chronic obstructive pulmonary disease

Summary

Summary: A disease of chronic diffuse irreversible airflow obstruction. Subcategories of COPD include CHRONIC BRONCHITIS and PULMONARY EMPHYSEMA.

Top Publications

  1. ncbi Standards for the diagnosis and treatment of patients with COPD: a summary of the ATS/ERS position paper
    B R Celli
    Pulmonary and Critical Care Division, St Elizabeth s Medical Center, Tufts University School of Medicine, Boston, Massachusetts 02135, USA
    Eur Respir J 23:932-46. 2004
  2. pmc A genome-wide association study in chronic obstructive pulmonary disease (COPD): identification of two major susceptibility loci
    Sreekumar G Pillai
    Genetics Division, GlaxoSmithKline Research and Development, Research Triangle Park, NC, USA
    PLoS Genet 5:e1000421. 2009
  3. ncbi Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: GOLD executive summary
    Klaus F Rabe
    Leiden University Medical Center, Pulmonology, P O Box 9600, NL 2300 RC, Leiden, The Netherlands
    Am J Respir Crit Care Med 176:532-55. 2007
  4. ncbi Susceptibility to exacerbation in chronic obstructive pulmonary disease
    John R Hurst
    Academic Unit of Respiratory Medicine, Royal Free Campus, UCL Medical School, London, United Kingdom
    N Engl J Med 363:1128-38. 2010
  5. ncbi The nature of small-airway obstruction in chronic obstructive pulmonary disease
    James C Hogg
    University of British Columbia, the Centre for Cardiovascular and Pulmonary Research, and St Paul s Hospital, Vancouver, Canada
    N Engl J Med 350:2645-53. 2004
  6. ncbi The body-mass index, airflow obstruction, dyspnea, and exercise capacity index in chronic obstructive pulmonary disease
    Bartolome R Celli
    COPD Center at St Elizabeth s Medical Center, Tufts University School of Medicine, Boston, MA 02135, USA
    N Engl J Med 350:1005-12. 2004
  7. ncbi Salmeterol and fluticasone propionate and survival in chronic obstructive pulmonary disease
    Peter M A Calverley
    University Hospital Aintree, Liverpool, United Kingdom
    N Engl J Med 356:775-89. 2007
  8. ncbi A 4-year trial of tiotropium in chronic obstructive pulmonary disease
    Donald P Tashkin
    David Geffen School of Medicine at the University of California, Los Angeles 90095 1690, USA
    N Engl J Med 359:1543-54. 2008
  9. ncbi International variation in the prevalence of COPD (the BOLD Study): a population-based prevalence study
    A Sonia Buist
    Oregon Health and Sciences University, Portland, OR 97239, USA
    Lancet 370:741-50. 2007
  10. ncbi American Thoracic Society/European Respiratory Society statement on pulmonary rehabilitation
    Linda Nici
    Am J Respir Crit Care Med 173:1390-413. 2006

Detail Information

Publications286 found, 100 shown here

  1. ncbi Standards for the diagnosis and treatment of patients with COPD: a summary of the ATS/ERS position paper
    B R Celli
    Pulmonary and Critical Care Division, St Elizabeth s Medical Center, Tufts University School of Medicine, Boston, Massachusetts 02135, USA
    Eur Respir J 23:932-46. 2004
  2. pmc A genome-wide association study in chronic obstructive pulmonary disease (COPD): identification of two major susceptibility loci
    Sreekumar G Pillai
    Genetics Division, GlaxoSmithKline Research and Development, Research Triangle Park, NC, USA
    PLoS Genet 5:e1000421. 2009
    There is considerable variability in the susceptibility of smokers to develop chronic obstructive pulmonary disease (COPD)...
  3. ncbi Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: GOLD executive summary
    Klaus F Rabe
    Leiden University Medical Center, Pulmonology, P O Box 9600, NL 2300 RC, Leiden, The Netherlands
    Am J Respir Crit Care Med 176:532-55. 2007
    b>Chronic obstructive pulmonary disease (COPD) remains a major public health problem...
  4. ncbi Susceptibility to exacerbation in chronic obstructive pulmonary disease
    John R Hurst
    Academic Unit of Respiratory Medicine, Royal Free Campus, UCL Medical School, London, United Kingdom
    N Engl J Med 363:1128-38. 2010
    Although we know that exacerbations are key events in chronic obstructive pulmonary disease (COPD), our understanding of their frequency, determinants, and effects is incomplete...
  5. ncbi The nature of small-airway obstruction in chronic obstructive pulmonary disease
    James C Hogg
    University of British Columbia, the Centre for Cardiovascular and Pulmonary Research, and St Paul s Hospital, Vancouver, Canada
    N Engl J Med 350:2645-53. 2004
    b>Chronic obstructive pulmonary disease (COPD) is a major public health problem associated with long-term exposure to toxic gases and particles...
  6. ncbi The body-mass index, airflow obstruction, dyspnea, and exercise capacity index in chronic obstructive pulmonary disease
    Bartolome R Celli
    COPD Center at St Elizabeth s Medical Center, Tufts University School of Medicine, Boston, MA 02135, USA
    N Engl J Med 350:1005-12. 2004
    b>Chronic obstructive pulmonary disease (COPD) is characterized by an incompletely reversible limitation in airflow. A physiological variable--the forced expiratory volume in one second (FEV1)--is often used to grade the severity of COPD...
  7. ncbi Salmeterol and fluticasone propionate and survival in chronic obstructive pulmonary disease
    Peter M A Calverley
    University Hospital Aintree, Liverpool, United Kingdom
    N Engl J Med 356:775-89. 2007
    Long-acting beta-agonists and inhaled corticosteroids are used to treat chronic obstructive pulmonary disease (COPD), but their effect on survival is unknown.
  8. ncbi A 4-year trial of tiotropium in chronic obstructive pulmonary disease
    Donald P Tashkin
    David Geffen School of Medicine at the University of California, Los Angeles 90095 1690, USA
    N Engl J Med 359:1543-54. 2008
    Previous studies showing that tiotropium improves multiple end points in patients with chronic obstructive pulmonary disease (COPD) led us to examine the long-term effects of tiotropium therapy.
  9. ncbi International variation in the prevalence of COPD (the BOLD Study): a population-based prevalence study
    A Sonia Buist
    Oregon Health and Sciences University, Portland, OR 97239, USA
    Lancet 370:741-50. 2007
    b>Chronic obstructive pulmonary disease (COPD) is a growing cause of morbidity and mortality worldwide, and accurate estimates of the prevalence of this disease are needed to anticipate the future burden of COPD, target key risk factors, ..
  10. ncbi American Thoracic Society/European Respiratory Society statement on pulmonary rehabilitation
    Linda Nici
    Am J Respir Crit Care Med 173:1390-413. 2006
  11. pmc Relationship between exacerbation frequency and lung function decline in chronic obstructive pulmonary disease
    G C Donaldson
    Academic Unit of Respiratory Medicine, St Bartholomew s and Royal London School of Medicine and Dentistry, UK
    Thorax 57:847-52. 2002
    b>Chronic obstructive pulmonary disease (COPD) is characterised by both an accelerated decline in lung function and periods of acute deterioration in symptoms termed exacerbations...
  12. ncbi Global burden of COPD: risk factors, prevalence, and future trends
    David M Mannino
    Department of Preventive Medicine and Environmental Health, University of Kentucky College of Public Health, Lexington, KY 40536, USA
    Lancet 370:765-73. 2007
    b>Chronic obstructive pulmonary disease (COPD) continues to be an important cause of morbidity, mortality, and health-care costs worldwide...
  13. pmc Severe acute exacerbations and mortality in patients with chronic obstructive pulmonary disease
    J J Soler-Cataluña
    Unidad de Neumología, Servicio de Medicina Interna, Hospital General de Requena, Paraje Casablanca s n 46340, Requena Valencia, Spain
    Thorax 60:925-31. 2005
    Patients with chronic obstructive pulmonary disease (COPD) often present with severe acute exacerbations requiring hospital treatment. However, little is known about the prognostic consequences of these exacerbations...
  14. ncbi Global burden of COPD: systematic review and meta-analysis
    R J Halbert
    Center Life Sciences, Beverly Hills, CA 90212, USA
    Eur Respir J 28:523-32. 2006
    The aim of this study was to quantify the global prevalence of chronic obstructive pulmonary disease (COPD) by means of a systematic review and random effects meta-analysis...
