Genomes and Genes
Summary: Embolism in the pulmonary artery or one of its branches.
Publications392 found, 100 shown here
- Guidelines on the diagnosis and management of acute pulmonary embolism: the Task Force for the Diagnosis and Management of Acute Pulmonary Embolism of the European Society of Cardiology (ESC)Adam Torbicki
Department of Chest Medicine, Institute for Tuberculosis and Lung Diseases, Warsaw, Poland
Eur Heart J 29:2276-315. 2008..With the exception of severe air and fat embolism, the haemodynamic consequences of non-thrombotic emboli are usually mild. Treatment is mostly supportive but may differ according to the type of embolic material and clinical severity...
- Multidetector computed tomography for acute pulmonary embolismPaul D Stein
Department of Research, St Joseph Mercy Oakland Hospital, Pontiac, Mich, USA
N Engl J Med 354:2317-27. 2006The accuracy of multidetector computed tomographic angiography (CTA) for the diagnosis of acute pulmonary embolism has not been determined conclusively.
- Chronic thromboembolic pulmonary hypertensionMarius M Hoeper
Department of Respiratory Medicine, Hannover Medical School, 30623 Hannover, Germany
Circulation 113:2011-20. 2006
- Oral, direct Factor Xa inhibition with BAY 59-7939 for the prevention of venous thromboembolism after total hip replacementB I Eriksson
Sahlgrenska University HospitalOstra, Gothenburg, Sweden
J Thromb Haemost 4:121-8. 2006..Joint replacement surgery is an appropriate model for dose-ranging studies investigating new anticoagulants...
- Venous thromboembolism: disease burden, outcomes and risk factorsJ A Heit
Division of Cardiovascular Diseases Section of Vascular Diseases, Department of Internal Medicine, Mayo Clinic and Mayo Foundation, Rochester, MN 55905, USA
J Thromb Haemost 3:1611-7. 2005..incidence), outcomes (survival, recurrence and complications) and risk factors for deep vein thrombosis and pulmonary embolism occurring in the community...
- The epidemiology of venous thromboembolismRichard H White
University of California, Davis, Sacramento, California, USA
Circulation 107:I4-8. 2003..5%) per 100,000 persons at age 80 years. Approximately one third of patients with symptomatic VTE manifest pulmonary embolism (PE), whereas two thirds manifest deep vein thrombosis (DVT) alone...
- Antithrombotic therapy for venous thromboembolic disease: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition)Clive Kearon
Hamilton Health Sciences, Henderson Division, 711 Concession Street, Hamilton, Ontario, Canada
Chest 133:454S-545S. 2008..in this chapter are the following: for patients with objectively confirmed deep vein thrombosis (DVT) or pulmonary embolism (PE), we recommend anticoagulant therapy with subcutaneous (SC) low-molecular-weight heparin (LMWH), ..
- Pulmonary embolism and deep vein thrombosisSamuel Z Goldhaber
Brigham and Women s Hospital, Department of Medicine, Harvard Medical School, Cardiovascular Division, Boston, MA 02115, USA
Lancet 379:1835-46. 2012b>Pulmonary embolism is the third most common cause of death from cardiovascular disease after heart attack and stroke...
- Rivaroxaban versus enoxaparin for thromboprophylaxis after hip arthroplastyBengt I Eriksson
Sahlgrenska University Hospital Ostra, Gothenburg, Sweden
N Engl J Med 358:2765-75. 2008..This phase 3 trial compared the efficacy and safety of rivaroxaban, an oral direct inhibitor of factor Xa, with those of enoxaparin for extended thromboprophylaxis in patients undergoing total hip arthroplasty...
- Risk factors for deep vein thrombosis and pulmonary embolism: a population-based case-control studyJ A Heit
Division of Cardiovascular Diseases, Mayo Clinic and Mayo Foundation, Rochester, Minn 55905, USA
Arch Intern Med 160:809-15. 2000..Reported risk factors for venous thromboembolism (VTE) vary widely, and the magnitude and independence of each are uncertain...
- Simplification of the pulmonary embolism severity index for prognostication in patients with acute symptomatic pulmonary embolismDavid Jimenez
Respiratory Department, Hospital Ramón y Cajal and Alcalá de Henares University, 28034 Madrid, Spain
Arch Intern Med 170:1383-9. 2010The Pulmonary Embolism Severity Index (PESI) estimates the risk of 30-day mortality in patients with acute pulmonary embolism (PE). We constructed a simplified version of the PESI.
- Rivaroxaban versus enoxaparin for thromboprophylaxis after total knee arthroplastyMichael R Lassen
Nordsjaellands Hospital, Hørsholm, Denmark
N Engl J Med 358:2776-86. 2008..We investigated the efficacy of rivaroxaban, an orally active direct factor Xa inhibitor, in preventing venous thrombosis after total knee arthroplasty...
- Venous thromboembolism (VTE) in Europe. The number of VTE events and associated morbidity and mortalityAlexander T Cohen
Vascular Medicine, Department of Surgery, King s College Hospital, London, SE5 9RS, UK
Thromb Haemost 98:756-64. 2007..EU countries was 465,715 (404,664-538,189) cases of deep-vein thrombosis, 295,982 (242,450-360,363) cases of pulmonary embolism (PE), and 370,012 (300,193-483,108) VTE-related deaths...
- Prognostic value of echocardiographically assessed right ventricular dysfunction in patients with pulmonary embolismMarije Ten Wolde
Department of Vascular Medicine, Academic Medical Center, Amsterdam, The Netherlands
Arch Intern Med 164:1685-9. 2004..dysfunction is increasingly used to guide more aggressive therapy in hemodynamically stable patients with acute pulmonary embolism (PE). However, the prognostic value of right ventricular dysfunction in these patients is still unclear.
- Highly sensitive troponin T assay in normotensive patients with acute pulmonary embolismMareike Lankeit
Department of Cardiology and Pulmonology, University of Gottingen, 37099 Gottingen, Germany
Eur Heart J 31:1836-44. 2010To assess the role of cardiac troponin T (cTnT) levels on admission using a new, highly sensitive assay (hsTnT) in the risk assessment of normotensive patients with acute pulmonary embolism (PE).
- Prevalence of pulmonary embolism in acute exacerbations of COPD: a systematic review and metaanalysisJacques Rizkallah
Department of Medicine, Respiratory Division, University of British Columbia, Heart and Lung Center, James Hogg iCAPTURE Center for Cardiovascular and Pulmonary Research at St Paul s Hospital, 1081 Burrard Street, Vancouver, BC, Canada
Chest 135:786-93. 2009Nearly 30% of all exacerbations of COPD do not have a clear etiology. Although pulmonary embolism (PE) can exacerbate respiratory symptoms such as dyspnea and chest pain, and COPD patients are at a high risk for PE due to a variety of ..
- Patient outcomes after deep vein thrombosis and pulmonary embolism: the Worcester Venous Thromboembolism StudyFrederick A Spencer
Department of Medicine, McMaster University, Faculty of Health Sciences and Blood Institute, Hamilton, ON, Canada
Arch Intern Med 168:425-30. 2008Despite advances in the management of deep vein thrombosis (DVT) and pulmonary embolism (PE), relatively few contemporary data describe and compare outcomes in patients with these common conditions from a more generalizable community-..
- Acute pulmonary embolismVictor F Tapson
Division of Pulmonary and Critical Care Medicine, Duke University Medical Center, Durham, NC 27710, USA
N Engl J Med 358:1037-52. 2008
- Predictors of survival after deep vein thrombosis and pulmonary embolism: a population-based, cohort studyJ A Heit
Department of Medicine, Mayo Clinic and Mayo Foundation, Rochester, Minn 55905, USA
Arch Intern Med 159:445-53. 1999....
