respiratory insufficiency

Summary

Summary: Failure to adequately provide oxygen to cells of the body and to remove excess carbon dioxide from them. (Stedman, 25th ed)

Top Publications

  1. ncbi Efficacy and economic assessment of conventional ventilatory support versus extracorporeal membrane oxygenation for severe adult respiratory failure (CESAR): a multicentre randomised controlled trial
    Giles J Peek
    Department of Cardiothoracic Surgery, Glenfield Hospital, Leicester, UK
    Lancet 374:1351-63. 2009
  2. pmc Respiratory insufficiency correlated strongly with mortality of rodents infected with West Nile virus
    John D Morrey
    Institute for Antiviral Research, Department of Animal, Dairy, and Veterinary Sciences, Utah State University, Logan, Utah, United States of America
    PLoS ONE 7:e38672. 2012
  3. pmc Failure of non-invasive ventilation in patients with acute lung injury: observational cohort study
    Sameer Rana
    Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, Minnesota USA
    Crit Care 10:R79. 2006
  4. pmc Randomised controlled trial of non-invasive ventilation (NIV) for nocturnal hypoventilation in neuromuscular and chest wall disease patients with daytime normocapnia
    S Ward
    Clinical and Academic Department of Sleep and Breathing, Royal Brompton and Harefield NHS Trust, Sydney Street, London SW3 6NP, UK
    Thorax 60:1019-24. 2005
  5. ncbi Non-invasive ventilation in acute respiratory failure
    Stefano Nava
    Respiratory Intensive Care Unit, Fondazione S Maugeri Istituto Scientifico di Pavia, IRCCS, Pavia, Italy
    Lancet 374:250-9. 2009
  6. ncbi Preoperative pulmonary risk stratification for noncardiothoracic surgery: systematic review for the American College of Physicians
    Gerald W Smetana
    Division of General Medicine and Primary Care, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Ann Intern Med 144:581-95. 2006
  7. ncbi Non-invasive ventilation in elderly patients with acute hypercapnic respiratory failure: a randomised controlled trial
    Stefano Nava
    Respiratory and Critical Care Unit, Sant Orsola Malpighi Hospital, Bologna, Italy
    Age Ageing 40:444-50. 2011
  8. ncbi Physiological effects of different interfaces during noninvasive ventilation for acute respiratory failure
    Amanda Tarabini Fraticelli
    Service de Reanimation Medicale, Groupe Hospitalier Albert Chenevier Henri Mondor, Creteil, France
    Crit Care Med 37:939-45. 2009
  9. ncbi Noninvasive ventilation in immunosuppressed patients with pulmonary infiltrates, fever, and acute respiratory failure
    G Hilbert
    Division of Medical Intensive Care, University Hospital, Bordeaux, France
    N Engl J Med 344:481-7. 2001
  10. ncbi Noninvasive ventilation in severe hypoxemic respiratory failure: a randomized clinical trial
    Miquel Ferrer
    Unitat de Vigilància Intensiva Respiratòria, Institut Clinic de Pneumologia i Cirurgia Toracica, Universitat de Barcelona, Barcelona, Spain
    Am J Respir Crit Care Med 168:1438-44. 2003

Detail Information

Publications314 found, 100 shown here

  1. ncbi Efficacy and economic assessment of conventional ventilatory support versus extracorporeal membrane oxygenation for severe adult respiratory failure (CESAR): a multicentre randomised controlled trial
    Giles J Peek
    Department of Cardiothoracic Surgery, Glenfield Hospital, Leicester, UK
    Lancet 374:1351-63. 2009
    ..We aimed to delineate the safety, clinical efficacy, and cost-effectiveness of extracorporeal membrane oxygenation (ECMO) compared with conventional ventilation support...
  2. pmc Respiratory insufficiency correlated strongly with mortality of rodents infected with West Nile virus
    John D Morrey
    Institute for Antiviral Research, Department of Animal, Dairy, and Veterinary Sciences, Utah State University, Logan, Utah, United States of America
    PLoS ONE 7:e38672. 2012
    ..Affected medullary respiratory control cells may have contributed to the animals' respiratory insufficiency, because WNV antigen staining was present in neurons located in the ventrolateral medulla...
  3. pmc Failure of non-invasive ventilation in patients with acute lung injury: observational cohort study
    Sameer Rana
    Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, Minnesota USA
    Crit Care 10:R79. 2006
    ..We sought to assess the outcome of ALI that was initially treated with NIPPV and to identify specific risk factors for NIPPV failure...
  4. pmc Randomised controlled trial of non-invasive ventilation (NIV) for nocturnal hypoventilation in neuromuscular and chest wall disease patients with daytime normocapnia
    S Ward
    Clinical and Academic Department of Sleep and Breathing, Royal Brompton and Harefield NHS Trust, Sydney Street, London SW3 6NP, UK
    Thorax 60:1019-24. 2005
    ..Individuals with nocturnal hypercapnia but daytime normocapnia were randomised to a control group or nocturnal NIV to examine whether nocturnal hypoventilation is a valid indication for NIV...
  5. ncbi Non-invasive ventilation in acute respiratory failure
    Stefano Nava
    Respiratory Intensive Care Unit, Fondazione S Maugeri Istituto Scientifico di Pavia, IRCCS, Pavia, Italy
    Lancet 374:250-9. 2009
    ..When used to prevent intubation in otherwise stable patients it can be safely administered in an adequately staffed and monitored ward...
  6. ncbi Preoperative pulmonary risk stratification for noncardiothoracic surgery: systematic review for the American College of Physicians
    Gerald W Smetana
    Division of General Medicine and Primary Care, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Ann Intern Med 144:581-95. 2006
    ..The importance of clinical risk factors for postoperative pulmonary complications and the value of preoperative testing to stratify risk are the subject of debate...
  7. ncbi Non-invasive ventilation in elderly patients with acute hypercapnic respiratory failure: a randomised controlled trial
    Stefano Nava
    Respiratory and Critical Care Unit, Sant Orsola Malpighi Hospital, Bologna, Italy
    Age Ageing 40:444-50. 2011
    ....
  8. ncbi Physiological effects of different interfaces during noninvasive ventilation for acute respiratory failure
    Amanda Tarabini Fraticelli
    Service de Reanimation Medicale, Groupe Hospitalier Albert Chenevier Henri Mondor, Creteil, France
    Crit Care Med 37:939-45. 2009
    ....
  9. ncbi Noninvasive ventilation in immunosuppressed patients with pulmonary infiltrates, fever, and acute respiratory failure
    G Hilbert
    Division of Medical Intensive Care, University Hospital, Bordeaux, France
    N Engl J Med 344:481-7. 2001
    ..Avoiding intubation is a major goal in the management of respiratory failure, particularly in immunosuppressed patients. Nevertheless, there are only limited data on the efficacy of noninvasive ventilation in these high-risk patients...
  10. ncbi Noninvasive ventilation in severe hypoxemic respiratory failure: a randomized clinical trial
    Miquel Ferrer
    Unitat de Vigilància Intensiva Respiratòria, Institut Clinic de Pneumologia i Cirurgia Toracica, Universitat de Barcelona, Barcelona, Spain
    Am J Respir Crit Care Med 168:1438-44. 2003
    ..39; p=0.017). The use of noninvasive ventilation prevented intubation, reduced the incidence of septic shock, and improved survival in these patients compared with high-concentration oxygen therapy...
  11. pmc Forkhead Box m1 transcription factor is required for perinatal lung function
    Tanya V Kalin
    Division of Pulmonary Biology, Cincinnati Children s Hospital Research Foundation, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
    Proc Natl Acad Sci U S A 105:19330-5. 2008
    ..Foxm1 is critical for surfactant homeostasis and lung maturation before birth and is required for adaptation to air breathing...
