pulmonary embolism

Summary

Summary: Embolism in the pulmonary artery or one of its branches.

Top Publications

  1. ncbi Guidelines on the diagnosis and management of acute pulmonary embolism: the Task Force for the Diagnosis and Management of Acute Pulmonary Embolism of the European Society of Cardiology (ESC)
    Adam Torbicki
    Department of Chest Medicine, Institute for Tuberculosis and Lung Diseases, Warsaw, Poland
    Eur Heart J 29:2276-315. 2008
  2. ncbi Multidetector computed tomography for acute pulmonary embolism
    Paul D Stein
    Department of Research, St Joseph Mercy Oakland Hospital, Pontiac, Mich, USA
    N Engl J Med 354:2317-27. 2006
  3. ncbi Chronic thromboembolic pulmonary hypertension
    Marius M Hoeper
    Department of Respiratory Medicine, Hannover Medical School, 30623 Hannover, Germany
    Circulation 113:2011-20. 2006
  4. ncbi Oral, direct Factor Xa inhibition with BAY 59-7939 for the prevention of venous thromboembolism after total hip replacement
    B I Eriksson
    Sahlgrenska University HospitalOstra, Gothenburg, Sweden
    J Thromb Haemost 4:121-8. 2006
  5. ncbi Venous thromboembolism: disease burden, outcomes and risk factors
    J A Heit
    Division of Cardiovascular Diseases Section of Vascular Diseases, Department of Internal Medicine, Mayo Clinic and Mayo Foundation, Rochester, MN 55905, USA
    J Thromb Haemost 3:1611-7. 2005
  6. ncbi The epidemiology of venous thromboembolism
    Richard H White
    University of California, Davis, Sacramento, California, USA
    Circulation 107:I4-8. 2003
  7. ncbi Antithrombotic therapy for venous thromboembolic disease: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition)
    Clive Kearon
    Hamilton Health Sciences, Henderson Division, 711 Concession Street, Hamilton, Ontario, Canada
    Chest 133:454S-545S. 2008
  8. ncbi Pulmonary embolism and deep vein thrombosis
    Samuel Z Goldhaber
    Brigham and Women s Hospital, Department of Medicine, Harvard Medical School, Cardiovascular Division, Boston, MA 02115, USA
    Lancet 379:1835-46. 2012
  9. ncbi Rivaroxaban versus enoxaparin for thromboprophylaxis after hip arthroplasty
    Bengt I Eriksson
    Sahlgrenska University Hospital Ostra, Gothenburg, Sweden
    N Engl J Med 358:2765-75. 2008
  10. ncbi Risk factors for deep vein thrombosis and pulmonary embolism: a population-based case-control study
    J A Heit
    Division of Cardiovascular Diseases, Mayo Clinic and Mayo Foundation, Rochester, Minn 55905, USA
    Arch Intern Med 160:809-15. 2000

Research Grants

  1. Right ventricular contractile dysfunction after pressure overload
    CLIFFORD RUSSELL GREYSON; Fiscal Year: 2013
  2. MOLECULAR BIOLOGY OF HUMAN COAGULATION FACTOR V
    Thomas Ortel; Fiscal Year: 2010
  3. Dual Direct Inhibitors of Thrombin and Factor Xa
    UMESH RAMANLAL DESAI; Fiscal Year: 2012
  4. Heme Oxygenase-1 in Lung Ischemia-Reperfusion Injury
    Patty J Lee; Fiscal Year: 2012
  5. PET Imaging of Thrombus
    PETER D CARAVAN; Fiscal Year: 2013
  6. Proteolytic Pathways in Thrombus Resolution
    Toni M Antalis; Fiscal Year: 2013
  7. Randomized trial of inhaled nitric oxide to treat acute pulmonary embolism
    Jeffrey A Kline; Fiscal Year: 2013
  8. Reasons for Racial Disparities in Venous Thromboembolism
    NEIL ADRIAN ZAKAI; Fiscal Year: 2010
  9. Structural and Biochemical Basis of the Vitamin K cycle
    Weikai Li; Fiscal Year: 2013
  10. High throughput assay for fibrin-binding probes
    PETER D CARAVAN; Fiscal Year: 2013

Detail Information

Publications392 found, 100 shown here

  1. ncbi Guidelines on the diagnosis and management of acute pulmonary embolism: the Task Force for the Diagnosis and Management of Acute Pulmonary Embolism of the European Society of Cardiology (ESC)
    Adam Torbicki
    Department of Chest Medicine, Institute for Tuberculosis and Lung Diseases, Warsaw, Poland
    Eur Heart J 29:2276-315. 2008
    ..With the exception of severe air and fat embolism, the haemodynamic consequences of non-thrombotic emboli are usually mild. Treatment is mostly supportive but may differ according to the type of embolic material and clinical severity...
  2. ncbi Multidetector computed tomography for acute pulmonary embolism
    Paul D Stein
    Department of Research, St Joseph Mercy Oakland Hospital, Pontiac, Mich, USA
    N Engl J Med 354:2317-27. 2006
    The accuracy of multidetector computed tomographic angiography (CTA) for the diagnosis of acute pulmonary embolism has not been determined conclusively.
  3. ncbi Chronic thromboembolic pulmonary hypertension
    Marius M Hoeper
    Department of Respiratory Medicine, Hannover Medical School, 30623 Hannover, Germany
    Circulation 113:2011-20. 2006
  4. ncbi Oral, direct Factor Xa inhibition with BAY 59-7939 for the prevention of venous thromboembolism after total hip replacement
    B I Eriksson
    Sahlgrenska University HospitalOstra, Gothenburg, Sweden
    J Thromb Haemost 4:121-8. 2006
    ..Joint replacement surgery is an appropriate model for dose-ranging studies investigating new anticoagulants...
  5. ncbi Venous thromboembolism: disease burden, outcomes and risk factors
    J A Heit
    Division of Cardiovascular Diseases Section of Vascular Diseases, Department of Internal Medicine, Mayo Clinic and Mayo Foundation, Rochester, MN 55905, USA
    J Thromb Haemost 3:1611-7. 2005
    ..incidence), outcomes (survival, recurrence and complications) and risk factors for deep vein thrombosis and pulmonary embolism occurring in the community...
  6. ncbi The epidemiology of venous thromboembolism
    Richard H White
    University of California, Davis, Sacramento, California, USA
    Circulation 107:I4-8. 2003
    ..5%) per 100,000 persons at age 80 years. Approximately one third of patients with symptomatic VTE manifest pulmonary embolism (PE), whereas two thirds manifest deep vein thrombosis (DVT) alone...
  7. ncbi Antithrombotic therapy for venous thromboembolic disease: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition)
    Clive Kearon
    Hamilton Health Sciences, Henderson Division, 711 Concession Street, Hamilton, Ontario, Canada
    Chest 133:454S-545S. 2008
    ..in this chapter are the following: for patients with objectively confirmed deep vein thrombosis (DVT) or pulmonary embolism (PE), we recommend anticoagulant therapy with subcutaneous (SC) low-molecular-weight heparin (LMWH), ..
  8. ncbi Pulmonary embolism and deep vein thrombosis
    Samuel Z Goldhaber
    Brigham and Women s Hospital, Department of Medicine, Harvard Medical School, Cardiovascular Division, Boston, MA 02115, USA
    Lancet 379:1835-46. 2012
    b>Pulmonary embolism is the third most common cause of death from cardiovascular disease after heart attack and stroke...
  9. ncbi Rivaroxaban versus enoxaparin for thromboprophylaxis after hip arthroplasty
    Bengt I Eriksson
    Sahlgrenska University Hospital Ostra, Gothenburg, Sweden
    N Engl J Med 358:2765-75. 2008
    ..This phase 3 trial compared the efficacy and safety of rivaroxaban, an oral direct inhibitor of factor Xa, with those of enoxaparin for extended thromboprophylaxis in patients undergoing total hip arthroplasty...
  10. ncbi Risk factors for deep vein thrombosis and pulmonary embolism: a population-based case-control study
    J A Heit
    Division of Cardiovascular Diseases, Mayo Clinic and Mayo Foundation, Rochester, Minn 55905, USA
    Arch Intern Med 160:809-15. 2000
    ..Reported risk factors for venous thromboembolism (VTE) vary widely, and the magnitude and independence of each are uncertain...
  11. ncbi Simplification of the pulmonary embolism severity index for prognostication in patients with acute symptomatic pulmonary embolism
    David Jimenez
    Respiratory Department, Hospital Ramón y Cajal and Alcalá de Henares University, 28034 Madrid, Spain
    Arch Intern Med 170:1383-9. 2010
    The Pulmonary Embolism Severity Index (PESI) estimates the risk of 30-day mortality in patients with acute pulmonary embolism (PE). We constructed a simplified version of the PESI.
