adult respiratory distress syndrome

Summary

Summary: A syndrome of life-threatening progressive pulmonary insufficiency in the absence of known pulmonary disease, usually following a systemic insult such as SURGERY or major TRAUMA.

Top Publications

  1. ncbi Incidence and outcomes of acute lung injury
    Gordon D Rubenfeld
    Division of Pulmonary and Critical Care Medicine, Harborview Medical Center, Seattle, WA 98104 2499, USA
    N Engl J Med 353:1685-93. 2005
  2. ncbi Role of inflammatory mediators in the pathophysiology of acute respiratory distress syndrome
    Madhav Bhatia
    Department of Pharmacology, National University of Singapore, Singapore
    J Pathol 202:145-56. 2004
  3. ncbi Future research directions in acute lung injury: summary of a National Heart, Lung, and Blood Institute working group
    Michael A Matthay
    Division of Lung Diseases, National Heart, Lung, and Blood Institute NIH, Bethesda, MD, USA
    Am J Respir Crit Care Med 167:1027-35. 2003
  4. ncbi Efficacy and safety of corticosteroids for persistent acute respiratory distress syndrome
    Kenneth P Steinberg
    Division of Pulmonary and Critical Care Medicine, Harborview Medical Center, Box 359762, 325 Ninth Ave, Seattle, WA 98104, USA
    N Engl J Med 354:1671-84. 2006
  5. ncbi Protein kinase C modulates pulmonary endothelial permeability: a paradigm for acute lung injury
    Alma Siflinger-Birnboim
    Research Service, Stratton Veterans Affairs Medical Center and the Center for Cardiovascular Science, The Albany Medical College, Albany, New York 12208, USA
    Am J Physiol Lung Cell Mol Physiol 284:L435-51. 2003
  6. ncbi Cytokine balance in the lungs of patients with acute respiratory distress syndrome
    W Y Park
    Section of Pulmonary/Critical Care Medicine, Harborview Medical Center, Medical Research Service of the VA Puget Sound Health Care System, Seattle, Washington, USA
    Am J Respir Crit Care Med 164:1896-903. 2001
  7. pmc Receptor for advanced glycation end-products is a marker of type I cell injury in acute lung injury
    Tokujiro Uchida
    Department of Anesthesiology, Graduate School of Medicine, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8519, Japan
    Am J Respir Crit Care Med 173:1008-15. 2006
  8. ncbi Neutrophil activation and acute lung injury
    W L Lee
    Division of Respirology, Department of Medicine and Critical Care Medicine Program, University of Toronto, Ontario, Canada
    Curr Opin Crit Care 7:1-7. 2001
  9. ncbi Incidence and mortality of acute lung injury and the acute respiratory distress syndrome in three Australian States
    Andrew D Bersten
    Department of Critical Care Medicine, Flinders Medical Centre, and the Intensive Care Unit, The Queen Elizabeth Hospital, Adelaide, South Australia
    Am J Respir Crit Care Med 165:443-8. 2002
  10. ncbi Comparative diagnostic performances of auscultation, chest radiography, and lung ultrasonography in acute respiratory distress syndrome
    Daniel Lichtenstein
    Réanimation Chiruricale Pierre Viars, Department of Anesthesiology, Hopital de la Pitie Salpetriere, Université Pierre et Marie Cuire, Paris IV, France
    Anesthesiology 100:9-15. 2004

Detail Information

Publications284 found, 100 shown here

  1. ncbi Incidence and outcomes of acute lung injury
    Gordon D Rubenfeld
    Division of Pulmonary and Critical Care Medicine, Harborview Medical Center, Seattle, WA 98104 2499, USA
    N Engl J Med 353:1685-93. 2005
    ..Despite recent advances in our understanding of the mechanism and treatment of acute lung injury, its incidence and outcomes in the United States have been unclear...
  2. ncbi Role of inflammatory mediators in the pathophysiology of acute respiratory distress syndrome
    Madhav Bhatia
    Department of Pharmacology, National University of Singapore, Singapore
    J Pathol 202:145-56. 2004
    ..It is reasonable to speculate that elucidation of the key mediators in ARDS coupled with the discovery of specific inhibitors would make it possible to develop clinically effective anti-inflammatory therapy...
  3. ncbi Future research directions in acute lung injury: summary of a National Heart, Lung, and Blood Institute working group
    Michael A Matthay
    Division of Lung Diseases, National Heart, Lung, and Blood Institute NIH, Bethesda, MD, USA
    Am J Respir Crit Care Med 167:1027-35. 2003
    ..Cellular and molecular methods combined with animal and clinical studies should lead to further progress in the detection and treatment of this complex disease...
  4. ncbi Efficacy and safety of corticosteroids for persistent acute respiratory distress syndrome
    Kenneth P Steinberg
    Division of Pulmonary and Critical Care Medicine, Harborview Medical Center, Box 359762, 325 Ninth Ave, Seattle, WA 98104, USA
    N Engl J Med 354:1671-84. 2006
    ..Because previous reports suggested that corticosteroids may improve survival, we performed a multicenter, randomized controlled trial of corticosteroids in patients with persistent ARDS...
