pulmonary eosinophilia

Summary

Summary: A disease characterized by pulmonary infiltrations of eosinophils and blood eosinophilia.

Top Publications

  1. pmc Contribution of IL-33-activated type II innate lymphoid cells to pulmonary eosinophilia in intestinal nematode-infected mice
    Koubun Yasuda
    Department of Immunology and Medical Zoology, Hyogo College of Medicine, Nishinomiya 663 8501, Japan
    Proc Natl Acad Sci U S A 109:3451-6. 2012
  2. pmc Interleukin-17 drives pulmonary eosinophilia following repeated exposure to Aspergillus fumigatus conidia
    Benjamin J Murdock
    Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, University of Michigan Medical School, Ann Arbor, Michigan, USA
    Infect Immun 80:1424-36. 2012
  3. pmc Virus-specific CD8+ T lymphocytes downregulate T helper cell type 2 cytokine secretion and pulmonary eosinophilia during experimental murine respiratory syncytial virus infection
    A Srikiatkhachorn
    Beirne B Carter Center for Immunology Research, University of Virginia Health Sciences Center, Charlottesville 22908, USA
    J Exp Med 186:421-32. 1997
  4. ncbi Marked airway eosinophilia prevents development of airway hyper-responsiveness during an allergic response in IL-5 transgenic mice
    Takao Kobayashi
    Division of Allergic Diseases, Department of Internal Medicine, Mayo Clinic, Rochester, MN 55905, USA
    J Immunol 170:5756-63. 2003
  5. ncbi Eosinophilic lung diseases: diagnostic accuracy of thin-section CT in 111 patients
    T Johkoh
    Dept of Radiology, Osaka Univ Medical School, Suita, Japan
    Radiology 216:773-80. 2000
  6. ncbi A mouse model of airway disease: oncostatin M-induced pulmonary eosinophilia, goblet cell hyperplasia, and airway hyperresponsiveness are STAT6 dependent, and interstitial pulmonary fibrosis is STAT6 independent
    Dominik K Fritz
    Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada
    J Immunol 186:1107-18. 2011
  7. ncbi IL-13 induces eosinophil recruitment into the lung by an IL-5- and eotaxin-dependent mechanism
    S M Pope
    Division of Pulmonary Medicine, Allergy and Clinical Immunology, Department of Pediatrics, Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    J Allergy Clin Immunol 108:594-601. 2001
  8. ncbi Acute eosinophilic pneumonia secondary to daptomycin: a report of three cases
    Becky A Miller
    Division of Infectious Diseases, Duke University Medical Center, Durham, North Carolina, USA
    Clin Infect Dis 50:e63-8. 2010
  9. pmc Localized eosinophil degranulation mediates disease in tropical pulmonary eosinophilia
    Laura O'Bryan
    National Institutes of Health, Bethesda, Maryland, USA
    Infect Immun 71:1337-42. 2003
  10. pmc Reciprocal immunomodulatory effects of gamma interferon and interleukin-4 on filaria-induced airway hyperresponsiveness
    R K Mehlotra
    Division of Geographic, Department of Medicine, Case Western Reserve University, Cleveland, Ohio 44106, USA
    Infect Immun 69:1463-8. 2001

Research Grants

  1. ROLE OF MUC1 IN THE GENESIS OF ALLERGIC ASTHMA
    Kwang Chul Kim; Fiscal Year: 2010
  2. A Novel Model of, and Pre-clinical Therapy for, Scleroderma Lung Disease
    Sergei P Atamas; Fiscal Year: 2012
  3. A Mucosal RSV Vaccine
    Kejian Yang; Fiscal Year: 2013
  4. PARTICIPATION OF PARP-1 IN THE PATHOGENESIS OF ASTHMA
    Hamid Boulares; Fiscal Year: 2013
  5. Mouse Models of Eosinophil-Associated Lung Dysfunction
    Nancy A Lee; Fiscal Year: 2013
  6. ST6Gal-1 Sialyltransferase in Allergic Airway Inflammation
    Joseph T Y Lau; Fiscal Year: 2010
  7. Eosinophil-Airway Epithelial Fas-FasL Interactions
    Kimm Hamann; Fiscal Year: 2004
  8. CYTOKINE REGULATION OF A MOUSE MODEL OF ASTHMA
    Fred Finkelman; Fiscal Year: 2003
  9. MOLECULAR BIOLOGY OF HUMAN FILARIAL PARASITES
    THIRUCHANDURAI RAJAN; Fiscal Year: 1990
  10. Eosinophil Regulation of Pulmonary IL-13 Levels
    Elizabeth Jacobsen; Fiscal Year: 2007

Detail Information

Publications200 found, 100 shown here

  1. pmc Contribution of IL-33-activated type II innate lymphoid cells to pulmonary eosinophilia in intestinal nematode-infected mice
    Koubun Yasuda
    Department of Immunology and Medical Zoology, Hyogo College of Medicine, Nishinomiya 663 8501, Japan
    Proc Natl Acad Sci U S A 109:3451-6. 2012
    ..Finally, IL-33-stimulated NH cells induce lung eosinophilic inflammation and might aid to expel infected worms in the lungs...
  2. pmc Interleukin-17 drives pulmonary eosinophilia following repeated exposure to Aspergillus fumigatus conidia
    Benjamin J Murdock
    Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, University of Michigan Medical School, Ann Arbor, Michigan, USA
    Infect Immun 80:1424-36. 2012
    ..These observations point to an expanded role for IL-17 in driving T(H)2-type inflammation to repeated inhalation of fungal conidia...
  3. pmc Virus-specific CD8+ T lymphocytes downregulate T helper cell type 2 cytokine secretion and pulmonary eosinophilia during experimental murine respiratory syncytial virus infection
    A Srikiatkhachorn
    Beirne B Carter Center for Immunology Research, University of Virginia Health Sciences Center, Charlottesville 22908, USA
    J Exp Med 186:421-32. 1997
    ..to RSV-G (attachment) glycoprotein exhibit a strong interleukin (IL)-4 and IL-5 response and develop pulmonary eosinophilia, whereas mice sensitized to RSV-F (fusion) glycoprotein develop a predominantly T helper cell (Th)1 ..
  4. ncbi Marked airway eosinophilia prevents development of airway hyper-responsiveness during an allergic response in IL-5 transgenic mice
    Takao Kobayashi
    Division of Allergic Diseases, Department of Internal Medicine, Mayo Clinic, Rochester, MN 55905, USA
    J Immunol 170:5756-63. 2003
    ..Overall, the roles of eosinophils in asthma and in animal models need to be addressed carefully for their potentially detrimental and beneficial effects...
  5. ncbi Eosinophilic lung diseases: diagnostic accuracy of thin-section CT in 111 patients
    T Johkoh
    Dept of Radiology, Osaka Univ Medical School, Suita, Japan
    Radiology 216:773-80. 2000
    ..To determine whether various eosinophilic lung diseases can be differentiated by means of thin-section computed tomography (CT)...
  6. ncbi A mouse model of airway disease: oncostatin M-induced pulmonary eosinophilia, goblet cell hyperplasia, and airway hyperresponsiveness are STAT6 dependent, and interstitial pulmonary fibrosis is STAT6 independent
    Dominik K Fritz
    Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada
    J Immunol 186:1107-18. 2011
    ..Thus, overexpression of mOSM induces STAT6-dependent pulmonary eosinophilia, mucous/goblet cell hyperplasia, and airway hyperresponsiveness but STAT6-independent mechanisms of lung ..
