obstructive sleep apnea

Summary

Summary: A disorder characterized by recurrent apneas during sleep despite persistent respiratory efforts. It is due to upper airway obstruction. The respiratory pauses may induce HYPERCAPNIA or HYPOXIA. Cardiac ARRHYTHMIA and elevation of systemic and pulmonary arterial pressures may occur. Frequent partial arousals occur throughout sleep, resulting in relative SLEEP DEPRIVATION and daytime tiredness. Associated conditions include OBESITY; ACROMEGALY; MYXEDEMA; micrognathia; MYOTONIC DYSTROPHY; adenotonsilar dystrophy; and NEUROMUSCULAR DISEASES. (From Adams et al., Principles of Neurology, 6th ed, p395)

Top Publications

  1. pmc Effects of nocturnal continuous positive airway pressure therapy in patients with resistant hypertension and obstructive sleep apnea
    Tarek A Dernaika
    University of Oklahoma Health Sciences Center, Pulmonary and Critical Care Medicine, 920 Stanton L Young Blvd, WP 1310, Oklahoma City, OK 73104, USA
    J Clin Sleep Med 5:103-7. 2009
  2. pmc Clinical guideline for the evaluation, management and long-term care of obstructive sleep apnea in adults
    Lawrence J Epstein
    Sleep HealthCenters, Brighton, MA 02135, USA
    J Clin Sleep Med 5:263-76. 2009
  3. ncbi Epidemiology of obstructive sleep apnea: a population health perspective
    Terry Young
    Department of Population Health Sciences, University of Wisconsin Madison, Madison, Wisconsin 53705, USA
    Am J Respir Crit Care Med 165:1217-39. 2002
  4. ncbi Long-term cardiovascular outcomes in men with obstructive sleep apnoea-hypopnoea with or without treatment with continuous positive airway pressure: an observational study
    Jose M Marin
    Respiratory Service, Hospital Universitario Miguel Servet, Isabel la Catolica, Zaragoza, Spain
    Lancet 365:1046-53. 2005
  5. pmc Prospective study of obstructive sleep apnea and incident coronary heart disease and heart failure: the sleep heart health study
    Daniel J Gottlieb
    VA Boston Healthcare System, and Boston University School of Medicine, 715 Albany Street, Boston, MA 02118 2394, USA
    Circulation 122:352-60. 2010
  6. pmc The epidemiology of adult obstructive sleep apnea
    Naresh M Punjabi
    Division of Pulmonary and Critical Care Medicine, Johns Hopkins University, Baltimore, MD 21224, USA
    Proc Am Thorac Soc 5:136-43. 2008
  7. ncbi Obstructive sleep apnea as a risk factor for stroke and death
    H Klar Yaggi
    Section of Pulmonary and Critical Care Medicine, Yale Center for Sleep Medicine, Yale University School of Medicine, New Haven, Conn 06520, USA
    N Engl J Med 353:2034-41. 2005
  8. pmc Obstructive sleep apnea as a risk factor for type 2 diabetes
    Nader Botros
    Division of Pulmonary, Critical Care, and Sleep Medicine, Yale University School of Medicine, New Haven, Conn
    Am J Med 122:1122-7. 2009
  9. ncbi Obstructive sleep apnea syndrome in the Sao Paulo Epidemiologic Sleep Study
    Sergio Tufik
    Disciplina de Medicina e Biologia do Sono, Departamento de Psicobiologia, Universidade Federal de Sao Paulo UNIFESP, Sao Paulo, Brazil
    Sleep Med 11:441-6. 2010
  10. ncbi Obstructive sleep apnea: implications for cardiac and vascular disease
    Abu S M Shamsuzzaman
    Mayo Clinic and Mayo Foundation, Rochester, Minn 55905, USA
    JAMA 290:1906-14. 2003

Detail Information

Publications345 found, 100 shown here

  1. pmc Effects of nocturnal continuous positive airway pressure therapy in patients with resistant hypertension and obstructive sleep apnea
    Tarek A Dernaika
    University of Oklahoma Health Sciences Center, Pulmonary and Critical Care Medicine, 920 Stanton L Young Blvd, WP 1310, Oklahoma City, OK 73104, USA
    J Clin Sleep Med 5:103-7. 2009
    To examine the long-term effects of continuous positive airway pressure (CPAP) therapy on blood pressure (BP) in patients with obstructive sleep apnea and resistant hypertension.
  2. pmc Clinical guideline for the evaluation, management and long-term care of obstructive sleep apnea in adults
    Lawrence J Epstein
    Sleep HealthCenters, Brighton, MA 02135, USA
    J Clin Sleep Med 5:263-76. 2009
    b>Obstructive sleep apnea (OSA) is a common chronic disorder that often requires lifelong care. Available practice parameters provide evidence-based recommendations for addressing aspects of care.
  3. ncbi Epidemiology of obstructive sleep apnea: a population health perspective
    Terry Young
    Department of Population Health Sciences, University of Wisconsin Madison, Madison, Wisconsin 53705, USA
    Am J Respir Crit Care Med 165:1217-39. 2002
    ..epidemiologic studies have uncovered the high prevalence and wide severity spectrum of undiagnosed obstructive sleep apnea, and have consistently found that even mild obstructive sleep apnea is associated with significant ..
  4. ncbi Long-term cardiovascular outcomes in men with obstructive sleep apnoea-hypopnoea with or without treatment with continuous positive airway pressure: an observational study
    Jose M Marin
    Respiratory Service, Hospital Universitario Miguel Servet, Isabel la Catolica, Zaragoza, Spain
    Lancet 365:1046-53. 2005
    ....
  5. pmc Prospective study of obstructive sleep apnea and incident coronary heart disease and heart failure: the sleep heart health study
    Daniel J Gottlieb
    VA Boston Healthcare System, and Boston University School of Medicine, 715 Albany Street, Boston, MA 02118 2394, USA
    Circulation 122:352-60. 2010
    Clinic-based observational studies in men have reported that obstructive sleep apnea is associated with an increased incidence of coronary heart disease...
  6. pmc The epidemiology of adult obstructive sleep apnea
    Naresh M Punjabi
    Division of Pulmonary and Critical Care Medicine, Johns Hopkins University, Baltimore, MD 21224, USA
    Proc Am Thorac Soc 5:136-43. 2008
    b>Obstructive sleep apnea is a chronic condition characterized by frequent episodes of upper airway collapse during sleep. Its effect on nocturnal sleep quality and ensuing daytime fatigue and sleepiness are widely acknowledged...
  7. ncbi Obstructive sleep apnea as a risk factor for stroke and death
    H Klar Yaggi
    Section of Pulmonary and Critical Care Medicine, Yale Center for Sleep Medicine, Yale University School of Medicine, New Haven, Conn 06520, USA
    N Engl J Med 353:2034-41. 2005
    Previous studies have suggested that the obstructive sleep apnea syndrome may be an important risk factor for stroke...
  8. pmc Obstructive sleep apnea as a risk factor for type 2 diabetes
    Nader Botros
    Division of Pulmonary, Critical Care, and Sleep Medicine, Yale University School of Medicine, New Haven, Conn
    Am J Med 122:1122-7. 2009
    Cross-sectional studies have documented the co-occurrence of obstructive sleep apnea (hereafter, sleep apnea) with glucose intolerance, insulin resistance, and type 2 diabetes mellitus (hereafter, diabetes)...
  9. ncbi Obstructive sleep apnea syndrome in the Sao Paulo Epidemiologic Sleep Study
    Sergio Tufik
    Disciplina de Medicina e Biologia do Sono, Departamento de Psicobiologia, Universidade Federal de Sao Paulo UNIFESP, Sao Paulo, Brazil
    Sleep Med 11:441-6. 2010
    To estimate the prevalence of Obstructive Sleep Apnea Syndrome (OSAS), using current clinical and epidemiological techniques, among the adult population of Sao Paulo, Brazil.
  10. ncbi Obstructive sleep apnea: implications for cardiac and vascular disease
    Abu S M Shamsuzzaman
    Mayo Clinic and Mayo Foundation, Rochester, Minn 55905, USA
    JAMA 290:1906-14. 2003
    b>Obstructive sleep apnea (OSA) has been increasingly implicated in the initiation and progression of cardiovascular diseases.
  11. ncbi Elevated levels of C-reactive protein and interleukin-6 in patients with obstructive sleep apnea syndrome are decreased by nasal continuous positive airway pressure
    Takuya Yokoe
    First Department of Internal Medicine, Showa University, Tokyo, Japan
    Circulation 107:1129-34. 2003
    ..In the present study, we examined serum levels of CRP and IL-6, IL-6 production by monocytes, and the effect of nasal continuous positive airway pressure (nCPAP) in patients with obstructive sleep apnea syndrome (OSAS).