  5. ncbi Protein kinase C modulates pulmonary endothelial permeability: a paradigm for acute lung injury
    Alma Siflinger-Birnboim
    Research Service, Stratton Veterans Affairs Medical Center and the Center for Cardiovascular Science, The Albany Medical College, Albany, New York 12208, USA
    Am J Physiol Lung Cell Mol Physiol 284:L435-51. 2003
    ..We conclude that PKC, most likely PKC-alpha, is a primary supporter for lung endothelial injury in response to alpha-thrombin, TNF-alpha, and reactive oxygen species...
  6. ncbi Cytokine balance in the lungs of patients with acute respiratory distress syndrome
    W Y Park
    Section of Pulmonary/Critical Care Medicine, Harborview Medical Center, Medical Research Service of the VA Puget Sound Health Care System, Seattle, Washington, USA
    Am J Respir Crit Care Med 164:1896-903. 2001
    ..This significant antiinflammatory response early in ARDS may provide a key mechanism for limiting the net inflammatory response in the lungs...
  7. pmc Receptor for advanced glycation end-products is a marker of type I cell injury in acute lung injury
    Tokujiro Uchida
    Department of Anesthesiology, Graduate School of Medicine, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8519, Japan
    Am J Respir Crit Care Med 173:1008-15. 2006
    ..Receptor for advanced glycation end-products (RAGE) is one of the alveolar type I cell-associated proteins in the lung...
  8. ncbi Neutrophil activation and acute lung injury
    W L Lee
    Division of Respirology, Department of Medicine and Critical Care Medicine Program, University of Toronto, Ontario, Canada
    Curr Opin Crit Care 7:1-7. 2001
    ..An increased understanding of how neutrophils function will facilitate the design of therapeutic strategies that retain the beneficial aspects of the inflammatory response, while avoiding unnecessary tissue damage...
  9. ncbi Incidence and mortality of acute lung injury and the acute respiratory distress syndrome in three Australian States
    Andrew D Bersten
    Department of Critical Care Medicine, Flinders Medical Centre, and the Intensive Care Unit, The Queen Elizabeth Hospital, Adelaide, South Australia
    Am J Respir Crit Care Med 165:443-8. 2002
    ....
  10. ncbi Comparative diagnostic performances of auscultation, chest radiography, and lung ultrasonography in acute respiratory distress syndrome
    Daniel Lichtenstein
    Réanimation Chiruricale Pierre Viars, Department of Anesthesiology, Hopital de la Pitie Salpetriere, Université Pierre et Marie Cuire, Paris IV, France
    Anesthesiology 100:9-15. 2004
    ..Clinical experience suggests that the diagnostic accuracy of these procedures is poor...
  11. ncbi Elevated plasma levels of soluble TNF receptors are associated with morbidity and mortality in patients with acute lung injury
    Polly E Parsons
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, Fletcher Allen Health Care, University of Vermont, Burlington, Vermont 05401, USA
    Am J Physiol Lung Cell Mol Physiol 288:L426-31. 2005
    ..Furthermore, LTVV is associated with a specific decrease in sTNFRI levels. This suggests that one beneficial effect of LTVV may be to attenuate alveolar epithelial injury...
  12. pmc Plasma surfactant protein levels and clinical outcomes in patients with acute lung injury
    M D Eisner
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of California San Francisco, 94117, USA
    Thorax 58:983-8. 2003
    ....
  13. ncbi Acute lung injury and the acute respiratory distress syndrome: a clinical review
    Arthur P Wheeler
    Medical Intensive Care Unit, Vanderbilt University Medical Center, Nashville, TN 37232 2650, USA
    Lancet 369:1553-64. 2007
    ..Refinements in ventilator and fluid management supported by data from prospective randomised trials have increased the methods available to effectively manage this disorder...
  14. ncbi Neutrophils and acute lung injury
    Edward Abraham
    Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Health Sciences Center, Denver, CO, USA
    Crit Care Med 31:S195-9. 2003
    ..This discussion aims to review the contribution of neutrophils to the development and progression of ALI and to highlight the major intracellular signaling pathways that are involved in neutrophil activation in the setting of ALI...
  15. ncbi Significant involvement of CCL2 (MCP-1) in inflammatory disorders of the lung
    C Edward Rose
    Division of Pulmunory and Critical Care Medicine and the Division of Rheumatology and Immunology, University of Virginia School of Medicine, Charlottesville, VA 22908, USA
    Microcirculation 10:273-88. 2003
    ....
  16. pmc Effects of salbutamol on exhaled breath condensate biomarkers in acute lung injury: prospective analysis
    Oriol Roca
    Intensive Care Department General Area, Hospital Universitari Vall d Hebron, Pg Vall d Hebron 119 129, C P 08035 Barcelona, Spain
    Crit Care 12:R72. 2008
    ..Biomarkers in exhaled breath condensate (EBC) were used to study the effects of salbutamol on lung inflammation in mechanically ventilated patients with ALI...
  17. pmc Comparison of functional residual capacity and static compliance of the respiratory system during a positive end-expiratory pressure (PEEP) ramp procedure in an experimental model of acute respiratory distress syndrome
    Bernard Lambermont
    Hemodynamic Research Center, HemoLiege, University of Liege, Belgium
    Crit Care 12:R91. 2008
    ....
