan, Via Commenda 9, 20122, Milan, Italy
    Vaccine 21:3162-8. 2003
    ..of influenza vaccination in reducing respiratory-related morbidity among children with recurrent respiratory tract infections (RRTIs) and their household contacts, 127 children aged 6 months-9 years (78 males; median age, 3...
  65. pmc Effect of long term consumption of probiotic milk on infections in children attending day care centres: double blind, randomised trial
    K Hatakka
    Valio Research and Development, PO Box 30, FIN-00039 Valio, Helsinki, Finland
    BMJ 322:1327. 2001
    ..of days with respiratory and gastrointestinal symptoms, absences from day care because of illness, respiratory tract infections diagnosed by a doctor, and course of antibiotics...
  66. ncbi Maternal vitamin D status in pregnancy and risk of lower respiratory tract infections, wheezing, and asthma in offspring
    Eva Morales
    Center for Research in Environmental Epidemiology, Barcelona, Catalonia, Spain
    Epidemiology 23:64-71. 2012
    ..We assessed whether maternal circulating 25-hydroxyvitamin D (25[OH]D) concentrations in pregnancy are associated with risk of lower respiratory tract infections, wheezing, and asthma in the offspring.
  67. pmc Human respiratory syncytial virus in children with acute respiratory tract infections in China
    Rong Fang Zhang
    School of Basic Medical Sciences of Lanzhou University, Lanzhou 730000, China
    J Clin Microbiol 48:4193-9. 2010
    ..and molecular characterization of human respiratory syncytial virus (HRSV) in children with acute respiratory tract infections (ARTIs) in China...
  68. pmc Genetic variability in the G protein gene of group A and B respiratory syncytial viruses from India
    Shama Parveen
    Department of Microbiology, All India Institute of Medical Sciences, New Delhi 110029, India
    J Clin Microbiol 44:3055-64. 2006
    ..78) than within the genotypes (dN/dS, 0.69). These are among the first molecular analyses of RSV strains from the second most populous country in the world and will be useful for comparisons to candidate vaccine strains...
  69. ncbi Virological features and clinical manifestations associated with human metapneumovirus: a new paramyxovirus responsible for acute respiratory-tract infections in all age groups
    Guy Boivin
    Research Center in Infectious Diseases, Regional Virology Laboratory, Laval University, Quebec City, Canada
    J Infect Dis 186:1330-4. 2002
    ..These findings suggest that HMPV can be associated with severe lower-respiratory-tract infections in very young children, the elderly, and immunocompromised patients...
  70. pmc Variations in antibiotic prescribing and consultation rates for acute respiratory infection in UK general practices 1995-2000
    Mark Ashworth
    STaRNet lead general practitioner and honorary senior lecturer, King s College London
    Br J Gen Pract 55:603-8. 2005
    ..Antibiotic prescribing by GPs in the UK has declined since 1995...
  71. ncbi Clinical disease in children associated with newly described coronavirus subtypes
    Jane Kuypers
    Department of Laboratory Medicine, University of Washington, Seattle, Washington, USA
    Pediatrics 119:e70-6. 2007
    ..In this study we examined the prevalence of 4 human coronaviruses, including subtypes OC43, 229E, and the recently described NL63 and HKU1 in a pediatric population presenting to a children's hospital...
  72. ncbi Anthrax as a biological weapon, 2002: updated recommendations for management
    Thomas V Inglesby
    Johns Hopkins Center for Civilian Biodefense Strategies, Johns Hopkins University, Baltimore, MD 21202, USA
    JAMA 287:2236-52. 2002
    ..To review and update consensus-based recommendations for medical and public health professionals following a Bacillus anthracis attack against a civilian population...
  73. ncbi Procalcitonin for guidance of antibiotic therapy
    Philipp Schuetz
    Harvard School of Public Health, MA, USA
    Expert Rev Anti Infect Ther 8:575-87. 2010
    ..This review aims to provide physicians with an overview of the strengths and limitations of procalcitonin guidance for antibiotic therapy when used in different clinical settings and in patients with different underlying infections...
  74. ncbi Simultaneous detection of fourteen respiratory viruses in clinical specimens by two multiplex reverse transcription nested-PCR assays
    M T Coiras
    Laboratorio de Virus Respiratorios, Servicio de Virologia, Centro Nacional de Microbiologia, Instituto de Salud Carlos III, Madrid, Spain
    J Med Virol 72:484-95. 2004
    There is a need for rapid, sensitive, and accurate diagnosis of lower respiratory tract infections in children, elderly, and immunocompromised patients, who are susceptible to serious complications...
