pleural effusion

Summary

Summary: Presence of fluid in the pleural cavity resulting from excessive transudation or exudation from the pleural surfaces. It is a sign of disease and not a diagnosis in itself.

Top Publications

  1. ncbi Metalloproteinases and tissue inhibitors of metalloproteinases in exudative pleural effusions
    D Iglesias
    Dept of Internal Medicine, Hospital Vall d Hebron, Barcelona, Spain
    Eur Respir J 25:104-9. 2005
  2. ncbi Diagnostic value of interferon-gamma in tuberculous pleurisy: a metaanalysis
    Jing Jiang
    Institute of Respiratory Diseases, First Affiliated Hospital, Guangxi Medical University, Nanning 530021, Guangxi, People s Republic of China
    Chest 131:1133-41. 2007
  3. ncbi Tuberculous pleural effusion
    Jose M Porcel
    Department of Internal Medicine, Pleural Diseases Unit, Arnau de Vilanova University Hospital, Institut de Recerca Biomèdica de Lleida IRBLleida, Avda Alcalde Rovira Roure 80, 25198, Lleida, Spain
    Lung 187:263-70. 2009
  4. ncbi Diagnosis and treatment of tuberculous pleural effusion in 2006
    Arun Gopi
    Division of Pulmonary, Critical Care, Allergy and Sleep Medicine, Medical University of South Carolina, Jonathan Lucas St, Suite 812 CSB, PO Box 250360, Charleston, SC 29426, USA
    Chest 131:880-9. 2007
  5. ncbi Diagnostic accuracy of adenosine deaminase in tuberculous pleurisy: a meta-analysis
    Qiu Li Liang
    Institute of Respiratory Diseases, First Affiliated Hospital, Guangxi Medical University, Nanning, 530021 Guangxi, People s Republic of China
    Respir Med 102:744-54. 2008
  6. ncbi Clinical practice. Pleural effusion
    Richard W Light
    Pulmonary Disease Program, St Thomas Hospital, and the Department of Medicine, Vanderbilt University School of Medicine, Nashville 37205, USA
    N Engl J Med 346:1971-7. 2002
  7. ncbi Update on tuberculous pleural effusion
    Richard W Light
    Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University, Nashville, Tennessee 37232 2650, USA
    Respirology 15:451-8. 2010
  8. ncbi Clinical impact and reliability of pleural fluid mesothelin in undiagnosed pleural effusions
    Helen E Davies
    Oxford Centre for Respiratory Medicine, University of Oxford, Oxford, UK
    Am J Respir Crit Care Med 180:437-44. 2009
  9. ncbi Exposure to nanoparticles is related to pleural effusion, pulmonary fibrosis and granuloma
    Y Song
    Dept of Occupational Medicine, Beijing Chaoyang Hospital, Capital University of Medical Sciences, China
    Eur Respir J 34:559-67. 2009
  10. ncbi Ultrasound estimation of volume of pleural fluid in mechanically ventilated patients
    M Balik
    Department of Intensive Care, Westmead Hospital, Westmead, Australia
    Intensive Care Med 32:318-21. 2006

Research Grants

  1. TGF-BETA FOR PLEURODESIS
    Kirk Lane; Fiscal Year: 2005
  2. Regulation of KSHV Latency
    Paul M Lieberman; Fiscal Year: 2013
  3. Advancing a Lead Candidate Hantavirus Pulmonary Syndrome DNA Vaccine
    JAY WILLIAMS HOOPER; Fiscal Year: 2013
  4. Assay Development for Inhibitors of KSHV
    Paul M Lieberman; Fiscal Year: 2010
  5. Conference Support for International Congress on Oncogenic Herpesviruses
    Paul M Lieberman; Fiscal Year: 2012
  6. KSHV genome modification in KS tissue
    Erle S Robertson; Fiscal Year: 2013
  7. The Audible Human Project
    Thomas J Royston; Fiscal Year: 2013
  8. Genome Persistence of KSHV
    Erle S Robertson; Fiscal Year: 2013
  9. Early Events in KSVH Infection of Primary B-cells
    Erle S Robertson; Fiscal Year: 2013
  10. KSHV vaccine development
    Jae U Jung; Fiscal Year: 2013

Detail Information

Publications292 found, 100 shown here

  1. ncbi Metalloproteinases and tissue inhibitors of metalloproteinases in exudative pleural effusions
    D Iglesias
    Dept of Internal Medicine, Hospital Vall d Hebron, Barcelona, Spain
    Eur Respir J 25:104-9. 2005
    ..In conclusion, elevated metalloproteinase-1, -8 and -9 expression was found in parapneumonic pleural effusions. These metalloproteinases could be implicated in the local inflammatory response existing in this group of effusions...
  2. ncbi Diagnostic value of interferon-gamma in tuberculous pleurisy: a metaanalysis
    Jing Jiang
    Institute of Respiratory Diseases, First Affiliated Hospital, Guangxi Medical University, Nanning 530021, Guangxi, People s Republic of China
    Chest 131:1133-41. 2007
    ..We conducted a metaanalysis to determine the accuracy of IFN-gamma measurements in the diagnosis of tuberculous pleurisy...
  3. ncbi Tuberculous pleural effusion
    Jose M Porcel
    Department of Internal Medicine, Pleural Diseases Unit, Arnau de Vilanova University Hospital, Institut de Recerca Biomèdica de Lleida IRBLleida, Avda Alcalde Rovira Roure 80, 25198, Lleida, Spain
    Lung 187:263-70. 2009
    Tuberculous pleural effusion is one of the most common forms of extrapulmonary tuberculosis (TB). The immediate cause of the effusion is a delayed hypersensitivity response to mycobacterial antigens in the pleural space...
  4. ncbi Diagnosis and treatment of tuberculous pleural effusion in 2006
    Arun Gopi
    Division of Pulmonary, Critical Care, Allergy and Sleep Medicine, Medical University of South Carolina, Jonathan Lucas St, Suite 812 CSB, PO Box 250360, Charleston, SC 29426, USA
    Chest 131:880-9. 2007
    Tuberculous (TB) pleural effusion occurs in approximately 5% of patients with Mycobacterium tuberculosis infection...
  5. ncbi Diagnostic accuracy of adenosine deaminase in tuberculous pleurisy: a meta-analysis
    Qiu Li Liang
    Institute of Respiratory Diseases, First Affiliated Hospital, Guangxi Medical University, Nanning, 530021 Guangxi, People s Republic of China
    Respir Med 102:744-54. 2008
    ..We conducted a meta-analysis to determine the accuracy of ADA measurements in the diagnosis of tuberculous pleurisy...
  6. ncbi Clinical practice. Pleural effusion
    Richard W Light
    Pulmonary Disease Program, St Thomas Hospital, and the Department of Medicine, Vanderbilt University School of Medicine, Nashville 37205, USA
    N Engl J Med 346:1971-7. 2002
  7. ncbi Update on tuberculous pleural effusion
    Richard W Light
    Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University, Nashville, Tennessee 37232 2650, USA
    Respirology 15:451-8. 2010
    The possibility of tuberculous pleuritis should be considered in every patient with an undiagnosed pleural effusion, for if this diagnosis is not made the patient will recover only to have a high likelihood of subsequently developing ..
  8. ncbi Clinical impact and reliability of pleural fluid mesothelin in undiagnosed pleural effusions
    Helen E Davies
    Oxford Centre for Respiratory Medicine, University of Oxford, Oxford, UK
    Am J Respir Crit Care Med 180:437-44. 2009
    ....
  9. ncbi Exposure to nanoparticles is related to pleural effusion, pulmonary fibrosis and granuloma
    Y Song
    Dept of Occupational Medicine, Beijing Chaoyang Hospital, Capital University of Medical Sciences, China
    Eur Respir J 34:559-67. 2009
    ..These cases arouse concern that long-term exposure to some nanoparticles without protective measures may be related to serious damage to human lungs...