  15. ncbi Chronic obstructive pulmonary disease: current burden and future projections
    A D Lopez
    University of Queensland, Brisbane, Australia
    Eur Respir J 27:397-412. 2006
  16. pmc Association between chronic obstructive pulmonary disease and systemic inflammation: a systematic review and a meta-analysis
    W Q Gan
    The James Hogg iCAPTURE Center for Cardiovascular and Pulmonary Research, St Paul s Hospital, Room 368A, 1081 Burrard Street, Vancouver, British Columbia, Canada V6A 1Y6
    Thorax 59:574-80. 2004
    Individuals with chronic obstructive pulmonary disease (COPD) are at increased risk of cardiovascular diseases, osteoporosis, and muscle wasting. Systemic inflammation may be involved in the pathogenesis of these disorders...
  17. pmc Regular physical activity reduces hospital admission and mortality in chronic obstructive pulmonary disease: a population based cohort study
    J Garcia-Aymerich
    Respiratory and Environmental Health Research Unit, Institut Municipal d Investigacio Medica IMIM, Barcelona, Spain
    Thorax 61:772-8. 2006
    Information about the influence of regular physical activity on the course of chronic obstructive pulmonary disease (COPD) is scarce...
  18. ncbi Chronic obstructive pulmonary disease phenotypes: the future of COPD
    MeiLan K Han
    University of Michigan Pulmonary and Critical Care, 1500 E Medical Center Drive, 3916 Taubman, Ann Arbor, MI 48109, USA
    Am J Respir Crit Care Med 182:598-604. 2010
    Significant heterogeneity of clinical presentation and disease progression exists within chronic obstructive pulmonary disease (COPD). Although FEV(1) inadequately describes this heterogeneity, a clear alternative has not emerged...
  19. ncbi Chronic obstructive pulmonary disease in non-smokers
    Sundeep S Salvi
    Chest Research Foundation, Pune, India
    Lancet 374:733-43. 2009
    b>Chronic obstructive pulmonary disease (COPD) is a leading cause of morbidity and mortality worldwide...
  20. ncbi Characteristics of physical activities in daily life in chronic obstructive pulmonary disease
    Fabio Pitta
    Respiratory Rehabilitation and Respiratory Division, University Hospital Gasthuisberg, Herestraat 49, B 3000 Leuven, Belgium
    Am J Respir Crit Care Med 171:972-7. 2005
    Quantification of physical activities in daily life in patients with chronic obstructive pulmonary disease has increasing clinical interest. However, detailed comparison with healthy subjects is not available...
  21. ncbi Once-daily bronchodilators for chronic obstructive pulmonary disease: indacaterol versus tiotropium
    James F Donohue
    University of North Carolina, 4125 Bioinformatics Building, 130 Mason Farm Road, CB 7020, Chapel Hill, NC, USA
    Am J Respir Crit Care Med 182:155-62. 2010
    Indacaterol is the first once-daily, long-acting inhaled beta(2)-agonist bronchodilator studied in patients with chronic obstructive pulmonary disease (COPD).
  22. pmc Development, validity and responsiveness of the Clinical COPD Questionnaire
    Thys van der Molen
    Department of General Practice, University of Groningen, Groningen, The Netherlands
    Health Qual Life Outcomes 1:13. 2003
    The new Global Obstructive Lung Disease (GOLD) guidelines advice to focus treatment in Chronic Obstructive Pulmonary Disease (COPD) on improvement of functional state, prevention of disease progression and minimization of symptoms...
  23. ncbi Infections and airway inflammation in chronic obstructive pulmonary disease severe exacerbations
    Alberto Papi
    Research Center on Asthma and COPD, Department of Respiratory Diseases, University of Modena and Reggio Emilia, Via del Pozzo 71, I 41100 Modena, Italy
    Am J Respir Crit Care Med 173:1114-21. 2006
    Severe exacerbations of chronic obstructive pulmonary disease (COPD) are major causes of health care costs mostly related to hospitalization. The role of infections in COPD exacerbations is controversial.
  24. ncbi Pulmonary Rehabilitation: Joint ACCP/AACVPR Evidence-Based Clinical Practice Guidelines
    Andrew L Ries
    University of California, San Diego, Department of Pulmonary and Critical Care Medicine, UCSD Medical Center, 200 West Arbor Dr, San Diego, CA 92103 8377, USA
    Chest 131:4S-42S. 2007
    ....
  25. ncbi Burden and clinical features of chronic obstructive pulmonary disease (COPD)
    Romain A Pauwels
    Department of Respiratory Diseases, Ghent University Hospital, Ghent, Belgium
    Lancet 364:613-20. 2004
    b>Chronic obstructive pulmonary disease (COPD) is a major cause of chronic morbidity and mortality and represents a substantial economic and social burden throughout the world...
  26. ncbi Chronic obstructive pulmonary disease in five Latin American cities (the PLATINO study): a prevalence study
    Ana Maria B Menezes
    Universidade Federal de Pelotas, Pelotas, Brazil
    Lancet 366:1875-81. 2005
    Both the prevalence and mortality attributable to chronic obstructive pulmonary disease (COPD) seem to be increasing in low-income and middle-income countries, but few data are available...
  27. ncbi Respiratory viruses, symptoms, and inflammatory markers in acute exacerbations and stable chronic obstructive pulmonary disease
    T Seemungal
    Academic Department of Respiratory Medicine and Virology, St. Bartholomew's and Royal London School of Medicine and Dentistry, London, UK
    Am J Respir Crit Care Med 164:1618-23. 2001
    The effects of respiratory viral infection on the time course of chronic obstructive pulmonary disease (COPD) exacerbation were examined by monitoring changes in systemic inflammatory markers in stable COPD and at exacerbation...
  28. ncbi Outcomes for COPD pharmacological trials: from lung function to biomarkers
    M Cazzola
    Unit of Respiratory Diseases, Dept of Internal Medicine, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, Italy
    Eur Respir J 31:416-69. 2008
    ..on "Outcomes for COPD pharmacological trials: from lung function to biomarkers" to inform the chronic obstructive pulmonary disease research community about the possible use and limitations of current outcomes and markers when ..
  29. ncbi Effect of pharmacotherapy on rate of decline of lung function in chronic obstructive pulmonary disease: results from the TORCH study
    Bartolome R Celli
    Tufts University School of Medicine, Pulmonary and Critical Care Division, Caritas St Elizabeth s Medical Center, Boston, MA 02135 2997, USA
    Am J Respir Crit Care Med 178:332-8. 2008
    b>Chronic obstructive pulmonary disease (COPD) is characterized by an accelerated decline in lung function. No drug has been shown conclusively to reduce this decline.
  30. ncbi Prevalence of chronic obstructive pulmonary disease in China: a large, population-based survey
    Nanshan Zhong
    Guangzhou Institute of Respiratory Diseases, The First Affiliated Hospital, Guangzhou Medical College, 151 Yanjiang Road, Guangzhou, Guangdong 510120, China
    Am J Respir Crit Care Med 176:753-60. 2007
    The prevalence of chronic obstructive pulmonary disease (COPD) in China is largely unknown.
  31. ncbi Immunology of asthma and chronic obstructive pulmonary disease
    Peter J Barnes
    Airway Disease Section, National Heart and Lung Institute, Imperial College London, Dovehouse Street, London SW3 6LY, UK
    Nat Rev Immunol 8:183-92. 2008
    Asthma and chronic obstructive pulmonary disease (COPD) are both obstructive airway diseases that involve chronic inflammation of the respiratory tract, but the type of inflammation is markedly different between these diseases, with ..
  32. ncbi Patient adherence in COPD
    J Bourbeau
    Montreal Chest Institute, McGill University Health Centre, 3650 St Urbain, Office K1 30, Montreal, Quebec
    Thorax 63:831-8. 2008
    Patient adherence to treatment in chronic obstructive pulmonary disease (COPD) is essential to optimise disease management...
  33. ncbi Effect of tiotropium on outcomes in patients with moderate chronic obstructive pulmonary disease (UPLIFT): a prespecified subgroup analysis of a randomised controlled trial
    Marc Decramer
    Respiratory Division, University of Leuven, Leuven, Belgium
    Lancet 374:1171-8. 2009
    The beneficial effects of pharmacotherapy for chronic obstructive pulmonary disease (COPD) are well established. However, there are few data for treatment in the early stages of the disease...
  34. ncbi Roflumilast in symptomatic chronic obstructive pulmonary disease: two randomised clinical trials
    Peter M A Calverley
    School of Clinical Sciences, Liverpool, UK
    Lancet 374:685-94. 2009
    ..inhibitor roflumilast can improve lung function and prevent exacerbations in certain patients with chronic obstructive pulmonary disease (COPD)...