  12. pmc A potentially preventable case of serious influenza infection in a pregnant patient
    Michael D Parkins
    Department of Medicine, University of Calgary, and Calgary Health Region, Calgary, Alta
    CMAJ 177:851-3. 2007
  13. ncbi Simulated rescue airway use by laypersons with scripted telephonic instruction
    Gillian Beauchamp
    University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Resuscitation 80:925-9. 2009
    ..The King LT-D is a supraglottic airway with the potential for use by trained first responders in settings where access to advanced life support interventions by a physician or Emergency Medical Services may be delayed...
  14. ncbi Risk factors for venous thromboembolism in hospitalized patients with acute medical illness: analysis of the MEDENOX Study
    Raza Alikhan
    Academic Department of Surgery, Guy s, King s, and St Thomas School of Medicine, London, England
    Arch Intern Med 164:963-8. 2004
    ..There is limited information about risk factors for venous thromboembolism (VTE) in acutely ill hospitalized general medical patients...
  15. ncbi Noninvasive ventilation in acute respiratory failure--a meta-analysis update
    John V Peter
    Intensive Care Unit, The Queen Elizabeth Hospital, Woodville, SA, Australia
    Crit Care Med 30:555-62. 2002
    ..To present a meta-analytic update on the effects of noninvasive ventilation (NIV) in the management of acute respiratory failure...
  16. ncbi Predictors of noninvasive ventilation failure in patients with hematologic malignancy and acute respiratory failure
    Mélanie Adda
    AP HP, Hopital Saint Louis, Medical ICU, Paris, France
    Crit Care Med 36:2766-72. 2008
    ..However, failure of noninvasive ventilation may lead to an increased mortality...
  17. pmc West Nile virus-associated flaccid paralysis
    James J Sejvar
    Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Emerg Infect Dis 11:1021-7. 2005
    ..A poliomyelitislike syndrome likely involving spinal anterior horn cells is the most common mechanism of WNV-associated paralysis and is associated with significant short- and long-term illness and death...
  18. ncbi Weaning from mechanical ventilation
    J M Boles
    Dept of Medical Intensive Care and Medical Emergencies, Hôpital de la Cavale Blanche University Hospital, Universite de Bretagne Occidentale, Brest Cedex, France
    Eur Respir J 29:1033-56. 2007
    ..6) Noninvasive ventilation techniques should be considered in selected patients to shorten the duration of intubation but should not be routinely used as a tool for extubation failure...
  19. ncbi Oxygenation index predicts outcome in children with acute hypoxemic respiratory failure
    Daniel Trachsel
    Department of Critical Care Medicine, The Hospital for Sick Children, 555 University Avenue, Toronto, ON, M5G 1X8 Canada
    Am J Respir Crit Care Med 172:206-11. 2005
    ..This is best reflected by the OI, which shows a direct correlation to outcome in a time-independent manner...
  20. ncbi ABCA3 inactivation in mice causes respiratory failure, loss of pulmonary surfactant, and depletion of lung phosphatidylglycerol
    Michael L Fitzgerald
    Lipid Metabolism Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    J Lipid Res 48:621-32. 2007
    ..They also demonstrate the utility of the Abca3 null mouse as a model for a devastating human disease...
  21. ncbi Hyperglycaemia as a predictor of outcome during non-invasive ventilation in decompensated COPD
    B Chakrabarti
    Clinical Sciences Centre, University Hospital Aintree, University of Liverpool, Liverpool L9 7AL, UK
    Thorax 64:857-62. 2009
    ..Hyperglycaemia predicts a poor outcome in Intensive Care Unit (ICU) patients. Whether this is true for respiratory failure necessitating non-invasive ventilation (NIV) is not known...
  22. ncbi The prognosis of acute respiratory failure in critically ill cancer patients
    Elie Azoulay
    Medical Intensive Care Unit, Biostatistics Department, Saint Louis Hospital and Paris 7 University, Paris, France
    Medicine (Baltimore) 83:360-70. 2004
    ..The impact of conventional mechanical ventilation on survival depends on the time from ICU admission to conventional mechanical ventilation and on the patient's response to noninvasive mechanical ventilation...
  23. ncbi Noninvasive positive-pressure ventilation in acute respiratory failure outside clinical trials: experience at the Massachusetts General Hospital
    Guilherme Schettino
    Harvard Medical School and Massachusetts General Hospital, Boston, MA, USA
    Crit Care Med 36:441-7. 2008
    ..However, few data are available on the use of NPPV as routine standard medical care for patients with respiratory failure outside of controlled trials...
  24. ncbi Increased use of noninvasive ventilation in French intensive care units
    Alexandre Demoule
    Service de Reanimation Medicale, AP HP, Hopital Henri Mondor, 51 Av du Mal de Lattre de Tassigny, 94000, Creteil, France
    Intensive Care Med 32:1747-55. 2006
    ..A prospective survey of French intensive care units (ICUs) in 1997 showed moderate and variable use of noninvasive ventilation (NIV). This study examined changes in NIV use in French ICUs after the intervening 5years...
  25. ncbi Extracorporeal membrane oxygenation in severe hypoxemia: time for reappraisal?
    Luciano Cesar Pontes Azevedo
    Hospital Sirio Libanes, São Paulo SP Brasil
    J Bras Pneumol 38:7-12. 2012
    ..In this article, we discuss the indications for using ECMO and report the case of a patient with refractory hypoxemia who was successfully treated with ECMO...
  26. ncbi Sleep and non-invasive ventilation in patients with chronic respiratory insufficiency
    Cristina Ambrogio
    University of Torino, Turin, Italy
    Intensive Care Med 35:306-13. 2009
    ..We tested the hypothesis that in patients with chronic respiratory insufficiency, a newer mode of ventilation [averaged volume assured pressure support (AVAPS)] and lateral decubitus ..
  27. ncbi Extracorporeal membrane oxygenation in adults with severe respiratory failure: a multi-center database
    Thomas V Brogan
    Division of Critical Care Medicine, Department of Pediatrics, Seattle Children s Hospital, University of Washington School of Medicine, Seattle, WA, USA
    Intensive Care Med 35:2105-14. 2009
    ..To evaluate clinical and treatment factors for patients recorded in the Extracorporeal Life Support Organization (ELSO) registry and survival of adult extracorporeal membrane oxygenation (ECMO) respiratory failure patients...
  28. pmc Cerebral and peripheral tissue oxygenation in children supported on ECMO for cardio-respiratory failure
    Maria D Papademetriou
    Biomedical Optics Research Laboratory, Department of Medical Physics and Bioengineering, University College London, Gower Street, London WC1E 6BT, UK
    Adv Exp Med Biol 662:447-53. 2010
    ..Spectral analysis was performed on the oxyhaemoglobin data collected from these patients with the aim of comparing oscillations at range of frequencies appearing in the two measurement sites...
  29. ncbi [Mechanical ventilation noninvasive with positive pressure]
    Guilherme P P Schettino
    J Bras Pneumol 33:S92-105. 2007
  30. ncbi Benefits and risks of success or failure of noninvasive ventilation
    Alexandre Demoule
    Service de Reanimation Medicale, AP HP, Hopital Henri Mondor, 51 Av du Mal de Lattre de Tassigny, 94000, Creteil, France
    Intensive Care Med 32:1756-65. 2006
    ..The impact of NIV failure and success was compared between de novo and CPE or AOC after adjustment for disease severity...
  31. pmc West Nile Virus-associated flaccid paralysis outcome
    James J Sejvar
    Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention CDC, Atlanta, Georgia 30333, USA
    Emerg Infect Dis 12:514-6. 2006
    ..As in the 4-month follow-up, a variety of recovery patterns were observed, but persistent weakness was frequent. Respiratory involvement was associated with considerable illness and death...