  10. ncbi Ultrasound estimation of volume of pleural fluid in mechanically ventilated patients
    M Balik
    Department of Intensive Care, Westmead Hospital, Westmead, Australia
    Intensive Care Med 32:318-21. 2006
    The aim was to develop a practical method for estimation of the volume of pleural effusion using ultrasonography in mechanically ventilated patients.
  11. ncbi microRNA detection in feces, sputum, pleural effusion and urine: novel tools for cancer screening (Review)
    Yü Feng Xiao
    Department of Gastroenterology, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, PR China
    Oncol Rep 30:535-44. 2013
    ..In the present review, we focused mainly on the application of detecting miRNAs in stool, sputum, pleural effusion and urine, to detect colon, lung and urological cancers, highlighting the role of miRNAs in early diagnosis ..
  12. pmc Pneumococcal serotypes causing pneumonia with pleural effusion in pediatric patients
    Jigui Yu
    Department of Pathology, University of Alabama at Birmingham, BBRB 614, 1530 Third Avenue South, Birmingham, AL 35294 2170, USA
    J Clin Microbiol 49:534-8. 2011
    To determine the prevalence of serotypes of Streptococcus pneumoniae responsible for pneumonia with pleural effusion, we determined the capsular polysaccharide (PS) type directly on 49 pleural fluid specimens collected from pediatric ..
  13. ncbi Pleural effusion VEGF levels as a prognostic factor of malignant pleural mesothelioma
    Noriko Hirayama
    Division of Respiratory Medicine, Department of Internal Medicine, Hyogo College of Medicine, 1 1 Mukogawa cho, Nishinomiya, Hyogo 663 8501, Japan
    Respir Med 105:137-42. 2011
    ..Here, we investigated the pleural effusion VEGF levels in patients with MPM and compared them to those of a population with a non-malignant pleuritis or ..
  14. ncbi Increased frequencies of T helper type 17 cells in tuberculous pleural effusion
    Tingting Wang
    Immunology and Reproduction Biology Lab, Medical School and State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210093, China
    Tuberculosis (Edinb) 91:231-7. 2011
    ..This study was designed to investigate the possible involvement of Th17 cells in tuberculous pleural effusion. Compared with healthy volunteers, patients with TB had a higher proportion of Th17 cells in peripheral blood ..
  15. ncbi Diagnosis of pleural effusion: a systematic approach
    Emmet E McGrath
    Department of Respiratory Medicine, Northern General Hospital, Sheffield, England, UK
    Am J Crit Care 20:119-27; quiz 128. 2011
    In most diseases related to pleural effusion, the fluid analysis yields important diagnostic information, and in certain cases, fluid analysis alone is enough for diagnosis...
  16. pmc Multivariate modelling with (1)H NMR of pleural effusion in murine cerebral malaria
    Soumita Ghosh
    Department of Chemical Sciences, Tata Institute of Fundamental Research, Mumbai, India
    Malar J 10:330. 2011
    ..complication of cerebral malaria (CM), respiratory distress, acute lung injury, hydrothorax/pleural effusion are also observed in several cases...
  17. ncbi Getting the most from pleural fluid analysis
    Steven A Sahn
    Division of Pulmonary, Critical Care, Allergy and Sleep Medicine, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    Respirology 17:270-7. 2012
    Virtually, every pulmonary disease and most non-pulmonary diseases may be associated with a pleural effusion. The presence of a pleural effusion allows the clinician to 'diagnose' or narrow the differential diagnosis and aetiology of the ..
  18. ncbi CD4(+)CD25(+)FoxP3(+) regulatory T cells suppress Mycobacterium tuberculosis immunity in patients with active disease
    Xinchun Chen
    Shenzhen Donghu Hospital, 2019, Buxin Road, Shenzhen 518020, China
    Clin Immunol 123:50-9. 2007
    ..Therefore, CD4(+)CD25(+)FoxP3(+) Treg expanded in TB patients suppress M. tuberculosis immunity and may therefore contribute to the pathogenesis of human TB...
  19. ncbi Immunological mechanisms in pleural disease
    V B Antony
    Indiana University School of Medicine, Pulmonary and Critical Care Medicine, RL Roudebush VA Medical Center, 1481 West 10th Street, Indianapolis, IN 46202, USA
    Eur Respir J 21:539-44. 2003
    ..Immunological responses in the pleura include the development of pleural permeability and pleural effusion formation as well as the development of pleural fibrosis and scarring...
  20. ncbi [Prospective study of 1,000 consecutive patients with pleural effusion. Etiology of the effusion and characteristics of the patients]
    V Villena
    Servicio de Neumologia, Hospital Universitario 12 de Octubre, Madrid, Spain
    Arch Bronconeumol 38:21-6. 2002
    To describe the characteristics of patients with pleural effusion (PE) and the causes of PE in a prospective, consecutive series of patients.
  21. ncbi Frequent epidermal growth factor receptor gene mutations in malignant pleural effusion of lung adenocarcinoma
    S G Wu
    Dept of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan
    Eur Respir J 32:924-30. 2008
    ..Epidermal growth factor receptor tyrosine kinase inhibitors may be the treatment of choice for lung adenocarcinoma with malignant pleural effusions in east Asia...
  22. pmc Distinct cytokine and regulatory T cell profile at pleural sites of dual HIV/tuberculosis infection compared to that in the systemic circulation
    Z Toossi
    Division of Infectious Diseases, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106 4984, USA
    Clin Exp Immunol 163:333-8. 2011
    ..A correlation in expansion of T(reg) with proinflammatory cytokines (IL-6 and IL-8) in pleural fluid was shown. T(reg) themselves may promote the inflammatory cytokine milieu through IL-8...
  23. ncbi Pleural fluid interferon-gamma and adenosine deaminase levels in tuberculosis pleural effusion: a cost-effectiveness analysis
    S K Sharma
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, All India Institute of Medical Sciences, New Delhi, India
    J Clin Lab Anal 19:40-6. 2005
    ..A total of 52 patients with pleural effusion, 35 of which were found to have TB etiology, were prospectively included for estimation of ADA and IFN-gamma ..
  24. ncbi Ex vivo characterization of early secretory antigenic target 6-specific T cells at sites of active disease in pleural tuberculosis
    Katalin A Wilkinson
    Nuffield Department of Medicine, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom
    Clin Infect Dis 40:184-7. 2005
    ..The recruitment of ESAT-6-specific T cells to inflamed tuberculous tissue demonstrates their function in vivo and suggests a novel way to diagnose tuberculous pleuritis...
  25. ncbi FoxP3+ regulatory T cells suppress effector T-cell function at pathologic site in miliary tuberculosis
    Prabhat K Sharma
    Department of Transplant Immunology and Immunogenetics, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110029, India
    Am J Respir Crit Care Med 179:1061-70. 2009
    ..we studied the frequency and function of Treg cells derived from the local disease site specimens (LDSS) of patients with TB pleural effusion and MTB as clinical models of contained and disseminated forms of disease, respectively.
  26. pmc BTS guidelines for the management of pleural infection in children
    I M Balfour-Lynn
    Consultant in Paediatric Respiratory Medicine, Royal Brompton Hospital, Syndey St, SW3 6NP London, UK
    Thorax 60:i1-21. 2005
  27. ncbi Lung abnormalities after dasatinib treatment for chronic myeloid leukemia: a case series
    Anne Bergeron
    Universite Denis Diderot Paris 7, Assistance Publique Hopitaux de Paris, Service de Pneumologie, Hopital Saint Louis 1, avenue Claude Vellefaux, 75475 Paris, Cedex 10, France
    Am J Respir Crit Care Med 176:814-8. 2007
    ..Thus, lung physicians should be aware that lung manifestations, presumably related to an immune-mediated mechanism rather than fluid retention, may occur with dasatinib treatment...
  28. ncbi Cytokine polarization in miliary and pleural tuberculosis
    Surendra K Sharma
    Department of Medicine, All India Institute of Medical Sciences, New Delhi, India
    J Clin Immunol 22:345-52. 2002
    Cytokines were measured in patients with pleural effusion and miliary tuberculosis (TB). Patients with pleural effusion had significantly higher interferon-gamma (IFN-gamma) levels (P < 0...