  75. pmc Effect of point of care testing for C reactive protein and training in communication skills on antibiotic use in lower respiratory tract infections: cluster randomised trial
    Jochen W L Cals
    Department of General Practice, CAPHRI School for Public Health and Primary Care, Maastricht University Medical Centre, PO Box 616, 6200 MD Maastricht, Netherlands
    BMJ 338:b1374. 2009
    ..To assess the effect of general practitioner testing for C reactive protein (disease approach) and receiving training in enhanced communication skills (illness approach) on antibiotic prescribing for lower respiratory tract infection...
  76. ncbi Understanding the mechanisms of viral induced asthma: new therapeutic directions
    Nicole G Hansbro
    Priority Research Centre for Asthma and Respiratory Disease, Faculty of Health, The University of Newcastle, New South Wales 2308, Australia
    Pharmacol Ther 117:313-53. 2008
    ..b>Respiratory tract infections by respiratory syncytial virus (RSV) and rhinovirus (RV) are widely implicated as common causes of the ..
  77. pmc Identification of a third human polyomavirus
    Tobias Allander
    Laboratory for Clinical Microbiology, Department of Clinical Microbiology, Tumor and Cell Biology, L2 02, Karolinska University Hospital, SE 171 76 Stockholm, Sweden
    J Virol 81:4130-6. 2007
    ..This finding further illustrates how unbiased screening of respiratory tract samples can be used for the discovery of diverse virus types...
  78. ncbi Comparison of nasopharyngeal flocked swabs and aspirates for rapid diagnosis of respiratory viruses in children
    K H Chan
    Department of Microbiology, The University of Hong Kong and Queen Mary Hospital, Hong Kong SAR, China
    J Clin Virol 42:65-9. 2008
    ..The quality of clinical specimens is a crucial determinant for virological diagnosis...
  79. ncbi [Viral etiology of 1165 hospitalized children with acute lower respiratory tract infection]
    Ni guang Xiao
    Department of Pediatrics, People s Hospital of Hunan Province, Changsha 410005, China
    Zhongguo Dang Dai Er Ke Za Zhi 14:28-32. 2012
    ..To explore the viral etiology of acute low respiratory tract infection (ALRTI) among hospitalized children in Changsha of Hunan Province of China...
  80. pmc Health Alliance for prudent antibiotic prescribing in patients with respiratory tract infections (HAPPY AUDIT) -impact of a non-randomised multifaceted intervention programme
    Lars Bjerrum
    Research Unit for General Practice and Section of General Practice, Department of Public Health, University of Copenhagen, Copenhagen, Denmark
    BMC Fam Pract 12:52. 2011
    ..The aim of this study was to evaluate the impact of a multifaceted intervention targeting general practitioners (GPs) and patients in six countries with different health organization and different prevalence of antibiotic resistance...
  81. ncbi Haemophilus haemolyticus: a human respiratory tract commensal to be distinguished from Haemophilus influenzae
    Timothy F Murphy
    Department of Medicine, University at Buffalo, State University of New York, Buffalo, NY, USA
    J Infect Dis 195:81-9. 2007
    ..In a prospective study, selected isolates of apparent H. influenzae had an altered phenotype. We tested the hypothesis that these variant strains were genetically different from typical H. influenzae...
  82. pmc Viral and atypical bacterial detection in acute respiratory infection in children under five years
    Patrícia G M Bezerra
    Instituto de Medicina Integral Professor Fernando Figueira IMIP, Recife, Brazil
    PLoS ONE 6:e18928. 2011
    ..This study aimed to determine the viral and atypical bacterial causes of different severities and clinical manifestations of ARI in preschool children from low-income families in North-East Brazil...
  83. ncbi Genetic diversity of human metapneumovirus over 4 consecutive years in Australia
    Ian M Mackay
    Queensland Paediatric Infectious Disease Laboratory, Royal Children s Hospital, University of Queensland, Queensland, Australia
    J Infect Dis 193:1630-3. 2006
    ..chain reaction was used to screen 10,319 specimens from patients presenting to hospitals with suspected respiratory tract infections during 2001-2004...
  84. pmc Characterization of the viral microbiome in patients with severe lower respiratory tract infections, using metagenomic sequencing
    Fredrik Lysholm
    IFM Bioinformatics and Swedish e Science Research Centre SeRC, Linkoping University, Linkoping, Sweden
    PLoS ONE 7:e30875. 2012
    ..to the Karolinska University Laboratory, Stockholm, Sweden from March 2004 to May 2005 for diagnosis of respiratory tract infections. We have used a metagenomic sequencing strategy to characterize viruses, as this provides the most ..
  85. pmc Relative importance of nasopharyngeal versus oropharyngeal sampling for isolation of Streptococcus pneumoniae and Haemophilus influenzae from healthy and sick individuals varies with age
    David Greenberg
    The Pediatric Infectious Disease Unit, Ben Gurion University of the Negev, Soroka University Medical Center, Beer Sheva, Israel
    J Clin Microbiol 42:4604-9. 2004
    ..Culturing only one site significantly reduced the recovery of H. influenzae at all ages. NP cultures for S. pneumoniae detected close to 100% of isolates in children but only 58% of isolates in mothers...