- Malignancies, prothrombotic mutations, and the risk of venous thrombosisJeanet W Blom
Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands
JAMA 293:715-22. 2005..Venous thrombosis is a common complication in patients with cancer, leading to additional morbidity and compromising quality of life...
- Prognostic value of troponins in acute pulmonary embolism: a meta-analysisCecilia Becattini
Medicina Interna e Cardiovascolare, Dipartimento di Medicina Interna, University of Perugia, Via G Dottori 1, 06129 Perugia, Italy
Circulation 116:427-33. 2007Whether elevated serum troponin levels identify patients with acute pulmonary embolism at high risk of short-term mortality or adverse outcome is undefined.
- Evaluation of D-dimer in the diagnosis of suspected deep-vein thrombosisPhilip S Wells
Department of Medicine, Ottawa Hospital, University of Ottawa, Ottawa, Ont, Canada
N Engl J Med 349:1227-35. 2003....
- Usefulness of admission red cell distribution width as a predictor of early mortality in patients with acute pulmonary embolismAli Zorlu
Department of Cardiology, Cumhuriyet University Medical School, Sivas, Turkey
Am J Cardiol 109:128-34. 2012..However, its prognostic significance in acute pulmonary embolism (PE) is unknown...
- Prognostic value of right ventricular dysfunction in patients with haemodynamically stable pulmonary embolism: a systematic reviewOlivier Sanchez
Division of Respiratory and Intensive Care Medicine, Georges Pompidou European Hospital, 75015 Paris, France
Eur Heart J 29:1569-77. 2008..assessed by echocardiography or spiral computed tomography (CT), or by increased levels of cardiac biomarkers [troponin, brain natriuretic peptide (BNP) and pro-BNP] in patients with haemodynamically stable pulmonary embolism (PE).
- Prognostic importance of hyponatremia in patients with acute pulmonary embolismNathalie Scherz
Division of General Internal Medicine, University of Lausanne, Lausanne, Switzerland
Am J Respir Crit Care Med 182:1178-83. 2010Although associated with adverse outcomes in other cardiopulmonary conditions, the prognostic value of hyponatremia, a marker of neurohormonal activation, in patients with acute pulmonary embolism (PE) is unknown.
- Enoxaparin followed by once-weekly idrabiotaparinux versus enoxaparin plus warfarin for patients with acute symptomatic pulmonary embolism: a randomised, double-blind, double-dummy, non-inferiority trialHarry R Buller
Department of Vascular Medicine, Academic Medical Centre, Amsterdam, Netherlands
Lancet 379:123-9. 2012Treatment of pulmonary embolism with low-molecular-weight heparin and vitamin K antagonists, such as warfarin, is not ideal...
- Outpatient versus inpatient treatment for patients with acute pulmonary embolism: an international, open-label, randomised, non-inferiority trialDrahomir Aujesky
Bern University Hospital, Switzerland
Lancet 378:41-8. 2011Although practice guidelines recommend outpatient care for selected, haemodynamically stable patients with pulmonary embolism, most treatment is presently inpatient based...
- Time trends in pulmonary embolism in the United States: evidence of overdiagnosisRenda Soylemez Wiener
The Pulmonary Center, Boston University School of Medicine, Massachusetts 02118, USA
Arch Intern Med 171:831-7. 2011Computed tomographic pulmonary angiography (CTPA) may improve detection of life-threatening pulmonary embolism (PE), but this sensitive test may have a downside: overdiagnosis and overtreatment (finding clinically unimportant emboli and ..
- Acute pulmonary embolism to the subsegmental level: diagnostic accuracy of three MRI techniques compared with 16-MDCTAlexander Kluge
Department of Diagnostic Radiology, Kerckhoff Heart Center, Benekestrasse 2 8, Bad Nauheim, Germany 61231
AJR Am J Roentgenol 187:W7-14. 2006The purpose of this study was to assess the individual and combined usefulness of MRI techniques in cases of acute pulmonary embolism and to compare the usefulness of these techniques with that of 16-MDCT.
- Incidence and risk factors for fatal pulmonary embolism after major trauma: a nested cohort studyK M Ho
Department of Intensive Care Medicine, School of Population Health, University of Western Australia, Australia
Br J Anaesth 105:596-602. 2010Venous thromboembolism is common after major trauma. Strategies to prevent fatal pulmonary embolism (PE) are widely utilized, but the incidence and risk factors for fatal PE are poorly understood.
- CT angiography of pulmonary arteries to detect pulmonary embolism: improvement of vascular enhancement with low kilovoltage settingsClaudia Schueller-Weidekamm
Department of Radiology, University Hospital of Vienna, Vienna, Austria
Radiology 241:899-907. 2006....
- Major pulmonary embolism: review of a pathophysiologic approach to the golden hour of hemodynamically significant pulmonary embolismKenneth E Wood
Department of Medicine, University of Wisconsin Hospitals and Clinics, Madison, WI 53792, USA
Chest 121:877-905. 2002Major pulmonary embolism (PE) results whenever the combination of embolism size and underlying cardiopulmonary status interact to produce hemodynamic instability...
- Derivation and validation of a prognostic model for pulmonary embolismDrahomir Aujesky
Division of General Internal Medicine, Clinical Epidemiology Center, University of Lausanne, Lausanne, Switzerland
Am J Respir Crit Care Med 172:1041-6. 2005An objective and simple prognostic model for patients with pulmonary embolism could be helpful in guiding initial intensity of treatment.
- Prospective multicenter evaluation of the pulmonary embolism rule-out criteriaJ A Kline
Department of Emergency Medicine, Carolinas Medical Center, Charlotte, NC 28323 2861, USA
J Thromb Haemost 6:772-80. 2008Over-investigation of low-risk patients with suspected pulmonary embolism (PE) represents a growing problem...
- Relative impact of risk factors for deep vein thrombosis and pulmonary embolism: a population-based studyJohn A Heit
Hematology Research, Stabile 660, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA
Arch Intern Med 162:1245-8. 2002..risk (defined as the percentage of all cases of a disease in a population that can be "attributed" to a risk factor) for deep vein thrombosis and pulmonary embolism associated with venous thromboembolism risk factors.
- Chronic dialysis patients have high risk for pulmonary embolismDaniel P Tveit
Nephrology Service, Walter Reed Army Medical Center, Washington, DC 20307 5001, USA
Am J Kidney Dis 39:1011-7. 2002b>Pulmonary embolism has been considered uncommon in chronic dialysis patients, but has not been adequately studied in a large population...
- Pulmonary embolism and pneumonia may be confounded after acute stroke and may co-existJames Kelly
Elderly Care Department and Haematology Department, North Wing 9th Floor, St Thomas Hospital, Lambeth Palace Road, Lambeth, London SE1 7EH, UK
Age Ageing 31:235-9. 2002b>Pulmonary embolism and pneumonia are prevalent complications after acute stroke that overlap significantly in their timing, risk factors and clinical features...
- Detection of pulmonary embolism using dual-energy computed tomography and correlation with cardiovascular measurements: a preliminary studyLong Jiang Zhang
Department of Medical Imaging, Jinling Hospital, Clinical School of Medical College, Nanjing University, Nanjing, Jiangsu Province, China
Acta Radiol 50:892-901. 2009Detection of a suspected pulmonary embolism (PE) has been the focus of considerable research over the past few decades...
- Prospective validation of the Pulmonary Embolism Severity Index. A clinical prognostic model for pulmonary embolismJacques Donzé
Service de Medecine Interne, Centre Hospitalier Universitaire Vaudois, 1011 Lausanne, Switzerland
Thromb Haemost 100:943-8. 2008Practice guidelines recommend outpatient care for selected patients with non-massive pulmonary embolism (PE), but fail to specify how these low-risk patients should be identified. Using data from U.S...
