airway obstruction

Summary

Summary: Any hindrance to the passage of air into and out of the lungs.

Top Publications

  1. ncbi The nature of small-airway obstruction in chronic obstructive pulmonary disease
    James C Hogg
    University of British Columbia, the Centre for Cardiovascular and Pulmonary Research, and St Paul s Hospital, Vancouver, Canada
    N Engl J Med 350:2645-53. 2004
  2. pmc Small-airway obstruction and emphysema in chronic obstructive pulmonary disease
    John E McDonough
    University of British Columbia James Hogg Research Centre, St Paul s Hospital, Vancouver, BC, Canada
    N Engl J Med 365:1567-75. 2011
  3. pmc Airway smooth muscle dynamics: a common pathway of airway obstruction in asthma
    S S An
    Division of Physiology, Dept of Environmental Health Sciences, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, USA
    Eur Respir J 29:834-60. 2007
  4. ncbi The body-mass index, airflow obstruction, dyspnea, and exercise capacity index in chronic obstructive pulmonary disease
    Bartolome R Celli
    COPD Center at St Elizabeth s Medical Center, Tufts University School of Medicine, Boston, MA 02135, USA
    N Engl J Med 350:1005-12. 2004
  5. ncbi Airway obstruction in never smokers: results from the Third National Health and Nutrition Examination Survey
    Bartolome R Celli
    Caritas St Elizabeth s Medical Center, Tufts University Medical School, Boston, Mass, USA
    Am J Med 118:1364-72. 2005
  6. doi Lung hyperinflation and its reversibility in patients with airway obstruction of varying severity
    Athavudh Deesomchok
    Department of Medicine, Queen s University and Kingston General Hospital, Kingston, Ontario, Canada
    COPD 7:428-37. 2010
  7. pmc Emphysema--a disease of small airways or lung parenchyma?
    Wayne Mitzner
    N Engl J Med 365:1637-9. 2011
  8. doi Airway management in children with mucopolysaccharidoses
    Andrea H Yeung
    Department of Otolaryngology Head and Neck Surgery, University of California, San Francisco, 400 Parnassus Ave, A730, San Francisco, CA 94143 0342, USA
    Arch Otolaryngol Head Neck Surg 135:73-9. 2009
  9. pmc Upper airways abnormalities and tracheal problems in Morquio's disease
    P P Walker
    Department of Respiratory Medicine, University Hospital Aintree, Liverpool, UK
    Thorax 58:458-9. 2003
  10. pmc Relationship between peripheral airway dysfunction, airway obstruction, and neutrophilic inflammation in COPD
    R A O'Donnell
    Respiratory Cell and Molecular Biology, Division of Infection, Inflammation and Repair, University of Southampton, Southampton General Hospital, Southampton SO16 6YD, UK
    Thorax 59:837-42. 2004

Detail Information

Publications361 found, 100 shown here

  1. ncbi The nature of small-airway obstruction in chronic obstructive pulmonary disease
    James C Hogg
    University of British Columbia, the Centre for Cardiovascular and Pulmonary Research, and St Paul s Hospital, Vancouver, Canada
    N Engl J Med 350:2645-53. 2004
    ..We examined the evolution of the pathological effects of airway obstruction in patients with COPD.
  2. pmc Small-airway obstruction and emphysema in chronic obstructive pulmonary disease
    John E McDonough
    University of British Columbia James Hogg Research Centre, St Paul s Hospital, Vancouver, BC, Canada
    N Engl J Med 365:1567-75. 2011
    ..We wanted to determine whether there was a relationship between small-airway obstruction and emphysematous destruction in COPD.
  3. pmc Airway smooth muscle dynamics: a common pathway of airway obstruction in asthma
    S S An
    Division of Physiology, Dept of Environmental Health Sciences, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, USA
    Eur Respir J 29:834-60. 2007
    Excessive airway obstruction is the cause of symptoms and abnormal lung function in asthma...
  4. ncbi The body-mass index, airflow obstruction, dyspnea, and exercise capacity index in chronic obstructive pulmonary disease
    Bartolome R Celli
    COPD Center at St Elizabeth s Medical Center, Tufts University School of Medicine, Boston, MA 02135, USA
    N Engl J Med 350:1005-12. 2004
    ..We hypothesized that a multidimensional grading system that assessed the respiratory and systemic expressions of COPD would better categorize and predict outcome in these patients...
  5. ncbi Airway obstruction in never smokers: results from the Third National Health and Nutrition Examination Survey
    Bartolome R Celli
    Caritas St Elizabeth s Medical Center, Tufts University Medical School, Boston, Mass, USA
    Am J Med 118:1364-72. 2005
    ..COPD is rarely considered in persons with no smoking history except in the context of another exposure. Accordingly, the disease has not been well characterized in these "never smokers."..
  6. doi Lung hyperinflation and its reversibility in patients with airway obstruction of varying severity
    Athavudh Deesomchok
    Department of Medicine, Queen s University and Kingston General Hospital, Kingston, Ontario, Canada
    COPD 7:428-37. 2010
    The natural history of lung hyperinflation in patients with airway obstruction is unknown...
  7. pmc Emphysema--a disease of small airways or lung parenchyma?
    Wayne Mitzner
    N Engl J Med 365:1637-9. 2011
  8. doi Airway management in children with mucopolysaccharidoses
    Andrea H Yeung
    Department of Otolaryngology Head and Neck Surgery, University of California, San Francisco, 400 Parnassus Ave, A730, San Francisco, CA 94143 0342, USA
    Arch Otolaryngol Head Neck Surg 135:73-9. 2009
    ..To review of the natural history of airway disease in children with muccopolysaccharidoses (MPSs), which represent a group of hereditary progressive disorders caused by excessive accumulation of glycosaminoglycans in various tissues...
  9. pmc Upper airways abnormalities and tracheal problems in Morquio's disease
    P P Walker
    Department of Respiratory Medicine, University Hospital Aintree, Liverpool, UK
    Thorax 58:458-9. 2003
    ..With advances in home ventilation, these patients are increasingly likely to be referred to specialist respiratory units. We describe our experiences with two such patients...
  10. pmc Relationship between peripheral airway dysfunction, airway obstruction, and neutrophilic inflammation in COPD
    R A O'Donnell
    Respiratory Cell and Molecular Biology, Division of Infection, Inflammation and Repair, University of Southampton, Southampton General Hospital, Southampton SO16 6YD, UK
    Thorax 59:837-42. 2004
    ..A number of research tools have been combined to study smokers with a range of COPD severities classified according to the GOLD criteria...
  11. ncbi Tracheobronchomalacia and excessive dynamic airway collapse
    Septimiu D Murgu
    Pulmonary and Critical Care Medicine, Department of Medicine, University of California School of Medicine, Irvine, CA, USA
    Respirology 11:388-406. 2006
    Tracheobronchomalacia and excessive dynamic airway collapse are two separate forms of dynamic central airway obstruction that may or may not coexist. These entities are increasingly recognized as asthma and COPD imitators...
  12. pmc Airway count and emphysema assessed by chest CT imaging predicts clinical outcome in smokers
    Alejandro A Diaz
    Pulmonary and Critical Care Medicine Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Chest 138:880-7. 2010
    ....
  13. doi Should FEV1/FEV6 replace FEV1/FVC ratio to detect airway obstruction? A metaanalysis
    Ji yong Jing
    Respiratory Department, Second Affiliated Hospital, School of Medicine, Zhejiang University, Jiefang Road 88, Hangzhou, Zhejiang Province, People s Republic of China
    Chest 135:991-8. 2009
    The conventional FEV(1)/FVC test is the "gold standard" to quantitate airway obstruction, but elderly subjects or patients with severe respiratory diseases quite frequently cannot make such an effort...
  14. pmc Percent emphysema, airflow obstruction, and impaired left ventricular filling
    R Graham Barr
    Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    N Engl J Med 362:217-27. 2010
    ....
  15. ncbi Concentration of matrix metalloproteinase-9 in serum of patients with chronic obstructive pulmonary disease and a degree of airway obstruction and disease progression
    B Brajer
    Department of Pulmonary Diseases, Poznan University of Medical Sciences, Poznan, Poland
    J Physiol Pharmacol 59:145-52. 2008
    Chronic obstructive pulmonary disease (COPD) is chronic inflammation leading to irreversible airway obstruction. Previous studies showed increased metalloproteinases (MMP) level, especially MMP-9, as a sign of local inflammation...
  16. ncbi Association of dietary antioxidants and waist circumference with pulmonary function and airway obstruction
    R Chen
    Cardiovascular Epidemiology Unit, University of Dundee, Ninewells Hospital and Medical School, Scotland, United Kingdom
    Am J Epidemiol 153:157-63. 2001
    ..A case-control study of airway obstruction showed that waist circumference was significantly associated, while vitamin C could be protective...