  86. ncbi Prevalence and clinical symptoms of human metapneumovirus infection in hospitalized patients
    Bernadette G van den Hoogen
    Department of Virology, Erasmus Medical Center, Rotterdam, The Netherlands
    J Infect Dis 188:1571-7. 2003
    ..Treatment with antibiotics and corticosteroids was reported more frequently in hMPV-infected children. From these data, we conclude that hMPV is an important pathogen associated with RTI...
  87. ncbi Prevalence of human respiratory viruses in adults with acute respiratory tract infections in Beijing, 2005-2007
    L Ren
    Dr Christophe Mérieux Laboratory, IPB, CAMS Fondation Mérieux and State Key Laboratory for Molecular Virology and Genetic Engineering, Institute of Pathogen Biology IPB, Chinese Academy of Medical Sciences CAMS, Beijing, China
    Clin Microbiol Infect 15:1146-53. 2009
    ..the aetiological role and epidemiological profile of common respiratory viruses in adults with acute respiratory tract infections (ARTIs), a 2-year study was conducted in Beijing, China, from May 2005 to July 2007...
  88. pmc Etiology and clinical characterization of respiratory virus infections in adult patients attending an emergency department in Beijing
    Xiaoyan Yu
    Key Laboratory for Laboratory Medicine of Ministry of Education, Institute of Medical Virology, Wenzhou Medical College, Wenzhou, Zhejiang, China
    PLoS ONE 7:e32174. 2012
    Acute respiratory tract infections (ARTIs) represent a serious global health burden. To date, few reports have addressed the prevalence of respiratory viruses (RVs) in adults with ARTIs attending an emergency department (ED)...
  89. ncbi Prevalence of human metapneumovirus in adults with acute respiratory tract infection in Beijing, China
    Jianguo Li
    State Key Laboratory of Molecular Virology and Genetic Engineering, Institute of Pathogen Biology IPB, Peking Union Medical College PUMC and Chinese Academy of Medical Sciences CAMS, 9 Dong Dan San Tiao, Dongcheng District, Beijing 100730, PR China
    J Infect 64:96-103. 2012
    To evaluate the prevalence and clinical manifestations of human metapneumovirus (hMPV) in immunocompetent Chinese adults with acute respiratory tract infections (ARTIs).
  90. ncbi Lactobacillus GG in the prevention of gastrointestinal and respiratory tract infections in children who attend day care centers: a randomized, double-blind, placebo-controlled trial
    Iva Hojsak
    Referral Center for Pediatric Gastroenterology and Nutrition, Children s Hospital Zagreb, Klaiceva 16, Zagreb, Croatia
    Clin Nutr 29:312-6. 2010
    The aim of our study was to investigate the role of Lactobacillus GG (LGG) in the prevention of gastrointestinal and respiratory tract infections in children who attend day care centers.
  91. ncbi Role of emerging respiratory viruses in children with severe acute wheezing
    M L García-García
    Pediatrics Department, Severo Ochoa Hospital, Madrid, Spain
    Pediatr Pulmonol 45:585-91. 2010
    ..Acute wheezing episodes are frequently associated with respiratory viral infections in children. However, the role of the recently described respiratory viruses is not yet fully understood...
  92. ncbi Human bocavirus in children: mono-detection, high viral load and viraemia are associated with respiratory tract infection
    Andreas Christensen
    Department of Medical Microbiology, St Olavs Hospital, Trondheim University Hospital, Trondheim, Norway
    J Clin Virol 49:158-62. 2010
    Human bocavirus 1 (HBoV1) has recently been detected in children with respiratory tract infections (RTI)...
  93. ncbi Human metapneumovirus infections in young and elderly adults
    Ann R Falsey
    Infectious Diseases Unit, Rochester General Hospital, University of Rochester School of Medicine and Dentistry, 1425 Portland Avenue, Rochester, NY 14621, USA
    J Infect Dis 187:785-90. 2003
    ..In conclusion, hMPV infection occurs in adults of all ages and may account for a significant portion of persons hospitalized with respiratory infections during some years...
  94. ncbi Upsurge of human enterovirus 68 infections in patients with severe respiratory tract infections
    Janette Rahamat-Langendoen
    Department of Medical Microbiology, Division of Clinical Virology, University Medical Center Groningen, The Netherlands
    J Clin Virol 52:103-6. 2011
    ..During the autumn of 2010, we noticed an upsurge of EV68 infections in the Northern part of the Netherlands in patients with severe respiratory illness...