  35. ncbi Glucocorticoid resistance in inflammatory diseases
    Peter J Barnes
    National Heart and Lung Institute, Imperial College, London, UK
    Lancet 373:1905-17. 2009
    ..is a major barrier to the treatment of several common inflammatory diseases-including chronic obstructive pulmonary disease and acute respiratory distress syndrome; it is also an issue for some patients with asthma, ..
  36. ncbi Depressive symptoms and chronic obstructive pulmonary disease: effect on mortality, hospital readmission, symptom burden, functional status, and quality of life
    Tze Pin Ng
    Gerontological Research Programme, Faculty of Medicine, National University of Singapore, Singapore
    Arch Intern Med 167:60-7. 2007
    Depressive symptoms are common among patients with chronic obstructive pulmonary disease (COPD), but depression's impact on COPD outcomes has not been fully investigated...
  37. pmc Variants in FAM13A are associated with chronic obstructive pulmonary disease
    Michael H Cho
    Channing Laboratory, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Nat Genet 42:200-2. 2010
    We performed a genome-wide association study for chronic obstructive pulmonary disease (COPD) in three population cohorts, including 2,940 cases and 1,380 controls who were current or former smokers with normal lung function...
  38. ncbi Mortality in COPD: Role of comorbidities
    D D Sin
    The James Hogg iCAPTURE Center for Cardiovascular and Pulmonary Research, St Paul s Hospital, 1081 Burrard Street, Vancouver, BC, Canada
    Eur Respir J 28:1245-57. 2006
    b>Chronic obstructive pulmonary disease (COPD) represents an increasing burden throughout the world. COPD-related mortality is probably underestimated because of the difficulties associated with identifying the precise cause of death...
  39. ncbi Airway and systemic inflammation and decline in lung function in patients with COPD
    Gavin C Donaldson
    Academic Unit of Respiratory Medicine, St Bartholomew s and Royal London Hospital School of Medicine and Dentistry, London, UK
    Chest 128:1995-2004. 2005
    ..Patients with COPD experience lower airway and systemic inflammation, and an accelerated decline in FEV1. There is no evidence on whether this inflammation changes over time, or if it is associated with a faster decline in FEV1...
  40. ncbi Systematic review of the chronic care model in chronic obstructive pulmonary disease prevention and management
    Sandra G Adams
    Department of Medicine, The University of Texas Health Science Center at San Antonio, USA
    Arch Intern Med 167:551-61. 2007
    ..to improve outcomes in diabetes mellitus, depression, and congestive heart failure, but data are lacking regarding the effectiveness of this model in preventing complications in patients with chronic obstructive pulmonary disease.
  41. ncbi Definition, epidemiology and natural history of COPD
    G Viegi
    CNR Institute of Clinical Physiology, Via Trieste 41, 56126, Pisa, Italy
    Eur Respir J 30:993-1013. 2007
    b>Chronic obstructive pulmonary disease (COPD) is the fifth cause of morbidity and mortality in the developed world and represents a substantial economic and social burden...
  42. ncbi The cytokine network in chronic obstructive pulmonary disease
    Peter J Barnes
    National Heart and Lung Institute, Imperial College London, London, United Kingdom
    Am J Respir Cell Mol Biol 41:631-8. 2009
    ..play a role in the orchestration of inflammation in inflammatory airway diseases, such as chronic obstructive pulmonary disease, through the recruitment, activation and survival of inflammatory cells...
  43. ncbi Smoking alters alveolar macrophage recognition and phagocytic ability: implications in chronic obstructive pulmonary disease
    Sandra Hodge
    Department of Thoracic Medicine, Royal Adelaide Hospital and Lung Research Laboratory, Hanson Institute, Adelaide, South Australia
    Am J Respir Cell Mol Biol 37:748-55. 2007
    b>Chronic obstructive pulmonary disease (COPD) is associated with defective efferocytosis (apoptosis and alveolar macrophage [AM] phagocytic function) that may lead to secondary necrosis and tissue damage...
  44. ncbi Respiratory syncytial virus infection in elderly and high-risk adults
    Ann R Falsey
    Department of Medicine, Rochester General Hospital, Rochester, NY 14621, USA
    N Engl J Med 352:1749-59. 2005
    ..Data on the epidemiology and clinical effects in community-dwelling elderly persons and high-risk adults can help in assessing the need for vaccine development...
  45. ncbi Evaluation of COPD Longitudinally to Identify Predictive Surrogate End-points (ECLIPSE)
    J Vestbo
    Hvidovre Hospital, University of Copenhagen, Hvidovre, Denmark
    Eur Respir J 31:869-73. 2008
    b>Chronic obstructive pulmonary disease (COPD) is a heterogeneous disease and not well understood...
  46. pmc Relationship between bacterial colonisation and the frequency, character, and severity of COPD exacerbations
    I S Patel
    Academic Respiratory Medicine, St Bartholomew s and Royal London School of Medicine and Dentistry, London EC1A 7BE, UK
    Thorax 57:759-64. 2002
    Patients with chronic obstructive pulmonary disease (COPD) are prone to frequent exacerbations which are a significant cause of morbidity and mortality...
  47. pmc Developing COPD: a 25 year follow up study of the general population
    A Løkke
    Department of Cardiology and Respiratory Medicine, 253 Hvidovre Hospital, Kettegard Alle 30, DK 2650 Hvidovre, Denmark
    Thorax 61:935-9. 2006
    Smokers are more prone to develop chronic obstructive pulmonary disease (COPD) than non-smokers, but this finding comes from studies spanning 10 years or less...
  48. ncbi Inhaled corticosteroid use in chronic obstructive pulmonary disease and the risk of hospitalization for pneumonia
    Pierre Ernst
    Pharmacoepidemiology Research Unit, Department of Medicine, McGill University Health Centre, and Division of Clinical Epidemiology, Ross 4 29, Royal Victoria Hospital, 687 Pine Avenue West, Montreal, PQ, Quebec, H3A 1A1 Canada
    Am J Respir Crit Care Med 176:162-6. 2007
    Inhaled corticosteroids are commonly prescribed to patients with chronic obstructive pulmonary disease (COPD).
  49. pmc Tai chi exercise for patients with chronic obstructive pulmonary disease: a pilot study
    Gloria Y Yeh
    Division for Research and Education in Complementary and Integrative Medical Therapies, Osher Research Center, Harvard Medical School, 401 Park Drive, Suite 22A, Boston, MA 02215, USA
    Respir Care 55:1475-82. 2010
    ..To determine the feasibility of a randomized controlled trial of the effect of a tai chi program on quality of life and exercise capacity in patients with COPD...
  50. pmc The cytokine network in asthma and chronic obstructive pulmonary disease
    Peter J Barnes
    National Heart and Lung Institute, Imperial College London, London, UK
    J Clin Invest 118:3546-56. 2008
    Asthma and chronic obstructive pulmonary disease (COPD) are very common inflammatory diseases of the airways. They both cause airway narrowing and are increasing in incidence throughout the world, imposing enormous burdens on health care...
  51. ncbi Anxiety and depression in patients with chronic obstructive pulmonary disease (COPD). A review
    Rie Lambaek Mikkelsen
    Psychiatric Center Gentofte, Niels Andersens, Hellerup, Denmark
    Nord J Psychiatry 58:65-70. 2004
    A review of the literature revealed high comorbidity of chronic obstructive pulmonary disease (COPD) and states of anxiety and depression, indicative of excess, psychiatric morbidity in COPD...
  52. ncbi Chronic obstructive pulmonary disease and hospitalizations for pneumonia in a US cohort
    David M Mannino
    Department of Preventive Medicine and Environmental Health, University of Kentucky College of Public Health, 121 Washington Avenue, Lexington, KY 40536, USA
    Respir Med 103:224-9. 2009
    ..To better understand risk factors for pneumonia hospitalizations in people with impaired lung function...
  53. ncbi Roflumilast in moderate-to-severe chronic obstructive pulmonary disease treated with longacting bronchodilators: two randomised clinical trials
    Leonardo M Fabbri
    University of Modena and Reggio Emilia, Modena, Italy
    Lancet 374:695-703. 2009
    Patients with chronic obstructive pulmonary disease (COPD) have few options for treatment...
  54. pmc COPD exacerbations .1: Epidemiology
    G C Donaldson
    Academic Unit of Respiratory Medicine, University College London, UK
    Thorax 61:164-8. 2006
    The epidemiology of exacerbations of chronic obstructive pulmonary disease (COPD) is reviewed with particular reference to the definition, frequency, time course, natural history and seasonality, and their relationship with decline in ..
