bronchiolitis obliterans

Summary

Summary: Inflammation of the bronchioles with obstruction by fibrous granulation tissue or bronchial exudate. It may follow inhalation of irritating gases or foreign bodies and it complicates pneumonia.

Top Publications

  1. ncbi Bronchiolitis obliterans syndrome: the final frontier for lung transplantation
    Jamie L Todd
    Department of Internal Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Chest 140:502-8. 2011
  2. ncbi Revision of the 1996 working formulation for the standardization of nomenclature in the diagnosis of lung rejection
    Susan Stewart
    Papworth Everard Pathology Department, Papworth Hospital, Cambridge, UK
    J Heart Lung Transplant 26:1229-42. 2007
  3. ncbi Bronchiolitis obliterans syndrome 2001: an update of the diagnostic criteria
    Marc Estenne
    Erasme University Hospital, Brussels, Belgium
    J Heart Lung Transplant 21:297-310. 2002
  4. ncbi Impact of graft colonization with gram-negative bacteria after lung transplantation on the development of bronchiolitis obliterans syndrome in recipients with cystic fibrosis
    J Gottlieb
    Department of Respiratory Medicine OE6870, Hannover Medical School, Carl Neuberg Strasse 1, 30625 Hannover, Germany
    Respir Med 103:743-9. 2009
  5. ncbi Decreased efferocytosis and mannose binding lectin in the airway in bronchiolitis obliterans syndrome
    Sandra Hodge
    Lung Research Laboratory, Hanson Institute and Thoracic Medicine, Royal Adelaide Hospital, Adelaide, Australia
    J Heart Lung Transplant 30:589-95. 2011
  6. ncbi Bronchiolitis obliterans in children
    Siby P Moonnumakal
    Pediatric Pulmonary Section, Department of Pediatrics, Texas Children s Hospital, USA
    Curr Opin Pediatr 20:272-8. 2008
  7. ncbi Bile acid aspiration and the development of bronchiolitis obliterans after lung transplantation
    Frank D'Ovidio
    Toronto Lung Transplant Program, University of Toronto, Toronto General Hospital, 200 Elizabeth Street, Toronto, Ontario, Canada M5G 2C4
    J Thorac Cardiovasc Surg 129:1144-52. 2005
  8. pmc Neutralizing IL-17 prevents obliterative bronchiolitis in murine orthotopic lung transplantation
    L Fan
    Department of General Surgery, The First Affiliated Hospital, Xi an Jiaotong University School of Medicine, Xi an, China
    Am J Transplant 11:911-22. 2011
  9. ncbi Cytomegalovirus replication within the lung allograft is associated with bronchiolitis obliterans syndrome
    M Paraskeva
    Department of Allergy, Immunology and Respiratory Medicine, Alfred Hospital Melbourne Vic 3181, Australia ANZIC RC
    Am J Transplant 11:2190-6. 2011
  10. ncbi Decreased percentage of CD4+FoxP3+ cells in bronchoalveolar lavage from lung transplant recipients correlates with development of bronchiolitis obliterans syndrome
    Sangeeta M Bhorade
    Section of Pulmonary, Department of Medicine, The University of Chicago, Chicago, IL 60637, USA
    Transplantation 90:540-6. 2010

Research Grants

Detail Information

Publications300 found, 100 shown here

  1. ncbi Bronchiolitis obliterans syndrome: the final frontier for lung transplantation
    Jamie L Todd
    Department of Internal Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Chest 140:502-8. 2011
    b>Bronchiolitis obliterans syndrome (BOS) is a form of chronic lung allograft dysfunction that affects a majority of lung transplant recipients and is the principal factor limiting long-term transplant survival...
  2. ncbi Revision of the 1996 working formulation for the standardization of nomenclature in the diagnosis of lung rejection
    Susan Stewart
    Papworth Everard Pathology Department, Papworth Hospital, Cambridge, UK
    J Heart Lung Transplant 26:1229-42. 2007
    ..This consensus revision of the working formulation was approved by the ISHLT board of directors in April 2007...
  3. ncbi Bronchiolitis obliterans syndrome 2001: an update of the diagnostic criteria
    Marc Estenne
    Erasme University Hospital, Brussels, Belgium
    J Heart Lung Transplant 21:297-310. 2002
  4. ncbi Impact of graft colonization with gram-negative bacteria after lung transplantation on the development of bronchiolitis obliterans syndrome in recipients with cystic fibrosis
    J Gottlieb
    Department of Respiratory Medicine OE6870, Hannover Medical School, Carl Neuberg Strasse 1, 30625 Hannover, Germany
    Respir Med 103:743-9. 2009
    b>Bronchiolitis obliterans syndrome (BOS) represents the leading cause of late mortality after lung transplantation (LTx)...
  5. ncbi Decreased efferocytosis and mannose binding lectin in the airway in bronchiolitis obliterans syndrome
    Sandra Hodge
    Lung Research Laboratory, Hanson Institute and Thoracic Medicine, Royal Adelaide Hospital, Adelaide, Australia
    J Heart Lung Transplant 30:589-95. 2011
    ..MBL and efferocytosis in other chronic inflammatory lung diseases; we therefore hypothesized that reduced MBL and efferocytosis in the airways may be a determinant of bronchiolitis obliterans syndrome (BOS) after lung transplantation.
  6. ncbi Bronchiolitis obliterans in children
    Siby P Moonnumakal
    Pediatric Pulmonary Section, Department of Pediatrics, Texas Children s Hospital, USA
    Curr Opin Pediatr 20:272-8. 2008
    In this review, we discuss recent advances in our understanding of the etiology, pathology and pathogenesis, clinical presentation, diagnosis, treatment, and outcome of bronchiolitis obliterans in the nontransplant, pediatric population.
  7. ncbi Bile acid aspiration and the development of bronchiolitis obliterans after lung transplantation
    Frank D'Ovidio
    Toronto Lung Transplant Program, University of Toronto, Toronto General Hospital, 200 Elizabeth Street, Toronto, Ontario, Canada M5G 2C4
    J Thorac Cardiovasc Surg 129:1144-52. 2005
    Aspiration of gastroesophageal refluxate may contribute to lung transplant bronchiolitis obliterans syndrome (BOS). We investigated bile acids in bronchoalveolar lavage fluid (BALF) and studied its role in BOS.
  8. pmc Neutralizing IL-17 prevents obliterative bronchiolitis in murine orthotopic lung transplantation
    L Fan
    Department of General Surgery, The First Affiliated Hospital, Xi an Jiaotong University School of Medicine, Xi an, China
    Am J Transplant 11:911-22. 2011
    ..In addition, these data indicate that neutralizing IL-17A or augmenting IL-10 could be therapeutic interventions to prevent OB...
  9. ncbi Cytomegalovirus replication within the lung allograft is associated with bronchiolitis obliterans syndrome
    M Paraskeva
    Department of Allergy, Immunology and Respiratory Medicine, Alfred Hospital Melbourne Vic 3181, Australia ANZIC RC
    Am J Transplant 11:2190-6. 2011
    Early studies reported cytomegalovirus (CMV) pneumonitis as a risk factor for development of bronchiolitis obliterans syndrome (BOS) following lung transplantation...
  10. ncbi Decreased percentage of CD4+FoxP3+ cells in bronchoalveolar lavage from lung transplant recipients correlates with development of bronchiolitis obliterans syndrome
    Sangeeta M Bhorade
    Section of Pulmonary, Department of Medicine, The University of Chicago, Chicago, IL 60637, USA
    Transplantation 90:540-6. 2010
    ..Alloimmune responses play an important role in progression to chronic rejection that manifests as bronchiolitis obliterans syndrome (BOS), but no biomarker can currently predict the progression to BOS...
  11. ncbi The impact of traffic air pollution on bronchiolitis obliterans syndrome and mortality after lung transplantation
    Tim S Nawrot
    Centre for Environmental Sciences, Hasselt University, Diepenbeek, Belgium
    Thorax 66:748-54. 2011
    Approximately half of all patients who underwent a lung transplantation suffer from bronchiolitis obliterans syndrome (BOS), the clinical correlate of chronic rejection, within 5 years after transplantation...