  12. ncbi Functional magnetic resonance imaging responses to expiratory loading in obstructive sleep apnea
    P M Macey
    Department of Neurobiology, University of California at Los Angeles, Los Angeles, CA 90095 1763, USA
    Respir Physiol Neurobiol 138:275-90. 2003
    b>Obstructive sleep apnea (OSA) is characterized by diminished upper airway muscle phasic and tonic activation during sleep, but enhanced activity during waking...
  13. ncbi Association of atrial fibrillation and obstructive sleep apnea
    Apoor S Gami
    Division of Cardiovascular Diseases, Mayo Clinic College of Medicine, 200 First St SW, Rochester, Minn 55905, USA
    Circulation 110:364-7. 2004
    b>Obstructive sleep apnea (OSA) is associated with recurrent atrial fibrillation (AF) after electrocardioversion...
  14. pmc Obstructive sleep apnea-hypopnea and incident stroke: the sleep heart health study
    Susan Redline
    Brigham and Women s Hospital, 221 Longwood Ave, Boston, MA 02115M, USA
    Am J Respir Crit Care Med 182:269-77. 2010
    Although obstructive sleep apnea is associated with physiological perturbations that increase risk of hypertension and are proatherogenic, it is uncertain whether sleep apnea is associated with increased stroke risk in the general ..
  15. pmc Brain structural changes in obstructive sleep apnea
    Paul M Macey
    Brain Research Institute, David Geffen School of Medicine at UCLA, University of California Los Angeles, Los Angeles, CA, USA
    Sleep 31:967-77. 2008
    Determine whether obstructive sleep apnea (OSA) subjects show indications of axonal injury.
  16. ncbi Brain morphology associated with obstructive sleep apnea
    Paul M Macey
    Department of Neurobiology and the Brain Research Institute, University of California at Los Angeles, Los Angeles, California 90095, USA
    Am J Respir Crit Care Med 166:1382-7. 2002
    b>Obstructive sleep apnea (OSA) is characterized by repeated occurrences of hypoxic, hypercapnic, and transient blood pressure elevation episodes that may damage or alter neural structures...
  17. ncbi Outcomes in patients with chronic obstructive pulmonary disease and obstructive sleep apnea: the overlap syndrome
    Jose M Marin
    Respiratory Service, Hospital Universitario Miguel Servet, Zaragoza 50009, Spain
    Am J Respir Crit Care Med 182:325-31. 2010
    Patients with chronic obstructive pulmonary disease (COPD) and obstructive sleep apnea (OSA) (overlap syndrome) are more likely to develop pulmonary hypertension than patients with either condition alone.
  18. ncbi Inspiratory loading elicits aberrant fMRI signal changes in obstructive sleep apnea
    Katherine E Macey
    Department of Neurobiology, University of California, Los Angeles, 90095 1763, USA
    Respir Physiol Neurobiol 151:44-60. 2006
    We hypothesized that neural processes mediating deficient sensory and autonomic regulatory mechanisms in obstructive sleep apnea (OSA) would be revealed by responses to inspiratory loading in brain regions regulating sensory and motor ..
  19. pmc Relationship between obstructive sleep apnea severity and brain activation during a sustained attention task
    Liat Ayalon
    Department of Psychiatry 151B, University of California, San Diego, 3350 La Jolla Village Dr, San Diego, CA 92161, USA
    Sleep 32:373-81. 2009
    ..were to (1) characterize cognitive and cerebral correlates of attention and response speed in patients with obstructive sleep apnea (OSA) and (2) assess the association of performance and brain activation with measures of OSA severity.
  20. ncbi Cerebral structural changes in severe obstructive sleep apnea
    Fergal J O'Donoghue
    Institute for Breathing and Sleep, Austin Health, Heidelberg 3081 West, Australia
    Am J Respir Crit Care Med 171:1185-90. 2005
    b>Obstructive sleep apnea is associated with abnormalities in neuropsychologic function, and defects in respiratory control may contribute to pathogenesis. Abnormalities may be reflected in structural brain changes...
  21. pmc Obstructive sleep apnea, cardiovascular disease, and pulmonary hypertension
    Jason M Golbin
    Division of Pulmonary, Mayo Clinic, Rochester, MN 55905, USA
    Proc Am Thorac Soc 5:200-6. 2008
    With the growing epidemic of obesity in an aging population, obstructive sleep apnea (OSA) is increasingly encountered in clinical practice...
  22. ncbi Obstructive sleep apnea is independently associated with insulin resistance
    Mary S M Ip
    Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong S A R, PR China
    Am J Respir Crit Care Med 165:670-6. 2002
    Epidemiological studies have implicated obstructive sleep apnea (OSA) as an independent comorbid factor in cardiovascular and cerebrovascular diseases...
  23. pmc Inflammation, oxidative stress, and repair capacity of the vascular endothelium in obstructive sleep apnea
    Sanja Jelic
    Columbia University College of Physicians and Surgeons, Division of Pulmonary, Allergy, and Critical Care Medicine, PH8 Center, Room 840, 630 W 168th St, New York, NY 10032, USA
    Circulation 117:2270-8. 2008
    ..evidence implicates endothelial dysfunction in the pathogenesis of vascular diseases associated with obstructive sleep apnea (OSA)...
  24. ncbi Sleep-disordered breathing and type 2 diabetes: a report from the International Diabetes Federation Taskforce on Epidemiology and Prevention
    Jonathan E Shaw
    International Diabetes Institute, 250 Kooyong Road, Caulfield, Melbourne, VIC 3162, Australia
    Diabetes Res Clin Pract 81:2-12. 2008
    ....
  25. ncbi Fixed and autoadjusting continuous positive airway pressure treatments are not similar in reducing cardiovascular risk factors in patients with obstructive sleep apnea
    Vincenzo Patruno
    Department of Respiratory Rehabilitation, S Marta Hospital, Rivoli d Adda, Ospedale Maggiore, Crema, Italy
    Chest 131:1393-9. 2007
    A strong association between obstructive sleep apnea (OSA) and the risk for cardiovascular and cerebrovascular diseases has been reported...
  26. ncbi Increased adhesion molecules expression and production of reactive oxygen species in leukocytes of sleep apnea patients
    Larissa Dyugovskaya
    Unit of Anatomy and Cell Biology and Sleep Laboratory, Technion Israel Institute of Technology, The Bruce Rappaport Faculty of Medicine, Haifa, Israel
    Am J Respir Crit Care Med 165:934-9. 2002
    b>Obstructive sleep apnea (OSA) is associated with increased cardiovascular morbidity and mortality. Free radicals and adhesion molecules were implicated in the pathogenesis of atherosclerosis leading to cardiovascular disorders...
  27. ncbi Mandibular advancement devices: rate of contraindications in 100 consecutive obstructive sleep apnea patients
    Francois Xavier Petit
    Department of Acute Specialized Medicine and Sleep Laboratory, PRETA Laboratory TIMC UMR CNRS 5525, University Hospital Grenoble, BP 217 X, 38043 Grenoble, France
    Am J Respir Crit Care Med 166:274-8. 2002
    ..The aim of the present study was to evaluate the proportion of the obstructive sleep apnea population that exhibits any contraindication (CI) to MAD...
  28. ncbi Sleep apnoea as an independent risk factor for cardiovascular disease: current evidence, basic mechanisms and research priorities
    W T McNicholas
    Respiratory Sleep Disorders Unit, St Vincent s University Hospital, Elm Park, Dublin 4, Ireland
    Eur Respir J 29:156-78. 2007
    ..Furthermore, translational studies involving cell culture and animal models linked to studies of obstructive sleep apnoea syndrome patients are necessary to integrate basic mechanisms with the clinical disorder...
  29. pmc Cardiovascular morbidity in obstructive sleep apnea: oxidative stress, inflammation, and much more
    David Gozal
    Kosair Children s Hospital Research Institute, University of Louisville School of Medicine, 570 South Preston Street, Suite 204, Louisville, KY 40202, USA
    Am J Respir Crit Care Med 177:369-75. 2008
    Sleep-disordered breathing and obstructive sleep apnea (OSA) are highly prevalent disorders throughout the lifespan, which may affect up to 2-10% of the population, and have now been firmly associated with an increased risk for ..
  30. ncbi Obstructive sleep apnea and metabolic syndrome: alterations in glucose metabolism and inflammation
    Esra Tasali
    Department of Medicine, University of Chicago, IL 60637, USA
    Proc Am Thorac Soc 5:207-17. 2008
    ..Recently, it has been suggested that obstructive sleep apnea (OSA), an increasingly prevalent condition, may contribute to the development of MS and diabetes...
  31. ncbi Endothelial function in obstructive sleep apnea and response to treatment
    Mary S M Ip
    Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong SAR, China
    Am J Respir Crit Care Med 169:348-53. 2004
    ..nitroglycerin (NTG)-induced dilation of the brachial artery with Doppler ultrasound in 28 men with obstructive sleep apnea (OSA) and 12 men without OSA. Subjects with OSA (apnea-hypopnea index; mean +/- SD, 46.0 +/- 14...
