nasal polyps

Summary

Summary: Focal accumulations of EDEMA fluid in the NASAL MUCOSA accompanied by HYPERPLASIA of the associated submucosal connective tissue. Polyps may be NEOPLASMS, foci of INFLAMMATION, degenerative lesions, or malformations.

Top Publications

  1. ncbi EPOS 2012: European position paper on rhinosinusitis and nasal polyps 2012. A summary for otorhinolaryngologists
    Wytske J Fokkens
    Department of Otorhinolaryngology, Academic Medical Center, Amsterdam, The Netherlands
    Rhinology 50:1-12. 2012
  2. ncbi Role of staphylococcal superantigens in upper airway disease
    Claus Bachert
    Upper Airway Research Laboratory, Ear Nose and Throat Department, University Hospital Ghent, Ghent, Belgium
    Curr Opin Allergy Clin Immunol 8:34-8. 2008
  3. ncbi Staphylococcus aureus invades the epithelium in nasal polyposis and induces IL-6 in nasal epithelial cells in vitro
    F Sachse
    Department of Otorhinolaryngology, University Hospital Munster, Munster, Germany
    Allergy 65:1430-7. 2010
  4. ncbi Differentiation of chronic sinus diseases by measurement of inflammatory mediators
    T Van Zele
    Upper Airway Research Laboratory URL, Department of Oto Rhino Laryngology, Ghent University Hospital, Ghent
    Allergy 61:1280-9. 2006
  5. ncbi Impact of topical nasal steroid therapy on symptoms of nasal polyposis: a meta-analysis
    Luke Rudmik
    Rhinology and Sinus Surgery, Division of Otolaryngology, Department of Surgery, University of Calgary, Calgary, Alberta, Canada
    Laryngoscope 122:1431-7. 2012
  6. ncbi Chronic rhinosinusitis: epidemiology and medical management
    Daniel L Hamilos
    Massachusetts General Hospital, Division of Rheumatology, Allergy and Immunology, Boston, MA 02114, USA
    J Allergy Clin Immunol 128:693-707; quiz 708-9. 2011
  7. ncbi Omalizumab is effective in allergic and nonallergic patients with nasal polyps and asthma
    Philippe Gevaert
    Upper Airways Research Laboratory, Department of Otorhinolaryngology, Ghent University Hospital, Ghent, Belgium
    J Allergy Clin Immunol 131:110-6.e1. 2013
  8. ncbi Expression of TGF, matrix metalloproteinases, and tissue inhibitors in Chinese chronic rhinosinusitis
    Xiaoyuan Li
    Department of Oto Rhino Laryngology, West China Medical School, Sichuan University, Chengdu, Sichuan, 610041, China
    J Allergy Clin Immunol 125:1061-8. 2010
  9. ncbi Presence of IL-5 protein and IgE antibodies to staphylococcal enterotoxins in nasal polyps is associated with comorbid asthma
    Claus Bachert
    Upper Airway Research Laboratory, Department of Oto Rhino Laryngology, Ghent University Hospital, Ghent, Belgium
    J Allergy Clin Immunol 126:962-8, 968.e1-6. 2010
  10. ncbi Infections after endoscopic polypectomy using nasal steroids
    Daniel Bross-Soriano
    Department of Otolaryngology, Manuel Gea Gonzalez General Hospital, Mexico City, Mexico
    Otolaryngol Head Neck Surg 130:319-22. 2004

Detail Information

Publications327 found, 100 shown here

  1. ncbi EPOS 2012: European position paper on rhinosinusitis and nasal polyps 2012. A summary for otorhinolaryngologists
    Wytske J Fokkens
    Department of Otorhinolaryngology, Academic Medical Center, Amsterdam, The Netherlands
    Rhinology 50:1-12. 2012
    The European Position Paper on Rhinosinusitis and Nasal Polyps 2012 is the update of similar evidence based position papers published in 2005 and 2007...
  2. ncbi Role of staphylococcal superantigens in upper airway disease
    Claus Bachert
    Upper Airway Research Laboratory, Ear Nose and Throat Department, University Hospital Ghent, Ghent, Belgium
    Curr Opin Allergy Clin Immunol 8:34-8. 2008
    Chronic rhinosinusitis with nasal polyps often represents a chronic severe inflammatory disease of the upper airways and may serve as a model for lower airway diseases such as late-onset intrinsic asthma...
  3. ncbi Staphylococcus aureus invades the epithelium in nasal polyposis and induces IL-6 in nasal epithelial cells in vitro
    F Sachse
    Department of Otorhinolaryngology, University Hospital Munster, Munster, Germany
    Allergy 65:1430-7. 2010
    Staphylococcus aureus has been associated with chronic rhinosinusitis with nasal polyps (CRSwNP) pathogenesis but its role is still controversially discussed. Here, we demonstrate S. aureus detection in the mucosa of CRSwNP...
  4. ncbi Differentiation of chronic sinus diseases by measurement of inflammatory mediators
    T Van Zele
    Upper Airway Research Laboratory URL, Department of Oto Rhino Laryngology, Ghent University Hospital, Ghent
    Allergy 61:1280-9. 2006
    ..Studying inflammatory cells and mediators in clearly defined disease subgroups may lead to a better differentiation of chronic sinus diseases...
  5. ncbi Impact of topical nasal steroid therapy on symptoms of nasal polyposis: a meta-analysis
    Luke Rudmik
    Rhinology and Sinus Surgery, Division of Otolaryngology, Department of Surgery, University of Calgary, Calgary, Alberta, Canada
    Laryngoscope 122:1431-7. 2012
    ..The objective of this study was to determine the impact of topical steroid therapy on nasal symptoms in patients with nasal polyposis...
  6. ncbi Chronic rhinosinusitis: epidemiology and medical management
    Daniel L Hamilos
    Massachusetts General Hospital, Division of Rheumatology, Allergy and Immunology, Boston, MA 02114, USA
    J Allergy Clin Immunol 128:693-707; quiz 708-9. 2011
    ..The various modalities of medical treatment are reviewed in the context of recent consensus documents and the author's personal experience...
  7. ncbi Omalizumab is effective in allergic and nonallergic patients with nasal polyps and asthma
    Philippe Gevaert
    Upper Airways Research Laboratory, Department of Otorhinolaryngology, Ghent University Hospital, Ghent, Belgium
    J Allergy Clin Immunol 131:110-6.e1. 2013
    Adult patients with nasal polyps often have comorbid asthma, adding to the serious effect on the quality of life of these patients...
  8. ncbi Expression of TGF, matrix metalloproteinases, and tissue inhibitors in Chinese chronic rhinosinusitis
    Xiaoyuan Li
    Department of Oto Rhino Laryngology, West China Medical School, Sichuan University, Chengdu, Sichuan, 610041, China
    J Allergy Clin Immunol 125:1061-8. 2010
    To date there is no information on the expression of mediators associated with tissue remodeling in Asian patients with chronic rhinitis with (CRSwNP) or without (CRSsNP) nasal polyps.