  7. ncbi IL-13 induces eosinophil recruitment into the lung by an IL-5- and eotaxin-dependent mechanism
    S M Pope
    Division of Pulmonary Medicine, Allergy and Clinical Immunology, Department of Pediatrics, Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    J Allergy Clin Immunol 108:594-601. 2001
    ..IL-13 induces several characteristic features of asthma, including airway eosinophilia, airway hyperresponsiveness, and mucus overproduction; however, the mechanisms involved are largely unknown...
  8. ncbi Acute eosinophilic pneumonia secondary to daptomycin: a report of three cases
    Becky A Miller
    Division of Infectious Diseases, Duke University Medical Center, Durham, North Carolina, USA
    Clin Infect Dis 50:e63-8. 2010
    ..Clinical suspicion for this adverse drug event and cessation of daptomycin until definitive diagnosis can be made is crucial...
  9. pmc Localized eosinophil degranulation mediates disease in tropical pulmonary eosinophilia
    Laura O'Bryan
    National Institutes of Health, Bethesda, Maryland, USA
    Infect Immun 71:1337-42. 2003
    To explore the mechanisms underlying the eosinophil-mediated inflammation of tropical pulmonary eosinophilia (TPE), bronchoalveolar lavage (BAL) fluid, serum, and supernatants from pulmonary and blood leukocytes (WBC) from patients with ..
  10. pmc Reciprocal immunomodulatory effects of gamma interferon and interleukin-4 on filaria-induced airway hyperresponsiveness
    R K Mehlotra
    Division of Geographic, Department of Medicine, Case Western Reserve University, Cleveland, Ohio 44106, USA
    Infect Immun 69:1463-8. 2001
    Tropical pulmonary eosinophilia (TPE) is a severe asthmatic syndrome of lymphatic filariasis, in which an allergic response is induced to microfilariae (Mf) in the lungs...
  11. ncbi Increased vascular endothelial growth factor in acute eosinophilic pneumonia
    Y Nishigaki
    Dept of Respiratory Medicine, National Dohoku Hospital, Asahikawa, Japan
    Eur Respir J 21:774-8. 2003
    ....
  12. ncbi Tropical pulmonary eosinophilia: analysis of antifilarial antibody localized to the lung
    T B Nutman
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892
    J Infect Dis 160:1042-50. 1989
    Acute tropical pulmonary eosinophilia (TPE) is characterized by wheezing, pulmonary infiltrates, marked peripheral blood eosinophilia, and very high serum levels of filaria-specific antibodies...
  13. pmc Pulmonary eosinophilia requires interleukin-5, eotaxin-1, and CD4+ T cells in mice immunized with respiratory syncytial virus G glycoprotein
    Teresa R Johnson
    Vaccine Research Center, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, MD 20892 3017, USA
    J Leukoc Biol 84:748-59. 2008
    Severe illness, type 2 cytokine production, and pulmonary eosinophilia are adverse immune responses resulting from respiratory syncytial virus (RSV) challenge of vvGs-immunized mice...
  14. ncbi FICZ, a tryptophan photoproduct, suppresses pulmonary eosinophilia and Th2-type cytokine production in a mouse model of ovalbumin-induced allergic asthma
    Kyu Tae Jeong
    Department of Biology, Changwon National University, Changwon, Kyungnam 641 773, Korea
    Int Immunopharmacol 13:377-85. 2012
    ..FICZ significantly reduced pulmonary eosinophilia and Th2 cytokine expression in the lungs...
  15. ncbi Chlorogenic acid suppresses pulmonary eosinophilia, IgE production, and Th2-type cytokine production in an ovalbumin-induced allergic asthma: activation of STAT-6 and JNK is inhibited by chlorogenic acid
    Hye Rin Kim
    Department of Biology, Changwon National University, 9, Sarim dong, Changwon, Kyungnam 641 773, South Korea
    Int Immunopharmacol 10:1242-8. 2010
    ..CGA significantly reduced pulmonary eosinophilia and expression of IL-4, IL-5 and TNF-α in the lung as well as the serum levels of total and OVA-specific ..
  16. ncbi Idiopathic acute eosinophilic pneumonia: a study of 22 patients
    Francois Philit
    Service d Assistance Respiratoire et Réanimation Médicale, Hopital de la Croix Rousse, Paris, France
    Am J Respir Crit Care Med 166:1235-9. 2002
    ..is characterized by acute febrile respiratory failure associated with diffuse radiographic infiltrates and pulmonary eosinophilia. We conducted a multicenter retrospective study to characterize this rare clinical entity further and to ..
  17. ncbi Suppression of asthma-like responses in different mouse strains by oral tolerance
    M Russo
    Departamento de Imunologia, Instituto de Ciencias Biomedicas, Universidade de Sao Paulo, Sao Paulo, Brazil
    Am J Respir Cell Mol Biol 24:518-26. 2001
    ..Collectively, our findings show for the first time the beneficial and detrimental effects of oral Ag administration on the development of experimental asthma...
  18. ncbi Prostaglandin D2-induced eosinophilic airway inflammation is mediated by CRTH2 receptor
    Yoshiki Shiraishi
    Division of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    J Pharmacol Exp Ther 312:954-60. 2005
    ..These results suggest that CRTH2 plays a significant role in the eosinophil trafficking from the bloodstream into the airways in PGD(2)-related airway inflammation...
  19. ncbi Inhibition of pulmonary eosinophilia in P-selectin- and ICAM-1-deficient mice
    D H Broide
    Department of Medicine, University of California at San Diego, 92093 0635, USA
    Am J Respir Cell Mol Biol 18:218-25. 1998
    ..These studies suggest an important role for ICAM-1 and P-selectin in eosinophil recruitment to the lung after allergen challenge...
  20. ncbi Pulmonary eosinophilia
    Luiz Eduardo Mendes Campos
    Residency Program in Pulmonology and Respiratory Outpatient Clinic Júlia Kubitschek Hospital, Fundação Hospitalar do Estado de Minas Gerais FHEMIG, Hospital Foundation of the State of Minas Gerais Belo Horizonte, Brazil
    J Bras Pneumol 35:561-73. 2009
    b>Pulmonary eosinophilia comprises a heterogeneous group of diseases defined by eosinophilia in pulmonary infiltrates (bronchoalveolar lavage fluid) or in tissue (lung biopsy specimens)...
  21. ncbi Effects of steroid therapy on inflammatory cell subtypes in asthma
    Douglas C Cowan
    Dunedin School of Medicine, University of Otago, P O Box 913, Dunedin, New Zealand
    Thorax 65:384-90. 2010
    ..ICS use led to phenotype misclassification. Steroid responsiveness was greater in EA, but the absence of eosinophilia did not indicate the absence of a steroid response. In NEA this was best predicted by baseline exhaled nitric oxide...
  22. ncbi The JAK-3 inhibitor CP-690550 is a potent anti-inflammatory agent in a murine model of pulmonary eosinophilia
    Elizabeth Kudlacz
    Pfizer Global Research and Development, New London, CT 06320, USA
    Eur J Pharmacol 582:154-61. 2008
    ..The importance of IL-4 in the development of pulmonary eosinophilia was supported by a marked (90%) reduction in the influx of these cells in IL-4KO mice similarly sensitized ..
  23. ncbi IL-13 is required for eosinophil entry into the lung during respiratory syncytial virus vaccine-enhanced disease
    Elaine M Castilow
    Interdisciplinary Graduate Program in Immunology, University of Iowa, 51 Newton Road, Iowa City, IA 52242, USA
    J Immunol 180:2376-84. 2008
    ..Eosinophils are characteristic of Th2 responses, and Th2 cells are known to be necessary to induce pulmonary eosinophilia in RSV-infected BALB/c mice previously immunized with a recombinant vaccinia virus (vv) expressing the RSV ..
