dyspnea

Summary

Summary: Difficult or labored breathing.

Top Publications

  1. ncbi Evidence-based interventions to improve the palliative care of pain, dyspnea, and depression at the end of life: a clinical practice guideline from the American College of Physicians
    Amir Qaseem
    American College of Physicians, Philadelphia, Pennsylvania 19106, USA
    Ann Intern Med 148:141-6. 2008
  2. ncbi The body-mass index, airflow obstruction, dyspnea, and exercise capacity index in chronic obstructive pulmonary disease
    Bartolome R Celli
    COPD Center at St Elizabeth s Medical Center, Tufts University School of Medicine, Boston, MA 02135, USA
    N Engl J Med 350:1005-12. 2004
  3. doi Once-daily bronchodilators for chronic obstructive pulmonary disease: indacaterol versus tiotropium
    James F Donohue
    University of North Carolina, 4125 Bioinformatics Building, 130 Mason Farm Road, CB 7020, Chapel Hill, NC, USA
    Am J Respir Crit Care Med 182:155-62. 2010
  4. doi Once-daily indacaterol versus twice-daily salmeterol for COPD: a placebo-controlled comparison
    O Kornmann
    Pulmonary Division, Internal Medicine, University Hospital, Mainz, Germany
    Eur Respir J 37:273-9. 2011
  5. doi Physical activity in patients with COPD
    H Watz
    Pulmonary Research Institute Hospital Grosshansdorf, Center for Pneumology and Thoracic Surgery, Woehrendamm 80, Grosshansdorf, Germany
    Eur Respir J 33:262-72. 2009
  6. doi Expansion of the prognostic assessment of patients with chronic obstructive pulmonary disease: the updated BODE index and the ADO index
    Milo A Puhan
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Lancet 374:704-11. 2009
  7. doi Indacaterol add-on therapy improves lung function, exercise capacity and life quality of COPD patients
    R M Mroz
    Department of Lung Diseases, Medical University of Bialystok, Zurawia 14, Bialystok, Poland
    Adv Exp Med Biol 756:23-8. 2013
  8. ncbi Hyperinflation, dyspnea, and exercise intolerance in chronic obstructive pulmonary disease
    Denis E O'Donnell
    Department of Medicine, Queen s University, Kingston, Ontario, Canada
    Proc Am Thorac Soc 3:180-4. 2006
  9. ncbi Predictors of success and failure in pulmonary rehabilitation
    R Garrod
    School of Physiotherapy, Faculty of Health and Social Care Sciences, St George s, University of London, UK
    Eur Respir J 27:788-94. 2006
  10. ncbi Minimal important difference of the transition dyspnoea index in a multinational clinical trial
    T J Witek
    Respiratory Development and Operations, Boehringer Ingelheim GmbH Ingelheim am Rhein, Germany
    Eur Respir J 21:267-72. 2003

Detail Information

Publications416 found, 100 shown here

  1. ncbi Evidence-based interventions to improve the palliative care of pain, dyspnea, and depression at the end of life: a clinical practice guideline from the American College of Physicians
    Amir Qaseem
    American College of Physicians, Philadelphia, Pennsylvania 19106, USA
    Ann Intern Med 148:141-6. 2008
    ..1: In patients with serious illness at the end of life, clinicians should regularly assess patients for pain, dyspnea, and depression. (Grade: strong recommendation, moderate quality of evidence...
  2. ncbi The body-mass index, airflow obstruction, dyspnea, and exercise capacity index in chronic obstructive pulmonary disease
    Bartolome R Celli
    COPD Center at St Elizabeth s Medical Center, Tufts University School of Medicine, Boston, MA 02135, USA
    N Engl J Med 350:1005-12. 2004
    ..We hypothesized that a multidimensional grading system that assessed the respiratory and systemic expressions of COPD would better categorize and predict outcome in these patients...
  3. doi Once-daily bronchodilators for chronic obstructive pulmonary disease: indacaterol versus tiotropium
    James F Donohue
    University of North Carolina, 4125 Bioinformatics Building, 130 Mason Farm Road, CB 7020, Chapel Hill, NC, USA
    Am J Respir Crit Care Med 182:155-62. 2010
    ..Indacaterol is the first once-daily, long-acting inhaled beta(2)-agonist bronchodilator studied in patients with chronic obstructive pulmonary disease (COPD)...
  4. doi Once-daily indacaterol versus twice-daily salmeterol for COPD: a placebo-controlled comparison
    O Kornmann
    Pulmonary Division, Internal Medicine, University Hospital, Mainz, Germany
    Eur Respir J 37:273-9. 2011
    ..Indacaterol should prove a useful additional treatment for patients with COPD...
  5. doi Physical activity in patients with COPD
    H Watz
    Pulmonary Research Institute Hospital Grosshansdorf, Center for Pneumology and Thoracic Surgery, Woehrendamm 80, Grosshansdorf, Germany
    Eur Respir J 33:262-72. 2009
    ..Clinical characteristics of patients with chronic obstructive pulmonary disease only incompletely reflect their physical activity...
  6. doi Expansion of the prognostic assessment of patients with chronic obstructive pulmonary disease: the updated BODE index and the ADO index
    Milo A Puhan
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Lancet 374:704-11. 2009
    ..We assessed the calibration of the BODE index, updated it to improve its calibration, and developed and validated a simplified index for use in primary-care settings...
  7. doi Indacaterol add-on therapy improves lung function, exercise capacity and life quality of COPD patients
    R M Mroz
    Department of Lung Diseases, Medical University of Bialystok, Zurawia 14, Bialystok, Poland
    Adv Exp Med Biol 756:23-8. 2013
    ..The disease leads to airflow limitation, and pulmonary hyperinflation, resulting in dyspnea, decreased exercise tolerance, and impaired quality of life...
  8. ncbi Hyperinflation, dyspnea, and exercise intolerance in chronic obstructive pulmonary disease
    Denis E O'Donnell
    Department of Medicine, Queen s University, Kingston, Ontario, Canada
    Proc Am Thorac Soc 3:180-4. 2006
    Expiratory flow limitation is the pathophysiologic hallmark of chronic obstructive pulmonary disease (COPD), but dyspnea (breathlessness) is its most prominent and distressing symptom...
  9. ncbi Predictors of success and failure in pulmonary rehabilitation
    R Garrod
    School of Physiotherapy, Faculty of Health and Social Care Sciences, St George s, University of London, UK
    Eur Respir J 27:788-94. 2006
    ..Risk of drop-out is significantly greater in depressed compared with nondepressed patients...
  10. ncbi Minimal important difference of the transition dyspnoea index in a multinational clinical trial
    T J Witek
    Respiratory Development and Operations, Boehringer Ingelheim GmbH Ingelheim am Rhein, Germany
    Eur Respir J 21:267-72. 2003
    ....
  11. doi The major limitation to exercise performance in COPD is dynamic hyperinflation
    Denis E O'Donnell
    Department of Medicine, Queen s University, Kingston, Ontario, Canada
    J Appl Physiol 105:753-5; discussion 755-7. 2008
  12. pmc Indacaterol on dyspnea in chronic obstructive pulmonary disease: a systematic review and meta-analysis of randomized placebo-controlled trials
    Jiangna Han
    Department of Pneumology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China
    BMC Pulm Med 13:26. 2013
    ..The aim of this study was to evaluate the efficacy of indacaterol on dyspnea, using available randomized placebo-controlled trials.
  13. doi Effect of an indwelling pleural catheter vs chest tube and talc pleurodesis for relieving dyspnea in patients with malignant pleural effusion: the TIME2 randomized controlled trial
    Helen E Davies
    Department of Respiratory Medicine, University Hospital of Wales, Cardiff, Wales
    JAMA 307:2383-9. 2012
    Malignant pleural effusion causes disabling dyspnea in patients with a short life expectancy. Palliation is achieved by fluid drainage, but the most effective first-line method has not been determined.
  14. pmc Internet-based dyspnea self-management support for patients with chronic obstructive pulmonary disease
    Huong Q Nguyen
    University of Washington, Seattle, Washington, USA
    J Pain Symptom Manage 46:43-55. 2013
    People with chronic obstructive pulmonary disease experience dyspnea with activities despite optimal medical management.
  15. ncbi Exercise training improves exertional dyspnea in patients with COPD: evidence of the role of mechanical factors
    Francesco Gigliotti
    Fondazione Don C Gnocchi, IRCCS, Pozzolatico, Firenze
    Chest 123:1794-802. 2003
    ..output or neuromuscular coupling (NMC) of the ventilatory pump, and their potential association with exertional dyspnea. Accurate assessment of these important clinical outcomes is integral to effective management of breathlessness ..