- Lung perfusion with dual-energy multidetector-row CT (MDCT): feasibility for the evaluation of acute pulmonary embolism in 117 consecutive patientsFrancois Pontana
Department of Thoracic Imaging, Hospital Calmette, University Center of Lille, Boulevard Jules Leclercq, 59037 Lille Cedex, France
Acad Radiol 15:1494-504. 2008To investigate the accuracy of dual-energy computed tomography in the depiction of perfusion defects in patients with acute pulmonary embolism (PE).
- Preadmission hyperglycemia is an independent risk factor for in-hospital symptomatic pulmonary embolism after major orthopedic surgeryBoris Mraovic
Department of Anesthesiology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
J Arthroplasty 25:64-70. 2010We investigate whether preadmission hyperglycemia is a risk factor for developing in-hospital symptomatic pulmonary embolism after major orthopedic surgery...
- The prevalence of clinically relevant incidental findings on chest computed tomographic angiograms ordered to diagnose pulmonary embolismWilliam B Hall
Division of Pulmonary and Critical Care Medicine, University of North Carolina at Chapel Hill, Campus Box 7020, 130 Mason Farm Rd, Chapel Hill, NC 27514
Arch Intern Med 169:1961-5. 2009Chest computed tomographic angiograms (CTAs) are frequently ordered for evaluation of suspected pulmonary embolism (PE) in the emergency department, but non-PE findings are often noted...
- Risk of recurrent venous thromboembolism and mortality in patients with cancer incidentally diagnosed with pulmonary embolism: a comparison with symptomatic patientsPaul L den Exter
Leiden University Medical Center, Leiden, The Netherlands
J Clin Oncol 29:2405-9. 2011The routine use of modern computed tomography scanners has led to an increased detection of incidental pulmonary embolism (PE), in particular in patients with cancer. The clinical relevance of these incidental findings is unknown.
- Prospective study of the incidence of contrast-induced nephropathy among patients evaluated for pulmonary embolism by contrast-enhanced computed tomographyAlice M Mitchell
Department of Emergency Medicine, Carolinas HealthCare System, Charlotte, NC, USA
Acad Emerg Med 19:618-25. 2012..CECT) of the pulmonary arteries (CTPA) has become the mainstay to evaluate patients with suspected pulmonary embolism (PE) and is one of the most common CECT imaging studies performed in the emergency department (ED)...
- Symptomatic in-hospital deep vein thrombosis and pulmonary embolism following hip and knee arthroplasty among patients receiving recommended prophylaxis: a systematic reviewJean Marie Januel
Institute of Social and Preventive Medicine, Lausanne University Hospital, Switzerland
JAMA 307:294-303. 2012..Symptomatic venous thromboembolism (VTE) after total or partial knee arthroplasty (TPKA) and after total or partial hip arthroplasty (TPHA) are proposed patient safety indicators, but its incidence prior to discharge is not defined...
- Diagnosis and management of isolated subsegmental pulmonary embolism: review and assessment of the optionsPaul D Stein
Department of Research, St Mary Mercy Hospital, Livonia, MI 48154, USA
Clin Appl Thromb Hemost 18:20-6. 2012We assessed the potential safety of withholding treatment of pulmonary embolism (PE) limited to subsegmental branches...
- Clinical presentation and outcome of venous thromboembolism in COPDL Bertoletti
Groupe de Recherche sur la Thrombose, EA3065, Universite de Saint Etienne, 42000 Saint Etienne, France
Eur Respir J 39:862-8. 2012..The clinical presentation of VTE, namely pulmonary embolism (PE) or deep venous thrombosis (DVT), and the outcome at 3 months (death, recurrent VTE or bleeding) were ..
- Performance of 4 clinical decision rules in the diagnostic management of acute pulmonary embolism: a prospective cohort studyRenee A Douma
Academic Medical Center, Amsterdam, The Netherlands
Ann Intern Med 154:709-18. 2011Several clinical decision rules (CDRs) are available to exclude acute pulmonary embolism (PE), but they have not been directly compared.
- Pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertension: pathophysiologyM Humbert
Univ Paris Sud, Faculte de Medecine, Kremlin Bicetre, 2AP HP, Centre National de Référence de l Hypertension Pulmonaire Sévère, Service de Pneumologie et Reanimation Respiratoire, Hopital Antoine Beclere, Clamart, France
Eur Respir Rev 19:59-63. 2010..Further research into these similarities is needed to assist the development of targeted pharmacological therapies for patients with inoperable CTEPH and patients who have persistent pulmonary hypertension after endarterectomy...
- The challenge of diagnosing pulmonary embolism in elderly patients: influence of age on commonly used diagnostic tests and strategiesMarc Righini
Division of Angiology and Hemostasis, Geneva University Hospital and Faculty of Medicine, Geneva, Switzerland
J Am Geriatr Soc 53:1039-45. 2005b>Pulmonary embolism (PE) is a potentially fatal disease if left untreated...
- ANP, BNP and D-dimer predict right ventricular dysfunction in patients with acute pulmonary embolismHenrik Gutte
Department of Clinical Physiology, Nuclear Medicine and PET, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark
Clin Physiol Funct Imaging 30:466-72. 2010..ventricular dysfunction (RVD) using plasma concentration of D-dimer, pro-atrial natriuretic peptide (pro-ANP), brain natriuretic peptide (BNP), endothelin-1 (ET-1) and cardiac troponin I (TNI) in patients with pulmonary embolism (PE).
- Deep vein thrombosis and pulmonary embolism in two cohorts: the longitudinal investigation of thromboembolism etiologyMary Cushman
Department of Medicine, University of Vermont, Burlington, USA
Am J Med 117:19-25. 2004To determine the incidence of deep vein thrombosis and pulmonary embolism in two cohorts representing regions of the United States.
- Combined risk stratification with computerized tomography /echocardiography and biomarkers in patients with normotensive pulmonary embolismSavas Ozsu
Karadeniz Technical University, School of Medicine, Department of Chest, Trabzon, Turkey
Thromb Res 126:486-92. 2010..computerized tomography (CT)/echocardiography or elevated biomarkers is associated with a poor prognosis for pulmonary embolism (PE)...
- Multidetector-row computed tomography in suspected pulmonary embolismArnaud Perrier
Service of General Internal Medicine, Geneva Faculty of Medicine and Geneva University Hospital, Geneva, Switzerland
N Engl J Med 352:1760-8. 2005Single-detector-row computed tomography (CT) has a low sensitivity for pulmonary embolism and must be combined with venous-compression ultrasonography of the lower limbs...
- Contemporary management of pulmonary embolism: the answers to ten questionsH Bounameaux
Division of Angiology and Hemostasis, Department of Internal Medicine, University Hospitals of Geneva and Faculty of Medicine, Geneva, Switzerland
J Intern Med 268:218-31. 2010b>Pulmonary embolism (PE) cannot be diagnosed solely on a clinical basis, because of the lack of sensitivity and specificity of clinical signs and symptoms. Pulmonary angiography is invasive and resource demanding...
- Prospective evaluation of right ventricular function and functional status 6 months after acute submassive pulmonary embolism: frequency of persistent or subsequent elevation in estimated pulmonary artery pressureJeffrey A Kline
Department of Emergency Medicine, Emergency Medicine Research, Carolinas Medical Center, Charlotte, NC 28323 2861, USA
Chest 136:1202-10. 2009..have systematically documented pulmonary artery pressure over an intermediate time period after submassive pulmonary embolism (PE)...