  32. ncbi Sleep-disordered breathing and insulin resistance in middle-aged and overweight men
    Naresh M Punjabi
    Division of Pulmonary and Critical Care Medicine, Asthma and Allergy Center, Johns Hopkins University School of Medicine, 5501 Hopkins Bayview Circle, Baltimore, MD 21224, USA
    Am J Respir Crit Care Med 165:677-82. 2002
    ..Thus, sleep-disordered breathing is a prevalent condition in mildly obese men and is independently associated with glucose intolerance and insulin resistance...
  33. ncbi Day-night pattern of sudden death in obstructive sleep apnea
    Apoor S Gami
    Division of Cardiovascular Diseases, Mayo Clinic College of Medicine, Rochester, Minn 55905, USA
    N Engl J Med 352:1206-14. 2005
    ..m. to noon and has a nadir from midnight to 6 a.m. Obstructive sleep apnea is highly prevalent and associated with neurohormonal and electrophysiological abnormalities that may ..
  34. ncbi Changes in brain morphology associated with obstructive sleep apnea
    Mary J Morrell
    National Heart and Lung Institute, Charing Cross Campus, Faculty of Medicine, Imperial College of Science Technology and Medicine, London, UK
    Sleep Med 4:451-4. 2003
    b>Obstructive sleep apnea (OSA) causes hypoxemia and fragmented sleep, which lead to neurocognitive deficits...
  35. pmc Molecular signatures of obstructive sleep apnea in adults: a review and perspective
    Erna S Arnardottir
    Center for Sleep and Respiratory Neurobiology, Division of Sleep Medicine Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Sleep 32:447-70. 2009
    The consequences of obstructive sleep apnea (OSA) are largely mediated by chronic intermittent hypoxia and sleep fragmentation. The primary molecular domains affected are sympathetic activity, oxidative stress and inflammation...
  36. ncbi Selective activation of inflammatory pathways by intermittent hypoxia in obstructive sleep apnea syndrome
    Silke Ryan
    Sleep Research Laboratory, St Vincent s University Hospital, Dublin, Ireland
    Circulation 112:2660-7. 2005
    b>Obstructive sleep apnea syndrome (OSAS), characterized by intermittent hypoxia/reoxygenation (IHR), is an independent risk factor for cardiovascular disease...
  37. pmc Clinical guidelines for the use of unattended portable monitors in the diagnosis of obstructive sleep apnea in adult patients. Portable Monitoring Task Force of the American Academy of Sleep Medicine
    Nancy A Collop
    Division of Pulmonary and Critical Care Medicine, Johns Hopkins University, Baltimore, MD 21205, USA
    J Clin Sleep Med 3:737-47. 2007
    ..AASM) makes the following recommendations: unattended portable monitoring (PM) for the diagnosis of obstructive sleep apnea (OSA) should be performed only in conjunction with a comprehensive sleep evaluation...
  38. ncbi Obstructive sleep apnea, obesity, and the risk of incident atrial fibrillation
    Apoor S Gami
    Division of Cardiovascular Diseases, Mayo Clinic College of Medicine, Rochester, Minnesota, USA
    J Am Coll Cardiol 49:565-71. 2007
    This study sought to identify whether obesity and obstructive sleep apnea (OSA) independently predict incident atrial fibrillation/flutter (AF).
  39. ncbi Prevalence of obstructive sleep apnea-hypopnea in severe versus moderate asthma
    Joanne Y Julien
    Meakins Christie Laboratories, McGill University, Montreal, Quebec, Canada
    J Allergy Clin Immunol 124:371-6. 2009
    Previous studies have suggested a link between obstructive sleep apnea and poor asthma control, which may be mediated through airway inflammation, obesity, and other mechanisms.
  40. ncbi Sympathetic chemoreflex responses in obstructive sleep apnea and effects of continuous positive airway pressure therapy
    Virginia A Imadojemu
    Division of Pulmonary, Allergy and Critical Care, Penn State Heart and Vascular Institute, 500 University Drive, Hershey, PA 17033, USA
    Chest 131:1406-13. 2007
    Sympathetic nerve activity is increased in awake and regularly breathing patients with obstructive sleep apnea (OSA). Over time, repetitive hypoxic stress could alter sympathetic chemoreflex function in OSA.
  41. ncbi Neuropsychological impairment and quality of life in obstructive sleep apnea
    Michael J Sateia
    Department of Psychiatry, Dartmouth Medical School, Sleep Disorders Center, Dartmouth Hitchcock Medical Center, 1 Medical Center Drive, Lebanon, NH 03756, USA
    Clin Chest Med 24:249-59. 2003
    ....
  42. ncbi Use of sample entropy approach to study heart rate variability in obstructive sleep apnea syndrome
    Haitham M Al-Angari
    Electrical and Computer Engineering Department, King Abdulaziz University, P O Box 80204, Jeddah, 21589, Saudi Arabia
    IEEE Trans Biomed Eng 54:1900-4. 2007
    ..used as a measure of signal complexity to evaluate the cyclic behavior of heart rate variability (HRV) in obstructive sleep apnea syndrome (OSAS)...
  43. ncbi Obesity hypoventilation syndrome: prevalence and predictors in patients with obstructive sleep apnea
    Babak Mokhlesi
    Sleep Disorders Center, Section of Pulmonary and Critical Care Medicine, The University of Chicago Pritzker School of Medicine, 5841 S Maryland Ave L11B, Chicago, IL 60637, USA
    Sleep Breath 11:117-24. 2007
    ..a greater risk of pulmonary hypertension, and a higher mortality compared to eucapnic patients with obstructive sleep apnea (OSA)...
  44. ncbi Obstructive sleep apnea in patients admitted for acute myocardial infarction. Prevalence, predictors, and effect on microvascular perfusion
    Chi Hang Lee
    Departments of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
    Chest 135:1488-95. 2009
    We investigated the prevalence and predictors of obstructive sleep apnea (OSA) in patients admitted to the hospital for acute myocardial infarction and whether OSA has any association with microvascular perfusion after primary ..
  45. ncbi Endothelial function in obstructive sleep apnea
    Amy Atkeson
    Division of Pulmonary, Allergy, and Critical Care Medicine, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Prog Cardiovasc Dis 51:351-62. 2009
    Untreated obstructive sleep apnea (OSA) is an independent risk factor for hypertension, myocardial infarction, and stroke. The repetitive hypoxia/reoxygenation and sleep fragmentation associated with OSA impair endothelial function...
  46. ncbi STOP questionnaire: a tool to screen patients for obstructive sleep apnea
    Frances Chung
    Department of Psychiatry, University of Toronto, Toronto Western Hospital, University Health Network, Toronto, Ontario, Canada
    Anesthesiology 108:812-21. 2008
    b>Obstructive sleep apnea (OSA) is a major risk factor for perioperative adverse events. However, no screening tool for OSA has been validated in surgical patients...
  47. ncbi Increased urinary leukotriene E4 excretion in obstructive sleep apnea: effects of obesity and hypoxia
    Françoise Stanke-Labesque
    Institut National de la Sante et de la Recherche Medicale, Grenoble, France
    J Allergy Clin Immunol 124:364-70, 370.e1-2. 2009
    Low-grade inflammation may potentially explain the relationship between obstructive sleep apnea syndrome (OSA) and cardiovascular events...
  48. ncbi Obstructive sleep apnea and pulmonary hypertension
    Dimitar Sajkov
    Flinders Medical Center, Bedford Park, SA, Australia
    Prog Cardiovasc Dis 51:363-70. 2009
    b>Obstructive sleep apnea (OSA) is associated with repetitive nocturnal arterial oxygen desaturation and hypercapnia, large intrathoracic negative pressure swings, and acute increases in pulmonary artery pressure...
  49. pmc Differences in craniofacial structures and obesity in Caucasian and Chinese patients with obstructive sleep apnea
    Richard W W Lee
    Centre for Sleep Health and Research, Department of Respiratory Medicine, Royal North Shore Hospital, NSW, Australia
    Sleep 33:1075-80. 2010
    To explore differences in craniofacial structures and obesity between Caucasian and Chinese patients with obstructive sleep apnea (OSA).
  50. pmc Association of obstructive sleep apnea risk with asthma control in adults
    Mihaela Teodorescu
    Medical Service, William S Middleton Memorial Veterans Hospital, Madison, WI, USA
    Chest 138:543-50. 2010
    Unrecognized obstructive sleep apnea (OSA) may lead to poor asthma control despite optimal therapy. Our objective was to evaluate the relationship between OSA risk and asthma control in adults.
  51. ncbi Obstructive sleep apnea as a risk factor for coronary events or cardiovascular death
    Neomi A Shah
    Yale Center for Sleep Medicine, New Haven, CT, USA
    Sleep Breath 14:131-6. 2010
    This study aims to determine whether obstructive sleep apnea independently increases the risk of coronary events, including death from cardiovascular causes.