  95. ncbi Two-year prospective study of single infections and co-infections by respiratory syncytial virus and viruses identified recently in infants with acute respiratory disease
    Filippo Canducci
    Laboratorio di Microbiologia e Virologia, Universita Vita Salute San Raffaele, and Istituto Scientifico San Raffaele, Milan, Italy
    J Med Virol 80:716-23. 2008
    ....
  96. ncbi Upper respiratory tract infection is reduced in physically fit and active adults
    David C Nieman
    Human Performance Laboratory, Appalachian State University, North Carolina Research Campus, Kannapolis, NC 28081, USA
    Br J Sports Med 45:987-92. 2011
    ..The purpose of this study was to monitor URTI symptoms and severity in a heterogeneous group of community adults and contrast across tertiles of physical activity and fitness levels while adjusting for potential confounders...
  97. ncbi Rapid detection and identification of 12 respiratory viruses using a dual priming oligonucleotide system-based multiplex PCR assay
    Suk Ran Kim
    Department of Laboratory Medicine and Genetics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea
    J Virol Methods 156:111-6. 2009
    ..The Seeplex Respiratory Virus Detection assay represents a significant improvement over the conventional methods for the detection of a broad spectrum of respiratory viruses...
  98. ncbi Biomarkers in respiratory tract infections: diagnostic guides to antibiotic prescription, prognostic markers and mediators
    M Christ-Crain
    Department of Internal Medicine, University Hospital Basel, Petersgraben 4, CH 4031 Basel, Switzerland
    Eur Respir J 30:556-73. 2007
    Used appropriately, biomarkers improve the assessment of respiratory tract infections and sepsis. Most prominently, circulating procalcitonin levels increase by a factor of several tens of thousands during sepsis...
  99. pmc Comparison of nasopharyngeal and oropharyngeal swabs for the diagnosis of eight respiratory viruses by real-time reverse transcription-PCR assays
    Curi Kim
    U S Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America
    PLoS ONE 6:e21610. 2011
    ..Many acute respiratory illness surveillance systems collect and test nasopharyngeal (NP) and/or oropharyngeal (OP) swab specimens, yet there are few studies assessing the relative measures of performance for NP versus OP specimens...
  100. pmc High burden of non-influenza viruses in influenza-like illness in the early weeks of H1N1v epidemic in France
    Nathalie Schnepf
    Universite Paris Diderot, Sorbonne Paris Cité, Microbiology Department, Saint Louis Hospital, APHP, Paris, France
    PLoS ONE 6:e23514. 2011
    ..Clinical observations are of little help to recognise myxovirus infection and implement appropriate prevention measures. The limited use of molecular tools underestimates the role of other common pathogens...
  101. pmc Application of TaqMan low-density arrays for simultaneous detection of multiple respiratory pathogens
    Maja Kodani
    Division of Bacterial Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    J Clin Microbiol 49:2175-82. 2011
    ..The TLDA card approach offers promise for rapid and simultaneous identification of multiple respiratory pathogens for outbreak investigations and disease surveillance...

Research Grants76

  1. Effect of PPARy Ligands on Alcohol-Induced Alveolar Macrophage Oxidative Stress
    Samantha M Yeligar; Fiscal Year: 2013
    ..Thus, this K99/R00 application provides an excellent opportunity to advance the career of a talented and promising investigator. ..
  2. Nanoparticle Coupled Antioxidants for Respiratory Illness in Veterans
    RODNEY JON SCHLOSSER; Fiscal Year: 2013
    ..Even minor upper respiratory tract infections are known to have a significant impact on military operations2 and concern has been raised about a ..
  3. Community Participation Research of Breastfeeding Disparities in African American
    Tamar Ringel Kulka; Fiscal Year: 2009
    ..show that children who are not breastfed suffer increased health problems such as ear infections, lower respiratory tract infections, skin rashes similar to eczema, asthmatic episodes, type I and type II diabetes, episodes of infant ..
  4. Pilot Studies of the Effect of Aging on Mucociliary Clearance
    Lawrence E Ostrowski; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Respiratory tract infections are a major cause of morbidity and mortality in the elderly population...
  5. Lung VITamin D and OmegA-3 TriaL (Lung VITAL)
    Diane R Gold; Fiscal Year: 2013
    ..If vitamin D or marine omega-3 fatty acid supplementation reduce COPD and asthma exacerbations, reduce decline of lung function, improve asthma control and/or reduce pneumonia risk, this would be of great benefit to public health. ..
  6. Epidemiology and Etiology of Hospitalized Pneumonia in Children
    Krow Ampofo; Fiscal Year: 2010
    ..Understanding the frequency and etiology of bacterial infections following influenza will aid in pandemic planning. The data obtained from the proposed studies will be vital for evidence-based management of pneumonia in children. ..