  16. pmc Dyspnea severity, changes in dyspnea status and mortality in the general population: the Vlagtwedde/Vlaardingen study
    Sylwia M Figarska
    Department of Epidemiology, University Medical Center Groningen, University of Groningen, Hanzeplein 1, P O Box 30001, 9700 RB, Groningen, The Netherlands
    Eur J Epidemiol 27:867-76. 2012
    b>Dyspnea is a predictor of mortality. The effects of dyspnea severity and changes in dyspnea status on all-cause and cause-specific mortality remain unclear...
  17. pmc Outcome measures in chronic obstructive pulmonary disease (COPD): strengths and limitations
    Thomas Glaab
    Pulmonary Department, University Hospital, Johannes Gutenberg University, Mainz, Germany
    Respir Res 11:79. 2010
    ....
  18. doi Evolution of dyspnea during exercise in chronic obstructive pulmonary disease: impact of critical volume constraints
    Pierantonio Laveneziana
    Respiratory Investigation Unit, Department of Medicine, Queen s University, Kingston, Ontario, Canada
    Am J Respir Crit Care Med 184:1367-73. 2011
    Patients with chronic obstructive pulmonary disease (COPD) primarily describe their exertional dyspnea using descriptors alluding to increased effort or work of breathing and unsatisfied inspiration or inspiratory difficulty.
  19. ncbi Mortality after hospitalization for COPD
    Pedro Almagro
    Internal Medicine, Hospital Mutua de Terrassa, University of Barcelona, Barcelona, Spain
    Chest 121:1441-8. 2002
    ..To identify variables associated with mortality in patients admitted to the hospital for acute exacerbation of COPD...
  20. pmc Health-related quality of life is related to COPD disease severity
    Elisabeth Stahl
    Department of Respiratory Medicine and Allergology, University Hospital, SE 221 85 Lund, Sweden
    Health Qual Life Outcomes 3:56. 2005
    ..The aim of this study was to evaluate the association between health-related quality of life (HRQL) and disease severity using lung function measures...
  21. ncbi Dyspnea is a better predictor of 5-year survival than airway obstruction in patients with COPD
    Koichi Nishimura
    Respiratory Division, Kyoto Katsura Hospital, Kyoto, Japan
    Chest 121:1434-40. 2002
    ..Recently, however, the categorization of patients with COPD on the basis of the level of dyspnea has similarly been reported to be useful in the prediction of health-related quality of life and improvement in ..
  22. doi Effects of pulmonary rehabilitation in patients with idiopathic pulmonary fibrosis
    Osamu Nishiyama
    Department of Respiratory Medicine and Allergy, Tosei General Hospital, Seto Aichi, Japan
    Respirology 13:394-9. 2008
    ..Although pulmonary rehabilitation is effective for patients with COPD, its efficacy in patients with IPF is unknown. The purpose of this study was to evaluate the effects of pulmonary rehabilitation in IPF...
  23. pmc Randomized controlled trial of an internet-based versus face-to-face dyspnea self-management program for patients with chronic obstructive pulmonary disease: pilot study
    Huong Q Nguyen
    Biobehavioral Nursing and Health Systems, University of Washington, Box 357266, Seattle, WA 98199, USA
    J Med Internet Res 10:e9. 2008
    People with chronic obstructive pulmonary disease (COPD) continue to experience dyspnea with activities of daily living (ADL) despite optimal medical management...
  24. ncbi Is Internet-based support for dyspnea self-management in patients with chronic obstructive pulmonary disease possible? Results of a pilot study
    Huong Q Nguyen
    Biobehavioral Nursing and Health Systems, University of Washington, Seattle 98195 7266, USA
    Heart Lung 34:51-62. 2005
    ..The purpose of this study was to determine the feasibility and preliminary efficacy of an Internet-based dyspnea self-management program (iDSMP) for people with chronic obstructive pulmonary disease...
  25. ncbi Effect of heliox on lung dynamic hyperinflation, dyspnea, and exercise endurance capacity in COPD patients
    Paolo Palange
    Dipartimento di Medicina Clinica, Servizio di Fisiopatologia Respiratoria, Universita La Sapienza, v le Universita 37, 00185 Rome, Italy
    J Appl Physiol (1985) 97:1637-42. 2004
    We tested the hypothesis that heliox breathing, by reducing lung dynamic hyperinflation (DH) and dyspnea (Dys) sensation, may significantly improve exercise endurance capacity in patients with chronic obstructive pulmonary disease [n = ..
  26. ncbi Dyspnea and activity limitation in COPD: mechanical factors
    Denis E O'Donnell
    Division of Respiratory and Critical Care Medicine, Department of Medicine, Queen s University, Kingston, Ontario, Canada
    COPD 4:225-36. 2007
    b>Dyspnea and activity limitation are the primary symptoms of chronic obstructive pulmonary disease and progress relentlessly as the disease advances...
  27. ncbi The N-terminal Pro-BNP investigation of dyspnea in the emergency department (PRIDE) study
    James L Januzzi
    Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    Am J Cardiol 95:948-54. 2005
    ..We conducted a prospective study of 600 patients who presented in the emergency department with dyspnea. The clinical diagnosis of acute CHF was determined by study physicians who were blinded to NT-proBNP results...
  28. ncbi Exertional breathlessness in patients with chronic airflow limitation. The role of lung hyperinflation
    D E O'Donnell
    Department of Medicine, Queen s University, Kingston, Ontario, Canada
    Am Rev Respir Dis 148:1351-7. 1993
    ..to this variability we compared breathing pattern parameters, dynamic operational lung volumes, and Borg dyspnea ratings in 23 patients with severe CAL and in 10 healthy age-matched normal subjects during cycle ergometry to ..
  29. ncbi Use of B-type natriuretic peptide in the evaluation and management of acute dyspnea
    Christian Mueller
    Department of Internal Medicine, Medical Division A, University of Basel, University Hospital, Basel, Switzerland
    N Engl J Med 350:647-54. 2004
    B-type natriuretic peptide levels are higher in patients with congestive heart failure than in patients with dyspnea from other causes.
  30. doi Effect of nesiritide in patients with acute decompensated heart failure
    C M O'Connor
    Duke Clinical Research Institute, Duke University Medical Center, Durham, North Carolina 27710, USA
    N Engl J Med 365:32-43. 2011
    Nesiritide is approved in the United States for early relief of dyspnea in patients with acute heart failure. Previous meta-analyses have raised questions regarding renal toxicity and the mortality associated with this agent.
  31. doi Combined effects of obesity and chronic obstructive pulmonary disease on dyspnea and exercise tolerance
    Josuel Ora
    Respiratory Investigation Unit, Department of Medicine, Queen s University and Kingston General Hospital, Kingston, Ontario, Canada
    Am J Respir Crit Care Med 180:964-71. 2009
    Severity of lung hyperinflation is known to influence the extent of dyspnea and exercise intolerance among patients with chronic obstructive pulmonary disease (COPD) with similar degrees of airway obstruction...
  32. doi Inspiratory muscle training in adults with chronic obstructive pulmonary disease: an update of a systematic review
    E Lynne Geddes
    School of Rehabilitation Science, Institute of Applied Health Science, Room 403, McMaster University, 1400 Main Street West, Hamilton, ON, Canada L8S 1C7
    Respir Med 102:1715-29. 2008
    ..the effect of inspiratory muscle training (IMT) on inspiratory muscle strength and endurance, exercise capacity, dyspnea and quality of life for adults with chronic obstructive pulmonary disease (COPD)...
  33. pmc Development of a self-reported Chronic Respiratory Questionnaire (CRQ-SR)
    J E Williams
    Department of Respiratory Medicine, University Hospitals of Leicester, Glenfield Hospital, Leicester LE3 9QP, UK
    Thorax 56:954-9. 2001
    ..A study was undertaken to develop a self-reported version of the CRQ (CRQ-SR) and to compare the results of this questionnaire with the conventional interviewer led CRQ (CRQ-IL)...
  34. doi Mid-region pro-hormone markers for diagnosis and prognosis in acute dyspnea: results from the BACH (Biomarkers in Acute Heart Failure) trial
    Alan Maisel
    VA San Diego Healthcare System, San Diego, California 92161, USA
    J Am Coll Cardiol 55:2062-76. 2010
    ....
  35. doi Sex differences in exertional dyspnea in patients with mild COPD: physiological mechanisms
    Jordan A Guenette
    Respiratory Investigation Unit, Department of Medicine, Queen s University and Kingston General Hospital, Kingston, ON, Canada
    Respir Physiol Neurobiol 177:218-27. 2011
    The purpose of this study was to evaluate the physiological basis for sex-differences in exercise-induced dyspnea in patients with mild COPD...