  17. pmc CT metrics of airway disease and emphysema in severe COPD
    Woo Jin Kim
    Department of Internal Medicine, Kangwon National University, Chuncheon, South Korea
    Chest 136:396-404. 2009
    ..The contribution of CT scan-assessed airway disease to objective measures of lung function and respiratory symptoms such as dyspnea in severe emphysema is less clear...
  18. doi Risk factors associated with irreversible airflow limitation in asthma
    Anneke ten Brinke
    Department of Pulmonology, Medical Center Leeuwarden, Leeuwarden, The Netherlands
    Curr Opin Allergy Clin Immunol 8:63-9. 2008
    ..This paper reviews recent literature on natural course, risk factors, and potential mechanisms of persistent airflow limitation in asthma...
  19. ncbi Fast onset of effect of budesonide/formoterol versus salmeterol/fluticasone and salbutamol in patients with chronic obstructive pulmonary disease and reversible airway obstruction
    Anne Lindberg
    Department of Respiratory Medicine, Sunderby Central Hospital of Norrbotten, Lulea, Sweden
    Respirology 12:732-9. 2007
    Data on the onset of action of COPD medications are lacking. This study compared the onset of bronchodilation following different inhaled therapies in patients with moderate-to-severe COPD and reversible airway obstruction.
  20. ncbi Cine magnetic resonance imaging: evaluation of persistent airway obstruction after tonsil and adenoidectomy in children with Down syndrome
    Sally R Shott
    Department of Otolaryngology Head and Neck Surgery, University of Cincinnati Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, U S A
    Laryngoscope 114:1724-9. 2004
    ..The cine magnetic resonance image (MRI) is useful in evaluating the upper airway in those patients who have not achieved a normal polysomnogram after T&A surgery...
  21. pmc IL-13-producing BLT1-positive CD8 cells are increased in asthma and are associated with airway obstruction
    A Dakhama
    Department of Pediatrics, National Jewish Health, Denver, CO 80014, USA
    Allergy 68:666-73. 2013
    ..We investigated whether a subset of IL-13-producing BLT1-positive CD8 T lymphocytes are present in asthmatic airways and are associated with impaired lung function...
  22. doi Comparison of the lower confidence limit to the fixed-percentage method for assessing airway obstruction in routine clinical practice
    Ashutosh N Aggarwal
    Department of Pulmonary Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, India
    Respir Care 56:1778-84. 2011
    ..70) for diagnosing airway obstruction, the fixed-cutoff method continues to be used and advocated.
  23. ncbi Otorhinolaryngological manifestations of the mucopolysaccharidoses
    M A Simmons
    Department of Otorhinolaryngology, The Royal Manchester Childrens Hospital Pendlebury, Manchester, UK
    Int J Pediatr Otorhinolaryngol 69:589-95. 2005
    ..In this review, we present an overview of the clinical manifestations of MPS in general and highlight the problems specifically presenting in the field of otorhinolaryngology...
  24. pmc Attenuation of early airway obstruction by mesenchymal stem cells in a murine model of heterotopic tracheal transplantation
    Daniel A Grove
    Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia, USA
    J Heart Lung Transplant 30:341-50. 2011
    ..We hypothesized that the injection of MSC would prevent development of early airway obstruction (AO) in the heterotopic tracheal transplant model.
  25. doi The European Respiratory Society spirometry tent: a unique form of screening for airway obstruction
    Sara Maio
    Pulmonary Environmental Epidemiology Unit, CNR Institute of Clinical Physiology, Pisa, Italy
    Eur Respir J 39:1458-67. 2012
    In order to raise public awareness of the importance of early detection of airway obstruction and to enable many people who had not been tested previously to have their lung function measured, the European Lung Foundation and the European ..
  26. ncbi Special airway concerns in patients with mucopolysaccharidoses
    H Steven Sims
    Chicago Institute for Voice Care, University of Illinois at Chicago, IL 60612, USA
    Respir Med 101:1779-82. 2007
    ..Though lifespan is increasing, onset of respiratory pathology or involvement remains portentous. We present two cases that punctuate the need for insightful decision making while managing the airway for these patients...
  27. ncbi Mandibular distraction in neonates: a strategy to avoid tracheostomy
    Arlen Denny
    Medical College of Wisconsin, 9000 West Wisconsin Avenue, Milwaukee, WI 53226, USA
    Plast Reconstr Surg 109:896-904; discussion 905-6. 2002
    ..Findings included retrognathia, glossoptosis, incomplete cleft palate, and airway obstruction in each patient. Birth weights ranged from 2.8 to 3.2 kg...
  28. ncbi Airway stenting: Applications and practice management considerations
    Mark E Lund
    Interventional Pulmonology, Beth Israel Deaconess Medical Center, Harvard Medical School, One Deaconess Rd, Boston, MA 02215, USA
    Chest 131:579-87. 2007
    ..We review the indications for airway stenting, and how the requirement of combined therapies and technical aspects of central airway stenting pertain to practice management...
  29. doi Diagnosis and management of respiratory involvement in Hunter syndrome
    Wolfgang Kamin
    Pediatric Pneumology, Allergy, Endoscopy and Cystic Fibrosis Center, Children s Hospital, University of Mainz, Mainz, Germany
    Acta Paediatr Suppl 97:57-60. 2008
    ..Consequently, such procedures should be performed by an anaesthetist - ideally accompanied by a paediatric pneumologist/intensivist - with experience in managing patients with Hunter syndrome...
  30. doi Clara cell secretory protein is reduced in equine recurrent airway obstruction
    P Katavolos
    Department of Pathobiology, University of Guelph, Guelph, ON, N1G 2W1, Canada
    Vet Pathol 46:604-13. 2009
    Horses are prone to recurrent airway obstruction (RAO), an inflammatory lung disease induced by repeated exposure to environmental mold, dust, and bacterial components...
  31. ncbi Lung perfusion impairments in pulmonary embolic and airway obstruction with noncontrast MR imaging
    Kazuyoshi Suga
    Department of Radiology, Yamaguchi University School of Medicine, Ube, Yamaguchi 755 8505, Japan
    J Appl Physiol (1985) 92:2439-51. 2002
    ..resonance imaging was applied to noninvasively define perfusion impairments in pulmonary embolic and airway obstruction dog models...
  32. ncbi Periodontitis and airway obstruction
    James A Katancik
    Department of Periodontology, University of Tennessee, Memphis, TN 38163, USA
    J Periodontol 76:2161-7. 2005
    The objective of this study was to examine the relationship between airway obstruction and periodontal disease.
  33. ncbi Floor of mouth haemorrhage and life-threatening airway obstruction during immediate implant placement in the anterior mandible
    B M Woo
    Oregon Health and Science University, Department of Oral and Maxillofacial Surgery, Portland, OR 97239 3097, USA
    Int J Oral Maxillofac Surg 35:961-4. 2006
    ..In the following report, the authors will describe a life-threatening complication that resulted from the placement of mandibular implants...
  34. ncbi New technique for airway correction in neonates with severe Pierre Robin sequence
    Arlen Denny
    Department of Plastic Surgery, Medical College of Wisconsin, Children s Hospital of Wisconsin, Milwaukee, WI 53225, USA
    J Pediatr 147:97-101. 2005
    ..We conclude that distraction osteogenesis to increase the length of the short mandible is an effective alternative to tracheostomy in carefully selected patients...
  35. ncbi Correction of upper airway obstruction in the newborn with internal mandibular distraction osteogenesis
    Keyoumars Izadi
    Children s Hospital of Pittsburgh, Division of Plastic and Reconstructive Surgery, University of Pittsburgh, Pennsylvania, USA
    J Craniofac Surg 14:493-9. 2003
    Tracheostomy for management of neonatal airway obstruction may be life saving but is associated with complications and developmental problems...
  36. ncbi [Right main bronchus tumoral obstruction during left pneumonectomy]
    P Markowicz
    Service d Anesthésie, Groupe Hospitalier Sud Reunion, 97400 Saint Pierre, France
    Ann Fr Anesth Reanim 25:648-51. 2006
    We report a case of severe airway obstruction during a pneumonectomy, due to a tumor embolus in the contralateral main bronchus. Trachea was intubated with a single-lumen tube with a bronchial blocker...
  37. ncbi Anterior cervical screw extrusion leading to acute upper airway obstruction: case report
    David T Wong
    Division of Neurosurgery, Department of Anesthesiology, University of Toronto, Ontario, Canada
    Spine (Phila Pa 1976) 30:E683-6. 2005
    ..Case report of late postoperative complication...