  24. pmc Characterization of recombinant respiratory syncytial viruses with the region responsible for type 2 T-cell responses and pulmonary eosinophilia deleted from the attachment (G) protein
    Matthew B Elliott
    Department of Immunology, Wyeth Vaccines Research, 401 N Middletown Rd, Pearl River, NY 10965, USA
    J Virol 78:8446-54. 2004
    ..9-log(10)-unit reduction in RSV A2 levels 4 days after challenge. Importantly, pulmonary eosinophilia was significantly diminished in BALB/c mice primed with native G protein and challenged with either ..
  25. ncbi Chronic eosinophilic pneumonia: a case report and national survey
    Catherine Wubbel
    Department of Pediatrics, University of Florida College of Medicine, Gainesville 32610, USA
    Chest 123:1763-6. 2003
    ..The survey showed a low prevalence of acute eosinophilic pneumonia and CEP in the pediatric population, with an overall male/female ratio of 1.6:1...
  26. ncbi [Diagnosis of non-parasitic hypereosinophilia]
    Jean Emmanuel Kahn
    Service de Medecine Interne, Hopital Foch, Suresnes
    Presse Med 35:144-52. 2006
    ..Corticosteroids are the first-line therapy. Mepolizumab, an anti-IL-5 monoclonal antibody, currently being evaluated, seems promising. Despite recent progress, about 40% of the cases of hypereosinophilic syndrome remain unexplained...
  27. ncbi Eosinophilic interstitial lung disease
    W Michael Alberts
    H Lee Moffitt Cancer Center and the Department of Interdisciplinary Oncology, University of South Florida College of Medicine, Tampa, Florida 33612, USA
    Curr Opin Pulm Med 10:419-24. 2004
    ..This review and update will concentrate on the latter group of entities...
  28. pmc Cyclosporin A increases the pulmonary eosinophilia induced by inhaled Aspergillus antigen in mice
    J M Wang
    Unite de Recherche, Centre de Pneumologie de l Hôpital Laval, Quebec, Canada
    Clin Exp Immunol 93:323-30. 1993
    ..fumigatus. The effect of CsA on this inflammatory response was paradoxical, insofar as it suggests an activation of the T helper 2 subset, which up-regulates eosinophil recruitment and IgE production...
  29. ncbi Establishment of airway eosinophilic bronchitis mouse model without hyperresponsiveness by ovalbumin
    Liyan Chen
    State Key Laboratory of Respiratory Diseases, Guangzhou Medical College, 151 Yanjiang Road, 510120 GuangZhou, Guangdong, China
    Clin Exp Med 11:19-24. 2011
    ..A mouse model of EB without AHR can be established by 10 μg OVA challenge and provides a useful tool for studying AHR mechanisms...
  30. ncbi Clinical findings, bronchoalveolar lavage fluid cytology and matrix metalloproteinase-2 and -9 in canine pulmonary eosinophilia
    Minna M Rajamäki
    Department of Clinical Veterinary Sciences, Faculty of Veterinary Medicine, University of Helsinki, Finland
    Vet J 163:168-81. 2002
    ..features, and the involvement of gelatinolytic matrix metalloproteinases (MMP-2 and -9) in canine pulmonary eosinophilia (PE). Study material consisted of 20 PE dogs and 16 healthy beagles...
  31. ncbi Tropical pulmonary eosinophilia
    Jean Francois Magnaval
    Clin Infect Dis 40:635-6. 2005
  32. pmc Pulmonary eosinophilia is attenuated by early responding CD8(+) memory T cells in a murine model of RSV vaccine-enhanced disease
    Whitney W Stevens
    Beirne B Carter Center for Immunology Research, University of Virginia, Charlottesville, Virginia 22908, USA
    Viral Immunol 22:243-51. 2009
    ..to mount an effective CD8(+) memory T-cell (CD8(+) Tm) response in this model could account for the pulmonary eosinophilia associated with the development of enhanced disease, and that CD8(+) T cells may control the development ..
  33. pmc Enhanced disease and pulmonary eosinophilia associated with formalin-inactivated respiratory syncytial virus vaccination are linked to G glycoprotein CX3C-CX3CR1 interaction and expression of substance P
    Lia M Haynes
    Division of Viral and Rickettsial Diseases, National Center of Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    J Virol 77:9831-44. 2003
    ..Enhanced pulmonary disease is characterized by pulmonary eosinophilia and is associated with a substantial inflammatory response...
  34. pmc Airway allergen exposure stimulates bone marrow eosinophilia partly via IL-9
    Brigita Sitkauskiene
    The Lung Pharmacology Group, Department of Respiratory Medicine and Allergology, Institute of Internal Medicine, Goteborg University, Guldhedsgatan 10A, 413 46 Gothenburg, Sweden
    Respir Res 6:33. 2005
    ..We aimed to evaluate the therapeutic effect of a neutralizing anti-IL-9 antibody in a mouse model of airway eosinophilic inflammation and compared any such effect with anti-IL-5 treatment...
  35. ncbi Idiopathic chronic eosinophilic pneumonia and asthma: how do they influence each other?
    E Marchand
    Centre d Etudes et de Recherche sur les Maladies Orphelines Pulmonaires, Hopital Cardiovasculaire et Pneumologique Louis Pradel, Universite Claude Bernard, Hospices Civils de Lyon, France
    Eur Respir J 22:8-13. 2003
    ..The occurrence of idiopathic chronic eosinophilic pneumonia in asthmatics is often associated with the development of severe asthma...
  36. ncbi Understanding respiratory syncytial virus (RSV) vaccine-enhanced disease
    Elaine M Castilow
    Interdisciplinary Graduate Program in Immunology, University of Iowa, 3 532 Bowen Science Building, 51 Newton Road, Iowa City, IA 52242, USA
    Immunol Res 39:225-39. 2007
    ..previously immunized with a formalin-inactivated (FI)-RSV vaccine is associated with enhanced disease and pulmonary eosinophilia that is believed to be due to an exaggerated memory Th2 response...
  37. ncbi Transient pulmonary eosinophilia incidentally found on low-dose computed tomography: findings in 40 individuals
    Hyae Young Kim
    Department of Radiology, Center for Lung Cancer, Research Institute and Hospital, National Cancer Center, Gyeonggi Do, Korea
    J Comput Assist Tomogr 32:101-7. 2008
    To describe computed tomography (CT) findings of transient pulmonary eosinophilia (TPE) incidentally found on low-dose CT (LDCT) and to identify suggestive CT features helpful in initial diagnosis.
  38. ncbi Localisation and distribution of Wuchereria bancrofti antigens recognised by antisera from tropical pulmonary eosinophilia and from individuals with intestinal helminths
    C A Peixoto
    Department of Cellular Pathology and Biology, Research Center Aggeu Magalhães, Recife, Brazil
    J Submicrosc Cytol Pathol 35:61-8. 2003
    Serological analyses of sera from patients with a typical picture of filarial tropical pulmonary eosinophilia (TPE) and sera from patients from a region non-endemic for filariasis harbouring intestinal helminths, as Ascaris lumbricoides ..
  39. ncbi Tachykinin NK3-receptor deficiency does not inhibit pulmonary eosinophilia in allergic mice
    T T Kung
    Department of Allergy and Immunology, Schering Plough Research Institute, 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA
    Pharmacol Res 50:611-5. 2004
    ..These results find no role for tachykinin NK3-receptors on the pulmonary eosinophilia and lung damage after antigen challenge in mice.
  40. ncbi Parasitic pulmonary eosinophilia
    Rajinder K Chitkara
    Division of Pulmonary and Critical Care Medicine, Veterans Affairs Palo Alto Healthcare System, Stanford University School of Medicine, Palo Alto, California 94304, USA
    Semin Respir Crit Care Med 27:171-84. 2006
    ..b>Pulmonary eosinophilia occurs in almost all metazoan infections...