  29. ncbi Ultrasound-guided thoracentesis: is it a safer method?
    Phillip W Jones
    Saint Thomas Hospital, and Vanderbilt University, Nashville, TN 37205, USA
    Chest 123:418-23. 2003
    ....
  30. ncbi Parapneumonic effusions and empyema
    Richard W Light
    Division of Allergy, Critical Care, Pulmonary Disease, and Critical Care Medicine, Vanderbilt University, Nashville, Tennessee, USA
    Proc Am Thorac Soc 3:75-80. 2006
    ..The definitive procedure should be performed within 14 d...
  31. ncbi Identification of pneumococcal serotypes from culture-negative clinical specimens by novel real-time PCR
    D Tarrago
    Spanish Reference Laboratory for Pneumococci, Servicio de Bacteriologia, Centro Nacional de Microbiologia, Majadahonda, Madrid, Spain
    Clin Microbiol Infect 14:828-34. 2008
    ..Such molecular methods are critical for the diagnosis of invasive pneumococcal disease and continued epidemiological surveillance in order to monitor serotype vaccine effectiveness...
  32. ncbi Interleukin-8 production in tuberculous pleurisy: role of mesothelial cells stimulated by cytokine network involving tumour necrosis factor-alpha and interleukin-1 beta
    J S Park
    Department of Pulmonary Medicine, College of Medicine, Dankook University, Chonan, South Korea
    Scand J Immunol 57:463-9. 2003
    ..These findings demonstrate that both pleural macrophages and mesothelial cells produce IL-8 in tuberculous pleurisy, and cytokines produced by M. tuberculosis-infected macrophages mediate mesothelial cell IL-8 production...
  33. ncbi Multilevel likelihood ratios for identifying exudative pleural effusions(*)
    John E Heffner
    Medical University of South Carolina Drs Heffner and Sahn, Charleston, SC
    Chest 121:1916-20. 2002
    ..To determine multilevel likelihood ratios for pleural fluid tests that are commonly used to discriminate between exudative and transudative pleural effusions...
  34. ncbi Etiology of empyema thoracis and parapneumonic pleural effusion in Taiwanese children and adolescents younger than 18 years of age
    Tzou Yien Lin
    Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Taoyuan, Taiwan
    Pediatr Infect Dis J 32:419-21. 2013
    We analyzed blood and pleural fluid samples from 89 Taiwanese children with empyema thoracis and parapneumonic pleural effusion. Streptococcus pneumoniae was the major pathogen, identified in 12 children by bacterial culture and 53 ..
  35. ncbi [Diagnosis and treatment of pleural effusion]
    Victoria Villena Garrido
    Servicio de Neumología Hospital Universitario 12 de Octubre Madrid España
    Arch Bronconeumol 42:349-72. 2006
  36. ncbi Pleural fluid mesothelin for the differential diagnosis of exudative pleural effusions
    Carmen Alemán
    Department of Internal Medicine, Vall d Hebron University Hospital, Barcelona, Spain
    Med Clin (Barc) 133:449-53. 2009
    ..Recent studies have reported that determination of soluble mesothelin-related peptides (SMRP) in pleural fluid may be a promising marker for use in the diagnosis of MM...
  37. ncbi Pleural fluid characteristics of tuberculous pleural effusions
    Emmet E McGrath
    Department of Respiratory Medicine, Northern General Hospital, Sheffield, United Kingdom
    Heart Lung 39:540-3. 2010
    Mycobacterium tuberculosis (TB) infection of the pleural space is an important cause of pleural effusion in areas of high TB prevalence. Microbiological analyses of pleural fluid in the acute setting may be negative...
  38. ncbi Diagnostic approach to pleural effusion in adults
    Jose M Porcel
    Internal Medicine Department, Arnau de Vilanova University Hospital, Lleida, Spain
    Am Fam Physician 73:1211-20. 2006
    The first step in the evaluation of patients with pleural effusion is to determine whether the effusion is a transudate or an exudate. An exudative effusion is diagnosed if the patient meets Light's criteria...
  39. ncbi Monoclonal anti-vascular endothelial growth factor antibody reduces fluid volume in an experimental model of inflammatory pleural effusion
    Sabrina C C Ribeiro
    Laboratory of Pleura, Pulmonary Division, Heart Institute InCor, University of Sao Paulo Medical School, Sao Paulo, Brazil
    Respirology 14:1188-93. 2009
    ..This study describes the acute effects of VEGF blockade on the expression of inflammatory cytokines and pleural fluid accumulation...
  40. ncbi Pleural effusions
    Richard W Light
    Division of Allergy Pulmonary Critical Care, Vanderbilty University Medical Center, Nashville, TN 37232, USA
    Med Clin North Am 95:1055-70. 2011
    There are many diseases that cause pleural effusions. When a patient with a pleural effusion is first evaluated, one should determine if the patient has a transudate or an exudate...
  41. pmc Imbalance of Th17 cells and regulatory T cells in tuberculous pleural effusion
    Zhi Jian Ye
    Department of Respiratory Diseases, Key Laboratory of Pulmonary Diseases of Health Ministry, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
    Clin Vaccine Immunol 18:1608-15. 2011
    ..cells (Th17 cells) and regulatory T cells (Tregs) have been found to be increased in human tuberculous pleural effusion (TPE); however, the possible interaction between Th17 cells and Tregs in TPE remains to be elucidated...
  42. ncbi Role of pleural viscosity in the differential diagnosis of exudative pleural effusion
    Ozkan Yetkin
    Department of Chest Disease, Inonu University School of Medicine, Malayta, Turkey
    Respirology 12:267-71. 2007
    ..However, a reliable test for determining the aetiology of a pleural effusion is lacking...
  43. ncbi Useful tests on pleural fluid that distinguish transudates from exudates
    J M Porcel
    Department of Internal Medicine, University Hospital Arnau de Vilanova, Lleida, Spain
    Ann Clin Biochem 38:671-5. 2001
    ..This test combination avoids the need for venepuncture and the simultaneous collection of a blood sample...
  44. ncbi Comparison of six biological markers for the diagnosis of tuberculous pleuritis
    Akio Hiraki
    Department of Respiratory Medicine, National Sanyo Hospital, Respiratory Disease Center, Yamaguchi, Japan
    Chest 125:987-9. 2004
    ..We sought a marker to differentiate tuberculous pleural effusions from nontuberculous pleural effusions, which otherwise can be difficult...
  45. pmc Cell origins and diagnostic accuracy of interleukin 27 in pleural effusions
    Wei bing Yang
    Key Laboratory of Pulmonary Diseases of Health Ministry, Department of Respiratory and Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
    PLoS ONE 7:e40450. 2012
    ..The concentrations of IL-27 were determined in pleural fluids and sera from 68 patients with tuberculous pleural effusion, 63 malignant pleural effusion, 22 infectious pleural effusion, and 21 transudative pleural effusion...
  46. ncbi Differentiating transudative from exudative pleural effusion: should we measure effusion cholesterol dehydrogenase?
    Mathie P G Leers
    Department of Clinical Chemistry and Hematology, Atrium Medical Center Heerlen, Heerlen, The Netherlands
    Clin Chem Lab Med 45:1332-8. 2007
    ..In this study, the diagnostic properties of Light's criteria were compared to those of several other analytes for the classification of pleural fluids into transudative and exudative...
  47. ncbi Osteopontin is upregulated in malignant and inflammatory pleural effusions
    Charalampos Moschos
    Applied Biomedical Research and Training Center Marianthi Simou, Department of Critical Care and Pulmonary Services, General Hospital Evangelismos, School of Medicine, University of Athens, Athens
    Respirology 14:716-22. 2009
    ..In the present study, we asked whether pleural fluid (PF) and serum OPN concentrations differed between patients with pleural effusions of different aetiologies, and whether assessment of OPN levels was useful for diagnostic purposes...