  38. doi Outcomes of airway stenting for advanced lung cancer with central airway obstruction
    Hisashi Saji
    Department of Thoracic Surgery and Oncology, Tokyo Medical University, 6 7 1, Nishishinjuku, Shinjuku ku, Tokyo 160 0023, Japan
    Interact Cardiovasc Thorac Surg 11:425-8. 2010
    Approximately 30% of lung cancer patients will develop central airway obstruction (CAO)...
  39. ncbi Comparison of effects of dexamethasone and the leukotriene D4 receptor antagonist L-708,738 on lung function and airway cytologic findings in horses with recurrent airway obstruction
    Jean Pierre Lavoie
    Department of Clinical Sciences, Faculte de Medecine Veterinaire, Universite de Montreal, St Hyacinthe, QC, Canada
    Am J Vet Res 63:579-85. 2002
    To evaluate whether the leukotriene (LT) D4 receptor antagonist L-708,738 is therapeutically beneficial in treating horses with recurrent airway obstruction (heaves).
  40. ncbi Rigid bronchoscopic intervention in patients with respiratory failure caused by malignant central airway obstruction
    Kyeongman Jeon
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
    J Thorac Oncol 1:319-23. 2006
    Bronchoscopic intervention in patients with malignant central airway obstruction provides initial palliation and stabilization of the airway, allowing the possibility of other effective therapeutic modalities, such as surgery, radiation, ..
  41. doi Percutaneous fetoscopic laser decompression of congenital high airway obstruction syndrome (CHAOS) from laryngeal atresia via a single trocar--current technical constraints and potential solutions for future interventions
    Thomas Kohl
    Department of Obstetrics and Prenatal Medicine, German Center for Fetal Surgery and Minimally Invasive Therapy, Bonn, Germany
    Fetal Diagn Ther 25:67-71. 2009
    To alleviate congenital high airway obstruction syndrome (CHAOS) from laryngeal atresia by percutaneous minimally-invasive fetoscopic tracheal decompression using laser.
  42. doi Airway obstruction and gas leak during mask ventilation of preterm infants in the delivery room
    Georg M Schmölzer
    Neonatal Services, The Royal Women s Hospital, Melbourne, Australia
    Arch Dis Child Fetal Neonatal Ed 96:F254-7. 2011
    ..The authors examined recordings of PPV given to preterm infants in the delivery room for prevalence of mask leak and airway obstruction.
  43. ncbi Prevalence and reversibility of lower airway obstruction in children with sickle cell disease
    A C Koumbourlis
    Division of Pediatric Pulmonology, College of Physicians and Surgeons of Columbia University and Babies and Children s Hospital of New York, New York, New York 10032, USA
    J Pediatr 138:188-92. 2001
    OBJECTIVE: To determine the prevalence and reversibility of lower airway obstruction (LAO) in children and adolescents with hemoglobin SS sickle cell disease (HbSS SCD)...
  44. pmc Airway obstruction is increased in pneumocystis-colonized human immunodeficiency virus-infected outpatients
    Alison Morris
    University of Pittsburgh Medical Center, 628 NW MUH, 3459 Fifth Avenue, Pittsburgh, PA 15213, USA
    J Clin Microbiol 47:3773-6. 2009
    We investigated the relationship of Pneumocystis colonization, matrix metalloprotease levels in sputum, and airway obstruction in a cohort of human immunodeficiency virus (HIV)-infected outpatients...
  45. doi Evaluation of MUC5AC expression and upregulation in airway epithelial cells of horses
    Karen L Oslund
    Department of Pathology, Microbiology, and Immunology, School of Veterinary Medicine and Center for Comparative Respiratory Biology and Medicine, School of Medicine, University of California Davis, Davis, CA 95616, USA
    Am J Vet Res 71:690-6. 2010
    ..To isolate and culture primary equine airway epithelial cells in vitro and elucidate the major cytokines involved in expression of the gel-forming mucin gene MUC5AC in horses...
  46. ncbi Cryorecanalization: a new approach for the immediate management of acute airway obstruction
    Martin Hetzel
    Department of Internal Medicine II Pulmonary Medicine, University Medical Center Ulm, Ulm, Germany
    J Thorac Cardiovasc Surg 127:1427-31. 2004
    ..In this study we demonstrate a newly developed cryoprobe allowing recanalization of tumor stenoses during a single intervention...
  47. ncbi Heterotopic neuroglial tissue causing airway obstruction in the newborn
    P M Behar
    Department of Pediatric Otolaryngology, The Children s Hospital of Buffalo, 219 Bryant St, Buffalo, NY 14222, USA
    Arch Otolaryngol Head Neck Surg 127:997-1002. 2001
    Heterotopic neuroglial (brain) tissue is a rare cause of airway obstruction in newborns. Fewer than 30 cases have been reported in the English literature. Brain heterotopias can mimic more common congenital anomalies of the head and neck.
  48. doi In vivo monitoring of cystic fibrosis-like lung disease in mice by volumetric computed tomography
    M O Wielpütz
    Dept of Radiology, German Cancer Research Center, Heidelberg, Germany
    Eur Respir J 38:1060-70. 2011
    ....
  49. ncbi Self-expandable metallic airway stents and flexible bronchoscopy: long-term outcomes analysis
    Cynthia P Saad
    Division of Pulmonary and Critical Care Medicine, The Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Chest 124:1993-9. 2003
    ..s: To report and analyze our 6-year experience with implanting 112 self-expandable metallic stents (SEMSs) using flexible bronchoscopy (FB)...
  50. ncbi FEV1/FEV6 and FEV6 as an alternative for FEV1/FVC and FVC in the spirometric detection of airway obstruction and restriction
    Jan Vandevoorde
    Department of General Practice, Dutch Speaking University of Brussels Vrije Universiteit Brussel, Brussels, Belgium
    Chest 127:1560-4. 2005
    To evaluate the use of the FEV(1)/forced expiratory volume at 6 s of exhalation (FEV(6)) ratio and FEV(6) as an alternative for FEV(1)/FVC and FVC in the detection of airway obstruction and lung restriction, respectively.
  51. ncbi Central airway obstruction
    Armin Ernst
    Pulmonology and Critical Care Division, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Am J Respir Crit Care Med 169:1278-97. 2004
    Central airway obstruction is a problem facing all medical and surgical subspecialists caring for patients with chest diseases...
  52. ncbi Efficacy of the FEV1/FEV6 ratio compared to the FEV1/FVC ratio for the diagnosis of airway obstruction in subjects aged 40 years or over
    F W Rosa
    Disciplina de Pneumologia e Centro de Reabilitação Pulmonar, Escola Paulista de Medicina, Universidade Federal de Sao Paulo, Sao Paulo, SP, Brasil
    Braz J Med Biol Res 40:1615-21. 2007
    ..between the sensitivity and specificity of the FEV1/FEV6 ratio compared to two FEV1/FVC cut-off points for airway obstruction: equal to 70 (area under the curve = 0.98, P < 0.0001) and the LLN (area under the curve = 0.97, P < 0...
  53. ncbi Fetoscopic and ultrasound-guided decompression of the fetal trachea in a human fetus with Fraser syndrome and congenital high airway obstruction syndrome (CHAOS) from laryngeal atresia
    T Kohl
    German Center for Fetal Surgery and Minimally Invasive Therapy, Department of Obstetrics and Prenatal Medicine, University of Bonn, Bonn, Germany
    Ultrasound Obstet Gynecol 27:84-8; discussion 88. 2006
    Congenital high airway obstruction syndrome (CHAOS) from laryngeal atresia bears a poor prognosis for hydropic fetuses owing to cardiac failure...
  54. pmc Risk factors associated with the presence of irreversible airflow limitation and reduced transfer coefficient in patients with asthma after 26 years of follow up
    J M Vonk
    Department of Epidemiology and Statistics, University of Groningen, The Netherlands
    Thorax 58:322-7. 2003
    Childhood asthma is generally believed to be a disorder with a good prognosis. However, some asthmatics develop irreversible airway obstruction, probably as a result of airway remodelling.
  55. ncbi A clinically silent respiratory infection with Chlamydophila spp. in calves is associated with airway obstruction and pulmonary inflammation
    Julia Jaeger
    Institute of Molecular Pathogenesis in the Friedrich Loeffler Institute Federal Research Institute for Animal Health, Naumburger Str 96a, 07743 Jena, Germany
    Vet Res 38:711-28. 2007
    ..animals was distinguished by significantly higher peripheral airway resistance (indicating peripheral airway obstruction), significantly higher respiratory rates, and significantly higher minute volumes of ventilation...