  9. ncbi Presence of IL-5 protein and IgE antibodies to staphylococcal enterotoxins in nasal polyps is associated with comorbid asthma
    Claus Bachert
    Upper Airway Research Laboratory, Department of Oto Rhino Laryngology, Ghent University Hospital, Ghent, Belgium
    J Allergy Clin Immunol 126:962-8, 968.e1-6. 2010
    b>Nasal polyps often are associated with asthma. The phenotype of these patients is unknown.
  10. ncbi Infections after endoscopic polypectomy using nasal steroids
    Daniel Bross-Soriano
    Department of Otolaryngology, Manuel Gea Gonzalez General Hospital, Mexico City, Mexico
    Otolaryngol Head Neck Surg 130:319-22. 2004
    ..An increase in infection has occurred with the use of fluticasone propionate after endoscopic polypectomy...
  11. ncbi Functional endoscopic sinus surgery improved asthma symptoms as well as PEFR and olfaction in patients with nasal polyposis
    A Ehnhage
    Department of Clinical Science, Intervention and Technology, Division of Otorhinolaryngology, Karolinska Institutet, Stockholm
    Allergy 64:762-9. 2009
    ..The management is anti-inflammatory, with topical and oral corticosteroids as the first-line treatment. The effect of surgical treatment on lower airway inflammation has not been sufficiently studied...
  12. ncbi Mucosal tissue polyclonal IgE is functional in response to allergen and SEB
    N Zhang
    Department of Oto Rhino Laryngology, Upper Airway Research Laboratory URL, Ghent University Hospital, Ghent, Belgium
    Allergy 66:141-8. 2011
    ..Staphylococcus aureus may modify airway disease by inducing local formation of polyclonal IgE antibodies (abs), the role of which is unknown...
  13. ncbi Histological and immunological features of non-eosinophilic nasal polyps
    Jeong Whun Kim
    Department of Otorhinolaryngology, Seoul National University College of Medicine, Seoul, Korea
    Otolaryngol Head Neck Surg 137:925-30. 2007
    The aim of this study was to investigate the histoimmunological features of non-eosinophilic nasal polyps (NPs).
  14. ncbi Sinonasal inhalation of dornase alfa in CF: A double-blind placebo-controlled cross-over pilot trial
    Jochen G Mainz
    Department of Paediatrics, Cystic Fibrosis Centre, University Hospital of Jena, Kochstrasse 2, 07740 Jena, Germany
    Auris Nasus Larynx 38:220-7. 2011
    The paranasal sinuses are almost always involved in cystic fibrosis, and chronic rhinosinusitis and nasal polyps are very frequent in the disease. Hereby, the patients' quality of life and their overall health are relevantly impaired...
  15. ncbi Why do we not find polyps in the lungs? Bronchial mucosa as a model in the treatment of polyposis
    Rogério Pezato
    Upper Airways Research Laboratory, Department of Otorhinolaryngology, Ghent University, Belgium
    Med Hypotheses 78:468-70. 2012
    ..there are no polyps with the features of nasal polyposis disease in the lower airway and through it is developed the hypothesis of the nasal polyps origin could partially lie on the difference between the upper and lower airway histology.
  16. pmc Eosinophil inflammation of nasal polyp tissue: relationships with matrix metalloproteinases, tissue inhibitor of metalloproteinase-1, and transforming growth factor-beta1
    Young Mok Lee
    Department of Allergy and Clinical Immunology, Ajou University School of Medicine, Suwon, Korea
    J Korean Med Sci 18:97-102. 2003
    ..Close correlations were noted between TGF-beta1, and MMP-9 and MMP-2, but not with TIMP-1. MMP-2, MMP-9, and TGF-beta1 may contribute to eosinophil and mast cell migrations into nasal polyp tissue...
  17. ncbi Alternatively activated macrophages and impaired phagocytosis of S. aureus in chronic rhinosinusitis
    O Krysko
    The Upper Airway Research Laboratory, Department of Oto Rhino Laryngology, Ghent University Hospital, Ghent, Belgium
    Allergy 66:396-403. 2011
    Chronic rhinosinusitis with nasal polyps (CRSwNP) is characterized by biased Th2 inflammation and CRS without nasal polyps (CRSsNP) by a Th1 immune response. Colonization by Staphylococcus aureus is increased in CRSwNP...
  18. pmc Differential expression of interleukin-32 in chronic rhinosinusitis with and without nasal polyps
    A Keswani
    Division of Allergy Immunology, Northwestern University Feinberg School of Medicine, 240 E Huron, Chicago, IL 60611, USA
    Allergy 67:25-32. 2012
    ..However, the mechanism of inflammation in CRS has still not been fully elucidated. The aim of the study was to investigate the role of interleukin-32 (IL-32), a recently discovered proinflammatory cytokine, in CRS...
  19. ncbi Treatment of recurrent chronic hyperplastic sinusitis with nasal polyposis
    Desiderio Passali
    ENT Department, University of Siena Medical School, Siena, Italy
    Arch Otolaryngol Head Neck Surg 129:656-9. 2003
    ....
  20. ncbi Quality of life is improved by endoscopic surgery and fluticasone in nasal polyposis with asthma
    P Olsson
    Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden
    Rhinology 48:325-30. 2010
    ..The aim was to investigate the health impact of nasal polyposis with asthma and to study effects of endoscopic sinus surgery (ESS), and addition of fluticasone propionate nasal drops (FPND), on health related quality of life (HRQoL)...
  21. pmc Evidence for distinct histologic profile of nasal polyps with and without eosinophilia
    Spencer C Payne
    Division of Rhinology and Sinus Surgery, Department of Otolaryngology Head and Neck Surgery, University of Virginia Health System, Charlottesville, Virginia 22908, USA
    Laryngoscope 121:2262-7. 2011
    To evaluate the histology, RNA, and protein signatures of nasal polyps (NPs) in order to demonstrate specific subtypes of disease and differentiate "idiopathic" NPs based on tissue eosinophilia.
  22. ncbi The expression of fibrinolytic components in chronic paranasal sinus disease
    Takayuki Sejima
    Upper Airway Research Laboratory, Department of Otorhinolaryngology, Ghent University Hospital, Ghent, Belgium
    Am J Rhinol Allergy 25:1-6. 2011
    ..To clarify the relationship between these components and the pathology of CRS, we analyzed fibrinolytic components in sinonasal mucosa of CRS...
  23. ncbi Prevalence of human papilloma virus and human herpes virus types 1-7 in human nasal polyposis
    Apostolos Zaravinos
    Laboratory of Virology, Medical School, University of Crete, Heraklion, Crete, Greece
    J Med Virol 81:1613-9. 2009
    ..VZV), Epstein-Barr virus (EBV), cytomegalovirus (CMV), and human herpes virus-6/-7 (HHV-6/-7) in 23 human nasal polyps by applying PCR...