  48. ncbi Pleurodesis is inhibited by anti-vascular endothelial growth factor antibody
    Yubiao B Guo
    Department of Respiratory and Critical Care Medicine, First Affiliated Hospital of Sun Yat sen University, Guangzhou, ROC
    Chest 128:1790-7. 2005
    ..This study investigated whether anti-vascular endothelial growth factor (VEGF) antibody has any effect on the fluid production or the pleurodesis induced by TGF-beta2...
  49. ncbi Clinical significance of pleural effusion mesothelin in malignant pleural mesothelioma
    Shusai Yamada
    Division of Respiratory Medicine, Department of Internal Medicine, Hyogo College of Medicine, Hyogo, Japan
    Clin Chem Lab Med 49:1721-6. 2011
    ..This study investigated the pleural effusion mesothelin levels in patients with MPM and compared them to those of a population with a non-malignant ..
  50. ncbi Serum mesothelin has a higher diagnostic utility than hyaluronic acid in malignant mesothelioma
    Bogdan Grigoriu
    INSERM Unit 774, Institut Pasteur de Lille, rue du Professeur Calmette, 59000 Lille, France
    Clin Biochem 42:1046-50. 2009
    ..We assessed comparatively the diagnostic value of two potential malignant pleural mesothelioma (MPM) markers: hyaluronic acid (HA) and soluble mesothelin...
  51. ncbi Diagnostic utility of pleural fluid IFN-gamma in tuberculosis pleural effusion
    S K Sharma
    Department of Medicine, All India Institute of Medical Sciences, New Delhi 110029, India
    J Interferon Cytokine Res 24:213-7. 2004
    Pleural fluid interferon-gamma (IFN-gamma) levels are increased in patients with tuberculosis (TB) pleural effusion. Recent studies from the west have found that estimation of pleural fluid IFN-gamma levels is an excellent diagnostic ..
  52. ncbi Diagnostic utility of interferon-gamma-induced protein of 10 kDa (IP-10) in tuberculous pleurisy
    Pokkali Supriya
    Department of Immunology, Tuberculosis Research Centre ICMR, Chennai 600 031, India
    Diagn Microbiol Infect Dis 62:186-92. 2008
    ..930). The better sensitivity (84.2% for IFN-gamma and 89.2% for IP-10) and equal specificity (95.7%) of IP-10 assay compared with IFN-gamma suggest that IP-10 is a potential diagnostic marker for evaluating TP...
  53. ncbi Clinical evaluation of HER-2/neu protein in malignant pleural effusion-associated lung adenocarcinoma and as a tumor marker in pleural effusion diagnosis
    Tsui Lien Hung
    Departments of Pathology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan 704, Taiwan
    Clin Cancer Res 9:2605-12. 2003
    Lung adenocarcinoma presenting as malignant pleural effusion (MPE) is common in Taiwan. Microscopically, the involved pleurae are infiltrated by numerous tumor foci, which suggests that the cancer cells are highly invasive...
  54. ncbi Outcomes of Category III DOTS treatment in immunocompetent patients with tuberculosis pleural effusion
    S K Sharma
    Department of Medicine, All India Institute of Medical Sciences, New Delhi, India
    Int J Tuberc Lung Dis 16:1505-9. 2012
    ..RMP], isoniazid [INH] and pyrazinamide for 2 months, followed by RMP and INH for 4 months) under India's Revised National Tuberculosis Control Programme in patients with uncomplicated small unilateral pleural effusion (<1500 ml).
  55. ncbi A prospective study of the volume of pleural fluid required for accurate diagnosis of malignant pleural effusion
    Wissam Abouzgheib
    Lung Center at Sparks Health System, Fort Smith, AR 72917 7006, USA
    Chest 135:999-1001. 2009
    ..This is a prospective study to define the volume of pleural fluid adequate for maximal yield of cytologic analysis of pleural fluid...
  56. pmc Immune response to Mycobacterium tuberculosis infection in the parietal pleura of patients with tuberculous pleurisy
    Gaetano Caramori
    Section of Respiratory Diseases, University of Ferrara, Ferrara, Italy
    PLoS ONE 6:e22637. 2011
    ..Elevated CD3, CD4, CCR4 and Th17 cells and decreased mast cells and GATA-3+ cells in the parietal pleura distinguish patients with untreated tuberculous pleurisy from those with nonspecific pleuritis...
  57. ncbi Diagnostic value of interleukin-12 p40 in tuberculous pleural effusions
    L Valdes
    Pulmonology Service, Complejo Hospitalario Clínico Universitario de Santiago, Santiago de Compostela, Spain
    Eur Respir J 33:816-20. 2009
    The diagnosis of tuberculous pleural effusion (TBPE) is frequently problematic. Several markers of TBPE in pleural fluid have been evaluated, with different results...
  58. ncbi Effector, memory and naïve CD8+ T cells in peripheral blood and pleural effusion from lung adenocarcinoma patients
    Heriberto Prado-Garcia
    Departamento de Enfermedades Cronico Degenerativas, Instituto Nacional de Enfermedades Respiratorias, Tlalpan 4502, Col Seccion XVI, CP 14080 Mexico City, Mexico
    Lung Cancer 47:361-71. 2005
    The proportions of naïve, memory and effector CD8+ T cells in peripheral blood and pleural effusion from lung adenocarcinoma patients were studied...
  59. ncbi A presumptive case of toxocariasis associated with eosinophilic pleural effusion: case report and literature review
    Mahi Lakshmi Ashwath
    Department of Internal Medicine, Section of Infectious Diseases, Mercer University School of Medicine, Macon, Georgia 31201, USA
    Am J Trop Med Hyg 71:764. 2004
    ..We report a case of eosinophilic pleural effusion and CD8 cell deficiency associated with Toxocara sp...
  60. ncbi Angiogenic molecule Tie-2 and VEGF in the pathogenesis of pleural effusions
    Foteini Economidou
    Department of Thoracic Medicine, University Hospital, Medical School, University of Crete, Heraklion 71110 Crete, Greece
    Respir Med 102:774-9. 2008
    The role of angiogenesis in the pathogenesis of pleural effusion (PE) has not been determined. The expression of angiogenic factors may represent useful markers for the diagnosis and prediction of disease outcome...
  61. ncbi Angiogenic factors and angiogenesis inhibitors in exudative pleural effusions
    Eva Ruiz
    Department of Internal Medicine, General Universitari Vall d Hebron, Barcelona, Spain
    Lung 183:185-95. 2005
    ..We analyzed pleural fluid from 105 patients with one of the following types of pleural effusion: empyema or complicated parapneumonic, non-complicated parapneumonic, tuberculous, neoplastic and ..
  62. ncbi Diagnostic accuracy, safety and utilisation of respiratory physician-delivered thoracic ultrasound
    Najib M Rahman
    Oxford Centre for Respiratory Medicine, Churchill Hospital, Oxford OX3 7LJ, UK
    Thorax 65:449-53. 2010
    ..pleural procedures are associated with fewer adverse events than 'blind' procedures for patients with pleural effusion. Ultrasound is increasingly practised by respiratory physicians but there has been no prospective assessment ..
  63. ncbi Pearls and myths in pleural fluid analysis
    Jose M Porcel
    Pleural Diseases Unit, Department of Internal Medicine, Arnau de Vilanova University Hospital, Institut de Recerca Biomedica de Lleida, Lleida, Spain
    Respirology 16:44-52. 2011
    Virtually all patients with a newly discovered pleural effusion should undergo thoracentesis to aid in diagnosis and management...
  64. ncbi Vascular endothelial growth factor and proinflammatory cytokines in pleural effusions
    Hiroaki Momi
    Third Department of Internal Medicine, Faculty of Medicine, Kagoshima University, Japan
    Respir Med 96:817-22. 2002
    ..VEGF) in the differential diagnosis of pleuritis and its association with other proinflammatory cytokines in pleural effusion, we measured VEGF together with interleukin-1beta (IL-1beta), tumor necrosis factor alpha (TNF-alpha) and ..