  7. Pulmonary effects of biomass fuel indoor PM from rural India
    Shyam Biswal; Fiscal Year: 2013
    ..A/J mice were chosen because of their heightened sensitivity to airway challenges. ..
  8. Mechanisms and Enviromental Determinants of Rhinovirus Illness Severity
    James E Gern; Fiscal Year: 2013
    ..In this proposal, we will assemble a novel birth cohort to better farm effects on immune maturation and viral respiratory illnesses. The goal of this study is to identify new targets for the treatment and prevention of VRI. ..
  9. High Throughput Methods to Measure Disparities in Childhood Exposure to Tobacco
    Sharon E Murphy; Fiscal Year: 2010
    ....
  10. Interactions of Diesel Exhaust and Respiratory Viruses in Asthmatic Children
    Toby C Lewis; Fiscal Year: 2013
    ..2 million people in the United States, thus pointing the way towards targeted therapies and public health approaches. ..
  11. Repair of Airway Epithelium Following Chlorine Lung Injury
    Gary W Hoyle; Fiscal Year: 2011
    ..S. civilians could be adversely affected by highly toxic chemicals released intentionally in terrorist attacks or unintentionally in industrial accidents or natural disasters. ..
  12. Effect of Neonatal Hyperoxia on Alveolar Development and Infection
    MICHAEL A O'REILLY; Fiscal Year: 2012
    ..abstract_text> ..
  13. Moraxella catarrhalis: virulence-based prevention
    Timothy F Murphy; Fiscal Year: 2013
    ..by applicant): Moraxella catarrhalis is an important cause of otitis media in children, and lower respiratory tract infections (exacerbations) in adults with chronic obstructive pulmonary disease (COPD)...
  14. Otitis media-associated pneumococcal genes
    Honggao Yan; Fiscal Year: 2013
    ..pneumoniae. The bacterial genes identified in this project can be targeted to treat and prevent S. pneumoniae disease by disarming the immune evasion arsenals of S. pneumoniae through novel anti-bacterial drugs and vaccines. ..
  15. Mechanisms of oxidant-induced chronic bronchitis
    ROSANNA C MALBRAN FORTEZA; Fiscal Year: 2012
    ....
  16. Cigarette Smoke-derived Electrophilic Aldehydes and Airway Inflammation
    Albert van Der Vliet; Fiscal Year: 2013
    ....
  17. Respiratory Panel Flow-Strip: a Point-of-Care Molecular Diagnostic Test
    CHRISTOPHER GERARD COONEY; Fiscal Year: 2012
    ..This strategy has the potential to eliminate the burden of having to quickly develop and commercialize single-organism tests in response to an emerging pandemic. ..
  18. A Trial of Zinc and Micronutrients in Tanzanian Children
    Christopher P Duggan; Fiscal Year: 2010
    ..and blood smear for malaria. The primary outcomes will be the incidence of diarrhea and respiratory tract infections. Secondary outcomes will be weight and length gain...
  19. Cookstove Replacement for Prevention of ARI and Low Birthweight in Nepal
    JAMES MACK TIELSCH; Fiscal Year: 2012
    ..If the replacement of these stoves works to reduce respiratory infections and low birthweight, significant number of children's lives can be saved at very low cost. ..
  20. H. influenzae: Role of Sialic Acid in Virulence
    Michael A Apicella; Fiscal Year: 2013
    ..Finally, studies of isolates from human subjects colonized with NTHi 2019strR will examine the role of phase variation on LOS structure and determine if foreign DNA is acquired by NTHi during colonization. ..
  21. A+ Head Start Intervention for Smoke Free Homes
    Cynthia S Rand; Fiscal Year: 2012
    ....
  22. H. influenzae: Role of Sialic Acid in Virulence
    Michael Apicella; Fiscal Year: 2009
    ..abstract_text> ..
  23. Planning a clinical trial of Flash-heated breast milk to decrease morbidity, impr
    Caroline J Chantry; Fiscal Year: 2010
    ....
  24. Clinical Trial of Vitamin D3 to Reduce Cancer Risk in Postmenopausal Women
    Joan Lappe; Fiscal Year: 2013
    ..Positive findings will provide support for health policy changes to promote optimal vitamin D levels in the population. ..
  25. A Mucosal RSV Vaccine
    Kejian Yang; Fiscal Year: 2013
    ..syncytial virus (RSV) is a highly infectious member of the paramyxovirus family causing upper and lower respiratory tract infections. RSV infection is the leading cause of pulmonary disease of the lower respiratory tract (bronchiolitis, ..
  26. Functional and Lymphocytic Markers of Respiratory Morbidity in Hyperoxic Preemies
    RITA MARIE RYAN; Fiscal Year: 2013
    ..The future of many vulnerable children depends on this pioneering approach to the Prematurity and Respiratory Outcomes Program, PROP. ..