  24. ncbi Staphylococcal exotoxins and nasal polyposis: analysis of systemic and local responses
    Anju Tripathi
    Division of Allergy Immunology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA
    Am J Rhinol 19:327-33. 2005
    ..The aim of this study was to correlate SAg activity as inferred by staphylococcal-specific T-cell receptor (TCR) V-beta expansion in the polyp and blood of CRS/NP patients with staphylococcal-specific anti-IgE antibodies in the serum...
  25. ncbi State of the art treatment of nasal polyposis
    Rony K Aouad
    Department of Otolaryngology Head and Neck Surgery, University of California, Davis School of Medicine, Sacramento, USA
    Am J Rhinol Allergy 25:291-8. 2011
    ..Nasal polyposis represents the end point of multiple inflammatory pathways and controversy continues as to the exact roles of medical and surgical approaches in the management of nasal polyposis...
  26. ncbi TGF-beta signaling and collagen deposition in chronic rhinosinusitis
    Nicholas Van Bruaene
    Upper Airway Research Laboratory, Department of Oto Rhino Laryngology, Ghent University Hospital, Ghent University, Ghent, Belgium
    J Allergy Clin Immunol 124:253-9, 259.e1-2. 2009
    ..Chronic rhinosinusitis is an inflammatory disease with distinct cytokine and remodeling patterns...
  27. ncbi Treatment of chronic rhinosinusitis with nasal polyposis with oral steroids followed by topical steroids: a randomized trial
    Sriram Vaidyanathan
    Ninewells Hospital, University of Dundee, United Kingdom
    Ann Intern Med 154:293-302. 2011
    ..Chronic rhinosinusitis (CRS) with nasal polyposis is common. The long-term efficacy and safety of approaches to medical management are not well-known...
  28. ncbi Reduced expression of COXs and production of prostaglandin E(2) in patients with nasal polyps with or without aspirin-intolerant asthma
    Jordi Roca-Ferrer
    Immunoallergia Respiratoria Clinica i Experimental, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, Barcelona, Spain
    J Allergy Clin Immunol 128:66-72.e1. 2011
    Researchers have debated whether regulation of the COX enzymes (COX-1 and COX-2), which mediate production of prostaglandins (PGs), affects the pathogenesis of nasal polyps (NPs) and aspirin-intolerant asthma (AIA).
  29. ncbi EP3OS 2007: European position paper on rhinosinusitis and nasal polyps 2007. A summary for otorhinolaryngologists
    Wytske Fokkens
    Department of Otorhinolaryngology, Amsterdam Medical Centre, The Netherlands
    Rhinology 45:97-101. 2007
  30. ncbi Fluticasone propionate aqueous nasal spray does not influence the recurrence rate of chronic rhinosinusitis and nasal polyps 1 year after functional endoscopic sinus surgery
    M D Dijkstra
    Department of Otorhinolaryngology, Erasmus MC, Rotterdam, The Netherlands
    Clin Exp Allergy 34:1395-400. 2004
    Local corticosteroids are widely used in the treatment of nasal polyps and chronic rhinosinusitis both before and after nasal surgery...
  31. ncbi Oral steroids and doxycycline: two different approaches to treat nasal polyps
    Thibaut Van Zele
    Department of Otorhinolaryngology, University Hospital Ghent, 9000 Ghent, Belgium
    J Allergy Clin Immunol 125:1069-1076.e4. 2010
    There is little scientific evidence to support the current practice of using oral glucocorticosteroids and antibiotics to treat patients with chronic rhinosinusitis and nasal polyps.
  32. ncbi Effective treatment of mild-to-moderate nasal polyposis with fluticasone delivered by a novel device
    Ingrid Vlckova
    Department of Otorinolaryngology, Palacky University, Olomouc, Czech Republic
    Rhinology 47:419-26. 2009
    ..To assess the efficacy and safety of fluticasone propionate administered using OptiNose's novel delivery device (Opt-FP) in subjects with bilateral mild-to-moderate nasal polyposis...
  33. ncbi Microarray cDNA to identify inflammatory genes in nasal polyposis
    Claudia R Figueiredo
    Department of Otorhinolaryngology, Head and Neck Surgery, Federal University of Sao Paulo, Brazil
    Am J Rhinol 21:231-5. 2007
    ..The objective of this study was to investigate the spectrum of inflammatory gene expression in patients with nasal polyposis...
  34. ncbi Microarray gene analysis of Toll-like receptor signaling elements in chronic rhinosinusitis with nasal polyps
    Chun yuan Zhao
    Department of Otorhinolaryngology and Head and Neck Surgery, Second Hospital Affiliated to Harbin Medical University, Harbin, China
    Int Arch Allergy Immunol 156:297-304. 2011
    To identify the regulatory mechanisms of Toll-like receptor (TLR)-associated genes in chronic rhinosinusitis (CRS) with nasal polyps (NP) using gene microarray analyses.
  35. ncbi Nasal IL-5 levels determine the response to anti-IL-5 treatment in patients with nasal polyps
    Philippe Gevaert
    Upper Airways Research Laboratory, Department of Otorhinolaryngology, Ghent University, Ghent, Belgium
    J Allergy Clin Immunol 118:1133-41. 2006
    Chronic rhinosinusitis with nasal polyps is characterized by an eosinophilic inflammation and high IL-5 levels.
  36. ncbi Distinct features of chronic rhinosinusitis with and without nasal polyps
    D Polzehl
    Department of Otorhinolaryngology Head and Neck Surgery, University of Ulm, Ulm, Germany
    Allergy 61:1275-9. 2006
    Based on the presence of nasal polyps on endoscopy, chronic rhinosinusitis (CRS) may be clinically divided in CRS with nasal polyps and CRS without nasal polyps...
  37. ncbi The association of oxidative stress and nasal polyposis
    E Cekin
    Department of Otolaryngology, Gulhane Military Medical Academy, Haydarpasa Training Hospital, Istanbul, Turkey
    J Int Med Res 37:325-30. 2009
    ..This study demonstrates that there is a strong relationship between oxidative stress and the pathogenesis of nasal polyposis...
  38. ncbi Inflammatory mechanisms and remodeling in chronic rhinosinusitis and nasal polyps
    Ruby Pawankar
    Department of Otolaryngology, Nippon Medical School, 1 1 5, Sendagi, Bunkyo ku, Tokyo 113 8603, Japan
    Curr Allergy Asthma Rep 7:202-8. 2007
    Chronic rhinosinusitis (CRS) is presently classified into two subgroups: CRS without and CRS with nasal polyps. A variety of inflammatory mediators, including cytokines and chemokines, as well as adhesion molecules and matrix ..
  39. ncbi Staphylococcus aureus colonization and IgE antibody formation to enterotoxins is increased in nasal polyposis
    Thibaut Van Zele
    J Allergy Clin Immunol 114:981-3. 2004
  40. ncbi Detection of Staphylococcus aureus in nasal tissue with peptide nucleic acid-fluorescence in situ hybridization
    Marie Noëlle Corriveau
    Upper Airways Research Laboratory URL, Department of Otorhinolaryngology, Ghent University Hospital, De Pintelaan 185, 9000 Ghent, Belgium
    Am J Rhinol Allergy 23:461-5. 2009
    ....