  12. ncbi Rivaroxaban versus enoxaparin for thromboprophylaxis after total knee arthroplasty
    Michael R Lassen
    Nordsjaellands Hospital, Hørsholm, Denmark
    N Engl J Med 358:2776-86. 2008
    ..We investigated the efficacy of rivaroxaban, an orally active direct factor Xa inhibitor, in preventing venous thrombosis after total knee arthroplasty...
  13. ncbi Venous thromboembolism (VTE) in Europe. The number of VTE events and associated morbidity and mortality
    Alexander T Cohen
    Vascular Medicine, Department of Surgery, King s College Hospital, London, SE5 9RS, UK
    Thromb Haemost 98:756-64. 2007
    ..EU countries was 465,715 (404,664-538,189) cases of deep-vein thrombosis, 295,982 (242,450-360,363) cases of pulmonary embolism (PE), and 370,012 (300,193-483,108) VTE-related deaths...
  14. ncbi Prognostic value of echocardiographically assessed right ventricular dysfunction in patients with pulmonary embolism
    Marije Ten Wolde
    Department of Vascular Medicine, Academic Medical Center, Amsterdam, The Netherlands
    Arch Intern Med 164:1685-9. 2004
    ..dysfunction is increasingly used to guide more aggressive therapy in hemodynamically stable patients with acute pulmonary embolism (PE). However, the prognostic value of right ventricular dysfunction in these patients is still unclear.
  15. ncbi Highly sensitive troponin T assay in normotensive patients with acute pulmonary embolism
    Mareike Lankeit
    Department of Cardiology and Pulmonology, University of Gottingen, 37099 Gottingen, Germany
    Eur Heart J 31:1836-44. 2010
    To assess the role of cardiac troponin T (cTnT) levels on admission using a new, highly sensitive assay (hsTnT) in the risk assessment of normotensive patients with acute pulmonary embolism (PE).
  16. ncbi Prevalence of pulmonary embolism in acute exacerbations of COPD: a systematic review and metaanalysis
    Jacques Rizkallah
    Department of Medicine, Respiratory Division, University of British Columbia, Heart and Lung Center, James Hogg iCAPTURE Center for Cardiovascular and Pulmonary Research at St Paul s Hospital, 1081 Burrard Street, Vancouver, BC, Canada
    Chest 135:786-93. 2009
    Nearly 30% of all exacerbations of COPD do not have a clear etiology. Although pulmonary embolism (PE) can exacerbate respiratory symptoms such as dyspnea and chest pain, and COPD patients are at a high risk for PE due to a variety of ..
  17. pmc Patient outcomes after deep vein thrombosis and pulmonary embolism: the Worcester Venous Thromboembolism Study
    Frederick A Spencer
    Department of Medicine, McMaster University, Faculty of Health Sciences and Blood Institute, Hamilton, ON, Canada
    Arch Intern Med 168:425-30. 2008
    Despite advances in the management of deep vein thrombosis (DVT) and pulmonary embolism (PE), relatively few contemporary data describe and compare outcomes in patients with these common conditions from a more generalizable community-..
  18. doi Acute pulmonary embolism
    Victor F Tapson
    Division of Pulmonary and Critical Care Medicine, Duke University Medical Center, Durham, NC 27710, USA
    N Engl J Med 358:1037-52. 2008
  19. ncbi Predictors of survival after deep vein thrombosis and pulmonary embolism: a population-based, cohort study
    J A Heit
    Department of Medicine, Mayo Clinic and Mayo Foundation, Rochester, Minn 55905, USA
    Arch Intern Med 159:445-53. 1999
    ....
  20. ncbi Malignancies, prothrombotic mutations, and the risk of venous thrombosis
    Jeanet W Blom
    Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands
    JAMA 293:715-22. 2005
    ..Venous thrombosis is a common complication in patients with cancer, leading to additional morbidity and compromising quality of life...
  21. ncbi Prognostic value of troponins in acute pulmonary embolism: a meta-analysis
    Cecilia Becattini
    Medicina Interna e Cardiovascolare, Dipartimento di Medicina Interna, University of Perugia, Via G Dottori 1, 06129 Perugia, Italy
    Circulation 116:427-33. 2007
    Whether elevated serum troponin levels identify patients with acute pulmonary embolism at high risk of short-term mortality or adverse outcome is undefined.
  22. ncbi Evaluation of D-dimer in the diagnosis of suspected deep-vein thrombosis
    Philip S Wells
    Department of Medicine, Ottawa Hospital, University of Ottawa, Ottawa, Ont, Canada
    N Engl J Med 349:1227-35. 2003
    ....
  23. ncbi Usefulness of admission red cell distribution width as a predictor of early mortality in patients with acute pulmonary embolism
    Ali Zorlu
    Department of Cardiology, Cumhuriyet University Medical School, Sivas, Turkey
    Am J Cardiol 109:128-34. 2012
    ..However, its prognostic significance in acute pulmonary embolism (PE) is unknown...
  24. ncbi Prognostic value of right ventricular dysfunction in patients with haemodynamically stable pulmonary embolism: a systematic review
    Olivier Sanchez
    Division of Respiratory and Intensive Care Medicine, Georges Pompidou European Hospital, 75015 Paris, France
    Eur Heart J 29:1569-77. 2008
    ..assessed by echocardiography or spiral computed tomography (CT), or by increased levels of cardiac biomarkers [troponin, brain natriuretic peptide (BNP) and pro-BNP] in patients with haemodynamically stable pulmonary embolism (PE).
  25. pmc Prognostic importance of hyponatremia in patients with acute pulmonary embolism
    Nathalie Scherz
    Division of General Internal Medicine, University of Lausanne, Lausanne, Switzerland
    Am J Respir Crit Care Med 182:1178-83. 2010
    Although associated with adverse outcomes in other cardiopulmonary conditions, the prognostic value of hyponatremia, a marker of neurohormonal activation, in patients with acute pulmonary embolism (PE) is unknown.
  26. ncbi Enoxaparin followed by once-weekly idrabiotaparinux versus enoxaparin plus warfarin for patients with acute symptomatic pulmonary embolism: a randomised, double-blind, double-dummy, non-inferiority trial
    Harry R Buller
    Department of Vascular Medicine, Academic Medical Centre, Amsterdam, Netherlands
    Lancet 379:123-9. 2012
    Treatment of pulmonary embolism with low-molecular-weight heparin and vitamin K antagonists, such as warfarin, is not ideal...
  27. ncbi Outpatient versus inpatient treatment for patients with acute pulmonary embolism: an international, open-label, randomised, non-inferiority trial
    Drahomir Aujesky
    Bern University Hospital, Switzerland
    Lancet 378:41-8. 2011
    Although practice guidelines recommend outpatient care for selected, haemodynamically stable patients with pulmonary embolism, most treatment is presently inpatient based...
  28. pmc Time trends in pulmonary embolism in the United States: evidence of overdiagnosis
    Renda Soylemez Wiener
    The Pulmonary Center, Boston University School of Medicine, Massachusetts 02118, USA
    Arch Intern Med 171:831-7. 2011
    Computed tomographic pulmonary angiography (CTPA) may improve detection of life-threatening pulmonary embolism (PE), but this sensitive test may have a downside: overdiagnosis and overtreatment (finding clinically unimportant emboli and ..
  29. ncbi Acute pulmonary embolism to the subsegmental level: diagnostic accuracy of three MRI techniques compared with 16-MDCT
    Alexander Kluge
    Department of Diagnostic Radiology, Kerckhoff Heart Center, Benekestrasse 2 8, Bad Nauheim, Germany 61231
    AJR Am J Roentgenol 187:W7-14. 2006
    The purpose of this study was to assess the individual and combined usefulness of MRI techniques in cases of acute pulmonary embolism and to compare the usefulness of these techniques with that of 16-MDCT.
  30. pmc Incidence and risk factors for fatal pulmonary embolism after major trauma: a nested cohort study
    K M Ho
    Department of Intensive Care Medicine, School of Population Health, University of Western Australia, Australia
    Br J Anaesth 105:596-602. 2010
    Venous thromboembolism is common after major trauma. Strategies to prevent fatal pulmonary embolism (PE) are widely utilized, but the incidence and risk factors for fatal PE are poorly understood.