  18. ncbi Characteristics and outcomes in adult patients receiving mechanical ventilation: a 28-day international study
    Andres Esteban
    Unidad de Cuidados Intensivos, Hospital Universitario de Getafe, Carretera de Toledo Km 12, 5, 28905 Getafe, Madrid, Spain
    JAMA 287:345-55. 2002
    ..The outcome of patients receiving mechanical ventilation for particular indications has been studied, but the outcome in a large number of unselected, heterogeneous patients has not been reported...
  19. pmc Clinical review: a paradigm shift: the bidirectional effect of inflammation on bacterial growth. Clinical implications for patients with acute respiratory distress syndrome
    G Umberto Meduri
    Divisions of Pulmonary and Critical Care Medicine and Infectious Disease, Department of Medicine, University of Tennessee, Memphis, Tennessee, USA
    Crit Care 6:24-9. 2002
    ..The bidirectional effects of proinflammatory cytokines on bacterial growth may help to explain the frequent occurrence of nosocomial infections in patients with unresolving acute respiratory distress syndrome...
  20. pmc Clinical risk conditions for acute lung injury in the intensive care unit and hospital ward: a prospective observational study
    Niall D Ferguson
    Interdepartmental Division of Critical Care Medicine, University Health Network, University of Toronto, 399 Bathurst Street, F2 150, Toronto, Ontario M5T 2S8, Canada
    Crit Care 11:R96. 2007
    ....
  21. ncbi Transfusion-related acute lung injury: epidemiology and a prospective analysis of etiologic factors
    Christopher C Silliman
    Bonfils Blood Center and the Department of Pediatrics, University of Colorado School of Medicine, Denver, USA
    Blood 101:454-62. 2003
    ..TRALI, like the acute respiratory distress syndrome, may be a 2-event phenomenon with both recipient predisposition and factors in the stored units playing major roles...
  22. pmc Neutrophils and their Fc gamma receptors are essential in a mouse model of transfusion-related acute lung injury
    Mark R Looney
    Cardiovascular Research Institute, Department of Medicine, UCSF, San Francisco, California, USA
    J Clin Invest 116:1615-23. 2006
    ..In conclusion, in a clinically relevant in vivo mouse model of TRALI using an MHC I mAb, the mechanism of lung injury was dependent on neutrophils and their Fc gamma receptors...
  23. ncbi Within-breath arterial PO2 oscillations in an experimental model of acute respiratory distress syndrome
    E M Williams
    Nuffield Department of Anaesthetics, University of Oxford, Radcliffe Infirmary, UK
    Br J Anaesth 85:456-9. 2000
    ....
  24. pmc Loss of extracellular superoxide dismutase leads to acute lung damage in the presence of ambient air: a potential mechanism underlying adult respiratory distress syndrome
    Maria Carolina Gongora
    Department of Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
    Am J Pathol 173:915-26. 2008
    ..arterial-alveolar gradient, respiratory acidosis, histological changes similar to those observed in adult respiratory distress syndrome, and 85% mortality...
  25. ncbi Significance of von Willebrand factor in septic and nonseptic patients with acute lung injury
    Lorraine B Ware
    Division of Allergy, Pulmonary and Critical Care Medicine, T1217 MCN, Vanderbilt University School of Medicine, Nashville, TN 37232 2650, USA
    Am J Respir Crit Care Med 170:766-72. 2004
    ..To improve outcomes further, new treatment strategies targeted at the endothelium should be investigated...
  26. ncbi One-year outcomes in survivors of the acute respiratory distress syndrome
    Margaret S Herridge
    Department of Medicine, University Health Network, Toronto, Ont, Canada
    N Engl J Med 348:683-93. 2003
    ..As more patients survive the acute respiratory distress syndrome, an understanding of the long-term outcomes of this condition is needed...
  27. ncbi Vascular endothelial growth factor and related molecules in acute lung injury
    Marco Mura
    Thoracic Surgery Research Laboratories, Toronto Generl Research Institute, University Health Network, Toronto, Ontario, Canada M5G 2C4
    J Appl Physiol (1985) 97:1605-17. 2004
    ..Understanding the role of VEGF in this disease process is crucial for developing new therapeutic strategies for ALI/ARDS...
  28. ncbi Pathophysiology of acute lung injury and the acute respiratory distress syndrome
    Lorraine B Ware
    Division of Allergy, Pulmonary, and Critical Care Medicine, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    Semin Respir Crit Care Med 27:337-49. 2006
    Since the adult respiratory distress syndrome was first described substantial progress has been made in understanding the pathogenesis of this complex syndrome...
  29. ncbi Pulmonary endothelium in acute lung injury: from basic science to the critically ill
    S E Orfanos
    Department of Critical Care and Pulmonary Medicine, M Simou Laboratory, Medical School, University of Athens, Evangelismos Hospital, 45 47 Ipsilandou St, 10675, Athens, Greece
    Intensive Care Med 30:1702-14. 2004
    ..Noxious agents that affect pulmonary endothelium induce alterations in hemodynamics and hemofluidity, promote interactions with circulating blood cells, and lead to increased vascular permeability and pulmonary edema formation...