  41. ncbi Chronic sinusitis with nasal polyps: staphylococcal exotoxin immunoglobulin E and cellular inflammation
    David B Conley
    Department of Otolaryngology Head and Neck Surgery, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
    Am J Rhinol 18:273-8. 2004
    ..This study is designed to begin the assessment of the hypothesis that a similar mechanism takes place in CS/NP...
  42. ncbi The effect of macrolides on myofibroblast differentiation and collagen production in nasal polyp-derived fibroblasts
    Hyo Hyun Park
    Korea University College of Medicine, Seoul, Korea
    Am J Rhinol Allergy 24:348-53. 2010
    ....
  43. ncbi Topical steroids for nasal polyps
    Larry Kalish
    Sydney Sinus and Allergy Centre, Suite 206, 203 233 New South Head Road, Edgecliff, NSW, Australia, 2027
    Cochrane Database Syst Rev 12:CD006549. 2012
    Chronic rhinosinusitis with nasal polyps (CRSwNP) represents inflammatory changes throughout the nose and sinuses from a group of disorders which all lead to swelling and overgrowth of the nasal mucosa...
  44. ncbi Association of IL1A, IL1B, and TNF gene polymorphisms with chronic rhinosinusitis with and without nasal polyposis: A replication study
    Leandra Mfuna Endam
    Department of Otolaryngology, Centre de Recherche du Centre Hospitalier de l Université de Montréal Hôtel Dieu, Canada
    Arch Otolaryngol Head Neck Surg 136:187-92. 2010
    ....
  45. ncbi Nasal polyps in patients with and without cystic fibrosis: a differentiation by innate markers and inflammatory mediators
    S Claeys
    Upper Airways Research Laboratory, Department of Otorhinolaryngology, Ghent University, Belgium
    Clin Exp Allergy 35:467-72. 2005
    ..of the upper respiratory tract in cystic fibrosis (CF) patients is clinically visible by the development of nasal polyps (NP) at a young age...
  46. ncbi Prevention of relapses of nasal polyposis with intranasal triamcinolone acetonide after polyp surgery: a prospective double-blind, placebo-controlled, randomised study with a 9-month follow-up
    S I Vento
    Department of Otorhinolaryngology Head and Neck Surgery, Helsinki University, Central Hospital, Helsinki, Finland
    Clin Otolaryngol 37:117-23. 2012
    To determine whether intranasal triamcinolone acetonide prevents the regrowth of nasal polyps after polyp surgery.
  47. ncbi Mucin gene expression in nasal polyps
    Mahmoud S Ali
    Department of Otolaryngology and Head and Neck Surgery, University of Newcastle upon Tyne, Newcastle upon Tyne, UK
    Acta Otolaryngol 125:618-24. 2005
    A large set of mucin genes is expressed in nasal polyps. The expression pattern is complex and may reflect the wide spectrum of variables involved in polyp formation and progression...
  48. ncbi The Sino-Nasal Outcome Test (SNOT): can we make it more clinically meaningful?
    John Patrick Browne
    Clinical Effectiveness Unit, Royal College of Surgeons of England, London, UK
    Otolaryngol Head Neck Surg 136:736-41. 2007
    ..To test whether subscales should be used when analyzing the Sino-Nasal Outcome Test (SNOT)...
  49. pmc A global analysis of tandem 3'UTRs in eosinophilic chronic rhinosinusitis with nasal polyps
    Peng Tian
    Department of Otorhinolaryngology Head and Neck Surgery, Sun Yat Sen Memorial Hospital, Sun Yat Sen University, Guangzhou, PR China
    PLoS ONE 7:e48997. 2012
    ..Many disease processes reflect the importance of the regulation of APA site switching. The objective of this study was to explore the profiling of tandem APA sites in nasal polyps compared with nasal uncinate process mucosa.
  50. ncbi Oxidative stress induces unfolding protein response and inflammation in nasal polyposis
    L Jeanson
    INSERM, Creteil, France
    Allergy 67:403-12. 2012
    ..The main objective of this study was to investigate a potential involvement of the unfolded protein response (UPR) in the context of oxidative stress and inflammation in nasal epithelial cells from nasal polyps (NP).
  51. ncbi Clinical efficacy of a short course of systemic steroids in nasal polyposis
    Virat Kirtsreesakul
    Department of Otolaryngology, Faculty of Medicine, Prince of Songklu University, Thailand
    Rhinology 49:525-32. 2011
    ..The aim of this study was to evaluate the efficacy of a short course of oral prednisolone in nasal polyposis and to evaluate which, if any, clinical variables can predict treatment outcome in these patients...
  52. ncbi Sensitivity of a new grading system for studying nasal polyps with the potential to detect early changes in polyp size after treatment with a topical corticosteroid (budesonide)
    L Johansson
    Department of Otorhinolaryngology, Central Hospital, Skovde, Sweden
    Acta Otolaryngol 122:49-53. 2002
    We have previously compared different scoring systems for endoscopic staging of nasal polyps. Of the five methods evaluated, we found that two were better than the others with regard to reproducibility and agreement between physicians...
  53. ncbi Increased neutrophilia in nasal polyps reduces the response to oral corticosteroid therapy
    Weiping Wen
    Allergy and Cancer Center, Otorhinolarygology Hospital, First Affiliated Hospital of Sun Yat sen University, and the Otorhinolaryngology Institute of Sun Yat sen University, Guangzhou, China
    J Allergy Clin Immunol 129:1522-8.e5. 2012
    b>Nasal polyps (NPs) are characterized by eosinophilic inflammation, which is generally considered sensitive to corticosteroid treatment.
  54. ncbi HLA-DR and ICAM-1 expression and modulation in epithelial cells from nasal polyps
    Jean François Papon
    Institut National de la Sante et de la Recherche Medicale, Unité U492, Faculte de Medecine, Paris XII, Creteil, France
    Laryngoscope 112:2067-75. 2002
    ..epithelial cells could actively participate in the chronic inflammation and eosinophil infiltration observed in nasal polyps. The objective of the study was to evaluate HLA-DR and ICAM-1 expression in polyp epithelium and in a culture ..
  55. ncbi The pathogenesis of nasal polyposis by immunoglobulin E and interleukin-5 is completed by transforming growth factor-beta1
    Andor Hirschberg
    Department of Otorhinolaryngology Head and Neck Surgery, Faculty of Medicine, Semmelweis University, Budapest, Hungary
    Laryngoscope 113:120-4. 2003
    b>Nasal polyps are benign mucosal protrusions into the nasal cavity of multifactorial origin and are characterized by chronic mucosal inflammation...
  56. ncbi Local receptor revision and class switching to IgE in chronic rhinosinusitis with nasal polyps
    P Gevaert
    Upper Airways Research Laboratory, Department of Otorhinolaryngology, Ghent University, B 9000 Ghent, Belgium
    Allergy 68:55-63. 2013
    Chronic rhinosinusitis with nasal polyps (NP) and allergic rhinitis (AR) is characterized by local Th2 inflammation and up-regulation of IgE; however, IgE in NP is 'polyclonal' and allergen specific, whereas IgE in AR is 'oligoclonal' and ..