  31. ncbi CT angiography of pulmonary arteries to detect pulmonary embolism: improvement of vascular enhancement with low kilovoltage settings
    Claudia Schueller-Weidekamm
    Department of Radiology, University Hospital of Vienna, Vienna, Austria
    Radiology 241:899-907. 2006
    ....
  32. ncbi Major pulmonary embolism: review of a pathophysiologic approach to the golden hour of hemodynamically significant pulmonary embolism
    Kenneth E Wood
    Department of Medicine, University of Wisconsin Hospitals and Clinics, Madison, WI 53792, USA
    Chest 121:877-905. 2002
    Major pulmonary embolism (PE) results whenever the combination of embolism size and underlying cardiopulmonary status interact to produce hemodynamic instability...
  33. pmc Derivation and validation of a prognostic model for pulmonary embolism
    Drahomir Aujesky
    Division of General Internal Medicine, Clinical Epidemiology Center, University of Lausanne, Lausanne, Switzerland
    Am J Respir Crit Care Med 172:1041-6. 2005
    An objective and simple prognostic model for patients with pulmonary embolism could be helpful in guiding initial intensity of treatment.
  34. ncbi Prospective multicenter evaluation of the pulmonary embolism rule-out criteria
    J A Kline
    Department of Emergency Medicine, Carolinas Medical Center, Charlotte, NC 28323 2861, USA
    J Thromb Haemost 6:772-80. 2008
    Over-investigation of low-risk patients with suspected pulmonary embolism (PE) represents a growing problem...
  35. ncbi Relative impact of risk factors for deep vein thrombosis and pulmonary embolism: a population-based study
    John A Heit
    Hematology Research, Stabile 660, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA
    Arch Intern Med 162:1245-8. 2002
    ..risk (defined as the percentage of all cases of a disease in a population that can be "attributed" to a risk factor) for deep vein thrombosis and pulmonary embolism associated with venous thromboembolism risk factors.
  36. ncbi Chronic dialysis patients have high risk for pulmonary embolism
    Daniel P Tveit
    Nephrology Service, Walter Reed Army Medical Center, Washington, DC 20307 5001, USA
    Am J Kidney Dis 39:1011-7. 2002
    b>Pulmonary embolism has been considered uncommon in chronic dialysis patients, but has not been adequately studied in a large population...
  37. ncbi Pulmonary embolism and pneumonia may be confounded after acute stroke and may co-exist
    James Kelly
    Elderly Care Department and Haematology Department, North Wing 9th Floor, St Thomas Hospital, Lambeth Palace Road, Lambeth, London SE1 7EH, UK
    Age Ageing 31:235-9. 2002
    b>Pulmonary embolism and pneumonia are prevalent complications after acute stroke that overlap significantly in their timing, risk factors and clinical features...
  38. ncbi Detection of pulmonary embolism using dual-energy computed tomography and correlation with cardiovascular measurements: a preliminary study
    Long Jiang Zhang
    Department of Medical Imaging, Jinling Hospital, Clinical School of Medical College, Nanjing University, Nanjing, Jiangsu Province, China
    Acta Radiol 50:892-901. 2009
    Detection of a suspected pulmonary embolism (PE) has been the focus of considerable research over the past few decades...
  39. ncbi Prospective validation of the Pulmonary Embolism Severity Index. A clinical prognostic model for pulmonary embolism
    Jacques Donzé
    Service de Medecine Interne, Centre Hospitalier Universitaire Vaudois, 1011 Lausanne, Switzerland
    Thromb Haemost 100:943-8. 2008
    Practice guidelines recommend outpatient care for selected patients with non-massive pulmonary embolism (PE), but fail to specify how these low-risk patients should be identified. Using data from U.S...
  40. ncbi Lung perfusion with dual-energy multidetector-row CT (MDCT): feasibility for the evaluation of acute pulmonary embolism in 117 consecutive patients
    Francois Pontana
    Department of Thoracic Imaging, Hospital Calmette, University Center of Lille, Boulevard Jules Leclercq, 59037 Lille Cedex, France
    Acad Radiol 15:1494-504. 2008
    To investigate the accuracy of dual-energy computed tomography in the depiction of perfusion defects in patients with acute pulmonary embolism (PE).
  41. ncbi Preadmission hyperglycemia is an independent risk factor for in-hospital symptomatic pulmonary embolism after major orthopedic surgery
    Boris Mraovic
    Department of Anesthesiology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    J Arthroplasty 25:64-70. 2010
    We investigate whether preadmission hyperglycemia is a risk factor for developing in-hospital symptomatic pulmonary embolism after major orthopedic surgery...
  42. ncbi The prevalence of clinically relevant incidental findings on chest computed tomographic angiograms ordered to diagnose pulmonary embolism
    William B Hall
    Division of Pulmonary and Critical Care Medicine, University of North Carolina at Chapel Hill, Campus Box 7020, 130 Mason Farm Rd, Chapel Hill, NC 27514
    Arch Intern Med 169:1961-5. 2009
    Chest computed tomographic angiograms (CTAs) are frequently ordered for evaluation of suspected pulmonary embolism (PE) in the emergency department, but non-PE findings are often noted...
  43. ncbi Risk of recurrent venous thromboembolism and mortality in patients with cancer incidentally diagnosed with pulmonary embolism: a comparison with symptomatic patients
    Paul L den Exter
    Leiden University Medical Center, Leiden, The Netherlands
    J Clin Oncol 29:2405-9. 2011
    The routine use of modern computed tomography scanners has led to an increased detection of incidental pulmonary embolism (PE), in particular in patients with cancer. The clinical relevance of these incidental findings is unknown.
  44. ncbi Prospective study of the incidence of contrast-induced nephropathy among patients evaluated for pulmonary embolism by contrast-enhanced computed tomography
    Alice M Mitchell
    Department of Emergency Medicine, Carolinas HealthCare System, Charlotte, NC, USA
    Acad Emerg Med 19:618-25. 2012
    ..CECT) of the pulmonary arteries (CTPA) has become the mainstay to evaluate patients with suspected pulmonary embolism (PE) and is one of the most common CECT imaging studies performed in the emergency department (ED)...
  45. ncbi Symptomatic in-hospital deep vein thrombosis and pulmonary embolism following hip and knee arthroplasty among patients receiving recommended prophylaxis: a systematic review
    Jean Marie Januel
    Institute of Social and Preventive Medicine, Lausanne University Hospital, Switzerland
    JAMA 307:294-303. 2012
    ..Symptomatic venous thromboembolism (VTE) after total or partial knee arthroplasty (TPKA) and after total or partial hip arthroplasty (TPHA) are proposed patient safety indicators, but its incidence prior to discharge is not defined...
  46. ncbi Diagnosis and management of isolated subsegmental pulmonary embolism: review and assessment of the options
    Paul D Stein
    Department of Research, St Mary Mercy Hospital, Livonia, MI 48154, USA
    Clin Appl Thromb Hemost 18:20-6. 2012
    We assessed the potential safety of withholding treatment of pulmonary embolism (PE) limited to subsegmental branches...
  47. ncbi Clinical presentation and outcome of venous thromboembolism in COPD
    L Bertoletti
    Groupe de Recherche sur la Thrombose, EA3065, Universite de Saint Etienne, 42000 Saint Etienne, France
    Eur Respir J 39:862-8. 2012
    ..The clinical presentation of VTE, namely pulmonary embolism (PE) or deep venous thrombosis (DVT), and the outcome at 3 months (death, recurrent VTE or bleeding) were ..
  48. ncbi Performance of 4 clinical decision rules in the diagnostic management of acute pulmonary embolism: a prospective cohort study
    Renee A Douma
    Academic Medical Center, Amsterdam, The Netherlands
    Ann Intern Med 154:709-18. 2011
    Several clinical decision rules (CDRs) are available to exclude acute pulmonary embolism (PE), but they have not been directly compared.
  49. ncbi Pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertension: pathophysiology
    M Humbert
    Univ Paris Sud, Faculte de Medecine, Kremlin Bicetre, 2AP HP, Centre National de Référence de l Hypertension Pulmonaire Sévère, Service de Pneumologie et Reanimation Respiratoire, Hopital Antoine Beclere, Clamart, France
    Eur Respir Rev 19:59-63. 2010
    ..Further research into these similarities is needed to assist the development of targeted pharmacological therapies for patients with inoperable CTEPH and patients who have persistent pulmonary hypertension after endarterectomy...
  50. ncbi The challenge of diagnosing pulmonary embolism in elderly patients: influence of age on commonly used diagnostic tests and strategies
    Marc Righini
    Division of Angiology and Hemostasis, Geneva University Hospital and Faculty of Medicine, Geneva, Switzerland
    J Am Geriatr Soc 53:1039-45. 2005
    b>Pulmonary embolism (PE) is a potentially fatal disease if left untreated...