  65. ncbi Intrapleural fibrinolytic agents for empyema and complicated parapneumonic effusions: a meta-analysis
    Yasuharu Tokuda
    Department of Medicine, Okinawa Chubu Hospital, Okinawa, Japan
    Chest 129:783-90. 2006
    ..Randomized controlled trials have shown conflicting findings about the role of intrapleural fibrinolytic therapy for the treatment of empyema and complicated parapneumonic effusions in adult patients...
  66. ncbi Management of parapneumonic effusion and empyema: medical thoracoscopy and surgical approach
    Lukas Kern
    Division of Pulmonary and Sleep Medicine, Kantonsspital St Gallen, St Gallen, Switzerland
    Respiration 82:193-6. 2011
    ..Video-assisted thoracic surgery carries the advantage of providing optimal visibility of the pleural cavity, thus allowing better debridement. Thoracotomy is the treatment of choice when thoracoscopic cleaning is not satisfactory...
  67. ncbi Diagnostic value of tumor markers for differentiating malignant and benign pleural effusions of Iranian patients
    Sied Mohammad Ali Ghayumi
    Department of Internal Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
    Pathol Oncol Res 11:236-41. 2005
    ..neuron-specific enolase (NSE) and cancer antigen 125 (CA 125) were assayed prospectively in patients with pleural effusion (40 malignant and 37 benign)...
  68. ncbi Interferon-gamma release assays for the diagnosis of TB pleural effusions: hype or real hope?
    Clare E Hooper
    University of Bristol and North Bristol Lung Centre, Southmead Hospital, Bristol, UK
    Curr Opin Pulm Med 15:358-65. 2009
    ..However, questions remain regarding their clinical utility beyond conventional tests in the investigation of suspected active TB. We review the evidence base for IGRAs in the diagnosis or exclusion of pleural TB...
  69. ncbi Intrapleural alteplase in a patient with complicated pleural effusion
    Charlotte A Walker
    Chalmers P Wylie Veterans Affairs Outpatient Clinic, Columbus, OH, USA
    Ann Pharmacother 37:376-9. 2003
    To report the intrapleural use of alteplase in a patient diagnosed with complicated pleural effusion (CPE).
  70. ncbi Diagnostic utility of serum and pleural fluid carcinoembryonic antigen, neuron-specific enolase, and cytokeratin 19 fragments in patients with effusions from primary lung cancer
    Jin Hwa Lee
    Department of Internal Medicine, Ewha Womans University, Ewha Medical Research Institute, 911 1 MokDong, Yangcheon Ku, Seoul, South Korea
    Chest 128:2298-303. 2005
    ..To assess the diagnostic values of carcinoembryonic antigen (CEA), neuron-specific enolase (NSE), and cytokeratin 19 fragments (CYFRA 21-1) as markers of pleurisy in primary lung cancer...
  71. ncbi Diagnostic tests for tuberculous pleural effusion
    E E McGrath
    Department of Respiratory Medicine, Northern General Hospital, Sheffield S5 7AU, UK
    Eur J Clin Microbiol Infect Dis 29:1187-93. 2010
    The investigation of pleural effusion has been greatly assisted by advancements in pleural fluid analysis...
  72. ncbi Diagnostic tools in tuberculous pleurisy: a direct comparative study
    A H Diacon
    Institute of Internal Medicine, University of Stellenbosch Medical School, Tyberberg Hospital, Cape Town, South Africa
    Eur Respir J 22:589-91. 2003
    ....
  73. ncbi Differential diagnosis of tuberculous and malignant pleural effusions: what is the role of adenosine deaminase?
    Bojan Zaric
    Department for Interventional Pulmonology, Medical Faculty, Clinic for Pulmonary Oncology, Institute for Pulmonary Diseases of Vojvodina, University of Novi Sad, Institutski put 4, Sremska Kamenica 21204, Serbia
    Lung 186:233-40. 2008
    ..or biopsy specimen, tuberculous granulomas, or positive sputum cultures without other explanation for pleural effusion. Malignancy was diagnosed by either cytology or biopsy...
  74. ncbi Alternative widely available, inexpensive agents for pleurodesis
    Oner Dikensoy
    Department of Pulmonary Diseases, School of Medicine, Gaziantep University, Turkey
    Curr Opin Pulm Med 11:340-4. 2005
    Pleurodesis is the one of the best options for the management of symptomatic patients with malignant pleural effusion, recurrent benign pleural effusion, and recurrent pneumothorax...
  75. ncbi A randomized controlled trial of the efficacy of cosmetic talc compared with iodopovidone for chemical pleurodesis
    Ritesh Agarwal
    Department of Pulmonary Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, India
    Respirology 16:1064-9. 2011
    ..However, limited availability and high cost hamper the routine use of talc in resource poor countries. In this study, we compared the efficacy and safety of iodopovidone with that of cosmetic talc, for chemical pleurodesis...
  76. ncbi Diagnostic value of vascular endothelial growth factor and endostatin in malignant pleural effusions
    W B Zhou
    Department of Oncology, Hubei Provincial Corps Hospital, Chinese People Armed Police Forces, Wuhan, China
    Int J Tuberc Lung Dis 13:381-6. 2009
    ..To assess the value of vascular endothelial growth factor (VEGF) and endostatin in the differential diagnosis of malignant and tuberculous pleural effusions (PE)...
  77. ncbi Vascular endothelial growth factor correlates with matrix metalloproteinase-9 in the pleural effusion
    H Y Jin
    Department of Internal Medicine, Research Institute of Clinical Medicine, Chonbuk National University Medical School, 634 18, Keumamdong, Jeonju, 561 712, South Korea
    Respir Med 98:115-22. 2004
    ..Few data are available on the potential relationship between VEGF and MMP-9 in the accumulation of pleural effusion. We examined levels of VEGF and MMP-9 by means of enzyme immunoassay, zymographic analysis, and Western blot ..
  78. ncbi Biomarkers of infection for the differential diagnosis of pleural effusions
    J M Porcel
    Dept of Internal Medicine, Arnau de Vilanova University Hospital, Avda Alcalde Rovira Roure 80, 25198 Lleida, Spain
    Eur Respir J 34:1383-9. 2009
    ..Stored pleural fluid samples from 308 patients with different causes of pleural effusion were used to measure the four biomarkers...
  79. ncbi High level of vascular endothelial growth factor in hemorrhagic pleural effusion of cancer
    Osamu Ishimoto
    Department of Respiratory Oncology and Molecular Medicine, Institute of Development, Aging, and Cancer, Tohoku University, Sendai, Japan
    Oncology 63:70-5. 2002
    ..In contrast, neither bFGF nor angiogenin were correlated with any clinical manifestation of pleural effusion. Immunohistochemical study revealed that malignant cells in the pleura were stained with anti-VEGF antibody...
  80. ncbi Rheumatoid pleural effusion
    Alexandra Balbir-Gurman
    B Shine Department of Rheumatology, Rambam Medical Center, Haifa, Israel
    Semin Arthritis Rheum 35:368-78. 2006
    To describe the clinical and laboratory features of rheumatoid pleural effusion (RPE) and the diagnostic and therapeutic approaches to this condition.
  81. ncbi Genetic disruption of host nitric oxide synthase II gene impairs melanoma-induced angiogenesis and suppresses pleural effusion
    B Wang
    Department of Gastrointestinal Medical Oncology, University of Texas M.D. Anderson Cancer Center, Houston, TX, USA
    Int J Cancer 91:607-11. 2001
    ..Moreover, less metastatic pleural effusion was observed in NOS II(-/-) mice than in NOS II(+/+) mice...
  82. pmc Adenosine deaminase activity is a sensitive marker for the diagnosis of tuberculous pleuritis in patients with very low CD4 counts
    Kamaldeen Baba
    Institute of Medicine, University of Bergen, Bergen, Norway
    PLoS ONE 3:e2788. 2008
    Adenosine Deaminase Activity (ADA) is a commonly used marker for the diagnosis of tuberculous pleural effusion. There has been concern about its usefulness in immunocompromised patients, especially HIV positive patients with very low CD4 ..