  57. ncbi Nasal polyps: still more questions than answers
    Neil D Bateman
    Department of Otorhinolaryngology, Royal Hallamshire Hospital, Sheffield, UK
    J Laryngol Otol 117:1-9. 2003
    b>Nasal polyps are common, affecting one to four per cent of the population. Their cause, however, remains unknown and it is possible that it is not the same in all patients...
  58. ncbi Effect of [6]-gingerol on myofibroblast differentiation in transforming growth factor beta 1-induced nasal polyp-derived fibroblasts
    Sook A Park
    Department of Otorhinolaryngology Head and Neck Surgery, Guro Hospital, Korea University College of Medicine, Seoul, South Korea
    Am J Rhinol Allergy 26:97-103. 2012
    ..the phenotypic transformation of fibroblasts to myofibroblasts, a process that is involved in the growth of nasal polyps by inducing extracellular matrix (ECM) accumulation...
  59. ncbi Increased expression of IL-19 in the epithelium of patients with chronic rhinosinusitis and nasal polyps
    E Pace
    Institute of Biomedicine and Molecular Immunology IBIM, National Research Council CNR, Palermo, Italy
    Allergy 67:878-86. 2012
    ..Chronic rhinosinusitis (CRS) is an inflammation of the nose and of the paranasal sinuses. The involvement of the respiratory epithelium in the mechanisms of CRS is poorly understood...
  60. ncbi Vitamin D3 deficiency increases sinus mucosa dendritic cells in pediatric chronic rhinosinusitis with nasal polyps
    Jennifer K Mulligan
    Research Service, Ralph H Johnson VA Medical Center, Charleston, South Carolina 29425, USA
    Otolaryngol Head Neck Surg 147:773-81. 2012
    ....
  61. ncbi Real-time PCR detection of Helicobacter pylori and virulence-associated cagA in nasal polyps and laryngeal disorders
    Mustafa Ozyurt
    Department of Microbiology and Clinical Microbiology, Gulhane Military Medical Academy, Haydarpasa Training Hospital, Istanbul, Turkey
    Otolaryngol Head Neck Surg 141:131-5. 2009
    To identify Helicobacter pylori and major virulence factor, cagA, in patients with laryngeal diseases and nasal polyps.
  62. ncbi Relationship between epithelial damage or basement membrane thickness and eosinophilic infiltration in nasal polyps with chronic rhinosinusitis
    Tatsuya Saitoh
    Department of Otorhinolaryngology, Juntendo University School of Medicine, Tokyo, Japan
    Rhinology 47:275-9. 2009
    Chronic rhinosinusitis (CRS) with nasal polyps is characterized by eosinophilic infiltration...
  63. ncbi Nasal polyps in cystic fibrosis: clinical endoscopic study with nasal lavage fluid analysis
    Gert Henriksson
    Department of Otolaryngology, Karolinska Institute, Huddinge University Hospital, Huddinge, Sweden
    Chest 121:40-7. 2002
    b>Nasal polyps frequently appear in patients with cystic fibrosis (CF)...
  64. ncbi Protein microarray analysis of nasal polyps from aspirin-sensitive and aspirin-tolerant patients with chronic rhinosinusitis
    Kelly A Zander
    Department of Otolaryngology Head and Neck Surgery, University of Colorado Denver, Denver, Colorado, USA
    Am J Rhinol Allergy 23:268-72. 2009
    ..microarray technology to the study of sinonasal tissue and to identify differential protein expression in nasal polyps from aspirin-sensitive (AS) versus aspirin-tolerant (AT) patients with chronic rhinosinusitis (CRS) and CRS ..
  65. ncbi Correlation between the prostaglandin D(2)/E(2) ratio in nasal polyps and the recalcitrant pathophysiology of chronic rhinosinusitis associated with bronchial asthma
    Tsuyoshi Yoshimura
    Department of Otorhinolaryngology, Jikei University School of Medicine, Tokyo, Japan
    Allergol Int 57:429-36. 2008
    ..We sought to assess the role of prostaglandin D(2) (PGD(2)) and prostaglandin E(2) (PGE(2)) in the recalcitrant pathophysiology of CRS...
  66. ncbi Role of interleukin-17A in the eosinophil accumulation and mucosal remodeling in chronic rhinosinusitis with nasal polyps associated with asthma
    T Saitoh
    Department of Otorhinolaryngology, Juntendo University School of Medicine, Bunkyo ku, Tokyo, Japan
    Int Arch Allergy Immunol 151:8-16. 2010
    ..The expression of IL-17A and its role were investigated in the nasal polyps of chronic rhinosinusitis associated with asthma.
  67. ncbi Biofilms in chronic rhinosinusitis with nasal polyps
    Thiago Freire Pinto Bezerra
    Department of Otorhinolaryngology and Ophthalmology, School of Medicine, University of Sao Paulo, Sao Paulo, SP, Brazil
    Otolaryngol Head Neck Surg 144:612-6. 2011
    1) Evaluate the presence of biofilms in patients with chronic sinusitis with nasal polyps (CRSwNP) and (2) investigate the association of biofilm presence and CRSwNP.
  68. ncbi Association of chronic rhinosinusitis with nasal polyps and asthma: clinical and radiological features, allergy and inflammation markers
    Jūrate Staikūniene
    Department of Pulmonology and Immunology, Kaunas University of Medicine, Eiveniu 2, 50009 Kaunas, Lithuania
    Medicina (Kaunas) 44:257-65. 2008
    Chronic rhinosinusitis (CRS) with and without nasal polyps represent different stages of one chronic inflammatory disease of the mucosa of the nasal cavity and paranasal sinuses...
  69. ncbi Polymorphisms in the tumour necrosis factor alpha-induced protein 3 (TNFAIP3) gene are associated with chronic rhinosinusitis
    Chantale Cormier
    Department of Otolaryngology, Hotel Dieu de Montreal, Montreal, QC, Canada
    J Otolaryngol Head Neck Surg 38:133-41. 2009
    ..Our objective was to determine whether polymorphisms in genes in the TNF superfamily (TNF, TNF-alpha-induced protein 3, TNF-alpha-induced protein 6) were associated with chronic rhinosinusitis...
  70. ncbi Amphotericin B irrigation for the treatment of chronic rhinosinusitis without nasal polyps: a randomized, placebo-controlled, double-blind study
    Kai Li Liang
    Department of Otolaryngology, Taichung Veterans General Hospital, Taichung, Taiwan
    Am J Rhinol 22:52-8. 2008
    ..Previous studies tested the efficacy of intranasal antifungal agents for patients with nasal polyps. The purpose of this study was to evaluate the efficacy of intranasal amphotericin B (AMB) in patients who have ..