  51. ncbi ANP, BNP and D-dimer predict right ventricular dysfunction in patients with acute pulmonary embolism
    Henrik Gutte
    Department of Clinical Physiology, Nuclear Medicine and PET, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark
    Clin Physiol Funct Imaging 30:466-72. 2010
    ..ventricular dysfunction (RVD) using plasma concentration of D-dimer, pro-atrial natriuretic peptide (pro-ANP), brain natriuretic peptide (BNP), endothelin-1 (ET-1) and cardiac troponin I (TNI) in patients with pulmonary embolism (PE).
  52. ncbi Deep vein thrombosis and pulmonary embolism in two cohorts: the longitudinal investigation of thromboembolism etiology
    Mary Cushman
    Department of Medicine, University of Vermont, Burlington, USA
    Am J Med 117:19-25. 2004
    To determine the incidence of deep vein thrombosis and pulmonary embolism in two cohorts representing regions of the United States.
  53. ncbi Combined risk stratification with computerized tomography /echocardiography and biomarkers in patients with normotensive pulmonary embolism
    Savas Ozsu
    Karadeniz Technical University, School of Medicine, Department of Chest, Trabzon, Turkey
    Thromb Res 126:486-92. 2010
    ..computerized tomography (CT)/echocardiography or elevated biomarkers is associated with a poor prognosis for pulmonary embolism (PE)...
  54. ncbi Multidetector-row computed tomography in suspected pulmonary embolism
    Arnaud Perrier
    Service of General Internal Medicine, Geneva Faculty of Medicine and Geneva University Hospital, Geneva, Switzerland
    N Engl J Med 352:1760-8. 2005
    Single-detector-row computed tomography (CT) has a low sensitivity for pulmonary embolism and must be combined with venous-compression ultrasonography of the lower limbs...
  55. ncbi Contemporary management of pulmonary embolism: the answers to ten questions
    H Bounameaux
    Division of Angiology and Hemostasis, Department of Internal Medicine, University Hospitals of Geneva and Faculty of Medicine, Geneva, Switzerland
    J Intern Med 268:218-31. 2010
    b>Pulmonary embolism (PE) cannot be diagnosed solely on a clinical basis, because of the lack of sensitivity and specificity of clinical signs and symptoms. Pulmonary angiography is invasive and resource demanding...
  56. pmc Prospective evaluation of right ventricular function and functional status 6 months after acute submassive pulmonary embolism: frequency of persistent or subsequent elevation in estimated pulmonary artery pressure
    Jeffrey A Kline
    Department of Emergency Medicine, Emergency Medicine Research, Carolinas Medical Center, Charlotte, NC 28323 2861, USA
    Chest 136:1202-10. 2009
    ..have systematically documented pulmonary artery pressure over an intermediate time period after submassive pulmonary embolism (PE)...
  57. ncbi Comparison of outcomes after hospitalization for deep venous thrombosis or pulmonary embolism
    Susan Murin
    Thromb Haemost 88:407-14. 2002
    Venous thrombosis and pulmonary embolism are commonly viewed as different manifestations of a single disease process, venous thromboembolism...
  58. ncbi Risk factors associated with delayed diagnosis of acute pulmonary embolism
    Sean B Smith
    Department of Internal Medicine, Mayo Clinic College of Medicine, Rochester, Minnesota 55901, USA
    J Emerg Med 42:1-6. 2012
    Prompt diagnosis and treatment of acute pulmonary embolism (PE) is essential to reduce mortality. Risk factors for PE are well known, but factors associated with delayed diagnosis are less clear.
  59. ncbi Regional right ventricular dysfunction in acute pulmonary embolism and right ventricular infarction
    Franco Casazza
    Division of Cardiology, San Carlo Borromeo Hospital, via Pio 2, n 3, 20153 Milan, Italy
    Eur J Echocardiogr 6:11-4. 2005
    A normally contracting right ventricular apex associated to a severe hypokinesia of the mid-free wall ('McConnell sign') has been considered a distinct echocardiographic pattern of acute pulmonary embolism.
  60. ncbi Long-term complications of medical patients with hospital-acquired venous thromboembolism
    John Fanikos
    Department of Pharmacy, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Thromb Haemost 102:688-93. 2009
    ..at risk for VTE, we calculate that 122,235 were stricken with deep vein thrombosis (DVT) and 32,654 with pulmonary embolism (PE)...
  61. ncbi Pulmonary endarterectomy: experience and lessons learned in 1,500 cases
    Stuart W Jamieson
    Division of Cardiothoracic Surgery, Department of Anesthesia, UCSD Medical Center, San Diego, California, USA
    Ann Thorac Surg 76:1457-62; discussion 1462-4. 2003
    ..With the increased recognition of the disease and the success of operative therapy, however, more than 1,400 operations have been done since 1990 at our center...
  62. ncbi Derivation of a simple clinical model to categorize patients probability of pulmonary embolism: increasing the models utility with the SimpliRED D-dimer
    P S Wells
    Department of Medicine, University of Ottawa, Ontario, Canada
    Thromb Haemost 83:416-20. 2000
    ..demonstrated that a clinical model can be safely used in a management strategy in patients with suspected pulmonary embolism (PE)...
  63. pmc Gadolinium-enhanced magnetic resonance angiography for pulmonary embolism: a multicenter prospective study (PIOPED III)
    Paul D Stein
    Michigan State University, College of Osteopathic Medicine, Department of Internal Medicine, Michigan State University Venous Thromboembolism Research Unit, St Joseph Mercy Oakland Hospital, 44405 Woodward Avenue, Pontiac, MI 48341 5023, USA
    Ann Intern Med 152:434-43, W142-3. 2010
    The accuracy of gadolinium-enhanced magnetic resonance pulmonary angiography and magnetic resonance venography for diagnosing pulmonary embolism has not been determined conclusively.
  64. ncbi Risk assessment of recurrence in patients with unprovoked deep vein thrombosis or pulmonary embolism: the Vienna prediction model
    Sabine Eichinger
    Department of Internal Medicine I, the Karl Landsteiner Institut für Klinische Thromboseforschung, Wien, Austria
    Circulation 121:1630-6. 2010
    ..Predicting the risk of recurrent venous thromboembolism (VTE) in an individual patient is often not feasible. We aimed to develop a simple risk assessment model that improves prediction of the recurrence risk...
  65. ncbi Possible gender-related differences in the risk-to-benefit ratio of thrombolysis for acute submassive pulmonary embolism
    Annette Geibel
    Department of Cardiology and Angiology, Albert Ludwig University of Freiburg, Freiburg, Germany
    Am J Cardiol 99:103-7. 2007
    The indications for thrombolytic treatment in normotensive patients with pulmonary embolism (PE) are still the subject of debate, and it also remains questionable whether the efficacy and safety of thrombolysis are similar in men and ..
  66. ncbi Clinical predictors for fatal pulmonary embolism in 15,520 patients with venous thromboembolism: findings from the Registro Informatizado de la Enfermedad TromboEmbolica venosa (RIETE) Registry
    Silvy Laporte
    Clinical Pharmacology Department, Thrombosis Research Group, EA 3065, University Hospital of Saint Etienne Bellevue, 42055 Saint Etienne Cedex 02, France
    Circulation 117:1711-6. 2008
    Clinical predictors for fatal pulmonary embolism (PE) in patients with venous thromboembolism have never been studied.
  67. ncbi The risk of recurrent venous thromboembolism after discontinuing anticoagulation in patients with acute proximal deep vein thrombosis or pulmonary embolism. A prospective cohort study in 1,626 patients
    Paolo Prandoni
    Department of Medical and Surgical Sciences, University of Padua, Via Ospedale Civile 105, 35128, Padua, Italy
    Haematologica 92:199-205. 2007
    While it has long been recognized that patients with acute unprovoked deep vein thrombosis (DVT) or pulmonary embolism (PE) have a higher risk of recurrent venous thromboembolism (VTE) than that of patients with secondary thrombosis, ..
  68. pmc Epidemiology and risk factors for venous thrombosis
    Mary Cushman
    Department of Medicine, Thrombosis and Hemostasis Program, University of Vermont College of Medicine and Fletcher Allen Health Care, Burlington, VT, USA
    Semin Hematol 44:62-9. 2007
    Venous thrombosis, including deep vein thrombosis (DVT) and pulmonary embolism (PE), occurs at an annual incidence of about 1 per 1,000 adults...