  55. ncbi Derivation and validation of a composite index of severity in chronic obstructive pulmonary disease: the DOSE Index
    Rupert C Jones
    Respiratory Research Unit, Peninsula Medical School, University of Plymouth, Devon, UK
    Am J Respir Crit Care Med 180:1189-95. 2009
    b>Chronic obstructive pulmonary disease (COPD) is increasingly recognized as a multicomponent disease with systemic consequences and effects on quality of life...
  56. ncbi The preclinical pharmacology of roflumilast--a selective, oral phosphodiesterase 4 inhibitor in development for chronic obstructive pulmonary disease
    Armin Hatzelmann
    Nycomed GmbH, Konstanz, Germany
    Pulm Pharmacol Ther 23:235-56. 2010
    ..To further understand its functional mode of action in chronic obstructive pulmonary disease (COPD), for which roflumilast is being developed, a series of in vitro and in vivo preclinical ..
  57. ncbi Extrapulmonary effects of chronic obstructive pulmonary disease on physical activity: a cross-sectional study
    Henrik Watz
    Pulmonary Research Institute at Hospital Grosshansdorf, Center for Pneumology and Thoracic Surgery, Woehrendamm 80, D 22927 Grosshansdorf, Germany
    Am J Respir Crit Care Med 177:743-51. 2008
    Physical activity is reduced in patients with chronic obstructive pulmonary disease (COPD). COPD has a systemic component that includes significant extrapulmonary effects that may contribute to its severity in individual patients.
  58. ncbi Dyspnea is a better predictor of 5-year survival than airway obstruction in patients with COPD
    Koichi Nishimura
    Respiratory Division, Kyoto Katsura Hospital, Kyoto, Japan
    Chest 121:1434-40. 2002
    ....
  59. ncbi Mortality after hospitalization for COPD
    Pedro Almagro
    Internal Medicine, Hospital Mutua de Terrassa, University of Barcelona, Barcelona, Spain
    Chest 121:1441-8. 2002
    ..To identify variables associated with mortality in patients admitted to the hospital for acute exacerbation of COPD...
  60. ncbi Cardiovascular disease in patients with chronic obstructive pulmonary disease, Saskatchewan Canada cardiovascular disease in COPD patients
    Suellen M Curkendall
    Cerner Health Insights, Vienna, VA 22182, USA
    Ann Epidemiol 16:63-70. 2006
    To measure prevalence, incidence, and mortality of cardiovascular outcomes among persons with chronic obstructive pulmonary disease (COPD) and to assess the extent these outcomes differ from persons without COPD.
  61. ncbi The 6-min walk distance: change over time and value as a predictor of survival in severe COPD
    V M Pinto-Plata
    Division of Pulmonary and Critical Care Medicine, St Elizabeth s Medical Center, Tufts University School of Medicine, Boston, MA 02135, USA
    Eur Respir J 23:28-33. 2004
    The 6-min walk distance (6MWD) is used to evaluate the functional capacity of patients with chronic obstructive pulmonary disease (COPD)...
  62. ncbi Obstructive and restrictive lung disease and markers of inflammation: data from the Third National Health and Nutrition Examination
    David M Mannino
    Air Pollution and Respiratory Health Branch, Division of Environmental Hazards and Health Effects, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Am J Med 114:758-62. 2003
  63. ncbi Mediators of chronic obstructive pulmonary disease
    Peter J Barnes
    National Heart and Lung Institute, Imperial College School of Medicine, Dovehouse St, London SW3 6LY, United Kingdom
    Pharmacol Rev 56:515-48. 2004
    b>Chronic obstructive pulmonary disease (COPD) is a major and increasing global health problem that is now a leading cause of death...
  64. pmc Efficacy of salmeterol/fluticasone propionate by GOLD stage of chronic obstructive pulmonary disease: analysis from the randomised, placebo-controlled TORCH study
    Christine R Jenkins
    Woolcock Institute of Medical Research, Sydney, Australia
    Respir Res 10:59. 2009
    ..However, there are only limited data about the influence of GOLD severity staging on the effectiveness of SFC, particularly in patients with milder disease...
  65. ncbi Body composition and mortality in chronic obstructive pulmonary disease
    Annemie M W J Schols
    Department of Respiratory Medicine, University of Maastricht, Maastricht, Netherlands
    Am J Clin Nutr 82:53-9. 2005
    Survival studies have consistently shown significantly greater mortality rates in underweight and normal-weight patients with chronic obstructive pulmonary disease (COPD) than in overweight and obese COPD patients.
  66. pmc Prevalence, diagnosis and relation to tobacco dependence of chronic obstructive pulmonary disease in a nationally representative population sample
    L Shahab
    Cancer Research Health Behaviour Unit, Department of Epidemiology and Public Health, University College London, London WC1E 6BT, UK
    Thorax 61:1043-7. 2006
    b>Chronic obstructive pulmonary disease (COPD) is the fourth most common cause of death worldwide. It is caused primarily by cigarette smoking...
  67. pmc Risk factors of readmission to hospital for a COPD exacerbation: a prospective study
    J Garcia-Aymerich
    Respiratory and Environmental Health Research Unit, IMIM, Barcelona, Spain
    Thorax 58:100-5. 2003
    Exacerbations of chronic obstructive pulmonary disease (COPD) are a leading cause of admission to hospital among men in many countries, although the factors causing exacerbations are largely unknown...
  68. ncbi Epidemiology and costs of chronic obstructive pulmonary disease
    K R Chapman
    Asthma and Airway Centre, Toronto University Health Network, Toronto Western Hospital, Room 7 451 New East Wing, 399 Bathurst Street, Toronto, Ontario M5T 2S8, Canada
    Eur Respir J 27:188-207. 2006
  69. ncbi Increased airway epithelial and T-cell apoptosis in COPD remains despite smoking cessation
    S Hodge
    Dept of Thoracic Medicine, Royal Adelaide Hospital and Hanson Institute, Adelaide, South Australia 5001, Australia
    Eur Respir J 25:447-54. 2005
    There is heterogeneity in the propensity of smokers to develop chronic obstructive pulmonary disease (COPD), and improved treatment strategies are hindered by limited understanding of COPD pathogenesis, especially as distinct from the ..
  70. ncbi Pathophysiology of airflow limitation in chronic obstructive pulmonary disease
    James C Hogg
    James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, University of British Columbia and St Paul s Hospital, Room 166 1081, Burrard Street, Vancouver, BC V6Z 1Y6, Canada
    Lancet 364:709-21. 2004
    The airflow limitation that defines chronic obstructive pulmonary disease (COPD) is the result of a prolonged time constant for lung emptying, caused by increased resistance of the small conducting airways and increased compliance of the ..
  71. ncbi Patient insight into the impact of chronic obstructive pulmonary disease in the morning: an internet survey
    Martyn R Partridge
    Imperial College London, NHLI Division, Charing Cross Hospital, London W6 8RP, UK
    Curr Med Res Opin 25:2043-8. 2009
    To determine diurnal variability of symptoms in chronic obstructive pulmonary disease (COPD) and to assess the impact of COPD upon patients' morning activities and routines.
  72. ncbi Molecular mechanisms of oxidative stress in airways and lungs with reference to asthma and chronic obstructive pulmonary disease
    K F Chung
    National Heart and Lung Institute, Imperial College, MRC Asthma UK Centre for Allergic Mechanisms in Asthma and Biomedical Research Unit, Royal Brompton Hospital, London, UK
    Ann N Y Acad Sci 1203:85-91. 2010
    Oxidative stress is an important pathophysiological component of airway diseases such as asthma and chronic obstructive pulmonary disease (COPD), which cause significant morbidity and mortality...
  73. ncbi Quantitative assessment of bronchial wall attenuation with thin-section CT: An indicator of airflow limitation in chronic obstructive pulmonary disease
    Tsuneo Yamashiro
    Center for Pulmonary Functional Imaging, Brigham and Women s Hospital, Boston, MA, USA
    AJR Am J Roentgenol 195:363-9. 2010
    The purpose of this study was to evaluate the relation between bronchial wall attenuation on thin-section CT images and airflow limitation in persons with chronic obstructive pulmonary disease.
  74. ncbi Polymorphisms in IL13 pathway genes in asthma and chronic obstructive pulmonary disease
    B Beghe
    Department of Oncology, Haematology and Respiratory Diseases, University of Modena and Reggio Emilia, Italy
    Allergy 65:474-81. 2010
    Asthma and chronic obstructive pulmonary disease (COPD) are chronic respiratory diseases involving an interaction between genetic and environmental factors. Interleukin-13 (IL13) has been suggested to have a role in both asthma and COPD...