  52. ncbi Computational fluid dynamics modeling of the upper airway of children with obstructive sleep apnea syndrome in steady flow
    Chun Xu
    Department of Mechanical Engineering and Mechanics, Drexel University, 3141 Chestnut St, STE 2 115, and Division of Pulmonary Medicine, Chidren s Hospital of Philadelphia, PA 19104, USA
    J Biomech 39:2043-54. 2006
    ..to model the effect of airway geometry on internal pressure in the upper airway of three children with obstructive sleep apnea syndrome (OSAS), and three controls...
  53. ncbi Sleep apnea and heart failure: Part I: obstructive sleep apnea
    T Douglas Bradley
    University of Toronto Centre for Sleep Medicine and Circadian Biology, Toronto, Ontario, Canada
    Circulation 107:1671-8. 2003
  54. pmc Obstructive sleep apnea syndrome is associated with deficits in verbal but not visual memory
    Gillian L Twigg
    Clinical and Academic Unit of Sleep and Ventilation, National Heart and Lung Institute, Royal Brompton Hospital, Imperial College, London, United Kingdom
    Am J Respir Crit Care Med 182:98-103. 2010
    ..Although cognitive deficits are well documented in patients with sleep apnea, the impact on memory remains unclear...
  55. ncbi A systematic review of screening questionnaires for obstructive sleep apnea
    Amir Abrishami
    Department of Anesthesia, Toronto Western Hospital, University Health Network, University of Toronto, 2 405 McL Wing, 399 Bathurst Street, Toronto, ON, M5T 2S8, Canada
    Can J Anaesth 57:423-38. 2010
    b>Obstructive sleep apnea (OSA) may lead to life-threatening problems if it is left undiagnosed. Polysomnography is the "gold standard" for OSA diagnosis; however, it is expensive and not widely available...
  56. ncbi Hippocampal area metabolites relate to severity and cognitive function in obstructive sleep apnea
    Delwyn J Bartlett
    Woolcock Institute of Medical Research, University of Sydney, Sydney, NSW, Australia
    Sleep Med 5:593-6. 2004
    b>Obstructive sleep apnea (OSA) is associated with intermittent hypoxia and cognitive decrements...
  57. ncbi Obesity and excessive daytime sleepiness in prepubertal children with obstructive sleep apnea
    David Gozal
    Kosair Children s Hospital Research Institute, University of Louisville School of Medicine, Louisville, KY 40202, USA
    Pediatrics 123:13-8. 2009
    ..However, it remains unclear whether obesity modifies the relative frequency of daytime symptoms such as excessive daytime sleepiness...
  58. ncbi 8-Isoprostane, a marker of oxidative stress, is increased in exhaled breath condensate of patients with obstructive sleep apnea after night and is reduced by continuous positive airway pressure therapy
    Giovanna E Carpagnano
    Institute of Respiratory Diseases, University of Bari, Bari, Italy
    Chest 124:1386-92. 2003
    b>Obstructive sleep apnea (OSA) is characterized by recurrent apnea during sleep that may compromise oxidative balance. Oxidative stress is increased in the blood and in the airways of OSA patients.
  59. ncbi A review of executive functions in obstructive sleep apnea syndrome
    T Saunamäki
    Department of Neurology and Rehabilitation, Tampere University Hospital, Tampere, Finland
    Acta Neurol Scand 115:1-11. 2007
    To provide an update on recent research concerning obstructive sleep apnea syndrome (OSAS) and executive functions.
  60. ncbi Obstructive sleep apnea in extremely overweight adolescents undergoing bariatric surgery
    Maninder Kalra
    Division of Pulmonary Medicine, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
    Obes Res 13:1175-9. 2005
    To determine the prevalence of obstructive sleep apnea (OSA) in extremely overweight adolescents and to examine the effect of significant weight loss on OSA severity.
  61. ncbi Obstructive sleep apnea and the prefrontal cortex: towards a comprehensive model linking nocturnal upper airway obstruction to daytime cognitive and behavioral deficits
    Dean W Beebe
    Division of Psychology, Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    J Sleep Res 11:1-16. 2002
    b>Obstructive sleep apnea (OSA) is accompanied by significant daytime cognitive and behavioral deficits that extend beyond the effects of sleepiness...
  62. ncbi The effects of nasal continuous positive airway pressure on platelet activation in obstructive sleep apnea syndrome
    David S Hui
    Department of Medicine and Therapeutics, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong
    Chest 125:1768-75. 2004
    A case-controlled study to assess the effects of nasal continuous positive airway pressure (CPAP) on platelet activation in patients with obstructive sleep apnea (OSAS) syndrome.
  63. pmc Impact of gender on incident diabetes mellitus in obstructive sleep apnea: a 16-year follow-up
    Yelda Turgut Celen
    Sleep Medicine Unit, Department of Neurology and Rehabilitation Medicine, Skaraborg Hospital, Skovde, Sweden
    J Clin Sleep Med 6:244-50. 2010
    To address the influence of gender and obstructive sleep apnea (OSA) on development of diabetes mellitus (DM) in a sleep clinic cohort.
  64. pmc Obstructive sleep apnea and risk of motor vehicle crash: systematic review and meta-analysis
    Stephen Tregear
    MANILA Consulting Group, McLean, VA, USA
    J Clin Sleep Med 5:573-81. 2009
    ..The primary objective involved determining whether individuals with obstructive sleep apnea (OSA) are at an increased risk for a motor vehicle crash when compared to comparable individuals who do ..
  65. ncbi Practice guidelines for the perioperative management of patients with obstructive sleep apnea: a report by the American Society of Anesthesiologists Task Force on Perioperative Management of patients with obstructive sleep apnea
    Jeffrey B Gross
    Anesthesiology 104:1081-93; quiz 1117-8. 2006
  66. ncbi Effects of obstructive sleep apnea on circulating ICAM-1, IL-8, and MCP-1
    Eijiro Ohga
    Department of Geriatric Medicine, Graduate School of Medicine, University of Tokyo, Japan
    J Appl Physiol (1985) 94:179-84. 2003
    b>Obstructive sleep apnea syndrome (OSAS) is one of the most important risk factors of cardiovascular disorders. In the treatment of OSAS, nasal continuous positive airway pressure (nCPAP) has been widely used and found to be effective...
  67. ncbi Neck circumference as a measure of central obesity: associations with metabolic syndrome and obstructive sleep apnea syndrome beyond waist circumference
    Altan Onat
    Turkish Society of Cardiology, Istanbul University, Istanbul, Turkey
    Clin Nutr 28:46-51. 2009
    To investigate the relationship of neck circumference (NC) to metabolic syndrome (MetS) and obstructive sleep apnea syndrome (OSAS) and whether it adds information to that provided by waist circumference.
  68. ncbi Obstructive sleep apnea and the recurrence of atrial fibrillation
    Ravi Kanagala
    Mayo Clinic, 200 First St SW, Rochester, Minn 55905, USA
    Circulation 107:2589-94. 2003
    We tested the hypothesis that patients with untreated obstructive sleep apnea (OSA) would be at increased risk for recurrence of atrial fibrillation (AF) after cardioversion.
  69. ncbi Prevalence of symptoms and risk of sleep apnea in the US population: Results from the national sleep foundation sleep in America 2005 poll
    David M Hiestand
    Division of Pulmonary, Critical Care, and Sleep Medicine, K528 Kentucky Clinic, University of Kentucky College of Medicine, Lexington, KY 40536 0028, USA
    Chest 130:780-6. 2006
    b>Obstructive sleep apnea (OSA) is a common medical condition with significant adverse consequences, but OSA remains undiagnosed in many individuals...
  70. ncbi Randomized placebo-controlled trial of continuous positive airway pressure on blood pressure in the sleep apnea-hypopnea syndrome
    J F Faccenda
    Respiratory Medicine Unit and Cardiovascular Unit, University of Edinburgh, Royal Infirmary, Edinburgh, Scotland, United Kingdom
    Am J Respir Crit Care Med 163:344-8. 2001
    ..38; p = 0.002). Both ESS and FOSQ domains improved. Thus, CPAP can reduce blood pressure in patients with SAHS, particularly in those with nocturnal oxygen desaturation, but the decrease is small...
  71. ncbi Validation of the Berlin questionnaire and American Society of Anesthesiologists checklist as screening tools for obstructive sleep apnea in surgical patients
    Frances Chung
    Department of Anesthesia, University of Toronto, Toronto Western Hospital, University Health Network, Toronto, Ontario, Canada
    Anesthesiology 108:822-30. 2008
    Because of the high prevalence of obstructive sleep apnea (OSA) and its adverse impact on perioperative outcome, a practical screening tool for surgical patients is required...
  72. pmc Epidemiology of pediatric obstructive sleep apnea
    Julie C Lumeng
    Center for Human Growth and Development, and Department of Pediatrics, University of Michigan, Ann Arbor, MI 48109 0406, USA
    Proc Am Thorac Soc 5:242-52. 2008
    Pediatric obstructive sleep apnea (OSA) has become widely recognized only in the last few decades as a likely cause of significant morbidity among children...