  69. ncbi Diagnostic accuracy of D-dimer test for exclusion of venous thromboembolism: a systematic review
    M Di Nisio
    Department of Medicine and Aging, School of Medicine, and Aging Research Centre, Ce S I, Gabriele D Annunzio University Foundation, Chieti Pescara, Italy
    J Thromb Haemost 5:296-304. 2007
    The reported diagnostic accuracy of the D-dimer test for exclusion of deep vein thrombosis (DVT) and pulmonary embolism (PE) varies...
  70. ncbi Operative classification of thromboembolic disease determines outcome after pulmonary endarterectomy
    Patricia A Thistlethwaite
    Divisions of Cardiothoracic Surgery, Biostatistics, and Cardiology, University of California, San Diego, Calif 92103 8892, USA
    J Thorac Cardiovasc Surg 124:1203-11. 2002
    ..We sought to determine whether type and location of thromboembolic disease in the pulmonary vascular tree predicts the hemodynamic result and clinical outcome in patients undergoing pulmonary endarterectomy...
  71. ncbi Venous thromboembolism after acute stroke
    J Kelly
    Elderly Care Department, St. Thomas' Hospital, London, England
    Stroke 32:262-7. 2001
    ..Treatment for venous thromboembolism (VTE) is highly effective in preventing morbidity and mortality, yet pulmonary embolism (PE) accounts for up to 25% of early deaths after stroke...
  72. ncbi Venous thromboembolism and the risk of subsequent symptomatic atherosclerosis
    P Prandoni
    Department of Medical and Surgical Sciences, University Hospital of Padua, Padua, Italy
    J Thromb Haemost 4:1891-6. 2006
    ..We hypothesized that patients with VTE of unknown origin would be at a higher risk of developing symptomatic atherosclerosis than patients with VTE induced by known risk factors...
  73. ncbi Reverse right ventricular remodeling after pulmonary endarterectomy in patients with chronic thromboembolic pulmonary hypertension: utility of magnetic resonance imaging to demonstrate restoration of the right ventricle
    Herre J Reesink
    Department of Pulmonology of the Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Thorac Cardiovasc Surg 133:58-64. 2007
    ..We studied the effect of pulmonary endarterectomy on the restoration of right ventricular remodeling in patients with chronic thromboembolic pulmonary hypertension by magnetic resonance imaging...
  74. ncbi Perfusion abnormalities in pulmonary embolism studied with perfusion MRI and ventilation-perfusion scintigraphy: an intra-modality and inter-modality agreement study
    Tore Amundsen
    Department of Medicine, University Hospital of Trondheim, Norwegian University of Science and Technology, Trondheim, Norway
    J Magn Reson Imaging 15:386-94. 2002
    ..imaging (MRI) and ventilation-perfusion scintigraphy (V-P scan) in the study of perfusion abnormalities in pulmonary embolism (PE) and to compare the PE results to the findings previously reported for pneumonia and chronic obstructive ..
  75. ncbi Fatal pulmonary embolism after bariatric operations for morbid obesity: a 24-year retrospective analysis
    James A Sapala
    Department of Surgery, Harper University Hospital, Detroit Medical Center and Wayne State University School of Medicine, Detroit, MI, USA
    Obes Surg 13:819-25. 2003
    b>Pulmonary embolism (PE) is a leading cause of death following gastric bypass operations for morbid obesity...
  76. pmc Potential of an age adjusted D-dimer cut-off value to improve the exclusion of pulmonary embolism in older patients: a retrospective analysis of three large cohorts
    Renee A Douma
    Department of Vascular Medicine, Academic Medical Centre, Meibergdreef 9, 1105 AZ, Amsterdam, Netherlands
    BMJ 340:c1475. 2010
    In older patients, the the D-dimer test for pulmonary embolism has reduced specificity and is therefore less useful. In this study a new, age dependent cut-off value for the test was devised and its usefulness with older patients assessed.
  77. ncbi Clinical suspicion of fatal pulmonary embolism
    L A Pineda
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, School of Medicine and Biomedical Sciences, State University of New York at Buffalo, USA
    Chest 120:791-5. 2001
    BACKGROUND: Less than one third of patients with fatal pulmonary embolism (PE) are identified prior to autopsy...
  78. pmc Identification of putative endothelial progenitor cells (CD34+CD133+Flk-1+) in endarterectomized tissue of patients with chronic thromboembolic pulmonary hypertension
    Weijuan Yao
    Division of Pulmonary and Critical Care Medicine, Dept of Medicine, MTF 252, Univ of California, San Diego, 9200 Gilman Dr, MC 0725, La Jolla, CA 92093 0725, USA
    Am J Physiol Lung Cell Mol Physiol 296:L870-8. 2009
    ..It is possible that the microenvironment provided by thromboemboli may promote these putative progenitor cells to differentiate and enhance intimal remodeling...
  79. ncbi Excluding pulmonary embolism at the bedside without diagnostic imaging: management of patients with suspected pulmonary embolism presenting to the emergency department by using a simple clinical model and d-dimer
    P S Wells
    Division of Hematology, The Ottawa Hospital, Civic Campus, Suite 452, 737 Parkdale Avenue, Ottawa, Ontario K1Y 1J8, Canada
    Ann Intern Med 135:98-107. 2001
    ..standard, ventilation-perfusion lung scanning, complicate the management of patients with suspected pulmonary embolism. We previously demonstrated that determining the pretest probability can assist with management and that the ..
  80. ncbi Model-based cardiac diagnosis of pulmonary embolism
    C Starfinger
    Centre of Bioengineering, University of Canterbury, Christchurch, New Zealand
    Comput Methods Programs Biomed 87:46-60. 2007
    ..system (CVS) model and parameter identification method are then clinically validated on porcine data for pulmonary embolism. Errors for the identified model are within 10% when re-simulated and compared to clinical data...
  81. ncbi Complications of inferior vena cava filters
    Charles S Joels
    Department of General Surgery, Carolinas Medical Center, Charlotte, North Carolina 28203, USA
    Am Surg 69:654-9. 2003
    ..Overall, the benefits of preventing pulmonary embolism far exceed the risks related to filter placement in properly selected patients.
  82. ncbi Pulmonary embolism: what have we learned since Virchow? Natural history, pathophysiology, and diagnosis
    James E Dalen
    University of Arizona, 1840 East River Road, Suite 207, Tucson, AZ, USA
    Chest 122:1440-56. 2002
  83. ncbi Diagnosis, assessment, and treatment of non-pulmonary arterial hypertension pulmonary hypertension
    Marius M Hoeper
    Department of Respiratory Medicine, University of Hannover Medical School, Hannover, Germany
    J Am Coll Cardiol 54:S85-96. 2009
    ..Given the lack of robust clinical trials addressing PH in any of these conditions, it is important to conduct further studies to establish the role of medical therapy in non-PAH PH...
  84. ncbi Is the intravascular administration of mesenchymal stem cells safe? Mesenchymal stem cells and intravital microscopy
    Dario Furlani
    Department of Cardiac Surgery, Medical Faculty, University of Rostock Schillingallee 35, 18055 Rostock, Germany
    Microvasc Res 77:370-6. 2009
    ..40 and 25% animals died of pulmonary embolism respectively in both high and low MSCs dose groups, which was detected by histopathologic analysis of the ..
  85. pmc The venous thrombotic risk of oral contraceptives, effects of oestrogen dose and progestogen type: results of the MEGA case-control study
    A Van Hylckama Vlieg
    Department of Clinical Epidemiology, Leiden University Medical Center, C7 P, PO Box 9600, NL 2300 RC Leiden, Netherlands
    BMJ 339:b2921. 2009
    ..To assess the thrombotic risk associated with oral contraceptive use with a focus on dose of oestrogen and type of progestogen of oral contraceptives available in the Netherlands...
  86. ncbi Identification of patients at low risk for recurrent venous thromboembolism by measuring thrombin generation
    Gregor Hron
    Department of Internal Medicine I, Medical University of Vienna, Austria
    JAMA 296:397-402. 2006
    ..Because of the large number of risk factors, assessing the risk of recurrence in an individual patient is complex. A method covering multicausal thrombophilia is therefore required...
  87. ncbi ST-segment elevation in conditions other than acute myocardial infarction
    Kyuhyun Wang
    Hennepin County Medical Center, Cardiology Division, University of Minnesota, Minneapolis, MN 55415, USA
    N Engl J Med 349:2128-35. 2003
  88. ncbi Venous thromboembolism and subsequent hospitalisation due to acute arterial cardiovascular events: a 20-year cohort study
    Henrik Toft Sørensen
    Department of Clinical Epidemiology, Aarhus University Hospital, 8000 Aarhus C, Denmark
    Lancet 370:1773-9. 2007
    ..Other studies, however, do not show this association. To help clarify these discrepant findings, we aimed to investigate the risk of arterial cardiovascular events in patients who were diagnosed with venous thromboembolism...