  36. ncbi The effects of short-term and long-term pulmonary rehabilitation on functional capacity, perceived dyspnea, and quality of life
    David Verrill
    NorthEast Medical Center Clinical Research Institute, Concord, NC, USA
    Chest 128:673-83. 2005
    The purposes of this study were as follows: (1) to determine whether physical performance, quality of life, and dyspnea with activities of daily living improved following both short-term and long-term pulmonary rehabilitation (PR) across ..
  37. doi Short term improvement in exercise capacity and symptoms following exercise training in interstitial lung disease
    A E Holland
    Physiotherapy Department, Alfred Hospital, Commercial Rd, Melbourne, Australia 3004
    Thorax 63:549-54. 2008
    ....
  38. pmc Gender and respiratory factors associated with dyspnea in chronic obstructive pulmonary disease
    Juan P de Torres
    Respiratory Research Unit, Hospital Nuestra Sra de Candelaria, Tenerife, Spain
    Respir Res 8:18. 2007
    We had shown that COPD women expressed more dyspnea than men for the same degree of airway obstruction.
  39. ncbi Obesity is a risk factor for dyspnea but not for airflow obstruction
    Don D Sin
    Department of Medicine, University of Alberta, Edmonton, Canada T6G 2B7
    Arch Intern Med 162:1477-81. 2002
    Previous research suggests that obesity is an important risk factor for asthma. However, since obesity can cause dyspnea through mechanisms other than airflow obstruction, diagnostic misclassification of asthma could partially account ..
  40. doi Activation of the prefrontal cortex is associated with exertional dyspnea in chronic obstructive pulmonary disease
    Yuji Higashimoto
    Department of Rehabilitation Medicine, Kinki University, Faculty of Medicine, Osaka, Japan
    Respiration 82:492-500. 2011
    Exertional dyspnea is the primary symptom that limits exercise in patients with chronic obstructive pulmonary disease (COPD). It is unknown which activated brain area is associated with this symptom in COPD patients.
  41. doi Impact of pulmonary hypertension on gas exchange and exercise capacity in patients with pulmonary fibrosis
    Sven Glaser
    Division of Pulmonary Medicine and Infectious Diseases, University of Greifswald, Sauerbruchstrasse, 17475 Greifswald, Germany
    Respir Med 103:317-24. 2009
    ..The further impairment of exercise capacity as well as the extent of dyspnoea in patients with interceding PHT is attributable to a significantly impaired ventilatory inefficiency...
  42. doi Comparison of acute transient dyspnea after intravenous administration of gadoxetate disodium and gadobenate dimeglumine: effect on arterial phase image quality
    Matthew S Davenport
    Department of Radiology University of Michigan Health System, 1500 E Medical Center Dr, B2 A209P, Ann Arbor, MI 48109, USA
    Radiology 266:452-61. 2013
    To determine whether acute transient dyspnea and/or arterial phase image degradation occurs more or less often after intravenous administration of gadoxetate disodium than with intravenous administration of gadobenate dimeglumine.
  43. ncbi Pathophysiology of dyspnea in chronic obstructive pulmonary disease: a roundtable
    Denis E O'Donnell
    Department of Medicine, Queen s University, 102 Stuart Street, Kingston, ON, K7L 2V6 Canada
    Proc Am Thorac Soc 4:145-68. 2007
    Effective management of dyspnea in chronic obstructive pulmonary disease (COPD) requires a clearer understanding of its underlying mechanisms...
  44. ncbi The MCID of the transition dyspnea index is a total score of one unit
    Donald A Mahler
    Dartmouth Medical School, Lebanon, New Hampshire 03656 0001, USA
    COPD 2:99-103. 2005
    The Baseline (BDI) and Transition (TDI) Dyspnea Indexes provide interview-based measurements of breathlessness related to activities of daily living...
  45. pmc Differences in classification of COPD group using COPD assessment test (CAT) or modified Medical Research Council (mMRC) dyspnea scores: a cross-sectional analyses
    SunMin Kim
    Division of Pulmonology, Department of Internal Medicine, Chonnam National University Hospital, 42 Jebong ro, Donggu 501 757, Gwangju, South Korea
    BMC Pulm Med 13:35. 2013
    ..for COPD combining symptom assessment by COPD assessment test (CAT) or modified Medical Research Council (mMRC) dyspnea scores, and exacerbation risk...
  46. pmc Massive right atrial myxoma presenting as syncope and exertional dyspnea: case report
    Olga Azevedo
    Cardiology Department, Centro Hospitalar do Alto Ave Unidade de Guimarães, Guimaraes, Portugal
    Cardiovasc Ultrasound 8:23. 2010
    ..of a massive right atrial myxoma causing tricuspid valve obstruction and presenting as syncope and exertional dyspnea. This case illustrates the influence of myxoma's size, position and mobility as well as patient's body posture ..
  47. ncbi Ventilatory and perceptual responses to cycle exercise in obese women
    Dror Ofir
    Respiratory Investigation Unit, Department of Medicine, Queen s University, 102 Stuart St, Kingston, Ontario, Canada K7L 2V6
    J Appl Physiol 102:2217-26. 2007
    ....
  48. ncbi Utility of impedance cardiography to determine cardiac vs. noncardiac cause of dyspnea in the emergency department
    Charles L Springfield
    Aventura Hospital and Medical Center, Aventura, FL 33180, USA
    Congest Heart Fail 10:14-6. 2004
    Determining the correct diagnosis of patients with dyspnea can be challenging. Early and accurate determination of the cause of dyspnea is vital in instituting timely and appropriate interventions...
  49. doi Relationship between small airway function and health status, dyspnea and disease control in asthma
    Tomoshi Takeda
    Department of Respiratory Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    Respiration 80:120-6. 2010
    Small airways play important roles in the pathophysiology of asthma. However, relationships between small airway involvement and health status and dyspnea have not been investigated.
  50. pmc Predictors of chronic breathlessness: a large population study
    Jacqueline A Bowden
    Cancer Council, South Australia, 202 Greenhill Rd, Parkside, South Australia, Australia
    BMC Public Health 11:33. 2011
    ..This study aims to define these predictors of chronic breathlessness at a population level...
  51. ncbi Measurement of symptoms, lung hyperinflation, and endurance during exercise in chronic obstructive pulmonary disease
    D E O'Donnell
    Respiratory Investigation Unit, Departments of Medicine, and Community Health and Epidemiology, Queen s University, Kingston, Ontario, Canada
    Am J Respir Crit Care Med 158:1557-65. 1998
    Changes in lung hyperinflation, dyspnea, and exercise endurance are important outcomes in assessing therapeutic responses in chronic obstructive pulmonary disease (COPD)...
  52. doi Task-related oxygen uptake during domestic activities of daily life in patients with COPD and healthy elderly subjects
    Anouk W Vaes
    Program Development Centre, CIRO, Horn, The Netherlands
    Chest 140:970-9. 2011
    ..with COPD after stratification for sex; GOLD (Global Initiative for Chronic Obstructive Lung Disease) stage; Medical Research Council (MRC) dyspnea grade; or score on the BMI, obstruction, dyspnea, exercise capacity (BODE) index.
  53. doi High value of combined serum C-reactive protein and BODE score for mortality prediction in patients with stable COPD
    Shih Feng Liu
    Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Chang Gung Memorial Hospital, Kaohsiung Medical Center, Taiwan, China
    Arch Bronconeumol 47:427-32. 2011
    Both BODE score (body mass index, degree of airflow obstruction, functional dyspnea, and exercise capacity) and serum C-reactive protein (CRP) are validated predictors of mortality in patients with chronic obstructive pulmonary disease (..
  54. doi Effect of obesity on respiratory mechanics during rest and exercise in COPD
    Josuel Ora
    Respiratory Investigation Unit, Department of Medicine, Queen s University and Kingston General Hospital, Kingston, Ontario, Canada
    J Appl Physiol (1985) 111:10-9. 2011
    The presence of obesity in COPD appears not to be a disadvantage with respect to dyspnea and weight-supported cycle exercise performance...
  55. doi Gender differences in perception of dyspnea, assessment of control, and quality of life in asthma
    Sunil K Chhabra
    Department of Cardiorespiratory Physiology, Vallabhbhai Patel Chest Institute, Clinical Research Centre, University of Delhi, Delhi 110007, India
    J Asthma 48:609-15. 2011
    ..There is limited information on the inter-relationship between gender, perception of dyspnoea and health-related quality of life (HRQoL) in asthma...