  12. ncbi Bronchiolitis obliterans in children: clinical profile and diagnosis
    P W Chan
    Department of Paediatrics, University Malaya Medical Centre, Kuala Lumpur, Malaysia
    Respirology 5:369-75. 2000
    The aim of the study was to determine the clinical profile, aetiology and radiological categories in children diagnosed with bronchiolitis obliterans (BO).
  13. ncbi Chronic lung allograft rejection: mechanisms and therapy
    John A Belperio
    Division of Pulmonary, Critical Care Medicine, Allergy, and Clinical Immunology, Department of Internal Medicine, The David Geffen School of Medicine at UCLA, Los Angeles, California, USA
    Proc Am Thorac Soc 6:108-21. 2009
    ..therapy, chronic lung rejection, in the form of obliterative bronchiolitis or its clinical correlate bronchiolitis obliterans syndrome (BOS), continues to be highly prevalent and is the major limitation to long-term survival...
  14. ncbi Xenon ventilation CT using dual-source and dual-energy technique in children with bronchiolitis obliterans: correlation of xenon and CT density values with pulmonary function test results
    Hyun Woo Goo
    Department of Radiology and Research Institute of Radiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea
    Pediatr Radiol 40:1490-7. 2010
    ..To expand its clinical applications evidence of additional diagnostic value of xenon ventilation CT over conventional chest CT is required...
  15. ncbi Improved lung allograft function after fundoplication in patients with gastroesophageal reflux disease undergoing lung transplantation
    R Duane Davis
    Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA
    J Thorac Cardiovasc Surg 125:533-42. 2003
    b>Bronchiolitis obliterans is the greatest limitation to the long-term applicability of lung transplantation...
  16. ncbi The role of the IL23/IL17 axis in bronchiolitis obliterans syndrome after lung transplantation
    B M Vanaudenaerde
    Laboratory of Pneumology, Katholieke Universiteit Leuven, Leuven, Belgium
    Am J Transplant 8:1911-20. 2008
    b>Bronchiolitis obliterans syndrome (BOS) is the leading cause of death after lung transplantation. Treatment is challenging, as the precise pathophysiology remains unclear...
  17. pmc Cxcr3 and its ligand CXCL10 are expressed by inflammatory cells infiltrating lung allografts and mediate chemotaxis of T cells at sites of rejection
    C Agostini
    Department of Clinical and Experimental Medicine, Padua University School of Medicine, Padua, Italy
    Am J Pathol 158:1703-11. 2001
    ....
  18. ncbi Clinical course of postinfectious bronchiolitis obliterans
    L Zhang
    Departamento Materno Infantil, Fundacao Universidade do Rio Grande, Rio Grande, Brazil
    Pediatr Pulmonol 29:341-50. 2000
    ..study to define the clinical course and the prognostic factors of 31 patients with postinfectious bronchiolitis obliterans. All patients presented with an episode of acute bronchiolitis in the first 2 years of life, and ..
  19. ncbi Histology of childhood bronchiolitis obliterans
    Thais Mauad
    Department of Pathology, Faculty of Medicine, University of Sao Paulo, Sao Paulo, Brazil
    Pediatr Pulmonol 33:466-74. 2002
    Childhood bronchiolitis obliterans (CBO) is an uncommon disease characterized by persistent signs and symptoms of obstructive respiratory disease after an acute bronchiolar injury...
  20. pmc A new murine model for bronchiolitis obliterans post-bone marrow transplant
    Angela Panoskaltsis-Mortari
    University of Minnesota, Department of Pediatrics, Division of Hematology Oncology, Minneapolis, MN 55455, USA
    Am J Respir Crit Care Med 176:713-23. 2007
    b>Bronchiolitis obliterans (BO) is a major problem in lung transplantation and is also part of the spectrum of late-onset pulmonary complications that can occur after hematopoietic stem cell transplant...
  21. ncbi Altered progenitor cell and cytokine profiles in bronchiolitis obliterans syndrome
    Sarah E Gilpin
    University Health Network, Latner Thoracic Surgery Research Laboratories, University of Toronto, Toronto, Ontario, Canada
    J Heart Lung Transplant 31:222-8. 2012
    ..Interplay between these populations has not yet been studied in bronchiolitis obliterans syndrome (BOS) post-lung transplant.
  22. ncbi Adenovirus pneumonia in infants and factors for developing bronchiolitis obliterans: a 5-year follow-up
    Jose A Castro-Rodriguez
    Department of Pediatric Respiratory Medicine, Faculty of Medical Sciences, University of Santiago de Chile, Santiago, Chile
    Pediatr Pulmonol 41:947-53. 2006
    ..with adenovirus pneumonia and determine the factors that potentially contributed to the development of bronchiolitis obliterans (BO)...
  23. ncbi A potent anti-angiogenic factor, vasohibin-1, ameliorates experimental bronchiolitis obliterans
    T Watanabe
    Department of Thoracic Surgery, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan
    Transplant Proc 44:1155-7. 2012
    b>Bronchiolitis obliterans (BO) is a major cause of morbidity and mortality after lung transplantation. BO is pathologically characterized by neovascularized fibro-obliteration of the allograft airway...
  24. ncbi Pos-infectious bronchiolitis obliterans in children
    Ana Luísa Lobo
    Paediatric Unit, Hospital Padre Américo Vale do Sousa, Lugar do Tapadinho, 4560 162 Guilhufe Penafiel
    Rev Port Pneumol 13:495-509. 2007
    b>Bronchiolitis obliterans (BO) is a rare disease in immunocompetent children that usually occurs after infection of the lower airways...
  25. ncbi Clinical prediction rule to diagnose post-infectious bronchiolitis obliterans in children
    Alejandro J Colom
    Respiratory Centre, R Gutierrez Children s Hospital of Buenos Aires, Buenos Aires, Argentina
    Pediatr Pulmonol 44:1065-9. 2009
    Infant pulmonary function testing has a great value in the diagnosis of post-infectious bronchiolitis obliterans (BOs), because of characteristic patterns of severe and fixed airway obstruction...
  26. ncbi Bronchiolitis obliterans in children: clinical presentation, therapy and long-term follow-up
    Chih Yung Chiu
    Department of Pediatrics, Chang Gung Memorial Hospital, Graduate Institute of Clinical Medical Sciences, Chang Gung University College of Medicine, Taoyuan, Taiwan
    J Paediatr Child Health 44:129-33. 2008
    To delineate the predisposing factors, clinical, radiological features and outcomes of bronchiolitis obliterans (BO) in children for minimising morbidity and mortality.
  27. pmc Constrictive bronchiolitis in soldiers returning from Iraq and Afghanistan
    Matthew S King
    Division of Pulmonary and Critical Care Medicine, Meharry Medical College, Nashville, TN, USA
    N Engl J Med 365:222-30. 2011
    ..S. Army's standards for physical fitness...
  28. pmc Alloimmunity-induced autoimmunity as a potential mechanism in the pathogenesis of chronic rejection of human lung allografts
    Deepti Saini
    Department of Surgery, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Heart Lung Transplant 30:624-31. 2011
    b>Bronchiolitis obliterans syndrome (BOS) is a major cause of morbidity and mortality after lung transplantation (LTx)...
  29. pmc Mesenchymal stromal cells in bronchoalveolar lavage as predictors of bronchiolitis obliterans syndrome
    Linda Badri
    1500 East Medical Center Drive, 3916 Taubman Center, Ann Arbor, MI 48109 0360, USA
    Am J Respir Crit Care Med 183:1062-70. 2011
    ..However, the clinical relevance of this novel cellular component of BAL and its association with bronchiolitis obliterans syndrome (BOS), a disease marked by progressive airflow limitation secondary to fibrotic obliteration of ..
  30. pmc Mannose-binding lectin deficiency linked to cytomegalovirus (CMV) reactivation and survival in lung transplantation
    J M Kwakkel-van Erp
    Respiratory Medicine, University Medical Center Utrecht, Utrecht, The Netherlands
    Clin Exp Immunol 165:410-6. 2011
    Despite the use of immunosuppressives mainly influencing T and B cell responses, the prevalence of the bronchiolitis obliterans syndrome (BOS) after lung transplantation is high...