  32. ncbi Characterizing the need for mechanical ventilation following cervical spinal cord injury with neurologic deficit
    John J Como
    Case Western Reserve University School of Medicine, MetroHealth Medical Center, Department of Surgery, Division of Trauma, Critical Care, Burns, and Metro Life Flight, Cleveland, OH 44109, USA
    J Trauma 59:912-6; discussion 916. 2005
    ..The purpose of this study was to characterize factors associated with a high risk for respiratory failure and/or the need for mechanical ventilation in C-SCI patients...
  33. pmc Acute exacerbations and respiratory failure in chronic obstructive pulmonary disease
    Neil MacIntyre
    Duke University Medical Center, Durham, NC 27710, USA
    Proc Am Thorac Soc 5:530-5. 2008
    ..Although mild episodes of AECOPD are generally reversible, more severe forms of respiratory failure are associated with a substantial mortality and a prolonged period of disability in survivors...
  34. ncbi Extracorporeal membrane oxygenation as a bridge to lung transplant: midterm outcomes
    Christian A Bermudez
    Department of Cardiothoracic Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
    Ann Thorac Surg 92:1226-31; discussion 1231-2. 2011
    ..The impact on mid-term survival is unknown. We analyzed outcomes after lung transplant over a 19-year period in patients who received ECMO support...
  35. ncbi Noninvasive ventilation and weaning in patients with chronic hypercapnic respiratory failure: a randomized multicenter trial
    Christophe Girault
    Department of Medical Intensive Care, Rouen University Hospital, Rouen, France
    Am J Respir Crit Care Med 184:672-9. 2011
    ..The use of noninvasive ventilation (NIV) as an early weaning/extubation technique from mechanical ventilation remains controversial...
  36. ncbi The total face mask is more comfortable than the oronasal mask in noninvasive ventilation but is not associated with improved outcome
    Fernando Hauaji Chacur
    Department of Respiratory Disease, Pro Cardíaco Hospital, Rio de Janeiro, Brazil
    Respiration 82:426-30. 2011
    ..A total face mask was designed to increase compliance, but whether this translates into better outcome (improvement in clinical and blood gas parameters and less intubation) is unknown...
  37. ncbi Current status of extracorporeal life support (ECMO) for cardiopulmonary failure
    R H Bartlett
    Department of Surgery, University of Michigan Medical School, Ann Arbor, MI, USA
    Minerva Anestesiol 76:534-40. 2010
    ..The next decade may bring routine application of ECMO to all advanced Intensive Care Units where patients with profound respiratory and cardiac failure are treated...
  38. ncbi The sequence polymorphism of MnSOD gene in subjects with respiratory insufficiency in COPD
    Tadeusz Pietras
    Department of Pneumology and Allergology, Medical University of Lodz, Lodz, Poland
    Med Sci Monit 16:CR427-32. 2010
    ..failure, which, in turn, exposes the tissues to oxidative stress, which is both a cause and a result of respiratory insufficiency. The first-line defense against oxidative stress is provided by the mitochondrial enzyme manganese ..
  39. ncbi Respiratory insufficiency in desminopathy patients caused by introduction of proline residues in desmin c-terminal alpha-helical segment
    Ayush Dagvadorj
    Clinical Neurogenetics Unit, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bldg 10, Room 4B37, 10 Central Dr, MSC 1361, Bethesda, Maryland 20892 1361, USA
    Muscle Nerve 27:669-75. 2003
    ..families with unusual features of adult-onset, slowly progressive, diffuse skeletal myopathy and respiratory insufficiency. Progressive reduction of respiratory muscle strength became clinically detectable between the 3rd and ..
  40. ncbi Fatal familial lung disease caused by ABCA3 deficiency without identified ABCA3 mutations
    W Adam Gower
    Department of Pediatrics, The Johns Hopkins University School of Medicine, Baltimore, MD 21287 2533, USA
    J Pediatr 157:62-8. 2010
    ..To test the hypothesis that some functionally significant variants in the gene encoding member A3 of the ATP Binding Cassette family (ABCA3) are not detected using exon-based sequencing approaches...
  41. ncbi Quality of life, physical disability, and respiratory impairment in Duchenne muscular dystrophy
    Malcolm Kohler
    Pulmonary Division, Department of Internal Medicine, University Hospital of Zurich, Raemistrasse 100, CH 8091 Zurich, Switzerland
    Am J Respir Crit Care Med 172:1032-6. 2005
    ..The assumption that severe physical disability precludes an acceptable quality of life is common, but has not been specifically evaluated in DMD...
  42. ncbi A case of nemaline myopathy with associated dilated cardiomyopathy and respiratory failure
    Rihito Nagata
    Department of Cardiology, Yaizu City Hospital, Shizuoka, Japan
    Int Heart J 52:401-5. 2011
    ..His general condition has been stable during a 10-month follow up period...
  43. ncbi The effects of respiratory failure on delivery in pregnant patients with H1N1 2009 influenza
    Anahita Jafari
    Department of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, Stanford University School of Medicine, Stanford, California, USA
    Obstet Gynecol 115:1033-5. 2010
    ..Here we describe the obstetric and critical care treatment of three patients with confirmed H1N1 influenza virus infection complicated by acute respiratory failure...
  44. ncbi Respiratory changes in inferior vena cava diameter are helpful in predicting fluid responsiveness in ventilated septic patients
    Christophe Barbier
    Medical and Surgical Intensive Care Unit, Hospital St Germain en Laye, 20 rue Armagis, 78100 St Germain en Laye, France
    Intensive Care Med 30:1740-6. 2004
    ..To evaluate the extent to which respiratory changes in inferior vena cava (IVC) diameter can be used to predict fluid responsiveness...
  45. ncbi Effects of inhaled nitric oxide in neonatal hypoxemic respiratory failure from a multicenter controlled trial
    Yi Fei Wang
    Department of Pediatrics and Neonatology, Children s Hospital of Fudan University, Laboratory of Neonatology, Ministry of Health, Shanghai, China
    Chin Med J (Engl) 124:1156-63. 2011
    ..The aim of this study was to investigate effects of iNO in neonates with HRF in resource limited condition with no or limited use of surfactant, high frequency oscillatory ventilation (HFOV) and extracorporeal membrane oxygenation...
  46. ncbi Prehospital intubation in severe thoracic trauma without respiratory insufficiency: a matched-pair analysis based on the Trauma Registry of the German Trauma Society
    Steffen Ruchholtz
    Department of Trauma Surgery, Institute for Medical Informatics, Biometrics and Epidemiology, University Hospital of Essen, Essen, Germany
    J Trauma 52:879-86. 2002
    On the basis of the data of a multicenter study, the impact of prehospital intubation and ventilation in the therapy of severe thoracic trauma without manifest respiratory insufficiency was analyzed.
  47. pmc Post-mortem histological pulmonary analysis in patients with HIV/AIDS
    Alexandre de Matos Soeiro
    Pathology, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, Brazil
    Clinics (Sao Paulo) 63:497-502. 2008
    ..This study considers 250 autopsies of HIV/AIDS patients who died of acute respiratory failure and describes the demographic data, etiology, and histological pulmonary findings of the various pathologies...
  48. ncbi Etiologies and outcome of acute respiratory failure in HIV-infected patients
    Francois Barbier
    Medical ICU and Infectious Disease Department, AP HP, Hopital Saint Louis, 1 avenue Claude Vellefaux, 75010, Paris, France
    Intensive Care Med 35:1678-86. 2009
    ..To assess the etiologies and outcome of acute respiratory failure (ARF) in HIV-infected patients over the first decade of combination antiretroviral therapy (ART) use...
  49. ncbi Respiratory failure induced by acute organophosphate poisoning in rats: effects of vagotomy
    Romolo J Gaspari
    Department of Emergency Medicine, University of Massachusetts School of Medicine, Worcester, MA 01655, USA
    Neurotoxicology 30:298-304. 2009
    ....