  56. doi Emergency thoracic ultrasound in the differentiation of the etiology of shortness of breath (ETUDES): sonographic B-lines and N-terminal pro-brain-type natriuretic peptide in diagnosing congestive heart failure
    Andrew S Liteplo
    Department of Emergency Medicine, Division of Emergency Ultrasound, Massachusetts General Hospital, Boston, MA, USA
    Acad Emerg Med 16:201-10. 2009
    ..They also sought to determine optimal two- and eight-zone scanning protocols when different thresholds for a positive scan were used...
  57. doi Quality of COPD care in hospital outpatient clinics in Denmark: The KOLIBRI study
    Peter Lange
    Department of Cardiology and Respiratory Medicine, Hvidovre Hospital, Denmark
    Respir Med 103:1657-62. 2009
    ....
  58. ncbi Measurement of the interleukin family member ST2 in patients with acute dyspnea: results from the PRIDE (Pro-Brain Natriuretic Peptide Investigation of Dyspnea in the Emergency Department) study
    James L Januzzi
    Department of Medicine and Laboratory Medicine, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Am Coll Cardiol 50:607-13. 2007
    The aim of this study was to examine the value of measurement of the interleukin-1 receptor family member ST2 in patients with dyspnea.
  59. doi Evidence-based recommendations for cancer fatigue, anorexia, depression, and dyspnea
    Sydney M Dy
    Health Policy and Management, Oncology, and Medicine, Johns Hopkins University, Baltimore, MD 21205, USA
    J Clin Oncol 26:3886-95. 2008
    PURPOSE The experience of patients with cancer often involves symptoms of fatigue, anorexia, depression, and dyspnea. METHODS We developed a set of standards through an iterative process of structured literature review and development ..
  60. doi Ticagrelor versus clopidogrel in patients with acute coronary syndromes
    Lars Wallentin
    Uppsala Clinical Research Center, Uppsala, Sweden
    N Engl J Med 361:1045-57. 2009
    ..Ticagrelor is an oral, reversible, direct-acting inhibitor of the adenosine diphosphate receptor P2Y12 that has a more rapid onset and more pronounced platelet inhibition than clopidogrel...
  61. ncbi Ventilatory limitations in chronic obstructive pulmonary disease
    D E O'Donnell
    Department of Medicine, Division of Respiratory and Critical Care Medicine, Queen s University, Kingston, Ontario, Canada
    Med Sci Sports Exerc 33:S647-55. 2001
    ....
  62. doi Combining tiotropium and salmeterol in COPD: Effects on airflow obstruction and symptoms
    J A Van Noord
    Department of Respiratory Diseases, Atrium Medisch Centrum, Henri Dunantstraat 5, 6419 PC Heerlen, The Netherlands
    Respir Med 104:995-1004. 2010
    ..Clinical information on 24-h spirometric efficacy of combining tiotropium and salmeterol compared to single-agent therapy is lacking in patients with COPD...
  63. doi Symptom variability in patients with severe COPD: a pan-European cross-sectional study
    R Kessler
    Dept of PneumologyNouvel Hôpital Civil, Strasbourg 67000, France
    Eur Respir J 37:264-72. 2011
    ..Patient-perceived COPD symptoms vary over the day and the week, and impact on daily activities; morning being the worst time of day. The majority of patients appear not to adjust treatment when symptoms worsen...
  64. doi Six-minute-walk test in idiopathic pulmonary fibrosis: test validation and minimal clinically important difference
    Roland M du Bois
    National Heart and Lung Institute, Imperial College, London, United Kingdom
    Am J Respir Crit Care Med 183:1231-7. 2011
    ..Performance characteristics in patients with idiopathic pulmonary fibrosis (IPF) have not been systematically evaluated...
  65. ncbi Respiratory symptoms, COPD severity, and health related quality of life in a general population sample
    Marianne Voll-Aanerud
    Department of Thoracic Medicine, Haukeland University Hospital, Jonas Lies vei 65, N5021 Bergen, Norway
    Respir Med 102:399-406. 2008
    ..The aim of this report from a general population sample was to examine the association of respiratory symptoms and COPD severity with HRQoL (health related quality of life)...
  66. ncbi Validation of the Modified Pulmonary Functional Status and Dyspnea Questionnaire and the Medical Research Council scale for use in Brazilian patients with chronic obstructive pulmonary disease
    Demetria Kovelis
    Laboratorio de Pesquisa em Fisioterapia Pulmonar, Departamento de Fisioterapia, Centro de Ciencias da Saude, Hospital Universitario Regional Norte do Parana, Universidade Estadual de Londrina, Londrina, PR, Brasil
    J Bras Pneumol 34:1008-18. 2008
    ..of daily living (ADLs) in patients with chronic obstructive pulmonary disease (COPD) in Brazil: the Pulmonary Functional Status and Dyspnea Questionnaire - Modified version (PFSDQ-M) and the Medical Research Council (MRC) scale.
  67. doi Decline of resting inspiratory capacity in COPD: the impact on breathing pattern, dyspnea, and ventilatory capacity during exercise
    Denis E O'Donnell
    Department of Medicine, Queen sUniversity, Kingston, ON, Canada
    Chest 141:753-62. 2012
    To better understand the interrelationships among disease severity, inspiratory capacity (IC), breathing pattern, and dyspnea, we studied responses to symptom-limited cycle exercise in a large cohort with COPD.
  68. ncbi Physiological changes during symptom recovery from moderate exacerbations of COPD
    C M Parker
    102 Stuart Street, Kingston, Ontario, Canada
    Eur Respir J 26:420-8. 2005
    ..Improvement of dyspnoea following acute exacerbations of chronic obstructive pulmonary disease was associated with reduction in lung hyperinflation and consequent increase in expiratory flow rates...
  69. doi Determinants of poor 6-min walking distance in patients with COPD: the ECLIPSE cohort
    Martijn A Spruit
    Program Development Centre, CIRO, a centre of excellence for chronic organ failure, Horn, The Netherlands
    Respir Med 104:849-57. 2010
    ..We aimed to identify clinical determinants of a poor 6-min walking distance (<350 m) in patients with COPD...
  70. ncbi Effect of obesity on breathlessness and airway responsiveness to methacholine in non-asthmatic subjects
    C M Salome
    Woolcock Institute of Medical Research, Camperdown, New South Wales, Australia
    Int J Obes (Lond) 32:502-9. 2008
    ..Obesity reduces lung volumes, which can increase airway responsiveness, and increases resistive and elastic work of breathing, which can increase dyspnea.
  71. ncbi Renal function, congestive heart failure, and amino-terminal pro-brain natriuretic peptide measurement: results from the ProBNP Investigation of Dyspnea in the Emergency Department (PRIDE) Study
    Saif Anwaruddin
    Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    J Am Coll Cardiol 47:91-7. 2006
    ..the context of patients who presented to the emergency department of an urban tertiary care medical center with dyspnea. Even in the presence of renal insufficiency, NT-proBNP remained a valuable tool for the diagnosis of acute ..
  72. ncbi Improvement in quadriceps strength and dyspnea in daily tasks after 1 month of electrical stimulation in severely deconditioned and malnourished COPD
    Isabelle Vivodtzev
    Lung Function and Exercise Laboratory, Hospital A Michallon, Grenoble, France
    Chest 129:1540-8. 2006
    Low body weight in COPD patients is associated with worsening dyspnea, reduced leg strength, and poor prognosis. Classical rehabilitation strategies are then limited by reduced exercise tolerance...
  73. ncbi A comparison of the level of dyspnea vs disease severity in indicating the health-related quality of life of patients with COPD
    T Hajiro
    Department of Respiratory Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    Chest 116:1632-7. 1999
    To compare categorizations of the level of dyspnea with the staging of disease severity as defined by the FEV(1) in representing how the health-related quality of life (HRQOL) is distributed in patients with COPD.
  74. ncbi Effects of tiotropium on lung hyperinflation, dyspnoea and exercise tolerance in COPD
    D E O'Donnell
    Respiratory Investigation Unit, Dept of Medicine, Queen s University, Kingston, Ontario, Canada
    Eur Respir J 23:832-40. 2004
    ..Resultant increases in inspiratory capacity permitted greater expansion of tidal volume and contributed to improvements in both exertional dyspnoea and exercise endurance...
  75. ncbi Minimally clinically important difference for the UCSD Shortness of Breath Questionnaire, Borg Scale, and Visual Analog Scale
    Andrew L Ries
    University of California, UCSD Medical Center 200 W Arbor Drive, San Diego, California 92103 8377, USA
    COPD 2:105-10. 2005
    b>Dyspnea is a primary symptom of chronic lung disease and an important outcome measure for clinical trials...