  27. Neutrophil Accumulation in Bacterial Pneumonia
    Samithamby Jeyaseelan; Fiscal Year: 2013
    ....
  28. Long-lived B cell Immunity in the Respiratory Tract
    Nicole Baumgarth; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Respiratory tract infections induce strong and long-lasting humoral immune responses locally at the site, contributing significantly to immune protection from challenge infection...
  29. Yeast Based Assays for Chemical Screens Against SARS-CoV Targets
    DANIEL A contact ENGEL; Fiscal Year: 2010
    ..of four antigenically distinct viruses that are important human pathogens that cause upper and lower respiratory tract infections. In young children and the elderly, lower respiratory tract infections can be severe...
  30. Point of care microfluidic diagnosis system for rapid and sensitive detection of
    Michel G Bergeron; Fiscal Year: 2013
    ..platform will result in an unprecedented expansion of point-of-care diagnostic tests (POCTs) for viral respiratory tract infections, while providing rapid yet economical molecular diagnostics results in less than one hour instead of ..
  31. Longitudinal Studies of HIV-Associated Bacterial Pneumonia
    William N Rom; Fiscal Year: 2013
    ..We will freeze and store at -70 degrees plasma, serum, PBMC (RNA, DNA, protein), BAL, from involved/uninvolved lung segments, and sputum for collaborative studies with other NHLBI grantees. ..
  32. The Effects of Fatty Acid Ethyl Esters on the Developing Lung
    SOWMYA S MOHAN; Fiscal Year: 2010
    ..These results could elucidate whether prenatal alcohol exposure adds to the premature newborn's already increased risk for infection and lung injury. ..
  33. Regulation of B Lymphocyte Defects in Senescent Humans
    Bonnie B Blomberg; Fiscal Year: 2013
    ..with a primary (genetic) immune deficiency in CSR have severe immune complications including respiratory tract infections, autoimmunity and failure to respond to vaccination...
  34. Role of TLR4 in Coronavirus Infection
    Steven M Varga; Fiscal Year: 2010
    ..Human coronaviruses cause respiratory tract infections in humans that can result in mild disease similar to the common cold as well as potentially fatal cases ..
  35. TSLP and Childhood Asthma
    Steven F Ziegler; Fiscal Year: 2012
    ..Respiratory Syncytial virus (RSV) is the most important cause of lower respiratory tract infections in infants and young children...
  36. IRON ACQUISITION IN BORDETELLA PERTUSSIS
    SANDRA KAY ARMSTRONG; Fiscal Year: 2013
    ..This increased understanding may lead to improved strategies to prevent growth of these, and other respiratory pathogens, in humans. ..
  37. Host defense against influenza virus in the lungs of neonatal mice
    Beth A Garvy; Fiscal Year: 2010
    ..Understanding the nature of the failure of the neonatal immune system to control influenza virus is important for generation of new vaccine and treatment strategies. ..
  38. Enhancing neutrophil function in neutropenia-related pneumonia
    Hongbo R Luo; Fiscal Year: 2012
    ..In addition, since alveolar macrophages also play a critical rolein host defense against respiratory tract infections, whether disruption of PTEN can also enhance the function of alveolar macrophages will be investigated (..
  39. Pilot Studies of Gene Therapy for Primary Ciliary Dyskinesia
    Lawrence E Ostrowski; Fiscal Year: 2010
    ..The information gained from these studies will advance the field of gene therapy and may be useful to the treatment of many genetic diseases. ..
  40. Waterless hand sanitizer for diarrhea prevention in a humanitarian emergency
    Pavani Kalluri Ram; Fiscal Year: 2013
    ..This innovative study will inform public health approaches to prevent unconscionably high rates of diarrhea mortality among young children affected by humanitarian emergencies. ..
  41. Chronic alcohol and pulmonary immunity
    Kevin L Legge; Fiscal Year: 2010
    ..Literature Cited..,.. 229-234 9. Consortium/Contractual Arrangements N/A 10. Consultants/Collaborators 234 11. Letters of Support 235-239 Appendices on CD: 5 Publications PHS 398 (Rev. 04/06) Page 202 Fonn Page 3 ..
  42. Pathogenic Mechanism for Lung Infection in Mucoid Pseudomonas
    DENNIS EDWARD OHMAN; Fiscal Year: 2013
    ..aeruginosa infections. The results of these studies will also contribute to our overall understanding of bacterial capsule biosynthesis, which is a common mechanism of bacterial virulence for avoiding the host immune response. ..
  43. Intervening to Improve Birth Weight and Infant Respiratory Health in Rural Ghana
    PATRICK LOTT KINNEY; Fiscal Year: 2013
    ..The proposed research will carefully examine the benefits of an intervention to improve infant birth weight and respiratory health in rural Ghana. ..