  56. ncbi FVC to slow inspiratory vital capacity ratio: a potential marker for small airways obstruction
    Judith Cohen
    Department of Pulmonology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Chest 132:1198-203. 2007
    ....
  57. doi Challenges and advances in intubation: rapid sequence intubation
    Sharon Elizabeth Mace
    Cleveland Clinic Lerner College of Medicine of Case Western Reserve, Cleveland, OH 44195, USA
    Emerg Med Clin North Am 26:1043-68, x. 2008
    ..Controversy has arisen regarding various steps in RSI; however, RSI remains the standard of care in emergency medicine airway management...
  58. ncbi Stenting at the flow-limiting segment in tracheobronchial stenosis due to lung cancer
    Teruomi Miyazawa
    Department of Pulmonary Medicine, Hiroshima City Hospital, 7 33 Naka Ku, Moto machi, Hiroshima, Japan 730 8518
    Am J Respir Crit Care Med 169:1096-102. 2004
    ..01). Stenting at the choke point improved expiratory flow limitation by increasing the cross-sectional area, supporting the weakened airway wall and relieving dyspnea...
  59. ncbi Complications of tracheotomy in patients with mucopolysaccharidoses type II (Hunter syndrome)
    Han Sin Jeong
    Department of Otorhinolaryngology Head and Neck Surgery, Sungkyunkwan University School of Medicine, Samsung Medical Center, 50 Irwon dong, Gangnam Gu, Seoul 135 710, Republic of Korea
    Int J Pediatr Otorhinolaryngol 70:1765-9. 2006
    ..To investigate the complication rate of tracheotomy in patients with mucopolysacchridoses (MPS) type II (Hunter syndrome)...
  60. ncbi Children with mucopolysaccharidosis: perioperative care, morbidity, mortality, and new findings
    K G Belani
    Department of Anesthesiology, University of Minnesota, Minneapolis
    J Pediatr Surg 28:403-8; discussion 408-10. 1993
    ..05). A total of 28 children underwent bone marrow transplantation (BMT); this reversed upper airway obstruction and also reversed intracranial hypertension...
  61. pmc α₁-Antitrypsin protease inhibitor MZ heterozygosity is associated with airflow obstruction in two large cohorts
    Inga Cecilie Sørheim
    Channing Laboratory, Brigham and Women s Hospital and Harvard Medical School, 181 Longwood Ave, Boston, MA 02115, USA
    Chest 138:1125-32. 2010
    ..Heterozygous (protease inhibitor [PI] MZ) individuals have moderately reduced serum levels of α₁-antitrypsin, but whether they have an increased risk of COPD is uncertain...
  62. ncbi Airway obstruction in children with congenital heart disease: assessment by flexible bronchoscopy
    S L Lee
    Department of Paediatrics, Queen Mary Hospital, Hong Kong, People s Republic of China
    Pediatr Pulmonol 34:304-11. 2002
    ..imaging results of pediatric cardiac patients who presented with either clinical or radiological signs of airway obstruction between 1992-1999 were reviewed...
  63. ncbi The association between small airway obstruction and emphysema phenotypes in COPD
    Won Dong Kim
    Division of Pulmonary and Critical Care Medicine, Asan Medical Center, University of Ulsan College of Medicine, 388 1 Pungnap dong, Songpa Gu, Seoul 138 736, Republic of Korea
    Chest 131:1372-8. 2007
    Airflow limitation in COPD is due to a variable combination of small airway obstruction and centrilobular emphysema (CLE) and/or panlobular emphysema (PLE), but the relationship between these three different phenotypes is poorly ..
  64. ncbi Comparison of FEV6 and FVC for detection of airway obstruction in a community hospital pulmonary function laboratory
    Shelagh Gleeson
    Pulmonary Division, Department Medicine, Norwalk Hospital, 40 prospect Aveune, Bldg1, Apt 1G, Norwalk, CT 06850, USA
    Respir Med 100:1397-401. 2006
    ..However, its moderate specificity may hinder its utility as a screening test. Further testing is necessary to determine its reliability in different patient populations with less highly trained operators...
  65. ncbi Respiratory impedance response to a deep inhalation in asthmatic children with spontaneous airway obstruction
    C Schweitzer
    Laboratoire d Explorations Fonctionnelles Pédiatriques, Hĵpital d Enfants, Centre Hospitalier Universitaire de Nancy, Vandoeuvre, France
    Eur Respir J 19:1020-5. 2002
    ..of a deep inhalation (DI) may be detected during tidal breathing in asthmatic children with spontaneous airway obstruction (AO). Two groups of children aged 5-15 yrs were studied...
  66. ncbi Airway obstruction in children aged less than 5 years: the prehospital experience
    Gary M Vilke
    San Diego County Division of Emergency Medical Services, San Diego, California, USA
    Prehosp Emerg Care 8:196-9. 2004
    ..Treatment of choking in children has been well studied, but few data are available on the various causes of the choking episodes in the pediatric population...
  67. doi Effect of hay dust extract and cyathostomin antigen stimulation on cytokine expression by PBMC in horses with recurrent airway obstruction
    Simone Lanz
    Swiss Institute of Equine Medicine, University of Bern and ALP Haras, Switzerland Electronic address
    Vet Immunol Immunopathol 155:229-37. 2013
    Equine recurrent airway obstruction (RAO) is an inflammatory, obstructive airway disease induced by exposure of susceptible horses to inhaled organic dust particles. The immunological process underlying RAO is still unclear...
  68. ncbi Evaluation of airway obstruction by nasopharyngoscopy: comparison of the Müller maneuver versus induced sleep
    Marcelo Gervilla Gregório
    Respiratory Endoscopy Service, University of Sao Paulo Medical School
    Braz J Otorhinolaryngol 73:618-22. 2007
    ..of intrathoracic pressure (Müller maneuver) is frequently employed to establish the site of upper airway obstruction. The Müller maneuver, however, is used when the patient is awake and therefore may not correlate with ..
  69. doi Underestimation of airflow obstruction among young adults using FEV1/FVC <70% as a fixed cut-off: a longitudinal evaluation of clinical and functional outcomes
    I Cerveri
    Division of Respiratory Diseases, IRCCS San Matteo Hospital Foundation, University of Pavia, Pavia, Italy
    Thorax 63:1040-5. 2008
    ..The lower limit of normal (LLN), which is statistically defined by the lower fifth percentile of a reference population, is physiologically appropriate but it still needs a clinical validation...
  70. ncbi Chronic upper airway obstruction and cardiac dysfunction: anatomy, pathophysiology and anesthetic implications
    Richard H Blum
    Department of Anesthesia, Perioperative and Pain Medicine, Children s Hospital, Boston and Harvard Medical School, Boston, MA 02115, USA
    Paediatr Anaesth 14:75-83. 2004
    ..breathing can adversely affect craniofacial growth, and abnormal craniofacial development can promote upper airway obstruction. Chronic upper airway obstruction often presents with evidence of obstructive sleep apnea syndrome; in ..
  71. ncbi Laryngocele: a cause of upper airway obstruction
    Jose Antonio de Paula Felix
    Universidade Federal Fluminense, RJ, Brazil
    Braz J Otorhinolaryngol 74:143-6. 2008
    ..Sometimes it is presented as cervical swelling causing airway obstruction in need of emergency intervention...
  72. ncbi Assessment of lateral cephalometric diagnosis of adenoid hypertrophy and posterior upper airway obstruction: a systematic review
    Michael P Major
    Goldman School of Dental Medicine, Boston University, Boston, MA, USA
    Am J Orthod Dentofacial Orthop 130:700-8. 2006
    ..Our objective was to evaluate the capability of lateral cephalograms in diagnosing hypertrophied adenoids and obstructed posterior nasopharyngeal airways...
  73. pmc Small airway obstruction in COPD: new insights based on micro-CT imaging and MRI imaging
    James C Hogg
    James Hogg Research Centre, The University of British Columbia, Vancouver, BC, Canada
    Chest 143:1436-43. 2013
    ..reduction in numbers of terminal bronchioles contribute to the rapid decline in FEV₁ that leads to severe airway obstruction in COPD...
  74. ncbi Relationship between airway obstruction and respiratory symptoms in adult asthmatics
    J G Teeter
    Department of Medicine, University of Maryland School of Medicine, Baltimore 21201, USA
    Chest 113:272-7. 1998
    To characterize the relationship between symptoms and the degree of airway obstruction as determined by the FEV1 and peak expiratory flow (PEF) in a cohort of adult patients attending a university-based urban asthma clinic.