  89. ncbi Dual-energy CT angiography of the lung in patients with suspected pulmonary embolism: initial results
    C Fink
    Institut fur Klinische Radiologie und Nuklearmedizin, Universitatsklinikum Mannheim, Universitat Heidelberg, Mannheim
    Rofo 180:879-83. 2008
    To evaluate the feasibility of dual-energy CT angiography (CTA) of the lung in patients with suspected pulmonary embolism (PE)...
  90. ncbi Fibrinolysis for patients with intermediate-risk pulmonary embolism
    Guy Meyer
    The authors affiliations are listed in the Appendix
    N Engl J Med 370:1402-11. 2014
    The role of fibrinolytic therapy in patients with intermediate-risk pulmonary embolism is controversial.
  91. ncbi Dual-energy CT for assessment of the severity of acute pulmonary embolism: pulmonary perfusion defect score compared with CT angiographic obstruction score and right ventricular/left ventricular diameter ratio
    Eun Jin Chae
    Department of Radiology and Research Institute of Radiology, University of Ulsan College of Medicine, Asan Medical Center, 388 1, Pungnap dong, Songpa Gu, Seoul 138 736, Republic of Korea
    AJR Am J Roentgenol 194:604-10. 2010
    The purpose of this study was to prospectively evaluate the usefulness of scoring perfusion defects on perfusion images at dual-energy CT for assessment of the severity of pulmonary embolism.
  92. ncbi Management of unsuccessful thrombolysis in acute massive pulmonary embolism
    Nicolas Meneveau
    FESC, Department of Cardiology, University Hospital Jean Minjoz, Blvd Fleming, 25030 Besancon Cedex, France
    Chest 129:1043-50. 2006
    The management of patients with acute massive pulmonary embolism (PE) who do not respond to fibrinolytic therapy remains unclear...
  93. ncbi Severity dependent increases in circulating cardiac troponin I and MMP-9 concentrations after experimental acute pulmonary thromboembolism
    Juliana A Uzuelli
    Department of Pharmacology, Faculty of Medicine of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, SP, Brazil
    Clin Chim Acta 388:184-8. 2008
    ..We examined whether the circulating concentrations of these biomarkers increase in proportion to the severity of experimental APT induced in anesthetized dogs...
  94. ncbi Superficial and deep venous thrombosis, pulmonary embolism and subsequent risk of cancer
    Henrik Toft Sørensen
    Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus N, Denmark
    Eur J Cancer 48:586-93. 2012
    In contrast to deep venous thrombosis and pulmonary embolism, superficial venous thrombosis has not been considered to be a marker of occult cancer. However, actual data regarding the association are very limited.
  95. ncbi Increased diagnosis of pulmonary embolism without a corresponding decline in mortality during the CT era
    A J Burge
    Department of Radiology, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, NY 10467, USA
    Clin Radiol 63:381-6. 2008
    To determine the association between the increasing computed tomography (CT) use for suspected pulmonary embolism (PE) on the annual rates of PE diagnosis and mortality, using time as a surrogate for CT use.
  96. ncbi Chronic obstructive pulmonary disease and deep vein thrombosis: a prevalent combination
    Ranjith Shetty
    Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
    J Thromb Thrombolysis 26:35-40. 2008
    ..Patients with chronic obstructive pulmonary disease (COPD) are at increased risk for venous thromboembolism (VTE). We analyzed a large US deep vein thrombosis (DVT) registry to explore the profile of patients with COPD and VTE...
  97. ncbi Prognostic significance of multidetector CT in normotensive patients with pulmonary embolism: results of the protect study
    David Jimenez
    Respiratory Department, Ramon y Cajal Hospital, IRYCIS, Madrid, Spain
    Thorax 69:109-15. 2014
    In patients with acute pulmonary embolism (PE), rapid and accurate risk assessment is paramount in selecting the appropriate treatment strategy...
  98. ncbi A computerized handheld decision-support system to improve pulmonary embolism diagnosis: a randomized trial
    Pierre Marie Roy
    Centre Hospitalier Universitaire d Angers and Université d Angers, Angers, France
    Ann Intern Med 151:677-86. 2009
    Testing for pulmonary embolism often differs from that recommended by evidence-based guidelines.
  99. ncbi Silent pulmonary embolism in patients with proximal deep vein thrombosis in the lower limbs
    I Tzoran
    Thrombosis and Hemostasis Unit, Rambam Health Care Campus Haifa, Haifa, Israel
    J Thromb Haemost 10:564-71. 2012
    One in every three patients with deep vein thrombosis (DVT) in the lower limbs may have silent pulmonary embolism (PE), but its clinical relevance has not been thoroughly studied.
  100. pmc Effect of computerized clinical decision support on the use and yield of CT pulmonary angiography in the emergency department
    Ali S Raja
    Center for Evidence Based Imaging and Department of Radiology, Brigham and Women s Hospital, 75 Francis St, Neville House 312 E, Boston, MA 02115, USA
    Radiology 262:468-74. 2012
    To determine the effect of evidence-based clinical decision support (CDS) on the use and yield of computed tomographic (CT) pulmonary angiography for acute pulmonary embolism (PE) in the emergency department (ED).
  101. ncbi Outpatient treatment of symptomatic pulmonary embolism: a systematic review and meta-analysis
    Siavash Piran
    Thrombosis Program, Division of Hematology, Department of Medicine, University of Ottawa, Ottawa, Canada
    Thromb Res 132:515-9. 2013
    ..However the role of outpatient treatment in patients diagnosed with a pulmonary embolism (PE) is controversial...

Research Grants65

  1. Right ventricular contractile dysfunction after pressure overload
    CLIFFORD RUSSELL GREYSON; Fiscal Year: 2013
    ..acute pulmonary hypertension is an important cause of morbidity and mortality in conditions such as massive pulmonary embolism, hypoxic pulmonary vasoconstriction, and following cardiopulmonary bypass and cardiac transplantation, but ..
  2. MOLECULAR BIOLOGY OF HUMAN COAGULATION FACTOR V
    Thomas Ortel; Fiscal Year: 2010
    ..to the pathogenesis of common clinical disorders such as myocardial infarction, deep vein thrombosis, pulmonary embolism, and stroke...
  3. Dual Direct Inhibitors of Thrombin and Factor Xa
    UMESH RAMANLAL DESAI; Fiscal Year: 2012
    ..Nearly 576,000 new cases of deep vein thrombosis and pulmonary embolism, two of the most common thrombotic conditions, are diagnosed every year in the US alone...
  4. Heme Oxygenase-1 in Lung Ischemia-Reperfusion Injury
    Patty J Lee; Fiscal Year: 2012
    ..the inciting event leading to acute lung injury during lung transplantation/surgery, thromboembolectomy, pulmonary embolism, and re-expansion pulmonary edema, all of which lead to clinically significant respiratory failure but for ..
  5. PET Imaging of Thrombus
    PETER D CARAVAN; Fiscal Year: 2013
    ..Thrombus is implicated in a range of pathologies, e.g. ischemic stroke, myocardial infarction, pulmonary embolism, and deep vein thrombosis...
  6. Proteolytic Pathways in Thrombus Resolution
    Toni M Antalis; Fiscal Year: 2013
    ..Along with the potentially fatal complication of pulmonary embolism, DVT frequently leads to a significant long- term complication for which we have no specific therapy, post-..
  7. Randomized trial of inhaled nitric oxide to treat acute pulmonary embolism
    Jeffrey A Kline; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Current standard treatment for acute pulmonary embolism (PE) focuses on anticoagulation to reduce clot extension...
  8. Reasons for Racial Disparities in Venous Thromboembolism
    NEIL ADRIAN ZAKAI; Fiscal Year: 2010
    ..According to the Surgeon General's 2008 Call to Action to Prevent Deep Venous Thrombosis and Pulmonary Embolism, over 300,000 Americans each year suffer from venous thromboembolism (VTE), with potentially over 100,000 ..
  9. Structural and Biochemical Basis of the Vitamin K cycle
    Weikai Li; Fiscal Year: 2013
    ..used oral anticoagulant for treating and preventing thrombosis diseases including deep vein thrombosis, pulmonary embolism, stroke, and myocardial infarction...
  10. High throughput assay for fibrin-binding probes
    PETER D CARAVAN; Fiscal Year: 2013
    ..g. ischemic stroke, myocardial infarction, pulmonary embolism, and deep vein thrombosis...