  50. pmc Inspiratory muscle strength training improves weaning outcome in failure to wean patients: a randomized trial
    A Daniel Martin
    Department of Physical Therapy, University of Florida, 1600 South West Archer Road, PO Box 100154, Gainesville, FL 32610, USA
    Crit Care 15:R84. 2011
    ..MV induced inspiratory muscle weakness has been implicated as a contributor to FTW and recent work has documented inspiratory muscle weakness in humans supported with MV...
  51. ncbi Long-term home ventilation of children in Italy: a national survey
    F Racca
    Department of Anesthesiology and Intensive Care Medicine, San Giovanni Battista Molinette Hospital, University of Turin, Turin, Italy
    Pediatr Pulmonol 46:566-72. 2011
    ..However, the profile of this growing population, the quality and adequacy of home care, and patients' needs still require thorough assessment...
  52. ncbi The use of noninvasive ventilation in acute respiratory failure at a tertiary care center
    Elizabeth S Paus-Jenssen
    Department of Medicine, Royal University Hospital, Saskatoon, SK, Canada
    Chest 126:165-72. 2004
    ..We surveyed the use of treatment with noninvasive ventilation (NIV) in clinical practice by physicians in a tertiary care, university-based teaching hospital and compared our findings with published recommendations for the use of NIV...
  53. ncbi Prediction of respiratory insufficiency in Guillain-Barré syndrome
    Christa Walgaard
    Department of Neurology, Erasmus Medical Center, Rotterdam, The Netherlands
    Ann Neurol 67:781-7. 2010
    b>Respiratory insufficiency is a frequent and serious complication of the Guillain-Barré syndrome (GBS)...
  54. ncbi Initial experience with single cannulation for venovenous extracorporeal oxygenation in adults
    Christian A Bermudez
    Heart, Lung, and Esophageal Surgery Institute, Pittsburgh, Pennsylvania, USA
    Ann Thorac Surg 90:991-5. 2010
    ..A single-venous cannulation strategy may facilitate implantation and patient mobilization. Here we present our early experience with a single cannulation technique...
  55. ncbi Life-threatening respiratory failure from H1N1 influenza 09 (human swine influenza)
    Melissa A Kaufman
    Northern Hospital, Melbourne, Vic, Australia
    Med J Aust 191:154-6. 2009
    ..These cases highlight the small but significant risk of life-threatening respiratory failure associated with H1N1 influenza 09 infection...
  56. ncbi Bronchioalveolar lavage with perfluorochemical liquid during conventional ventilation
    Rolf Lindemann
    Paediatric Intensive Care Unit, Department of Paediatrics, Ulleval University Hospital, University of Oslo, Oslo, Norway
    Pediatr Crit Care Med 8:486-8. 2007
    ..In many circumstances, bronchioalveolar lavage has been performed in conjunction with extracorporeal membrane oxygenation...
  57. ncbi Factors associated with noninvasive ventilation failure in postoperative acute respiratory insufficiency: an observational study
    Florent Wallet
    Anaesthesiology and Surgical Critical Care Department, Lyon University Croix Rousse Hospital, Lyon, France
    Eur J Anaesthesiol 27:270-4. 2010
    ..Few data are available on the efficacy of noninvasive ventilation (NIV) in postoperative patients with acute respiratory failure (ARF)...
  58. ncbi Respiratory failure
    C Roussos
    Dept of Critical Care, University of Athens Medical School, Evangelismos Hospital, Athens, Greece
    Eur Respir J Suppl 47:3s-14s. 2003
    ..Modulation of the pattern of breathing, however, ultimately results in alveolar hypoventilation and carbon dioxide retention...
  59. pmc Neural deficits contribute to respiratory insufficiency in Pompe disease
    Lara R DeRuisseau
    Department of Physiological Sciences, College of Veterinary Medicine, University of Florida, Gainesville, FL 32610, USA
    Proc Natl Acad Sci U S A 106:9419-24. 2009
    ..We conclude that neural output to the diaphragm is deficient in Gaa(-/-) mice, and therapies targeting muscle alone may be ineffective in Pompe disease...
  60. pmc Acute respiratory failure in the elderly: etiology, emergency diagnosis and prognosis
    Patrick Ray
    Department of Emergency Medicine and Surgery, Centre Hospitalo Universitaire Pitie Salpetriere, Assistance Publique Hopitaux de Paris, Université Pierre et Marie Curie Paris 6 75651 Paris Cedex 13, France
    Crit Care 10:R82. 2006
    ..Our objectives were to determine the causes of acute respiratory failure (ARF) in elderly patients and to assess the accuracy of the initial diagnosis by the emergency physician, and that of the prognosis...
  61. ncbi The kinase domain of titin controls muscle gene expression and protein turnover
    Stephan Lange
    Muscle Signalling and Development, Randall Division, King s College London, London SE1 1UL, UK
    Science 308:1599-603. 2005
    ..A human mutation in the titin protein kinase domain causes hereditary muscle disease by disrupting this pathway...
  62. ncbi Noninvasive vs. conventional mechanical ventilation in patients with chronic obstructive pulmonary disease after failure of medical treatment in the ward: a randomized trial
    G Conti
    Universita Cattolica del S Cuore, Policlinico A Gemelli, Largo F Vito, 00168 Rome, Italy
    Intensive Care Med 28:1701-7. 2002
    ....
  63. ncbi Strategies to reduce postoperative pulmonary complications after noncardiothoracic surgery: systematic review for the American College of Physicians
    Valerie A Lawrence
    South Texas Veterans Health Care System and Medicine General Medicine, The University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229 3900, USA
    Ann Intern Med 144:596-608. 2006
    ..However, there has been much less research and no previous systematic reviews of the evidence of interventions to prevent pulmonary complications...
  64. ncbi Noninvasive positive pressure ventilation in the acute care setting: where are we?
    N Ambrosino
    Pulmonary and Respiratory Intensive Care Unit, Cardio Thoracic Dept, University Hospital Pisa, Italy
    Eur Respir J 31:874-86. 2008
    ..Additionally, the technique must be applied in the appropriate location by a trained team in order to avoid disappointing results...
  65. pmc Infection rate and acute organ dysfunction risk as explanations for racial differences in severe sepsis
    Florian B Mayr
    CRISMA Laboratory, Department of Critical Care Medicine, University of Pittsburgh, 3550 Terrace St, Pittsburgh, PA 15261, USA
    JAMA 303:2495-503. 2010
    ..Severe sepsis, defined as infection complicated by acute organ dysfunction, occurs more frequently and leads to more deaths in black than in white individuals. The optimal approach to minimize these disparities is unclear...
  66. ncbi Effect of the humidification device on the work of breathing during noninvasive ventilation
    Francois Lellouche
    Medical Intensive Care Unit, Hopital Henri Mondor, AP HP, Université Paris 12 et INSERM U492, 51 Av du Marechal de Lattre de Tassigny, 94010 Creteil, France
    Intensive Care Med 28:1582-9. 2002
    ..This study compared the effect of HH and HME during noninvasive ventilation (NIV) on arterial blood gases and patient's effort assessed by respiratory muscles pressure-time product and by work of breathing (WOB)...
  67. ncbi Acute respiratory failure in patients with severe community-acquired pneumonia. A prospective randomized evaluation of noninvasive ventilation
    M Confalonieri
    Unità Operativa di Pneumologia, Ospedale Civile di Piacenza, Piacenza, Italy
    Am J Respir Crit Care Med 160:1585-91. 1999
    ..A 2-mo survival advantage was seen in patients with COPD...
  68. ncbi Long-term non-invasive ventilation in COPD after acute-on-chronic respiratory failure
    Georg Christian Funk
    Department of Respiratory and Critical Care Medicine and Ludwig Boltzmann Institute for COPD, Otto Wagner Hospital, Vienna, Austria
    Respir Med 105:427-34. 2011
    ..Long-term nocturnal non-invasive ventilation (NIV) may be beneficial for these patients. We hypothesized that stable patients on long-term NIV would experience clinical worsening after withdrawal of NIV...
