Genomes and Genes
Summary: A disease characterized by pulmonary infiltrations of eosinophils and blood eosinophilia.
Publications200 found, 100 shown here
- Contribution of IL-33-activated type II innate lymphoid cells to pulmonary eosinophilia in intestinal nematode-infected miceKoubun Yasuda
Department of Immunology and Medical Zoology, Hyogo College of Medicine, Nishinomiya 663 8501, Japan
Proc Natl Acad Sci U S A 109:3451-6. 2012..Finally, IL-33-stimulated NH cells induce lung eosinophilic inflammation and might aid to expel infected worms in the lungs...
- Interleukin-17 drives pulmonary eosinophilia following repeated exposure to Aspergillus fumigatus conidiaBenjamin J Murdock
Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, University of Michigan Medical School, Ann Arbor, Michigan, USA
Infect Immun 80:1424-36. 2012..These observations point to an expanded role for IL-17 in driving T(H)2-type inflammation to repeated inhalation of fungal conidia...
- Virus-specific CD8+ T lymphocytes downregulate T helper cell type 2 cytokine secretion and pulmonary eosinophilia during experimental murine respiratory syncytial virus infectionA Srikiatkhachorn
Beirne B Carter Center for Immunology Research, University of Virginia Health Sciences Center, Charlottesville 22908, USA
J Exp Med 186:421-32. 1997..to RSV-G (attachment) glycoprotein exhibit a strong interleukin (IL)-4 and IL-5 response and develop pulmonary eosinophilia, whereas mice sensitized to RSV-F (fusion) glycoprotein develop a predominantly T helper cell (Th)1 ..
- Marked airway eosinophilia prevents development of airway hyper-responsiveness during an allergic response in IL-5 transgenic miceTakao Kobayashi
Division of Allergic Diseases, Department of Internal Medicine, Mayo Clinic, Rochester, MN 55905, USA
J Immunol 170:5756-63. 2003..Overall, the roles of eosinophils in asthma and in animal models need to be addressed carefully for their potentially detrimental and beneficial effects...
- Eosinophilic lung diseases: diagnostic accuracy of thin-section CT in 111 patientsT Johkoh
Dept of Radiology, Osaka Univ Medical School, Suita, Japan
Radiology 216:773-80. 2000..To determine whether various eosinophilic lung diseases can be differentiated by means of thin-section computed tomography (CT)...
- A mouse model of airway disease: oncostatin M-induced pulmonary eosinophilia, goblet cell hyperplasia, and airway hyperresponsiveness are STAT6 dependent, and interstitial pulmonary fibrosis is STAT6 independentDominik K Fritz
Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada
J Immunol 186:1107-18. 2011..Thus, overexpression of mOSM induces STAT6-dependent pulmonary eosinophilia, mucous/goblet cell hyperplasia, and airway hyperresponsiveness but STAT6-independent mechanisms of lung ..
- IL-13 induces eosinophil recruitment into the lung by an IL-5- and eotaxin-dependent mechanismS M Pope
Division of Pulmonary Medicine, Allergy and Clinical Immunology, Department of Pediatrics, Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
J Allergy Clin Immunol 108:594-601. 2001..IL-13 induces several characteristic features of asthma, including airway eosinophilia, airway hyperresponsiveness, and mucus overproduction; however, the mechanisms involved are largely unknown...
- Acute eosinophilic pneumonia secondary to daptomycin: a report of three casesBecky A Miller
Division of Infectious Diseases, Duke University Medical Center, Durham, North Carolina, USA
Clin Infect Dis 50:e63-8. 2010..Clinical suspicion for this adverse drug event and cessation of daptomycin until definitive diagnosis can be made is crucial...
- Localized eosinophil degranulation mediates disease in tropical pulmonary eosinophiliaLaura O'Bryan
National Institutes of Health, Bethesda, Maryland, USA
Infect Immun 71:1337-42. 2003To explore the mechanisms underlying the eosinophil-mediated inflammation of tropical pulmonary eosinophilia (TPE), bronchoalveolar lavage (BAL) fluid, serum, and supernatants from pulmonary and blood leukocytes (WBC) from patients with ..
- Reciprocal immunomodulatory effects of gamma interferon and interleukin-4 on filaria-induced airway hyperresponsivenessR K Mehlotra
Division of Geographic, Department of Medicine, Case Western Reserve University, Cleveland, Ohio 44106, USA
Infect Immun 69:1463-8. 2001Tropical pulmonary eosinophilia (TPE) is a severe asthmatic syndrome of lymphatic filariasis, in which an allergic response is induced to microfilariae (Mf) in the lungs...
- Increased vascular endothelial growth factor in acute eosinophilic pneumoniaY Nishigaki
Dept of Respiratory Medicine, National Dohoku Hospital, Asahikawa, Japan
Eur Respir J 21:774-8. 2003....
- Tropical pulmonary eosinophilia: analysis of antifilarial antibody localized to the lungT B Nutman
Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892
J Infect Dis 160:1042-50. 1989Acute tropical pulmonary eosinophilia (TPE) is characterized by wheezing, pulmonary infiltrates, marked peripheral blood eosinophilia, and very high serum levels of filaria-specific antibodies...
- Pulmonary eosinophilia requires interleukin-5, eotaxin-1, and CD4+ T cells in mice immunized with respiratory syncytial virus G glycoproteinTeresa R Johnson
Vaccine Research Center, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, MD 20892 3017, USA
J Leukoc Biol 84:748-59. 2008Severe illness, type 2 cytokine production, and pulmonary eosinophilia are adverse immune responses resulting from respiratory syncytial virus (RSV) challenge of vvGs-immunized mice...
- FICZ, a tryptophan photoproduct, suppresses pulmonary eosinophilia and Th2-type cytokine production in a mouse model of ovalbumin-induced allergic asthmaKyu Tae Jeong
Department of Biology, Changwon National University, Changwon, Kyungnam 641 773, Korea
Int Immunopharmacol 13:377-85. 2012..FICZ significantly reduced pulmonary eosinophilia and Th2 cytokine expression in the lungs...
- Chlorogenic acid suppresses pulmonary eosinophilia, IgE production, and Th2-type cytokine production in an ovalbumin-induced allergic asthma: activation of STAT-6 and JNK is inhibited by chlorogenic acidHye Rin Kim
Department of Biology, Changwon National University, 9, Sarim dong, Changwon, Kyungnam 641 773, South Korea
Int Immunopharmacol 10:1242-8. 2010..CGA significantly reduced pulmonary eosinophilia and expression of IL-4, IL-5 and TNF-α in the lung as well as the serum levels of total and OVA-specific ..