  75. ncbi Airway obstruction by granulation tissue within a fenestrated tracheotomy tube: case report
    Michael A Carron
    Department of Otolaryngology Head and Neck Surgery, 5E UHC, School of Medicine, Wayne State University, 4201 St Antoine, Detroit, MI 48201, USA
    Ear Nose Throat J 85:54-5. 2006
    ..In this case, the granulation tissue grew through the fenestrations, obliterated the tracheal lumen, and tethered the tube to the trachea itself. As a result, the patient required emergency treatment to restore airway patency...
  76. doi Bronchoscopic assessment of airway involvement in children presenting with clinically significant airway obstruction due to tuberculosis
    Pierre Goussard
    Faculty of Health Sciences, Departments of Paediatrics and Child Health, Stellenbosch University, and Tygerberg Children s Hospital, Tygerberg, Cape Town, South Africa
    Pediatr Pulmonol 48:1000-7. 2013
    ..There are few published studies on the bronchoscopic appearance and severity of airway obstruction caused by lymph node involvement of the airways resulting from Mycobacterium tuberculosis (MTB)...
  77. pmc Drug-induced sleep endoscopy vs awake Müller's maneuver in the diagnosis of severe upper airway obstruction
    Danny Soares
    Department of Otolaryngology Head and Neck Surgery, Wayne State University and Karmanos Cancer Institute, Detroit, Michigan 48201, USA
    Otolaryngol Head Neck Surg 148:151-6. 2013
    ....
  78. ncbi Histoplasmosis presenting as upper airway obstruction
    C G Larsen
    Department of Otolaryngology Head and Neck Surgery, University of Kansas Medical Center, Kansas City, KS, USA
    Otolaryngol Head Neck Surg 132:514-6. 2005
  79. ncbi Leukotriene E(4)-induced persistent eosinophilia and airway obstruction are reversed by zafirlukast in patients with asthma
    Annika Laitinen
    Institute of Biomedicine, Department of Anatomy, University of Helsinki, Helsinki, Finland
    J Allergy Clin Immunol 115:259-65. 2005
    ..We have shown that inhalation of leukotriene (LT) E 4 contributes to specific recruitment of eosinophils to the airway mucosa in patients with asthma at the time of maximal decrease in airway-specific conductance...
  80. ncbi Adult foreign body airway obstruction in the prehospital setting
    Arash Soroudi
    County of San Diego, Division of Emergency Medical Services, and Department of Emergency Medicine, University of California, San Diego Medical Center, San Diego, California 92103, USA
    Prehosp Emerg Care 11:25-9. 2007
    Although the treatment of foreign body airway obstruction in adults has been well studied, few data exist on the characterization of prehospital experiences.
  81. pmc Internal laryngopyocele as a cause of acute airway obstruction: an extremely rare case and review of the literature
    I Vasileiadis
    Department of Otolaryngology Head and Neck Surgery, Venizeleio Pananeio Hospital, Herakleion, Greece
    Acta Otorhinolaryngol Ital 32:58-62. 2012
    ..Only in 4 cases was a laryngopyocele reported to have caused acute airway obstruction and only one case of internal laryngopyocele causing acute airway obstruction has been reported until now...
  82. pmc An RGS4-mediated phenotypic switch of bronchial smooth muscle cells promotes fixed airway obstruction in asthma
    Gautam Damera
    Airways Biology Initiative, Pulmonary, Allergy and Critical Care Division, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
    PLoS ONE 7:e28504. 2012
    ..These studies indicate that increased RGS4 expression promotes a phenotypic switch of ASM, evoking irreversible airway obstruction in subjects with severe asthma.
  83. doi Surgical management of laryngeal collapse associated with brachycephalic airway obstruction syndrome in dogs
    R N White
    Willows Veterinary Centre and Referral Service, Highlands Road, Shirley, Solihull, West Midlands B90 4NH
    J Small Anim Pract 53:44-50. 2012
    ..To describe the use of cricoarytenoid lateralisation combined with thyroarytenoid caudo- lateralisation (arytenoid laryngoplasty) for the management of stage II and III laryngeal collapse in dogs...
  84. ncbi Mucositis and airway obstruction in a pediatric patient
    Kathleen H Chaimberg
    Department of Anesthesiology, Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire 03756, USA
    Anesth Analg 99:59-61. 2004
    ..The patient was undergoing induction chemotherapy for stage IV rhabdomyosarcoma and developed severe mucositis that led to progressive airway obstruction.
  85. doi Description of original endoscopic findings and respiratory functional assessment using barometric whole-body plethysmography in dogs suffering from brachycephalic airway obstruction syndrome
    Frederique Bernaerts
    Department for Clinical Sciences B44, Faculty of Veterinary Medicine, University of Liege, 4000 Liege, Belgium
    Vet J 183:95-102. 2010
    ..Following surgery, a significant decrease in PEF/PIF was detected. The study showed that BWBP could be used to characterise the respiratory strategy in brachycephalic dogs before and after surgery...
  86. ncbi Pyriform sinus mucosa stabilization for prevention of postoperative airway obstruction in arytenoid adduction
    Nicolas E Maragos
    Department of Otorhinolaryngology, Mayo Clinic, Rochester, Minnesota, USA
    Ann Otol Rhinol Laryngol 115:171-4. 2006
    The Isshiki arytenoid adduction procedure directly closes the open posterior glottis. Postoperative airway obstruction that necessitates emergent tracheotomy is an important complication in arytenoid adduction patients when the standard ..
  87. doi Increased apoptosis of CD4 and CD8 T lymphocytes in the airways of horses with recurrent airway obstruction
    Gabriel Morán
    Department of Pharmacology, Faculty of Veterinary Science, Universidad Austral de Chile, 567, Valdivia, Chile
    Vet Res Commun 35:447-56. 2011
    Recurrent airway obstruction (RAO, also known as equine heaves) is an inflammatory condition similar to human asthma caused by exposure of susceptible horses to poorly ventilated stable environments...
  88. doi Experimental induction of recurrent airway obstruction with inhaled fungal spores, lipopolysaccharide, and silica microspheres in horses
    Janet Beeler-Marfisi
    Department of Pathobiology, Ontario Veterinary College, University of Guelph, Guelph, ON N1G 2W1, Canada
    Am J Vet Res 71:682-9. 2010
    To evaluate experimental induction of recurrent airway obstruction (RAO) with inhaled fungal spores, lipopolysaccharide, and silica microspheres in horses.
  89. ncbi Impulse oscillometry: a measure for airway obstruction
    Geraldine R Vink
    Department of Paediatric Pulmonology, Wilhelmina Children s Hospital, University Medical Center Utrecht, Utrecht, The Netherlands
    Pediatr Pulmonol 35:214-9. 2003
    ..This might be helpful in patients who are not able to perform forced breathing maneuvers. In individual subjects, R values measured at 5 Hz showed to be superior to PEF measurements in the detection of a 15% fall in FEV(1)...
  90. doi SUDEP, suspected positional airway obstruction, and hypoventilation in postictal coma
    James X Tao
    Department of Neurology, Adult Epilepsy Center, The University of Chicago, Chicago, IL 60637, USA
    Epilepsia 51:2344-7. 2010
    ..The cause of her death was likely asphyxia from the convergence of postictal coma and suspected positional airway obstruction and hypoventilation, rather than the commonly suspected periictal cardiac arrhythmia or central apnea...
  91. doi Neutrophil and platelet activation in equine recurrent airway obstruction is associated with increased neutrophil CD13 expression, but not platelet CD41/61 and CD62P or neutrophil-platelet aggregate formation
    B Dunkel
    Department of Veterinary Basic Sciences, The Royal Veterinary College, North Mymms, Herts AL9 7TA, UK
    Vet Immunol Immunopathol 131:25-32. 2009
    Recurrent airway obstruction (RAO) in mature horses is characterized by reversible airway obstruction and neutrophilic inflammation; there is also functional activation of circulating platelets and neutrophils...
  92. doi External laryngopyocele: a rare cause of upper airway obstruction
    Cengiz Ozcan
    Department of Otorhinolaryngology, School of Medicine, Mersin University, Turkey
    J Craniofac Surg 21:2022-4. 2010
    ..We report a rare case of an external laryngopyocele that presented as upper airway obstruction. We also discussed the effect of needle aspiration in the emergency treatment of external laryngopyocele.
  93. doi Computed tomographic imaging of dogs with primary laryngeal or tracheal airway obstruction
    Krystina Stadler
    Department of Veterinary Clinical Medicine, University of Illinois at Urbana Champaign, 1008 W Hazelwood Dr, Urbana, Illinois 61802, USA
    Vet Radiol Ultrasound 52:377-84. 2011
    ..examination, endoscopy, video fluoroscopy, and necropsy were used for achieving the cause of the upper airway obstruction. The CT and 3D internal rendering accurately indicated the presence and cause of upper airway obstruction in ..