  11. Ultrasound Ablation on Bone Cancer Under CT Fluoroscopy
    Everette C Burdette; Fiscal Year: 2012
    ..e., atelectasis and pneumonia, deep venous thrombosis and pulmonary embolism. Surgical options are not possible for all patients, but when indicated, they consist of heavy interventions ..
  12. Genetic and Environmental Risk Factors for Venous Thromboembolism
    Christopher Kabrhel; Fiscal Year: 2013
    ..General of the United States who in 2008 issued a 'Call to Action to Prevent Deep Vein Thrombosis and Pulmonary Embolism'urging "more research on the causes, prevention, and treatment of deep vein thrombosis...
  13. Computer-Aided Detection of Pulmonary Embolism on CT Pulmonary Angiography
    Chuan Zhou; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Pulmonary embolism (PE) is one of leading cause of death in the United States if untreated. Prompt diagnosis and treatment can dramatically reduce the mortality rate and morbidity of the disease...
  14. Novel Methods for Dissolving Blood Clots
    GUY LELAND REED; Fiscal Year: 2013
    ..VTEs are blood clots in the legs (venous thrombosis) that may travel to the lungs (pulmonary embolism). It is estimated that 10-20% of VTE patients die, and the annual direct costs are up to $10 billion...
  15. Identifying novel genetic risk factors for venous thromboembolism (VTE)
    Jun Li; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Deep vein thrombosis (DVT) and pulmonary embolism (PE), collectively referred to as venous thromboembolism (VTE), is the third most common cause of vascular death in the US, after only heart attacks ..
  16. Clinical Trial Planning Grant in Catheter-Directed Thrombolysis of Occlusive DVT
    Marilyn J Manco-Johnson; Fiscal Year: 2013
    ..United States (US) Surgeon General's Call-to-Action on Prevention of Deep Venous Thrombosis (DVT) and Pulmonary Embolism (PE) emphasized chronic venous insufficiency following DVT as an important priority for future investigation...
  17. Antithrombotic Aptamers and Antidotes
    BRUCE ALAN SULLENGER; Fiscal Year: 2013
    ..including acute coronary syndromes (myocardial infarction and unstable angina), deep vein thrombosis, pulmonary embolism, and peripheral vascular disease...
  18. Anatomic Risk Factors for Venous Thromboembolism
    ANAND KUMAR NARAYAN; Fiscal Year: 2010
    ..When thrombi form and then break off, they can travel to the lungs, a condition known as pulmonary embolism, which represents leading cause of preventable death in the United States...
  19. Microvesicle production after trauma &its Clinical Impact on Venothromboembolism
    Myung S Park; Fiscal Year: 2013
    ..such as deep leg clots (also known as deep vein thrombosis) or clots lodged in the lung (also known as pulmonary embolism), collectively known as venous thromboembolism...
  20. Sensitive Measurement of Cardiac Troponin I at Point of Care: The Silicon BioDevi
    OCTAVIAN FLORESCU; Fiscal Year: 2012
    ..is critically important, the system will be able to measure a myriad of other biomarkers for heart failure, pulmonary embolism and deep vein thrombosis, sepsis and other conditions where speed, convenience and in the field measurement ..
  21. Stroke and aPL: Community-Based Clinicopathological Study
    STEVEN RICHARD LEVINE; Fiscal Year: 2012
    ..baseline aPL to be an independent risk factor for: (a) venous blood clots (deep venous thrombosis and pulmonary embolism) in men (Physicians Health Study) (Ginsburg et al 1992), (b) MI and stroke in men (Honolulu Heart Study) (..
  22. Ultrasound assisted thrombolysis for acute pulmonary embolism
    CURTIS GENSTLER; Fiscal Year: 2012
    ..drugs, including rt-PA, for catheter-directed thrombolysis of Deep Vein Thrombosis (DVT) and Massive Acute Pulmonary Embolism (PE). Chamsuddin et al...
  23. The Incidence and Progression of Peripheral Venous Disease
    Michael H Criqui; Fiscal Year: 2010
    ..We will separately determine the incidence of venous thrombosis and pulmonary embolism. Second, to evaluate risk factors for incident/progressive venous disease, focusing on risk factors ..
  24. Platelet adhesion to neutrophil extracellular DNA traps: role in thrombosis
    Denisa D Wagner; Fiscal Year: 2013
    ..We will study NETs as biomarkers in thrombosis. Thrombosis, including deep vein thrombosis/pulmonary embolism is now the biggest killer in the United States...
  25. Griffin: Venous Thromboembolism and mass spectrometry-based untargeted metabolomi
    JOHN H contact GRIFFIN; Fiscal Year: 2010
    ..7. Public Health Relevance: Deep vein thrombosis and pulmonary embolism (VTE) in the USA annually result in 500,000 hospitalizations and >50,000 deaths...
  26. Blood Transfusions: Gender Differences in Utilization, Predictors, and Outcomes
    Mary A M Rogers; Fiscal Year: 2010
    ..Information regarding blood transfusion, infection, and thrombotic events (deep-vein thrombosis, pulmonary embolism, transient ischemic attack, stroke, and myocardial infarction) will be extracted from CMS files...
  27. EPIDEMIOLOGY OF VENOUS THROMBOSIS AND PULMONARY EMBOLISM
    Aaron R Folsom; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Venous thromboembolism (VTE), comprising deep venous thrombosis and pulmonary embolism, is a major contributor to morbidity and mortality in the U.S...
  28. Predictive optimal anticlotting treatment for segmented patient populations
    Peter J Tonellato; Fiscal Year: 2013
    ..by applicant): Anticlotting drugs reduce risk to thrombosis and treat conditions that might lead to stroke, pulmonary embolism, deep vein thrombosis or other blood clotting related disease...
  29. Prevention and management of perioperative pulmonary embolism
    Vladimir R Muzykantov; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Pulmonary embolism (PE) is a common post-surgical complication for which management is suboptimal...
  30. Microparticle Docking in Pancreatic Cancer Induced VTE
    Julia E Geddings; Fiscal Year: 2013
    ..Venous thromboembolism (VTE) is a clinical term which refers to the development of deep vein thrombosis and pulmonary embolism. Pancreatic cancer patients have a high rate of VTE but the mechanism of VTE initiation and propagation has ..
  31. Reduction of Annexin A5 in Antipholipid Pregnancy Loss
    JACOB RAND; Fiscal Year: 2010
    ..a host of thrombotic complications including recurrent pregnancy losses, stroke, deep vein thrombosis and pulmonary embolism. The placental anticoagulant protein, annexin A5 (AnxAS) is a potent phospholipid (PL)-binding protein that ..
  32. A novel mechanism of coagulation in sickle cell disease
    JULIA BRITTAIN; Fiscal Year: 2012
    ..There also may be increased incidence of pulmonary embolism in SCD and histopathologic studies have suggested that large vessel narrowing with superimposed thrombosis ..
  33. DEVELOPMENT OF A FIRST-IN-CLASS TARGETED FIBRINOLYTIC FOR POST-SURGICAL THROMBOPR
    Ronald Carnemolla; Fiscal Year: 2013
    ..used in patients in the first hours after elective surgery for prophylaxis of deep vein thrombosis (DVT) and pulmonary embolism (PE)...
  34. Activation of encrypted tissue factor during thrombus formation in vivo
    CAMERON TRENOR; Fiscal Year: 2012
    ..Major causes of death, including stroke, heart attack and pulmonary embolism, are each linked to pathologic thrombosis...
  35. The Biochemistry and Physiology of Platelet TFPI
    SUSAN ANTONE MARONEY; Fiscal Year: 2013
    ..intravascular thrombosis that can result in common and severe diseases such as heart attack, stroke and pulmonary embolism. The long term goal of our proposed studies is to understand the role of TFPI produced by megakaryocytes and ..
  36. Identifying CT Imaging Biomarkers Associated with Prognosis of Pulmonary Embolism
    Kyongtae T Bae; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Identifying CT Imaging Biomarkers Associated with Prognosis of Pulmonary Embolism Abstract Venous thromboembolism (VTE), which clinically manifests as deep vein thrombosis (DVT) and pulmonary embolism ..
  37. Regional Lung Mechanics by 3D Image Registration
    Joseph M Reinhardt; Fiscal Year: 2010
    ..Pulmonary disease processes, including emphysema, interstitial fibrosis, cancer, pulmonary embolism, acute lung injury and more, alter the material properties of lung tissue and change the mechanics of the ..