  69. ncbi Average volume-assured pressure support in obesity hypoventilation: A randomized crossover trial
    Jan Hendrik Storre
    Department of Pneumology, University Hospital Freiburg, Killianstrasse 5, D 79106 Freiburg, Germany
    Chest 130:815-21. 2006
    ..There is a particular need to better define the most efficient ventilatory treatment modality for patients with obesity hypoventilation syndrome (OHS)...
  70. ncbi Acute respiratory failure in the United States: incidence and 31-day survival
    C E Behrendt
    Children s Hospital, San Diego, CA, USA
    Chest 118:1100-5. 2000
    ..To estimate the incidence of acute respiratory failure (ARF) in the United States and to analyze 31-day hospital mortality among a cohort of patients with ARF...
  71. ncbi Early predictors of mechanical ventilation in Guillain-Barré syndrome
    Tarek Sharshar
    Medical Intensive Care Unit, Raymond Poincaré Teaching Hospital, Garches, France
    Crit Care Med 31:278-83. 2003
    ..Although mechanical ventilation is required in 30% of patients with Guillain-Barré syndrome, early predictors of this treatment remain unknown...
  72. ncbi Use of inspiratory muscle strength training to facilitate ventilator weaning: a series of 10 consecutive patients
    A Daniel Martin
    Department of Physical Therapy, University of Florida, Gainesville, FL, USA
    Chest 122:192-6. 2002
    ....
  73. pmc Readmission rates and life threatening events in COPD survivors treated with non-invasive ventilation for acute hypercapnic respiratory failure
    C M Chu
    Division of Respiratory Medicine, Department of Medicine and Geriatrics, United Christian Hospital, Kowloon, Hong Kong, SAR, China
    Thorax 59:1020-5. 2004
    ..However, little information exists on the outcomes following discharge. A study was undertaken to examine the rates of readmission, recurrent AHRF, and death following discharge and the risk factors associated with them...
  74. pmc Treatment of respiratory failure in COPD
    Stephan Budweiser
    Center for Pneumology, Hospital Donaustauf, Donaustauf, Germany
    Int J Chron Obstruct Pulmon Dis 3:605-18. 2008
    ..Such studies might preferentially recruit patients with repeated hypercapnic decompensation or a high risk for death, while ensuring effective ventilation and the patients' adherence to therapy...
  75. ncbi Neonatal spinal muscular atrophy with multiple contractures, bone fractures, respiratory insufficiency and 5q13 deletion
    M A García-Cabezas
    Departamento de Anatomia Patologica, Hospital Universitario La Paz, Pso de la Castellana 261, 28046 Madrid, Spain
    Acta Neuropathol 107:475-8. 2004
    We present the case of a floppy neonate with marked and generalized weakness, respiratory insufficiency and fetal akinesia deformation sequence...
  76. ncbi Influence of total face, facial and nasal masks on short-term adverse effects during noninvasive ventilation
    Marcelo Alcantara Holanda
    Department of Clinical Medicine, School of Medicine, Federal University of Ceara, Fortaleza, Brazil
    J Bras Pneumol 35:164-73. 2009
    ..The aim of this study was to compare the incidence, type and intensity of adverse effects, as well as the comfort, of total face masks (TFMs), facial masks (FMs) and nasal masks (NMs) during NIV...
  77. ncbi Comparison of noninvasive positive pressure ventilation with standard medical therapy in hypercapnic acute respiratory failure
    T Celikel
    Department of Pulmonary and Critical Care Medicine, Marmara University Hospital, Istanbul, Turkey
    Chest 114:1636-42. 1998
    ..To compare the efficacy of standard medical therapy (ST) and noninvasive mechanical ventilation additional to standard medical therapy in hypercapnic acute respiratory failure (HARF)...
  78. ncbi Extracorporeal membrane oxygenation for pandemic H1N1 2009 respiratory failure
    B Holzgraefe
    Section for Anaesthesiology and Intensive Care Medicine, Department of Physiology and Pharmacology, Paediatric Anaesthesia and Intensive Care, ECMO Center Karolinska, Karolinska Institute and Karolinska University Hospital Solna, Stockholm, Sweden
    Minerva Anestesiol 76:1043-51. 2010
    ..If, in spite of maximal conventional critical care, the patient's condition deteriorates, extracorporeal membrane oxygenation (ECMO) may be a life-saving procedure...
  79. pmc Effect of noninvasive mechanical ventilation in elderly patients with hypercapnic acute-on-chronic respiratory failure and a do-not-intubate order
    Paolo Scarpazza
    Divisione di Broncopneumotisiologia, Ospedale Civile, Vimercate, Italy
    Int J Chron Obstruct Pulmon Dis 3:797-801. 2008
    ..We conclude that elderly patients with acute hypercapnic ARF with a DNI status can be successfully treated by NIMV...
  80. ncbi Pulmonary histopathological alterations in patients with acute respiratory failure: an autopsy study
    Alexandre de Matos Soeiro
    Faculdade de Medicina da Universidade de Sao Paulo FMUSP, University of Sao Paulo School of Medicine, Sao Paulo, Brazil
    J Bras Pneumol 34:67-73. 2008
    ....
  81. ncbi Multivariable predictors of postoperative respiratory failure after general and vascular surgery: results from the patient safety in surgery study
    Robert G Johnson
    Saint Louis University and the John Cochran VA Medical Center, St Louis, MO 63110, USA
    J Am Coll Surg 204:1188-98. 2007
    ..This model is an extension of an earlier model that was derived and tested exclusively from a population of male patients from the Veterans Affairs National Surgical Quality Improvement Program...
  82. ncbi Correlation between surgical lung biopsy and autopsy findings and clinical data in patients with diffuse pulmonary infiltrates and acute respiratory failure
    Mauro Canzian
    Division of Respiratory Diseases, Heart Institute, Sao Paulo University Medical School, Sao Paulo, SP, Brazil
    Clinics (Sao Paulo) 61:425-32. 2006
    ..Surgical lung biopsy is an invasive procedure performed when other procedures have failed to provide an urgent and specific diagnosis, but there may be reluctance to perform it in critically ill patients with diffuse pulmonary infiltrates...
  83. ncbi The changing epidemiology of mechanical ventilation: a population-based study
    Shannon S Carson
    Department of Medicine and the Cecil G Sheps Center for Health Services Research, University of North Carolina, Chapel Hill, NC 27599 7020, USA
    J Intensive Care Med 21:173-82. 2006
    ..4% to 34.4%, and discharges to nursing homes grew from 7.3% to 10.7%. The incidence of mechanical ventilation is increasing, and the increase is associated with a higher burden of comorbidities and fewer discharges to home...
  84. ncbi Neuromuscular disease causing acute respiratory failure
    Sangeeta Mehta
    Interdepartmental Division of Critical Care Medicine, Mount Sinai Hospital, 600 University Avenue, Toronto, Ontario, M5G 1X5, Canada
    Respir Care 51:1016-21; discussion 1021-3. 2006
    ....
  85. ncbi Pulmonary complications of chronic neuromuscular diseases and their management
    Christophe Perrin
    Division of Pulmonary, Critical Care, and Sleep Medicine, Tufts New England Medical Center, Tufts University School of Medicine, 750 Washington Street, Boston, Massachusetts 02111 1526, USA
    Muscle Nerve 29:5-27. 2004
    ..For patients considered unsuitable for noninvasive ventilation, invasive mechanical ventilation should be considered, but only after a frank but compassionate discussion between the patient, family, physician, and other caregivers...
  86. ncbi Impact of open lung biopsy on refractory acute respiratory failure
    Carmen Silvia Valente Barbas
    Intensive Care Unit, Hospital Israelita Albert Einstein, Sao Paulo, Brazil
    J Bras Pneumol 32:418-23. 2006
    ....