- Idiopathic acute eosinophilic pneumonia: a study of 22 patientsFrancois Philit
Service d Assistance Respiratoire et Réanimation Médicale, Hopital de la Croix Rousse, Paris, France
Am J Respir Crit Care Med 166:1235-9. 2002..is characterized by acute febrile respiratory failure associated with diffuse radiographic infiltrates and pulmonary eosinophilia. We conducted a multicenter retrospective study to characterize this rare clinical entity further and to ..
- Suppression of asthma-like responses in different mouse strains by oral toleranceM Russo
Departamento de Imunologia, Instituto de Ciencias Biomedicas, Universidade de Sao Paulo, Sao Paulo, Brazil
Am J Respir Cell Mol Biol 24:518-26. 2001..Collectively, our findings show for the first time the beneficial and detrimental effects of oral Ag administration on the development of experimental asthma...
- Prostaglandin D2-induced eosinophilic airway inflammation is mediated by CRTH2 receptorYoshiki Shiraishi
Division of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
J Pharmacol Exp Ther 312:954-60. 2005..These results suggest that CRTH2 plays a significant role in the eosinophil trafficking from the bloodstream into the airways in PGD(2)-related airway inflammation...
- Inhibition of pulmonary eosinophilia in P-selectin- and ICAM-1-deficient miceD H Broide
Department of Medicine, University of California at San Diego, 92093 0635, USA
Am J Respir Cell Mol Biol 18:218-25. 1998..These studies suggest an important role for ICAM-1 and P-selectin in eosinophil recruitment to the lung after allergen challenge...
- Pulmonary eosinophiliaLuiz Eduardo Mendes Campos
Residency Program in Pulmonology and Respiratory Outpatient Clinic Júlia Kubitschek Hospital, Fundação Hospitalar do Estado de Minas Gerais FHEMIG, Hospital Foundation of the State of Minas Gerais Belo Horizonte, Brazil
J Bras Pneumol 35:561-73. 2009b>Pulmonary eosinophilia comprises a heterogeneous group of diseases defined by eosinophilia in pulmonary infiltrates (bronchoalveolar lavage fluid) or in tissue (lung biopsy specimens)...
- Effects of steroid therapy on inflammatory cell subtypes in asthmaDouglas C Cowan
Dunedin School of Medicine, University of Otago, P O Box 913, Dunedin, New Zealand
Thorax 65:384-90. 2010..ICS use led to phenotype misclassification. Steroid responsiveness was greater in EA, but the absence of eosinophilia did not indicate the absence of a steroid response. In NEA this was best predicted by baseline exhaled nitric oxide...
- The JAK-3 inhibitor CP-690550 is a potent anti-inflammatory agent in a murine model of pulmonary eosinophiliaElizabeth Kudlacz
Pfizer Global Research and Development, New London, CT 06320, USA
Eur J Pharmacol 582:154-61. 2008..The importance of IL-4 in the development of pulmonary eosinophilia was supported by a marked (90%) reduction in the influx of these cells in IL-4KO mice similarly sensitized ..
- IL-13 is required for eosinophil entry into the lung during respiratory syncytial virus vaccine-enhanced diseaseElaine M Castilow
Interdisciplinary Graduate Program in Immunology, University of Iowa, 51 Newton Road, Iowa City, IA 52242, USA
J Immunol 180:2376-84. 2008..Eosinophils are characteristic of Th2 responses, and Th2 cells are known to be necessary to induce pulmonary eosinophilia in RSV-infected BALB/c mice previously immunized with a recombinant vaccinia virus (vv) expressing the RSV ..
- Characterization of recombinant respiratory syncytial viruses with the region responsible for type 2 T-cell responses and pulmonary eosinophilia deleted from the attachment (G) proteinMatthew B Elliott
Department of Immunology, Wyeth Vaccines Research, 401 N Middletown Rd, Pearl River, NY 10965, USA
J Virol 78:8446-54. 2004..9-log(10)-unit reduction in RSV A2 levels 4 days after challenge. Importantly, pulmonary eosinophilia was significantly diminished in BALB/c mice primed with native G protein and challenged with either ..
- Chronic eosinophilic pneumonia: a case report and national surveyCatherine Wubbel
Department of Pediatrics, University of Florida College of Medicine, Gainesville 32610, USA
Chest 123:1763-6. 2003..The survey showed a low prevalence of acute eosinophilic pneumonia and CEP in the pediatric population, with an overall male/female ratio of 1.6:1...
- [Diagnosis of non-parasitic hypereosinophilia]Jean Emmanuel Kahn
Service de Medecine Interne, Hopital Foch, Suresnes
Presse Med 35:144-52. 2006..Corticosteroids are the first-line therapy. Mepolizumab, an anti-IL-5 monoclonal antibody, currently being evaluated, seems promising. Despite recent progress, about 40% of the cases of hypereosinophilic syndrome remain unexplained...
- Eosinophilic interstitial lung diseaseW Michael Alberts
H Lee Moffitt Cancer Center and the Department of Interdisciplinary Oncology, University of South Florida College of Medicine, Tampa, Florida 33612, USA
Curr Opin Pulm Med 10:419-24. 2004..This review and update will concentrate on the latter group of entities...
- Cyclosporin A increases the pulmonary eosinophilia induced by inhaled Aspergillus antigen in miceJ M Wang
Unite de Recherche, Centre de Pneumologie de l Hôpital Laval, Quebec, Canada
Clin Exp Immunol 93:323-30. 1993..fumigatus. The effect of CsA on this inflammatory response was paradoxical, insofar as it suggests an activation of the T helper 2 subset, which up-regulates eosinophil recruitment and IgE production...
- Establishment of airway eosinophilic bronchitis mouse model without hyperresponsiveness by ovalbuminLiyan Chen
State Key Laboratory of Respiratory Diseases, Guangzhou Medical College, 151 Yanjiang Road, 510120 GuangZhou, Guangdong, China
Clin Exp Med 11:19-24. 2011..A mouse model of EB without AHR can be established by 10 μg OVA challenge and provides a useful tool for studying AHR mechanisms...
- Clinical findings, bronchoalveolar lavage fluid cytology and matrix metalloproteinase-2 and -9 in canine pulmonary eosinophiliaMinna M Rajamäki
Department of Clinical Veterinary Sciences, Faculty of Veterinary Medicine, University of Helsinki, Finland
Vet J 163:168-81. 2002..features, and the involvement of gelatinolytic matrix metalloproteinases (MMP-2 and -9) in canine pulmonary eosinophilia (PE). Study material consisted of 20 PE dogs and 16 healthy beagles...