  94. pmc Smoking, longer disease duration and absence of rhinosinusitis are related to fixed airway obstruction in Koreans with severe asthma: findings from the COREA study
    Taehoon Lee
    Department of Allergy and Clinical Immunology, Asan Medical Center, University of Ulsan College of Medicine, Asanbyeongwon gil 86, Songpa Gu, Seoul, 138 736, Korea
    Respir Res 12:1. 2011
    ..Some individuals with severe asthma develop irreversible fixed airway obstruction, which is associated with poor outcomes...
  95. ncbi Sputum levels of metalloproteinase-9 and tissue inhibitor of metalloproteinase-1, and their ratio correlate with airway obstruction in lung transplant recipients: relation to tumor necrosis factor-alpha and interleukin-10
    K M Beeh
    Pulmonary Department, Internal Medicine, University Hospital, Mainz, Germany
    J Heart Lung Transplant 20:1144-51. 2001
    ..Matrix-metalloproteinases (MMPs) and their inhibitors, the tissue inhibitors of metalloproteinases (TIMPs), are involved in the turnover of extracellular matrix...
  96. ncbi Mandibular distraction osteogenesis in very young patients to correct airway obstruction
    A D Denny
    Medical College of Wisconsin, Milawaukee 53226, USA
    Plast Reconstr Surg 108:302-11. 2001
    ..Airway improvement is independent of the syndrome diagnosed. Mandibular distraction osteogenesis may be useful to avoid or decannulate existing tracheostomy in infants with micrognathia...
  97. pmc Prevalence of airway obstruction assessed by lung function questionnaire
    Matthew L Mintz
    Department of Medicine, George Washington University School of Medicine, Washington, DC, USA
    Mayo Clin Proc 86:375-81. 2011
    ..To estimate the prevalence of unidentified chronic obstructive pulmonary disease (COPD) and determine the screening accuracy of the Lung Function Questionnaire (LFQ)...
  98. doi Measurement of ascorbic acid concentration and glutathione peroxidase activity in biological samples collected from horses with recurrent airway obstruction
    Rachel H H Tan
    Department of Veterinary Clinical Sciences, School of Veterinary and Biomedical Sciences, James Cook University, Townsville, Qld 4810, Australia
    Am J Vet Res 71:1500-7. 2010
    ..in cells from BALF to determine whether differences existed between the 2 major redox systems in recurrent airway obstruction (RAO)-affected and -nonaffected (control) horses and between systemic and local pulmonary responses in the ..
  99. doi Role of emphysema and airway obstruction in prognosis of lung cancer
    J A Gullón
    Pneumology Service, Hospital Universitario de Canarias, La Laguna, Santa Cruz de Tenerife, Spain
    Lung Cancer 71:182-5. 2011
    ..The aim of our study was to analyze the influence of COPD and emphysema in the prognosis of non-small cell lung cancer (NSCLC)...
  100. ncbi Therapeutic bronchoscopy with immediate effect: laser, electrocautery, argon plasma coagulation and stents
    C T Bolliger
    Lung Unit, Tygerberg Academic Hospital and Faculty of Health Sciences, University of Stellenbosch, Cape Town, South Africa
    Eur Respir J 27:1258-71. 2006
    ..In the palliative setting of alleviating central airway obstruction, laser resection, electrocautery, argon plasma coagulation and stenting are techniques that can provide ..
  101. ncbi Esophageal breathing and upper airway obstruction with the ProSeal laryngeal mask
    Archie Brain
    Anesth Analg 94:1669-70. 2002

Research Grants74

  1. ASTHMA AND ALLERGIC DISEASE CENTER
    Thomas A Platts Mills; Fiscal Year: 2010
    ..The overall objective is to understand the effects of obesity, physical activity and allergic sensitization in relation to symptoms of breathlessness and airway obstruction.
  2. ORGANIZATION OF CENTRAL SYMPATHETIC PATHWAYS
    Patrice G Guyenet; Fiscal Year: 2013
    ..Asphyxia also produces arousal from sleep which enables corrective behavior for example in case of airway obstruction. These reflexes are essential for survival because they quickly restore tissue oxygenation...
  3. Lung VITamin D and OmegA-3 TriaL (Lung VITAL)
    Diane R Gold; Fiscal Year: 2013
    ..in reduction of COPD and asthma exacerbations;in reduction in decline of lung function;in improvement of airway obstruction and asthma control;and in reduction of pneumonia in adults...
  4. Resuscitation of smoke inhalation and burn injury with a thioredoxin mimetic
    ANDREW LURIE SALZMAN; Fiscal Year: 2012
    ..lung inflammation and injury, as manifested in lung wet/dry ratio, lymphatic drainage, lipid peroxidation, airway obstruction, histologic scoring, PMN infiltration, ONOO- (3-nitrotyrosine, "3-NT") formation, and poly(ADP-ribose) ("PAR"..
  5. Genetic and Pharmacologic Evaluation of the Role of HIF-1a in asthma
    LAURA ELISE CROTTY ALEXANDER; Fiscal Year: 2013
    ..Asthma is an inflammatory disease characterized by hypertrophy of smooth muscle, airway obstruction, and increased mucous production3...
  6. Repair of Airway Epithelium Following Chlorine Lung Injury
    Gary W Hoyle; Fiscal Year: 2011
    ..cell barrier contributes to other sequelae observed in acute lung injury, including pulmonary edema, airway obstruction, inflammation, and respiratory infections...
  7. HYPOXIA AND CONTROL OF FETAL BREATHING MOVEMENTS
    Brian J Koos; Fiscal Year: 2010
    ..Sleeping infants who experience oxygen deprivation caused by airway obstruction (e.g...
  8. Novel therapeutics for vesicants and toxic inhaled chemicals (U54)
    Carl W White; Fiscal Year: 2013
    ..Endpoints of oxidative stress, inflammation, increased permeability, and, for lungs, airway obstruction, will be evaluated. Agent(s) found effective for CEES/NM would be evaluated in skin injury by SM...
  9. Role of Microbial Translocation in Cardiopulmonary Disease in Children with HIV
    Alison Morris; Fiscal Year: 2013
    ..We find that MT is correlated with pulmonary hypertension on echocardiography, increased airway obstruction, impairment of diffusing capacity for carbon monoxide, and more rapid progression of pulmonary abnormalities...
  10. Statins for Pulmonary and Cardiac Complications of Chronic HIV (The SPARC Trial)
    Stephen R Wisniewski; Fiscal Year: 2013
    ..statin therapy within the past year tended to have better diffusing capacity for carbon monoxide, less airway obstruction, lower pulmonary artery pressures and cardiac strain, lower peripheral cytokines, and decreased sputum ..
  11. Developmental defects in serotonin neurons and the response to O2 and CO2
    George B Richerson; Fiscal Year: 2011
    ..of SIDS, because a defect in CO2 chemoreception could lead to loss of the normal ventilatory response to airway obstruction or rebreathing during sleep...
  12. Developing Nrf2 as a target for treatment of corticosteroid resistance in COPD
    Robert A Wise; Fiscal Year: 2012
    ..Abnormal airway inflammation is thought to contribute to chronic bronchitis, small-airway obstruction and emphysema...
  13. Role of interleukin-17 and iNKT cells in COPD
    ABDALA EL KHAL; Fiscal Year: 2010
    ..S. population. Both patients affected by atopic asthma and patients with COPD develop airway obstruction. Unlike asthma airway obstruction in patient affected by COPD is progressive and mostly irreversible...
  14. Sleep Disordered Breathing and Growth in Children: A Longitudinal Cohort Study
    Karen Bonuck; Fiscal Year: 2009
    ..Neither they, nor sub-specialists in pediatric GF routinely include upper airway obstruction in their differential diagnosis of GF...
  15. Modulation of Genes Responsible for Cilia Length by Exposure to Cigarette Smoke
    Ann E Tilley; Fiscal Year: 2013
    ..in mucociliary clearance leads to mucus plugging, forming a nidus for infection and eventually worsening airway obstruction. We have observed that clinically healthy smokers, who have no signs or symptoms of lung disease and who ..
  16. Neurotrophin-Secreting Muscle Stem Cell Therapy for Laryngeal Paralysis
    Stacey L Halum; Fiscal Year: 2013
    ..unilateral VFP can cause severe dysphonia and dysphagia, bilateral VFP often causes dysphonia with glottic airway obstruction. Current treatments for VFP are suboptimal in that they fail to restore dynamic motion...