  87. ncbi Utilization of noninvasive ventilation in acute care hospitals: a regional survey
    Vinay Maheshwari
    Division of Pulmonary, Critical Care and Sleep Medicine, Tufts New England Medical Center, 750 Washington St, No 257, Boston, MA 02111, USA
    Chest 129:1226-33. 2006
    ....
  88. ncbi The treatment of spine and chest wall deformities with fused ribs by expansion thoracostomy and insertion of vertical expandable prosthetic titanium rib: growth of thoracic spine and improvement of lung volumes
    John B Emans
    Department of Orthopaedic Surgery, Children s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Spine (Phila Pa 1976) 30:S58-68. 2005
    ..Prospective clinical trial of vertical expandable prosthetic titanium rib (VEPTR) in patients with combined spine and chest wall deformity with scoliosis and fused ribs...
  89. ncbi Diagnostic bronchoscopy in hematology and oncology patients with acute respiratory failure: prospective multicenter data
    Elie Azoulay
    Intensive Care Unit, Saint Louis Teaching Hospital, Paris, France
    Crit Care Med 36:100-7. 2008
    ..To describe the diagnostic yields of test strategies with and without fiberoptic bronchoscopy and bronchoalveolar lavage (FO-BAL), as well as outcomes, in cancer patients with acute respiratory failure (ARF)...
  90. ncbi Predicting the result of noninvasive ventilation in severe acute exacerbations of patients with chronic airflow limitation
    A Anton
    Department of Respiratory Medicine, Hospital de la Santa Creu i Sant Pau, Universitat Autonoma de Barcelona, Barcelona, Spain
    Chest 117:828-33. 2000
    ....
  91. ncbi Noninvasive mechanical ventilation in patients having declined tracheal intubation
    Elie Azoulay
    Medical ICU, Saint Louis Hospital AP HP, Medical ICU, Faculte de Medecine, Universite Paris Diderot, Sorbonne Paris Cité, 1 avenue Claude Vellefaux, 75010 Paris, France
    Intensive Care Med 39:292-301. 2013
    ..The aim of our study was to report outcomes after NIV in patients with a do-not-intubate (DNI) order...
  92. pmc Noninvasive respiratory management of high level spinal cord injury
    John R Bach
    Department of Physical Medicine and Rehabilitation, University Hospital, NY, USA
    J Spinal Cord Med 35:72-80. 2012
    ....
  93. ncbi Recommendations to improve healthcare of neonates with respiratory insufficiency beneficiaries of Seguro Popular
    Luis Jasso-Gutiérrez
    Departamento de Evaluación y Análisis de Medicamentos, Hospital Infantil de Mexico Federico Gomez, Mexico
    Salud Publica Mex 54:S57-64. 2012
    To evaluate the structure and processes of care of neonatal intensive care units (NICU) providing health care to neonates with respiratory insufficiency, and financed by Seguro Popular.
  94. ncbi Critical care challenges in the adult ECMO patient
    Sarah E Gay
    Duke University School of Nursing, Durham, North Carolina, USA
    Dimens Crit Care Nurs 24:157-62; quiz 163-4. 2005
    ..Although ECMO is not new to the intensive care unit setting, it is usually considered a last resort measure in the adult population. ECMO may save a life and present an awarding challenge to the intensive care unit nurse...
  95. ncbi Definitive establishment of airway control is critical for optimal outcome in lower cervical spinal cord injury
    Victor J Hassid
    Department of Surgery, University of Florida Health Science Center, Jacksonville, Florida 32209, USA
    J Trauma 65:1328-32. 2008
    ..This study sought to determine the incidence and effect of catastrophic airway loss (CLA) and to define the need for elective intubation with subsequent tracheostomy to prevent potentially fatal outcomes...
  96. ncbi Performance of the coughassist insufflation-exsufflation device in the presence of an endotracheal tube or tracheostomy tube: a bench study
    Claude Guerin
    Service de Réanimation Médicale et d Assistance Respiratoire, Hopital de la Croix Rousse, Lyon, France
    Respir Care 56:1108-14. 2011
    ..The device may benefit intubated and tracheotomized patients. We assessed the impact of various artificial airways on peak expiratory flow (PEF) with the CoughAssist...
  97. ncbi Reduction of the PaO2/FiO2 ratio in acute aortic dissection – relationship between the extent of dissection and inflammation –
    Manabu Kurabayashi
    Department of Cardiology, Yokohama City Minato Red Cross Hospital, Yokohama, Japan
    Circ J 74:2066-73. 2010
    ..Acute aortic dissection (AAD) often accompanies acute respiratory failure. The aim of this study was to clarify the relationship between the incidence of oxygenation impairment and the extent of distal type AAD...
  98. ncbi Failed rescue therapy with rapamycin after paraquat intoxication
    Johan Matthes Lorenzen
    Department of Internal Medicine, Medical School Hannover, Hannover, Germany
    Clin Toxicol (Phila) 48:84-6. 2010
    ..Maximum rapamycin concentrations amounted to 12.9 microg/L. Despite these efforts, the patient died on day 18 after intoxication from respiratory failure caused by severe pulmonary fibrosis...
  99. ncbi Long-term survival according to ventilation mode in acute respiratory failure secondary to chronic obstructive pulmonary disease: a multicenter, inception cohort study
    Johan Berkius
    Department of Anesthesia and Intensive Care, Västervik Hospital, Västervik, Sweden
    J Crit Care 25:539.e13-8. 2010
    ..The aim of the study was to investigate 5-year survival stratified by mechanical ventilation modality in chronic obstructive pulmonary disease (COPD) patients treated in the ICU...
  100. ncbi Proportional assist ventilation and neurally adjusted ventilatory assist
    Robert M Kacmarek
    Department of Anesthesiology, Massachusetts General Hospital, Boston, MA, USA
    Respir Care 56:140-8; discussion 149-52. 2011
    ..This paper discusses PAV's and NAVA's theory of operation, general process of application, and the supporting literature...
  101. ncbi Noninvasive ventilation for critical care
    Erik Garpestad
    Division of Pulmonary, Critical Care and Sleep Medicine, Tufts New England Medical Center, 750 Washington St, Boston, MA 02111, USA
    Chest 132:711-20. 2007
    ..NIV is currently used in only a select minority of patients with acute respiratory failure, but with technical advances and new evidence on its proper application, this role is likely to further expand...

Research Grants62

  1. Development of Natural Orifice Translumenal Endoscopic Neurostimulation
    Anthony Ignagni; Fiscal Year: 2007
    ..Overall the proposed research is intended to advance ventilatory care for patients with respiratory insufficiency. The long-term goal of this technology is to: 1) develop translumenal mapping instrumentation and ..
  2. Resuscitation of smoke inhalation and burn injury with a thioredoxin mimetic
    ANDREW LURIE SALZMAN; Fiscal Year: 2012
    ..We will carry out a prospective, placebo-controlled, randomized, double-blinded, study in which respiratory insufficiency is induced in mechanically-ventilated Merino sheep by acute SIBI...
  3. Macrophage-based Human Gene Therapy for Hereditary PAP
    Bruce C Trapnell; Fiscal Year: 2012
    ..by the progressive accumulation of surfactant in alveolar macrophages (AM) and alveoli, resulting in respiratory insufficiency and, in severe cases, respiratory failure...
  4. Respiratory motor control and blood pressure regulation after spinal cord injury
    ALEXANDER VLADIMIROVICH OVECHKIN; Fiscal Year: 2013
    ..Another common impediment to rehabilitation after SCI is respiratory insufficiency due to paresis and paralysis of respiratory muscles...
  5. ANDV Induced Responses of Hypoxic Endothelial Cells
    Erich R Mackow; Fiscal Year: 2012
    ..ECs) and HPS is characterized by thrombocytopenia, hypoxia and acute pulmonary edema that leads to respiratory insufficiency. ANDV infection of ECs provides a primary means for hantaviruses to alter vascular permeability...