- Tropical pulmonary eosinophiliaJean Francois Magnaval
Clin Infect Dis 40:635-6. 2005
- Pulmonary eosinophilia is attenuated by early responding CD8(+) memory T cells in a murine model of RSV vaccine-enhanced diseaseWhitney W Stevens
Beirne B Carter Center for Immunology Research, University of Virginia, Charlottesville, Virginia 22908, USA
Viral Immunol 22:243-51. 2009..to mount an effective CD8(+) memory T-cell (CD8(+) Tm) response in this model could account for the pulmonary eosinophilia associated with the development of enhanced disease, and that CD8(+) T cells may control the development ..
- Enhanced disease and pulmonary eosinophilia associated with formalin-inactivated respiratory syncytial virus vaccination are linked to G glycoprotein CX3C-CX3CR1 interaction and expression of substance PLia M Haynes
Division of Viral and Rickettsial Diseases, National Center of Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
J Virol 77:9831-44. 2003..Enhanced pulmonary disease is characterized by pulmonary eosinophilia and is associated with a substantial inflammatory response...
- Airway allergen exposure stimulates bone marrow eosinophilia partly via IL-9Brigita Sitkauskiene
The Lung Pharmacology Group, Department of Respiratory Medicine and Allergology, Institute of Internal Medicine, Goteborg University, Guldhedsgatan 10A, 413 46 Gothenburg, Sweden
Respir Res 6:33. 2005..We aimed to evaluate the therapeutic effect of a neutralizing anti-IL-9 antibody in a mouse model of airway eosinophilic inflammation and compared any such effect with anti-IL-5 treatment...
- Idiopathic chronic eosinophilic pneumonia and asthma: how do they influence each other?E Marchand
Centre d Etudes et de Recherche sur les Maladies Orphelines Pulmonaires, Hopital Cardiovasculaire et Pneumologique Louis Pradel, Universite Claude Bernard, Hospices Civils de Lyon, France
Eur Respir J 22:8-13. 2003..The occurrence of idiopathic chronic eosinophilic pneumonia in asthmatics is often associated with the development of severe asthma...
- Understanding respiratory syncytial virus (RSV) vaccine-enhanced diseaseElaine M Castilow
Interdisciplinary Graduate Program in Immunology, University of Iowa, 3 532 Bowen Science Building, 51 Newton Road, Iowa City, IA 52242, USA
Immunol Res 39:225-39. 2007..previously immunized with a formalin-inactivated (FI)-RSV vaccine is associated with enhanced disease and pulmonary eosinophilia that is believed to be due to an exaggerated memory Th2 response...
- Transient pulmonary eosinophilia incidentally found on low-dose computed tomography: findings in 40 individualsHyae Young Kim
Department of Radiology, Center for Lung Cancer, Research Institute and Hospital, National Cancer Center, Gyeonggi Do, Korea
J Comput Assist Tomogr 32:101-7. 2008To describe computed tomography (CT) findings of transient pulmonary eosinophilia (TPE) incidentally found on low-dose CT (LDCT) and to identify suggestive CT features helpful in initial diagnosis.
- Localisation and distribution of Wuchereria bancrofti antigens recognised by antisera from tropical pulmonary eosinophilia and from individuals with intestinal helminthsC A Peixoto
Department of Cellular Pathology and Biology, Research Center Aggeu Magalhães, Recife, Brazil
J Submicrosc Cytol Pathol 35:61-8. 2003Serological analyses of sera from patients with a typical picture of filarial tropical pulmonary eosinophilia (TPE) and sera from patients from a region non-endemic for filariasis harbouring intestinal helminths, as Ascaris lumbricoides ..
- Tachykinin NK3-receptor deficiency does not inhibit pulmonary eosinophilia in allergic miceT T Kung
Department of Allergy and Immunology, Schering Plough Research Institute, 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA
Pharmacol Res 50:611-5. 2004..These results find no role for tachykinin NK3-receptors on the pulmonary eosinophilia and lung damage after antigen challenge in mice.
- Parasitic pulmonary eosinophiliaRajinder K Chitkara
Division of Pulmonary and Critical Care Medicine, Veterans Affairs Palo Alto Healthcare System, Stanford University School of Medicine, Palo Alto, California 94304, USA
Semin Respir Crit Care Med 27:171-84. 2006..b>Pulmonary eosinophilia occurs in almost all metazoan infections...
- A rho kinase inhibitor, Y-27632 inhibits pulmonary eosinophilia, bronchoconstriction and airways hyperresponsiveness in allergic micePeter J Henry
Pharmacology Unit, School of Medicine and Pharmacology, University of Western Australia, Perth 6009, Australia
Pulm Pharmacol Ther 18:67-74. 2005..These inhibitory effects of intranasal Y-27632 on pulmonary eosinophilia were accompanied by a significant inhibition of the development of airways hyperresponsiveness in allergic ..
- Multiple antigen challenge produces pulmonary eosinophilia but not pulmonary hyperresponsiveness in actively sensitized guinea pigsJ W Watson
Department of Immunology and Infectious Diseases, Pfizer Inc, Groton, CT 06340
Agents Actions 37:174-7. 1992..of actively sensitized boosted guinea pigs to aerosolized antigen, 3 times on alternate days, produced pulmonary eosinophilia but not pulmonary hyperresponsiveness to methacholine Cl measured 3 days after the last antigen challenge...
- Subcellular site of expression and route of vaccination influence pulmonary eosinophilia following respiratory syncytial virus challenge in BALB/c mice sensitized to the attachment G proteinG P Bembridge
Institute for Animal Health, Newbury, Berkshire, United Kingdom
J Immunol 161:2473-80. 1998..The induction of pulmonary eosinophilia in rVV-primed mice was also dependent upon the route of vaccination...
- Circulating, but not local lung, IL-5 is required for the development of antigen-induced airways eosinophiliaJ Wang
Immunology and Infection Program, Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada L8N 3Z5
J Clin Invest 102:1132-41. 1998..These findings also provide the rationale for developing strategies to target circulating IL-5 and/or its receptors in bone marrow to effectively control asthmatic airways eosinophilia...
- Pulmonary eosinophiliaUriel Katz
Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
Clin Rev Allergy Immunol 34:367-71. 2008..Migratory peripheral infiltrates are seen in the chest x-ray film. Both acute and chronic eosinophilic pneumonia are treated by glucocorticoids and respiratory support as well as avoidance of any recognized trigger...
- Interstitial lung disease induced by drugs and radiationPhilippe Camus
Department of Pulmonary and Intensive Care, University Medical Center Le Bocage and Medical School, Universite de Bourgogne, Dijon, France
Respiration 71:301-26. 2004..Rechallenge is justified in a minority of patients, and is discouraged for diagnostic purposes only. Pneumotox (www.pneumotox.com) provides updated information on drug-induced respiratory disease...
- A role for CD44 in an antigen-induced murine model of pulmonary eosinophiliaShigeki Katoh
Third Department of Internal Medicine, Miyazaki Medical College, Miyazaki, Japan
J Clin Invest 111:1563-70. 2003..We have used experimental pulmonary eosinophilia induced in mice by Ascaris suum (Asc) extract to investigate the role of CD44 in the development of ..