  38. Does screening variability make DVT an unreliable quality measure of trauma care?
    Elliott R Haut; Fiscal Year: 2012
    ..patients, yet may be completely asymptomatic until the clot embolizes and causes sudden death from massive pulmonary embolism. Duplex ultrasound serves an important role as a noninvasive diagnostic tool for DVT detection...
  39. Estrogens and pharmacogenetic risks of venous thrombosis in postmenopausal women
    Nicholas L Smith; Fiscal Year: 2012
    ..30 to 89 years of age who experienced an incident VT, either deep vein thrombosis or fatal or non-fatal pulmonary embolism. This application will support the identification and the abstraction of medical record data VT cases and ..
  40. Role of Lipoprotein Receptors in Venous Thrombosis
    Dudley K Strickland; Fiscal Year: 2013
    ..Deep venous thrombosis (DVT) is a significant clinical problem that can also lead to potentially fatal pulmonary embolism. Clinical studies reveal that thrombus resolution is central to the pathogenesis of post- thrombotic ..
  41. Development of biomimetic oligomers as anticoagulant antagonists
    Richard W Scott; Fiscal Year: 2010
    LMWHs are being used with greater frequency to treat deep vein thrombosis, unstable angina, and acute pulmonary embolism, as well as thromboprophylaxis agents in a wide range of clinical situations including orthopedic surgery, high risk ..
  42. Outpatient Treatment of Low-Risk Patients with Pulmonary Embolism
    Donald M Yealy; Fiscal Year: 2010
    Description (provided by applicant): Pulmonary embolism (PE) affects many, with an estimated incidence of up to 69 cases per 100,000 persons annually. In the U.S...
  43. Venous thromboembolism among California cancer patients
    Helen Chew; Fiscal Year: 2003
    Venous thromboembolism (VTE, includes both venous thrombosis and pulmonary embolism) is a frequent complication among patients with cancer...
  44. Image-Guided Non-Invasive Ultrasonic Thrombolysis Using Histotripsy
    Zhen Xu; Fiscal Year: 2012
    ..to other clinical conditions requiring thrombolysis, including stroke, superficial vein thrombosis, pulmonary embolism, and dialysis graft thrombosis...
  45. PROSPECTIVE INVESTIGATION OF PULMONARY EMBOLISM DX II
    CHARLES HALES; Fiscal Year: 2003
    ..predictive value of contrast enhanced spiral computed tomography (spiral CT) for the diagnosis of acute pulmonary embolism (PE). Pulmonary embolism is common, yet frequently undiagnosed and fatal...
  46. LMWH for Post-partum Prophylaxis in Women at Risk of Venous Thrombosis
    Marc Rodger; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Pulmonary embolism (PE), the most serious form of venous thromboembolism (VTE), is a leading cause of maternal mortality in the developed world...
  47. 4D Magnetic Resonance Imaging for Atrial Flow Assessment in Atrial Fibrillation
    Jeffrey J Goldberger; Fiscal Year: 2013
    ..greater risk of LA versus RA appendage thrombus formation and the 10-fold greater risk of systemic versus pulmonary embolism in AF...
  48. Long Circulating Low Molecular Weight Heparins Pulmonary
    Fakhrul Ahsan; Fiscal Year: 2006
    ..Venous thromboembolism may manifest as deep vein thrombosis or pulmonary embolism. Fatality from a pulmonary embolism may occur within a few minutes of the onset of symptoms...
  49. Integrated Multifunctional Imaging of Deep Vein Thrombosis
    Walter Scott; Fiscal Year: 2009
    Deep venous thrombosis (DVT), and its sequelae, pulmonary embolism (PE), is a significant clinical problem, representing the leading cause of preventable in-hospital mortality in the USA and other developed countries...
  50. Cost Effectiveness of Anticoagulation Versus Genetic Testing of CYP2C9 & VKORC1 G
    Anna Teschemaker; Fiscal Year: 2009
    ..the criteria including patient age >18 years, confirmed clinical diagnosis of deep venous thrombosis or pulmonary embolism, warfarin therapy prescribed for at least 6 months, and an indication for target INR between 2 to 3...
  51. Minimally Invasive VAD for Treatment of Acute Right Heart Failure
    SCOTT C CORBETT; Fiscal Year: 2010
    ..Acute right heart failure is a significant clinical problem which often occurs in patients affected by pulmonary embolism, pulmonary hypertension, or heart attack, as well as in patients who have been treated with cardiopulmonary ..
  52. Identifying Low-Risk Patients with Pulmonary Embolism
    Drahomir Aujesky; Fiscal Year: 2005
    b>Pulmonary embolism (PE) is a common, costly, and potentially lethal disease in the US...
  53. Thrombin Formation Inhibitors
    James Phillips; Fiscal Year: 2004
    ..major dangers of DVT is that part of the clot may break off and travel to the heart and lungs promoting a pulmonary embolism (PE). There are approximately 5 million cases of DVT per year in United States with 600,000 cases of PE...
  54. Medical Decision Making: Roles of Evidence and Experience
    Benjamin Margolin Rottman; Fiscal Year: 2013
    ..and residents will engage in a series of simulated decisions about hypothetical patients who may have pulmonary embolism. Testing for pulmonary embolism involves a complicated set of decisions, and lab-based experiments will ..
  55. Antithrombotic Activity of Ascidian Glycosaminoglycans
    DOUGLAS TOLLEFSEN; Fiscal Year: 2004
    ..by applicant) Heparin from porcine or bovine tissues is used to treat diseases such as venous thrombosis, pulmonary embolism, and coronary artery thrombosis...
  56. PROSPECTIVE INVESTIGATION OF PULMONARY EMBOLISM DX-II
    Paul Stein; Fiscal Year: 2003
    ..predictive value of contrast enhanced spiral computed tomography (spiral CT) for the diagnosis of acute pulmonary embolism (PE). Pulmonary embolism is common, yet frequently undiagnosed and fatal...
  57. Prospective Investigation for Pulmonary Embolism Dx III
    Paul Stein; Fiscal Year: 2008
    ..abstract_text> ..
  58. PROSPECTIVE INVESTIGATION OF PE DX-II
    Kenneth Leeper; Fiscal Year: 2003
    ..predictive value of contrast enhanced spiral-computed tomography (spiral CT) scan for the diagnosis of acute pulmonary embolism (PE). PE is common, yet frequently undiagnosed and fatal...
  59. Development of an antidote-controlled FIXa inhibitor
    Christopher Rusconi; Fiscal Year: 2004
    ..diseases including acute coronary syndromes (heart attacks and unstable angina), deep vein thrombosis, pulmonary embolism, and peripheral vascular disease...
  60. Novel Recombinant Anticoagulant Proteins
    TZE CHEIN WUN; Fiscal Year: 2005
    ..conditions, such as unstable angina, acute myocardial infarction, ischemic stroke, deep vein thrombosis, pulmonary embolism, disseminated intravascular coagulation, and peripheral vascular disease...
  61. INFERIOR VENA CAVA FILTRATION WITH A REMOVABLE DEVICE
    Elvira Lang; Fiscal Year: 1999
    ..adapted from applicant's abstract): A removable inferior vena cava filter will be developed to prevent pulmonary embolism in patients who are temporarily at risk to develop this life-threatening complication...
  62. ORAL CONTRACEPTIVES AND THROMBOEMBOLIC DISEASE
    Stephen Sidney; Fiscal Year: 2000
    ..a) the relative and attributable risk of venous thromboembolic disease (deep venous thrombosis and pulmonary embolism) in current users of low-dose (<50 micrograms estrogen) oral contraceptive (OC) preparations; and b) the ..
  63. RIGHT VENTRICULAR DYSFUNCTION AFTER PRESSURE OVERLOAD
    Clifford Greyson; Fiscal Year: 2006
    ..acute RV pressure overload is an important cause of morbidity and mortality in conditions such as massive pulmonary embolism, hypoxic pulmonary vasoconstriction, and following cardiopulmonary bypass and cardiac transplantation...
  64. TAMOXIFEN--RISK OF MI, STROKE AND VENOUS THROMBOEMBOLISM
    Leslie Bernstein; Fiscal Year: 2001
    ..disease and stroke or increases risk of venous thromboembolic events (VTE: deep venous thrombophlebitis and pulmonary embolism) is uncertain. In the U.S...
  65. INCIDENCE AND OUTCOMES OF VENOUS THROMBOEMBOLISM
    MARC SILVERSTEIN; Fiscal Year: 1993
    Deep vein thrombosis (DVT) and pulmonary embolism (PE) most often occur during hospitalization for surgery or chronic medical conditions...