  71. ncbi Group II subfamily secretory phospholipase A2 enzymes: expression in chronic rhinosinusitis with and without nasal polyps
    Z Liu
    Department of Otolaryngology Head and Neck Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
    Allergy 62:999-1006. 2007
    ..of this study was to investigate the expression of group II subfamily sPLA(2)s in human sinonasal mucosa from controls and CRS patients with and without nasal polyps (NPs) and the regulation of expression by proinflammatory cytokines.
  72. ncbi Efficacy and safety of mometasone furoate nasal spray in nasal polyposis
    Catherine Butkus Small
    Division of Infectious Diseases, New York Medical College, Valhalla, NY 10595, USA
    J Allergy Clin Immunol 116:1275-81. 2005
    Studies have suggested that topical corticosteroids are effective in the treatment of nasal polyps; however, this has yet to be confirmed in a large, robust clinical trial.
  73. ncbi Efficacy and tolerability of budesonide aqueous nasal spray treatment in patients with nasal polyps
    R Jankowski
    Department of Otorhinolaryngology, Head and Neck Surgery, Central Hospital, , F-54000 Nancy, France
    Arch Otolaryngol Head Neck Surg 127:447-52. 2001
    ..the efficacy and tolerability of once-daily treatment with budesonide aqueous nasal spray in patients with nasal polyps. DESIGN: Randomized, double-blind, placebo-controlled, parallel-group study. SETTING: Sixteen hospital clinics...
  74. ncbi Prevalence of nasal polyps in adults: the Skövde population-based study
    Leif Johansson
    Department of Otorhinolaryngology, Central Hospital, Skovde, Sweden
    Ann Otol Rhinol Laryngol 112:625-9. 2003
    Patients with nasal polyps present repeatedly in otorhinolaryngology practices, but the prevalence of nasal polyps in the general population is not known...
  75. ncbi Treatment of nasal polyposis and chronic rhinosinusitis with fluticasone propionate nasal drops reduces need for sinus surgery
    Albertien A C Aukema
    Department of Otorhinolaryngology, Erasmus University Medical Centre, Rotterdam, The Netherlands
    J Allergy Clin Immunol 115:1017-23. 2005
    Steroid treatment is the mainstay of therapy for nasal polyps and rhinosinusitis. Oral steroids have considerable systemic side effects, and nasal sprays do not sufficiently reach the middle meatus, where polyps originate...
  76. ncbi Distinct immunopathologic characteristics of various types of chronic rhinosinusitis in adult Chinese
    Ping Ping Cao
    Department of Otolaryngology Head and Neck Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
    J Allergy Clin Immunol 124:478-84, 484.e1-2. 2009
    Chronic rhinosinusitis (CRS) with nasal polyps (CRSwNP) and without nasal polyps (CRSsNP) is reported to be different in inflammatory patterns of the sinonasal mucosa in white patients...
  77. ncbi Different types of T-effector cells orchestrate mucosal inflammation in chronic sinus disease
    Nan Zhang
    Upper Airway Research Laboratory URL, Department of Oto Rhino Laryngology, Ghent University Hospital, Ghent, Belgium
    J Allergy Clin Immunol 122:961-8. 2008
    Chronic rhinosinusitis with nasal polyps (CRSwNP) is characterized by the accumulation of inflammatory cells; however, an eosinophil predominance is seen in white (Belgian), but not Asian (south Chinese), patients with polyps.
  78. ncbi T-cell regulation in chronic paranasal sinus disease
    Nicholas Van Bruaene
    Upper Airway Research Laboratory, Department of Otorhinolaryngology, Ghent University Hospital, Ghent, Belgium
    J Allergy Clin Immunol 121:1435-41, 1441.e1-3. 2008
    ..Chronic rhinosinusitis with nasal polyps (CRSwNP) is characterized by a T(H)2-skewed eosinophilic inflammation, whereas chronic rhinosinusitis without ..
  79. ncbi Gene profiling reveals increased expression of uteroglobin and other anti-inflammatory genes in glucocorticoid-treated nasal polyps
    Mikael Benson
    Laboratory for Clinical and Experimental Allergy Research, Department of Oto Rhino Laryngology, Malmo University Hospital, Malmo, Sweden
    J Allergy Clin Immunol 113:1137-43. 2004
    Treatment with local glucocorticoids (GCs) decreases symptoms and the size of nasal polyps. This might depend on the downregulation of proinflammatory genes, as well as the upregulation of anti-inflammatory genes.
  80. ncbi Genome-wide methylation profile of nasal polyps: relation to aspirin hypersensitivity in asthmatics
    H S Cheong
    Department of Genetic Epidemiology, SNP Genetics, Inc, Gasan Dong, Geumcheon gu, Seoul, Korea
    Allergy 66:637-44. 2011
    ..In addition to the dysregulation of arachidonic acid metabolism in aspirin-intolerant asthma (AIA), aspirin acetylsalicylic acid (ASA) exerts effects on inflammation and immunity; however, many of these effects are unknown...
  81. ncbi Gene-expression profiles in human nasal polyp tissues and identification of genetic susceptibility in aspirin-intolerant asthma
    T Sekigawa
    Department of Molecular Life Science, Tokai University School of Medicine, Isehara, Japan
    Clin Exp Allergy 39:972-81. 2009
    ..The lower airway lesion and the nasal polyp in AIA are postulated to have common pathogenic features involving aspirin sensitivity that would be reflected in the gene expression profile of AIA polyps...
  82. ncbi T cell inflammatory response, Foxp3 and TNFRS18-L regulation of peripheral blood mononuclear cells from patients with nasal polyps-asthma after staphylococcal superantigen stimulation
    C A Pérez Novo
    Upper Airways Research Laboratory, Department of Otorhinolaryngology, Ghent University Hospital, De Pintelaan 185, Ghent, Belgium
    Clin Exp Allergy 40:1323-32. 2010
    ..Staphylococcal superantigens may modulate airway inflammatory disease...
  83. ncbi Polymorphisms in the SERPINA1 (Alpha-1-Antitrypsin) gene are associated with severe chronic rhinosinusitis unresponsive to medical therapy
    Shaun J Kilty
    The Department of Otolaryngology, Hôpital Hôtel Dieu de Montréal, Universite de Montreal, Montreal, Quebec, Canada
    Am J Rhinol Allergy 24:e4-9. 2010
    ..This implies a potential genetic predisposition to CRS tied to AAT deficiency. The purpose of this study was to investigate the association between single nucleotide polymorphisms (SNPs) in the SERPINA1 gene and CRS...
  84. ncbi Nonasthmatic nasal polyposis patients with allergy exhibit greater epithelial MMP positivity
    Hyun Woo Shin
    Department of Otorhinolaryngology, Seoul National University College of Medicine, Seoul, Korea
    Otolaryngol Head Neck Surg 141:442-7. 2009
    ..To determine the influence of allergic rhinitis (AR) on the expression of matrix metalloproteinase (MMP)-9, MMP-2, and tissue inhibitor-1 of metalloproteinase (TIMP-1) in nasal polyposis...