- CD4+CD25+ T cells regulate airway eosinophilic inflammation by modulating the Th2 cell phenotypeZeina Jaffar
Center for Environmental Health Sciences, University of Montana, Missoula, MT 59812, USA
J Immunol 172:3842-9. 2004..Conceivably, this is partly a consequence of regulatory T cells facilitating the production of IL-10...
- C57BL/6 mice are more susceptible to antigen-induced pulmonary eosinophilia than BALB/c mice, irrespective of systemic T helper 1/T helper 2 responsesT Morokata
Inflammation Research Pharmacology Laboratories, Institute for Drug Discovery Research, Yamanouchi Pharmaceutical Co Ltd, Ibaraki, Japan
Immunology 98:345-51. 1999..Therefore, local immune responses are more important in the induction of allergic inflammation in the lungs and are different from systemic immune responses, which are thought to depend on genetic background...
- Eosinophilic pneumoniasV Cottin
Department of Pulmonary Medicine, and Center for Orphan Lung Diseases, Louis Pradel University Hospital, Claude Bernard University, UMR 754 INRA ENVL UCBL and IFR128 Biosciences, Lyon, France
Allergy 60:841-57. 2005..The adjunction of immunosuppressants to corticosteroids is necessary in patients with CSS and poor prognosis factors. Imatinib has recently proven effective in the treatment of the myeloproliferative variant of the HES...
- Respiratory syncytial virus infection of gene gun vaccinated mice induces Th2-driven pulmonary eosinophilia even in the absence of sensitisation to the fusion (F) or attachment (G) proteinG P Bembridge
Institute for Animal Health, Compton, Newbury, RG20 7NN, Berkshire, UK
Vaccine 19:1038-46. 2000..In contrast, the BAL from mice vaccinated with control plasmid contained significantly more eosinophils than any other group...
- Tropical pulmonary eosinophilia: pathogenesis, diagnosis and managementVannan Kandi Vijayan
Vallabhbhai Patel Chest Institute, University of Delhi, India
Curr Opin Pulm Med 13:428-33. 2007Tropical pulmonary eosinophilia is predominantly seen in the tropical and subtropical regions of the world. It is being increasingly reported from other parts of world, however, due to increases in global travel and migration...
- Drug-, toxin-, and radiation therapy-induced eosinophilic pneumoniaJoshua Solomon
Department of Pulmonary Sciences and Critical Care Medicine, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
Semin Respir Crit Care Med 27:192-7. 2006..Radiation therapy has also been associated with the development of eosinophilic pneumonia in patients receiving this treatment for breast cancer...
- An essential role for interleukin-5 and eosinophils in helminth-induced airway hyperresponsivenessL R Hall
Divisions of Geographic, Department of Medicine, Case Western Reserve University, Cleveland, Ohio 44106, USA
Infect Immun 66:4425-30. 1998..parasitic helminth Brugia malayi can result in development of a severe asthmatic response termed tropical pulmonary eosinophilia. This disease, thought to result from a host inflammatory response to blood parasites which become trapped ..
- Hierarchical suppression of asthma-like responses by mucosal toleranceAlexandre C Keller
Department of Immunology, Biomedical Science Institute, University of Sao Paulo, Brazil
J Allergy Clin Immunol 117:283-90. 2006..Mucosal tolerance can be induced by oral or nasal administration of soluble proteins and results in the suppression of cellular and/or humoral immune responses to the specific antigen...
- Sputum eosinophilia and short-term response to prednisolone in chronic obstructive pulmonary disease: a randomised controlled trialC E Brightling
Institute for Lung Health, Department of Respiratory Medicine, Glenfield Hospital, Leicester, UK
Lancet 356:1480-5. 2000..Whether these patients have different airway pathology from other COPD patients is unclear. We tested the hypothesis that response to prednisolone is related to the presence of eosinophilic airway inflammation...
- Differential role of gamma interferon in inhibiting pulmonary eosinophilia and exacerbating systemic disease in fusion protein-immunized mice undergoing challenge infection with respiratory syncytial virusElaine M Castilow
Interdisciplinary Graduate Program in Immunology, University of Iowa, Iowa City, IA 52242, USA
J Virol 82:2196-207. 2008..BALB/c mice with a recombinant vaccinia virus (vv) expressing the attachment (G) protein of RSV results in pulmonary eosinophilia upon RSV challenge, whereas immunization of mice with a vv expressing the fusion (F) protein does not...
- Immune responses to the nonglycosylated ectodomain of respiratory syncytial virus attachment glycoprotein mediate pulmonary eosinophilia in inbred strains of mice with different MHC haplotypesGerald E Hancock
Department of Immunology Research, Wyeth Vaccines, West Henrietta, New York 14586 9728, USA
J Med Virol 70:301-8. 2003..As demonstrated by IL-5-dependent pulmonary eosinophilia after challenge and serum anti-G protein IgG1 to IgG2 ratios, highly purified native G protein sensitized ..
- The eotaxin chemokines and CCR3 are fundamental regulators of allergen-induced pulmonary eosinophiliaSamuel M Pope
Division of Allergy and Immunology, Department of Pediatrics, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
J Immunol 175:5341-50. 2005..These results imply that successful blockade of Ag-induced pulmonary eosinophilia will require antagonism of multiple CCR3 ligands.
- Mannitol challenge for assessment of airway responsiveness, airway inflammation and inflammatory phenotype in asthmaL G Wood
Respiratory and Sleep Medicine, Hunter Medical Research Institute, John Hunter Hospital, New Lambton, NSW, Australia
Clin Exp Allergy 40:232-41. 2010..Assessment of airway inflammation in asthma is becoming increasingly important, as the inflammatory phenotype underpins the treatment response...
- Tropical pulmonary eosinophiliaE A Ottesen
Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892
Annu Rev Med 43:417-24. 1992Tropical pulmonary eosinophilia is one of the many PIE syndromes [pulmonary infiltrates with eosinophilia (of the peripheral blood)]...
- Exhaled nitric oxide measurements: clinical application and interpretationD R Taylor
Department of Medical and Surgical Sciences, Dunedin School of Medicine, University of Otago, P O Box 913, Dunedin, New Zealand
Thorax 61:817-27. 2006..However, a number of issues still need to be resolved, including the diagnostic role of F(E)NO in preschool children and the use of reference values versus individual F(E)NO profiles in managing patients with difficult or severe asthma...