- Comparison of outcomes after hospitalization for deep venous thrombosis or pulmonary embolismSusan Murin
Thromb Haemost 88:407-14. 2002Venous thrombosis and pulmonary embolism are commonly viewed as different manifestations of a single disease process, venous thromboembolism...
- Risk factors associated with delayed diagnosis of acute pulmonary embolismSean B Smith
Department of Internal Medicine, Mayo Clinic College of Medicine, Rochester, Minnesota 55901, USA
J Emerg Med 42:1-6. 2012Prompt diagnosis and treatment of acute pulmonary embolism (PE) is essential to reduce mortality. Risk factors for PE are well known, but factors associated with delayed diagnosis are less clear.
- Regional right ventricular dysfunction in acute pulmonary embolism and right ventricular infarctionFranco Casazza
Division of Cardiology, San Carlo Borromeo Hospital, via Pio 2, n 3, 20153 Milan, Italy
Eur J Echocardiogr 6:11-4. 2005A normally contracting right ventricular apex associated to a severe hypokinesia of the mid-free wall ('McConnell sign') has been considered a distinct echocardiographic pattern of acute pulmonary embolism.
- Long-term complications of medical patients with hospital-acquired venous thromboembolismJohn Fanikos
Department of Pharmacy, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
Thromb Haemost 102:688-93. 2009..at risk for VTE, we calculate that 122,235 were stricken with deep vein thrombosis (DVT) and 32,654 with pulmonary embolism (PE)...
- Pulmonary endarterectomy: experience and lessons learned in 1,500 casesStuart W Jamieson
Division of Cardiothoracic Surgery, Department of Anesthesia, UCSD Medical Center, San Diego, California, USA
Ann Thorac Surg 76:1457-62; discussion 1462-4. 2003..With the increased recognition of the disease and the success of operative therapy, however, more than 1,400 operations have been done since 1990 at our center...
- Derivation of a simple clinical model to categorize patients probability of pulmonary embolism: increasing the models utility with the SimpliRED D-dimerP S Wells
Department of Medicine, University of Ottawa, Ontario, Canada
Thromb Haemost 83:416-20. 2000..demonstrated that a clinical model can be safely used in a management strategy in patients with suspected pulmonary embolism (PE)...
- Gadolinium-enhanced magnetic resonance angiography for pulmonary embolism: a multicenter prospective study (PIOPED III)Paul D Stein
Michigan State University, College of Osteopathic Medicine, Department of Internal Medicine, Michigan State University Venous Thromboembolism Research Unit, St Joseph Mercy Oakland Hospital, 44405 Woodward Avenue, Pontiac, MI 48341 5023, USA
Ann Intern Med 152:434-43, W142-3. 2010The accuracy of gadolinium-enhanced magnetic resonance pulmonary angiography and magnetic resonance venography for diagnosing pulmonary embolism has not been determined conclusively.
- Risk assessment of recurrence in patients with unprovoked deep vein thrombosis or pulmonary embolism: the Vienna prediction modelSabine Eichinger
Department of Internal Medicine I, the Karl Landsteiner Institut für Klinische Thromboseforschung, Wien, Austria
Circulation 121:1630-6. 2010..Predicting the risk of recurrent venous thromboembolism (VTE) in an individual patient is often not feasible. We aimed to develop a simple risk assessment model that improves prediction of the recurrence risk...
- Possible gender-related differences in the risk-to-benefit ratio of thrombolysis for acute submassive pulmonary embolismAnnette Geibel
Department of Cardiology and Angiology, Albert Ludwig University of Freiburg, Freiburg, Germany
Am J Cardiol 99:103-7. 2007The indications for thrombolytic treatment in normotensive patients with pulmonary embolism (PE) are still the subject of debate, and it also remains questionable whether the efficacy and safety of thrombolysis are similar in men and ..
- Clinical predictors for fatal pulmonary embolism in 15,520 patients with venous thromboembolism: findings from the Registro Informatizado de la Enfermedad TromboEmbolica venosa (RIETE) RegistrySilvy Laporte
Clinical Pharmacology Department, Thrombosis Research Group, EA 3065, University Hospital of Saint Etienne Bellevue, 42055 Saint Etienne Cedex 02, France
Circulation 117:1711-6. 2008Clinical predictors for fatal pulmonary embolism (PE) in patients with venous thromboembolism have never been studied.
- The risk of recurrent venous thromboembolism after discontinuing anticoagulation in patients with acute proximal deep vein thrombosis or pulmonary embolism. A prospective cohort study in 1,626 patientsPaolo Prandoni
Department of Medical and Surgical Sciences, University of Padua, Via Ospedale Civile 105, 35128, Padua, Italy
Haematologica 92:199-205. 2007While it has long been recognized that patients with acute unprovoked deep vein thrombosis (DVT) or pulmonary embolism (PE) have a higher risk of recurrent venous thromboembolism (VTE) than that of patients with secondary thrombosis, ..
- Epidemiology and risk factors for venous thrombosisMary Cushman
Department of Medicine, Thrombosis and Hemostasis Program, University of Vermont College of Medicine and Fletcher Allen Health Care, Burlington, VT, USA
Semin Hematol 44:62-9. 2007Venous thrombosis, including deep vein thrombosis (DVT) and pulmonary embolism (PE), occurs at an annual incidence of about 1 per 1,000 adults...
- Diagnostic accuracy of D-dimer test for exclusion of venous thromboembolism: a systematic reviewM Di Nisio
Department of Medicine and Aging, School of Medicine, and Aging Research Centre, Ce S I, Gabriele D Annunzio University Foundation, Chieti Pescara, Italy
J Thromb Haemost 5:296-304. 2007The reported diagnostic accuracy of the D-dimer test for exclusion of deep vein thrombosis (DVT) and pulmonary embolism (PE) varies...
- Operative classification of thromboembolic disease determines outcome after pulmonary endarterectomyPatricia A Thistlethwaite
Divisions of Cardiothoracic Surgery, Biostatistics, and Cardiology, University of California, San Diego, Calif 92103 8892, USA
J Thorac Cardiovasc Surg 124:1203-11. 2002..We sought to determine whether type and location of thromboembolic disease in the pulmonary vascular tree predicts the hemodynamic result and clinical outcome in patients undergoing pulmonary endarterectomy...
- Venous thromboembolism after acute strokeJ Kelly
Elderly Care Department, St. Thomas' Hospital, London, England
Stroke 32:262-7. 2001..Treatment for venous thromboembolism (VTE) is highly effective in preventing morbidity and mortality, yet pulmonary embolism (PE) accounts for up to 25% of early deaths after stroke...
- Venous thromboembolism and the risk of subsequent symptomatic atherosclerosisP Prandoni
Department of Medical and Surgical Sciences, University Hospital of Padua, Padua, Italy
J Thromb Haemost 4:1891-6. 2006..We hypothesized that patients with VTE of unknown origin would be at a higher risk of developing symptomatic atherosclerosis than patients with VTE induced by known risk factors...
- Reverse right ventricular remodeling after pulmonary endarterectomy in patients with chronic thromboembolic pulmonary hypertension: utility of magnetic resonance imaging to demonstrate restoration of the right ventricleHerre J Reesink
Department of Pulmonology of the Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
J Thorac Cardiovasc Surg 133:58-64. 2007..We studied the effect of pulmonary endarterectomy on the restoration of right ventricular remodeling in patients with chronic thromboembolic pulmonary hypertension by magnetic resonance imaging...