  31. ncbi Bronchiolitis obliterans after allogeneic hematopoietic stem cell transplantation
    Kirsten M Williams
    Experimental Transplantation and Immunology Branch, National Cancer Institute, Bldg 10 CRC, Room 3 3288, 10 Center Dr, Bethesda, MD 20892, USA
    JAMA 302:306-14. 2009
    ..When chronic graft-vs-host disease affects the lung tissue, bronchiolitis obliterans syndrome ensues...
  32. pmc A shift in the collagen V antigenic epitope leads to T helper phenotype switch and immune response to self-antigen leading to chronic lung allograft rejection
    V Tiriveedhi
    Department of Surgery, Washington University School of Medicine, St Louis, MO 63110, USA
    Clin Exp Immunol 167:158-68. 2012
    ..HLA) and self-antigen collagen V (Col-V) have been proposed in the pathogenesis of chronic rejection (bronchiolitis obliterans syndrome, BOS) following human lung transplantation (LTx)...
  33. ncbi Severity of lymphocytic bronchiolitis predicts long-term outcome after lung transplantation
    Allan R Glanville
    The Lung Transplant Unit, St Vincent s Hospital, Darlinghurst, New South Wales, Australia
    Am J Respir Crit Care Med 177:1033-40. 2008
    ..Severe and recurrent acute vascular rejection of the pulmonary allograft is an accepted major risk factor for obliterative bronchiolitis...
  34. pmc The heterotopic tracheal allograft as an animal model of obliterative bronchiolitis
    D J Hele
    Imperial College School of Medicine, London, UK
    Respir Res 2:169-83. 2001
    ....
  35. ncbi A dichotomy in bronchiolitis obliterans syndrome after lung transplantation revealed by azithromycin therapy
    B M Vanaudenaerde
    Laboratory of Pneumology, Katholieke Universiteit Leuven, Leuven, Belgium
    Eur Respir J 32:832-43. 2008
    b>Bronchiolitis obliterans syndrome (BOS) is the most important cause of late mortality following lung transplantation, resulting in major morbidity and a huge burden on healthcare resources...
  36. ncbi HLA-specific antibodies are risk factors for lymphocytic bronchiolitis and chronic lung allograft dysfunction
    Alin L Girnita
    Department of Pathology, University of Pittsburgh, Pittsburgh, PA, USA
    Am J Transplant 5:131-8. 2005
    b>Bronchiolitis obliterans syndrome (BOS) represents a major limitation in lung transplantation. While acute rejection is widely considered the most important risk factor for BOS, the impact of HLA-specific antibodies is less understood...
  37. ncbi Anti-HLA class I antibody binding to airway epithelial cells induces production of fibrogenic growth factors and apoptotic cell death: a possible mechanism for bronchiolitis obliterans syndrome
    Andres Jaramillo
    Department of Surgery, Washington University School of Medicine, St Louis, MO 63110, USA
    Hum Immunol 64:521-9. 2003
    Development of anti-HLA class I antibodies is associated with bronchiolitis obliterans syndrome (BOS) after lung transplantation. BOS is characterized histologically by significant fibrosis and airway epithelial cell (AEC) apoptosis...
  38. ncbi Azithromycin therapy for patients with bronchiolitis obliterans syndrome after lung transplantation
    Geert M Verleden
    University Hospital Gasthuisberg, Department of Respiratory Medicine and Lung Transplantation Unit, Leuven, Belgium
    Transplantation 77:1465-7. 2004
    b>Bronchiolitis obliterans syndrome (BOS) is the leading cause of late mortality after lung transplantation.
  39. ncbi Bronchiolitis obliterans syndrome in lung transplant recipients: can thin-section CT findings predict disease before its clinical appearance?
    Eli Konen
    Department of Medical Imaging, Toronto General Hospital, University Health Network, Ontario, Canada
    Radiology 231:467-73. 2004
    To determine whether there are thin-section computed tomographic (CT) features that predict bronchiolitis obliterans syndrome (BOS) in lung transplant recipients before the clinical appearance and during the early stages of the disease.
  40. ncbi Aerosol cyclosporin therapy in lung transplant recipients with bronchiolitis obliterans
    A T Iacono
    Division of Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    Eur Respir J 23:384-90. 2004
    The majority of patients who develop bronchiolitis obliterans, after lung transplantation, die within 2-3 yrs after onset since treatment with conventional immunosuppression is typically ineffective...
  41. ncbi Bronchiolitis obliterans following lung transplantation
    Iskander Al-Githmi
    Department of Surgery, Division of Cardiothoracic Surgery, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong SAR, PR China
    Eur J Cardiothorac Surg 30:846-51. 2006
    b>Bronchiolitis obliterans syndrome (BOS) is the main and late chronic complication after lung transplantation. It remains a major impediment to long-term outcome...
  42. ncbi Bronchiolitis obliterans syndrome (BOS), bronchiolitis obliterans organizing pneumonia (BOOP), and other late-onset noninfectious pulmonary complications following allogeneic hematopoietic stem cell transplantation
    Satoshi Yoshihara
    Division of Hematology, Department of Internal Medicine, Hyogo College of Medicine, Hyogo, Japan
    Biol Blood Marrow Transplant 13:749-59. 2007
    ..this review is to clarify the pathogenesis and diagnostic criteria of representative conditions, such as bronchiolitis obliterans syndrome and bronchiolitis obliterans organizing pneumonia, and to discuss the appropriate diagnostic ..
  43. ncbi Long-term azithromycin for bronchiolitis obliterans syndrome after lung transplantation
    Jens Gottlieb
    Department of Respiratory Medicine, Hannover Medical School, Hannover, Germany
    Transplantation 85:36-41. 2008
    b>Bronchiolitis obliterans syndrome (BOS) is a major cause of morbidity and mortality after lung transplantation (LTx). Macrolides are a promising treatment option for BOS...
  44. pmc Bronchiolitis obliterans following lung transplantation: early detection using computed tomographic scanning
    P A de Jong
    Department of Medicine, University of British Columbia, Vancouver, BC, Canada
    Thorax 61:799-804. 2006
    ....
  45. ncbi Bronchiolitis obliterans syndrome in lung transplant recipients: correlation of computed tomography findings with bronchiolitis obliterans syndrome stage
    Yo Won Choi
    Department of Radiology, Duke University Medical Center, Durham, NC 27710, USA
    J Thorac Imaging 18:72-9. 2003
    ..tomographic (CT) findings with the severity of respiratory dysfunction in lung transplant recipients with bronchiolitis obliterans syndrome (BOS)...
  46. ncbi Risk factors for bronchiolitis obliterans: a systematic review of recent publications
    Linda D Sharples
    Medical Research Council MRC Biostatistics Unit, University Forvie Site, Papworth Everard, Cambridge, United Kingdom
    J Heart Lung Transplant 21:271-81. 2002
    ..A thorough understanding of the factors that confer high risk of developing obliterative bronchiolitis or its physiologic surrogate bronchiolitis obliterans syndrome is important to help define therapeutic strategies.
  47. ncbi Decreased serum and bronchoalveolar lavage levels of Clara cell secretory protein (CC16) is associated with bronchiolitis obliterans syndrome and airway neutrophilia in lung transplant recipients
    Magnus Nord
    Department of Medical Nutrition, Karolinska Institute, Novum, Huddinge University Hospital, Stockholm, Sweden
    Transplantation 73:1264-9. 2002
    The major hinderance for long-term survival after lung transplantation is chronic rejection in the form of bronchiolitis obliterans syndrome (BOS). BOS is a fibrosing process in the small airways causing irreversible airway obstruction...
  48. ncbi Post-lung transplantation bronchiolitis obliterans syndrome: usefulness of expiratory thin-section CT for diagnosis
    M J Siegel
    Mallinckrodt Institute of Radiology, Washington University School of Medicine, 510 S Kingshighway Blvd, St Louis, MO 63110, USA
    Radiology 220:455-62. 2001
    ..thin-section expiratory computed tomography (CT), as compared with that of thin-section inspiratory CT, in detecting airway obstruction and air trapping in pediatric lung transplant recipients with bronchiolitis obliterans syndrome (BOS).