  41. ncbi A rho kinase inhibitor, Y-27632 inhibits pulmonary eosinophilia, bronchoconstriction and airways hyperresponsiveness in allergic mice
    Peter J Henry
    Pharmacology Unit, School of Medicine and Pharmacology, University of Western Australia, Perth 6009, Australia
    Pulm Pharmacol Ther 18:67-74. 2005
    ..These inhibitory effects of intranasal Y-27632 on pulmonary eosinophilia were accompanied by a significant inhibition of the development of airways hyperresponsiveness in allergic ..
  42. ncbi Multiple antigen challenge produces pulmonary eosinophilia but not pulmonary hyperresponsiveness in actively sensitized guinea pigs
    J W Watson
    Department of Immunology and Infectious Diseases, Pfizer Inc, Groton, CT 06340
    Agents Actions 37:174-7. 1992
    ..of actively sensitized boosted guinea pigs to aerosolized antigen, 3 times on alternate days, produced pulmonary eosinophilia but not pulmonary hyperresponsiveness to methacholine Cl measured 3 days after the last antigen challenge...
  43. ncbi Subcellular site of expression and route of vaccination influence pulmonary eosinophilia following respiratory syncytial virus challenge in BALB/c mice sensitized to the attachment G protein
    G P Bembridge
    Institute for Animal Health, Newbury, Berkshire, United Kingdom
    J Immunol 161:2473-80. 1998
    ..The induction of pulmonary eosinophilia in rVV-primed mice was also dependent upon the route of vaccination...
  44. pmc Circulating, but not local lung, IL-5 is required for the development of antigen-induced airways eosinophilia
    J Wang
    Immunology and Infection Program, Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada L8N 3Z5
    J Clin Invest 102:1132-41. 1998
    ..These findings also provide the rationale for developing strategies to target circulating IL-5 and/or its receptors in bone marrow to effectively control asthmatic airways eosinophilia...
  45. ncbi Pulmonary eosinophilia
    Uriel Katz
    Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    Clin Rev Allergy Immunol 34:367-71. 2008
    ..Migratory peripheral infiltrates are seen in the chest x-ray film. Both acute and chronic eosinophilic pneumonia are treated by glucocorticoids and respiratory support as well as avoidance of any recognized trigger...
  46. ncbi Interstitial lung disease induced by drugs and radiation
    Philippe Camus
    Department of Pulmonary and Intensive Care, University Medical Center Le Bocage and Medical School, Universite de Bourgogne, Dijon, France
    Respiration 71:301-26. 2004
    ..Rechallenge is justified in a minority of patients, and is discouraged for diagnostic purposes only. Pneumotox (www.pneumotox.com) provides updated information on drug-induced respiratory disease...
  47. pmc A role for CD44 in an antigen-induced murine model of pulmonary eosinophilia
    Shigeki Katoh
    Third Department of Internal Medicine, Miyazaki Medical College, Miyazaki, Japan
    J Clin Invest 111:1563-70. 2003
    ..We have used experimental pulmonary eosinophilia induced in mice by Ascaris suum (Asc) extract to investigate the role of CD44 in the development of ..
  48. ncbi CD4+CD25+ T cells regulate airway eosinophilic inflammation by modulating the Th2 cell phenotype
    Zeina Jaffar
    Center for Environmental Health Sciences, University of Montana, Missoula, MT 59812, USA
    J Immunol 172:3842-9. 2004
    ..Conceivably, this is partly a consequence of regulatory T cells facilitating the production of IL-10...
  49. pmc C57BL/6 mice are more susceptible to antigen-induced pulmonary eosinophilia than BALB/c mice, irrespective of systemic T helper 1/T helper 2 responses
    T Morokata
    Inflammation Research Pharmacology Laboratories, Institute for Drug Discovery Research, Yamanouchi Pharmaceutical Co Ltd, Ibaraki, Japan
    Immunology 98:345-51. 1999
    ..Therefore, local immune responses are more important in the induction of allergic inflammation in the lungs and are different from systemic immune responses, which are thought to depend on genetic background...
  50. ncbi Eosinophilic pneumonias
    V Cottin
    Department of Pulmonary Medicine, and Center for Orphan Lung Diseases, Louis Pradel University Hospital, Claude Bernard University, UMR 754 INRA ENVL UCBL and IFR128 Biosciences, Lyon, France
    Allergy 60:841-57. 2005
    ..The adjunction of immunosuppressants to corticosteroids is necessary in patients with CSS and poor prognosis factors. Imatinib has recently proven effective in the treatment of the myeloproliferative variant of the HES...
  51. ncbi Respiratory syncytial virus infection of gene gun vaccinated mice induces Th2-driven pulmonary eosinophilia even in the absence of sensitisation to the fusion (F) or attachment (G) protein
    G P Bembridge
    Institute for Animal Health, Compton, Newbury, RG20 7NN, Berkshire, UK
    Vaccine 19:1038-46. 2000
    ..In contrast, the BAL from mice vaccinated with control plasmid contained significantly more eosinophils than any other group...
  52. ncbi Tropical pulmonary eosinophilia: pathogenesis, diagnosis and management
    Vannan Kandi Vijayan
    Vallabhbhai Patel Chest Institute, University of Delhi, India
    Curr Opin Pulm Med 13:428-33. 2007
    Tropical pulmonary eosinophilia is predominantly seen in the tropical and subtropical regions of the world. It is being increasingly reported from other parts of world, however, due to increases in global travel and migration...
  53. ncbi Drug-, toxin-, and radiation therapy-induced eosinophilic pneumonia
    Joshua Solomon
    Department of Pulmonary Sciences and Critical Care Medicine, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Semin Respir Crit Care Med 27:192-7. 2006
    ..Radiation therapy has also been associated with the development of eosinophilic pneumonia in patients receiving this treatment for breast cancer...
  54. pmc An essential role for interleukin-5 and eosinophils in helminth-induced airway hyperresponsiveness
    L R Hall
    Divisions of Geographic, Department of Medicine, Case Western Reserve University, Cleveland, Ohio 44106, USA
    Infect Immun 66:4425-30. 1998
    ..parasitic helminth Brugia malayi can result in development of a severe asthmatic response termed tropical pulmonary eosinophilia. This disease, thought to result from a host inflammatory response to blood parasites which become trapped ..
  55. ncbi Hierarchical suppression of asthma-like responses by mucosal tolerance
    Alexandre C Keller
    Department of Immunology, Biomedical Science Institute, University of Sao Paulo, Brazil
    J Allergy Clin Immunol 117:283-90. 2006
    ..Mucosal tolerance can be induced by oral or nasal administration of soluble proteins and results in the suppression of cellular and/or humoral immune responses to the specific antigen...
  56. ncbi Sputum eosinophilia and short-term response to prednisolone in chronic obstructive pulmonary disease: a randomised controlled trial
    C E Brightling
    Institute for Lung Health, Department of Respiratory Medicine, Glenfield Hospital, Leicester, UK
    Lancet 356:1480-5. 2000
    ..Whether these patients have different airway pathology from other COPD patients is unclear. We tested the hypothesis that response to prednisolone is related to the presence of eosinophilic airway inflammation...
  57. pmc Differential role of gamma interferon in inhibiting pulmonary eosinophilia and exacerbating systemic disease in fusion protein-immunized mice undergoing challenge infection with respiratory syncytial virus
    Elaine M Castilow
    Interdisciplinary Graduate Program in Immunology, University of Iowa, Iowa City, IA 52242, USA
    J Virol 82:2196-207. 2008
    ..BALB/c mice with a recombinant vaccinia virus (vv) expressing the attachment (G) protein of RSV results in pulmonary eosinophilia upon RSV challenge, whereas immunization of mice with a vv expressing the fusion (F) protein does not...