  75. pmc Egr-1 regulates autophagy in cigarette smoke-induced chronic obstructive pulmonary disease
    Zhi Hua Chen
    Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    PLoS ONE 3:e3316. 2008
    b>Chronic obstructive pulmonary disease (COPD) is a progressive lung disease characterized by abnormal cellular responses to cigarette smoke, resulting in tissue destruction and airflow limitation...
  76. ncbi Home telehealth for chronic obstructive pulmonary disease: a systematic review and meta-analysis
    Julie Polisena
    Canadian Agency for Drugs and Technologies in Health CADTH, Ottawa, Ontario, Canada
    J Telemed Telecare 16:120-7. 2010
    We conducted a systematic review of the literature about home telehealth for chronic obstructive pulmonary disease (COPD) compared with usual care. An electronic literature search identified 6241 citations...
  77. ncbi Quantitative assessment of air trapping in chronic obstructive pulmonary disease using inspiratory and expiratory volumetric MDCT
    Shin Matsuoka
    Department of Radiology, St Marianna University School of Medicine, 2 16 1 Sugao, Miyamae ku, Kawasaki City, Kanagawa 216 8511, Japan
    AJR Am J Roentgenol 190:762-9. 2008
    ..and expiratory volumetric MDCT scans and to assess whether the densitometric parameter can be used for the quantification of airway dysfunction in chronic obstructive pulmonary disease (COPD) regardless of the degree of emphysema.
  78. pmc Persistent activation of an innate immune response translates respiratory viral infection into chronic lung disease
    Edy Y Kim
    Department of Medicine, 660 South Euclid Avenue, St Louis, Missouri 63110, USA
    Nat Med 14:633-40. 2008
    ..an experimental mouse model of chronic lung disease with pathology that resembles asthma and chronic obstructive pulmonary disease (COPD) in humans...
  79. pmc Efficacy and tolerability of budesonide/formoterol in one hydrofluoroalkane pressurized metered-dose inhaler in patients with chronic obstructive pulmonary disease: results from a 1-year randomized controlled clinical trial
    Stephen I Rennard
    Pulmonary Critical Care, Allergy and Sleep Medicine, University of Nebraska Medical Center, Omaha, Nebraska 68198 5885, USA
    Drugs 69:549-65. 2009
    ..a long-acting bronchodilator and an inhaled corticosteroid (ICS) is recommended in patients with chronic obstructive pulmonary disease (COPD) who have frequent exacerbations...
  80. ncbi The 15q24/25 susceptibility variant for lung cancer and chronic obstructive pulmonary disease is associated with emphysema
    Diether Lambrechts
    Vesalius Research Center, K U Leuven, Leuven, Belgium
    Am J Respir Crit Care Med 181:486-93. 2010
    ..receptor (nAChR) on chromosome 15q24/25 as a risk for nicotine dependence, lung cancer, and chronic obstructive pulmonary disease (COPD)...
  81. ncbi Efficacy and safety of budesonide and formoterol in one pressurized metered-dose inhaler in patients with moderate to very severe chronic obstructive pulmonary disease: results of a 6-month randomized clinical trial
    Donald P Tashkin
    Division of Pulmonary and Critical Care Medicine, University of California, Los Angeles, California, USA
    Drugs 68:1975-2000. 2008
    ..ICS) and a long-acting bronchodilator is recommended in the treatment of patients with chronic obstructive pulmonary disease (COPD) who have frequent exacerbations...
  82. ncbi Patterns of comorbidities in newly diagnosed COPD and asthma in primary care
    Joan B Soriano
    Worldwide Epidemiology and Global Clinical Safety and Pharmacovigilance, GlaxoSithKline R and D, Upper Providence, PA, USA
    Chest 128:2099-107. 2005
    ..We aimed to quantify baseline rates of comorbidities in COPD and asthma patients and to compare the risks to the general population...
  83. ncbi COPD exacerbations: defining their cause and prevention
    Jadwiga A Wedzicha
    Academic Unit of Respiratory Medicine, Royal Free and University College Medical School University College London, UK
    Lancet 370:786-96. 2007
    Exacerbations of chronic obstructive pulmonary disease (COPD) are episodes of worsening of symptoms, leading to substantial morbidity and mortality...
  84. ncbi Screening for and early detection of chronic obstructive pulmonary disease
    Joan B Soriano
    CIMERA International Center for Advanced Respiratory Medicine, Recinte Hospital Joan March, Bunyola, Spain
    Lancet 374:721-32. 2009
    b>Chronic obstructive pulmonary disease (COPD) is a substantially underdiagnosed disorder, with the diagnosis typically missed or delayed until the condition is advanced...
  85. pmc Increased cytokine response of rhinovirus-infected airway epithelial cells in chronic obstructive pulmonary disease
    Dina Schneider
    University of Michigan, Ann Arbor, MI 48109 5688, USA
    Am J Respir Crit Care Med 182:332-40. 2010
    Airway inflammation is a central feature of chronic obstructive pulmonary disease (COPD). COPD exacerbations are often triggered by rhinovirus (RV) infection.
  86. pmc SIRT1, an antiinflammatory and antiaging protein, is decreased in lungs of patients with chronic obstructive pulmonary disease
    Saravanan Rajendrasozhan
    Department of Environmental Medicine, University of Rochester Medical Center, Box 850, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Am J Respir Crit Care Med 177:861-70. 2008
    Abnormal inflammation and accelerated decline in lung function occur in patients with chronic obstructive pulmonary disease (COPD)...
  87. ncbi St. George's Respiratory Questionnaire: MCID
    Paul W Jones
    St George s Hospital Medical School, London, UK
    COPD 2:75-9. 2005
    ....
  88. pmc MMP12, lung function, and COPD in high-risk populations
    Gary M Hunninghake
    Channing Laboratory and Center for Genomic Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    N Engl J Med 361:2599-608. 2009
    Genetic variants influencing lung function in children and adults may ultimately lead to the development of chronic obstructive pulmonary disease (COPD), particularly in high-risk groups.
  89. pmc Profiling serum biomarkers in patients with COPD: associations with clinical parameters
    Victor Pinto-Plata
    Caritas St Elizabeth s Medical Center, 736 Cambridge Street, Boston, Massachusetts 02135, USA
    Thorax 62:595-601. 2007
    b>Chronic obstructive pulmonary disease (COPD) is an inflammatory lung disease associated with significant systemic consequences...
  90. ncbi Airway wall thickening and emphysema show independent familial aggregation in chronic obstructive pulmonary disease
    Bipen D Patel
    Department of Medicine, University of Cambridge, Cambridge, UK
    Am J Respir Crit Care Med 178:500-5. 2008
    It is unclear whether airway wall thickening and emphysema make independent contributions to airflow limitation in chronic obstructive pulmonary disease (COPD) and whether these phenotypes cluster within families.
  91. ncbi Systemic inflammation in chronic obstructive pulmonary disease: the role of exacerbations
    Emiel F M Wouters
    Department of Respiratory Medicine, University Hospital Maastricht, P O Box 5800, 6202 AZ Maastricht, The Netherlands
    Proc Am Thorac Soc 4:626-34. 2007
    The systemic manifestations of chronic obstructive pulmonary disease (COPD) exacerbations are recognized, but our understanding of their etiology and importance is lacking largely due to the small number of systematic and longitudinal ..
  92. ncbi Genomic copy number determines functional expression of {beta}-defensin 2 in airway epithelial cells and associates with chronic obstructive pulmonary disease
    Wim Janssens
    Department of Human Genetics, Katholieke Universiteit Leuven, Gasthuisberg O and N1 602, Herestraat 49, B 3000, Leuven, Belgium
    Am J Respir Crit Care Med 182:163-9. 2010
    ..Controversy still exists on whether the beta-defensins genes determine susceptibility for chronic obstructive pulmonary disease (COPD).
  93. ncbi COPD and incident cardiovascular disease hospitalizations and mortality: Kaiser Permanente Medical Care Program
    Stephen Sidney
    Division of Research, Kaiser Permanente Medical Care Program, Kaiser Permanente Northern California, 2000 Broadway, Oakland, CA 94612, USA
    Chest 128:2068-75. 2005
    ..To determine the relationship between diagnosed and treated COPD and the incidence of cardiovascular disease (CVD) hospitalization and mortality...