  49. ncbi Obliterative bronchiolitis following lung transplantation: from old to new concepts?
    Geert M Verleden
    Department of Respiratory Medicine, University Hospital Gasthuisberg, 49 Herestraat, Leuven, Belgium
    Transpl Int 22:771-9. 2009
    ..characterized by a progressive and irreversible decline in FEV(1), which is clinically defined as bronchiolitis obliterans syndrome (BOS) remains the major obstacle to long-term survival...
  50. ncbi Hidden Markov models for the onset and progression of bronchiolitis obliterans syndrome in lung transplant recipients
    Christopher H Jackson
    Medical Research Council Biostatistics Unit, Institute of Public Health, Robinson Way, Cambridge, CB4 2SR, UK
    Stat Med 21:113-28. 2002
    ..This paper describes the use of hidden Markov models for the underlying staged functional decline. Maximum likelihood methods are used to simultaneously estimate disease progression rates and the effects of mismeasurement and covariates...
  51. ncbi Activation of human airway epithelial cells by non-HLA antibodies developed after lung transplantation: a potential etiological factor for bronchiolitis obliterans syndrome
    A Jaramillo
    Department of Surgery, Washington University School of Medicine, St. Louis, MO 63110-1093, USA
    Transplantation 71:966-76. 2001
    BACKGROUND: The main cause of morbidity and mortality after lung transplantation (LT) is bronchiolitis obliterans syndrome (BOS). Anti-HLA antibodies development after LT has been shown to play an important role in BOS pathogenesis...
  52. ncbi Prognostic value of bronchoalveolar lavage neutrophilia in stable lung transplant recipients
    Claus Neurohr
    Department of Internal Medicine I, Division of Pulmonary Diseases, Klinikum Grosshadern, Ludwig Maximilians University, Munich, Germany
    J Heart Lung Transplant 28:468-74. 2009
    Bronchoalveolar lavage (BAL) neutrophilia may identify patients prone to develop bronchiolitis obliterans syndrome (BOS) after lung transplantation (LTx). This study assessed the predictive value of BAL neutrophilia in stable recipients.
  53. ncbi Utility of high resolution computed tomography in predicting bronchiolitis obliterans syndrome following lung transplantation: preliminary findings
    W T Miller
    Department of Radiology, Hospital of the University of Pennsylvania, Philadelphia, USA
    J Thorac Imaging 16:76-80. 2001
    ..to evaluate the efficacy of high resolution computed tomography (HRCT) in predicting the development of bronchiolitis obliterans syndrome (BOS) in lung transplant recipients...
  54. ncbi Bronchiolitis obliterans syndrome in heart-lung transplant recipients: diagnosis with expiratory CT
    A A Bankier
    Department of Radiology, Harvard Medical School, Boston, Massachusetts, USA
    Radiology 218:533-9. 2001
    To determine the test performance and longitudinal evolution of air trapping for diagnosing bronchiolitis obliterans syndrome (BOS).
  55. ncbi Post infectious bronchiolitis obliterans in children
    Gilberto B Fischer
    Department of Paediatrics, Universidade Federal de Ciências da Saúde, Porto Alegre, Brazil
    Paediatr Respir Rev 11:233-9. 2010
    b>Bronchiolitis Obliterans (BO) is an infrequent chronic and obstructive lung disease secondary to an insult to the terminal airway and its surroundings...
  56. ncbi Airway colonization and gastric aspiration after lung transplantation: do birds of a feather flock together?
    Robin Vos
    Laboratory of Pneumology, Katholieke Universiteit Leuven, Leuven, Belgium
    J Heart Lung Transplant 27:843-9. 2008
    ..that, due to their interaction with the epithelium, both may be involved in chronic allograft dysfunction/bronchiolitis obliterans syndrome (BOS) after LTx...
  57. ncbi Pseudomonal airway colonisation: risk factor for bronchiolitis obliterans syndrome after lung transplantation?
    R Vos
    Laboratory of Pneumology, Katholieke Universiteit Leuven, Belgium
    Eur Respir J 31:1037-45. 2008
    ..The current authors investigated whether pseudomonal colonisation affects the prevalence of bronchiolitis obliterans syndrome (BOS) after lung transplantation...
  58. ncbi Azithromycin reduces airway neutrophilia and interleukin-8 in patients with bronchiolitis obliterans syndrome
    Geert M Verleden
    Department of Respiratory Diseases, University Hospital Gasthuisberg, Leuven, Belgium
    Am J Respir Crit Care Med 174:566-70. 2006
    b>Bronchiolitis obliterans syndrome (BOS) remains the leading cause of death after lung transplantation. Treatment is difficult, although azithromycin has recently been shown to improve FEV(1). The exact mechanism of action is unclear.
  59. ncbi Azithromycin reverses airflow obstruction in established bronchiolitis obliterans syndrome
    Bryan Yates
    The William Leech Centre for Lung Research, The Freeman Hospital, High Heaton, Newcastle upon Tyne, NE7 7DN, UK
    Am J Respir Crit Care Med 172:772-5. 2005
    A recent pilot study noted clinical benefit of macrolide therapy in the management of six lung transplant recipients with bronchiolitis obliterans syndrome (BOS), a condition previously regarded as irreversible.
  60. ncbi Maintenance azithromycin therapy for bronchiolitis obliterans syndrome: results of a pilot study
    Susan G Gerhardt
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    Am J Respir Crit Care Med 168:121-5. 2003
    b>Bronchiolitis obliterans syndrome remains the leading cause of morbidity and mortality in the pulmonary transplant population...
  61. ncbi Posttransplant bronchiolitis obliterans syndrome is associated with bronchial epithelial to mesenchymal transition
    S Hodge
    Lung Research Laboratory, Hanson Institute, Adelaide, Australia
    Am J Transplant 9:727-33. 2009
    b>Bronchiolitis obliterans syndrome (BOS) compromises lung transplant outcomes and is characterised by airway epithelial damage and fibrosis...
  62. ncbi Statin use is associated with improved function and survival of lung allografts
    Bruce A Johnson
    Department of Medicine, University of Pittsburgh, 628 NW MUH, 3459 Fifth Ave, Pittsburgh, PA 15213, USA
    Am J Respir Crit Care Med 167:1271-8. 2003
    ..01). The 6-year survival of recipients taking statins (91%) was much greater than that of control subjects (54%) (p < 0.01). These data suggest statin use may have substantial clinical benefits after pulmonary transplantation...
  63. ncbi Pulmonary function in children and adolescents with postinfectious bronchiolitis obliterans
    Rita Mattiello
    Faculdade de Medicina, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brasil
    J Bras Pneumol 36:453-9. 2010
    To describe the pulmonary function in children and adolescents with postinfectious bronchiolitis obliterans (PIBO), as well as to evaluate potential risk factors for severe impairment of pulmonary function.
  64. pmc BLT1-mediated T cell trafficking is critical for rejection and obliterative bronchiolitis after lung transplantation
    Benjamin D Medoff
    Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA
    J Exp Med 202:97-110. 2005
    ..This is the first report that describes a pathologic role for BLT1-mediated T lymphocyte recruitment in disease and identifies BLT1 as a potential therapeutic target after lung transplantation...
  65. ncbi Interleukin-17 stimulates release of interleukin-8 by human airway smooth muscle cells in vitro: a potential role for interleukin-17 and airway smooth muscle cells in bronchiolitis obliterans syndrome
    Bart M Vanaudenaerde
    Laboratory of Pneumology, Catholic University Leuven, Leuven, Belgium
    J Heart Lung Transplant 22:1280-3. 2003
    b>Bronchiolitis obliterans syndrome is the major constraint on the long-term survival after lung transplantation...
  66. ncbi Primary graft dysfunction and long-term pulmonary function after lung transplantation
    Bryan A Whitson
    Department of Surgery, Division of Cardiovascular and Thoracic Surgery, University of Minnesota, Minneapolis, Minnesota 55455, USA
    J Heart Lung Transplant 26:1004-11. 2007
    ..The study's aim was to determine whether development of severe primary graft dysfunction in the perioperative period was associated with reduced long term rates of survival or with diminished long term pulmonary function...