  58. ncbi Immune responses to the nonglycosylated ectodomain of respiratory syncytial virus attachment glycoprotein mediate pulmonary eosinophilia in inbred strains of mice with different MHC haplotypes
    Gerald E Hancock
    Department of Immunology Research, Wyeth Vaccines, West Henrietta, New York 14586 9728, USA
    J Med Virol 70:301-8. 2003
    ..As demonstrated by IL-5-dependent pulmonary eosinophilia after challenge and serum anti-G protein IgG1 to IgG2 ratios, highly purified native G protein sensitized ..
  59. ncbi The eotaxin chemokines and CCR3 are fundamental regulators of allergen-induced pulmonary eosinophilia
    Samuel M Pope
    Division of Allergy and Immunology, Department of Pediatrics, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    J Immunol 175:5341-50. 2005
    ..These results imply that successful blockade of Ag-induced pulmonary eosinophilia will require antagonism of multiple CCR3 ligands.
  60. ncbi Mannitol challenge for assessment of airway responsiveness, airway inflammation and inflammatory phenotype in asthma
    L G Wood
    Respiratory and Sleep Medicine, Hunter Medical Research Institute, John Hunter Hospital, New Lambton, NSW, Australia
    Clin Exp Allergy 40:232-41. 2010
    ..Assessment of airway inflammation in asthma is becoming increasingly important, as the inflammatory phenotype underpins the treatment response...
  61. ncbi Tropical pulmonary eosinophilia
    E A Ottesen
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892
    Annu Rev Med 43:417-24. 1992
    Tropical pulmonary eosinophilia is one of the many PIE syndromes [pulmonary infiltrates with eosinophilia (of the peripheral blood)]...
  62. pmc Exhaled nitric oxide measurements: clinical application and interpretation
    D R Taylor
    Department of Medical and Surgical Sciences, Dunedin School of Medicine, University of Otago, P O Box 913, Dunedin, New Zealand
    Thorax 61:817-27. 2006
    ..However, a number of issues still need to be resolved, including the diagnostic role of F(E)NO in preschool children and the use of reference values versus individual F(E)NO profiles in managing patients with difficult or severe asthma...
  63. ncbi Genetic polymorphisms of eosinophil-derived neurotoxin and eosinophil cationic protein in tropical pulmonary eosinophilia
    Yae Jean Kim
    Laboratory of Malaria and Vector Research, Biostatistics Research Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Am J Trop Med Hyg 73:125-30. 2005
    ..neurotoxin (EDN) and eosinophil cationic protein (ECP) are critical in the pathogenesis of tropical pulmonary eosinophilia (TPE), we analyzed genetic polymorphisms of both in 181 individuals from southern India with varying ..
  64. pmc Simple pulmonary eosinophilia evaluated by means of FDG PET: the findings of 14 cases
    Tae Jung Kim
    Department of Radiology, Seoul National University Bundang Hospital, Gyeonggi Do, Korea
    Korean J Radiol 6:208-13. 2005
    We wanted to describe the findings of simple pulmonary eosinophilia with using 18 fluorodeoxyglucose (FDG) positron emission tomography (PET).
  65. ncbi A New York City firefighter: overwhelmed by World Trade Center dust
    William S Beckett
    Am J Respir Crit Care Med 166:785-6. 2002
  66. ncbi Elevated interleukin-18 levels in bronchoalveolar lavage fluid of patients with eosinophilic pneumonia
    S Katoh
    Third Department of Internal Medicine, Miyazaki Medical College, 5200 Kihara, Kiyotake, Miyazaki 889 1692, Japan
    Allergy 59:850-6. 2004
    ..To evaluate the role of IL-18 in the pathogenesis of EP, we measured the concentration of IL-2, IL-12, IL-18, and Th2 cytokines in BALF from patients with EP...
  67. ncbi Mouse model of airway remodeling: strain differences
    Kazuhiko Shinagawa
    Pharmacology Lab, Kissei Pharmaceutical Co Ltd, Minamiazumi, Nagano, Japan
    Am J Respir Crit Care Med 168:959-67. 2003
    ..In particular, useful qualitative and quantitative information relating to the structural and histologic changes in the lungs may be obtainable using this model...
  68. pmc Oral tolerance inhibits pulmonary eosinophilia in a cockroach allergen induced model of asthma: a randomized laboratory study
    Louis J Vaickus
    Boston University School of Medicine, Department of Pathology and Laboratory Medicine, Boston, MA, USA
    Respir Res 11:160. 2010
    ..In this study we endeavored to induce oral tolerance to cockroach allergen (CRA: a complex mixture of insect components) in order to ameliorate asthma-like, allergic pulmonary inflammation...
  69. ncbi Chronic cough: eosinophilic bronchitis without asthma
    P G Gibson
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Lancet 1:1346-8. 1989
    ..Airway inflammation with eosinophils and metachromatic cells is not always accompanied by increased airway responsiveness, and current definitions of obstructive airways disease may need to be revised...
  70. pmc C5 modulates airway hyperreactivity and pulmonary eosinophilia during enhanced respiratory syncytial virus disease by decreasing C3a receptor expression
    Guillermina A Melendi
    INFANT Fundacion, Buenos Aires, Argentina
    J Virol 81:991-9. 2007
    ..was characterized by immune complex-mediated airway hyperreactivity and a severe pneumonia associated with pulmonary eosinophilia. In this paper, we show that complement factors contribute to enhanced-disease phenotypes...
  71. ncbi Acute fibrinous and organizing pneumonia: a histological pattern of lung injury and possible variant of diffuse alveolar damage
    Mary Beth Beasley
    Department of Pulmonary, Armed Forces Institute of Pathology, Washington, DC 20306, USA
    Arch Pathol Lab Med 126:1064-70. 2002
    ....
  72. pmc Elevated immunoglobulin E against recombinant Brugia malayi gamma-glutamyl transpeptidase in patients with bancroftian filariasis: association with tropical pulmonary eosinophilia or putative immunity
    Edgar Lobos
    The Wolfson Institute for Biomedical Research, University College London, United Kingdom
    Infect Immun 71:747-53. 2003
    ..malayi, a homologue of gamma-glutamyl transpeptidase (gamma-GT), is involved in the pathology of tropical pulmonary eosinophilia (TPE) through its potent allergenicity and the induction of antibodies against the host pulmonary ..
  73. ncbi Suppression of allergen reactive Th2 mediated responses and pulmonary eosinophilia by intranasal administration of an immunodominant peptide is linked to IL-10 production
    Gillian Hall
    Respiratory Medicine Unit, Immunobiology Group, Rayne Laboratory, MRC Centre for Inflammation Research, University of Edinburgh Medical School, Teviot Place, Edinburgh EH8 9AG, UK
    Vaccine 21:549-61. 2003
    ..The mucosal administration of a peptide containing an immunodominant region of an allergen can protect against the induction of systemic and local inflammatory responses to allergen challenge...
  74. ncbi Acute eosinophilic pneumonia following cigarette smoking: a case report including cigarette-smoking challenge test
    Kazuyoshi Watanabe
    Department of Internal Medicine, Sinminato Municipal of Hospital, Sinminato
    Intern Med 41:1016-20. 2002
    ..After the challenge, eosinophilic pneumonia was documented by BALF and TBLB findings, which were similar to those detected on admission, without significant radiographic findings...
  75. ncbi Antisense therapy against CCR3 and the common beta chain attenuates allergen-induced eosinophilic responses
    Gail M Gauvreau
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Am J Respir Crit Care Med 177:952-8. 2008
    ....