  73. ncbi Practice parameters for the treatment of snoring and Obstructive Sleep Apnea with oral appliances: an update for 2005
    Clete A Kushida
    Stanford University Center of Excellence for Sleep Disorders, CA, USA
    Sleep 29:240-3. 2006
    ..the previously published recommendations regarding use of oral appliances in the treatment of snoring and Obstructive Sleep Apnea (OSA)...
  74. pmc Endothelial progenitor cells and vascular dysfunction in children with obstructive sleep apnea
    Leila Kheirandish-Gozal
    Section of Pediatric Sleep Medicine, Department of Pediatrics, The University of Chicago, 5721 S Maryland Avenue, MC 8000, Suite K 160, Chicago, IL 60637, USA
    Am J Respir Crit Care Med 182:92-7. 2010
    Endothelial dysfunction is a potential complication of obstructive sleep apnea syndrome (OSAS) in children ascribed to systemic inflammatory changes. However, not all children with OSAS will manifest endothelial dysfunction.
  75. ncbi Lifestyle intervention with weight reduction: first-line treatment in mild obstructive sleep apnea
    Henri P I Tuomilehto
    Department of Otorhinolaryngology, Institute of Clinical Medicine, University of Kuopio, Kuopio University Hospital, P O Box 1777, FIN 70211 Kuopio, Finland
    Am J Respir Crit Care Med 179:320-7. 2009
    Obesity is the most important risk factor for obstructive sleep apnea (OSA). However, although included in clinical guidelines, no randomized controlled studies have been performed on the effects of weight reduction on mild OSA.
  76. ncbi Effect of nasal continuous positive airway pressure treatment on blood pressure in patients with obstructive sleep apnea
    Heinrich F Becker
    Department of Respiratory Medicine, Philipps University Marburg, Marburg, Germany
    Circulation 107:68-73. 2003
    There is increasing evidence that obstructive sleep apnea (OSA) is an independent risk factor for arterial hypertension...
  77. pmc Reduced brain gray matter concentration in patients with obstructive sleep apnea syndrome
    Eun Yeon Joo
    Sleep Center, Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
    Sleep 33:235-41. 2010
    To investigate differences in brain gray matter concentrations or volumes in patients with obstructive sleep apnea syndrome (OSA) and healthy volunteers.
  78. ncbi Obstructive sleep apnoea syndrome--an oxidative stress disorder
    Lena Lavie
    Anatomy and Cell Biology, Bruce Rappaport Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel
    Sleep Med Rev 7:35-51. 2003
    ..Cumulatively, these processes may exacerbate atherogenic sequelae in OSA...
  79. pmc Adult obstructive sleep apnea: pathophysiology and diagnosis
    Susheel P Patil
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, Baltimore, MD 21224, USA
    Chest 132:325-37. 2007
    b>Obstructive sleep apnea (OSA) is a highly prevalent disease characterized by recurrent episodes of upper airway obstruction that result in recurrent arousals and episodic oxyhemoglobin desaturations during sleep...
  80. pmc A randomized study on the effect of weight loss on obstructive sleep apnea among obese patients with type 2 diabetes: the Sleep AHEAD study
    Gary D Foster
    Center for Obesity Research and Education, Temple University, 3223 N Broad St, Ste 175, Philadelphia, PA 19140, USA
    Arch Intern Med 169:1619-26. 2009
    The belief that weight loss improves obstructive sleep apnea (OSA) has limited empirical support. The purpose of this 4-center study was to assess the effects of weight loss on OSA over a 1-year period.
  81. pmc The impact of obstructive sleep apnea on metabolic and inflammatory markers in consecutive patients with metabolic syndrome
    Luciano F Drager
    Heart Institute InCor, University of Sao Paulo Medical School, Sao Paulo, Brazil
    PLoS ONE 5:e12065. 2010
    b>Obstructive Sleep Apnea (OSA) is tightly linked to some components of Metabolic Syndrome (MetS)...
  82. ncbi Neuropsychological sequelae of obstructive sleep apnea-hypopnea syndrome: a critical review
    Mark S Aloia
    Brown Medical School, Providence, Rhode Island 02906, USA
    J Int Neuropsychol Soc 10:772-85. 2004
    b>Obstructive sleep apnea-hypopnea syndrome (OSAHS) is a well-recognized clinical sleep disorder that results in chronically fragmented sleep and recurrent hypoxemia...
  83. ncbi Obstructive sleep apnea and depression
    Melanie Harris
    Australasian Sleep Trials Network, Adelaide Institute for Sleep Health, Flinders University, Adelaide, Australia
    Sleep Med Rev 13:437-44. 2009
    There are high rates of depression in people with obstructive sleep apnea (OSA) in both community and clinical populations. A large community study reported a rate of 17% and reports for sleep clinic samples range between 21% and 41%...
  84. ncbi Continuous positive airway pressure treatment rapidly improves insulin sensitivity in patients with obstructive sleep apnea syndrome
    Igor A Harsch
    Department of Medicine I, Friedrich Alexander University Erlangen Nuremberg, Erlangen, Germany
    Am J Respir Crit Care Med 169:156-62. 2004
    The obstructive sleep apnea syndrome is typically associated with conditions known to increase insulin resistance as hypertension, obesity, and diabetes...
  85. ncbi Safety and efficacy of pulmonary vein antral isolation in patients with obstructive sleep apnea: the impact of continuous positive airway pressure
    Dimpi Patel
    St David s Medical Center, Austin, TX, USA
    Circ Arrhythm Electrophysiol 3:445-51. 2010
    b>Obstructive sleep apnea (OSA) may be associated with pulmonary vein antrum isolation (PVAI) failure. The aim of the present study was to investigate if treatment with continuous positive airway pressure (CPAP) improved PVAI success rates.
  86. ncbi Aortic stiffness, flow-mediated dilatation and carotid intima-media thickness in obstructive sleep apnea: non-invasive indicators of atherosclerosis
    Halil Tanriverdi
    Department of Cardiology, Pamukkale University School of Medicine, Denizli, Turkey
    Respiration 73:741-50. 2006
    b>Obstructive sleep apnea (OSA) has a critical association with cardiovascular mortality and morbidity. Carotid intima-media thickness (IMT), flow-mediated dilatation (FMD) and aortic stiffness are early signs of atherosclerosis...
  87. ncbi The efficacy of multilevel surgery of the upper airway in adults with obstructive sleep apnea/hypopnea syndrome
    Hsin Ching Lin
    Department of Otolaryngology, Chang Gung Memorial Hospital Kaohsiung Medical Center, Chang Gung University College of Medicine, Kaohsiung, Taiwan
    Laryngoscope 118:902-8. 2008
    Many patients with obstructive sleep apnea/hypopnea syndrome (OSAHS) are incapable of using continuous positive airway pressure. These patients therefore turn to surgical options as a salvage treatment...
  88. ncbi Nasal resistance for determinant factor of nasal surgery in CPAP failure patients with obstructive sleep apnea syndrome
    Seiichi Nakata
    Department of Otorhinolaryngology, Nagoya University School of Medicine, Nagoya, Japan
    Rhinology 43:296-9. 2005
    Given that criteria for nasal surgery in individuals with obstructive sleep apnea syndrome (OSAS) have not been proposed, we investigated the effectiveness of nasal surgery for CPAP failure in patients with both severe OSAS and nasal ..
  89. ncbi Validation of the modified Berlin questionnaire to identify patients at risk for the obstructive sleep apnoea syndrome
    S K Sharma
    Department of Medicine, All India Institute of Medical Sciences, New Delhi, India
    Indian J Med Res 124:281-90. 2006
    ..The present study was undertaken to test the utility of modified Berlin questionnaire for risk categorization of OSA in Indian setting...
  90. pmc Pathophysiology of adult obstructive sleep apnea
    Danny J Eckert
    Division of Sleep Medicine, Sleep Disorders Program, Brigham and Women s Hospital, and Havard Medical School, Boston, MA 02115, USA
    Proc Am Thorac Soc 5:144-53. 2008
    b>Obstructive sleep apnea (OSA) is a common disorder characterized by repetitive narrowing or collapse of the pharyngeal airway during sleep...
  91. ncbi Effect of oral appliance therapy on neurobehavioral functioning in obstructive sleep apnea: a randomized controlled trial
    Sharon L Naismith
    Department of Respiratory and Sleep Medicine, St George Hospital, The University of New South Wales, Sydney, Australia
    J Clin Sleep Med 1:374-80. 2005
    This study aimed to assess the efficacy of a custom-made mandibular advancement splint for the treatment of obstructive sleep apnea with respect to neuropsychological functioning and mood state.