  44. Oral Health Intervention for Intellectually/Developmentally Disabled Persons
    KNOWLTON WILLIAM JOHNSON; Fiscal Year: 2012
    ..Ultimately, the results could impact healthcare reform and integrate dental case management into medical case management for disadvantaged persons. ..
  45. RANDOMIZED TRIAL: MATERNAL VITAMIN D SUPPLEMENTATION TO PREVENT CHILDHOOD ASTHMA
    Scott T Weiss; Fiscal Year: 2013
    ..in the child of (a) allergic sensitization, (b) doctor's diagnosis of eczema and (c) lower respiratory tract infections during the first 3 years of life;and (2) To determine whether adequate vitamin D supplementation in the ..
  46. RANDOMIZED TRIAL: MATERNAL VITAMIN D SUPPLEMENTATION TO PREVENT CHILDHOOD ASTHMA
    Robert Strunk; Fiscal Year: 2013
    ..in the child of (a) allergic sensitization, (b) doctor's diagnosis of eczema and (c) lower respiratory tract infections during the first 3 years of life;and (2) To determine whether adequate vitamin D supplementation in the ..
  47. Genetic Analysis of Molecular Interactions in Coronavirus Replication
    PAUL SCOTT MASTERS; Fiscal Year: 2013
    ..In humans, four coronaviruses are responsible for common upper respiratory tract infections;a fifth human coronavirus is the causative agent of severe acute respiratory syndrome (SARS), which has ..
  48. 9th International Symposium on Bordetella
    Nicholas H Carbonetti; Fiscal Year: 2010
    ..Support for trainees to attend and participate in the meeting is essential for development of new investigators in this field. ..
  49. Collectins and Innate Defense against Inhaled Pathogens
    Barbara A Seaton; Fiscal Year: 2010
    ....
  50. Vitamin D and Innate Immunity in Respiratory Infections
    Gill Diamond; Fiscal Year: 2013
    ..This application is appropriate for the R21 mechanism because it involves considerable risk but may lead to a breakthrough in vitamin D and innate immunity that could have a major impact on research in the field of airway infections. ..
  51. ALLOANTIBODIES TO MHC INDUCES AUTOIMMUNITY AND OBLITERATIVE AIRWAY DISEASE (OAD)
    Thalachallour Mohanakumar; Fiscal Year: 2012
    ....
  52. Mast cell dependent inflammatory cascade during influenza A virus infection
    Joshua J Obar; Fiscal Year: 2013
    ....
  53. Co-infections of rhinovirus and bacteria in chronic lung disorders
    UMADEVI SIVANAPPA SAJJAN; Fiscal Year: 2010
    ..airway epithelial cell cultures with rhinovirus (RV), the virus responsible for most respiratory tract infections, increases binding of both non- typeable Hemophilus influenzae (NTHI) and Pseudomonas aeruginosa (PA), ..
  54. Role of anti-SARS-CoV T cell response in pathogenesis
    Stanley Perlman; Fiscal Year: 2013
    ..Identification of rDC defects as critical in the increased susceptibility to viral respiratory infections will provide a novel therapeutic target in infected patients. ..
  55. Transgenerational exposures as modifiers of host defense against infection
    B Paige Lawrence; Fiscal Year: 2013
    ....
  56. Encapsidation of Adenovirus DNA
    Michael J Imperiale; Fiscal Year: 2010
    ..This knowledge will be applicable to the development of anti-viral drugs that block this process, as well as to the development of safer adenovirus vectors and recombinant vaccines. ..
  57. Viral Pathogenesis of Early Cystic Fibrosis Lung Disease
    SARATH CHANDRA RANGANATHAN; Fiscal Year: 2013
    ..nucleic acid-based detection and powerful microbiomic assays will be used to characterize lower respiratory tract infections. Also, we will systematically define the earliest physiological changes in the CF lung, combining ..
  58. Chronic Ethanol Consumption and Pulmonary Immune Suppression
    Kevin L Legge; Fiscal Year: 2013
    ..Furthermore, the insights learned from this application hold the potential to suggest methodologies to restore and/or boost immunity in chronic alcoholics during these diseases. ..
  59. Preventing Nosocomial Respiratory Infections: Patient Safety in the ICU
    Elizabeth Lee Daugherty; Fiscal Year: 2013
    ....
  60. Lipid Effector Molecules of Innate Immunity: Antimicrobial Cholesteryl Esters
    Edith Porter; Fiscal Year: 2013
    ..Last, not least, this research may lead to the discovery of novel virulence factors of pathogenic microbes that circumvent host defenses mediated by antimicrobial lipids in the respiratory tract and on other mucosal surfaces. ..