  94. pmc Glucocorticoid sensitivity of lipopolysaccharide-stimulated chronic obstructive pulmonary disease alveolar macrophages
    J Armstrong
    University of Manchester, NIHR Translational Research Facility, University Hospital of South Manchester Foundation Trust, Manchester, UK
    Clin Exp Immunol 158:74-83. 2009
    It has been reported that alveolar macrophages from patients with chronic obstructive pulmonary disease (COPD) display glucocorticoid (Gc) resistance. The Gc sensitivity of inflammatory mediators released by COPD macrophages may vary...
  95. ncbi Impact of COPD in North America and Europe in 2000: subjects' perspective of Confronting COPD International Survey
    S Rennard
    University of Nebraska, Pulmonary and Critical Care Medicine Section, Omaha 68198 5125, USA
    Eur Respir J 20:799-805. 2002
    To date, no international surveys estimating the burden of chronic obstructive pulmonary disease (COPD) in the general population have been published...
  96. ncbi Risk of over-diagnosis of COPD in asymptomatic elderly never-smokers
    J A Hardie
    Institute of Internal Medicine, Deaconess Hospital, University of Bergen, Norway
    Eur Respir J 20:1117-22. 2002
    The Global Initiative for Chronic Obstructive Lung Disease (GOLD) has defined stage I chronic obstructive pulmonary disease (COPD) as forced expiratory volume in one second/forced vital capacity (FEV1/FVC)% <70% and a FEV1% predicted ..
  97. ncbi Cellular markers of muscle atrophy in chronic obstructive pulmonary disease
    Pamela J Plant
    Department of Medicine, University of Toronto, Toronto, Ontario, Canada
    Am J Respir Cell Mol Biol 42:461-71. 2010
    Skeletal muscle atrophy in individuals with advanced chronic obstructive pulmonary disease (COPD) is associated with diminished quality of life, increased health resource use, and worsened survival...
  98. ncbi Longitudinal study of airway dimensions in chronic obstructive pulmonary disease using computed tomography
    Tadashi Ohara
    Department of Respiratory Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    Respirology 13:372-8. 2008
    ..The objective of this study was to investigate the annual changes in airway dimensions and lung attenuation using CT in patients with COPD and to evaluate the correlations among annual changes in CT measurements and pulmonary function...
  99. ncbi The pathology of chronic obstructive pulmonary disease
    James C Hogg
    Department of Pathology and Laboratory Medicine, University of British Columbia and iCapture Center, St Paul s Hospital, Vancouver, BC, Canada
    Annu Rev Pathol 4:435-59. 2009
    The pathogenesis of chronic obstructive pulmonary disease (COPD) is based on the innate and adaptive inflammatory immune response to the inhalation of toxic particles and gases...
  100. ncbi Temporal clustering of exacerbations in chronic obstructive pulmonary disease
    John R Hurst
    Academic Unit of Respiratory Medicine, Royal Free and University College Medical School, London, United Kingdom
    Am J Respir Crit Care Med 179:369-74. 2009
    Exacerbations are important events in chronic obstructive pulmonary disease. Preventing exacerbations is a key treatment goal...
  101. ncbi COPD as a disease of accelerated lung aging
    Kazuhiro Ito
    National Heart and Lung Institute, Imperial College School of Medicine, London, UK
    Chest 135:173-80. 2009
    ..Recent studies of the signal transduction mechanisms, such as protein acetylation pathways involved in aging, have identified novel antiaging molecules that may provide a new therapeutic approach to COPD...

Research Grants76

  1. Regulation of mural cells during pulmonary capillary formation
    Stephen E McGowan; Fiscal Year: 2013
    ..PUBLIC HEALTH RELEVANCE: PROJECT NARRATIVE: Although the prevalence of smoking has declined, chronic obstructive pulmonary disease (COPD) and its attendant pathological pulmonary abnormality, emphysema, are common and ..
  2. Novel Peptide MPO Inhibitors for Treating Atherosclerosis
    Kirkwood A Pritchard; Fiscal Year: 2012
    ..disease, multiple sclerosis, inflammatory bowel disease, kidney disease, rheumatoid arthritis and chronic obstructive pulmonary disease, where aberrant MPO activity has been implicated...
  3. Global regulatory interactions in bacterial pathogenesis
    BRIAN AKERLEY; Fiscal Year: 2009
    ..spread to other sites frequently causes disease including otitis media, exacerbations of chronic obstructive pulmonary disease, and community acquired pneumonia...
  4. Small Molecule targeting of NADPH oxidase in neutrophils
    Marie Dominique Filippi; Fiscal Year: 2010
    ..ARDS, ALI (and other airway diseases including the Chronic Obstructive Pulmonary Disease (COPD)) are associated with neutrophil infiltration of the airway wall...
  5. Regulation of Innate and Adaptive Immunity in Human COPD and Emphysema
    Farrah Kheradmand; Fiscal Year: 2012
    ..are either current or former smokers which puts this group at a very high risk for developing chronic obstructive pulmonary disease (COPD) and emphysema...
  6. Unbiased genome-wide screen to identify genes regulating mucous cell hyperplasia
    Jeffrey A Whitsett; Fiscal Year: 2010
    ..to the pathogenesis of common pulmonary diseases, including asthma, cystic fibrosis (CF), and chronic obstructive pulmonary disease (COPD)...
  7. Targeting AP-1 proteins in COPD
    SEKHAR M POTHIREDDY; Fiscal Year: 2010
    b>Chronic obstructive pulmonary disease (COPD) is emerging as a major leading cause of morbidity and mortality in the United States and other countries...
  8. Endotoxin, the airway transcriptome, and obstructive lung disease
    PEGGY SUE LAI; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Research Asthma and chronic obstructive pulmonary disease (COPD) are chronic inflammatory lung diseases that affect an estimated 35 million Americans...
  9. Mechanism Underlying Nitrite Sensitivity of Mucoid Pseudomonas in COPD
    Daniel J Hassett; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Nearly 40% of Cincinnati VA patients suffer from chronic obstructive pulmonary disease (COPD) that often suffer from airway infection by opportunistic bacteria, the most prevalent of which is ..
  10. ROLE OF SIRTUIN IN CIGARETTE SMOKE-INDUCED LUNG INFLAMMATION AND INJURY
    Irfan Rahman; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Chronic Obstructive Pulmonary Disease (COPD) is the fourth leading cause of chronic morbidity and mortality in the United States, affecting an estimated 23 million people...
  11. A novel telomerase expressing lung fibroblast phenotype
    Sem H Phan; Fiscal Year: 2012
    ..induction in pathogenesis of chronic fibrotic lung diseases, such as interstitial lung diseases, chronic obstructive pulmonary disease (COPD) and asthma...
  12. Dependency of O-3 Induced Lung Mucus Hypersecretion on NQ01
    W Michael Foster; Fiscal Year: 2010
    ..For patients with asthma, chronic obstructive pulmonary disease (COPD), and cystic fibrosis, mucus hypersecretion is now being considered as a risk factor for ..
  13. Immune modulators of inflammation in servere COPD
    Farrah Kheradmand; Fiscal Year: 2010
    Tobacco related lung diseases, including chronic obstructive pulmonary disease (COPD) with and without emphysema, are among the major causes of lung-related disability and death worldwide...
  14. Tadalafil for Pulmonary Hypertension Associated with Chronic Lung Disease
    SHARON IRENE SMITH ROUNDS; Fiscal Year: 2013
    ..0 Wood units, pulmonary capillary wedge pressure [PCWP] <18 mm Hg) due to chronic obstructive pulmonary disease (COPD) GOLD stage II or higher, FEV1/FVC <70 and FEV1 <79% of predicted)...
  15. The Effects of PP2A on TNF Signaling and Smoke-Induced Lung Injury
    Robert F Foronjy; Fiscal Year: 2013
    ..In fact, the age-adjusted mortality for chronic obstructive pulmonary disease (COPD) has risen 71% over the past thirty years...
  16. Fate of Lung Stem Cells During Pulmonary Disease
    Susan M Majka; Fiscal Year: 2012
    ..PUBLIC HEALTH RELEVANCE: Pulmonary hypertension, chronic obstructive pulmonary disease, interstitial pulmonary fibrosis and other adult lung conditions are a major cause of morbidity ..
  17. Biomarkers to Assess Selenium Chemoprevention for NSCLC
    Steven A Belinsky; Fiscal Year: 2012
    ..A nested, case-control study of high-risk smokers with chronic obstructive pulmonary disease revealed that a panel of genes could predict incident lung cancer 3 - 18 months prior to clinical ..
  18. Pulmonary effects of biomass fuel indoor PM from rural India
    Shyam Biswal; Fiscal Year: 2013
    ..that exposure to biomass smoke might be the biggest risk factor for respiratory diseases such as chronic obstructive pulmonary disease (COPD), asthma, and respiratory infections globally...