  30. ncbi Incidence of acute lung injury in the United States
    Christopher H Goss
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Washington Medical Center, Seattle, WA, USA
    Crit Care Med 31:1607-11. 2003
    ..We hypothesized that careful, prospective, protocol-driven case identification that included the milder hypoxemia criterion for ALI would yield incidence numbers greater than previously reported...
  31. ncbi Comparison of clinical criteria for the acute respiratory distress syndrome with autopsy findings
    Andres Esteban
    Hospital Universitario de Getafe, Madrid, Spain
    Ann Intern Med 141:440-5. 2004
    ..The American-European Consensus Conference definition for the acute respiratory distress syndrome (ARDS) has never been validated...
  32. ncbi Acute respiratory distress syndrome: underrecognition by clinicians and diagnostic accuracy of three clinical definitions
    Niall D Ferguson
    Interdepartmental Division of Critical Care Medicine and the Department of Medicine, Division of Respirology, University Health Network and Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada
    Crit Care Med 33:2228-34. 2005
    ..A second objective was to determine the accuracy of clinical diagnoses of ARDS made in daily practice...
  33. ncbi The alveolar space is the site of intense inflammatory and profibrotic reactions in the early phase of acute respiratory distress syndrome
    J Pugin
    Department of Internal Medicine, University Hospital of Geneva, Switzerland
    Crit Care Med 27:304-12. 1999
    ....
  34. ncbi Clinically relevant concentrations of beta2-adrenergic agonists stimulate maximal cyclic adenosine monophosphate-dependent airspace fluid clearance and decrease pulmonary edema in experimental acid-induced lung injury
    Daniel F McAuley
    Cardiovascular Research Institute, University of California, San Francisco, CA, USA
    Crit Care Med 32:1470-6. 2004
    ....
  35. pmc Adenoviral transfer of HSP-70 into pulmonary epithelium ameliorates experimental acute respiratory distress syndrome
    Yoram G Weiss
    Department of Anesthesia, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    J Clin Invest 110:801-6. 2002
    ..CLP-associated mortality at 48 hours was reduced by half. Modulation of HSP-70 production reduces pathologic changes and may improve outcome in experimental ARDS...
  36. pmc Clinical review: Positive end-expiratory pressure and cardiac output
    Thomas Luecke
    Department of Anesthesiology and Critical Care Medicine, University Hospital of Mannheim, Germany
    Crit Care 9:607-21. 2005
    ..Finally, the hemodynamic consequences of PEEP in patients with heart failure, chronic obstructive pulmonary disease and acute respiratory distress syndrome are discussed...
  37. ncbi Positive end-expiratory pressure after a recruitment maneuver prevents both alveolar collapse and recruitment/derecruitment
    Jeffrey M Halter
    Department of Surgery, State University of New York Upstate Medical University, 750 E Adams Street, Syracuse, NY 13210, USA
    Am J Respir Crit Care Med 167:1620-6. 2003
    ..This suggests recruitment followed by inadequate PEEP permits unstable alveoli and may result in ventilator-induced lung injury despite improved oxygenation...
  38. ncbi Acute respiratory failure in intensive care units. FINNALI: a prospective cohort study
    Rita Linko
    Intensive Care Units, Department of Anaesthesia and Intensive Care Medicine, Division of Surgery, Helsinki University Hospital, Helsinki, Finland
    Intensive Care Med 35:1352-61. 2009
    ..To evaluate the incidence, treatment and mortality of acute respiratory failure (ARF) in Finnish intensive care units (ICUs)...
  39. pmc Positive end-expiratory pressure at minimal respiratory elastance represents the best compromise between mechanical stress and lung aeration in oleic acid induced lung injury
    Alysson Roncally S Carvalho
    Biomedical Engineering Program, COPPE, Federal University of Rio de Janeiro, Av, Horácio Macedo, CT Bloco H 327, 2030, 21941 914, Rio de Janeiro, Brazil
    Crit Care 11:R86. 2007
    ....
  40. ncbi Comparison of two fluid-management strategies in acute lung injury
    Herbert P Wiedemann
    Department of Pulmonary, Allergy, and Critical Care Medicine, Cleveland Clinic, 9500 Euclid Ave, Desk A 90, Cleveland, OH 44195, USA
    N Engl J Med 354:2564-75. 2006
    ..Optimal fluid management in patients with acute lung injury is unknown. Diuresis or fluid restriction may improve lung function but could jeopardize extrapulmonary-organ perfusion...
  41. ncbi Neutrophil elastase inhibition in acute lung injury: results of the STRIVE study
    Bernhardt G Zeiher
    Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN 46285, USA
    Crit Care Med 32:1695-702. 2004
    ....
  42. ncbi Alveolar epithelial fluid transport in acute lung injury: new insights
    C Sartori
    Cardiovascular Research Institute, University of California San Francisco, San Francisco, CA 94143 0130, USA
    Eur Respir J 20:1299-313. 2002
    ..Very recent data suggest that mechanisms that augment transepithelial sodium transport and enhance the clearance of alveolar oedema may lead to more effective prevention or treatment for some types of pulmonary oedema...