  17. CHRONIC INTERMITTENT HYPOXIA, NEUROVASCULAR DYSFUNCTION AND STROKE
    Costantino Iadecola; Fiscal Year: 2013
    ..SA), is characterized by cyclical interruption of breathing during sleep, often caused by intermittent airway obstruction. SA is emerging as a highly prevalent cause of death and disability...
  18. 1st Tier Drugs+Theophylline in Pediatric Severe Asthma
    JERRY JOHN ZIMMERMAN; Fiscal Year: 2010
    ..saturation, and respiratory rate, and accelerated improvement in spirometry variables associated with small airway obstruction. Previous data from Seattle Children's Hospital indicates the safety and economic benefit of avoiding ..
  19. Exploiting Protease-Activatable Agents to Characterize and Treat Asthma
    Csilla Felsen; Fiscal Year: 2013
    ..by inflammation;accumulation of mast cells, eosinophils, and neutrophils;and intermittent, reversible airway obstruction that affects more than 300 million people worldwide...
  20. The Epidemiology of Home Allergens and Asthma
    Diane R Gold; Fiscal Year: 2010
    ..The relationship of endotoxin to wheeze, asthma and the secondary phenotypes of airway obstruction and airway inflammation, will be dependent on dose, timing, persistence of exposure, and host factors...
  21. Countermeasures for chlorine-induced airway fibrosis
    Gary W Hoyle; Fiscal Year: 2013
    ..We have developed a mouse chlorine inhalation model in which animals develop pulmonary edema, inflammation, airway obstruction, and airway hyperreactivity within one day after exposure...
  22. PHASE II TRIAL OF SLEEP APNEA TREATMENT TO REDUCE CARDIOVASCULAR MORBIDITY
    SUSAN S REDLINE; Fiscal Year: 2010
    ..Despite the availability of positive airway pressure (PAP) therapy, which effectively relieves airway obstruction, most OSA patients remain untreated, and thus at increased CVD risk...
  23. Manipulating Macrophage Phenotype in Laryngeal Nerve Repair
    Jonathan Cheetham; Fiscal Year: 2013
    ..Bilateral injury to the RLN can result in potentially life- threatening airway obstruction and the need for tracheostomy...
  24. Molecular and Genetic Regulation of Craniofacial Development
    Brian L Black; Fiscal Year: 2013
    ..small lower jaw, improperly positioned tongue and posterior cleft of the palate, which can result in upper airway obstruction and feeding difficulties...
  25. The Role of Mfge8 and Apoptotic Cell Clearance in Regulating Asthma Severity
    Kamran Atabai; Fiscal Year: 2010
    ..mediated disease characterized by an overactive immune response to antigens, inflammation and airway obstruction. The incidence of asthma is increasing globally...
  26. Quantification of the State-Dependent Inputs to Hypoglossal Motoneurons
    VICTOR BORISOVICH FENIK; Fiscal Year: 2010
    ..It is caused by partial or complete airway obstruction in individuals with anatomically compromised airways due to a decrease in upper airway muscle (including ..
  27. TSG-6: Novel Regulator of Viral-Induced Hyaluronan Synthesis in Inflamed Airways
    Mark E Lauer; Fiscal Year: 2013
    ..airway hyper-responsiveness to various stimuli, including allergens, pollutants and viruses, resulting in airway obstruction that leads to recurrent episodes of wheezing and coughing...
  28. Airway Inflammatory Pathways Regulating Glucocorticoid Receptor Phosphorylation
    Omar Tliba; Fiscal Year: 2013
    ..provided by applicant): Because airway smooth muscle (ASM) plays a crucial role in driving the excessive airway obstruction and inflammation seen in severe asthma, failure of ASM to properly respond to drug therapy entails serious ..
  29. The effect of HIV on apoptosis and cellular proliferation in laryngeal papillomas
    Michael P Underbrink; Fiscal Year: 2013
    ..cell interactions, specifically of the cellular processes contributing to vocal cord dysfunction and upper airway obstruction caused by human papillomavirus (HPV) infections that lead to recurrent respiratory papillomatosis (RRP)...
  30. Role of the Respiratory Syncytial Virus Fusion Protein in Airway Mucus Induction
    MARTIN LAWRENCE MOORE; Fiscal Year: 2013
    ..Mucus production is a hallmark feature of RSV disease, leading to airway obstruction, hypoxia, and mechanical ventilation...
  31. Alpha-1 AD Carriers and Lung Cancer Risk
    Ping Yang; Fiscal Year: 2009
    ..of smoking cessation among heavy smokers;3) estimate host effects of emphysema +/- chronic bronchitis or airway obstruction on the results obtained from aims 1-2;and 4) explore the effects of selected genes representing inflammation ..
  32. Targeted Therapies for Selected Phenotypes of Obstructive Sleep Apnea
    Jerome A Dempsey; Fiscal Year: 2010
    ..As we reported previously, periodic breathing and central apnea often lead to cyclical airway obstruction at the nadir of the respiratory drive in subjects with more collapsible upper airways...
  33. HA in fungal allergic asthma
    Jane M Schuh; Fiscal Year: 2013
    ..S., is characterized by acute inflammatory exacerbations punctuating a persistent disease. Airway obstruction due to allergic inflammation is largely reversible;however, the cycle of damage and repair that typifies ..
  34. Computer Modeling of Surgical Outcomes for Nasal Airway Obstruction
    John S Rhee; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Nasal airway obstruction (NAO) is a common health condition that is treated by many specialties of medicine and often needs surgical correction...
  35. Genetic analysis of loci associated with naive airway hyperresponsiveness
    EMILY NONE COZZI; Fiscal Year: 2010
    ..is an episodic airway disease characterized by chronic airway inflammation, mucus hypersecretion, reversible airway obstruction, and airway hyperresponsiveness (AHR)...
  36. An Integrated Approach to Airway Epithelial Repair and Regeneration
    Barry R Stripp; Fiscal Year: 2013
    ..pathologic remodeling seen in many lung disorders and contribute to chronic inflammation, fibrosis and airway obstruction. The overarching rationale of this proposal is that novel therapeutic strategies to prevent or reverse ..
  37. Breath controlled Computer Game Controller for Asthma Therapy
    Peter Bingham; Fiscal Year: 2010
    ..The volatility of respiratory symptoms due to asthma is related in large measure to the dynamic nature of airway obstruction in this disease...
  38. HIV and COPD:Immune mediated mechanisms
    Benjamin D Medoff; Fiscal Year: 2013
    ..Using a cohort of patients with chronic HIV infection, we will identify subjects with airway obstruction and compare them to subjects with normal lung function...
  39. Longitudinal Analysis of Transcriptomic Endophenotypes in Asthma
    Geoffrey L Chupp; Fiscal Year: 2013
    ..TEA cluster 1 has a low level of airway inflammation and the most reversible airway obstruction;TEA cluster 2 has a moderate amount of airway inflammation, reversible airflow obstruction, and high sputum ..
  40. Role of Squamous Metaplasia in Small Airways Disease in COPD
    Stephen L Nishimura; Fiscal Year: 2010
    ..suggest that integrin-mediated TGF-[unreadable] activation in airway cell types correlates with worsening airway obstruction. This data suggests that integrins might be novel therapeutic targets in COPD...
  41. Role of WRN Protein in Cigarette Smoke-Induced Cellular Senescence and Emphysema.
    Toru Nyunoya; Fiscal Year: 2011
    DESCRIPTION (provided by applicant): Aging contributes to lung emphysema and progressive airway obstruction due to decreased elastic recoil...
  42. GSK3-beta Signaling in Medullary Thyroid Cancer
    Herbert Chen; Fiscal Year: 2013
    ..is no effective alternative to treat many of the debilitating symptoms associated with incurable MTC such as airway obstruction, flushing, abdominal pain and diarrhea...
  43. Mechanisms of beta-blocker induced improvements in asthma
    Julia K L Walker; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Asthma is characterized by reversible airway obstruction, airway hyperresponsiveness (AHR) and airway inflammation...
  44. The Role of STAT3 in Allergic Inflammation and Airway Remodeling
    Amy Simon; Fiscal Year: 2009
    ..by mucus hypersecretion, airway hyperresponsiveness, and airway wall remodeling that results in variable airway obstruction in genetically susceptible individuals...
  45. Using signatures of T-helper cell inflammation to phenotype human asthma
    NIRAV RATI BHAKTA; Fiscal Year: 2011
    ..provided by applicant): Asthma is a common disease characterized by airway inflammation, reversible airway obstruction, and airway hyperresponsiveness...
  46. Developing Novel Methods to Elucidate Mechanisms of Pediatric Sleep Apnea
    Brian M McGinley; Fiscal Year: 2013
    ..Upper airway obstruction during sleep is the result of deficits in pharyngeal structural properties and/or compensatory neuromuscular...