- Genetic polymorphisms of eosinophil-derived neurotoxin and eosinophil cationic protein in tropical pulmonary eosinophiliaYae Jean Kim
Laboratory of Malaria and Vector Research, Biostatistics Research Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
Am J Trop Med Hyg 73:125-30. 2005..neurotoxin (EDN) and eosinophil cationic protein (ECP) are critical in the pathogenesis of tropical pulmonary eosinophilia (TPE), we analyzed genetic polymorphisms of both in 181 individuals from southern India with varying ..
- Simple pulmonary eosinophilia evaluated by means of FDG PET: the findings of 14 casesTae Jung Kim
Department of Radiology, Seoul National University Bundang Hospital, Gyeonggi Do, Korea
Korean J Radiol 6:208-13. 2005We wanted to describe the findings of simple pulmonary eosinophilia with using 18 fluorodeoxyglucose (FDG) positron emission tomography (PET).
- A New York City firefighter: overwhelmed by World Trade Center dustWilliam S Beckett
Am J Respir Crit Care Med 166:785-6. 2002
- Elevated interleukin-18 levels in bronchoalveolar lavage fluid of patients with eosinophilic pneumoniaS Katoh
Third Department of Internal Medicine, Miyazaki Medical College, 5200 Kihara, Kiyotake, Miyazaki 889 1692, Japan
Allergy 59:850-6. 2004..To evaluate the role of IL-18 in the pathogenesis of EP, we measured the concentration of IL-2, IL-12, IL-18, and Th2 cytokines in BALF from patients with EP...
- Mouse model of airway remodeling: strain differencesKazuhiko Shinagawa
Pharmacology Lab, Kissei Pharmaceutical Co Ltd, Minamiazumi, Nagano, Japan
Am J Respir Crit Care Med 168:959-67. 2003..In particular, useful qualitative and quantitative information relating to the structural and histologic changes in the lungs may be obtainable using this model...
- Oral tolerance inhibits pulmonary eosinophilia in a cockroach allergen induced model of asthma: a randomized laboratory studyLouis J Vaickus
Boston University School of Medicine, Department of Pathology and Laboratory Medicine, Boston, MA, USA
Respir Res 11:160. 2010..In this study we endeavored to induce oral tolerance to cockroach allergen (CRA: a complex mixture of insect components) in order to ameliorate asthma-like, allergic pulmonary inflammation...
- Chronic cough: eosinophilic bronchitis without asthmaP G Gibson
Department of Medicine, McMaster University, Hamilton, Ontario, Canada
Lancet 1:1346-8. 1989..Airway inflammation with eosinophils and metachromatic cells is not always accompanied by increased airway responsiveness, and current definitions of obstructive airways disease may need to be revised...
- C5 modulates airway hyperreactivity and pulmonary eosinophilia during enhanced respiratory syncytial virus disease by decreasing C3a receptor expressionGuillermina A Melendi
INFANT Fundacion, Buenos Aires, Argentina
J Virol 81:991-9. 2007..was characterized by immune complex-mediated airway hyperreactivity and a severe pneumonia associated with pulmonary eosinophilia. In this paper, we show that complement factors contribute to enhanced-disease phenotypes...
- Acute fibrinous and organizing pneumonia: a histological pattern of lung injury and possible variant of diffuse alveolar damageMary Beth Beasley
Department of Pulmonary, Armed Forces Institute of Pathology, Washington, DC 20306, USA
Arch Pathol Lab Med 126:1064-70. 2002....
- Elevated immunoglobulin E against recombinant Brugia malayi gamma-glutamyl transpeptidase in patients with bancroftian filariasis: association with tropical pulmonary eosinophilia or putative immunityEdgar Lobos
The Wolfson Institute for Biomedical Research, University College London, United Kingdom
Infect Immun 71:747-53. 2003..malayi, a homologue of gamma-glutamyl transpeptidase (gamma-GT), is involved in the pathology of tropical pulmonary eosinophilia (TPE) through its potent allergenicity and the induction of antibodies against the host pulmonary ..
- Suppression of allergen reactive Th2 mediated responses and pulmonary eosinophilia by intranasal administration of an immunodominant peptide is linked to IL-10 productionGillian Hall
Respiratory Medicine Unit, Immunobiology Group, Rayne Laboratory, MRC Centre for Inflammation Research, University of Edinburgh Medical School, Teviot Place, Edinburgh EH8 9AG, UK
Vaccine 21:549-61. 2003..The mucosal administration of a peptide containing an immunodominant region of an allergen can protect against the induction of systemic and local inflammatory responses to allergen challenge...
- Acute eosinophilic pneumonia following cigarette smoking: a case report including cigarette-smoking challenge testKazuyoshi Watanabe
Department of Internal Medicine, Sinminato Municipal of Hospital, Sinminato
Intern Med 41:1016-20. 2002..After the challenge, eosinophilic pneumonia was documented by BALF and TBLB findings, which were similar to those detected on admission, without significant radiographic findings...
- Antisense therapy against CCR3 and the common beta chain attenuates allergen-induced eosinophilic responsesGail M Gauvreau
Department of Medicine, McMaster University, Hamilton, Ontario, Canada
Am J Respir Crit Care Med 177:952-8. 2008....
- Acute eosinophilic pneumonia among US Military personnel deployed in or near IraqAndrew F Shorr
Pulmonary, Critical Care, and Sleep Medicine Service, Walter Reed Army Medical Center, Washington, DC 20307, USA
JAMA 292:2997-3005. 2004..Acute eosinophilic pneumonia (AEP) is a rare disease of unknown etiology characterized by respiratory failure, radiographic infiltrates, and eosinophilic infiltration of the lung...
- OX40 ligation on activated T cells enhances the control of Cryptococcus neoformans and reduces pulmonary eosinophiliaIan R Humphreys
Center for Molecular Microbiology and Infection, Department of Biochemistry, Imperial College of Science, Technology and Medicine, London, United Kingdom
J Immunol 170:6125-32. 2003b>Pulmonary eosinophilia induced in C57BL/6 mice after Cryptococcus neoformans infection is driven by CD4(+) Th2 cells. The immunological mechanisms that protect against eosinophilia are not fully understood...
- A critical role for Pin1 in allergic pulmonary eosinophilia in ratsStephane Esnault
Waisman Center for Developmental Disabilities, Department of Pathology and Laboratory Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI 53705, USA
J Allergy Clin Immunol 120:1082-8. 2007..We recently showed that in vitro Pin1 regulated eosinophil production of and response to GM-CSF...
- Eosinophilic lung diseases: a clinical, radiologic, and pathologic overviewYeon Joo Jeong
Department of Diagnostic Radiology, Pusan National University Hospital, Pusan National University School of Medicine and Medical Research Institute, 1 10, Ami dong, Seo Gu, Pusan 602 739, Korea
Radiographics 27:617-37; discussion 637-9. 2007..They are classified as eosinophilic lung diseases of unknown cause (simple pulmonary eosinophilia [SPE], acute eosinophilic pneumonia [AEP], chronic eosinophilic pneumonia [CEP], idiopathic ..