  43. ncbi Hyperoxia in the intensive care unit: why more is not always better
    William A Altemeier
    Department of Medicine, University of Washington, Seattle, Washington 98195 6522, USA
    Curr Opin Crit Care 13:73-8. 2007
    ..This review identifies relevant new findings regarding hyperoxic lung injury in the context of providing guidance for future clinical studies...
  44. ncbi Recruitment and derecruitment during acute respiratory failure: a clinical study
    S Crotti
    Istituto di Anestesia e Rianimazione, , Ospedale Maggiore Policlinico-IRCCS, Milan, Italy
    Am J Respir Crit Care Med 164:131-40. 2001
    ..When superimposed gravitational pressure exceeded PEEP, end-expiratory collapse increased. We concluded that the rules governing recruitment and derecruitment equally apply in an oleic acid model and in human ALI/ARDS...
  45. ncbi Intestinal ischemia-reperfusion-induced acute lung injury and oncotic cell death in multiple organs
    Marco Mura
    Thoracic Surgery Research Laboratories, Toronto General Hospital, University Health Network, Department of Surgery, Faculty of Medicine, University of Toronto, Toronto, Canada
    Shock 28:227-38. 2007
    ..These results indicate that, although lung injury is the most significant manifestation after IIR, oncotic cell death occurs in the lung, heart, and kidney, which may be related to ischemia and inflammation...
  46. ncbi A randomized, controlled trial of furosemide with or without albumin in hypoproteinemic patients with acute lung injury
    Greg S Martin
    Division of Pulmonary, Allergy and Critical Care, Department of Medicine, Emory University School of Medicine, Atlanta, GA, USA
    Crit Care Med 33:1681-7. 2005
    ..Albumin with furosemide benefits lung physiology in hypoproteinemic patients with acute lung injury/acute respiratory distress syndrome, but the independent pharmacologic effects of these drugs are unknown...
  47. ncbi Extracorporeal Membrane Oxygenation for 2009 Influenza A(H1N1) Acute Respiratory Distress Syndrome
    Andrew Davies
    FRACP, FJFICM, Intensive Care Unit, Alfred Hospital, Commercial Road, Melbourne, Victoria 3004, Australia
    JAMA 302:1888-95. 2009
    ..It caused an epidemic of critical illness and some patients developed severe acute respiratory distress syndrome (ARDS) and were treated with extracorporeal membrane oxygenation (ECMO)...
  48. ncbi Pharmacology of acute lung injury
    Sadatomo Tasaka
    Department of Medicine, Keio University School of Medicine, Tokyo, Japan
    Pulm Pharmacol Ther 15:83-95. 2002
    ..Replacements of anticoagulation mediators have also suggested beneficial effects on the patient outcome. This article provides an overview of pharmacological treatments of ALI/ARDS...
  49. ncbi Electrical impedance tomography: a method for monitoring regional lung aeration and tidal volume distribution?
    Inez Frerichs
    Department of Anaesthesiological Research, Centre of Anaesthesiology, Emergency and Intensive Care Medicine, University of Gottingen, Robert Koch Strasse 40, 37075, Gottingen, Germany
    Intensive Care Med 29:2312-6. 2003
    ..To demonstrate the monitoring capacity of modern electrical impedance tomography (EIT) as an indicator of regional lung aeration and tidal volume distribution...
  50. ncbi Effects of respiratory rate, plateau pressure, and positive end-expiratory pressure on PaO2 oscillations after saline lavage
    James E Baumgardner
    Department of Anesthesia, School of Veterinary Medicine, and Center for Sleep and Respiratory Neurobiology, University of Pennsylvania, Philadelphia 19104 4283, USA
    Am J Respir Crit Care Med 166:1556-62. 2002
    ..The important effect of RR on the magnitude of PaO2 oscillations suggests that the static behavior of atelectasis cannot be accurately extrapolated to predict dynamic behavior at realistic breathing frequencies...
  51. pmc Bench-to-bedside review: Biotrauma and modulation of the innate immune response
    Claudia C dos Santos
    Department of Medicine, St Michael s Hospital, University of Toronto, Toronto, Ontario, Canada
    Crit Care 9:280-6. 2005
    ..In this paper, we explore the pertinent evidence implicating biotrauma caused by cyclic MV and its effect on innate immune responses...
  52. ncbi Effect of mechanical ventilation on inflammatory mediators in patients with acute respiratory distress syndrome: a randomized controlled trial
    V M Ranieri
    Istituto di Anestesiologia e Rianimazione, Universita di Bari, Ospedale Policlinico, Italy
    JAMA 282:54-61. 1999
    ....
  53. ncbi Relationship between neutrophil elastase and acute lung injury in humans
    Shouetsu Tamakuma
    National Defense Medical College, 3 2 Namiki, Tokorozawa, Saitama 359 0042, Japan
    Pulm Pharmacol Ther 17:271-9. 2004
    ..It was concluded that neutrophil elastase may be involved in the pathogenesis of ALI in humans...