  92. ncbi Obstructive sleep apnea
    Sean M Caples
    Mayo Clinic, Rochester, Minnesota, MN 55905, USA
    Ann Intern Med 142:187-97. 2005
  93. ncbi Influence of obstructive sleep apnea on mortality in patients with heart failure
    Hanqiao Wang
    Sleep Research Laboratory of the Toronto Rehabilitation Institute, Toronto, Ontario, Canada
    J Am Coll Cardiol 49:1625-31. 2007
    This study sought to determine, in patients with heart failure (HF), whether untreated moderate to severe obstructive sleep apnea (OSA) is associated with a higher mortality rate than in patients with mild to no sleep apnea (M-NSA).
  94. ncbi Inflammatory proteins in patients with obstructive sleep apnea with and without daytime sleepiness
    Mónica de la Peña Bravo
    Hospital Universitario Son Dureta, Servicio de Neumologia, Palma de Mallorca, Baleares 07014, Spain
    Sleep Breath 11:177-85. 2007
    Excessive daytime sleepiness (EDS) is one of the most frequent symptoms in patients with obstructive sleep apnea syndrome (OSAS). However, not all patients with OSAS manifest EDS...
  95. ncbi Impact of continuous positive airway pressure therapy on blood pressure in patients with obstructive sleep apnea hypopnea: a meta-analysis of randomized controlled trials
    M Alajmi
    Department of Medicine, Respiratory Division, University of British Columbia, Vancouver, British Columbia, Canada
    Lung 185:67-72. 2007
    Patients with untreated obstructive sleep apnea hypopnea (OSAH) are predisposed to developing hypertension, and therapy with continuous positive airway pressure (CPAP) may reduce blood pressure (BP)...
  96. ncbi Gender differences in obstructive sleep apnea syndrome: a clinical study of 1166 patients
    Esther Quintana-Gallego
    Department of Pneumology, Virgen del Rocio University Hospital, Seville, Spain
    Respir Med 98:984-9. 2004
    ..data between men and women in a sample of 1745 patients referred to a Sleep Unit for symptoms of obstructive sleep apnea (OSA). A standardized questionnaire was administered and anthropometric data were measured...
  97. ncbi Metabolic effects of the obstructive sleep apnea syndrome and cardiovascular risk
    Maria Rosaria Bonsignore
    Department of Medicine, Pneumology, Physiology and Nutrition, University of Palermo, Italy
    Arch Physiol Biochem 114:255-60. 2008
    The obstructive sleep apnea syndrome (OSAS) is characterized by collapse of the upper airway during sleep, recurring apneas, intermittent hypoxemia and daytime somnolence...
  98. pmc Serum aminotransferase levels are associated with markers of hypoxia in patients with obstructive sleep apnea
    Daniel Norman
    Department of Pulmonary and Critical Care Medicine, University of California at San Diego, San Diego, CA 92103 8383, USA
    Sleep 31:121-6. 2008
    ..been linked with the metabolic syndrome, recent studies suggest NAFLD may also be associated with obstructive sleep apnea (OSA)...
  99. pmc Surgical modifications of the upper airway for obstructive sleep apnea in adults: a systematic review and meta-analysis
    Sean M Caples
    Center for Sleep Medicine, Division of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester MN, USA
    Sleep 33:1396-407. 2010
    A substantial portion of patients with obstructive sleep apnea (OSA) seek alternatives to positive airway pressure (PAP), the usual first-line treatment for the disorder. One option is upper airway surgery...
  100. ncbi Comparison of cognitive performance among different age groups in patients with obstructive sleep apnea
    Manos Alchanatis
    Department of Pulmonary Medicine, University of Athens Medical School, Sotiria Hospital for Chest Diseases, Greece
    Sleep Breath 12:17-24. 2008
    The aim of this study was to evaluate the effect of obstructive sleep apnea syndrome on the cognitive performance of young and middle-aged patients...
  101. ncbi Neurocognitive and endothelial dysfunction in children with obstructive sleep apnea
    David Gozal
    Department of Pediatrics, University of Chicago, 5721 S Maryland Ave, MC 8000, Suite K 160, Chicago, IL 60637, USA
    Pediatrics 126:e1161-7. 2010
    Pediatric obstructive sleep apnea syndrome (OSAS) is associated with neurocognitive and endothelial dysfunction...

Research Grants74

  1. Cardiovascular Responses to Sleep Apnea in Tetraplegia: A Pilot Study
    Jill M Wecht; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Screening studies suggest that the prevalence of moderate to severe obstructive sleep apnea (OSA) in persons with tetraplegia ranges from 22% to 36%, thus greatly exceeding prevalence estimates of 9...
  2. Effective treatment of sleep apnea in prediabetes to reduce cardiometabolic risk
    Esra Tasali; Fiscal Year: 2010
    ..Prediabetic state is a major risk factor for cardiovascular disease and progression to overt diabetes. Obstructive sleep apnea (OSA) is a treatable sleep disorder that is pervasive among overweight and obese individuals...
  3. ORGANIZATION OF CENTRAL SYMPATHETIC PATHWAYS
    Patrice G Guyenet; Fiscal Year: 2013
    ..These mechanisms are implicated in many human diseases or conditions such as obstructive sleep apnea (OSA), the treatment of pain with opiates, central sleep apnea, sudden infant death syndrome (SIDS), and ..
  4. Chronic nicotine and synaptic transmission in brainstem respiratory neurons
    RALPH FRANK FREGOSI; Fiscal Year: 2013
    ..document that the main respiratory phenotype in nicotine-exposed human neonates is a higher incidence of obstructive sleep apnea. It is widely accepted that obstructive apnea is caused largely by abnormal activation of tongue muscles, ..
  5. INTERNET ENHANCED HEALTH PROMOTION FOR OBESE ETHNIC MINORITY ADOLESCENTS
    Jessica A Whiteley; Fiscal Year: 2011
    ..are increasingly seen in obese youth, including insulin resistance, type 2 diabetes, hypertension, obstructive sleep apnea, poor self-esteem, lower health-related quality of life (Rashid &Roberts, 2000;Rosenbloom, 2002;Sorof,..
  6. ECG-derived cardiopulmonary coupling biomarkers of sleep, sleep-breathing, and ca
    Robert J Thomas; Fiscal Year: 2010
    ..2) Heightened respiratory chemoreflexes may contribute to obstructive sleep apnea severity, be associated with induction of central apneas when continuous positive airway pressure (CPAP) ..
  7. Respiratory and autonomic plasticity following intermittent hypoxia
    JASON HAROLD MATEIKA; Fiscal Year: 2012
    ..established in animals it has not been observed consistently in healthy humans or in individuals with obstructive sleep apnea. Similarly, although a few studies have shown that exposure to IH leads to increases in SNSA in healthy ..
  8. Pharmacologic Interventions for Cardiovascular Disease in Obstructive Sleep Apnea
    Barbara J Morgan; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Obstructive sleep apnea (OSA), a relatively common condition that causes nightly exposure to intermittent hypoxia, has emerged as a risk factor for hypertension;however, the underlying mechanisms are ..
  9. Evaluation of obstructive sleep apnea with long range 3D endoscopic FDOCT
    Jun Zhang; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Obstructive sleep apnea (OSA) is a major medical problem that affects 18-20 million people in the United States...
  10. The Impact of Obstructive Sleep Apnea on Non-Alcoholic Fatty Liver Disease
    KATHLEEN ELIZABETH COREY; Fiscal Year: 2013
    ..In addition, her recent study assessing protective factors for the development of NAFLD, she found that obstructive sleep apnea (OSA) was one of the strongest predictors of normal liver histology in patients with obesity, suggesting ..
  11. Non-Alcoholic Fatty Liver Disease and Obstructive Sleep Apnea: Mechanistic Links
    SHIKHA SEKSARIA SUNDARAM; Fiscal Year: 2013
    ..Recent evidence indicates a potential link between NASH and obstructive sleep apnea (OSA), both common co-morbidities of obesity...
  12. Mechanisms and Consequences of Intermittent Hypoxia-Induced Lipolysis
    Jonathan C Jun; Fiscal Year: 2013
    ..Polotsky, a pioneer in the use of intermittent hypoxia (IH) in mice to study metabolic consequences of obstructive sleep apnea (OSA). In this proposal, Dr. Jun tests a novel theory to explain the metabolic dysfunction induced by IH...
  13. Predictors of sleep-dependent Memory Consolidation in Obstructive Sleep Apnea
    Ina E Djonlagic; Fiscal Year: 2013
    ..Ultimately, this research has the opportunity to provide critical information that may in due course alter how sleep apnea is defined and thus provide a major impact on the care of sleep apnea patients. ..
  14. Mechanisms and consequences of sleep disordered breathing in COPD
    Cynthia D Brown; Fiscal Year: 2012
    ..Even in the absence of obstructive sleep apnea, sleep fragmentation and gas exchange abnormalities are common in COPD with consequent complaints of ..
  15. Plasticity of nTS output neurons in acute and chronic hypoxia
    DAVID DOUGLAS KLINE; Fiscal Year: 2013
    ..low arterial oxygen (hypoxia) and participates in physiological adaptations and in disease states such as obstructive sleep apnea (OSA)...