  47. A Rodent Model of Compromised Upper Airway
    LESZEK K KUBIN; Fiscal Year: 2010
    ..airway lumen to collapse under the centripetal force of the negative inspiratory pressure, which leads to airway obstruction. OSA subjects adapt to this anatomical vulnerability by generating a higher level of activity in their upper ..
  48. Prevention of Allergic Rhinitis with Topical Immunomodulating Antibodies
    Randall M Goldblum; Fiscal Year: 2011
    ..determine whether nasal instillation of bioengineered, recombinant E58 (rE58) will prevent the acute nasal airway obstruction and other signs of allergic inflammation...
  49. Hyperthermia-augmented epithelial apoptosis and acute lung injury
    Jeffrey D Hasday; Fiscal Year: 2013
    ..loss of epithelium can have devastating consequences, including loss of gas exchange, surfactant synthesis, airway obstruction, and increased susceptibility to secondary infections...
  50. Predictive Modeling for Treatment of Upper Airway Obstruction in Young Children
    Carlton J Zdanski; Fiscal Year: 2013
    ..Multiple levels of airway obstruction encountered in these disorders lead to life threatening difficulties in air exchange, problems with ..
  51. RGS: A Molecular Switch Regulating Irreversible ASM Growth/Contraction in Asthma
    REYNOLD ALEXANDER PANETTIERI; Fiscal Year: 2012
    ..inflammation and reversible bronchoconstriction characterize asthma;however, in severe disease, irreversible airway obstruction and increases in airway smooth muscle (ASM) mass/growth commonly occur...
  52. Broncho-adventitial Drug Delivery: Paclitaxel for Bronchial Carcinoma
    KIRK SEWARD; Fiscal Year: 2013
    ..A partial relief of airway obstruction can have remarkable effects on symptoms and quality of life...
  53. Platelet-Derived Growth Factor, Remodeling and Asthma
    Monica Kraft; Fiscal Year: 2010
    ..asthma is a process of permanent structural changes occurring over time, resulting in a component of fixed airway obstruction that can lead to reduced lung function and reduced responsiveness to medications...
  54. Serologic memory and prevention of Pneumocystis-related COPD in AIDS macaque mode
    Karen A Norris; Fiscal Year: 2011
    ..Pc colonization in HIV+ subjects is associated with worse airway obstruction and anatomic emphysema...
  55. Innate Immunity in Allergic Airway Inflammation of Asthma
    TONY EISSA; Fiscal Year: 2010
    Asthma is a chronic inflammatory syndrome that manifests through airway obstruction and airway hyper-responsiveness. Over the past 30 years evidence has accumulated that asthma has increased in prevalence and severity worldwide...
  56. Why Are Steroids Ineffective at Suppressing RSV Bronchiolitis
    Raymond J Pickles; Fiscal Year: 2013
    ..In hamster distal airways, shedding cells accumulate in the narrow lumens causing acute distal airway obstruction accompanied by exaggerated recruitment of inflammatory cells...
  57. Role of Th2 and non-Th2 Inflammation in Airway Smooth Muscle Remodeling in Asthma
    Prescott G Woodruff; Fiscal Year: 2012
    Excessive accumulation of smooth muscle in the airway (smooth muscle remodeling), may contribute to airway obstruction and disease progression in asthma, and recent studies have identified factors that could contribute to this process...
  58. Efficacy and Safety of Beta-adrenoceptor Inverse Agonist, Nadolol in Mild Asthma
    Nicola A Hanania; Fiscal Year: 2013
    ..Asthma is a chronic inflammatory disease of the airways characterized by the presence of reversible airway obstruction and airway hyperresponsiveness...
  59. LUNG DISEASE IN CHINESE TEXTILE WORKERS
    David C Christiani; Fiscal Year: 2013
    ..decades, controversy continues as to whether emphysema or chronic bronchitis is the basis of the observed airway obstruction. Prior autopsy studies on small numbers of deceased workers have been conflicting...
  60. Severity Scale and Quality of Life Instrument for Infantile Hemangiomas
    ANITA NIJHAWAN HAGGSTROM; Fiscal Year: 2010
    ..Complications of hemangiomas include permanent disfigurement, ulceration, bleeding, loss of vision, airway obstruction, congestive heart failure and very rarely death...
  61. Noradrenergic A7 neurons and Upper Airway Motor Control
    VICTOR BORISOVICH FENIK; Fiscal Year: 2013
    ..Due to airway obstruction and repetitive waking during sleep, OSA patients have excessive daytime sleepiness and a diminished quality ..
  62. Immunophenotyping and Lymphocyte Effector Functions in Sarcoidosis
    Laura L Koth; Fiscal Year: 2010
    ..compared to controls, and 3) had higher percentages of CD56+ iNKT cells which correlated with the degree of airway obstruction. We also provide novel data showing IL-17 production by human iNKT cells, supporting the emerging concept ..
  63. Lymphangiogenesis and Angiogenesis in Airway Inflammation
    Donald McDonald; Fiscal Year: 2009
    ..in mucosal lymphatics that impair fluid drainage, and could lead to bronchial lymphedema, which worsens airway obstruction and perturbs immune responses by altering the normal balance of fluid/cell extravasation and clearance...
  64. Nighttime Acoustic Pharyngometer (NAP) for Airway Obstruction Identification
    HANI KAYYALI; Fiscal Year: 2009
    ..We believe NAP will provide the sleep community, for the first time, with an important and convenient complementary tool to help direct surgical or oral appliance treatments for OSA patients. ..
  65. CHEMOSENSITIVITY, UPPER AIRWAY--BREATHING
    Kevin Gleeson; Fiscal Year: 1991
    ..The hyperventilation produced in response to hypoxia or hypercapnia (airway obstruction (sleep apnea) or hypoxic environment (altitude)) may yield hypocapnia and apnea with cycling ventilation...
  66. Photodynamic Therapy for the Treatment of Obstructive E*
    Todd Demmy; Fiscal Year: 2007
    ..by applicant): Endobronchial photodynamic therapy (PDT) is a minimally invasive method of palliating major airway obstruction in patients with advanced lung cancer...
  67. ANIMAL MODELS OF COLD AIR-INDUCED AIRWAY DISEASE
    Michael Davis; Fiscal Year: 2004
    ..Acute airway obstruction in asthmatic humans is common after this stimulus...
  68. IMMUNOCHEMICAL ASSAY OF AEROALLERGENS
    Charles Reed; Fiscal Year: 1991
    ..shown that continued exposure to the allergen after a patient has developed occupational asthma can lead to airway obstruction and hyperresponsiveness that persists for months or years after exposure ceases...
  69. RESPIRATORY SYSTEM INTEGRATION BY THE BRAINSTEM
    ALBERT BERGER; Fiscal Year: 2002
    ..The upper airway is a site of airway obstruction: thus understanding of synaptic transmission to hypoglossal motoneurons (HMs) may provide new insights into ..
  70. CRICOTHYROID REFLEX/RECURRENT LARYNGEAL NERVE PARALYSIS
    Gayle Woodson; Fiscal Year: 1992
    The proposed research will test the hypothesis that airway obstruction in bilateral recurrent laryngeal nerve paralysis is due to reflex stimulation of the cricothyroid muscle, and that suppression of this reflex would significantly ..
  71. GOBLET CELL DYSFUNCTION IN ASTHMA
    John Fahy; Fiscal Year: 2002
    ..is a pathologic feature of animal models of asthma, and allergen-induced goblet cell degranulation causes airway obstruction in sensitized animals, the role of the goblet cell in the pathogenesis of mucus hypersecretion and airway ..
  72. MECHANISMS OF AIRWAY RESPONSES TO ORGANIC DUSTS
    Terry Gordon; Fiscal Year: 1993
    ..two cytokines known to be released in response to endotoxin, to determine whether they mimic the airway obstruction and edema observed in guinea pigs exposed to inhaled endotoxin...
  73. THORACOABDOMINAL ASYNCHRONY IN INFANT AIRWAY OBSTRUCTION
    Julian Allen; Fiscal Year: 1992
    ..motion? 3) Conversely, does resistive loaded breathing in normal infants lead to more asynchronous chest wall motion? 4) How do gestational and postnatal age affect the relationship between lung mechanics and thoraco-abdominal asynchrony?..
  74. Drug-eluting Tracheobronchial Stents to treat Obstruction caused by Lung Cancer
    Narmada Shenoy; Fiscal Year: 2007
    ..Lung cancer is one of the major diseases causing airway obstruction. According to the American Cancer Society it is the single largest cause of cancer deaths in the United ..