- Chronic eosinophilic pneumonia after radiation therapy for breast cancerV Cottin
Service de Pneumologie, Hopital Cardiovasculaire et Pneumologique Louis Pradel, Universite Claude Bernard, Lyon, France
Eur Respir J 23:9-13. 2004....
- Acute eosinophilic pneumoniaJames Allen
Department of Clinical Internal Medicine, Division of Pulmonary and Critical Care Medicine, Ohio State University, Columbus, Ohio 43205, USA
Semin Respir Crit Care Med 27:142-7. 2006..In some patients, acute eosinophilic pneumonia may be caused by drugs, tobacco smoke, or other inhaled substances; however, in the majority of patients, the condition is idiopathic...
- In vivo IL-10 gene delivery suppresses airway eosinophilia and hyperreactivity by down-regulating APC functions and migration without impairing the antigen-specific systemic immune response in a mouse model of allergic airway inflammationKazuyuki Nakagome
Department of Allergy and Rheumatology, Graduate School of Medicine, University of Tokyo, Japan
J Immunol 174:6955-66. 2005..Therefore, if delivered selectively, IL-10 could site specifically suppress the Ag-specific immune response without affecting systemic immune responses...
- Antigen-induced airway hyperresponsiveness, pulmonary eosinophilia, and chemokine expression in B cell-deficient miceJ A MacLean
Clinical Immunology and Allergy Unit and Infectious Disease Unit, Department of Medicine, Massachusetts General Hospital, Boston 02114, USA
Am J Respir Cell Mol Biol 20:379-87. 1999..pulmonary inflammation share many features with human asthma, including the development of antigen-induced pulmonary eosinophilia, airway hyperresponsiveness, antigen-specific cellular and antibody responses, the elaboration of Th2 ..
- Priming with a secreted form of the fusion protein of respiratory syncytial virus (RSV) promotes interleukin-4 (IL-4) and IL-5 production but not pulmonary eosinophilia following RSV challengeG P Bembridge
Institute for Animal Health, Compton, Newbury RG20 7NN, United Kingdom
J Virol 73:10086-94. 1999..However, this change alone does not appear sufficient to induce vaccine-augmented disease in the face of active CD8(+) CTL populations...
- Gq signaling is required for allergen-induced pulmonary eosinophiliaMichael T Borchers
Division of Pulmonary Medicine, Mayo Clinic, Scottsdale AZ 85259, USA
J Immunol 168:3543-9. 2002..leukocytes in the lung elicits expression of GM-CSF, which, in turn, is required for allergen-induced pulmonary eosinophilia, identifying a novel pathway of eosinophil-associated effector functions leading to pulmonary pathology in ..
- Innate and cognate mechanisms of pulmonary eosinophilia in helminth infectionFiona J Culley
Leukocyte Biology Section, Biomedical Sciences Division, Imperial College Faculty of Medicine, London, GB
Eur J Immunol 32:1376-85. 2002Passage of helminth larvae through the lungs can cause pulmonary eosinophilia that may have evolved as a means of parasite attrition...
- Beta 2-microglobulin-dependent T cells are dispensable for allergen-induced T helper 2 responsesY Zhang
Department of Pediatrics, University of Washington, Seattle 98195, USA
J Exp Med 184:1507-12. 1996..OVA-treated beta 2m -/- mice had circulating levels of total and OVA-specific IgE, pulmonary eosinophilia, and expression of IL-4, IL-5, and IL-13 mRNA in bronchial lymph node tissue similar to that of OVA-..
- Identification of R146225 as a novel, orally active inhibitor of interleukin-5 biosynthesisJ Van Wauwe
Janssen Research Foundation, Beerse, Belgium
J Pharmacol Exp Ther 295:655-61. 2000..azauracil derivative, as a potent, orally active inhibitor of IL-5 biosynthesis, capable of reducing pulmonary eosinophilia in mice...
- Lung tissue eosinophils may be cleared through luminal entry rather than apoptosis: effects of steroid treatmentL Uller
Department of Physiological Sciences, University Hospital, Lund, Sweden
Am J Respir Crit Care Med 164:1948-56. 2001....
- Critical role for IL-13 in the development of allergen-induced airway hyperreactivityD M Walter
Division of Immunology and Allergy, Department of Pediatrics, Stanford University, Stanford, CA 94305, USA
J Immunol 167:4668-75. 2001..Therefore, treatment of human asthma with antagonists of IL-13 may be very effective...
- Acute eosinophilic pneumonia in a New York City firefighter exposed to World Trade Center dustWilliam N Rom
Division of Pulmonary and Critical Care Medicine, Department of Medicine, New York University School of Medicine, New York 10016, USA
Am J Respir Crit Care Med 166:797-800. 2002..Acute eosinophilic pneumonia is a rare consequence of acute high dust exposure. World Trade Center dust consists of large particle-size silicates, but fly ash and asbestos fibers may be found in bronchoalveolar lavage cells...
- The role of CD23 on allergen-induced IgE levels, pulmonary eosinophilia and bronchial hyperresponsiveness in miceY Riffo-Vasquez
The Sackler Institute of Pulmonary Pharmacology, Division of Pharmacology and Therapeutics, GKT School of Biomedical Sciences, King s College London, UK
Clin Exp Allergy 30:728-38. 2000....
- CD4 T-helper cells engineered to produce IL-10 prevent allergen-induced airway hyperreactivity and inflammationJae Won Oh
Division of Immunology and Allergy, Department of Pediatrics, Stanford University, CA 94305, USA
J Allergy Clin Immunol 110:460-8. 2002..T(H)2 cells play a critical role in the pathogenesis of asthma, but the precise immunologic mechanisms that inhibit T(H)2 cell function in vivo are not well understood...
- Chronic eosinophilic pneumonia due to visceral larva migransKoji Inoue
Department of Internal Medicine, National Kinki Chuo Hospital for Chest Diseases, Sakai, Osaka
Intern Med 41:478-82. 2002....
- Ectopic expression of IL-5 identifies an additional CD4(+) T cell mechanism of airway eosinophil recruitmentJeffrey R Crosby
Division of Hematology Oncology, Department of Biochemistry and Molecular Biology, Mayo Clinic Scottsdale, Scottsdale, Arizona 85259, USA
Am J Physiol Lung Cell Mol Physiol 282:L99-108. 2002..1726 CD4(-/-) mice, suggesting that eosinophil trafficking during allergic inflammatory responses is a consequence of a CD4(+) cell-mediated event(s) in addition to IL-5 expression and the establishment of a pulmonary chemokine gradient...