  16. The Role of Lung Volumes in Nocturnal Asthma
    ROBERT LLEWELLYN OWENS; Fiscal Year: 2013
    ..influence of lung volumes on upper airway collapsibility, and helps explain the role of lung volumes in obstructive sleep apnea. Completion of the project required careful measurements made during sleep using techniques perfected in ..
  17. Purinergic signaling in sleep apnea
    Elzbieta Kaczmarek; Fiscal Year: 2012
    b>Obstructive sleep apnea (OSA) is a breathing disorder that affects at least 4% of the adult population...
  18. NEUROPHYSIOLOGY OF PARASYMPATHETIC CARDIAC NEURONS
    David Mendelowitz; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Obstructive Sleep Apnea (OSA) is a significant health risk occurring in as many as 24% of adult males and 9% of adult females within the United States population...
  19. Sleep Apnea and Dysregulation of Lipid Metabolism
    Vsevolod Y Polotsky; Fiscal Year: 2013
    b>Obstructive sleep apnea (OSA) leads to high cardiovascular mortality, which has been attributed to metabolic abnormalities induced by chronic intermittent hypoxia (IH)...
  20. A randomized trial of bariatric surgery for the treatment of sleep apnea
    Sanjay R Patel; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Obstructive sleep apnea (OSA) is one of the most common complications of obesity, resulting in excessive sleepiness and daytime functional impairment...
  21. Neuroanatomical and functional outcomes of pediatric obstructive sleep apnea
    Robert Joseph Thomas; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Pediatric obstructive sleep apnea (OSA) is associated with impaired executive function, and manifests clinically as impairments in learning, attention, memory, and school performance, along with ..
  22. Crosslink augmentation to resist snoring and obstructive sleep apnea syndrome
    Thomas P Hedman; Fiscal Year: 2013
    ..lead to sleep-deprivation in the sufferer and to a more serious and sometimes life-threatening condition, obstructive sleep apnea syndrome (OSAS), where breathing is interrupted during sleep by physical obstruction of the airway...
  23. Oxidative stress in a murine model of sleep apnea
    David Gozal; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Obstructive sleep apnea syndrome (OSAS), the most severe form of sleep disordered breathing (SDB), is a condition characterized by repeated episodes of intermittent hypoxia (IH) that frequently ..
  24. Interfacing Adiposity, Sleep Apnea, and Insulin Resistance
    Alice Liu; Fiscal Year: 2013
    ..Recently, attention has shifted to evaluating the relationship between obstructive sleep apnea (OSA) and T2DM...
  25. Perioperative Use and Outcomes of Noninvasive Ventilation in Sleep Apnea
    Peter K Lindenauer; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Obstructive sleep apnea (OSA) is a common disorder characterized by repetitive, complete, or partial collapse of the upper airway during sleep that affects at least 9% of middle-aged women and 24% of ..
  26. Intermittent hypoxia, adiponectin, and insulin resistance in cardiovascular risk
    NARASIMHAM LAXMI PARINANDI; Fiscal Year: 2013
    ..an important factor in the development of insulin resistance and cardiovascular diseases in patients with obstructive sleep apnea (OSA). OSA is very common in congestive heart failure (CHF) occurring in up to a third of patients...
  27. An RCT of telemedicine interventions for OSA
    DAVID W SPARROW; Fiscal Year: 2013
    Project Background/Rationale. Obstructive sleep apnea/hypopnea (OSAH) is a common chronic disease that is associated with daytime sleepiness, impaired health-related quality of life (QOL), and increased risk of hypertension and ..
  28. Prediction of Physiological Events in People with Sleep Disordered Breathing
    Jonathan A Waxman; Fiscal Year: 2011
    ..The most common is obstructive sleep apnea (OSA)...
  29. Aging, Sleep Apnea, and Vascular Control During Systemic Hypoxia
    Frank A Dinenno; Fiscal Year: 2013
    ..function declines progressively with advancing age in humans, and is further impaired in patients with obstructive sleep apnea (OSA), increasing the risk for atherosclerotic and ischemic vascular disease...
  30. Mechanisms of respiratory long-term facilitation
    Gordon S Mitchell; Fiscal Year: 2013
    ..guide the development of novel therapeutic strategies for severe ventilatory control disorders, including obstructive sleep apnea and respiratory insufficiency in patients with spinal injury or motor neuron disease (ALS)...
  31. Impact of Sleep in the Restoring Insulin Secretion (RISE) Study
    Babak Mokhlesi; Fiscal Year: 2013
    ..The prevalence of obstructive sleep apnea (OSA) in the general population has also increased rapidly and dramatically, in parallel with the ..
  32. PHASE II TRIAL OF SLEEP APNEA TREATMENT TO REDUCE CARDIOVASCULAR MORBIDITY
    SUSAN S REDLINE; Fiscal Year: 2010
    ..b>Obstructive sleep apnea (OSA) afflicts >5% of adults and is associated with a 2 to 4-fold increased risk of cardiovascular ..
  33. Long-term effects of caffeine therapy for apnea of prematurity on sleep disorders
    Carole L Marcus; Fiscal Year: 2012
    ..and ventilatory control, resulting in an increased prevalence of sleep disorders such as insomnia and the obstructive sleep apnea syndrome (OSAS)...
  34. Randomized Controlled Study of Adenotonsillectomy for Childhood Sleep Apnea
    SUSAN S REDLINE; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Pediatric obstructive sleep apnea (OSA) is a prevalent disorder, with a high burden among minority children...
  35. Impaired Sleep, Insulin Action, and Overweight in Youth
    Tamara S Hannon; Fiscal Year: 2010
    ..or equal to the 95th percentile) often snore, have symptoms of poor sleep, and are at higher risk for obstructive sleep apnea (OSA) as well as other health conditions than lean youth...
  36. An objective snoring index and its association with carotid atherosclerosis
    JinYoung Kim; Fiscal Year: 2013
    ..of severity of sleep-related breathing disorders, snoring is at the mildest end of the spectrum of which obstructive sleep apnea (OSA) is at the more severe end...
  37. The Overlap Syndrome of COPD and OSA: Determinants of Health Status and Outcomes
    Theodore A Omachi; Fiscal Year: 2012
    ..clinical investigator of the overlap syndrome of chronic obstructive pulmonary disease (COPD) and obstructive sleep apnea (OSA)...
  38. Obstructive Sleep Apnea in WTC Responders: Role of Nasal Pathology
    Jag Sunderram; Fiscal Year: 2013
    ..snoring on their questionnaires immediately following their exposure and had unusually high prevalence of obstructive sleep apnea (OSA) that did not appear to be related to obesity, which is the usual risk factor for OSA...
  39. Obstructive Sleep Apnea, Gender Biology, and Autonomic Regulation
    PAUL MICHAEL MACEY; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Obstructive sleep apnea (OSA) occurs in close to 20% of men and 10% of women in the adult population, and is an independent risk factor for cardiovascular disease and death...
  40. Prognosis and Determinants of Asthma Morbidity in World Trade Center Rescue and R
    Juan P Wisnivesky; Fiscal Year: 2013
    ..and impact of upper airway conditions (rhinitis, sinusitis), gatroesophageal reflux disease (GERD), and obstructive sleep apnea (OSA) on asthma morbidity (control and quality of life) in WTC rescue and recovery workers;3) assess the ..
  41. An objective snoring index and its association with carotid atherosclerosis
    JinYoung Kim; Fiscal Year: 2012
    ..of severity of sleep-related breathing disorders, snoring is at the mildest end of the spectrum of which obstructive sleep apnea (OSA) is at the more severe end...
  42. Reversibility of Cardiovascular Injury with CPAP Use: Mechanisms Involved
    Claudia E Korcarz; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The prevalence of Obstructive Sleep Apnea (OSA) in middle-aged adults is at least 4% in males and 2% in females and will probably increase with the obesity epidemic in this country...
  43. MIF-Thyroxine Interactions in the Pathogenesis of Pulmonary Arterial Hypertension
    Edmund J Miller; Fiscal Year: 2013
    ..PAH, data achieved in the study will be directly relevant to other cardiopulmonary disease states in which MIF is increased including stroke, cardiovascular disease, myocardial infarction, pulmonary fibrosis and obstructive sleep apnea.
  44. Quantification of the State-Dependent Inputs to Hypoglossal Motoneurons
    VICTOR BORISOVICH FENIK; Fiscal Year: 2010
    b>Obstructive Sleep Apnea (OSA) affects about 4% of men and 2% of women of adult population...
  45. A randomized cross over trial of two treatments for OSA in Veterans with PTSD
    ALI ALBERT EL SOLH; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Obstructive sleep apnea (OSA) is a prevalent disorder associated with poor neurocognitive performance and organ system dysfunction due to intermittent hypoxia and repeated arousals...