  76. ncbi Acute eosinophilic pneumonia among US Military personnel deployed in or near Iraq
    Andrew F Shorr
    Pulmonary, Critical Care, and Sleep Medicine Service, Walter Reed Army Medical Center, Washington, DC 20307, USA
    JAMA 292:2997-3005. 2004
    ..Acute eosinophilic pneumonia (AEP) is a rare disease of unknown etiology characterized by respiratory failure, radiographic infiltrates, and eosinophilic infiltration of the lung...
  77. ncbi OX40 ligation on activated T cells enhances the control of Cryptococcus neoformans and reduces pulmonary eosinophilia
    Ian R Humphreys
    Center for Molecular Microbiology and Infection, Department of Biochemistry, Imperial College of Science, Technology and Medicine, London, United Kingdom
    J Immunol 170:6125-32. 2003
    b>Pulmonary eosinophilia induced in C57BL/6 mice after Cryptococcus neoformans infection is driven by CD4(+) Th2 cells. The immunological mechanisms that protect against eosinophilia are not fully understood...
  78. ncbi A critical role for Pin1 in allergic pulmonary eosinophilia in rats
    Stephane Esnault
    Waisman Center for Developmental Disabilities, Department of Pathology and Laboratory Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI 53705, USA
    J Allergy Clin Immunol 120:1082-8. 2007
    ..We recently showed that in vitro Pin1 regulated eosinophil production of and response to GM-CSF...
  79. ncbi Eosinophilic lung diseases: a clinical, radiologic, and pathologic overview
    Yeon Joo Jeong
    Department of Diagnostic Radiology, Pusan National University Hospital, Pusan National University School of Medicine and Medical Research Institute, 1 10, Ami dong, Seo Gu, Pusan 602 739, Korea
    Radiographics 27:617-37; discussion 637-9. 2007
    ..They are classified as eosinophilic lung diseases of unknown cause (simple pulmonary eosinophilia [SPE], acute eosinophilic pneumonia [AEP], chronic eosinophilic pneumonia [CEP], idiopathic ..
  80. ncbi Chronic eosinophilic pneumonia after radiation therapy for breast cancer
    V Cottin
    Service de Pneumologie, Hopital Cardiovasculaire et Pneumologique Louis Pradel, Universite Claude Bernard, Lyon, France
    Eur Respir J 23:9-13. 2004
    ....
  81. ncbi Acute eosinophilic pneumonia
    James Allen
    Department of Clinical Internal Medicine, Division of Pulmonary and Critical Care Medicine, Ohio State University, Columbus, Ohio 43205, USA
    Semin Respir Crit Care Med 27:142-7. 2006
    ..In some patients, acute eosinophilic pneumonia may be caused by drugs, tobacco smoke, or other inhaled substances; however, in the majority of patients, the condition is idiopathic...
  82. ncbi In vivo IL-10 gene delivery suppresses airway eosinophilia and hyperreactivity by down-regulating APC functions and migration without impairing the antigen-specific systemic immune response in a mouse model of allergic airway inflammation
    Kazuyuki Nakagome
    Department of Allergy and Rheumatology, Graduate School of Medicine, University of Tokyo, Japan
    J Immunol 174:6955-66. 2005
    ..Therefore, if delivered selectively, IL-10 could site specifically suppress the Ag-specific immune response without affecting systemic immune responses...
  83. ncbi Antigen-induced airway hyperresponsiveness, pulmonary eosinophilia, and chemokine expression in B cell-deficient mice
    J A MacLean
    Clinical Immunology and Allergy Unit and Infectious Disease Unit, Department of Medicine, Massachusetts General Hospital, Boston 02114, USA
    Am J Respir Cell Mol Biol 20:379-87. 1999
    ..pulmonary inflammation share many features with human asthma, including the development of antigen-induced pulmonary eosinophilia, airway hyperresponsiveness, antigen-specific cellular and antibody responses, the elaboration of Th2 ..
  84. pmc Priming with a secreted form of the fusion protein of respiratory syncytial virus (RSV) promotes interleukin-4 (IL-4) and IL-5 production but not pulmonary eosinophilia following RSV challenge
    G P Bembridge
    Institute for Animal Health, Compton, Newbury RG20 7NN, United Kingdom
    J Virol 73:10086-94. 1999
    ..However, this change alone does not appear sufficient to induce vaccine-augmented disease in the face of active CD8(+) CTL populations...
  85. ncbi Gq signaling is required for allergen-induced pulmonary eosinophilia
    Michael T Borchers
    Division of Pulmonary Medicine, Mayo Clinic, Scottsdale AZ 85259, USA
    J Immunol 168:3543-9. 2002
    ..leukocytes in the lung elicits expression of GM-CSF, which, in turn, is required for allergen-induced pulmonary eosinophilia, identifying a novel pathway of eosinophil-associated effector functions leading to pulmonary pathology in ..
  86. ncbi Innate and cognate mechanisms of pulmonary eosinophilia in helminth infection
    Fiona J Culley
    Leukocyte Biology Section, Biomedical Sciences Division, Imperial College Faculty of Medicine, London, GB
    Eur J Immunol 32:1376-85. 2002
    Passage of helminth larvae through the lungs can cause pulmonary eosinophilia that may have evolved as a means of parasite attrition...
  87. pmc Beta 2-microglobulin-dependent T cells are dispensable for allergen-induced T helper 2 responses
    Y Zhang
    Department of Pediatrics, University of Washington, Seattle 98195, USA
    J Exp Med 184:1507-12. 1996
    ..OVA-treated beta 2m -/- mice had circulating levels of total and OVA-specific IgE, pulmonary eosinophilia, and expression of IL-4, IL-5, and IL-13 mRNA in bronchial lymph node tissue similar to that of OVA-..
  88. ncbi Identification of R146225 as a novel, orally active inhibitor of interleukin-5 biosynthesis
    J Van Wauwe
    Janssen Research Foundation, Beerse, Belgium
    J Pharmacol Exp Ther 295:655-61. 2000
    ..azauracil derivative, as a potent, orally active inhibitor of IL-5 biosynthesis, capable of reducing pulmonary eosinophilia in mice...
  89. ncbi Lung tissue eosinophils may be cleared through luminal entry rather than apoptosis: effects of steroid treatment
    L Uller
    Department of Physiological Sciences, University Hospital, Lund, Sweden
    Am J Respir Crit Care Med 164:1948-56. 2001
    ....
  90. ncbi Critical role for IL-13 in the development of allergen-induced airway hyperreactivity
    D M Walter
    Division of Immunology and Allergy, Department of Pediatrics, Stanford University, Stanford, CA 94305, USA
    J Immunol 167:4668-75. 2001
    ..Therefore, treatment of human asthma with antagonists of IL-13 may be very effective...
  91. ncbi Acute eosinophilic pneumonia in a New York City firefighter exposed to World Trade Center dust
    William N Rom
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, New York University School of Medicine, New York 10016, USA
    Am J Respir Crit Care Med 166:797-800. 2002
    ..Acute eosinophilic pneumonia is a rare consequence of acute high dust exposure. World Trade Center dust consists of large particle-size silicates, but fly ash and asbestos fibers may be found in bronchoalveolar lavage cells...
  92. ncbi The role of CD23 on allergen-induced IgE levels, pulmonary eosinophilia and bronchial hyperresponsiveness in mice
    Y Riffo-Vasquez
    The Sackler Institute of Pulmonary Pharmacology, Division of Pharmacology and Therapeutics, GKT School of Biomedical Sciences, King s College London, UK
    Clin Exp Allergy 30:728-38. 2000
    ....