- Perfusion abnormalities in pulmonary embolism studied with perfusion MRI and ventilation-perfusion scintigraphy: an intra-modality and inter-modality agreement studyTore Amundsen
Department of Medicine, University Hospital of Trondheim, Norwegian University of Science and Technology, Trondheim, Norway
J Magn Reson Imaging 15:386-94. 2002..imaging (MRI) and ventilation-perfusion scintigraphy (V-P scan) in the study of perfusion abnormalities in pulmonary embolism (PE) and to compare the PE results to the findings previously reported for pneumonia and chronic obstructive ..
- Fatal pulmonary embolism after bariatric operations for morbid obesity: a 24-year retrospective analysisJames A Sapala
Department of Surgery, Harper University Hospital, Detroit Medical Center and Wayne State University School of Medicine, Detroit, MI, USA
Obes Surg 13:819-25. 2003b>Pulmonary embolism (PE) is a leading cause of death following gastric bypass operations for morbid obesity...
- Potential of an age adjusted D-dimer cut-off value to improve the exclusion of pulmonary embolism in older patients: a retrospective analysis of three large cohortsRenee A Douma
Department of Vascular Medicine, Academic Medical Centre, Meibergdreef 9, 1105 AZ, Amsterdam, Netherlands
BMJ 340:c1475. 2010In older patients, the the D-dimer test for pulmonary embolism has reduced specificity and is therefore less useful. In this study a new, age dependent cut-off value for the test was devised and its usefulness with older patients assessed.
- Clinical suspicion of fatal pulmonary embolismL A Pineda
Division of Pulmonary and Critical Care Medicine, Department of Medicine, School of Medicine and Biomedical Sciences, State University of New York at Buffalo, USA
Chest 120:791-5. 2001BACKGROUND: Less than one third of patients with fatal pulmonary embolism (PE) are identified prior to autopsy...
- Identification of putative endothelial progenitor cells (CD34+CD133+Flk-1+) in endarterectomized tissue of patients with chronic thromboembolic pulmonary hypertensionWeijuan Yao
Division of Pulmonary and Critical Care Medicine, Dept of Medicine, MTF 252, Univ of California, San Diego, 9200 Gilman Dr, MC 0725, La Jolla, CA 92093 0725, USA
Am J Physiol Lung Cell Mol Physiol 296:L870-8. 2009..It is possible that the microenvironment provided by thromboemboli may promote these putative progenitor cells to differentiate and enhance intimal remodeling...
- Excluding pulmonary embolism at the bedside without diagnostic imaging: management of patients with suspected pulmonary embolism presenting to the emergency department by using a simple clinical model and d-dimerP S Wells
Division of Hematology, The Ottawa Hospital, Civic Campus, Suite 452, 737 Parkdale Avenue, Ottawa, Ontario K1Y 1J8, Canada
Ann Intern Med 135:98-107. 2001..standard, ventilation-perfusion lung scanning, complicate the management of patients with suspected pulmonary embolism. We previously demonstrated that determining the pretest probability can assist with management and that the ..
- Model-based cardiac diagnosis of pulmonary embolismC Starfinger
Centre of Bioengineering, University of Canterbury, Christchurch, New Zealand
Comput Methods Programs Biomed 87:46-60. 2007..system (CVS) model and parameter identification method are then clinically validated on porcine data for pulmonary embolism. Errors for the identified model are within 10% when re-simulated and compared to clinical data...
- Complications of inferior vena cava filtersCharles S Joels
Department of General Surgery, Carolinas Medical Center, Charlotte, North Carolina 28203, USA
Am Surg 69:654-9. 2003..Overall, the benefits of preventing pulmonary embolism far exceed the risks related to filter placement in properly selected patients.
- Pulmonary embolism: what have we learned since Virchow? Natural history, pathophysiology, and diagnosisJames E Dalen
University of Arizona, 1840 East River Road, Suite 207, Tucson, AZ, USA
Chest 122:1440-56. 2002
- Diagnosis, assessment, and treatment of non-pulmonary arterial hypertension pulmonary hypertensionMarius M Hoeper
Department of Respiratory Medicine, University of Hannover Medical School, Hannover, Germany
J Am Coll Cardiol 54:S85-96. 2009..Given the lack of robust clinical trials addressing PH in any of these conditions, it is important to conduct further studies to establish the role of medical therapy in non-PAH PH...
- Is the intravascular administration of mesenchymal stem cells safe? Mesenchymal stem cells and intravital microscopyDario Furlani
Department of Cardiac Surgery, Medical Faculty, University of Rostock Schillingallee 35, 18055 Rostock, Germany
Microvasc Res 77:370-6. 2009..40 and 25% animals died of pulmonary embolism respectively in both high and low MSCs dose groups, which was detected by histopathologic analysis of the ..
- The venous thrombotic risk of oral contraceptives, effects of oestrogen dose and progestogen type: results of the MEGA case-control studyA Van Hylckama Vlieg
Department of Clinical Epidemiology, Leiden University Medical Center, C7 P, PO Box 9600, NL 2300 RC Leiden, Netherlands
BMJ 339:b2921. 2009..To assess the thrombotic risk associated with oral contraceptive use with a focus on dose of oestrogen and type of progestogen of oral contraceptives available in the Netherlands...
- Identification of patients at low risk for recurrent venous thromboembolism by measuring thrombin generationGregor Hron
Department of Internal Medicine I, Medical University of Vienna, Austria
JAMA 296:397-402. 2006..Because of the large number of risk factors, assessing the risk of recurrence in an individual patient is complex. A method covering multicausal thrombophilia is therefore required...
- ST-segment elevation in conditions other than acute myocardial infarctionKyuhyun Wang
Hennepin County Medical Center, Cardiology Division, University of Minnesota, Minneapolis, MN 55415, USA
N Engl J Med 349:2128-35. 2003
- Venous thromboembolism and subsequent hospitalisation due to acute arterial cardiovascular events: a 20-year cohort studyHenrik Toft Sørensen
Department of Clinical Epidemiology, Aarhus University Hospital, 8000 Aarhus C, Denmark
Lancet 370:1773-9. 2007..Other studies, however, do not show this association. To help clarify these discrepant findings, we aimed to investigate the risk of arterial cardiovascular events in patients who were diagnosed with venous thromboembolism...
- Dual-energy CT angiography of the lung in patients with suspected pulmonary embolism: initial resultsC Fink
Institut fur Klinische Radiologie und Nuklearmedizin, Universitatsklinikum Mannheim, Universitat Heidelberg, Mannheim
Rofo 180:879-83. 2008To evaluate the feasibility of dual-energy CT angiography (CTA) of the lung in patients with suspected pulmonary embolism (PE)...
- Fibrinolysis for patients with intermediate-risk pulmonary embolismGuy Meyer
The authors affiliations are listed in the Appendix
N Engl J Med 370:1402-11. 2014The role of fibrinolytic therapy in patients with intermediate-risk pulmonary embolism is controversial.
- Dual-energy CT for assessment of the severity of acute pulmonary embolism: pulmonary perfusion defect score compared with CT angiographic obstruction score and right ventricular/left ventricular diameter ratioEun Jin Chae
Department of Radiology and Research Institute of Radiology, University of Ulsan College of Medicine, Asan Medical Center, 388 1, Pungnap dong, Songpa Gu, Seoul 138 736, Republic of Korea
AJR Am J Roentgenol 194:604-10. 2010The purpose of this study was to prospectively evaluate the usefulness of scoring perfusion defects on perfusion images at dual-energy CT for assessment of the severity of pulmonary embolism.
- Management of unsuccessful thrombolysis in acute massive pulmonary embolismNicolas Meneveau
FESC, Department of Cardiology, University Hospital Jean Minjoz, Blvd Fleming, 25030 Besancon Cedex, France
Chest 129:1043-50. 2006The management of patients with acute massive pulmonary embolism (PE) who do not respond to fibrinolytic therapy remains unclear...