  54. ncbi Mechanical ventilation in acute respiratory failure: recruitment and high positive end-expiratory pressure are necessary
    Carmen Silvia Valente Barbas
    Division of Pulmonary and Critical Care, University of Sao Paulo, Sao Paulo, Brazil and Intensive Care Unit, Albert Einstein Hospital, Sao Paulo, Brazil
    Curr Opin Crit Care 11:18-28. 2005
    ....
  55. ncbi Acute lung injury and bacterial infection
    Didier Dreyfuss
    Service de Reanimation Medicale, Hopital Louis Mourier, Assistance Publique Hopitaux de Paris, Colombes 92700, France
    Clin Chest Med 26:105-12. 2005
    ..This complication is responsible for more than a doubling of the time on mechanical ventilation but does not seem to increase mortality...
  56. ncbi Influence of respiratory rate on gas trapping during low volume ventilation of patients with acute lung injury
    Jean Christophe Richard
    Medical Intensive Care Unit, University Hospital Charles Nicolle, 1 rue de Germont, 76031 Rouen, France
    Intensive Care Med 28:1078-83. 2002
    ..The aim of this study was to test whether a high respiratory rate induces significant intrinsic positive end-expiratory pressure (PEEPi) in these patients...
  57. ncbi High-frequency oscillatory ventilation: mechanisms of gas exchange and lung mechanics
    J Jane Pillow
    Institute for Child Health Research, and the School of Women s and Infants Health, University of Western Australia, Subiaco, Perth, Australia
    Crit Care Med 33:S135-41. 2005
    ....
  58. pmc Vascular endothelial growth factor gene polymorphism and acute respiratory distress syndrome
    A R L Medford
    Lung Research Group, Department of Clinical Science at North Bristol, University of Bristol, Southmead Hospital, Westbury on Trym, Bristol BS10 5NB, UK
    Thorax 60:244-8. 2005
    ..Lower VEGF plasma levels have been linked to the presence of the T allele in the +936 CT polymorphism. We hypothesised that the presence of the T allele would be associated with the development and severity of ARDS...
  59. ncbi -308GA and TNFB polymorphisms in acute respiratory distress syndrome
    M N Gong
    Harvard School of Public Health, 665 Huntington Avenue, Boston, MA 02115, USA
    Eur Respir J 26:382-9. 2005
    ....
  60. ncbi Increased circulating endothelial progenitor cells are associated with survival in acute lung injury
    Ellen L Burnham
    Division of Pulmonary, Allergy, and Critical Care, Department of Medicine, Emory University School of Medicine, and the Atlanta Venterans Affairs Medical Center, Atlanta, GA 30335, USA
    Am J Respir Crit Care Med 172:854-60. 2005
    ..Repair of damaged endothelium is important in recovery from acute lung injury. In animal models, bone marrow-derived endothelial progenitor cells differentiate into mature endothelium and assist in repairing damaged vasculature...
  61. ncbi The role of open-lung biopsy in ARDS
    Sanjay R Patel
    Pulmonary and Critical Care Unit, Massachusetts General Hospital, Boston, MA 02115, USA
    Chest 125:197-202. 2004
    ..The goals of this study were to better define the frequency of unexpected diagnoses made by open-lung biopsy, the frequency biopsy results lead to a change in clinical management, and the frequency of procedural complications...
  62. ncbi Management of acute lung injury and acute respiratory distress syndrome in children
    Adrienne G Randolph
    Division of Critical Care Medicine, Department of Anesthesia, Perioperative and Pain Medicine, Children s Hospital, Boston, MA, USA
    Crit Care Med 37:2448-54. 2009
    ..Acute lung injury (ALI) and its more severe form, acute respiratory distress syndrome (ARDS), are devastating disorders of overwhelming pulmonary inflammation and hypoxemia, resulting in high morbidity and mortality...
  63. ncbi Heterogeneous expression of cell adhesion molecules by endothelial cells in ARDS
    Annette M Müller
    Institute of Pathology, University Clinic Bergmannsheil, Ruhr University Bochum, Burkle de la Camp Platz 1, 44789 Bochum, Germany
    J Pathol 198:270-5. 2002
    ..There is also markedly heterogeneous expression of E-selectin and VCAM, indicating toporegional differences in the function of pulmonary ECs...
  64. pmc Adult respiratory distress syndrome as a severe immune reconstitution disease following the commencement of highly active antiretroviral therapy
    N R Goldsack
    Department of Respiratory and HIV Medicine, Royal Free Hospital, Hampstead, London, UK
    Sex Transm Infect 79:337-8. 2003
    We report a patient who developed adult respiratory distress syndrome (ARDS) secondary to Mycobacterium tuberculosis as an immune reconstitution disease...
  65. ncbi Methylprednisolone infusion in early severe ARDS: results of a randomized controlled trial
    G Umberto Meduri
    Division of Pulmonary, Critical Care, and Sleep Medicine, University of Tennessee Health Science Center, 956 Court Ave, Room H316, Memphis, TN 38163, USA
    Chest 131:954-63. 2007
    ..To determine the effects of low-dose prolonged methylprednisolone infusion on lung function in patients with early severe ARDS...