  76. ncbi Utility of a rapid B-natriuretic peptide assay in differentiating congestive heart failure from lung disease in patients presenting with dyspnea
    L Katherine Morrison
    Division of Cardiology, Veteran s Affairs Medical Center, San Diego, California 92161, USA
    J Am Coll Cardiol 39:202-9. 2002
    ..B-type natriuretic peptide (BNP) is secreted by the left ventricle (LV) in response to volume elevated LV pressure, we sought to assess whether a rapid assay for BNP levels could differentiate cardiac from pulmonary causes of dyspnea.
  77. ncbi The risk of hospitalization and near-fatal and fatal asthma in relation to the perception of dyspnea
    Rasmi Magadle
    Department of Medicine A, Hillel Yaffe, Medical Center, Hadera, Israel
    Chest 121:329-33. 2002
    ..It has been shown that patients who have a near-fatal asthma attack have a blunted perception of dyspnea (POD)...
  78. ncbi A comparison of the reproducibility and the sensitivity to change of visual analogue scales, Borg scales, and Likert scales in normal subjects during submaximal exercise
    S Grant
    Centre for Exercise Science and Medicine, Institute of Biomedical and Life Sciences, University of Glasgow, UK
    Chest 116:1208-17. 1999
    ..To assess which subjective scale, the visual analogue scale (VAS), the Borg CR10 (Borg) scale, or the Likert scale (LS), if any, is decidedly more reproducible and sensitive to change in the assessment of symptoms...
  79. ncbi Breathlessness in cancer and chronic obstructive pulmonary disease: using a qualitative approach to describe the experience of patients and carers
    Sara Booth
    Oncology Centre, Addenbrooke s Hospital, Cambridge, UK
    Palliat Support Care 1:337-44. 2003
    ..This subject has been little researched, although dyspnoea is recognized as a disabling, distressing symptom. The number of breathless people is increasing as patients with all types of cardio-respiratory disease live longer...
  80. ncbi Exacerbations and lung function decline in COPD: new insights in current and ex-smokers
    D Makris
    Department of Thoracic Medicine, University of Crete, Medical School, 71110 Heraklion, Greece
    Respir Med 101:1305-12. 2007
    ..Spirometry was performed every 6 months. The effect of frequent exacerbations on lung function was investigated using random effects models...
  81. ncbi The Brazilian Portuguese version of the London Chest Activity of Daily Living scale for use in patients with chronic obstructive pulmonary disease
    Marta Fioravante Carpes
    Department of Physical Therapy, Universidade do Vale do Itajai UNIVALI, Vale do Itajaí University Itajaí, Brazil
    J Bras Pneumol 34:143-51. 2008
    ..To translate the London Chest Activity of Daily Living (LCADL) scale into Portuguese and to determine whether this version is reproducible in Brazilian patients with severe chronic obstructive pulmonary disease (COPD)...
  82. pmc Markers of decongestion, dyspnea relief, and clinical outcomes among patients hospitalized with acute heart failure
    Robb D Kociol
    Duke Clinical Research Institute, Durham, NC, USA
    Circ Heart Fail 6:240-5. 2013
    ....
  83. ncbi Gender differences in the management and experience of Chronic Obstructive Pulmonary Disease
    Louise Watson
    Department of Worldwide Epidemiology, GlaxoSmithKline, Greenford, UK
    Respir Med 98:1207-13. 2004
    ..After adjusting for age, pack-years, country and severe dyspnea (MRC scores 5 and 4), women were less likely to have had spirometry (OR 0.84, 95% C.I. 0.72-0...
  84. ncbi Profile of the level of physical activity in the daily lives of patients with COPD in Brazil
    Nidia Aparecida Hernandes
    Respiratory Therapy Research Laboratory, State University of Londrina, Londrina, Brazil
    J Bras Pneumol 35:949-56. 2009
    ..To evaluate characteristics of physical activities in daily life in COPD patients in Brazil, correlating those characteristics with physiological variables...
  85. pmc Effects of beclomethasone/formoterol fixed combination on lung hyperinflation and dyspnea in COPD patients
    Panagiota Tzani
    Department of Clinical Sciences, University of Parma, Parma, Italy
    Int J Chron Obstruct Pulmon Dis 6:503-9. 2011
    Chronic obstructive pulmonary disease (COPD) is a common disease characterized by airflow obstruction and lung hyperinflation leading to dyspnea and exercise capacity limitation.
  86. doi The impact of affective states on the perception of dyspnea in patients with chronic obstructive pulmonary disease
    Andreas von Leupoldt
    Department of Psychology, University of Hamburg, Hamburg, Germany
    Biol Psychol 84:129-34. 2010
    b>Dyspnea is the cardinal symptom of chronic obstructive pulmonary disease (COPD). Affective states can profoundly impact upon the perception of dyspnea, but little is known about this relationship in patients with COPD...
  87. ncbi Patient's perception of exacerbations of COPD--the PERCEIVE study
    Marc Miravitlles
    Servei de Pneumologia, Institut Clínic del Tòrax IDIBAPS, Hospital Clinic Barcelona, Spain
    Respir Med 101:453-60. 2007
    ..New data are provided on the impact of COPD and its exacerbations on the daily life of patients. These data will help to develop PROs designed to evaluate the effectiveness of different therapies for exacerbated COPD...
  88. doi Randomized controlled trial of mindfulness-based therapy for dyspnea in chronic obstructive lung disease
    Richard A Mularski
    The Center for Health Research, Kaiser Permanente Northwest, Portland, OR 97227, USA
    J Altern Complement Med 15:1083-90. 2009
    Patients with chronic obstructive lung disease (COPD) suffer from significant dyspnea and may benefit from complementary and alternative medicine (CAM) therapies aimed at mitigating symptoms...
  89. ncbi Rapid measurement of B-type natriuretic peptide in the emergency diagnosis of heart failure
    Alan S Maisel
    University of California, San Diego, Veterans Affairs Medical Center, San Diego 92161, USA
    N Engl J Med 347:161-7. 2002
    ..B-type natriuretic peptide is released from the cardiac ventricles in response to increased wall tension...
  90. ncbi Relationship between daily living activities (ADL) limitation and the BODE index in patients with chronic obstructive pulmonary disease
    Karen M Simon
    Departamento de Fisioterapia, Universidade Federal do Pampa UNIPAMPA, Uruguaiana, RS, Brasil
    Rev Bras Fisioter 15:212-8. 2011
    ..A close relationship between morbidity and mortality with functional limitation is observed in patients with COPD...
  91. pmc Dyspnea-12 is a valid and reliable measure of breathlessness in patients with interstitial lung disease
    Janelle Yorke
    Faculty of Health and Social Care, School of Nursing, University of Salford, Greater Manchester, England
    Chest 139:159-64. 2011
    In this study, we aimed to determine the validity and reliability of the Dyspnea-12 questionnaire (D-12) for the assessment of breathlessness in patients with interstitial lung disease (ILD).
  92. ncbi Ventilatory constraints and dyspnea during exercise in chronic obstructive pulmonary disease
    Pierantonio Laveneziana
    Division of Respiratory and Critical Care Medicine, Department of Medicine, Queen s University, 102 Stuart St, Kingston, ON K7L 2V6
    Appl Physiol Nutr Metab 32:1225-38. 2007
    b>Dyspnea (respiratory difficulty) and activity limitation are the primary symptoms of chronic obstructive pulmonary disease (COPD) and progress relentlessly as the disease advances, contributing to reduced quality of life...
  93. pmc Health-related quality of life in outpatients with COPD in daily practice: the VICE Spanish Study
    Antonio Martin
    Medical Department, Pfizer, Madrid, Spain
    Int J Chron Obstruct Pulmon Dis 3:683-92. 2008
    ..The objective of this study was to measure health-related quality of life (HRQL) in outpatients with chronic obstructive pulmonary disease (COPD) and to assess differences in HRQL according to age, gender, and severity of COPD...
  94. doi Severe exacerbations and BODE index: two independent risk factors for death in male COPD patients
    Juan José Soler-Cataluña
    Hospital General de Requena, Unidad de Neumología, Servicio de Medicina Interna, Paraje Casablanca s n, 46340 Requena, Valencia, Spain
    Respir Med 103:692-9. 2009
    ....
  95. ncbi Mechanisms of dyspnea during cycle exercise in symptomatic patients with GOLD stage I chronic obstructive pulmonary disease
    Dror Ofir
    F R C P C, 102 Stuart Street, Kingston, ON, K7L 2V6 Canada
    Am J Respir Crit Care Med 177:622-9. 2008
    Smokers with a relatively preserved FEV(1) may experience dyspnea and activity limitation but little is known about underlying mechanisms.