- Severity dependent increases in circulating cardiac troponin I and MMP-9 concentrations after experimental acute pulmonary thromboembolismJuliana A Uzuelli
Department of Pharmacology, Faculty of Medicine of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, SP, Brazil
Clin Chim Acta 388:184-8. 2008..We examined whether the circulating concentrations of these biomarkers increase in proportion to the severity of experimental APT induced in anesthetized dogs...
- Superficial and deep venous thrombosis, pulmonary embolism and subsequent risk of cancerHenrik Toft Sørensen
Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus N, Denmark
Eur J Cancer 48:586-93. 2012In contrast to deep venous thrombosis and pulmonary embolism, superficial venous thrombosis has not been considered to be a marker of occult cancer. However, actual data regarding the association are very limited.
- Increased diagnosis of pulmonary embolism without a corresponding decline in mortality during the CT eraA J Burge
Department of Radiology, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, NY 10467, USA
Clin Radiol 63:381-6. 2008To determine the association between the increasing computed tomography (CT) use for suspected pulmonary embolism (PE) on the annual rates of PE diagnosis and mortality, using time as a surrogate for CT use.
- Chronic obstructive pulmonary disease and deep vein thrombosis: a prevalent combinationRanjith Shetty
Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
J Thromb Thrombolysis 26:35-40. 2008..Patients with chronic obstructive pulmonary disease (COPD) are at increased risk for venous thromboembolism (VTE). We analyzed a large US deep vein thrombosis (DVT) registry to explore the profile of patients with COPD and VTE...
- Prognostic significance of multidetector CT in normotensive patients with pulmonary embolism: results of the protect studyDavid Jimenez
Respiratory Department, Ramon y Cajal Hospital, IRYCIS, Madrid, Spain
Thorax 69:109-15. 2014In patients with acute pulmonary embolism (PE), rapid and accurate risk assessment is paramount in selecting the appropriate treatment strategy...
- A computerized handheld decision-support system to improve pulmonary embolism diagnosis: a randomized trialPierre Marie Roy
Centre Hospitalier Universitaire d Angers and Université d Angers, Angers, France
Ann Intern Med 151:677-86. 2009Testing for pulmonary embolism often differs from that recommended by evidence-based guidelines.
- Silent pulmonary embolism in patients with proximal deep vein thrombosis in the lower limbsI Tzoran
Thrombosis and Hemostasis Unit, Rambam Health Care Campus Haifa, Haifa, Israel
J Thromb Haemost 10:564-71. 2012One in every three patients with deep vein thrombosis (DVT) in the lower limbs may have silent pulmonary embolism (PE), but its clinical relevance has not been thoroughly studied.
- Effect of computerized clinical decision support on the use and yield of CT pulmonary angiography in the emergency departmentAli S Raja
Center for Evidence Based Imaging and Department of Radiology, Brigham and Women s Hospital, 75 Francis St, Neville House 312 E, Boston, MA 02115, USA
Radiology 262:468-74. 2012To determine the effect of evidence-based clinical decision support (CDS) on the use and yield of computed tomographic (CT) pulmonary angiography for acute pulmonary embolism (PE) in the emergency department (ED).
- Outpatient treatment of symptomatic pulmonary embolism: a systematic review and meta-analysisSiavash Piran
Thrombosis Program, Division of Hematology, Department of Medicine, University of Ottawa, Ottawa, Canada
Thromb Res 132:515-9. 2013..However the role of outpatient treatment in patients diagnosed with a pulmonary embolism (PE) is controversial...
- Right ventricular contractile dysfunction after pressure overloadCLIFFORD RUSSELL GREYSON; Fiscal Year: 2013..acute pulmonary hypertension is an important cause of morbidity and mortality in conditions such as massive pulmonary embolism, hypoxic pulmonary vasoconstriction, and following cardiopulmonary bypass and cardiac transplantation, but ..
- MOLECULAR BIOLOGY OF HUMAN COAGULATION FACTOR VThomas Ortel; Fiscal Year: 2010..to the pathogenesis of common clinical disorders such as myocardial infarction, deep vein thrombosis, pulmonary embolism, and stroke...
- Dual Direct Inhibitors of Thrombin and Factor XaUMESH RAMANLAL DESAI; Fiscal Year: 2012..Nearly 576,000 new cases of deep vein thrombosis and pulmonary embolism, two of the most common thrombotic conditions, are diagnosed every year in the US alone...
- Heme Oxygenase-1 in Lung Ischemia-Reperfusion InjuryPatty J Lee; Fiscal Year: 2012..the inciting event leading to acute lung injury during lung transplantation/surgery, thromboembolectomy, pulmonary embolism, and re-expansion pulmonary edema, all of which lead to clinically significant respiratory failure but for ..
- PET Imaging of ThrombusPETER D CARAVAN; Fiscal Year: 2013..Thrombus is implicated in a range of pathologies, e.g. ischemic stroke, myocardial infarction, pulmonary embolism, and deep vein thrombosis...
- Proteolytic Pathways in Thrombus ResolutionToni M Antalis; Fiscal Year: 2013..Along with the potentially fatal complication of pulmonary embolism, DVT frequently leads to a significant long- term complication for which we have no specific therapy, post-..
- Randomized trial of inhaled nitric oxide to treat acute pulmonary embolismJeffrey A Kline; Fiscal Year: 2013DESCRIPTION (provided by applicant): Current standard treatment for acute pulmonary embolism (PE) focuses on anticoagulation to reduce clot extension...
- Reasons for Racial Disparities in Venous ThromboembolismNEIL ADRIAN ZAKAI; Fiscal Year: 2010..According to the Surgeon General's 2008 Call to Action to Prevent Deep Venous Thrombosis and Pulmonary Embolism, over 300,000 Americans each year suffer from venous thromboembolism (VTE), with potentially over 100,000 ..
- Structural and Biochemical Basis of the Vitamin K cycleWeikai Li; Fiscal Year: 2013..used oral anticoagulant for treating and preventing thrombosis diseases including deep vein thrombosis, pulmonary embolism, stroke, and myocardial infarction...
- High throughput assay for fibrin-binding probesPETER D CARAVAN; Fiscal Year: 2013..g. ischemic stroke, myocardial infarction, pulmonary embolism, and deep vein thrombosis...
- Ultrasound Ablation on Bone Cancer Under CT FluoroscopyEverette C Burdette; Fiscal Year: 2012..e., atelectasis and pneumonia, deep venous thrombosis and pulmonary embolism. Surgical options are not possible for all patients, but when indicated, they consist of heavy interventions ..
- Genetic and Environmental Risk Factors for Venous ThromboembolismChristopher Kabrhel; Fiscal Year: 2013..General of the United States who in 2008 issued a 'Call to Action to Prevent Deep Vein Thrombosis and Pulmonary Embolism'urging "more research on the causes, prevention, and treatment of deep vein thrombosis...
- Computer-Aided Detection of Pulmonary Embolism on CT Pulmonary AngiographyChuan Zhou; Fiscal Year: 2012DESCRIPTION (provided by applicant): Pulmonary embolism (PE) is one of leading cause of death in the United States if untreated. Prompt diagnosis and treatment can dramatically reduce the mortality rate and morbidity of the disease...
- Novel Methods for Dissolving Blood ClotsGUY LELAND REED; Fiscal Year: 2013..VTEs are blood clots in the legs (venous thrombosis) that may travel to the lungs (pulmonary embolism). It is estimated that 10-20% of VTE patients die, and the annual direct costs are up to $10 billion...