  66. ncbi Adult respiratory distress syndrome: a complication of induced hypertension after severe head injury
    C F Contant
    Department of Neurosurgery, Baylor College of Medicine, Houston, Texas 77030, USA
    J Neurosurg 95:560-8. 2001
    OBJECT: The factors involved in the development of adult respiratory distress syndrome (ARDS) after severe head injury were studied...
  67. ncbi Epidemiology of acute lung injury and acute respiratory distress syndrome
    Fernando Frutos-Vivar
    Intensive Care Unit, Hospital Universitario de Getafe, Madrid, Spain
    Curr Opin Crit Care 10:1-6. 2004
    ..Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are diseases with a significant influence in the public health. A better knowledge of their epidemiology could help to improve the outcome of these diseases...
  68. ncbi Quantification of lung water by transpulmonary thermodilution in normal and edematous lung
    Enrique Fernandez-Mondejar
    Hospital Universitario Virgen de las Nieves, Granada, Spain
    J Crit Care 18:253-8. 2003
    ..To analyze the accuracy of the transpulmonary thermodilution method in the determination of extravascular lung water (EVLW)...
  69. pmc Pharmacotherapy of acute lung injury and acute respiratory distress syndrome
    Krishnan Raghavendran
    Department of Surgery, State University of New York SUNY at Buffalo, Buffalo, NY 14214, USA
    Curr Med Chem 15:1911-24. 2008
    ..However, many of these agents have complementary biological/biochemical activities with the potential for synergy or additivity in combination therapy as discussed in this article...
  70. ncbi Kinetic and reversibility of mechanical ventilation-associated pulmonary and systemic inflammatory response in patients with acute lung injury
    F Stuber
    Department of Anesthesiology and Intensive Care Medicine, University of Bonn, Sigmund Freud Str 25, 53105 Bonn, Germany
    Intensive Care Med 28:834-41. 2002
    ..To investigate the kinetic and reversibility of mechanical ventilation-associated pulmonary and systemic inflammatory response in patients with acute lung injury (ALI)...
  71. pmc Development of animal models for the acute respiratory distress syndrome
    Julie A Bastarache
    Department of Medicine, Division of Allergy, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Dis Model Mech 2:218-23. 2009
    ..Hopefully, as new technologies and approaches emerge, barriers to scientific progress in ARDS will be overcome...
  72. ncbi Elevated plasma surfactant protein-B predicts development of acute respiratory distress syndrome in patients with acute respiratory failure
    A D Bersten
    Department of Critical Care Medicine, Flinders Medical Centre and School of Medicine, Flinders University, South Australia
    Am J Respir Crit Care Med 164:648-52. 2001
    ..87 [0.72 to 1.02]), with a sensitivity of 85% (95% CI: 55 to 98%) and specificity of 78% (40 to 97%) at a cutoff of 4,994 ng/ml...
  73. ncbi Higher versus lower positive end-expiratory pressures in patients with the acute respiratory distress syndrome
    Roy G Brower
    Johns Hopkins University, Baltimore, USA
    N Engl J Med 351:327-36. 2004
    ..We conducted this trial to compare the effects of higher and lower PEEP levels on clinical outcomes in these patients...
  74. ncbi Transcriptional mechanisms of acute lung injury
    J Fan
    Department of Pharmacology, College of Medicine, University of Illinois at Chicago, Chicago, Illinois 60612, USA
    Am J Physiol Lung Cell Mol Physiol 281:L1037-50. 2001
    ..NF-kappa B can interact with other transcription factors, and these interactions thereby lead to greater transcriptional selectivity. Modification of transcription is likely to be a logical therapeutic target for acute lung injury...
  75. ncbi Incidence, clinical course, and outcome in 217 patients with acute respiratory distress syndrome
    Elisa Estenssoro
    Hospital de Agudos General San Martin de La Plata de Capital Federal, República, Argentina
    Crit Care Med 30:2450-6. 2002
    ..To assess prospectively acute respiratory distress syndrome incidence, etiologies, physiologic and clinical features, and mortality and its predictors in four intensive care units in Argentina...
  76. pmc Epithelial cell apoptosis and neutrophil recruitment in acute lung injury-a unifying hypothesis? What we have learned from small interfering RNAs
    Mario Perl
    Department of Traumatology, Hand and Reconstructive Surgery, University of Ulm Medical School, Ulm, Germany
    Mol Med 14:465-75. 2008
    ....
  77. ncbi Pneumonia in acute respiratory distress syndrome. A prospective evaluation of bilateral bronchoscopic sampling
    G U Meduri
    Pulmonary and Critical Care Division, University of Tennessee and Veterans Administration Medical Center, Memphis, Tennessee, USA
    Am J Respir Crit Care Med 158:870-5. 1998
    ..In patients with ARDS and suspected VAP, bilateral BAL quantitative bacterial cultures had significant growth on one side only in 19% and in both sides in 13%...
  78. ncbi Chronic alcohol abuse, acute respiratory distress syndrome, and multiple organ dysfunction
    Marc Moss
    Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, Emory University School of Medicine, Atlanta, GA, USA
    Crit Care Med 31:S207-12. 2003
    ..To review the effects of chronic alcohol abuse on the incidence, severity, and pathogenesis of acute respiratory distress syndrome (ARDS) and multiple organ dysfunction...