  83. ncbi Clinically documented pleural effusions in medical ICU patients: how useful is routine thoracentesis?
    Muriel Fartoukh
    Medical and Respiratory Intensive Care Unit, Antoine Béclère Teaching Hospital, Paris, France
    Chest 121:178-84. 2002
    ..To assess the impact of routine thoracentesis on diagnostic assessment and therapeutic measures in patients with clinically documented pleural effusions...
  84. ncbi Soluble triggering receptor expressed on myeloid cells-1 for diagnosing empyema
    Jihad Bishara
    Infectious Diseases Unit, Tel Aviv University, Petah Tiqwa, Israel
    Ann Thorac Surg 87:251-4. 2009
    ..Our goal was to evaluate whether sTREM-1 in pleural fluid can distinguish pleural empyema from postthoracotomy-related pleural effusion and effusions of other etiologies.
  85. ncbi Paragonimiasis: a common cause of persistent pleural effusion in Lao PDR
    Sisoupanh Vidamaly
    Mahosot Hospital, Vientiane, Lao PDR
    Trans R Soc Trop Med Hyg 103:1019-23. 2009
    ..The disease should be considered in any case of elusive pleural effusion occurring in endemic areas.
  86. ncbi Circulating TNF-alpha, TGF-beta, and IL-10 in tuberculosis patients and healthy contacts
    J O Olobo
    Armauer Hansen Research Institute, PO Box 1005, Addis Ababa, Ethiopia
    Scand J Immunol 53:85-91. 2001
    ..Elevated TGF-beta in TB patients suggests its role in the immunopathogenesis...
  87. ncbi Polarized helper T cells in tubercular pleural effusion: phenotypic identity and selective recruitment
    Dipendra K Mitra
    Departments of Transplant Immunology and Immunogenetics, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, India
    Eur J Immunol 35:2367-75. 2005
    ..phenotype of Th1 cells and the role of chemotactic factors in their selective recruitment in tuberculosis pleural effusion and tuberculin site...
  88. ncbi Diagnosis and management of parapneumonic effusions and empyema
    Steve A Sahn
    Division of Pulmonary, Critical Care, Allergy, and Sleep Medicine, Medical University of South Carolina, Charleston, SC 29425, USA
    Clin Infect Dis 45:1480-6. 2007
    ..Fibrinolytics are most likely to be effective during the early fibrinolytic stage and may make surgical drainage unnecessary. If pleural space drainage is ineffective, video-assisted thoracic surgery should be performed without delay...
  89. ncbi Use of pleural fluid levels of adenosine deaminase and interferon gamma in the diagnosis of tuberculous pleuritis
    Rafał Krenke
    Department of Internal Medicine, Pneumonology and Allergology, Medical University of Warsaw, Warsaw, Poland
    Curr Opin Pulm Med 16:367-75. 2010
    ..the role of adenosine deaminase (ADA) and interferon gamma (IFN-gamma) in the differential diagnosis of pleural effusion with special attention to their source, mechanism of release and methods of measurement in pleural fluid...
  90. ncbi Matrix metalloproteinases in respiratory diseases: from pathogenesis to potential clinical implications
    Smaragda Oikonomidi
    Respiratory Medicine Department, University of Thessaly Medical School, University Hospital of Larissa, 41110 Larissa, Greece
    Curr Med Chem 16:1214-28. 2009
    ....
  91. ncbi Diagnostic significance of interferon-gamma in tuberculous pleural effusions
    Keisuke Aoe
    Department of Respiratory Medicine, National Sanyo Hospital, Respiratory Disease Center, Yamaguchi, Japan
    Chest 123:740-4. 2003
    Tuberculosis (TB), the single most frequent infectious cause of death worldwide, also is a major cause of pleural effusion, which in TB usually has lymphocytic and exudative characteristics...
  92. ncbi Immunocytochemical panel for distinguishing between carcinoma and reactive mesothelial cells in body cavity fluids
    Ekaterini Politi
    Department of Cytopathology, Aretaieio University Hospital, Athens, Greece
    Diagn Cytopathol 32:151-5. 2005
    ..Probably, calretinin is a more preferred marker for mesothelial cells as evidenced by a more intense staining reaction...
  93. ncbi On the identification of biomarkers for non-small cell lung cancer in serum and pleural effusion
    A M Rodríguez-Piñeiro
    Departamento de Bioquimica, Genética e Inmunología, Facultad de Biologia, Universidad de Vigo, Vigo, Spain
    J Proteomics 73:1511-22. 2010
    ..for new biomarkers of non-small cell lung cancer (NSCLC) prompted us to compare the proteome of serum and pleural effusion samples from cancer patients with those with benign lung diseases as pneumonia or tuberculosis...
  94. pmc Mycobacterium tuberculosis-induced gamma interferon production by natural killer cells requires cross talk with antigen-presenting cells involving Toll-like receptors 2 and 4 and the mannose receptor in tuberculous pleurisy
    Pablo Schierloh
    Departamento de Inmunologia, Instituto de Investigaciones Hematologicas, Academia Nacional de Medicina, Buenos Aires, Argentina
    Infect Immun 75:5325-37. 2007
    ..tuberculosis reaches its maximum value. Thus, interplay between M. tuberculosis and NK cells/APC triggering IFN-gamma would be expected to play a beneficial role in tuberculous pleurisy by helping to maintain a type 1 profile...
  95. ncbi Expression of CXC and CC type of chemokines and its receptors in tuberculous and non-tuberculous effusions
    Supriya Pokkali
    Department of Immunology, Tuberculosis Research Centre, Mayor V R Ramanathan Road, Chetpet, Chennai 600 031, India
    Cytokine 41:307-14. 2008
    ..Thus a selective concentration of chemokines, cytokines and abundant expression of chemokine receptors confirm the accumulation of activated and memory T cells at the site of infection and help in polarizing Th1 immune response...
  96. ncbi Causes of pleural exudates in a region with a high incidence of tuberculosis
    C K Liam
    Department of Medicine, University of Malaya Medical Centre, Kuala Lumpur, Malaysia
    Respirology 5:33-8. 2000
    ..To define the causes of exudative pleural effusions in our region...
  97. ncbi Incidence and aetiology of eosinophilic pleural effusion
    R Krenke
    Dept of Internal Medicine, Pneumonology and Allergology, Medical University of Warsaw, ul Banacha 1a, 02 097 Warsaw, Poland
    Eur Respir J 34:1111-7. 2009
    Although eosinophilic pleural effusion (EPE) has been a subject of numerous studies, its clinical significance still remains unclear...
  98. ncbi [A case of sparganosis with eosinophilic pleural effusion]
    Hiroyuki Kamiya
    Department of Respiratory Medicine, International Medical Center of Japan
    Nihon Kokyuki Gakkai Zasshi 42:1019-23. 2004
    A 61 year-old man was admitted to our hospital complaining of exertional dyspnea and presented with left pleural effusion. Laboratory findings showed peripheral eosinophilia and a slightly elevated inflammatory reaction...
  99. ncbi Parapneumonic pleural effusion and empyema
    Coenraad F N Koegelenberg
    Division of Pulmonology, Department of Medicine, University of Stellenbosch and Tygerberg Academic Hospital, Cape Town, South Africa
    Respiration 75:241-50. 2008
    At least 40% of all patients with pneumonia will have an associated pleural effusion, although a minority will require an intervention for a complicated parapneumonic effusion or empyema...
  100. ncbi CCL22 is involved in the recruitment of CD4+CD25 high T cells into tuberculous pleural effusions
    Cong Wu
    Institute of Respiratory Diseases, First Affiliated Hospital, Guangxi Medical University, Nanning, China
    Respirology 15:522-9. 2010
    ..The aim of this study was to investigate whether the chemokines CCL22 and CCL17 are present in TPE, and the chemoattractant activity of these chemokines for infiltration of CD4(+)CD25(high) T cells into the pleural space...