  6. Intravenous Protein Therapy for Treatment of Congenital Muscular Dystrophy
    Bradley L Hodges; Fiscal Year: 2010
    ..muscular dystrophy and is characterized by hypotonia, elevated serum CK, delayed motor milestones, respiratory insufficiency, feeding difficulties, joint contractures and scoliosis, and in some patients mental retardation and ..
  7. Control of Breathing and Pompe Disease
    David D Fuller; Fiscal Year: 2013
    ..The overall innovation of this work is that we are developing new AAV9 based therapies for respiratory insufficiency in Pompe disease...
  8. Role of GM-CSF in Myeloid Cell Function and Innate Immunity
    Bruce C Trapnell; Fiscal Year: 2013
    ..autoantibodies or GM-CSF receptor mutations, causes pulmonary alveolar proteinosis (PAP), a syndrome of respiratory insufficiency due to surfactant accumulation in alveoli caused by reduced clearance by alveolar macrophages...
  9. Mechanisms of respiratory long-term facilitation
    Gordon S Mitchell; Fiscal Year: 2013
    ..therapeutic strategies for severe ventilatory control disorders, including obstructive sleep apnea and respiratory insufficiency in patients with spinal injury or motor neuron disease (ALS)...
  10. Effective Delivery of Pharmaceutical Aerosols during Non-Invasive Ventilation
    P Worth Longest; Fiscal Year: 2012
    ..Non-invasive ventilation (NIV) is currently a form of standard care for patients suffering from respiratory insufficiency, sleep apnea, chronic obstructive pulmonary disease (COPD) and more severe acute and chronic respiratory ..
  11. Respiratory Plasticity in the SOD1g93a Rat
    GORDON STEWART MITCHELL; Fiscal Year: 2011
    ..Most ALS patients develop severe respiratory insufficiency and, ultimately, die from ventilatory failure...
  12. Predictive Modeling for Treatment of Upper Airway Obstruction in Young Children
    Carlton J Zdanski; Fiscal Year: 2013
    ..by applicant): Infants and children with abnormalities of the upper airway are at risk for hypoxia, respiratory insufficiency and long term morbidity...
  13. Spinal and brainstem respiratory neurons in Pompe disease
    David D Fuller; Fiscal Year: 2013
    ..R21 grant application will provide fundamental, mechanistic information about the clinical problem of respiratory insufficiency in Pompe disease...
  14. Chibby and Wnt Signaling in Ciliated Cell Differentiation
    Ken Ichi Takemaru; Fiscal Year: 2013
    ..and human patients with dysfunctional cilia suffer from recurrent respiratory infections, leading to respiratory insufficiency. Therefore, understanding mechanisms of motile cilia formation and ciliated cell differentiation is ..
  15. Mechanisms and therapies for respiratory muscle failure
    Ahlke Heydemann; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): This application proposes to study respiratory insufficiency associated with progressive muscle degenerative disorders...
  16. Therapeutic Interventions Against ANDV Induced Pathogenesis
    Erich R Mackow; Fiscal Year: 2013
    ..Andes virus (ANDV) infection results in acute pulmonary edema and respiratory insufficiency termed hantavirus pulmonary syndrome (HPS)...
  17. TASK Potassium Channel Antagonists to Treat Opioid Depression of Breathing
    Joseph F Cotten; Fiscal Year: 2013
    ....
  18. PARP inhibitor therapy for septic shock
    Andrew Salzman; Fiscal Year: 2004
    ..insufficiency (PT, albumin, total protein), (d) renal insufficiency (BUN/Cr, CVVH, oliguria), and (e) respiratory insufficiency (PaO2/FiO2 ratio, days of mechanical ventilation)...
  19. Mechanical regulation of branching morphogenesis
    Celeste M Nelson; Fiscal Year: 2012
    ..within the thoracic cavity can disrupt branching and cause fetal pulmonary hypoplasia, a major cause of respiratory insufficiency of the newborn. It is unclear how mechanical stresses control or disrupt the branching program...
  20. MICROMECHANICS OF RESPIRATORY MUSCLES
    ALADIN BORIEK; Fiscal Year: 1999
    ..b>Respiratory insufficiency is the cause of death in many primary neuromuscular disorders...
  21. Focal Adhesion Kinase and FAK-related Non-kinase in Idiopathic Pulmonary Fibrosis
    Qiang Ding; Fiscal Year: 2010
    Idiopathic pulmonary fibrosis (IPF) is a chronic lung disorder resulting in progressive respiratory insufficiency and lung fibrosis with fatal outcome. The pathogenesis of IPF remains unclear...
  22. Paracorporeal Ambulatory Assist Lung
    William R Wagner; Fiscal Year: 2013
    ..term support can lead to barotrauma, volutrauma, and other iatrogenic injuries, further exacerbating the respiratory insufficiency. Extracorporeal membrane oxygenation (ECMO) can provide longer term respiratory support but is complex ..
  23. PARS inhibitor therapy for smoke inhalation
    Andrew Salzman; Fiscal Year: 2004
    ..and continued for 5 days, the critical period of smoke inhalation induced pulmonary inflammation and respiratory insufficiency. Three primary clinical endpoints will be evaluated: 1) PF ratio, 2) duration of mechanical ventilation, ..
  24. Neuroplasticity and the carotid body
    Estelle Gauda; Fiscal Year: 2009
    ..abstract_text> ..
  25. RESPIRATORY SYSTEM MECHANICS
    ALADIN BORIEK; Fiscal Year: 2002
    ..b>Respiratory insufficiency is the usual cause of death in many primary neuromuscular disorders...
  26. Female Sex Hormones and Spinal Injury
    David Fuller; Fiscal Year: 2006
    ..Thus, sex hormone therapy targeting respiratory insufficiency may combine generalized neuroprotective effects with effects specific to the phrenic motor system...
  27. Aging & Marrow Stem Cell Homing to the Lung in Emphysema
    David Welsh; Fiscal Year: 2003
    ..for years with steadily progressive suffocation, punctuated by increasingly frequent exacerbations of respiratory insufficiency. Emphysema is histologically defined as the destruction of alveolar walls without significant fibrosis...
  28. BIOLOGICAL DISPOSITION OF NARCOTIC ANALGESICS IN MAN
    CARL HUG; Fiscal Year: 1980
    ..to investigate the basis of interactions of narcotic analgesics with other drugs, and 4. to recommend modifications of dosage regimens in various disease states (e.g., drug and alcohol abuse, liver failure). ..
  29. THE ROLE OF VASCULAR ENDOTHELIAL GROWTH FACTOR IN HUMAN
    MICHAEL ACARREGUI; Fiscal Year: 2003
    Immaturity of the pulmonary capillary bed is partly responsible for the respiratory insufficiency experienced by many prematurely born infants...
  30. DEPRESSION AND END OF LIFE CARE IN ALS
    Steven Albert; Fiscal Year: 2003
    ..lateral sclerosis (ALS) is a progressive neurodegenerative disease that results in death, usually from respiratory insufficiency or aspiration, within 3 to 5 years of diagnosis...
  31. EARLY INTERSTITIAL LUNG WATER CHANGES IN ACUTE TRAUMA
    John Miller; Fiscal Year: 1980
    ..Using a dog model we plan to assess early stages of acute respiratory insufficiency caused by a wide spectrum of clinically appropriate etiologies: prolonged general anesthesia; fluid ..
  32. MICROWAVE DEVICE FOR BLOOD WARMING & TEMPERATURE CONTROL
    RICHARD GRABOWY; Fiscal Year: 1991
    It is estimated that almost 75,000 persons each year will die of acute respiratory insufficiency caused by lung disease alone...
  33. REGULATION OF INSULIN LIKE GROWTH FACTOR I
    Edward Chan; Fiscal Year: 2001
    ..The inexorable fibrosis is paralleled by a course of relentless respiratory insufficiency. As a group, treatment of patients with these disorders have been largely disappointing...