  61. Regulation and Function of Immunoglobulin D in Mucosal Immune Defense
    Andrea Cerutti; Fiscal Year: 2013
    ..It will also support the use of vitamin D modifying regimens in treating immunopathologies and establish that more effective vaccination strategies against respiratory pathogens should actively boost IgD responses. ..
  62. Enhanced Surveillance for New Vaccine Preventable Diseases
    Mary A Staat; Fiscal Year: 2010
    ..Providing accurate rates of intussusception (IS), a potential adverse event of rotavirus vaccine is also addressed in this application (objective 14-30). ..
  63. Mulago Inpatient Noninvasive Diagnosis of Pneumocystis Pneumonia (MIND PCP) Study
    John Davis; Fiscal Year: 2007
    ..This study will test if DNA- fingerprinting of special mouthwashes can accurately diagnose HIV-related pneumonia, and save lives. [unreadable] [unreadable] [unreadable]..
  64. Transmission and the respiratory tract in cryptosporidiosis
    Jeffrey Griffiths; Fiscal Year: 2007
    ..This proposal will explore the contribution, if any, of Cryptosporidiosis to respiratory tract infections. We hypothesize, based on a wealth of data (circumstantial information, human case reports and case ..
  65. Evaluation of Wire Electrodes to Activate the Expiratory Muscles to Restore Cough
    Anthony F DiMarco; Fiscal Year: 2010
    ..facilitates secretion removal, reduces the need for caregiver support, reduces the incidence of respiratory tract infections and improves life quality...
  66. PASTEURELLA MULTOCIDA TOXIN--STRUCTURE AND ACTIVITY
    Brenda Wilson; Fiscal Year: 2000
    ..3) To test the hypothesis that PMT uncouples the ligand-regulated interaction between receptor and Gq-protein, using the Xenopus oocyte system overexpressing exogenous 5-HT2 receptor and Gqalpha-protein. ..
  67. Measuring the Cost of Environmental Health Risks: Evidence from Neighborhoods Nea
    LUCAS W DAVIS; Fiscal Year: 2010
    ..The study is relevant for evaluating a wide range of environmental and health policies that affect when, where, and how power plants are sited as well as what steps should be taken to mitigate the associated health impacts. ..
  68. Adenovirus Persistence in Human Lymphoid Tissues
    Linda Gooding; Fiscal Year: 2007
    The subgroup C adenoviruses cause respiratory tract infections in young children leading to episodic virus shedding for months to years after primary infection...
  69. Spinal Cord Stimulation to Restore Cough In Humans
    Anthony DiMarco; Fiscal Year: 2007
    ..ability to clear airway secretions, a factor which contributes to their development of recurrent respiratory tract infections and atelectasis and attendant high morbidity and mortality...
  70. Oral & Respiratory Status of Retarded/Disabled Persons
    Catherine Binkley; Fiscal Year: 2005
    b>Respiratory tract infections are the primary causes of death in institutionalized mentally retarded and developmental disabled (MRDD) persons...
  71. Emerging Macrolide Resistance in Mycoplasma Pneumoniae
    THOMAS PRESCOTT ATKINSON; Fiscal Year: 2010
    ..We propose to conduct a prospective study in children using traditional culture and molecular-based methods to test for antibiotic resistance in M. pneumoniae. ..
  72. MECHANISM OF CIGARETTE SMOKE-INDUCED IMMUNOSUPPRESSION
    Mohan Sopori; Fiscal Year: 2003
    ..Additionally, the results may provide insight into the mechanism of T cell tolerance and neuroimmune interactions. ..
  73. RNA editing and its inhibition of HIV-1 replication in human macrophage
    Yoshihiko Hoshino; Fiscal Year: 2007
    unreadable] DESCRIPTION (provided by applicant): Drug abusers have high rates of respiratory tract infections and are accelerated progression of AIDS, suggesting host immune defense is down-regulated in this group of patients...
  74. Supporting New Faculty Recruitment Through Biomedical Research Core Center
    David H Ingbar; Fiscal Year: 2010
    ..Dr Williams's research brings an innovative approach to understanding and decreasing Pseudomonas infection in CF patients. ..
  75. IDENTIFICATION OF BIOCHEMICAL ABNORMALITIES IN PCD CILIA
    LAWRENCE OSTROWSKI; Fiscal Year: 2002
    ..Further studies of the role of these proteins in the assembly and function of cilia may also result in improved treatment for other air way diseases. ..
  76. Development, Implementation and Evaluation of Novel Strategies to Reduce Inapprop
    JOSHUA P contact METLAY; Fiscal Year: 2010
    ..Among humans, the vast majority of unnecessary antibiotic prescriptions are used to treat acute respiratory tract infections (ARIs) that have a viral etiology...