  67. pmc Human and murine obliterative bronchiolitis in transplant
    John F McDyer
    Division of Pulmonary and Critical Care Medicine, School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA
    Proc Am Thorac Soc 4:37-43. 2007
    ....
  68. ncbi Long-term azithromycin therapy for bronchiolitis obliterans syndrome: divide and conquer?
    Robin Vos
    Laboratory of Pneumology, Katholieke Universiteit Leuven and University Hospital Gasthuisberg, Leuven, Belgium
    J Heart Lung Transplant 29:1358-68. 2010
    Azithromycin may reverse or halt the decline of pulmonary function (FEV(1)) in bronchiolitis obliterans syndrome (BOS). In this study we investigated the effects of long-term azithromycin treatment in lung transplant recipients with BOS.
  69. ncbi Early posttransplant inflammation promotes the development of alloimmunity and chronic human lung allograft rejection
    Ankit Bharat
    Department of Surgery, Washington University School of Medicine, St Louis, MO 63110, USA
    Transplantation 83:150-8. 2007
    Chronic human lung allograft rejection, represented by bronchiolitis obliterans syndrome (BOS), is the single most important factor that limits the long-term survival following lung transplantation (LT)...
  70. ncbi Aerosolized tacrolimus: a case report in a lung transplant recipient
    D Hayes
    Department of Pediatrics, University of Kentucky College of Medicine, Lexington, Kentucky 40536, USA
    Transplant Proc 42:3876-9. 2010
    Long-term outcomes after lung transplantation remain poor mainly to the development of bronchiolitis obliterans syndrome (BOS). Currently, treatment options for BOS are very limited...
  71. ncbi Epithelial to mesenchymal transition (EMT) and airway remodelling after human lung transplantation
    L A Borthwick
    Applied Immunobiology and Transplantation Research Group, Institute of Cellular Medicine, Medical School, University of Newcastle, Newcastle upon Tyne NE2 4HH, UK
    Thorax 64:770-7. 2009
    ..The potential for airway epithelium from lung transplant recipients to undergo epithelial to mesenchymal cell transition (EMT) was assessed in culture and in vivo in lung allograft tissue...
  72. ncbi Gastro-oesophageal reflux and gastric aspiration in lung transplant patients with or without chronic rejection
    K Blondeau
    Centre for Gastroenterological Research, University Hospital Gasthuisberg, Katholieke Universiteit, Leuven, Belgium
    Eur Respir J 31:707-13. 2008
    ..reflux (GOR) and gastric aspiration have been labelled as risk factors for chronic rejection bronchiolitis obliterans syndrome (BOS) after lung transplantation (LTx)...
  73. ncbi Post-transplant bronchiolitis obliterans
    A Boehler
    Division of Pulmonary Medicine, University Hospital, Zurich, Switzerland
    Eur Respir J 22:1007-18. 2003
    ..However, chronic allograft dysfunction in the form of bronchiolitis obliterans remains a major hurdle that threatens both the quality of life and long-term survival of the recipients...
  74. ncbi Impact of immediate primary lung allograft dysfunction on bronchiolitis obliterans syndrome
    Shiraz A Daud
    Division of Pulmonary and Critical Care, Washington University School of Medicine, 660 S Euclid Avenue, Campus Box 8052, St Louis, MO 63110, USA
    Am J Respir Crit Care Med 175:507-13. 2007
    ..Primary graft dysfunction is a common complication after lung transplantation and a significant risk factor for short- and long-term mortality...
  75. ncbi Bronchiolitis obliterans syndrome and survival following lung transplantation for patients with sarcoidosis
    K M Wille
    Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama 35294 0006, USA
    Sarcoidosis Vasc Diffuse Lung Dis 25:117-24. 2008
    ..Our aim was to evaluate post-transplant morbidity and survival of patients with sarcoid compared to recipients transplanted for idiopathic pulmonary fibrosis (IPF)...
  76. pmc Treatment with placenta-derived mesenchymal stem cells mitigates development of bronchiolitis obliterans in a murine model
    Yunge Zhao
    Division of Thoracic and Cardiovascular Surgery, Department of Surgery, University of Virginia Health System, Charlottesville, VA
    J Thorac Cardiovasc Surg 147:1668-1677.e5. 2014
    ..This study investigates the hypothesis that treatment with PMSCs reduces the development of bronchiolitis obliterans in a murine heterotopic tracheal transplant model.
  77. ncbi Clarithromycin for prevention of bronchiolitis obliterans syndrome in lung allograft recipients
    Gundeep S Dhillon
    Department of Medicine, Stanford University Medical Center, Stanford, CA 94305, USA
    Clin Transplant 26:105-10. 2012
    b>Bronchiolitis obliterans syndrome (BOS) is the major limitation to long-term survival following lung transplantation and strategies to reduce its incidence have remained elusive...
  78. pmc Early plasma soluble receptor for advanced glycation end-product levels are associated with bronchiolitis obliterans syndrome
    R J Shah
    Pulmonary, Allergy, and Critical Care Division, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Am J Transplant 13:754-9. 2013
    Early epithelial injury after lung transplantation may contribute to development of bronchiolitis obliterans syndrome (BOS)...
  79. ncbi Matrix metalloproteinase-9 in bronchiolitis obliterans syndrome after lung transplantation
    R H Hübner
    Dept of Internal Medicine, University Hospital Schleswig Holstein, Campus Kiel, Schittenhelmstr 12, 24105 Kiel, Germany
    Eur Respir J 25:494-501. 2005
    b>Bronchiolitis obliterans syndrome (BOS) is a severe complication after lung transplantation (LTX)...
  80. ncbi Conversion from cyclosporine to tacrolimus stabilizes the course of lung function in lung transplant recipients with bronchiolitis obliterans syndrome
    J M Borro
    Hospital Juan Canalejo, A Coruna, Spain
    Transplant Proc 39:2416-9. 2007
    b>Bronchiolitis obliterans syndrome (BOS) continues to be the main factor limiting the long-term survival of lung transplant recipients...
  81. ncbi High-dose corticosteroid therapy for bronchiolitis obliterans after bone marrow transplantation in children
    F Ratjen
    Department of Paediatrics, Children s Hospital, University of Essen, Essen, Germany
    Bone Marrow Transplant 36:135-8. 2005
    b>Bronchiolitis obliterans (BO) is a rare but serious complication of paediatric allogenic bone marrow transplantation (BMT)...
  82. pmc Role of CXCR2/CXCR2 ligands in vascular remodeling during bronchiolitis obliterans syndrome
    John A Belperio
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California 90095, USA
    J Clin Invest 115:1150-62. 2005
    ..has addressed the importance of angiogenesis during fibro-obliteration of the allograft airway during bronchiolitis obliterans syndrome (BOS) that occurs after lung transplantation...
  83. ncbi Histopathological bronchial reconstruction of human bronchiolitis obliterans
    Keishi Sugino
    Department of Respiratory Medicine, Toho University Omori Medical Center, Tokyo, Japan
    Pathol Int 61:192-201. 2011
    To clarify the morphological mechanisms of airway obliteration in bronchiolitis obliterans (BO) associated with various causes, we conducted a retrospective study of 9 patients with a histological diagnosis of BO...
  84. ncbi Effectiveness of magnetic resonance angiography in the evaluation of lung perfusion in constrictive bronchiolitis obliterans
    Ozge Yilmaz
    Department of Pediatric Allergy and Pulmonology, Celal Bayar University, Manisa, Turkey
    Respirology 14:295-8. 2009
    Childhood constrictive bronchiolitis obliterans (CBO) is characterized clinically by the persistence of obstructive respiratory symptoms following a prolonged episode of lower respiratory viral infection...
  85. ncbi Clinical significance of lung perfusion defects in children with post-infectious bronchiolitis obliterans
    Hasan Yuksel
    Department of Pediatric Allergy and Pulmonology, Faculty of Medicine, Celal Bayar University, Manisa, Turkey
    Tuberk Toraks 57:376-82. 2009
    Clinical significance of segmental lung perfusion defects in children with bronchiolitis obliterans (BO), have not been reported before...