- Identifying novel genetic risk factors for venous thromboembolism (VTE)Jun Li; Fiscal Year: 2013DESCRIPTION (provided by applicant): Deep vein thrombosis (DVT) and pulmonary embolism (PE), collectively referred to as venous thromboembolism (VTE), is the third most common cause of vascular death in the US, after only heart attacks ..
- Clinical Trial Planning Grant in Catheter-Directed Thrombolysis of Occlusive DVTMarilyn J Manco-Johnson; Fiscal Year: 2013..United States (US) Surgeon General's Call-to-Action on Prevention of Deep Venous Thrombosis (DVT) and Pulmonary Embolism (PE) emphasized chronic venous insufficiency following DVT as an important priority for future investigation...
- Antithrombotic Aptamers and AntidotesBRUCE ALAN SULLENGER; Fiscal Year: 2013..including acute coronary syndromes (myocardial infarction and unstable angina), deep vein thrombosis, pulmonary embolism, and peripheral vascular disease...
- Anatomic Risk Factors for Venous ThromboembolismANAND KUMAR NARAYAN; Fiscal Year: 2010..When thrombi form and then break off, they can travel to the lungs, a condition known as pulmonary embolism, which represents leading cause of preventable death in the United States...
- Microvesicle production after trauma &its Clinical Impact on VenothromboembolismMyung S Park; Fiscal Year: 2013..such as deep leg clots (also known as deep vein thrombosis) or clots lodged in the lung (also known as pulmonary embolism), collectively known as venous thromboembolism...
- Sensitive Measurement of Cardiac Troponin I at Point of Care: The Silicon BioDeviOCTAVIAN FLORESCU; Fiscal Year: 2012..is critically important, the system will be able to measure a myriad of other biomarkers for heart failure, pulmonary embolism and deep vein thrombosis, sepsis and other conditions where speed, convenience and in the field measurement ..
- Stroke and aPL: Community-Based Clinicopathological StudySTEVEN RICHARD LEVINE; Fiscal Year: 2012..baseline aPL to be an independent risk factor for: (a) venous blood clots (deep venous thrombosis and pulmonary embolism) in men (Physicians Health Study) (Ginsburg et al 1992), (b) MI and stroke in men (Honolulu Heart Study) (..
- Ultrasound assisted thrombolysis for acute pulmonary embolismCURTIS GENSTLER; Fiscal Year: 2012..drugs, including rt-PA, for catheter-directed thrombolysis of Deep Vein Thrombosis (DVT) and Massive Acute Pulmonary Embolism (PE). Chamsuddin et al...
- The Incidence and Progression of Peripheral Venous DiseaseMichael H Criqui; Fiscal Year: 2010..We will separately determine the incidence of venous thrombosis and pulmonary embolism. Second, to evaluate risk factors for incident/progressive venous disease, focusing on risk factors ..
- Platelet adhesion to neutrophil extracellular DNA traps: role in thrombosisDenisa D Wagner; Fiscal Year: 2013..We will study NETs as biomarkers in thrombosis. Thrombosis, including deep vein thrombosis/pulmonary embolism is now the biggest killer in the United States...
- Griffin: Venous Thromboembolism and mass spectrometry-based untargeted metabolomiJOHN H contact GRIFFIN; Fiscal Year: 2010..7. Public Health Relevance: Deep vein thrombosis and pulmonary embolism (VTE) in the USA annually result in 500,000 hospitalizations and >50,000 deaths...
- Blood Transfusions: Gender Differences in Utilization, Predictors, and OutcomesMary A M Rogers; Fiscal Year: 2010..Information regarding blood transfusion, infection, and thrombotic events (deep-vein thrombosis, pulmonary embolism, transient ischemic attack, stroke, and myocardial infarction) will be extracted from CMS files...
- EPIDEMIOLOGY OF VENOUS THROMBOSIS AND PULMONARY EMBOLISMAaron R Folsom; Fiscal Year: 2013DESCRIPTION (provided by applicant): Venous thromboembolism (VTE), comprising deep venous thrombosis and pulmonary embolism, is a major contributor to morbidity and mortality in the U.S...
- Predictive optimal anticlotting treatment for segmented patient populationsPeter J Tonellato; Fiscal Year: 2013..by applicant): Anticlotting drugs reduce risk to thrombosis and treat conditions that might lead to stroke, pulmonary embolism, deep vein thrombosis or other blood clotting related disease...
- Prevention and management of perioperative pulmonary embolismVladimir R Muzykantov; Fiscal Year: 2013DESCRIPTION (provided by applicant): Pulmonary embolism (PE) is a common post-surgical complication for which management is suboptimal...
- Microparticle Docking in Pancreatic Cancer Induced VTEJulia E Geddings; Fiscal Year: 2013..Venous thromboembolism (VTE) is a clinical term which refers to the development of deep vein thrombosis and pulmonary embolism. Pancreatic cancer patients have a high rate of VTE but the mechanism of VTE initiation and propagation has ..
- Reduction of Annexin A5 in Antipholipid Pregnancy LossJACOB RAND; Fiscal Year: 2010..a host of thrombotic complications including recurrent pregnancy losses, stroke, deep vein thrombosis and pulmonary embolism. The placental anticoagulant protein, annexin A5 (AnxAS) is a potent phospholipid (PL)-binding protein that ..
- A novel mechanism of coagulation in sickle cell diseaseJULIA BRITTAIN; Fiscal Year: 2012..There also may be increased incidence of pulmonary embolism in SCD and histopathologic studies have suggested that large vessel narrowing with superimposed thrombosis ..
- DEVELOPMENT OF A FIRST-IN-CLASS TARGETED FIBRINOLYTIC FOR POST-SURGICAL THROMBOPRRonald Carnemolla; Fiscal Year: 2013..used in patients in the first hours after elective surgery for prophylaxis of deep vein thrombosis (DVT) and pulmonary embolism (PE)...
- Activation of encrypted tissue factor during thrombus formation in vivoCAMERON TRENOR; Fiscal Year: 2012..Major causes of death, including stroke, heart attack and pulmonary embolism, are each linked to pathologic thrombosis...
- The Biochemistry and Physiology of Platelet TFPISUSAN ANTONE MARONEY; Fiscal Year: 2013..intravascular thrombosis that can result in common and severe diseases such as heart attack, stroke and pulmonary embolism. The long term goal of our proposed studies is to understand the role of TFPI produced by megakaryocytes and ..
- Identifying CT Imaging Biomarkers Associated with Prognosis of Pulmonary EmbolismKyongtae T Bae; Fiscal Year: 2012DESCRIPTION (provided by applicant): Identifying CT Imaging Biomarkers Associated with Prognosis of Pulmonary Embolism Abstract Venous thromboembolism (VTE), which clinically manifests as deep vein thrombosis (DVT) and pulmonary embolism ..
- Regional Lung Mechanics by 3D Image RegistrationJoseph M Reinhardt; Fiscal Year: 2010..Pulmonary disease processes, including emphysema, interstitial fibrosis, cancer, pulmonary embolism, acute lung injury and more, alter the material properties of lung tissue and change the mechanics of the ..
- Does screening variability make DVT an unreliable quality measure of trauma care?Elliott R Haut; Fiscal Year: 2012..patients, yet may be completely asymptomatic until the clot embolizes and causes sudden death from massive pulmonary embolism. Duplex ultrasound serves an important role as a noninvasive diagnostic tool for DVT detection...
- Estrogens and pharmacogenetic risks of venous thrombosis in postmenopausal womenNicholas L Smith; Fiscal Year: 2012..30 to 89 years of age who experienced an incident VT, either deep vein thrombosis or fatal or non-fatal pulmonary embolism. This application will support the identification and the abstraction of medical record data VT cases and ..