  96. ncbi Does the BODE index reflect the level of physical activity in daily life in patients with COPD?
    Leandro C Mantoani
    Laboratory of Research in Pulmonary Physical Therapy, Physical Therapy Department, Universidade Estadual de Londrina, Londrina, PR, Brazil
    Rev Bras Fisioter 15:131-7. 2011
    ..To study the relationship between the level of physical activity in daily life and disease severity assessed by the BODE index in patients with chronic obstructive pulmonary disease (COPD)...
  97. pmc Analysis of longitudinal changes in dyspnea of patients with chronic obstructive pulmonary disease: an observational study
    Toru Oga
    Department of Respiratory Care and Sleep Control Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    Respir Res 13:85. 2012
    ..However, limited data are available regarding the longitudinal change in dyspnea, and it remains unknown which of relevant measurements might be used for following dyspnea.
  98. doi Hemodynamic determinants of dyspnea improvement in acute decompensated heart failure
    Amir Solomonica
    Department of Cardiology, Rambam Medical Center, Haifa, Israel
    Circ Heart Fail 6:53-60. 2013
    b>Dyspnea relief constitutes a major treatment goal and a key measure of treatment efficacy in decompensated heart failure...
  99. ncbi An evaluation of the acute impact of pursed lips breathing on walking distance in nonspontaneous pursed lips breathing chronic obstructive pulmonary disease patients
    R Garrod
    School of Physiotherapy, Kingston University and St George s Hospital Medical School, London
    Chron Respir Dis 2:67-72. 2005
    ..Reductions in RR appear to be greatest in those patients with resting breathlessness...
  100. pmc Improving the quality of life in patients with chronic obstructive pulmonary disease: focus on indacaterol
    Gregory J Feldman
    S Carolina Pharmaceutical Research, Alliance Biomedical Group International, Spartanburg, SC 29303, USA
    Int J Chron Obstruct Pulmon Dis 8:89-96. 2013
    ..becomes inefficient, with the end result being an avoidance of physical exertion and a cycle of increasing dyspnea caused by inactivity and deconditioning, with deleterious effects on HR-QOL...
  101. pmc Proposing a standardized method for evaluating patient report of the intensity of dyspnea during exercise testing in COPD
    Asha Hareendran
    United BioSource Corporation, London, UK
    Int J Chron Obstruct Pulmon Dis 7:345-55. 2012
    Measuring dyspnea intensity associated with exercise provides insights into dyspnea-limited exercise capacity, and has been used to evaluate treatment outcomes for chronic obstructive pulmonary disease (COPD)...

Research Grants84

  1. Neurotrophins in the Lung
    Y S Prakash; Fiscal Year: 2012
    ..By establishing the role of neurotrophins in airway narrowing with or without inflammation, the proposed studies will the foundation for better understanding of airway diseases, and potential development of new therapeutic targets. ..
  2. Immune modulators of inflammation in servere COPD
    Farrah Kheradmand; Fiscal Year: 2010
    ..In this application, we will study the role of a subset of cells in the immune system called T helper cells to determine if they could be responsible for the destruction of lung in subjects with COPD and emphysema. ..
  3. Tadalafil for Pulmonary Hypertension Associated with Chronic Lung Disease
    SHARON IRENE SMITH ROUNDS; Fiscal Year: 2013
    ..by 2-dimensional echocardiography of pulmonary artery systolic pressure and right ventricular function, dyspnea severity, health related quality of life assessed by validated standardized questionnaires, and, the frequency of ..
  4. A Pilot Study of Yoga for Breathing and Quality of Life of Lung Cancer Patients
    JUDITH MARIE FOULADBAKHSH; Fiscal Year: 2013
    ..standardized, 12-week yoga intervention on breathing, specifically spirometry values, respiratory rate, reported dyspnea intensity and discomfort, oxygenation, and breathing awareness of Stage I-IIIa NSCLC patients as compared with a ..
  5. Coping Skills Training in Heart Failure: Outcomes and Mechanisms
    Andrew Sherwood; Fiscal Year: 2013
    ..HF symptoms, including dyspnea and fatigue, are a major source of distress for patients with HF, and often impose severe limitations on their ..
  6. Analysis of associations between anemia correction in CKD and mortality: CHOIR
    LYNDA ANNE MARIE SZCZECH; Fiscal Year: 2010
    ....
  7. Reduced contractile reserve: a therapeutic target in heart failure with normal EF
    Nancy K Sweitzer; Fiscal Year: 2012
    ..This project explores the underlying cardiovascular physiology of patients with HFpEF with the goal of identifying new therapeutic targets that would allow improved treatment of this devastating disease. ..
  8. Age-associated Toll-like receptor dysfunction in the lungs
    Carlos J Orihuela; Fiscal Year: 2010
    ..why 10% of the elderly with pneumonia show no overt clinical signs of infection such as fever, cough, or dyspnea;and 3) why lack of fever is a prognostic indicator of poor clinical outcome...
  9. Mechanisms of Respiratory Muscle Dysfunction in Heart Failure
    LEONARDO FERREIRA; Fiscal Year: 2013
    ..Aim 2. To define SMase as a mediator of diaphragm muscle dysfunction in CHF. Aim 3: To test the role of NAD(P)H oxidase on diaphragm muscle dysfunction of CHF mice. ..
  10. Countermeasures for chlorine-induced airway fibrosis
    Gary W Hoyle; Fiscal Year: 2013
    ..Acute effects of chlorine inhalation include dyspnea, hypoxemia, pneumonitis, and pulmonary edema...
  11. Tai Chi after Pulmonary Rehabilitation in Patients with COPD: A Randomized Trial
    Gloria Y Yeh; Fiscal Year: 2013
    ..Pulmonary rehabilitation (PR) has been shown to improve symptoms of dyspnea, health-related quality of life, and exercise capacity and national guidelines now recommend that all patients ..
  12. The Efficacy of Pranayama in COPD
    David A Kaminsky; Fiscal Year: 2013
    ..Patients with COPD mainly complain of shortness of breath with daily activities and exercise. A key mechanism of dyspnea is dynamic hyperinflation, or air trapping, which results from the severe airflow limitation that characterizes ..
  13. Translating CBT-Insomnia for Lung Cancer into practice: A RCT
    Grace E Dean; Fiscal Year: 2013
    ..radiotherapy can result in impaired pulmonary function resulting in hyperarousal from pain, cough and dyspnea leading to a worsening of insomnia...
  14. Calcium Regulation in Airway Smooth Muscle
    Gary C Sieck; Fiscal Year: 2013
    ..These studies will the foundation for better understanding of airway diseases, and potential development of new therapeutic targets. ..
  15. The Role of Caveolins in Lung Inflammation
    CHRISTINA MARIA PABELICK; Fiscal Year: 2013
    ....
  16. Telephone-based coping skills training for COPD
    James A Blumenthal; Fiscal Year: 2012
    ..COPD is an obstructive airway disease marked by symptoms of dyspnea, paroxysmal coughing, pain, fatigue, and insomnia. Approximately 12...
  17. Microbiome in Chronic Obstructive Pulmonary Disease
    Rubin M Tuder; Fiscal Year: 2010
    ..We propose to use the lung tissues collected by the LTRC and translate a novel and state of the art method to perform a large scale screen of the bacteria that may present in normal and diseased lungs. (End of Abstract) ..
  18. Effectiveness of an Automated Walking Program Targeting Veterans with COPD
    Caroline R Richardson; Fiscal Year: 2013
    ..pulmonary rehabilitation program experience significant improvements in health related quality of life, dyspnea, and exercise tolerance as well as reduced rates of hospitalization...
  19. Self-Management, Biobehavioral and Informatics Core
    Nancy E Reame; Fiscal Year: 2011
    ..of nursing science is its application of biobehavioral approaches to key phenomena of interest to nursing such as dyspnea, heart failure, pain, menopause, adherence, and glycemic control...
  20. Dyspnea on Exertion in Obesity: Effects of Exercise Training and Weight Loss
    Tony G Babb; Fiscal Year: 2013
    ..Many obese adults experience exertional dyspnea and are unable to exercise...
  21. Muscle Afferent Feedback Effects in Patients with Heart Failure
    Markus Amann; Fiscal Year: 2013
    ..of these characteristics include excessive exercise pressor reflex, premature fatigue, and exertional dyspnea. Abnormally elevated neural feedback from mechano- and/or metabosensitive group III and IV muscle afferents might ..
  22. Standardized Rehabilitation for ICU Patients with Acute Respiratory Failure
    Peter E Morris; Fiscal Year: 2013
    ..Patients with ARF experience deconditioning, muscle weakness, joint contractures, dyspnea, depression, and reduced health-related quality of life, all of which may contribute to prolonged hospitalization ..