  86. pmc The presence of a matrix-derived neutrophil chemoattractant in bronchiolitis obliterans syndrome after lung transplantation
    Matthew T Hardison
    Department of Physiology and Biophysics, University of Alabama at Birmingham, 35294, USA
    J Immunol 182:4423-31. 2009
    ..Unfortunately, lung transplant recipients have poor clinical outcomes, often due to the development of bronchiolitis obliterans syndrome (BOS)...
  87. ncbi Bronchiolitis obliterans syndrome development in lung transplantation patients
    M T Parada
    Lung Transplant Program, Clinica Las Condes, Santiago, Chile
    Transplant Proc 42:331-2. 2010
    The main cause of death in lung transplantation patients is chronic rejection, known as bronchiolitis obliterans syndrome (BOS). There are many variables associated with its appearance...
  88. ncbi Functional capacity assessment in children and adolescents with post-infectious bronchiolitis obliterans
    Rita Mattiello
    Universidade Federal do Rio Grande do Sul UFRGS, Porto Alegre, RS, Brazil
    J Pediatr (Rio J) 84:337-43. 2008
    To assess functional capacity during exercise in children and adolescents with post-infectious bronchiolitis obliterans (PIBO).
  89. ncbi Post-infectious bronchiolitis obliterans: can CT scan findings at early age anticipate lung function?
    Rita Mattiello
    Post Grad Program in Pediatrics, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil
    Pediatr Pulmonol 45:315-9. 2010
    The image findings of post-infectious bronchiolitis obliterans (PIBO) have been described, however, we do not know if such findings can predict lung function (LF) deterioration with increasing patient age.
  90. ncbi Bronchiolitis obliterans syndrome: alloimmune-dependent and -independent injury with aberrant tissue remodeling
    Masaaki Sato
    Latner Thoracic Surgery Research Laboratories, Toronto General Research Institute, University Health Network, University of Toronto, Toronto, Ontario, Canada
    Semin Thorac Cardiovasc Surg 20:173-82. 2008
    ..in lung transplantation continues to be challenged by chronic graft dysfunction, which is manifest as bronchiolitis obliterans syndrome (BOS)...
  91. ncbi [Postinfectious bronchiolitis obliterans]
    Alejandro J Colom
    Centro Respiratorio, Hospital de Niños Dr Ricardo Gutierrez, Buenos Aires
    Arch Argent Pediatr 107:160-7. 2009
    b>Bronchiolitis obliterans is an uncommon and severe form of chronic obstructive lung disease that results from an insult to the lower respiratory tract...
  92. ncbi Lung transplantation, gastroesophageal reflux, and fundoplication
    Andrew G N Robertson
    Northern Oesophago Gastric Unit, Royal Victoria Infirmary, Newcastle, United Kingdom
    Ann Thorac Surg 89:653-60. 2010
    Lung transplantation is an accepted treatment strategy for end-stage lung disease; however, bronchiolitis obliterans syndrome is a major cause of morbidity and mortality...
  93. ncbi Bronchiolitis obliterans following hematopoietic stem cell transplantation: a clinical update
    Chirag M Pandya
    Division of Pulmonary, Critical Care and Sleep Medicine, Karmanos Cancer Center and Wayne State University School of Medicine, Detroit, MI 48201, USA
    Clin Transplant 24:291-306. 2010
    ..Currently, bronchiolitis obliterans is one of the most challenging pulmonary complications facing clinicians who are taking care of HSCT ..
  94. ncbi Bronchiolitis obliterans in children
    Geoffrey Kurland
    Division of Pediatric Pulmonology, Children s Hospital of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Pediatr Pulmonol 39:193-208. 2005
    b>Bronchiolitis obliterans (BO) in children is a relatively rare diagnosis...
  95. ncbi Influenza pneumonia in lung transplant recipients: clinical features and association with bronchiolitis obliterans syndrome
    S Garantziotis
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Chest 119:1277-80. 2001
    ..Additional research, therefore, is needed to clarify the relationship between influenza infection, acute rejection, and obliterative bronchiolitis...
  96. ncbi Postinfectious bronchiolitis obliterans in children: clinical and radiological profile and prognostic factors
    Ebru Yalcin
    Chest Diseases Unit, Department of Pediatrics, Hacettepe University Faculty of Medicine, Ankara, Turkey
    Respiration 70:371-5. 2003
    Postinfectious bronchiolitis obliterans (BO) designates a clinical syndrome of chronic airflow obstruction associated with inflammatory changes in the small airways.
  97. ncbi Interleukin-1 receptor antagonist as a biomarker for bronchiolitis obliterans syndrome in lung transplant recipients
    John A Belperio
    Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, Henry Ford Hospital, Detroit, MI 48208, USA
    Transplantation 73:591-9. 2002
    ..Interleukin-1 receptor antagonist (IL-1Ra) is a naturally occurring antagonist of the pro-inflammatory cytokine IL-1 and has been associated with a number of fibroproliferative diseases...
  98. ncbi Rapid acute onset of bronchiolitis obliterans syndrome in a lung transplant recipient after respiratory syncytial virus infection
    D Hayes
    The Ohio State University, Columbus, Ohio 43205, USA
    Transpl Infect Dis 14:548-50. 2012
    b>Bronchiolitis obliterans syndrome (BOS) can have either an acute or chronic onset with an abrupt or insidious course...
  99. ncbi Association between donor MBL promoter haplotype and graft survival and the development of BOS after lung transplantation
    Janna M Munster
    Department of Internal Medicine, University Medical Center Groningen, Groningen, The Netherlands
    Transplantation 86:1857-63. 2008
    ..In this study, the effect of donor- and recipient-MBL genotype on lung transplant outcome was investigated...
  100. ncbi Obliterative bronchiolitis after lung transplantation: a repetitive multiple injury airway disease
    Jim J Egan
    Am J Respir Crit Care Med 170:931-2. 2004
  101. ncbi High levels of mannose-binding lectin are associated with poor outcomes after lung transplantation
    Katherine E Carroll
    Department of Respiratory Medicine St Vincent s Hospital, Victoria, Australia
    Transplantation 91:1044-9. 2011
    ..Genetic mutations of MBL are common, result in low serum levels of MBL, and are associated with increased infection risk in solid-organ transplant recipients...

Research Grants62

  1. PATHOGENESIS OF POST-TRANSPLANT BRONCHIOLITIS OBLITERANS
    Thalachallour Mohanakumar; Fiscal Year: 2004
    ..However, the long term survival of the lung allograft are limited by the development of bronchiolitis obliterans syndrome (BOS) an unexplained and irreversible condition unresponsive to therapy and in most cases fatal...
  2. Immune Mechanism of Rejection in Human Lung Allografts
    Thalachallour Mohanakumar; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Chronic rejection, clinically diagnosed as Bronchiolitis obliterans Syndrome (BOS), is the most significant long term cause of morbidity and mortality following human lung transplantation (LTx)...
  3. Role of TLR-4 in Lung Reperfusion Injury
    MICHAEL SCOTT MULLIGAN; Fiscal Year: 2013
    ..recipients and leads to enhanced MHC class II expression, acute graft dysfunction, earlier onset of bronchiolitis obliterans and increased recipient mortality...
  4. The Role of Complement in Airway Microvascular Disease
    MARK ROBERT NICOLLS; Fiscal Year: 2013
    ..vasculature in lung allografts may be critical for preventing terminal airway fibrosis, also known as the bronchiolitis obliterans syndrome...
  5. Eicosanoid Balance in Lung Transplant Injury and Repair
    David Pinsky; Fiscal Year: 2009
    ..lung graft failure occurs in up to 20% of recipients, and by 5 years, over half of all patients develop bronchiolitis obliterans (BO), the major cause of death outside of infections...
  6. Role of epithelial HLA-G in lung transplantation
    Steven R White; Fiscal Year: 2010
    ..Chronic allograft rejection (bronchiolitis obliterans syndrome, or BOS) is the major limitation to long-term survival, yet its pathogenesis is poorly ..