  85. ncbi [Serum allergen-specific IgE in patients with eosinophilic nasal polyps]
    Ming Xu
    Department of Otorhinolaryngology, The Affiliated Hospital, Medical School of Ningbo University, Ningbo, 315020, China
    Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 26:772-3. 2012
    To investigate the relationship between airborne allergen and patients with nasal polyps (NP).
  86. pmc Microarray analysis of distinct gene transcription profiles in non-eosinophilic chronic sinusitis with nasal polyps
    Spencer C Payne
    Department of Otolaryngology Head and Neck Surgery, University of Virginia School of Medicine, Charlottesville, Virginia, USA
    Am J Rhinol 22:568-81. 2008
    ..inflammatory mechanisms would be involved in the pathophysiology of noneosinophilic chronic rhinosinusitis with nasal polyps (NE-CRSwNP) and that this technology could be used to identify the gene expression of these novel and ..
  87. ncbi Short-term antibiotics treatment in patients with nasal polyps and enterotoxins producing Staphylococcus aureus strains
    Petr Schalek
    Department of ENT FNKV, 3rd Medical Faculty of Charles University, Srobarova 50, 10034 Prague, Czech Republic
    Eur Arch Otorhinolaryngol 266:1909-13. 2009
    ..aureus (SA) can act as super-antigens and thus influence the course of chronic rhinosinusitis with nasal polyps (NP)...
  88. ncbi PCR analysis of nasal polyps, chronic sinusitis, and hypertrophied turbinates for DNA encoding bacterial 16S rRNA
    Gerald A Bucholtz
    Department of Allergy, Marshfield Clinic, Wisconsin 54449, USA
    Am J Rhinol 16:169-73. 2002
    b>Nasal polyps are considered to result from chronic inflammation, but the initial or persisting stimulus for the inflammation is not known...
  89. ncbi CFTR transgene expression in primary DeltaF508 epithelial cell cultures from human nasal polyps following gene transfer with cationic phosphonolipids
    Tristan Montier
    Universite de Bretagne Occidentale, Institute de Synergie des Sciences et de la Santé and 2UNR CNRS 6521, Faculte des Sciences, Brest, France
    Mol Biotechnol 26:193-206. 2004
    ..The transgene expression and the cytotoxicity correlate with the charge ratio of the lipoplex. A kinetic study was performed, and a luminescent signal was detected until 35 d after transfection...
  90. ncbi An angiomatous nasal polyp: a very rare variant of sinochoanal nasal polyps
    A Ceylan
    Department of Otorhinolaryngolgy, Gazi University School of Medicine, Ankara, Turkey
    B-ENT 3:145-7. 2007
    ..It was resected with both endonasal endoscopic and Caldwell-Luc approaches. Histopathological examination identified an angiomatous nasal polyp. Follow-up of thirteen months showed no recurrence...
  91. pmc Evidence for intranasal antinuclear autoantibodies in patients with chronic rhinosinusitis with nasal polyps
    Bruce K Tan
    Department of Otolaryngology Head and Neck Surgery, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    J Allergy Clin Immunol 128:1198-1206.e1. 2011
    Chronic rhinosinusitis (CRS) with nasal polyps is an inflammatory condition of the nasal passage and paranasal sinuses characterized by T(H)2-biased inflammation with increased levels of B-cell activating factor of the TNF family (BAFF), ..
  92. ncbi The new histologic classification of chronic rhinosinusitis
    Sonya Malekzadeh
    Department of Otolaryngology Head and Neck Surgery, Georgetown University, 1st Floor Gorman Building, 3800 Reservoir Road, NW, Washington, DC 20007 2197, USA
    Curr Allergy Asthma Rep 3:221-6. 2003
    ..This histologic classification should be acknowledged both in the clinical setting and in laboratory research of chronic rhinosinusitis...
  93. ncbi Alpha and beta glucocorticoid receptors: relevance in airway diseases
    Laura Pujols
    Servei d Otorinolaringologia, Hospital Clinic, Villarroel 170, 08036, Barcelona, Spain
    Curr Allergy Asthma Rep 7:93-9. 2007
    ..However, the role of GRbeta in modulating GC sensitivity in vivo has been highly debated and is as yet unclear...
  94. ncbi Do nasal polyps and inverted papilloma have similar disorders in cell cycle regulation?
    Simon Robinson
    Wakefield Hospital, Wellington, New Zealand
    Am J Rhinol 20:637-40. 2006
    The aim of this study was to determine the expression of cell cycle regulation genes in patients with inverted papilloma (IP) and compare this with expression in patients with nasal polyps (NPs).
  95. ncbi Interfacing medical and surgical management for chronic rhinosinusitis with and without nasal polyps
    Fuad M Baroody
    Section of Otolaryngology Head and Neck Surgery, Departments of Surgery and Pediatrics, Pritzker School of Medicine, University of Chicago, Chicago, Illinois, USA
    Clin Allergy Immunol 20:321-36. 2007
    ..The last section in this chapter provides guidance as to the combined medical and surgical management of various forms of CRS based on existing evidence from the literature...
  96. ncbi Polymorphisms in the nitric oxide synthase 1 gene are associated with severe chronic rhinosinusitis
    Yuan Zhang
    Department of Otolaryngology Head and Neck Surgery, Hotel Dieu de Montreal, Centre de recherche du Centre Hospitalier de l Universite de Montreal, QC, Canada
    Am J Rhinol Allergy 25:e49-54. 2011
    ..The purpose of this study was to determine whether polymorphisms in genes regulating NO synthesis are associated with CRS...
  97. ncbi [Effects of toll-like-receptor-9 expression in chronic rhinosinusitis with nasal polyps]
    Zhongfang Xia
    Department of Otolaryngology, Union Hospital Affiliated of Huazhong University of Science and Technology, Wuhan, 430022, China
    Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 22:631-3. 2008
    To determine the presence of TLR-9 protein in primary epithelial cell cultures of chronic rhinosinusitis with nasal polyps (CRSwNP), and then explore the role of innate immune recognition in the pathogenesis of CRSwNP.
  98. ncbi Significance of nasal polyps in chronic rhinosinusitis: symptoms and surgical outcomes
    R Tyson Deal
    Department of Otolaryngology Head and Neck Surgery, Medical College of Georgia, Augusta, GA 30912, USA
    Laryngoscope 114:1932-5. 2004
    To demonstrate the significance of nasal polyps on the symptoms of chronic rhinosinusitis (CRS) and their influence on surgical outcomes.
  99. ncbi Syk-kinase inhibition prevents mast cell activation in nasal polyps
    Joke Patou
    Upper Airways Research Laboratory, Department of Otorhinolaryngology, Ghent University, Ghent, Belgium
    Rhinology 49:100-6. 2011
    ..Spleen tyrosine kinase (Syk) is positioned upstream of the IgE receptor signal transducing pathway and may represent an important target for the treatment of nasal inflammatory diseases...