- CC chemokine receptor-2 is not essential for the development of antigen-induced pulmonary eosinophilia and airway hyperresponsivenessJ A MacLean
Center for Immunology and Inflammatory Disease, Division of Rheumatology, Allergy, and Immunology, Massachusetts General Hospital, Pulmonary and Critical Care Divisions, Brigham and Women s Hospital, Boston, MA 02114, USA
J Immunol 165:6568-75. 2000..repeated airway challenges with Ag in sensitized mice, the development of Th2 responses (elevated IgE, pulmonary eosinophilia, and lung cytokine levels of IL-4 and IL5) and the development of airway hyper-responsiveness are not ..
- Antieosinophilic activity of simendansHannu Kankaanranta
The Immunopharmacology Research Group, Medical School, University of Tampere, Finland
J Pharmacol Exp Ther 323:31-8. 2007..The aim of the present study was to evaluate whether simendans reduce pulmonary eosinophilia and regulate eosinophil apoptosis...
- A novel transcription factor inhibitor, SP100030, inhibits cytokine gene expression, but not airway eosinophilia or hyperresponsiveness in sensitized and allergen-exposed ratT J Huang
Thoracic Medicine, Chang Gung Memorial Hospital, Keelung Branch, Taiwan, Republic of China
Br J Pharmacol 134:1029-36. 2001..5. The joint AP-1 and NF-kappa B inhibitor, SP100030, selectively inhibits CD8(+) T-cells, and mRNA expression of both Th1 and Th2 cytokines in vivo, but does not inhibit allergen-induced airway eosinophilia and BHR...
- Inhaled p38alpha mitogen-activated protein kinase antisense oligonucleotide attenuates asthma in miceWei Duan
Department of Pharmacology, Faculty of Medicine, National University of Singapore, MD2, 18 Medical Drive, Singapore 117597
Am J Respir Crit Care Med 171:571-8. 2005..Nose-only aerosol exposure of mice verified the p38alpha-ASO-induced inhibition of OVA-induced pulmonary eosinophilia, mucus hypersecretion, and airway hyperresponsiveness...
- Eosinophils promote allergic disease of the lung by regulating CD4(+) Th2 lymphocyte functionJ R MacKenzie
Division of Biochemistry and Molecular Biology, John Curtin School of Medical Research, Australian National University, Canberra, Australia
J Immunol 167:3146-55. 2001..This investigation highlights the potential of eosinophils to not only act as terminal effector cells but also to actively modulate allergic inflammation by amplifying Th2 cell responses...
- Resolution of airway inflammation following ovalbumin inhalation: comparison of ISS DNA and corticosteroidsReid K Ikeda
Department of Medicine, University of California San Diego, La Jolla, CA 92093 0635, USA
Am J Respir Cell Mol Biol 28:655-63. 2003..The combination of the shared and distinct anti-inflammatory pathways may account for the additive effect of ISS and corticosteroids on inhibiting AHR...
- ROLE OF MUC1 IN THE GENESIS OF ALLERGIC ASTHMAKwang Chul Kim; Fiscal Year: 2010..Interestingly, our recent preliminary studies suggest that Muc1-null mice fail to exhibit pulmonary eosinophilia and goblet cell hyperplasia as seen in wild type littermates in an ovalbumin (OVA)-induced asthma model...
- A Novel Model of, and Pre-clinical Therapy for, Scleroderma Lung DiseaseSergei P Atamas; Fiscal Year: 2012..For example, while causing the mentioned changes resembling of human SLD, mIL-442 does not induce pulmonary eosinophilia or goblet cell hyperplasia (the features that are common in asthma but not in SLD, and that are readily ..
- A Mucosal RSV VaccineKejian Yang; Fiscal Year: 2013..to suffer from enhanced disease severity and even death upon subsequent RSV infection concomitant with pulmonary eosinophilia. Severe lung inflammatory responses characterized by a skewed CD4+ T-cell response (in the absence of ..
- PARTICIPATION OF PARP-1 IN THE PATHOGENESIS OF ASTHMAHamid Boulares; Fiscal Year: 2013..Asthma is, in part, a Th2 lymphocyte-mediated inflammatory airway disease characterized by pulmonary eosinophilia and airway hyper-responsiveness (AHR)...
- Mouse Models of Eosinophil-Associated Lung DysfunctionNancy A Lee; Fiscal Year: 2013..we have demonstrated that all of the pathologies in I5/hE2 mice are absolutely dependent on the induced pulmonary eosinophilia. This proposal capitalizes on the availability of the I5/hE2 transgenic model as well as our unique ..
- ST6Gal-1 Sialyltransferase in Allergic Airway InflammationJoseph T Y Lau; Fiscal Year: 2010..Expression of recombinant ST6Gal-1 in vivo can attenuate the pulmonary eosinophilia, suggesting a therapeutic potential for ST6Gal-1...
- Eosinophil-Airway Epithelial Fas-FasL InteractionsKimm Hamann; Fiscal Year: 2004..infiltrates such as eosinophils, and that in asthma this function is impaired contributing to persistent pulmonary eosinophilia. These studies will address molecular mechanisms which regulate the functional expression of FasL on ..
- CYTOKINE REGULATION OF A MOUSE MODEL OF ASTHMAFred Finkelman; Fiscal Year: 2003..eosinophils to the lungs, the mechanism by which TGF-alpha acts synergistically with IL-4 to induce pulmonary eosinophilia and the mechanism by which IL-12 inhibits IL-4 induced pulmonary eosinophilia...
- MOLECULAR BIOLOGY OF HUMAN FILARIAL PARASITESTHIRUCHANDURAI RAJAN; Fiscal Year: 1990..We have used a serum from a patient suffering from Tropical Pulmonary Eosinophilia (TPE) to isolate several reactive gt-11 clones and have sequenced the inserts in two of them...
- Eosinophil Regulation of Pulmonary IL-13 LevelsElizabeth Jacobsen; Fiscal Year: 2007..correlation between the pathologies associated with allergic respiratory inflammation and the accompanying pulmonary eosinophilia the specific role(s) of eosinophils and/or eosinophil effector functions (EEFs) in asthma are poorly ..
- Early Immune Events in Childhood AsthmaLisa Miller; Fiscal Year: 2009..Thus, our central hypothesis is that pulmonary eosinophilia is a critical first step in the initiation of allergic airways disease during postnatal development;..
- T CELLS & CHEMOKINES IN ALLERGIC PULMONARY INFLAMMATIONJames Maclean; Fiscal Year: 2000..3) To determine the effect of neutralizing eotaxin in vivo, on antigen-induced pulmonary eosinophilia and airways hyperresponsiveness in a murine model of antigen-induced pulmonary eosinophilia...