  19. Epigenetic Alterations in IPF Fibroblastic Foci
    YAN SANDERS; Fiscal Year: 2010
    ..to characterize global and gene-specific alterations in DNA methylation in IPF in comparison to chronic obstructive pulmonary disease (COPD), in order to establish epigenetic alterations as an important pathogenic mechanism in IPF...
  20. MNEI/SerpinB1: A modulator of innate pulmonary defense
    EILEEN REMOLD-O'DONNELL; Fiscal Year: 2010
    ..or necrotic neutrophils are major contributors to the pathology of cystic fibrosis and chronic obstructive pulmonary disease (COPD)...
  21. The RAGE of COPD
    John R Hoidal; Fiscal Year: 2013
    ..Background: Chronic obstructive pulmonary disease (COPD) is a devastating disorder characterized by chronic airflow limitation...
  22. Neprilysin and Pulmonary Vascular Remodeling: Cellular and Molecular Mechanisms
    EDWARD CHARLES DEMPSEY; Fiscal Year: 2013
    ..in the general and Veteran populations, and complicates most lung and heart disorders, including chronic obstructive pulmonary disease (COPD)...
  23. HYPONATREMIA-INDUCED OSTEOPOROSIS
    Joseph G Verbalis; Fiscal Year: 2010
    ..hormonal and metabolic abnormalities in 44%, and chronic diseases of the gastrointestinal tract, chronic obstructive pulmonary disease, organ transplantation, autoimmune diseases, genetic diseases, and marrow-based and neoplastic ..
  24. Moraxella catarrhalis: virulence-based prevention
    Timothy F Murphy; Fiscal Year: 2013
    ..of otitis media in children, and lower respiratory tract infections (exacerbations) in adults with chronic obstructive pulmonary disease (COPD)...
  25. Developing a New Antioxidant Activator to Intervene in Lung Inflammatory Diseases
    JOHN WILLIMANN; Fiscal Year: 2009
    ..S. These diseases include allergic asthma, chronic obstructive pulmonary disease, viral and bacterial infections, and related sepsis-induced acute lung injury...
  26. Exposure and biological response biomarkers of cigarette smoke
    IAN ALEXANDER BLAIR; Fiscal Year: 2010
    ..tobacco smoke is associated with oxidative stress, pancreatic cancer, cardiovascular disease, and chronic obstructive pulmonary disease (COPD), although the specific role of PAHs is not clear...
  27. Genetic Determinants of Lung Injury
    Beverly H Koller; Fiscal Year: 2013
    ..been implicated in the pathogenesis of many acute and chronic lung diseases including asthma and chronic obstructive pulmonary disease (COPD)...
  28. Effects of lymphangiogenesis stimulation on lung allograft rejection
    Souheil El-Chemaly; Fiscal Year: 2013
    ..therapy proven to prolong survival and improve quality of life in advanced lung diseases such as chronic obstructive pulmonary disease (COPD) and idiopathic pulmonary fibrosis (IPF)...
  29. Statins for Pulmonary and Cardiac Complications of Chronic HIV (The SPARC Trial)
    Stephen R Wisniewski; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Growing evidence indicates that chronic obstructive pulmonary disease (COPD) is an important cause of respiratory impairment in HIV+ persons and will likely increase as the HIV+ population continues ..
  30. Mechanisms and consequences of sleep disordered breathing in COPD
    Cynthia D Brown; Fiscal Year: 2012
    ..research is to better understand the mechanisms and consequences of sleep- disordered breathing in chronic obstructive pulmonary disease (COPD)...
  31. Evolutionary Analysis of the Histone Deacetylase Family: Biomedical Research
    JOSEPH LEWIS GRAVES; Fiscal Year: 2011
    ..HIV infection, various cancers, GPI deficiency, ulcerative colitis, sickle cell disease, and chronic obstructive pulmonary disease among others...
  32. Abnormality in Gene Expression of Key Mediators of Vitamin A Action in COPD
    Salil K Das; Fiscal Year: 2010
    Chronic bronchitis and emphysema are two kinds of chronic obstructive pulmonary disease (COPD), which are important causes of morbidity and mortality in the United States...
  33. Developing Nrf2 as a target for treatment of corticosteroid resistance in COPD
    Robert A Wise; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Chronic Obstructive Pulmonary Disease (COPD) is a highly morbid disease, mainly caused by cigarette smoking in the United States, affecting 24 million people...
  34. Role of interleukin-17 and iNKT cells in COPD
    ABDALA EL KHAL; Fiscal Year: 2010
    b>Chronic obstructive pulmonary disease (COPD) has been increasing for the past years. Today COPD is the most common cause of death in the US and is classified amongst the top five killers...
  35. The Unfolded Protein Response in Human Airway and Alveolar Epithelial Cells
    Salim Merali; Fiscal Year: 2010
    Cigarette smoking induced chronic obstructive pulmonary disease (COPD) is characterized by alveolar epithelial cell death and airway metaplasia and fibrosis...
  36. Diet, Biomarkers and Lung Function
    Rui Jiang; Fiscal Year: 2010
    ..The major clinical manifestation of low lung function, chronic obstructive pulmonary disease (COPD), is the fourth leading cause of death in the United States...
  37. CFTR Biogenesis and Function in Epithelia
    Zsuzsa Bebok; Fiscal Year: 2012
    ..Understanding these processes are important in understanding the cellular basis for a number of lung pathologies including cystic fibrosis and chronic obstructive pulmonary disease (COPD).
  38. Developmental Physiology of Ciliated Epithelia
    CHRISTOPHER ROBERT KINTNER; Fiscal Year: 2012
    ..respiratory tract is a contributing factor to morbidity in chronic asthma, cystic fibrosis, and chronic obstructive pulmonary disease. Despite their importance to human health, the cellular and molecular mechanisms that underlie the ..
  39. Modulation of Genes Responsible for Cilia Length by Exposure to Cigarette Smoke
    Ann E Tilley; Fiscal Year: 2013
    ..Research. Cigarette smoking is the major risk factor for the development of chronic obstructive pulmonary disease (COPD)...
  40. 5500 Q-Trap Mass Spectrometer
    Stephen Barnes; Fiscal Year: 2010
    ..will also allow measurement of small peptides such as those produced from collagen in the lung in chronic obstructive pulmonary disease to be measured in more convenient/accessible fluids such plasma or urine...
  41. MULTIDISCIPLINARY TRAINING IN PULMONARY RESEARCH
    MARK WALTER FRAMPTON; Fiscal Year: 2013
    ..lung immunology, inflammation and infection;pulmonary fibrosis and remodeling;tobacco smoke and chronic obstructive pulmonary disease;and health effects of air pollution...
  42. Clinical trial of air cleaners to improve indoor air quality and COPD health
    Nadia N Hansel; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Chronic obstructive pulmonary disease (COPD) is a progressive disease characterized by lung injury and inflammation...
  43. Enhancing Nrf2 by Sulforaphane Treatment in COPD
    Robert A Wise; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Chronic Obstructive Pulmonary Disease (COPD) is a major cause of morbidity and mortality in the United States and is a growing cause of chronic disease internationally...
  44. Effects of ozone exposure on expression and function of surfactant protein D
    Angela Haczku; Fiscal Year: 2010
    ..Chronic inflammatory diseases of the airways such as asthma or chronic obstructive pulmonary disease (COPD) arise from a complex interaction between genetic factors and environmental exposures...
  45. TSQ Vantage Bundle with Acquity UltraPerformance LC
    Nicolaas E Deutz; Fiscal Year: 2010
    ..exposure;sepsis (blood infection) coming from major infection;muscle wasting accompanying chronic obstructive pulmonary disease (COPD);and disturbed fatty acid and protein metabolism associated with a spectrum of conditions, ..
  46. Perinatal Stress and programming of childhood wheeze and lung function
    Rosalind J Wright; Fiscal Year: 2013
    ..and lung development are of particular interest given the link between these factors and chronic obstructive pulmonary disease (COPD) in later life. COPD is projected to be the fourth leading cause of death worldwide by 2020...
  47. Pulmonary Vascular Changes in Early Chronic Obstructive Pulmonary Disease (COPD)
    R Graham Barr; Fiscal Year: 2011
    DESCRIPTION (provided by investigator): Chronic obstructive pulmonary disease (COPD) is currently the fourth leading cause of death in the United States...
  48. Cardiopulmonary structure and function in Multi-Ethnic Study of Atherosclerosis
    R Graham Barr; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Chronic obstructive pulmonary disease (COPD) is the fourth leading cause of death in the United States. COPD will overtake stroke as the third leading cause of death within 7 years...