  34. Enhancement of Phrenic Long-Term Facilitation Following Intermittent Hypoxia
    MICHAEL SHAMAINE HOFFMAN; Fiscal Year: 2010
    ..to treat patients with severe ventilatory control disorders, such as obstructive sleep apnea and respiratory insufficiency in patients with spinal cord injury or neurodegenerative disease (e.g., ALS)...
  35. IMPROVEMENT IN REGIONAL VENTILATION-PERFUSION RESOLUTION
    Richard Mitchell; Fiscal Year: 1980
    ..It has proven to be clinically useful in the treatment of acute respiratory insufficiency. By extending the resolution of radioactive gas measurements, these methods help minimize the spatial ..
  36. Reducing Sedative Exposure in Ventilated ICU Patients
    Linda Chlan; Fiscal Year: 2009
    ..is the most frequently used advanced, life-supportive modality in intensive care units (ICUs) to treat respiratory insufficiency from a variety of causes...
  37. CONTROL OF BREATHING: INFLUENCES OF UPPER AIRWAY ORIGIN
    OOMMEN MATHEW; Fiscal Year: 1993
    ..These studies should provide new information on the processes involved in upper airway maintenance and may clarify our understanding of the pathophysiology of obstructive sleep apnea, neonatal apnea and sudden infant death syndrome...
  38. BIOMEDICAL KNOWLEDGE ENGINEERING IN CLINICAL MEDICINE
    John Osborn; Fiscal Year: 1980
    ..links the experience at The Institutes of Medical Sciences in biomedical engineering and management of respiratory insufficiency with expertise at Stanford University in research on the application of knowledge-based computer ..
  39. DYING AT HOME OF AIDS & CANCER: PREFERENCES & OUTCOMES
    Judith Rabkin; Fiscal Year: 2004
    ..The data collected in the preliminary study will be used in the full-scale study. ..
  40. Outcomes of Prolonged Mechanical Ventilation
    Shannon Carson; Fiscal Year: 2006
    ..In addition, these data will inform future cohort studies and randomized controlled trials designed to improve outcomes for this growing patient population. ..
  41. Surfactant protein variants in pediatric lung injury
    Neal Thomas; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  42. DHEA EFFECTS ON MOOD IN DEPRESSED HIV+ PATIENTS
    Judith Rabkin; Fiscal Year: 2003
    ..This will permit the investigators to assess potential underlying mechanisms for the putative therapeutic effects of DHEA on mood, libido, and body composition. ..
  43. Modafinil Treatment for Fatigue in HIV+ Patients
    Judith Rabkin; Fiscal Year: 2008
    ..The major aims concern modafinil efficacy for fatigue compared to placebo, safety in terms of effects on immunologic/virologic measures, and impact on depressive symptoms when present at baseline. ..
  44. INTEGRATIVE NEUROBIOLOGY OF ALCOHOL WITHDRAWAL SEIZURES
    Carl Faingold; Fiscal Year: 2002
    ..We expect these approaches to yield novel insights into the neurobiological mechanisms controlling seizure susceptibility during ethanol withdrawal and suggest improved approaches to the therapy of alcoholism. ..
  45. Aerosolized PGE1 in Neonatal Pulmonary Hypertension
    BEENA SOOD; Fiscal Year: 2005
    ..If effective, a proposal for using aerosolized PGE1 in neonatal PPHN as a multicenter study will be submitted to the NICHD Neonatal Network. ..
  46. Transcranial Magnetic Stimulation and Neuromodulation
    Jau Shin Lou; Fiscal Year: 2003
    ..The results will provide us with vital information that will allow us to further develop rTMS as a noninvasive therapeutic modality for PD. ..
  47. PECAM-1'S INVOLVEMENT IN ANGIOGENESIS
    Horace Delisser; Fiscal Year: 2002
    ....
  48. MECHANICAL VENTILATION AND RESPIRATORY MUSCLES
    Scott Powers; Fiscal Year: 2004
    ..The long-term goal of our experiments is to provide the knowledge required to develop clinical strategies to oppose the deleterious effects of MV on respiratory muscles. ..
  49. Pathogenesis and Therapy of Marfan Vascular Disease
    Daniel Judge; Fiscal Year: 2007
    ..Dr. Judge's training will be based in the School of Public Health at Johns Hopkins, and he will be advised by a committee of experts to create a fruitful environment for the development of an independent clinical scientist. ..
  50. PLASTICITY OF SPINAL RESPIRATORY SYNAPTIC TRANSMISSION
    Stephen Johnson; Fiscal Year: 2001
    ....
  51. Graduate Medical Education in Genetics
    Margaret McGovern; Fiscal Year: 2004
    ..abstract_text> ..
  52. MAGNESIUM SULFATE FOR NEUROPROTECTION AFTER BRAIN TRAUMA
    Nancy Temkin; Fiscal Year: 2004
    ..abstract_text> ..
  53. Pheresis Treatment of Bioterrorism-Induced Sepsis
    Stephen Ash; Fiscal Year: 2005
    ..The safety systems of the existing PF system will be modified to meet the needs of the stand-alone system. Finally, an animal model of sepsis will be used to check efficacy and safety of the entire system. ..
  54. Effectiveness of Alcohol Interventions Among TB Patients in Tomsk, Russia
    Sonya Shin; Fiscal Year: 2008
    ..Finally, we have a diverse interdisciplinary team that has been able to formulate an integrated biosocial and culturally-appropriate approach to treating AUDs in this population. [unreadable] [unreadable] [unreadable]..
  55. FOURTH INTERNATIONAL CONFERENCE ON PEDIATRIC CARDIAC DEVICES
    Akif Undar; Fiscal Year: 2008
    ..This will be the only national/international conference to focus solely on pediatric cardiac patients. (End of Abstract) [unreadable] [unreadable] [unreadable]..
  56. Respiratory Muscle Training in Ventilator Dependent Pts.
    ANATOLE MARTIN; Fiscal Year: 2008
    ..This study will illuminate the mechanisms mediating MV dependence in these patients and lead to effective treatment strategies for patients dependent upon MV due to respiratory muscle weakness. [unreadable] [unreadable]..
  57. Proteasome Regulation of Interleukin-5 Receptor Endocytosis
    MAGARITA MARTINEZ MOCZYGEMBA; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  58. ROLE OF SURFACTANT PROTEIN D IN SURFACTANT HOMEOSTASIS
    Machiko Ikegami; Fiscal Year: 2006
    ..The intended studies will provide fundamental insights into the role of SP-D in the protection of the lung, as well as into the basic mechanisms determining surfactant homeostasis. ..
  59. Pulmonary Alveolar Proteinosis Research Conference
    Bruce Trapnell; Fiscal Year: 2005
    ..This conference will provide a forum where thought leaders focused on the molecular and cellular basis or clinical management of PAP will present cutting edge research, integrate concepts, and chart innovative research directions. ..
  60. Regulation of Alveolar Macrophage Phagocytosis
    Bruce Trapnell; Fiscal Year: 2006
    ..1, and Hck/SFKs in AMs. Results of this research are expected to help establish the feasibility of the therapeutic use of GM-CSF in the treatment of lung infections by a wide variety of microbial pathogens. ..
  61. Vascular Permeability Normalization in Ischemic Stroke
    DAVID EIZNHAMER; Fiscal Year: 2005
    ..Evans blue dye extravasation and brain water content will be the outcome measurements employed as direct indicators of the reduction or prevention of cerebral ischemic injury. ..
  62. Time-Dependent Changes in Respiratory Control After Perinatal Hyperoxia
    RYAN BAVIS; Fiscal Year: 2008
    ..Therefore, it is critical to understand how environmental conditions in early life influence development of protective chemoreflexes. [unreadable] [unreadable] [unreadable]..