- Oxidative stress in asthma initiationSanjiv Sur; Fiscal Year: 2010..Future studies of POPAC may identify novel therapeutic approaches in asthma. ..
- Towards a better understanding of work-aggravated asthmaCatherine Lemiere; Fiscal Year: 2009..The occurrence of asthma exacerbations will be recorded. The economic impact of WAA will be assessed in terms of work disability and use of health resources and compared with OA and asthma without OA not WAA. ..
- Asthma Clinical Research Network-Washington UniversityMario Castro; Fiscal Year: 2007..We propose that it is only through such a collaboration that important questions regarding current and novel therapies and management of asthma can be answered. ..
- Role of Oxylipins in Cryptococcal PathogenesisGARY HUFFNAGLE; Fiscal Year: 2008..production; (3) to determine the role of the fungal oxylipin CnPGEx in cryptococcal biology and pathogenesis; (4) to determine the role of host PGE2 and other prostaglandins in cryptococcal biology and host immunity ..
- T CELL CONTROL OF AIRWAY MUCUS PRODUCTIONLauren Cohn; Fiscal Year: 2009..AIM II. Determine the mechanism of IFN-g inhibition of eosinophilia and its relationship to the reciprocal induction of neutrophilia. AIM III. Determine how IFN-g regulates the number of Th2 cells in the respiratory tract. ..
- Role of Fungal Microflora in Mucosal Tolerance/ImmunityGARY HUFFNAGLE; Fiscal Year: 2009..These studies will provide the basic science foundation for future studies in humans for understanding how and why manipulation of the microflora (by diet or probiotics) can alter or prevent allergies. ..
- Monoclonal antibodies to inhibit Aspergillus germinationMARTA L FELDMESSER; Fiscal Year: 2010..It is anticipated that this study will identify fungal molecules important for germination and begin to define their interaction with host immune responses. ..
- FLT3-LIGAND, IMMUNOMODULATION AND THERAPY IN ASTHMADEVENDRA AGRAWAL; Fiscal Year: 2008..The long-term goal of this study is to better define the potential mechanisms of action of FL to prevent and reverse allergic airway inflammation and associated changes in pulmonary function. ..
- TGF-BETA, CHLORIDE CHANNELS AND APOPTOSIS OF AIRWAY EPITHELIAL CELLSDevendra K Agrawal; Fiscal Year: 2010..Such investigations would provide unique insights to the pathophysiologic process of chronic asthma and the means to prevent or reverse the disease. ..
- Aquaporin 5 (AQP5) in Lung Fluid HomeostasisCARISSA KRANE; Fiscal Year: 2004..This combinatorial approach will provide valuable information for the identification of new mechanistic pathways critical for the development of novel drug targets for the treatment of asthma. ..
- Monoclonal antibodies for invasive aspergillosisMarta Feldmesser; Fiscal Year: 2003..To determine the biological activity of MAbs generated in Aim 2 in murine models of invasive aspergillosis. It is anticipated that this study will identify important targets for further investigation. ..
- INFLAMMATION & CORTICOSTEROID RESPONSES IN SEVERE ASTHMAKIAN CHUNG; Fiscal Year: 2005..The molecular mechanisms underlying loss of CR will be examined. These studies should lead to more effective therapies for chronic severe asthma. ..
- Biomarkers in sputum in COPDDavid Broide; Fiscal Year: 2005..abstract_text> ..
- RSV AND ASTHMADavid Broide; Fiscal Year: 2003..Overall these studies will contribute to our understanding of the mechanism of eosinophilic inflammation during RSV infection and suggest candidate vaccine strategies to inhibit RSV infection and airway inflammation. ..
- GENETIC, BIOLOGIC, & IMMUNOLOGIC DETERMINANTS OF ASTHMAMario Castro; Fiscal Year: 2006..abstract_text> ..
- Aspergillosis: Engineering Antibody for DiagnosisMarta Feldmesser; Fiscal Year: 2006..The availability of reagents that have potential to improve both sensitivity and specificity of galactomannan detection would be a significant advance. ..
- MODULATION OF TH1/TH2 RESPONSES BY INNATE IMMUNITYGARY HUFFNAGLE; Fiscal Year: 2004..One of the potential implications of these studies is that therapies inhibiting melanin biosynthesis or activity may also have an adjuvant effect and promote the development of protective Th1 immunity to C. neoformans. ..
- CHEMOKINE RECEPTORS IN IMMUNITY TO C NEOFORMANSGARY HUFFNAGLE; Fiscal Year: 2003..neoformans infection; (5) To determine the role of MCP-1 and CCR2 in the development of a Th2 response to C. neoformans. ..
- Asthma Induction by Dendritic Cells and Th2 CellsSun Sang Sung; Fiscal Year: 2007..The results may provide additional therapeutic strategies in asthma by the interference of SLC functions and by regulating the migration of DC, Th1, and IFN-gamma-producing CD8+ T cells. ..
- Role of the Leukotriene B4 Receptors in AsthmaBENJAMIN MEDOFF; Fiscal Year: 2003..Repeat experiments in the presence of a BLTR2 antagonist will also allow characterization of the role of this receptor in asthma. ..
- New York University School of Medicine CTSA Planning GrantWilliam Rom; Fiscal Year: 2006..unreadable] [unreadable] [unreadable]..
- Eosinophil TraffickingDavid Broide; Fiscal Year: 2005..Overall, these studies should improve our understanding of the molecular mechanism of eosinophil recruitment in vivo and its effect on airway structure and function. ..
- ENDOTHELIUM--SIGNALING FROM MAST CELLS TO EOSINOPHILSDavid Broide; Fiscal Year: 2002....
- Airway Remodeling in Severe AsthmaMario Castro; Fiscal Year: 2005..The identification of the potential variables associated with remodeling and severe asthma will help identify individuals at risk who would benefit from specific targeted therapy. ..
- Chemokines in lung transplantationBENJAMIN MEDOFF; Fiscal Year: 2007..abstract_text> ..
- The Reliability of the Placebo Effect in AsthmaMichael Wechsler; Fiscal Year: 2007..unreadable] [unreadable]..
- Polymorphisms of Neural NOS and the Asthma PhenotypeMichael Wechsler; Fiscal Year: 2005....
- HOST RESPONSE TO TB AND AIDSWilliam Rom; Fiscal Year: 2006..This study is critical in developing efficacious treatment strategies for TB and demonstrating that rIFN-gamma ameliorates the lung fibrosis and destruction in advanced TB. ..
- IMMUNE RESPONSE IN THE LUNG TO TB PROTEINS IN AIDSWilliam Rom; Fiscal Year: 2002..tb. proteins in PBMCs and BAL. This proposal will provide critical information on memory immunity in the lung when humans are infected/exposed to M. tb. and how this "protective" immune response to TB may be perturbated in AIDS. ..