  101. ncbi Validity of procalcitonin and C-reactive protein measurement when differentiating between benign and malignant pleural effusion
    M Botana-Rial
    Unit of lnterventional Bronchopleural Pathology, Pneumology Department, Group of Investigation in Respiratory and Infectious Diseases GIERI, Spain
    Clin Lab 57:373-8. 2011
    ..CRP) measurements in pleural fluid and plasma have been proposed to facilitate differential diagnosis of pleural effusion (PE)...

Research Grants58

  1. TGF-BETA FOR PLEURODESIS
    Kirk Lane; Fiscal Year: 2005
    ..This condition is called malignant pleural effusion (MPE). This fluid impairs breathing and worsens the quality of life in these patients...
  2. Regulation of KSHV Latency
    Paul M Lieberman; Fiscal Year: 2013
    ..KSHV has also been implicated in several lymphoid disorders, including pleural effusion lymphoma (PEL) and Castleman's disease...
  3. Advancing a Lead Candidate Hantavirus Pulmonary Syndrome DNA Vaccine
    JAY WILLIAMS HOOPER; Fiscal Year: 2013
    ..in humans including: incubation time, rapid onset/progression, target tissue (endothelium), pulmonary edema, pleural effusion, and shock...
  4. Assay Development for Inhibitors of KSHV
    Paul M Lieberman; Fiscal Year: 2010
    ..KSHV has also been implicated in several lymphoid disorders, including pleural effusion lymphoma and Castlemen's disease...
  5. Conference Support for International Congress on Oncogenic Herpesviruses
    Paul M Lieberman; Fiscal Year: 2012
    ..population, and have complex cofactor roles in a variety of malignancies, including Kaposi's Sarcroma, pleural effusion lymphoma, and Multicentric Castleman's disease for KSHV, and Burkitt's lymphomas, nasopharyngeal ..
  6. KSHV genome modification in KS tissue
    Erle S Robertson; Fiscal Year: 2013
    ..In the HIV positive immunocompromised patients, pleural effusion lymphoma (PELs), Kaposi's sarcoma (KS) and Multicentric Castleman's Disease (MCD) are common...
  7. The Audible Human Project
    Thomas J Royston; Fiscal Year: 2013
    ..acoustic models capable of representing healthy and specific pathological conditions, including pneumothorax, pleural effusion, hydrothorax, mucous plugs, emphysema, obesity and masses (tumors) in the lung...
  8. Genome Persistence of KSHV
    Erle S Robertson; Fiscal Year: 2013
    ..These include Kaposi's sarcoma and body cavity based lymphomas (BCBLs) or Pleural Effusion Lymphomas (PELs)...
  9. Early Events in KSVH Infection of Primary B-cells
    Erle S Robertson; Fiscal Year: 2013
    ..is associated with a number of human cancers in particular AIDS associated Kaposi sarcoma (KS) and pleural effusion lymphomas (PELs)...
  10. KSHV vaccine development
    Jae U Jung; Fiscal Year: 2013
    ..sarcoma-associated herpesvirus (KSHV) has been consistently identified in Kaposi's sarcoma (KS) tumors, pleural effusion lymphomas, and multicentric Castleman's diseases...
  11. Peptide-mediated immunotherapy of KSHV-associated malignancy.
    Jae U Jung; Fiscal Year: 2010
    ..Kaposi's sarcoma-associated herpesvirus (KSHV) is an etiological agent to induce KS tumors, pleural effusion lymphomas and multicentric Castleman's disease...
  12. Mechanisms of Action of LANA encoded by KSHV
    Erle S Robertson; Fiscal Year: 2011
    ..associated with human malignancies including Kaposi's sarcoma and body cavity based lymphomas (BCBLs) or Pleural Effusion Lymphomas (PELs)...
  13. Training in Tumor Virology
    Erle S Robertson; Fiscal Year: 2013
    ..role in mediating these cancers as in the case of HIV related cancers which includes Kaposi's sarcoma, pleural effusion lymphomas and lymphoproliferative disease...
  14. Clinical Trial of DRibble Vaccine in NSCLC
    Walter Urba; Fiscal Year: 2009
    ..a pilot clinical trial of autologous DRibble vaccine in patients with stage IIIB or IV NSCLC with malignant pleural effusion or subcutaneous metastases as a source of autologous cancer cells for vaccine generation...
  15. TGF-BETA FOR PLEURODESIS
    Kirk Lane; Fiscal Year: 2000
    DESCRIPTION: (Adapted from the Investigator's Abstract) Pleural effusion is the accumulation of fluid between the chest wall and the lung. Malignant pleural effusion (MPE) occurs secondary to metastatic malignancy to the pleural surface...
  16. CRITICAL ROLE OF HHV8 ENCODED IRF IN AIDS LYMPHOMAS
    PAULA PITHA ROWE; Fiscal Year: 2001
    ..novel type of gamma herpes virus HHV-8/KSHV which was also found in a subset of AIDSimmunoblastic lymphomas, pleural effusion lymphomas (PEL). It is assumed that HHV-8 plays a role in the pathogenicity of these diseases...
  17. PLEURAL EFFUSION AND PULMONARY EDEMA FORMATION
    Steven Allen; Fiscal Year: 1991
    ..The amount of edema will be determined from the post mortem lung blood free wet and dry weights and the pleural effusion volume will be measured by aspirating the fluid from the pleural space...
  18. SQUALAMINE PLUS CARBOPLATIN AND PACLITAXEL IN NSC LUNG C
    Joan Schiller; Fiscal Year: 2000
    ..NSCLC, we are proposing a pilot and safety study of squalamine plus carbo/taxol in patients with Stage IIIB (pleural effusion only) and IV NSCLC...
  19. Capturing cancer cells with peptide bead technology
    Derick Lau; Fiscal Year: 2003
    ..is to develop a peptide-based technology to capture and expand cancer cells in body fluids, specifically pleural effusion. Pleural effusion is a common complication associated with malignancies especially lung cancer...
  20. QUANTIFICATION OF INTRATHORACIC FLUID BY IMPEDANCE
    Lee Baker; Fiscal Year: 1980
    ..the impedance technique for assessing respired volume, cardiac output, and intrathoracic fluid accumulation (pleural effusion, pericardial effusion, and pulmonary edema)...
  21. SCOR-PULMONARY VASCULAR DISEASES
    John Murray; Fiscal Year: 1993
    ..clinical and basic research projects concerned with two important clinical problems: pulmonary edema and pleural effusion. The objectives are to obtain new knowledge about the pathophysiology of liquid and protein exchange in the ..
  22. INNOVATIVE TUMOR TARGETED THERAPIES FOR LUNG CANCER
    Roman Perez Soler; Fiscal Year: 2004
    ..and 3) integration of intrapleural therapy in the treatment of patients with stage IIB NSCLC with malignant pleural effusion. All three projects include the performance of clinical trials that incorporate the measurement of ..
  23. Effect of diflunisal (IND68092) on familial amyloidosis
    JOHN BERK; Fiscal Year: 2009
    ..poiuytrewq c Diflunisal drug levels will be determined to assess treatment compliance. We will correlate FAP disease progression with TTR stabilization. ..
  24. CONTROL OF FIBRIN TURNOVER IN PLEURAL DISEASE
    Steven Idell; Fiscal Year: 2004
    ..This work could identify better, clinically feasible therapeutic approaches to prevent pleural fibrosis. ..
  25. DIETARY DEFICIENCIES AND TUBERCULOSIS VACCINE EFFICACY
    David McMurray; Fiscal Year: 2009
    ..abstract_text> ..
  26. NF KAPPA B MEDIATED CHEMORESISTANCE IN HUMAN LUNG CANCER
    David Jones; Fiscal Year: 2005
    ..The ultimate goal of this study is to provide the necessary background for the initiation of novel treatment strategies designed to treat patients with advanced lung cancer. ..