  7. Whole Genome Association Analysis of Hematopoietic Cell Transplant (HCT) Outcome
    JOHN ANDREW HANSEN; Fiscal Year: 2013
    ..analyzed will include acute and chronic GVHD, immunological tolerance, airflow obstruction (AFO disease/bronchiolitis obliterans syndrome (BOS), acute kidney injury (AKI), Gram negative bacteremia, invasive fungal disease, CMV ..
  8. Novel Cellular Immune Profiles to Predict Lung Disease Outcomes
    Scott M Palmer; Fiscal Year: 2012
    ..Our application focuses on bronchiolitis obliterans syndrome (BOS), a fibrotic disease that occurs after human lung transplantation and is the primary reason ..
  9. Bronchoalveolar Lavage Cell Biomarkers in Lung Rejection
    Marshall I Hertz; Fiscal Year: 2010
    ..of kidney, heart, and liver recipients, largely due to the effects of acute and chronic lung rejection (bronchiolitis obliterans syndrome, BOS)...
  10. Studies to Evaluate the Toxic Carcinogenic Potential of Test Agents
    JEFFERY DILL; Fiscal Year: 2009
    ..ABAs have been linked to occupational exposure and human health effects including bronchiolitis obliterans. Animal studies are neede to determine the potential for human health effects to individual ABAs...
  11. SP-D as an immunomodulatory protein in acute rejection in lung transplantation
    KAREN D SIMS; Fiscal Year: 2010
    ..rejection (ACR) affects 50% of recipients in the first year, and is a risk factor for the development of bronchiolitis obliterans syndrome, the leading cause of death in lung transplant recipients...
  12. Role of T Regulatory Cells in Preventing Human BOS
    Aric L Gregson; Fiscal Year: 2013
    ..Long-term survival is largely dependent upon recipients remaining free of bronchiolitis obliterans syndrome (BOS)...
  13. ALLOANTIBODIES TO MHC INDUCES AUTOIMMUNITY AND OBLITERATIVE AIRWAY DISEASE (OAD)
    Thalachallour Mohanakumar; Fiscal Year: 2012
    ..However, long-term survival of the lung allograft is limited by the development of bronchiolitis obliterans syndrome (BOS), a condition unresponsive to therapy and often fatal...
  14. Genetic Analysis of Airflow Obstruction After Stem Cell Transplantation
    Joan G Clark; Fiscal Year: 2013
    ..Known as bronchiolitis obliterans syndrome in its severest form, this syndrome is now estimated to affect up to 26% of patients who receive ..
  15. Studies to Evaluate the Toxic Carcinogenic Potential of Test Agents
    JEFFERY DILL; Fiscal Year: 2010
    ..ABAs have been linked to occupational exposure and human health effects including bronchiolitis obliterans. Animal studies are needed to determine the potential for human health effects to individual ABAs...
  16. Studies to Evaluate the Toxic Carcinogenic Potential of Test Agents
    JEFFERY DILL; Fiscal Year: 2011
    ..ABAs have been linked to occupational exposure and human health effects including bronchiolitis obliterans. Animal studies are needed to determine the potential for human health effects to individual ABAs...
  17. INNATE IMMUNE REGULATION OF PRIMARY GRAFT DYSFUNCTION
    Howard J Huang; Fiscal Year: 2013
    ..Importantly, PGD is also a risk factor for developing Bronchiolitis Obliterans Syndrome, the main cause of late graft failure and death in this population...
  18. TREATMENT OF ANTI-HLA ANTIBODIES TO PREVENT BOS AFTER LUNG TRANSPLANTATION
    Roger D Yusen; Fiscal Year: 2011
    DESCRIPTION (provided by applicant): Chronic rejection or bronchiolitis obliterans syndrome (BOS) has emerged as the primary obstacle to long- term survival after lung transplantation...
  19. Adenosine 2A Receptor Signaling in Lung Transplant Injury and Rejection
    Christine L Lau; Fiscal Year: 2013
    ..Importantly, IRI is a significant risk factor for the development of chronic allograft rejection, bronchiolitis obliterans (BO). Evidence supports alloimmune-dependent and alloimmune-independent factors in the etiology BO...
  20. Research on inhalation toxicology of environmental chemicals
    ROBERT O apos CONNER; Fiscal Year: 2010
    ..Recent work includes studies of bronchiolitis obliterans caused by inhalation of artificial butter flavoring components, mechanisms of pleural fibrosis caused of ..
  21. Research on inhalation toxicology of environmental chemicals
    ROBERT O'CONNER; Fiscal Year: 2011
    ..Recent work includes studies of bronchiolitis obliterans caused by inhalation of artificial butter flavoring components, mechanisms of pleural fibrosis caused of ..
  22. Host Defense Mechanisms in Chronic Lung Disease
    Jo Rae Wright; Fiscal Year: 2010
    ..consists of four interrelated research projects that are focused on two chronic lung diseases: asthma and bronchiolitis obliterans syndrome (BOS) with a common underlying theme of epithelial injury, inflammation, repair and ..
  23. Elafin Therapy for Lung Diseases
    Marlene Rabinovitch; Fiscal Year: 2013
    ..the microcirculation in the murine tracheal transplant model, and prevent airway ischemia associated with bronchiolitis obliterans. This project further investigates the efficacy of combining elafin with low dose immunosuppression or of ..
  24. Development of CMV-specific T Cell Memory in Lung Transplant Recipients
    John F McDyer; Fiscal Year: 2012
    ..Active CMV infection is associated with acute and chronic rejection (bronchiolitis obliterans syndrome), with donor+/recipient- (D+R-) mismatched lung transplant recipients (LTRs) at highest risk for ..
  25. Research on inhalation toxicology of environmental chemicals
    ROBERT O apos CONNER; Fiscal Year: 2009
    ..Recent work includes studies of bronchiolitis obliterans caused by inhalation of artificial butter flavoring components, mechanisms of pleural fibrosis caused of ..
  26. Immune Mediated Disorders After Allogeneic Hematopoietic Cell Transplants (HCT)
    Stephanie J Lee; Fiscal Year: 2010
    ..but poorly understood syndromes with particularly high morbidity/mortality: cutaneous sclerosis, bronchiolitis obliterans syndrome and late acute GVHD...
  27. Immune Mediated Disorders After Allogeneic Hematopoietic Cell Transplants (HCT)
    Stephanie J Lee; Fiscal Year: 2013
    ..but poorly understood syndromes with particularly high morbidity/mortality: cutaneous sclerosis, bronchiolitis obliterans syndrome and late acute GVHD...
  28. Indoleamine 2,3-dioxygenase protective role in lung transplantation
    Gary A Visner; Fiscal Year: 2010
    ..Acute and chronic rejection/bronchiolitis obliterans (BO) are major limiting factors for long-term lung allograft survival with chronic rejection coming from ..
  29. A Critical Role for the Microvasculature in Airway Transplantation
    MARK ROBERT NICOLLS; Fiscal Year: 2013
    ..in lung allografts could be key for preventing terminal airway fibrosis, also known as the bronchiolitis obliterans syndrome (BOS)...
  30. IL-17 and Lung Transplant Obliterative Bronchiolitis
    Rebecca A Shilling; Fiscal Year: 2013
    ..for lung transplant patients is much lower compared to other solid organs due to the late complication of bronchiolitis obliterans syndrome for which there is no effective treatment...
  31. Mentored Patient Oriented Research in Lung Transplantation
    Jason D Christie; Fiscal Year: 2013
    ..pre- operatively, and that these molecular mechanisms of lung injury in PGD are linked to subsequent bronchiolitis obliterans syndrome (BOS) risk...
  32. Signaling Pathways Regulating Serum Response Factor in Pulmonary Fibrosis
    NATHAN K SANDBO; Fiscal Year: 2013
    ..signaling to the study of basic mechanisms of fibrotic human diseases, such as pulmonary fibrosis and bronchiolitis obliterans. Dr. Nickolai Dulin will mentor the principal investigator's scientific development...
  33. The Role of Aspergillus in the Pathogenesis of Bronchiolitis Obliterans Syndrome
    Stephen S Weigt; Fiscal Year: 2013
    ..Chronic lung allograft rejection, also known as bronchiolitis obliterans syndrome (BOS), is the most important factor limiting long term survival in lung transplant recipients...