  49. Transcriptional Control of Submucosal Gland Formation and Function
    Jeffrey A Whitsett; Fiscal Year: 2013
    ..and host defense accompany common chronic lung diseases, including cystic fibrosis (CF), chronic obstructive pulmonary disease, and asthma...
  50. Eicosapentaenoic acid and protein modulation to induce anabolism in COPD
    MARIELLE PKJ ENGELEN; Fiscal Year: 2012
    b>Chronic Obstructive Pulmonary Disease (COPD) is considered a systemic disease that involves pathology in several extra pulmonary tissues...
  51. Effect of Macrolide Treatment on a Novel Pathway of Neutrophilic Inflammation in
    J Edwin Blalock; Fiscal Year: 2010
    ..a new pathway signaling neutrophil (PMN) influx and damage to the airways that may play a role in chronic obstructive pulmonary disease (COPD)...
  52. Genetic Analysis of Murine Chronic Hypoxia-Induced Pulmonary Hypertension
    William C Nichols; Fiscal Year: 2013
    ..failure in patients with pulmonary arterial hypertension (PAH), interstitial lung diseases and chronic obstructive pulmonary disease (COPD)...
  53. Role of the Aryl Hydrocarbon Receptor in Lung Inflammation
    PATRICIA JANET SIME; Fiscal Year: 2012
    ..Furthermore, cigarette smoke is the primary cause of chronic obstructive pulmonary disease (COPD-emphysema and chronic bronchitis)...
  54. Host-associated regulation of P. aeruginosa colonization and virulence
    Deborah A Hogan; Fiscal Year: 2013
    ..aeruginosa is a common cause of ventilator-associated pneumonia, exacerbations in patients with chronic obstructive pulmonary disease, and chronic, lethal infections in individuals with the genetic disease cystic fibrosis...
  55. 2013 Elastin, Elastic Fibers &Microfibrils Gordon Research Conference &Gordon R
    Zsolt Urban; Fiscal Year: 2013
    ..is central to the pathogenesis of acquired diseases including atherosclerosis, aneurysms, chronic obstructive pulmonary disease, vascular remodeling in systemic and pulmonary hypertension, and skin aging mechanisms...
  56. Genes Mediating Innate Immune Suppression by Hypercapnia in Mammals and Flies
    PETER H SPORN; Fiscal Year: 2013
    ..of PCO2 in blood and tissue, commonly occurs in severe acute and chronic lung disorders, such as chronic obstructive pulmonary disease (COPD)...
  57. Role of PPAR-gamma in Smoking-induced COPD Progression and Steroid Resistance
    Raju C Reddy; Fiscal Year: 2013
    ..will test whether a novel approach based on activation of PPAR-g can inhibit progression of chronic obstructive pulmonary disease (COPD) and possibly restore glucocorticoid responsiveness...
  58. Novel Protective Antiapoptotic Action of Alpha 1-Antitrypsin In Emphysema
    Rubin M Tuder; Fiscal Year: 2011
    ..due to disruption of lung cellular maintenance determines the magnitude of lung destruction in chronic obstructive pulmonary disease (COPD)...
  59. Genome-wide and Linkage Study of Quantitative Emphysema Phenotypes
    Stephen S Rich; Fiscal Year: 2010
    ..Together, emphysema and chronic obstructive pulmonary disease (COPD) will soon surpass stroke as the third leading cause of death in the United States, with the ..
  60. Heme, Iron and Oxidative Stress: Regulation of Iron Homeostasis in H. Influenzae
    Robert S Munson; Fiscal Year: 2013
    ..human pathogen as it is a major cause of otitis media (OM), sinusitis, exacerbations of chronic obstructive pulmonary disease (COPD) and bronchitis...
  61. Aldosterone and Sodium Regulation in Postural Tachycardia Syndrome
    Satish R Raj; Fiscal Year: 2013
    ..health-related quality of life, to levels comparable to patients with congestive heart failure or chronic obstructive pulmonary disease. While grossly elevated heart rates are the hallmark physiologic findings in POTS, there are ..
  62. Obesity, Inflammation, and Lung Injury After Lung Transplantation
    David J Lederer; Fiscal Year: 2013
    ..life-saving therapy for adults with advanced lung diseases, such as interstitial lung disease and chronic obstructive pulmonary disease. The success of lung transplantation is limited by poor early and late outcomes...
  63. Metals in exhaled breath condensate as COPD biomarkers
    Antonio Mutti; Fiscal Year: 2005
    b>Chronic obstructive pulmonary disease (COPD) is a major health problem worldwide and is increasing with a high prevalence, high morbidity and high cost...
  64. Adenovirus Persistence in Human Lymphoid Tissues
    Linda Gooding; Fiscal Year: 2007
    ..believed to be benign, recent studies linking adenovirus to chronic ailments such as asthma, chronic obstructive pulmonary disease, and small cell lung cancer suggest that these viruses may contribute to more serious diseases...
  65. Translating COPD Guidelines inot Primary Care Practice
    Donna Parker; Fiscal Year: 2009
    ..the translation of the Gold (the Global Strategy for the Diagnosis, Management, and Prevention of Chronic Obstructive Pulmonary Disease) COPD guidelines into primary care practice...
  66. Shared Decision-Making in End-Stage Heart & Lung Disease
    Mark Sullivan; Fiscal Year: 2005
    Congestive heart failure (CHF) and chronic obstructive pulmonary disease (COPD) are among the most common causes of death in U.S. adults, yet they have received relatively little attention in the hospice or palliative care literature...
  67. Domestic endotoxin exposure and chronic obstructive pulmonary disease
    Nadia Hansel; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Chronic obstructive pulmonary disease (COPD) is the fourth leading cause of death in the United States and is a progressive disease characterized by lung injury and inflammation...
  68. Testing a Measurement Model of Acute Dyspnea
    Mark Parshall; Fiscal Year: 2005
    ..derived from a preliminary study of dyspnea in emergency department patients with exacerbated chronic obstructive pulmonary disease (COPD)...
  69. HE3 MR Diffusion & Low Dose CT Quantitation of Emphysema
    David Gierada; Fiscal Year: 2005
    ..and destruction of airspace walls, and is commonly present in the millions of patients with chronic obstructive pulmonary disease. Increased knowledge regarding the role of inflammatory mechanisms and proteinases in the ..
  70. EMPHYSEMA--INFLUENCES ON DIAPHRAGM FATIGUE RESISTANCE
    Michael Lewis; Fiscal Year: 1992
    Undernutrition is an important complicating factor in chronic obstructive pulmonary disease (COPD) resulting in altered diaphragmatic strength and endurance, due to atrophy of fast- twitch muscle fibers corticosteroids, which are often ..
  71. Experimental COPD: remediation, mitigation
    DONALD JOHN MASSARO; Fiscal Year: 2010
    ..knowledge that can be used to mitigate, and remediate, alveolar loss in individuals with chronic obstructive pulmonary disease (COPD)...
  72. PROVIDING TELE HOME CARE TO CHRONICALLY ILL RURAL OLDER
    Pamela Whitten; Fiscal Year: 2000
    ..study which first looks at the feasibility and organizational delivery impacts of monitoring chronic obstructive pulmonary disease (COPD) and congestive heart failure (CHF) patients who are attempting to manage their condition ..
  73. Redox Biology in COPD
    Yvonne Janssen Heininger; Fiscal Year: 2009
    PROJECT SUMMARY/ABSTRACT It is well known that oxidative stress contributes to the pathogenesis of Chronic Obstructive Pulmonary Disease (COPD)...
  74. INTRATHORACIC ARTIFICIAL LUNGS
    LYLE MOCKROS; Fiscal Year: 2000
    ..They can be used as a bridge-to-transplant for the tens of thousands who die each year from chronic obstructive pulmonary disease, cystic fibrosis, or idiopathic pulmonary fibrosis or a therapy for approximately 75,000 who die ..
  75. INHALED PARTICLE CHARACTERISTICS AND EARLY LUNG EFFECTS
    William Beckett; Fiscal Year: 2002
    DESCRIPTION: (Adapted from the Investigator's Abstract) Chronic obstructive pulmonary disease (COPD) is a disabling condition produced by chronic bronchitis (airway inflammation and mucus hypersecretion) and emphysema (loss of alveolar ..
  76. DIET AND CHRONIC OBSTRUCTIVE PULMONARY DISEASE
    Carlos Camargo; Fiscal Year: 2002
    b>Chronic obstructive pulmonary disease (COPD) morbidity and mortality are rising, a trend that is unique among the top five causes of death in the USA...