  23. Outcomes Research in Rheumatic Diseases
    Dinesh Khanna; Fiscal Year: 2013
    ..To determine the relationship between the vitamin D status and physiological, radiological, and dyspnea measures of scleroderma-associated interstitial lung disease (SSc-ILD) in an ongoing NIH funded clinical trial ..
  24. MOCSLID-DCC
    Robert M Elashoff; Fiscal Year: 2012
    ..responds to a one- year treatment with oral cyclophosphamide (CYC) with improvements in pulmonary function, dyspnea, skin disease, and health-related quality of life (HRQoL)...
  25. Early Acute Lung Injury: Prospective Evaluation Prior to Respiratory Failure
    Joseph Levitt; Fiscal Year: 2013
    ..Clinical characteristics (demographics, diagnoses, comorbidities, vital signs, and Borg dyspnea scores) will be recorded for the first 72 hours of admission...
  26. Temporal analysis of nitric oxide as potential sepsis biomarker
    Mark H Schoenfisch; Fiscal Year: 2013
    ..The temporal changes of these analytes will then be evaluated in an appropriate animal (porcine) model of sepsis to determine their predictive value. ..
  27. Clinical and Autonomic Effects of Mind-Body Exercise in COPD
    Gloria Y Yeh; Fiscal Year: 2013
    ..Patients with COPD (Global Obstructive Lung Disease stages 1-3 with symptoms of dyspnea) will be recruited from outpatient primary care and pulmonary clinics...
  28. Depression and functional outcomes in COPD: Impact of genetics and inflammation
    Huong Q Nguyen; Fiscal Year: 2013
    ..on decline in functional outcomes (six minute walk test distance, physical activity measured with accelerometers, dyspnea severity, and health related quality of life) in COPD over 2 years...
  29. Resolution of ozone induced lung injury requires gamma/delta T cells
    Joel A Mathews; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Exposure to ozone (O3), a common air pollutant, causes cough, dyspnea, reductions in lung function, increased susceptibility to lung infections, hospitalizations, increased asthma attacks, and even ..
  30. AEROSOL FUROSEMIDE FOR DYSPNEA RELIEF: LABORATORY AND CLINICAL STUDIES
    Robert B Banzett; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Dyspnea is a major problem in many classes of patients including ICU patients, patients with chronic lung and heart disease, and patients nearing the end of life from most causes...
  31. Arsenic and child respiratory health in Bangladesh
    Allan H Smith; Fiscal Year: 2010
    ....
  32. Development of anti-human TL1A monoclonal antibody for the treatment of human ast
    Vadim V Deyev; Fiscal Year: 2010
    ....
  33. Electro-mechanical Resynchronization Therapy For Arrhythmogenic Right Ventricular
    Harikrishna Tandri; Fiscal Year: 2012
    ..Finally, insights gained from gap junctional protein expression in ARVC may stimulate research in the role of gap junctional proteins in arrhythmogenesis in other inherited cardiomyopathies. (End of Abstract) ..
  34. Inhibition of the SDF-1/CXCR4 axis as preventive therapy for radiation-induced pu
    HUI KUO contact SHU; Fiscal Year: 2010
    ..If successful, this drug may be carried forward to clinical trial to attempt to prevent this potentially debilitating side effect of radiation treatments. ..
  35. Efficacy and mechanisms of a behavioral therapy for insomnia coexisting with COPD
    Mary C Kapella; Fiscal Year: 2013
    ..Common features of COPD such as dyspnea, chronic inflammation, anxiety and depression also affect insomnia and can interfere with therapy outcomes...
  36. Lethal H5N1 Virus Infection and Respiratory Disorders
    Fadi Xu; Fiscal Year: 2013
    ..A (H5N1) virus infection results in ~60% mortality in patients who present respiratory abnormalities from dyspnea and pulmonary inflammation during the first 6 days post-infection to respiratory failure with hypoxemia, leading ..
  37. Building Capacity for Rural Integrated Palliative Care: Bridges to Healthy Transi
    KATHARINE JOY BUCK; Fiscal Year: 2010
    ..to navigate myriad transitions in care while experiencing debilitating symptoms such as profound fatigue, dyspnea, breathlessness and pain for years prior to death...
  38. MOCSLID-CCC
    Donald P Tashkin; Fiscal Year: 2012
    ..responds to a one year treatment with oral cyclophosphamide (CYC) with improvements in pulmonary function, dyspnea, skin disease, and health-related quality of life (HRQoL)...
  39. Stimulation Induced Modulation of Sleep
    MATTHEW TARLER; Fiscal Year: 2009
    ..Transcervical DC stimulation may also be able to modulate the sensation of dyspnea in chronic obstructive lung disease...
  40. Heart Camp: Promoting Adherence to Exercise in Patients with Heart Failure
    Bunny Pozehl; Fiscal Year: 2013
    ..Improving long-term adherence to exercise is the logical first step to ensure the required dose of exercise that is necessary to realize beneficial health outcomes and reduce costs in this burdensome chronic illness. ..
  41. Palliative Care Symptom Management in Rural Communities
    Ardith Z Doorenbos; Fiscal Year: 2013
    ..by applicant): Palliative care aims to provide relief of pain and other patient symptoms, such as fatigue, dyspnea, constipation, anxiety, and depression, in order to improve quality of life...
  42. EVALUATION OF ENDOBRONCHIAL INTERVENTIONS FOR COPD VIA CT AND 3HE MRI
    Jason C Woods; Fiscal Year: 2011
    ..Both proposed interventions show great promise at reducing dyspnea in patients with severe emphysema, for which there is no therapeutic treatment option other than lung ..
  43. PHARMACOGENOMICS OF INHALED CORTICOSTEROIDS TO REDUCE COPD EXACERBATIONS
    Craig P Hersh; Fiscal Year: 2013
    ..Acute exacerbations of chronic obstructive pulmonary disease (COPD), characterized by symptoms of worsening dyspnea, increased cough and sputum production, are troubling episodes for patients, leading them to seek medical care...
  44. Understanding the Lung Microbiome in HIV-Infected and HIV-uninfected individuals
    Vincent B Young; Fiscal Year: 2013
    ..Furthermore, we anticipate that microbiota data will relate directly to subject reports of sputum production and dyspnea. In specific aim 3, we will compare colonization with Pneumocystis in HIV-infected and HIV- uninfected ..
  45. A percutaneous cardiac implant to treat mitral valve regurgitation
    Michael Lesh; Fiscal Year: 2013
    ..Our long- term goal is approval by the FDA for commercial sale within the US via the Premarket Approval process. ..
  46. Quantifying a Vital Symptom: Large-scale Inpatient Dyspnea Measurement
    Robert B Banzett; Fiscal Year: 2013
    PROJECT SUMMARY Shortness of breath (Dyspnea) is both a predictor of life-threatening illness and a common symptom that causes suffering if not adequately managed...
  47. Rectal Medication Administration Device for Palliative Care
    BRADFORD MACY; Fiscal Year: 2013
    ..During this time, symptom management can become more difficult, as symptoms such as pain, dyspnea, nausea, and agitation tend to worsen...
  48. B-Blocker effect on a range of health outcomes in older adults with CAD and COPD
    Mary E Tinetti; Fiscal Year: 2010
    ..is associated with fewer CV events and lower mortality but more frequent adverse pulmonary outcomes;worse dyspnea, fatigue, and activity levels and greater disability than no or lower 2-Blocker intensity...
  49. Airway sensors with myelinated afferents
    JERRY J YU; Fiscal Year: 2013
    ..b>Dyspnea, bronchial inflammation, hyperreactivity, coughing, and mucus secretion occur when airway sensory receptors are ..
  50. Mitochondrial reactive oxygen species induce airway sensory nerve activity
    THOMAS EDWARD TAYLOR-CLARK; Fiscal Year: 2013
    ..inflammation in the airways perverts vagal sensory C-fiber function, resulting in excessive and chronic cough, dyspnea, mucus secretion and bronchospasm in airway diseases including asthma, viral exacerbations and COPD...
  51. Pulmonary Rehabilitation for Idiopathic Pulmonary Fibrosis
    Jeffrey J Swigris; Fiscal Year: 2013
    ..The goals of the specific project outlined in this proposal are to characterize the life-altering sequelae of IPF^dyspnea and impairments in functional capacity, cognitive function, mood and anxiety, fatigue, and quality of life (QOL)- ..
  52. Adjustable balloon implant for medialization thyroplasty
    Matthew R Hoffman; Fiscal Year: 2012
    ..Postoperative complications such as penetration and breathy phonation due to hypoadduction or dyspnea and pressed phonation due to hyperadduction are not uncommon;therefore, being able to adjust the degree of ..