  34. Lung Transplant Microbiome and Chronic Allograft Dysfunction
    Ronald G Collman; Fiscal Year: 2013
    ..the only long-term option for many end stage lung diseases, but chronic allograft dysfunction manifest as bronchiolitis obliterans syndrome (BOS) develops in e50% of recipients by 5 years and is the principal barrier to long term ..
  35. Progenitor Cells in Airway Repair
    Brigitte N Gomperts; Fiscal Year: 2013
    ..lung transplantation is associated with numerous serious complications including acute rejection and bronchiolitis obliterans syndrome (BOS)...
  36. Role of resident mesenchymal stem cells in lung allograft rejection
    Vibha N Lama; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Chronic rejection or bronchiolitis obliterans (BO) continues to be the major impediment to long-term survival after lung transplantation...
  37. Immune Mechanisms of Alloinjury
    John A Belperio; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Chronic lung allograft rejection, also known as bronchiolitis obliterans syndrome (BOS), is an inflammatory process that ends in fibro-obliteration of the allograft airways;however the exact mechanism(..
  38. B-CELL TARGETED INDUCTION TO IMPROVE OUTCOMES IN PEDIATRIC LUNG TRANSPLANTATION
    Stuart C Sweet; Fiscal Year: 2013
    ..clinical cohort (N=50) to test whether rituximab induction will improve a composite clinical endpoint of bronchiolitis obliterans, death, and re-transplantation...
  39. Nasal dosimetry of diacetyl and butyric acid vapors
    John Morris; Fiscal Year: 2005
    ..generally recognized as safe as food additives, exposure of workers to these vapors is associated with bronchiolitis obliterans. It has recently been shown that inhalation exposure of the rat to butter flavoring vapors results in ..
  40. Viral-Driven Mediators of Chronic Lung Allograft Dysfunction
    Richard Pierce; Fiscal Year: 2009
    b>Bronchiolitis obliterans (BO) following lung transplantation is a chronic disease associated with increased morbidity and mortality...
  41. EFFECT OF DENERVATION ON THE FUNCTION OF THE AIRWAYS
    J PEREZ FONTAN; Fiscal Year: 2004
    ..tachykinin amplification of immune-mediated inflammation of the lungs and airways in disease processes such as bronchiolitis obliterans after lung transplantation or hyperoxic/stretch injury after mechanical ventilation.
  42. Nitration immunology
    John Hunt; Fiscal Year: 2005
    ..inflammatory lung diseases including asthma, chronic obstructive pulmonary disease, cystic fibrosis, and bronchiolitis obliterans. Formation of nitrotyrosine occurs inorganically, but also is catalyzed by enzymes of polymorphonuclear ..
  43. CMV Replication During Primary Infection in Lung Transplant Recipients
    John McDyer; Fiscal Year: 2009
    ..is associated with acute rejection episodes and is a recognized risk factor for chronic rejection (bronchiolitis obliterans syndrome) through poorly understood mechanisms...
  44. Genetic Risk Factors for Airflow Obstruction after HSCT
    Joan Clark; Fiscal Year: 2003
    b>Bronchiolitis obliterans syndrome (BOS), a clinical syndrome of irreversible, progressive airway disease causing obstructive lung disease (OLD), is a serious complication of hematopoietic stem cell transplant (HSCT)...
  45. Pathogen Discovery in Chronic Lung Disease by Mass Tag PCR and Microarray
    W Ian Lipkin; Fiscal Year: 2009
    ..linked to infection: idiopathic pulmonary fibrosis (IFF), pulmonary arterial hypertension (PAH), and bronchiolitis obliterans syndrome (BOS)...
  46. Pathogenesis and Therapy of Chronic Lung Rejection
    Marshall Hertz; Fiscal Year: 2005
    ..part, to the development of chronic lung rejection, manifested histologically as OB, and clinically as bronchiolitis obliterans syndrome (BOS)...
  47. PATHOGENESIS OF VIRAL PROLIFERATIVE BRONCHIOLITIS
    Lucille London; Fiscal Year: 2002
    DESCRIPTION (Adapted from the applicant's abstract): Bronchiolitis obliterans with organizing pneumonia (BOOP) is a term for a long observed, but unclassified pattern of acute lung injury...
  48. CYTOKINE/VIRAL GENE INTERACTIONS IN VIRAL LUNG DISEASE
    Joel Kline; Fiscal Year: 1999
    ..Disorders associated with latent infection by these pathogens may include bronchiolitis obliterans, bronchiectasis, the hyperlucent lung syndrome and other forms of chronic obstructive lung disease, and ..
  49. TRANSGENIC MOUSE MODEL OF BRONCHIOLITIS OBLITERANS
    Stuart Sweet; Fiscal Year: 2000
    ..The funds provided by this award will facilitate Dr. Sweets's development into an independent scientist. ..
  50. Lung Alloimmunity after Bone Marrow Transplantation
    Karen Wood; Fiscal Year: 2009
    Late onset pulmonary complications (bronchiolitis obliterans and interstitial pneumonia) are a significant cause of morbidity and mortality after bone marrowtransplantation. Their development correlates with a switch" in immune phenotype...
  51. Role of CXCR3 in Th1-Mediated Lung Injury
    ANNE MANICONE; Fiscal Year: 2004
    CXCR3 and its ligands are associated with Th1-related responses including allograft rejection and bronchiolitis obliterans. Reduced allograft rejection in CXCR3 knockout mice (KO) suggests an important and non-redundant role of this ..
  52. Chemokines in lung transplantation
    BENJAMIN MEDOFF; Fiscal Year: 2007
    ..These immune mediated injuries contribute to the development of scarring of the airways, so called bronchiolitis obliterans (BO)...
  53. Innate Immune Responses in Obliterative Bronchiolitis
    Scott Palmer; Fiscal Year: 2006
    ..research is to understand how innate immune responses contribute to the development of posttransplant bronchiolitis obliterans syndrome (BOS)...
  54. The Role of Chemokines During Lung Allograft Dysfunction
    John Belperio; Fiscal Year: 2009
    ..Importantly, early allograft dysfunction is a significant risk factor for the development of bronchiolitis obliterans syndrome (BOS)...
  55. CHEMOKINE BIOLOGY IN BRONCHIOLITIS OBLITERANS SYNDROME
    John Belperio; Fiscal Year: 2005
    Adapted from applicant's abstract) Chronic lung allograft rejection, Bronchiolitis Obliterans Syndrome (BOS) is a chronic process that demonstrates features of dysregulated and aberrant repair of airways...
  56. Fibroproliferation in Bronchiolitis Obliterans Syndrome
    Vibha Lama; Fiscal Year: 2008
    b>Bronchiolitis Obliterans Syndrome (BOS) is the major cause of mortality after lung transplantation...
  57. PATHOGENESIS OF POST-TRANSPLANT BRONCHIOLITIS OBLITERANS
    Thalachallour Mohanakumar; Fiscal Year: 2008
    ..However, long-term survival of the lung allograft is limited by the development of bronchiolitis obliterans syndrome (BOS), a condition unresponsive to therapy and in most cases fatal...
  58. Innovative Methods for Immune Tolerance in Lung Transpl*
    David Wilkes; Fiscal Year: 2003
    ..The leading cause of death in lung allograft recipients is chronic rejection known as bronchiolitis obliterans (BO), and repeated acute rejection episodes are believed to culminate in BO...
  59. Genetic epidemiology of TLR4 alleles and bacteremia
    Jason Chien; Fiscal Year: 2006
    ..Ultimately, this cohort of patients will be developed in anticipation of future genetic discoveries in the complicated pathway of pathogen recognition and host inflammatory response. ..
  60. MMPs in Alloimmune and Autoimmune Lung Disease
    David Wilkes; Fiscal Year: 2008
    ..The ultimate goal of these studies is to identify novel targets for therapeutic intervention for patients suffering from lung allograft rejection and autoimmune lung disease. ..
  61. MECHANISMS CAUSING PULMONARY XENOGRAFT INJURY
    R Davis; Fiscal Year: 2004
    ..Strategies developed from these studies should form the basis for the application of pulmonary xenotransplantation to the treatment of patients with pulmonary failure. ..