  93. ncbi CD4 T-helper cells engineered to produce IL-10 prevent allergen-induced airway hyperreactivity and inflammation
    Jae Won Oh
    Division of Immunology and Allergy, Department of Pediatrics, Stanford University, CA 94305, USA
    J Allergy Clin Immunol 110:460-8. 2002
    ..T(H)2 cells play a critical role in the pathogenesis of asthma, but the precise immunologic mechanisms that inhibit T(H)2 cell function in vivo are not well understood...
  94. ncbi Chronic eosinophilic pneumonia due to visceral larva migrans
    Koji Inoue
    Department of Internal Medicine, National Kinki Chuo Hospital for Chest Diseases, Sakai, Osaka
    Intern Med 41:478-82. 2002
    ....
  95. ncbi Ectopic expression of IL-5 identifies an additional CD4(+) T cell mechanism of airway eosinophil recruitment
    Jeffrey R Crosby
    Division of Hematology Oncology, Department of Biochemistry and Molecular Biology, Mayo Clinic Scottsdale, Scottsdale, Arizona 85259, USA
    Am J Physiol Lung Cell Mol Physiol 282:L99-108. 2002
    ..1726 CD4(-/-) mice, suggesting that eosinophil trafficking during allergic inflammatory responses is a consequence of a CD4(+) cell-mediated event(s) in addition to IL-5 expression and the establishment of a pulmonary chemokine gradient...
  96. ncbi CC chemokine receptor-2 is not essential for the development of antigen-induced pulmonary eosinophilia and airway hyperresponsiveness
    J A MacLean
    Center for Immunology and Inflammatory Disease, Division of Rheumatology, Allergy, and Immunology, Massachusetts General Hospital, Pulmonary and Critical Care Divisions, Brigham and Women s Hospital, Boston, MA 02114, USA
    J Immunol 165:6568-75. 2000
    ..repeated airway challenges with Ag in sensitized mice, the development of Th2 responses (elevated IgE, pulmonary eosinophilia, and lung cytokine levels of IL-4 and IL5) and the development of airway hyper-responsiveness are not ..
  97. ncbi Antieosinophilic activity of simendans
    Hannu Kankaanranta
    The Immunopharmacology Research Group, Medical School, University of Tampere, Finland
    J Pharmacol Exp Ther 323:31-8. 2007
    ..The aim of the present study was to evaluate whether simendans reduce pulmonary eosinophilia and regulate eosinophil apoptosis...
  98. pmc A novel transcription factor inhibitor, SP100030, inhibits cytokine gene expression, but not airway eosinophilia or hyperresponsiveness in sensitized and allergen-exposed rat
    T J Huang
    Thoracic Medicine, Chang Gung Memorial Hospital, Keelung Branch, Taiwan, Republic of China
    Br J Pharmacol 134:1029-36. 2001
    ..5. The joint AP-1 and NF-kappa B inhibitor, SP100030, selectively inhibits CD8(+) T-cells, and mRNA expression of both Th1 and Th2 cytokines in vivo, but does not inhibit allergen-induced airway eosinophilia and BHR...
  99. ncbi Inhaled p38alpha mitogen-activated protein kinase antisense oligonucleotide attenuates asthma in mice
    Wei Duan
    Department of Pharmacology, Faculty of Medicine, National University of Singapore, MD2, 18 Medical Drive, Singapore 117597
    Am J Respir Crit Care Med 171:571-8. 2005
    ..Nose-only aerosol exposure of mice verified the p38alpha-ASO-induced inhibition of OVA-induced pulmonary eosinophilia, mucus hypersecretion, and airway hyperresponsiveness...
  100. ncbi Eosinophils promote allergic disease of the lung by regulating CD4(+) Th2 lymphocyte function
    J R MacKenzie
    Division of Biochemistry and Molecular Biology, John Curtin School of Medical Research, Australian National University, Canberra, Australia
    J Immunol 167:3146-55. 2001
    ..This investigation highlights the potential of eosinophils to not only act as terminal effector cells but also to actively modulate allergic inflammation by amplifying Th2 cell responses...
  101. ncbi Resolution of airway inflammation following ovalbumin inhalation: comparison of ISS DNA and corticosteroids
    Reid K Ikeda
    Department of Medicine, University of California San Diego, La Jolla, CA 92093 0635, USA
    Am J Respir Cell Mol Biol 28:655-63. 2003
    ..The combination of the shared and distinct anti-inflammatory pathways may account for the additive effect of ISS and corticosteroids on inhibiting AHR...

Research Grants41

  1. ROLE OF MUC1 IN THE GENESIS OF ALLERGIC ASTHMA
    Kwang Chul Kim; Fiscal Year: 2010
    ..Interestingly, our recent preliminary studies suggest that Muc1-null mice fail to exhibit pulmonary eosinophilia and goblet cell hyperplasia as seen in wild type littermates in an ovalbumin (OVA)-induced asthma model...
  2. A Novel Model of, and Pre-clinical Therapy for, Scleroderma Lung Disease
    Sergei P Atamas; Fiscal Year: 2012
    ..For example, while causing the mentioned changes resembling of human SLD, mIL-442 does not induce pulmonary eosinophilia or goblet cell hyperplasia (the features that are common in asthma but not in SLD, and that are readily ..
  3. A Mucosal RSV Vaccine
    Kejian Yang; Fiscal Year: 2013
    ..to suffer from enhanced disease severity and even death upon subsequent RSV infection concomitant with pulmonary eosinophilia. Severe lung inflammatory responses characterized by a skewed CD4+ T-cell response (in the absence of ..
  4. PARTICIPATION OF PARP-1 IN THE PATHOGENESIS OF ASTHMA
    Hamid Boulares; Fiscal Year: 2013
    ..Asthma is, in part, a Th2 lymphocyte-mediated inflammatory airway disease characterized by pulmonary eosinophilia and airway hyper-responsiveness (AHR)...
  5. Mouse Models of Eosinophil-Associated Lung Dysfunction
    Nancy A Lee; Fiscal Year: 2013
    ..we have demonstrated that all of the pathologies in I5/hE2 mice are absolutely dependent on the induced pulmonary eosinophilia. This proposal capitalizes on the availability of the I5/hE2 transgenic model as well as our unique ..
  6. ST6Gal-1 Sialyltransferase in Allergic Airway Inflammation
    Joseph T Y Lau; Fiscal Year: 2010
    ..Expression of recombinant ST6Gal-1 in vivo can attenuate the pulmonary eosinophilia, suggesting a therapeutic potential for ST6Gal-1...
  7. Eosinophil-Airway Epithelial Fas-FasL Interactions
    Kimm Hamann; Fiscal Year: 2004
    ..infiltrates such as eosinophils, and that in asthma this function is impaired contributing to persistent pulmonary eosinophilia. These studies will address molecular mechanisms which regulate the functional expression of FasL on ..
  8. CYTOKINE REGULATION OF A MOUSE MODEL OF ASTHMA
    Fred Finkelman; Fiscal Year: 2003
    ..eosinophils to the lungs, the mechanism by which TGF-alpha acts synergistically with IL-4 to induce pulmonary eosinophilia and the mechanism by which IL-12 inhibits IL-4 induced pulmonary eosinophilia...
  9. MOLECULAR BIOLOGY OF HUMAN FILARIAL PARASITES
    THIRUCHANDURAI RAJAN; Fiscal Year: 1990
    ..We have used a serum from a patient suffering from Tropical Pulmonary Eosinophilia (TPE) to isolate several reactive gt-11 clones and have sequenced the inserts in two of them...
  10. Eosinophil Regulation of Pulmonary IL-13 Levels
    Elizabeth Jacobsen; Fiscal Year: 2007
    ..correlation between the pathologies associated with allergic respiratory inflammation and the accompanying pulmonary eosinophilia the specific role(s) of eosinophils and/or eosinophil effector functions (EEFs) in asthma are poorly ..