- Role of Lipoprotein Receptors in Venous ThrombosisDudley K Strickland; Fiscal Year: 2013..Deep venous thrombosis (DVT) is a significant clinical problem that can also lead to potentially fatal pulmonary embolism. Clinical studies reveal that thrombus resolution is central to the pathogenesis of post- thrombotic ..
- Development of biomimetic oligomers as anticoagulant antagonistsRichard W Scott; Fiscal Year: 2010LMWHs are being used with greater frequency to treat deep vein thrombosis, unstable angina, and acute pulmonary embolism, as well as thromboprophylaxis agents in a wide range of clinical situations including orthopedic surgery, high risk ..
- Outpatient Treatment of Low-Risk Patients with Pulmonary EmbolismDonald M Yealy; Fiscal Year: 2010Description (provided by applicant): Pulmonary embolism (PE) affects many, with an estimated incidence of up to 69 cases per 100,000 persons annually. In the U.S...
- Venous thromboembolism among California cancer patientsHelen Chew; Fiscal Year: 2003Venous thromboembolism (VTE, includes both venous thrombosis and pulmonary embolism) is a frequent complication among patients with cancer...
- Image-Guided Non-Invasive Ultrasonic Thrombolysis Using HistotripsyZhen Xu; Fiscal Year: 2012..to other clinical conditions requiring thrombolysis, including stroke, superficial vein thrombosis, pulmonary embolism, and dialysis graft thrombosis...
- PROSPECTIVE INVESTIGATION OF PULMONARY EMBOLISM DX IICHARLES HALES; Fiscal Year: 2003..predictive value of contrast enhanced spiral computed tomography (spiral CT) for the diagnosis of acute pulmonary embolism (PE). Pulmonary embolism is common, yet frequently undiagnosed and fatal...
- LMWH for Post-partum Prophylaxis in Women at Risk of Venous ThrombosisMarc Rodger; Fiscal Year: 2012DESCRIPTION (provided by applicant): Pulmonary embolism (PE), the most serious form of venous thromboembolism (VTE), is a leading cause of maternal mortality in the developed world...
- 4D Magnetic Resonance Imaging for Atrial Flow Assessment in Atrial FibrillationJeffrey J Goldberger; Fiscal Year: 2013..greater risk of LA versus RA appendage thrombus formation and the 10-fold greater risk of systemic versus pulmonary embolism in AF...
- Long Circulating Low Molecular Weight Heparins PulmonaryFakhrul Ahsan; Fiscal Year: 2006..Venous thromboembolism may manifest as deep vein thrombosis or pulmonary embolism. Fatality from a pulmonary embolism may occur within a few minutes of the onset of symptoms...
- Integrated Multifunctional Imaging of Deep Vein ThrombosisWalter Scott; Fiscal Year: 2009Deep venous thrombosis (DVT), and its sequelae, pulmonary embolism (PE), is a significant clinical problem, representing the leading cause of preventable in-hospital mortality in the USA and other developed countries...
- Cost Effectiveness of Anticoagulation Versus Genetic Testing of CYP2C9 & VKORC1 GAnna Teschemaker; Fiscal Year: 2009..the criteria including patient age >18 years, confirmed clinical diagnosis of deep venous thrombosis or pulmonary embolism, warfarin therapy prescribed for at least 6 months, and an indication for target INR between 2 to 3...
- Minimally Invasive VAD for Treatment of Acute Right Heart FailureSCOTT C CORBETT; Fiscal Year: 2010..Acute right heart failure is a significant clinical problem which often occurs in patients affected by pulmonary embolism, pulmonary hypertension, or heart attack, as well as in patients who have been treated with cardiopulmonary ..
- Identifying Low-Risk Patients with Pulmonary EmbolismDrahomir Aujesky; Fiscal Year: 2005b>Pulmonary embolism (PE) is a common, costly, and potentially lethal disease in the US...
- Thrombin Formation InhibitorsJames Phillips; Fiscal Year: 2004..major dangers of DVT is that part of the clot may break off and travel to the heart and lungs promoting a pulmonary embolism (PE). There are approximately 5 million cases of DVT per year in United States with 600,000 cases of PE...
- Medical Decision Making: Roles of Evidence and ExperienceBenjamin Margolin Rottman; Fiscal Year: 2013..and residents will engage in a series of simulated decisions about hypothetical patients who may have pulmonary embolism. Testing for pulmonary embolism involves a complicated set of decisions, and lab-based experiments will ..
- Antithrombotic Activity of Ascidian GlycosaminoglycansDOUGLAS TOLLEFSEN; Fiscal Year: 2004..by applicant) Heparin from porcine or bovine tissues is used to treat diseases such as venous thrombosis, pulmonary embolism, and coronary artery thrombosis...
- PROSPECTIVE INVESTIGATION OF PULMONARY EMBOLISM DX-IIPaul Stein; Fiscal Year: 2003..predictive value of contrast enhanced spiral computed tomography (spiral CT) for the diagnosis of acute pulmonary embolism (PE). Pulmonary embolism is common, yet frequently undiagnosed and fatal...
- Prospective Investigation for Pulmonary Embolism Dx IIIPaul Stein; Fiscal Year: 2008..abstract_text> ..
- PROSPECTIVE INVESTIGATION OF PE DX-IIKenneth Leeper; Fiscal Year: 2003..predictive value of contrast enhanced spiral-computed tomography (spiral CT) scan for the diagnosis of acute pulmonary embolism (PE). PE is common, yet frequently undiagnosed and fatal...
- Development of an antidote-controlled FIXa inhibitorChristopher Rusconi; Fiscal Year: 2004..diseases including acute coronary syndromes (heart attacks and unstable angina), deep vein thrombosis, pulmonary embolism, and peripheral vascular disease...
- Novel Recombinant Anticoagulant ProteinsTZE CHEIN WUN; Fiscal Year: 2005..conditions, such as unstable angina, acute myocardial infarction, ischemic stroke, deep vein thrombosis, pulmonary embolism, disseminated intravascular coagulation, and peripheral vascular disease...
- INFERIOR VENA CAVA FILTRATION WITH A REMOVABLE DEVICEElvira Lang; Fiscal Year: 1999..adapted from applicant's abstract): A removable inferior vena cava filter will be developed to prevent pulmonary embolism in patients who are temporarily at risk to develop this life-threatening complication...
- ORAL CONTRACEPTIVES AND THROMBOEMBOLIC DISEASEStephen Sidney; Fiscal Year: 2000..a) the relative and attributable risk of venous thromboembolic disease (deep venous thrombosis and pulmonary embolism) in current users of low-dose (<50 micrograms estrogen) oral contraceptive (OC) preparations; and b) the ..
- RIGHT VENTRICULAR DYSFUNCTION AFTER PRESSURE OVERLOADClifford Greyson; Fiscal Year: 2006..acute RV pressure overload is an important cause of morbidity and mortality in conditions such as massive pulmonary embolism, hypoxic pulmonary vasoconstriction, and following cardiopulmonary bypass and cardiac transplantation...
- TAMOXIFEN--RISK OF MI, STROKE AND VENOUS THROMBOEMBOLISMLeslie Bernstein; Fiscal Year: 2001..disease and stroke or increases risk of venous thromboembolic events (VTE: deep venous thrombophlebitis and pulmonary embolism) is uncertain. In the U.S...
- INCIDENCE AND OUTCOMES OF VENOUS THROMBOEMBOLISMMARC SILVERSTEIN; Fiscal Year: 1993Deep vein thrombosis (DVT) and pulmonary embolism (PE) most often occur during hospitalization for surgery or chronic medical conditions...