  100. ncbi Nasal contact endoscopy for the in vivo diagnosis of inverted schneiderian papilloma and unilateral inflammatory nasal polyps
    Fabrizio Ricci Romano
    Department of Otorhinolaryngology, University of Sao Paulo Medical School, Sao Paulo, SP, Brazil
    Am J Rhinol 21:137-44. 2007
    ..Any method that permits histopathological analysis without damage to the tissue studied deserves to be investigated. In this study, we tested a new noninvasive method, i.e., nasal contact endoscopy...
  101. ncbi Anti-IL-5 immunomodulates the effect of Staphylococcus aureus enterotoxin on T cell response in nasal polyps
    S Langier
    Allergy and Clinical Immunology Unit, Tel Aviv University, Tel Aviv, Israel
    Rhinology 49:570-6. 2011
    Chronic rhinosinusitis with nasal polyps (CRSwNP) is a T helper-2 (Th2) inflammatory disease with considerable impact on the quality of life. Staphylococcus aureus enterotoxins (SAEs) can induce and/or amplify inflammation...

Research Grants22

  1. 15-lipoxygenase regulation of mucosal immunity in allergic airways disease
    Douglas A Kuperman; Fiscal Year: 2011
    ..nasal tissue biopsies from subjects with the eosinophilic allergic airways disease, chronic rhinosinusitis with nasal polyps (CRSwNP). This is concerning because IgA binding to eosinophils induces their degranulation...
  2. Lipidomic and Transcriptome Signatures in Aspirin-Exacerbated Respiratory Disease
    Joshua A Boyce; Fiscal Year: 2010
    ..We will combine this with genome-wide analysis of the transcriptome of nasal polyps from the same individuals...
  3. Chronic Rhinosinusitis Integrative Studies Program (CRISP)
    Robert P Schleimer; Fiscal Year: 2013
    ..of CRS exacerbation and remission and the factors that explain variability;determine how CRS with and without nasal polyps cases differ from each other;evaluate a variety of community environmental risk factors for CRS using existing ..
  4. The inflammatory role of the platelet in aspirin-exacerbated respiratory disease.
    TANYA MARIA LAIDLAW; Fiscal Year: 2013
    ..AERD is characterized by asthma, recurrent nasal polyps, and respiratory reactions that occur upon ingestion of aspirin or other inhibitors of cyclooxygenase-1...
  5. Role of CC Chemokine Ligand 23 in Chronic Rhinosinusitis
    Atsushi Kato; Fiscal Year: 2013
    ..CRS is clinically classified into CRS with nasal polyps (CRSwNP) and CRS without nasal polyps (CRSsNP)...
  6. In vitro Models of Glandular Hyperplasia in Pediatric Chronic Rhinosinusitis
    Xiaofang Wu; Fiscal Year: 2013
    ..g. with and without nasal polyps. The fidelity of these models to in vivo sinus mucosa will be validated by immunohistochemistry using the sinus ..
  7. Role for B-cell mediated olfactory loss in Chronic Sinusitis with Nasal Polyps
    Bruce K Tan; Fiscal Year: 2013
    ..of B-cell mediated inflammation on the pathogenesis and olfactory loss associated with Chronic Sinusitis with Nasal Polyps (CRSwNP)...
  8. Olfactory-specific inflammation and disease severity in chronic rhinosinusitis
    Zachary M Soler; Fiscal Year: 2013
    ..CRS) is one of the most common causes of impaired olfaction, including subtypes with and without nasal polyps (CRSwNP and CRSsNP)...
  9. Pathophysiologic and therapeutic mechanisms of aspirin exacerbated respiratory d*
    Joshua A Boyce; Fiscal Year: 2013
    ..syndrome that accounts for a disproportionate percentage of individuals with severe asthma and recurrent nasal polyps. AERD is associated with both characteristic clinical reactions to ingestion of nonselective inhibitors of ..
  10. Planning a Multicenter Oral Itraconazole Trial in Chronic Rhinosinusitis Patients
    Hirohito Kita; Fiscal Year: 2007
    ..placebo-controlled clinical trial to investigate the efficacy of oral itraconazole in patients with CRS with nasal polyps. This novel study will propose that after a 6-week run-in period, CRS patients will be treated with oral ..
  11. GLUCOCORTICOSTEROID ACTION IN INFLAMMATORY DISEASE
    Robert Schleimer; Fiscal Year: 2009
    ..rhinosinusitis, a disease of the upper airways and sinuses that often is characterized by the formation of nasal polyps and blockade of the sinus openings and the upper airway passages...
  12. CF TS TRANSFORMANTS--BIOCHEMICAL AND GENETIC ANALYSIS
    Dieter Gruenert; Fiscal Year: 1992
    ..Clones of transformed CF epithelial cells will be derived from trachea, bronchi, submucosa, and nasal polyps. Transformants will initially be assayed for their epithelial origin, transformation- specific antigens, and ..
  13. TRANFORMED CYSTIC FIBROSIS CELLS--ASSAYS FOR THE GENE
    Manuel Buchwald; Fiscal Year: 1990
    ..Primary cultures derived from a total of 12 sweat glands and nasal polyps will be infected with an adeno- SV40 recombinant virus and the transformed cells isolated for further ..
  14. REGULATION OF NA & CL CHANNELS IN CYSTIC FIBROSIS CELLS
    Douglas Eaton; Fiscal Year: 1993
    ..The preparations which will be used are primary cultures derived from bronchial scrapings or nasal polyps and anepithelial call line ch expresses the CFTR protein (A6, originally derived from the distal nephron of ..
  15. IMMUNOPATHOGENESIS OF ALLERGIC ASPERGILLOSIS
    RAYMOND SLAVIN; Fiscal Year: 2003
    ..abstract_text> ..
  16. IMMUNOPATHOGENESIS OF ALLERGIC ASPERGILLOSIS
    RAYMOND SLAVIN; Fiscal Year: 2001
    ....
  17. INDIVIDUAL FACTORS IN NASAL IRRITANT SENSITIVITY
    Dennis Shusterman; Fiscal Year: 2002
    ....
  18. Cytokines on Olfactory Receptor Neuron Function
    Andrew Lane; Fiscal Year: 2006
    ..Additional bench research will be performed in the laboratory of Dr. Schleimer, an established scientist with expertise in airway inflammation and cytokine modulation of cell function. ..
  19. Global Gene Expression in Chronic Rhinosinusitis
    DOUGLAS PLAGER; Fiscal Year: 2005
    ..These new molecular approaches should shed light on the mechanisms of CRS and open novel avenues for diagnosis and treatment of this difficult disease. ..
  20. Nanostenting Hydrogels for Sinus Surgery
    RICHARD ORLANDI; Fiscal Year: 2004
    ..The results of these Phase I studies will determine the feasibility and the optimal chemical properties of a nanostenting HA gel for human trials. ..
  21. Proteomics of Cerebrospinal Fluid in Chronic Fatigue Syndrome
    James Baraniuk; Fiscal Year: 2009
    ..These methods and biomarkers may be of diagnostic value. They will be useful for assessing longitudinal changes in disease severity, phenotype, or the effects of treatment. ..