  11. Early Immune Events in Childhood Asthma
    Lisa Miller; Fiscal Year: 2009
    ..Thus, our central hypothesis is that pulmonary eosinophilia is a critical first step in the initiation of allergic airways disease during postnatal development;..
  12. T CELLS & CHEMOKINES IN ALLERGIC PULMONARY INFLAMMATION
    James Maclean; Fiscal Year: 2000
    ..3) To determine the effect of neutralizing eotaxin in vivo, on antigen-induced pulmonary eosinophilia and airways hyperresponsiveness in a murine model of antigen-induced pulmonary eosinophilia...
  13. Oxidative stress in asthma initiation
    Sanjiv Sur; Fiscal Year: 2010
    ..Future studies of POPAC may identify novel therapeutic approaches in asthma. ..
  14. Towards a better understanding of work-aggravated asthma
    Catherine Lemiere; Fiscal Year: 2009
    ..The occurrence of asthma exacerbations will be recorded. The economic impact of WAA will be assessed in terms of work disability and use of health resources and compared with OA and asthma without OA not WAA. ..
  15. Asthma Clinical Research Network-Washington University
    Mario Castro; Fiscal Year: 2007
    ..We propose that it is only through such a collaboration that important questions regarding current and novel therapies and management of asthma can be answered. ..
  16. Role of Oxylipins in Cryptococcal Pathogenesis
    GARY HUFFNAGLE; Fiscal Year: 2008
    ..production; (3) to determine the role of the fungal oxylipin CnPGEx in cryptococcal biology and pathogenesis; (4) to determine the role of host PGE2 and other prostaglandins in cryptococcal biology and host immunity ..
  17. T CELL CONTROL OF AIRWAY MUCUS PRODUCTION
    Lauren Cohn; Fiscal Year: 2009
    ..AIM II. Determine the mechanism of IFN-g inhibition of eosinophilia and its relationship to the reciprocal induction of neutrophilia. AIM III. Determine how IFN-g regulates the number of Th2 cells in the respiratory tract. ..
  18. Role of Fungal Microflora in Mucosal Tolerance/Immunity
    GARY HUFFNAGLE; Fiscal Year: 2009
    ..These studies will provide the basic science foundation for future studies in humans for understanding how and why manipulation of the microflora (by diet or probiotics) can alter or prevent allergies. ..
  19. Monoclonal antibodies to inhibit Aspergillus germination
    MARTA L FELDMESSER; Fiscal Year: 2010
    ..It is anticipated that this study will identify fungal molecules important for germination and begin to define their interaction with host immune responses. ..
  20. FLT3-LIGAND, IMMUNOMODULATION AND THERAPY IN ASTHMA
    DEVENDRA AGRAWAL; Fiscal Year: 2008
    ..The long-term goal of this study is to better define the potential mechanisms of action of FL to prevent and reverse allergic airway inflammation and associated changes in pulmonary function. ..
  21. TGF-BETA, CHLORIDE CHANNELS AND APOPTOSIS OF AIRWAY EPITHELIAL CELLS
    Devendra K Agrawal; Fiscal Year: 2010
    ..Such investigations would provide unique insights to the pathophysiologic process of chronic asthma and the means to prevent or reverse the disease. ..
  22. Aquaporin 5 (AQP5) in Lung Fluid Homeostasis
    CARISSA KRANE; Fiscal Year: 2004
    ..This combinatorial approach will provide valuable information for the identification of new mechanistic pathways critical for the development of novel drug targets for the treatment of asthma. ..
  23. Monoclonal antibodies for invasive aspergillosis
    Marta Feldmesser; Fiscal Year: 2003
    ..To determine the biological activity of MAbs generated in Aim 2 in murine models of invasive aspergillosis. It is anticipated that this study will identify important targets for further investigation. ..
  24. INFLAMMATION & CORTICOSTEROID RESPONSES IN SEVERE ASTHMA
    KIAN CHUNG; Fiscal Year: 2005
    ..The molecular mechanisms underlying loss of CR will be examined. These studies should lead to more effective therapies for chronic severe asthma. ..
  25. Biomarkers in sputum in COPD
    David Broide; Fiscal Year: 2005
    ..abstract_text> ..
  26. RSV AND ASTHMA
    David Broide; Fiscal Year: 2003
    ..Overall these studies will contribute to our understanding of the mechanism of eosinophilic inflammation during RSV infection and suggest candidate vaccine strategies to inhibit RSV infection and airway inflammation. ..
  27. GENETIC, BIOLOGIC, & IMMUNOLOGIC DETERMINANTS OF ASTHMA
    Mario Castro; Fiscal Year: 2006
    ..abstract_text> ..
  28. Aspergillosis: Engineering Antibody for Diagnosis
    Marta Feldmesser; Fiscal Year: 2006
    ..The availability of reagents that have potential to improve both sensitivity and specificity of galactomannan detection would be a significant advance. ..
  29. MODULATION OF TH1/TH2 RESPONSES BY INNATE IMMUNITY
    GARY HUFFNAGLE; Fiscal Year: 2004
    ..One of the potential implications of these studies is that therapies inhibiting melanin biosynthesis or activity may also have an adjuvant effect and promote the development of protective Th1 immunity to C. neoformans. ..
  30. CHEMOKINE RECEPTORS IN IMMUNITY TO C NEOFORMANS
    GARY HUFFNAGLE; Fiscal Year: 2003
    ..neoformans infection; (5) To determine the role of MCP-1 and CCR2 in the development of a Th2 response to C. neoformans. ..
  31. Asthma Induction by Dendritic Cells and Th2 Cells
    Sun Sang Sung; Fiscal Year: 2007
    ..The results may provide additional therapeutic strategies in asthma by the interference of SLC functions and by regulating the migration of DC, Th1, and IFN-gamma-producing CD8+ T cells. ..
  32. Role of the Leukotriene B4 Receptors in Asthma
    BENJAMIN MEDOFF; Fiscal Year: 2003
    ..Repeat experiments in the presence of a BLTR2 antagonist will also allow characterization of the role of this receptor in asthma. ..
  33. New York University School of Medicine CTSA Planning Grant
    William Rom; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  34. Eosinophil Trafficking
    David Broide; Fiscal Year: 2005
    ..Overall, these studies should improve our understanding of the molecular mechanism of eosinophil recruitment in vivo and its effect on airway structure and function. ..
  35. ENDOTHELIUM--SIGNALING FROM MAST CELLS TO EOSINOPHILS
    David Broide; Fiscal Year: 2002
    ....
  36. Airway Remodeling in Severe Asthma
    Mario Castro; Fiscal Year: 2005
    ..The identification of the potential variables associated with remodeling and severe asthma will help identify individuals at risk who would benefit from specific targeted therapy. ..
  37. Chemokines in lung transplantation
    BENJAMIN MEDOFF; Fiscal Year: 2007
    ..abstract_text> ..
  38. The Reliability of the Placebo Effect in Asthma
    Michael Wechsler; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  39. Polymorphisms of Neural NOS and the Asthma Phenotype
    Michael Wechsler; Fiscal Year: 2005
    ....
  40. HOST RESPONSE TO TB AND AIDS
    William Rom; Fiscal Year: 2006
    ..This study is critical in developing efficacious treatment strategies for TB and demonstrating that rIFN-gamma ameliorates the lung fibrosis and destruction in advanced TB. ..
  41. IMMUNE RESPONSE IN THE LUNG TO TB PROTEINS IN AIDS
    William Rom; Fiscal Year: 2002
    ..tb. proteins in PBMCs and BAL. This proposal will provide critical information on memory immunity in the lung when humans are infected/exposed to M. tb. and how this "protective" immune response to TB may be perturbated in AIDS. ..