  46. Carotid afferent and parafacial neuronal excitatory effects on breathing
    Hubert V Forster; Fiscal Year: 2013
    ..respiratory rhythmogenic neurons during sleep;hence, dysfunction of Phox2b+ neurons underlies central and obstructive sleep apnea, and abnormal chemoreceptor and exerciseventilatory responses...
  47. Upper airway control during disrupted and misaligned sleep
    LESZEK K KUBIN; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Obstructive sleep apnea syndrome (OSA) affects about 5% of adults and has severe adverse consequences for many regulatory systems (cardiovascular, metabolic, cognitive)...
  48. TMS in the Management of Postoperative Pain
    Jeffrey J Borckardt; Fiscal Year: 2010
    ..particularly problematic in gastric-bypass surgery patients who tend to have respiratory problems (like obstructive sleep apnea), right ventricular dysfunction, pulmonary hypertension, and for whom post-operative vomiting could ..
  49. PREMOTOR CONTROL OF UPPER AIRWAY AND REM SLEEP ATONIA
    LESZEK K KUBIN; Fiscal Year: 2012
    About 5% of adults suffer from the obstructive sleep apnea syndrome (OSAS). OSAS patients have predisposing upper airway anatomy that requires increased levels of activity in those muscles that maintain the upper airway open...
  50. Intermittent Hypoxia: A Model to Study Circulatory Control in Humans
    Urs A Leuenberger; Fiscal Year: 2012
    ..is common in a variety of disease states and in smokers, and intermittent hypoxia is characteristic of obstructive sleep apnea. These conditions are marked by increased cardiovascular risk...
  51. Neurobiological Mechanisms of Sympathetic Regulation in Sleep Apnea
    Anne M Fink; Fiscal Year: 2013
    ..the significant and independent risk for cardiovascular (CV) morbidity/mortality resulting from obstructive sleep apnea (OSA)...
  52. Role of the PVN in Chronic Intermittent Hypoxia-Induced Cardiorespiratory Changes
    Prabha Kc; Fiscal Year: 2012
    b>Obstructive sleep apnea, nocturnal asthma, and cardiovascular disorders are associated with repeated hypoxic episodes or chronic intermittent hypoxia (CIH), that In turn, cause post-hypoxic changes associated with long-term facilitation (..
  53. Targeted Therapies for Selected Phenotypes of Obstructive Sleep Apnea
    Jerome A Dempsey; Fiscal Year: 2010
    ..Area (05) Comparative Effectiveness Research and specific Challenge Topic (05-HL-102) Treatment of Obstructive Sleep Apnea. About 15-30% of obstructive sleep apnea (OSA) patients have a poor tolerance for nasally-applied ..
  54. Vascular Endothelial Activation in Sleep Apnea
    Sanja Jelic; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Obstructive sleep apnea (OSA), a condition that affects a quarter of American adults, is strongly and independently associated with an increased risk for cardiovascular diseases and increased all-..
  55. The Effect of Treatment of OSA on Diabetes Self Management and Glycemic Control
    Eileen R Chasens; Fiscal Year: 2013
    ..b>Obstructive sleep apnea (OSA) has a high prevalence among adults with type 2 diabetes (T2DM) and is associated with excessive ..
  56. CSF and the central chemical control of breathing.
    Eugene Edward Nattie; Fiscal Year: 2013
    ..Chemoreception is of particular importance in the stimulation of breathing and arousal during obstructive sleep apnea and in the breathing instability that may follow...
  57. Mechanisms and Effectiveness of Weight Loss Methods on Diabetes and Sleep Apnea
    Jeanne M Clark; Fiscal Year: 2012
    ..To be eligible, patients must have type 2 diabetes (T2DM) and obstructive sleep apnea (OSA), chosen because they are associated with very high risk for cardiovascular complications and ..
  58. Retrotrapezoid nucleus and central chemoreception
    Patrice G Guyenet; Fiscal Year: 2013
    ..have considerable clinical relevance for congenital central hypoventilation syndrome (CCHS), central and obstructive sleep apnea (OSA), sudden infant death syndrome (SIDS) and the treatment of pain with opiates...
  59. Positive Airway Pressure Gas Modulator - A Novel Method to Treat Central Sleep Ap
    HANI AKRAM KAYYALI; Fiscal Year: 2011
    ..Sleep apnea is a major public health problem but traditional treatments have focused mostly on resolving obstructive sleep apnea (OSA) as demonstrated by the plethora of obstruction-motivated therapies like positive airway pressure, ..
  60. Enhancing Motivation for CPAP Adherence in Obstructive Sleep Apnea
    Faith S Luyster; Fiscal Year: 2013
    ..Continuous positive airway pressure (CPAP) therapy is an effective treatment for obstructive sleep apnea (OSA), but adherence is poor...
  61. Predicting Obstructive Sleep Apnea in Down Syndrome
    BRIAN GARY SKOTKO; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Obstructive sleep apnea (OSA) in individuals with Down syndrome is associated with multiple morbidities: systemic and pulmonary hypertension, glucose intolerance, cardiovascular and cerebrovascular ..
  62. Intermittent Hypoxia-Induced Inflammation Modulates Respiratory Plasticity
    Jyoti J Watters; Fiscal Year: 2013
    ..pathologies, including chronic lung disease, traumatic, ischemic and degenerative neural disorders, and obstructive sleep apnea. We propose to investigate mechanisms whereby inflammation impairs a well-studied model of respiratory ..
  63. CHEMOSENSITIVITY, UPPER AIRWAY--BREATHING
    Kevin Gleeson; Fiscal Year: 1991
    ..Similar studies are planned for patients with mild to moderate obstructive sleep apnea to determine if these manipulations change the frequency of spontaneous apnea...
  64. Effects of Treating Obstructive Sleep Apnea in Epilepsy
    Beth Malow; Fiscal Year: 2004
    ..One approach to improving seizure control is to treat coexisting sleep disorders, such as obstructive sleep apnea. Obstructive sleep apnea (OSA) may exacerbate seizures via sleep fragmentation, sleep deprivation, or ..
  65. Nighttime Acoustic Pharyngometer (NAP) for Airway Obstruction Identification
    HANI KAYYALI; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): The ability to define the location of airway obstructions in Obstructive Sleep Apnea (OSA) patients is critical for surgical and oral appliance treatments because these therapies target the ..
  66. Sleep in Cardiac patients with Implantable Cardioverter Defibrillators (ICD)
    CHRISTINA MCCRAE; Fiscal Year: 2009
    ..b>Obstructive sleep apnea (OSA) and insomnia are likely to be the two most common sleep disorders in ICD patients...
  67. SLEEP INFLUENCE ON THE PHARYNX AND VENTILATORY CONTROL
    Clifford Zwillich; Fiscal Year: 1993
    b>Obstructive sleep apnea is a disorder whose pathogenesis remains poorly understood...
  68. Family Linkage Study of Obstructive Sleep Apnea
    Allan Pack; Fiscal Year: 2007
    DESCRIPTION: (provided by applicant) There is family aggregation of obstructive sleep apnea (OSA) as has been shown in the United States, Europe and recently in Iceland. Iceland represents a unique opportunity for genetic research...
  69. MICROINVASIVE TREATMENT OF SLEEP APNEA WITH THE LINGUAFLEX TISSUE RETRACTOR II
    Ira Sanders; Fiscal Year: 2010
    ..b>Obstructive sleep apnea (OSA) is a common disorder with high morbidity and mortality...
  70. OBSTRUCTIVE SLEEP APNEA & PERIODIC BREATHING IN SLEEP
    JOHN REMMERS; Fiscal Year: 1991
    ..These sleep-induced changes underlie the increase in pharyngeal resistance in normals and patients with obstructive sleep apnea, and they are responsible for periodic breathing in hypoxic normals and patients with central apnea...
  71. CARDIORESPIRATORY TRANSFER IN OBSTRUCTIVE SLEEP APNEA
    MICHAEL KHOO; Fiscal Year: 2000
    ..The first is to quantify the dynamic effects of respiration on heart rate control in subjects with obstructive sleep apnea syndrome (OSAS) during wakefulness and sleep...
  72. PUPILLOMETRIC SLEEPINESS IN TREATED SLEEP DISORDERS
    Joan Shaver; Fiscal Year: 2003
    Patients with obstructive sleep apnea and narcolepsy can experience a diminished quality of life, decreased productivity, and workplace and traffic accidents due to the pathologic excessive daytime sleepiness (EDS) associated with these ..
  73. Enabling Sleep Apnea Patient-Centered Care Via an Internet Intervention
    Carl Stepnowsky; Fiscal Year: 2009
    ..this proposal is to examine the effect of a novel interoperable ?internet intervention? for patients with Obstructive Sleep Apnea syndrome (OSA) that integrates a telemetry treatment device and an internet-based portal that facilitates ..
  74. Gender Differences in Neural Deficits Associated with Obstructive Sleep Apnea
    PAUL MICHAEL MACEY; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Obstructive sleep apnea (OSA) afflicts 20 million adults in the United States, and is associated with increased morbidity and mortality...