  53. Radiation-Induced Cardiopulmonary Injury in Humans
    Lawrence B Marks; Fiscal Year: 2012
    ..This information will lead to algorithms that accurately predict the risk of cardiopulmonary injury, facilitate the design of "safer" 3D dose distributions, and thus improve patient care. ..
  54. Palliative Care Provider Online Education in Evidence-Based Complementary Therapi
    Leila Kozak; Fiscal Year: 2011
    ..Conduct evidence-based reviews of the literature on the application of complementary therapies to pain and dyspnea in palliative care settings. Aim 3...
  55. Chemokine Modulation of Airway Vagal Sensory Nerves
    CARL ROBERT POTENZIERI; Fiscal Year: 2011
    ..Activation of bronchopulmonary C-fibers results in the initiation of defensive reflexes such as urge to cough, dyspnea, and increased cholinergic output leading to mucus secretion and bronchoconstriction to aid in the clearance of ..
  56. A Study of Narrative as the Cognitivie Process Underlying Diagnostic Reasoning
    CURTIS SCOTT SMITH; Fiscal Year: 2010
    ..unreadable] ..
  57. Computer Assisted Symptom Management for Patients Receiving Radiation Therapy
    Erik K Fromme; Fiscal Year: 2010
    ..Most people living with cancer eventually experience significant symptoms such as pain, nausea, dyspnea, fatigue, insomnia, anxiety, depression, constipation, and anorexia...
  58. Diabetic Microangiopathy and Alveolar O2 Transport
    Connie C W Hsia; Fiscal Year: 2010
    ..large alveolar-capillary reserves, extensive loss of the microvascular bed can be tolerated without developing dyspnea at rest;hence pulmonary diabetic microangiopathy is under-recognized clinically...
  59. Alzheimers Medical Advisor: A Symptom and Sign Management Toolkit for Caregivers
    Philip D Sloane; Fiscal Year: 2013
    ....
  60. Adapting Natural Language Processing Tools for Biosurveillance
    Debbie A Travers; Fiscal Year: 2011
    ..This proposed project will further strengthen biosurveillance by adapting EMT-P and other statistical and classical natural language processing tools to develop a system that extracts concepts from triage notes for biosurveillance. ..
  61. Trial of Physical Activity Self-management Intervention for Patients with COPD
    David B Coultas; Fiscal Year: 2013
    ..e., Chronic Respiratory Questionnaire [CRQ] dyspnea domain and 6-minute walk) compared to patients who receive UC...
  62. Reducing Dynamic Hyperinflation through Breathing Retraining
    Eileen G Collins; Fiscal Year: 2013
    ..Lastly, we hypothesize that dyspnea will be reduced in patients assigned to breathing retraining plus exercise when compared to exercise training ..
  63. eCancer: A technological approach to symptom management from home to practice
    BRIAN DAVID DECKER; Fiscal Year: 2010
    ....
  64. REFLEXES IN LEFT VENTRICULAR DYSFUNCTION
    CHULANI KAPPAGODA; Fiscal Year: 2003
    ..Adapted from the applicant's abstract):Left ventricular dysfunction (LVD) is a syndrome which presents as dyspnea on exertion, wheezing, a rapid respiratory rate, and increased secretion of mucus...
  65. Mechanisms of Respiratory Muscle Dysfunction in Heart Failure
    LEONARDO FERREIRA; Fiscal Year: 2010
    ..Improvement of the respiratory muscle function should increase the patient's ability to perform daily tasks, and enhance quality of life. ..
  66. MVPS: Health Concerns, Role function, Health Service Use
    KRISTINE SCORDO; Fiscal Year: 2002
    ....
  67. Testing a Measurement Model of Acute Dyspnea
    Mark Parshall; Fiscal Year: 2005
    No existing dyspnea measure is focused on what patients perceive in terms of intensity, sensory quality, and distress of dyspnea, and none is theoretically or psychometrically suitable for serial assessment of dyspnea in acute care ..
  68. Photodynamic Therapy for the Treatment of Obstructive E*
    Todd Demmy; Fiscal Year: 2007
    ..Tumor response and symptom relief (cough, dyspnea, hemoptysis) will be determined at Day 5, one month and three months...
  69. Asthma Treatment with a Novel Drug Aerosol Generator
    William Shen; Fiscal Year: 2004
    ..Successful completion of activities in Phase I would present a significant step towards developing an improved inhalation drug delivery platform for asthma treatment. ..
  70. Sleep disorders and QOL in lung cancer survivors
    Nalaka Gooneratne; Fiscal Year: 2009
    ..is associated with significant impairments in quality of life even when controlling for other symptoms such as dyspnea, and that mortality rates may be higher in those with insomnia...
  71. Drug-eluting Tracheobronchial Stents to treat Obstruction caused by Lung Cancer
    Narmada Shenoy; Fiscal Year: 2007
    ..Palliative reopening of the affected airways often alleviates symptoms such as dyspnea, cough, or hemoptysis...
  72. Psychobiology of IV Naloxone & Lactate in Normals
    Donald Klein; Fiscal Year: 2005
    ..The panic attack is distinctively characterized by acute dyspnea, tidal volume hyperventilation and surprising lack of HPA activation...
  73. CLONING OF FAMILIAL PRIMARY PULMONARY HYPERTENSION GENE
    William Nichols; Fiscal Year: 2006
    ..Diagnosis can often be delayed because the initial symptoms of fatigue and dyspnea on exertion are nonspecific. Definitive diagnosis requires cardiac catheterization...
  74. DYSPNEA, AIRWAY RESISTANCE AND PRESSURE WITH SUCTIONING
    Carol Thompson; Fiscal Year: 1993
    The most frequent initial nursing intervention to treat dyspnea in mechanically ventilated patients is tracheal suction, yet research to direct these care decisions has just begun...
  75. Airway sensory nerves and dyspnea in human subjects
    Nausherwan Burki; Fiscal Year: 2004
    b>Dyspnea, an unpleasant sensation of difficulty in breathing, is a common symptom in patients with cardiopulmonary diseases, but the underlying mechanisms are unclear...
  76. Dignity Intervention for Terminally Ill Cancer Patients
    Harvey Chochinov; Fiscal Year: 2007
    ..Patient distress associated with symptoms such as pain, nausea, dyspnea, and even to a degree depression and anxiety, have been the focus of some targeted research...
  77. NURSING MODEL--RESPIRATORY MUSCLE STRENGTH IN COPD
    Janet Larson; Fiscal Year: 2001
    ..risk for the development of respiratory muscle fatigue and ventilatory failure and contributes to sensations of dyspnea and ultimately to a decrease in functional performance...
  78. Pulsus Paradoxus Monitor
    Gregory Jay; Fiscal Year: 2005
    ..is a valuable pathological vital sign in the management of asthma and in the rapid evaluation of patients with dyspnea in general...
  79. VENTING FOR REDUCTION OF HYPERINFLATION IN EMPHYSEMA
    Joel Cooper; Fiscal Year: 2005
    ..The crippling effects of end-stage emphysema, including severe dyspnea, relate not only to loss of lung substance but also to the dynamic hyperinflation of the lungs associated with ..
  80. RESPIRATORY CONSEQUENCES OF OPIATES
    TEODORO SANTIAGO; Fiscal Year: 1992
    ..We have suggested that opioid elaboration in this setting relieves dyspnea and possibly postpones fatigue of the respiratory muscles...
  81. ORAL CYCLOPHOSPHAMIDE VS ORAL PLACEBO IN SSC ALVEOLITIS
    Dean Schraufnagel; Fiscal Year: 2003
    ..at least moderate functional impairment and perceived magnitude of task and effort on the Mahler Baseline Dyspnea Index), have an FVC equal to or <85% of predicted and exhibit active alveolitis defined as equal to or >3...
  82. ORAL CYCLOPHOSPHAMIDE VS ORAL PLACEBO IN SSC ALVEOLITIS
    Daniel Furst; Fiscal Year: 2001
    ..at least moderate functional impairment and perceived magnitude of task and effort on the Mahler Baseline Dyspnea Index), have an FVC less than 85 percent of predicted and exhibit active alveolitis defined as greater than or ..
  83. ORAL CYCLOPHOSPHAMIDE VS ORAL PLACEBO IN SSC ALVEOLITIS
    James Dauber; Fiscal Year: 2000
    ..at least moderate functional impairment and perceived magnitude of task and effort on the Mahler Baseline Dyspnea Index), have an FVC equal to or <85% of predicted and exhibit active alveolitis defined as equal to or >3...