  27. TNF-Induced Apoptosis of Lymphocytes in Aged Humans
    Sudhir Gupta; Fiscal Year: 2004
    ..These studied should mechanism (s) for increased TNF-a-induced apoptosis during aging. ..
  28. MOUSE MODELS TO STUDY THE ROLE OF TRAF1 AND TRAF2 IN THE ETIOLOGY OF LEUKEMIA
    Juan Zapata; Fiscal Year: 2007
    ..Characterization of the CLL-like lymphoproliferative disorder caused by overexpression of TRAF2DN and Bcl-2 in B cells. [unreadable] [unreadable] [unreadable] [unreadable]..
  29. Computer-Aided Detection of Pulmonary Embolism on CT Pulmonary Angiography
    Chuan Zhou; Fiscal Year: 2007
    ..CAD will potentially reduce missed PEs and improve the chance of timely treatment of patients, thus reducing the mortality rate and speed up recovery from this condition. [unreadable] [unreadable]..
  30. Physiology of Systemic and Pulmonary Microangiectasias
    Steven Mentzer; Fiscal Year: 2006
    ..abstract_text> ..
  31. PLEURAL LIQUID EXCHANGE AND LUNG MECHANICS
    STEPHEN LAI FOOK; Fiscal Year: 2007
    ..A specific objective is to develop a method to separate passive from active transport properties of pericardium and diaphragm, tissues that have both mesothelium and interstitium. ..
  32. A randomized trial of influenza vaccination of Hutterite children
    Mark Loeb; Fiscal Year: 2006
    ..We believe that the trial we propose will lead to important data that can inform policy on influenza immunization strategy. [unreadable] [unreadable] [unreadable]..
  33. Artificial Nutrition in Terminally Ill Cancer Patients
    Sydney Dy; Fiscal Year: 2007
    ..Dy with the skills she needs to develop into an independent clinical researcher in oncology palliative care decision-making and health services research. ..
  34. IMMUNOSUPPRESSION IN MYCOBACTERIAL DISEASES
    Zahra Toossi; Fiscal Year: 2001
    ..3. To characterize the T-cell dysfunction of patients with active pulmonary tuberculosis, its relationship to TGF-beta and other suppressive cytokines (IL-10) and its reversal by inhibitors of TGF- beta. ..
  35. PEDIATRIC ONCOLOGY GROUP STUDIES
    Thomas McLean; Fiscal Year: 2002
    ....
  36. GENETIC CONTRIBUTION OF HOST AND PATHOGEN IN AFRICAN TB
    Leslie Louie; Fiscal Year: 2001
    ..They will evaluate host and mycobacterial genetic variation among 125 participants in each of four groups from each African study site: TB+/HIV+, TB+/HIV-, TB-/HIV+, TB-/HIV-. ..
  37. FDG PET-CT in Metastatic Prostate Cancer
    Hossein Jadvar; Fiscal Year: 2010
    ..Rigorous statistical methods will be applied to determine the diagnostic and prognostic performance of FDG PET-CT in this clinical setting. ..
  38. GENE SPECIFIC MUTATIONS IN SKIN INDUCED BY PEROXYNITRITE
    Fredika Robertson; Fiscal Year: 2001
    ..The hypothesis driving this research is that NO and peroxynitrite are mutagenic, and could be important contributors to oxidative DNA damage and mutation in human epidermal keratinocytes at sites of inflammation. ..
  39. Viral Infection and Primary Pulmonary Hypertension
    Blossom Damania; Fiscal Year: 2009
    ..Our hypothesis is that KSHV infection of endothelial cells predisposes the endothelial cells to aberrant signaling and proliferation, and this dysfunction is enhanced with HIV co infection. ..
  40. Cardiac MDCT for Early Triage of Patients with ACS
    Udo Hoffmann; Fiscal Year: 2008
    ..abstract_text> ..
  41. Flow Cytometry to Detect Human Tumor Cells in Body Fluid
    AWTAR GANJU KRISHAN; Fiscal Year: 2003
    ..3. Compare data collected from flow cytometric analysis with that obtained from cytopathology and immunocytochemistry routinely performed on these specimens for diagnostic purpose. ..
  42. Epidemiology of Marginal Zone Lymphoma
    Lisa Herrinton; Fiscal Year: 2003
    ..abstract_text> ..
  43. PULMONARY INTERSTITIAL MECHANICS
    STEPHEN LAI FOOK; Fiscal Year: 2004
    ..lungs. These studies will measure steric exclusion of albumin in interstitial cuffs of vessels ranging from arterioles to large vessels. ..
  44. UC4 AP4 Cancer Therapy Center
    Paul Bunn; Fiscal Year: 2004
    ..Chan, PI); 2) vaccine/ DNAI/ RNA therapy (R. Garcea, PI); 3) angiogenic inhibitors/ PK/ PD modeling (S.G. Eckhardt, PI); and 4) chemoprevention agents (R. Nemenoff, PI). ..
  45. Patterns of gene expression in Mulibrey Nanism
    Juan Zapata; Fiscal Year: 2005
    ..Specific Aim 2, is there any alteration in the patterns of gene expression induced by cytokines in normal and Mulibrey Nanism fibroblasts? Specific Aim 3, what is the role of TRIM37 in regulating gene expression? ..
  46. Chronic Lung Allograft Rejection in MHC-Defined Swine
    James Allan; Fiscal Year: 2005
    ..abstract_text> ..
  47. MOUSE MODELS TO STUDY MULIBREY NANISM
    Juan Zapata; Fiscal Year: 2005
    ..study the developmental and phenotypic alterations of trim37 knock out and FINmajor-mutated trim37 mice. These mice will be the foundation for further studies on the biology and etiology of Mulibrey Nanism. ..
  48. PATHOGENESIS OF SEVERE DENGUE INFECTIONS IN VENEZUELA
    Alan Rothman; Fiscal Year: 2004
    ..The results may also identify key pathophysiologic mechanisms that can be targeted for novel approaches to the treatment of adults with denaue infections. ..
  49. Clinical Trials of FTI Radiosensitization
    Stephen Hahn; Fiscal Year: 2005
    ..Specific molecular markers that are associated with activation of the Ras signaling pathway will be measured in NSCLC tumor biopsy specimens and will be related to the clinical efficacy of R115777 and radiotherapy. ..
  50. Symptom Management Intervention in Elderly CABG Patients
    Lani Zimmerman; Fiscal Year: 2006
    ..Also, a better understanding of HCU, patient satisfaction, and self-efficacy as variables will be described. ..
  51. Microangiectasia Regulation of Lymphocyte Migration
    Steven Mentzer; Fiscal Year: 2006
    ..abstract_text> ..
  52. Genetic system for thesus monkey rhadinovirus (RRV)
    Blossom Damania; Fiscal Year: 2005
    ..In addition, it would also help us shed light on the lifecycle and pathogenesis of the gamma herpesvirus family, in general. ..
  53. Transfer of the CD40 ligand gene to esophageal carcinoma
    Robert Korst; Fiscal Year: 2007
    ..This study will help determine if intratumoral administration of the AdCUCD40L vector is safe, and evokes sufficient DC-related host responses to warrant further studies in esophageal cancer. ..
  54. Mechanistic Studies at the Host-pathogen Interface
    David McMurray; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  55. Molecular Targets for Drug and Radiation Sensitivity
    Stephen Hahn; Fiscal Year: 2007
    ..abstract_text> ..
  56. Photodynamic Therapy for the Treatment of Obstructive E*
    Todd Demmy; Fiscal Year: 2007
    ..This proposal will be instrumental in the development of a novel PDT drug without long-term restrictions of patients' sun exposure. [unreadable] [unreadable]..
  57. Genetics of TB: Cytokine Response and Iron
    Leslie Louie; Fiscal Year: 2002
    ..To this end, we will recruit HIV+ and HIV- patients with PTB, HIV+ patients with EPTB (pleural effusion or lymphadenitis), or HIV+ and HIV- controls without TB who are PPD skin-test positive (n=125 per group, ..