  79. ncbi Alveolar epithelial barrier. Role in lung fluid balance in clinical lung injury
    M A Matthay
    Cardiovascular Research Institute, University of California San Francisco, San Francisco, USA
    Clin Chest Med 21:477-90. 2000
    ..e., beta-agonists) and more sustained, longer-term effects of epithelial mitogens such as keratinocyte growth factor. These approaches may be useful in reducing mortality in the acute respiratory distress syndrome...
  80. ncbi Toward an understanding of transfusion-related acute lung injury: statement of a consensus panel
    Steven Kleinman
    Kleinman Biomedical Research, Victoria, British Columbia, Canada
    Transfusion 44:1774-89. 2004
  81. pmc The pulmonary physician in critical care * 6: The pathogenesis of ALI/ARDS
    G J Bellingan
    Thorax 57:540-6. 2002
    ..The key mediators involved in the inflammatory and fibroproliferative responses are reviewed and the mechanisms which regulate these responses are highlighted...
  82. ncbi Plasma levels of the three endothelial-specific proteins von Willebrand factor, tissue factor pathway inhibitor, and thrombomodulin do not predict the development of acute respiratory distress syndrome
    M S Bajaj
    Department of Internal Medicine, Saint Louis University School of Medicine, Missouri, USA
    Intensive Care Med 25:1259-66. 1999
    ....
  83. ncbi Prone positioning, systemic hemodynamics, hepatic indocyanine green kinetics, and gastric intramucosal energy balance in patients with acute lung injury
    Rudolf Hering
    Department of Anesthesiology and Intensive Care Medicine, University of Bonn, Sigmund Freud Strasse 25, 53105 Bonn, Germany
    Intensive Care Med 28:53-8. 2002
    ..To investigate the effects of prone positioning on systemic hemodynamics, intra-abdominal pressure (IAP), plasma disappearance rate of indocyanine green (PDR(ICG)), and gastric intramucosal to arterial PCO2 difference (Pi-aCO2)...
  84. ncbi The role of neutrophil elastase in acute lung injury
    Kazuhito Kawabata
    Minase Research Institute, Ono Pharmaceutical Co, Ltd, 3 1 1 Sakurai, Shimamoto, Mishima, Osaka 618 8585, Japan
    Eur J Pharmacol 451:1-10. 2002
    ..A greater understanding of the role of this enzyme in the pathophysiology of acute lung injury will lead to better treatments for this complicated disease...
  85. ncbi Hepatic cryoablation-induced acute lung injury: pulmonary hemodynamic and permeability effects in a sheep model
    W C Chapman
    Division of Hepatobiliary Surgery, Vanderbilt University Medical Center, Nashville, Tenn 37232 4753, USA
    Arch Surg 135:667-72; discussion 672-3. 2000
    ..Hepatic cryoablation of 30% to 35% or more of liver parenchyma in a sheep model results in eicosanoid and nuclear factor-kappaB (NF-kappaB)-mediated changes in pulmonary hemodynamics and lung permeability...
  86. ncbi Effect of prolonged methylprednisolone therapy in unresolving acute respiratory distress syndrome: a randomized controlled trial
    G U Meduri
    Baptist Memorial Hospitals, Veterans Affairs Medical Center, University of Tennessee, Memphis, USA
    JAMA 280:159-65. 1998
    ..No pharmacological therapeutic protocol has been found effective in modifying the clinical course of acute respiratory distress syndrome (ARDS) and mortality remains greater than 50%...
  87. ncbi Respiratory controversies in the critical care setting. Should recruitment maneuvers be used in the management of ALI and ARDS?
    Robert M Kacmarek
    Respiratory Care Services, Massachusetts General Hospital, and Harvard Medical School, Boston, MA 02114, USA
    Respir Care 52:622-31; discussion 631-5. 2007
    ..We explore both sides of the lung recruitment controversy...
  88. ncbi Keratinocyte and hepatocyte growth factors in the lung: roles in lung development, inflammation, and repair
    Lorraine B Ware
    Division of Pulmonary and Critical Care, Department of Medicine, University of California, Los Angeles 90024, USA
    Am J Physiol Lung Cell Mol Physiol 282:L924-40. 2002
    ....
  89. pmc A 9-year, single-institution, retrospective review of death rate and prognostic factors in adult respiratory distress syndrome
    T R Rocco Jr
    Department of Surgery, Division of Surgical Critical Care, Brown University School of Medicine and Rhode Island Hospital, Providence, Rhode Island, USA
    Ann Surg 233:414-22. 2001
    OBJECTIVE: To evaluate, at a single institution, the adult respiratory distress syndrome (ARDS) death rate in critically ill ventilated surgical/trauma patients and to identify the factors predicting death in these patients...
  90. ncbi Bronchoalveolar coagulation and fibrinolysis in endotoxemia and pneumonia
    Marcel Levi
    Department of Vascular Medicine ML, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Crit Care Med 31:S238-42. 2003
    ..To review the involvement of coagulation and fibrinolysis in the pathogenesis of acute lung injury during severe infection. To review the cross-talk between coagulation and inflammation that may affect this response...
  91. ncbi Pulmonary pathology of acute respiratory distress syndrome
    J F Tomashefski
    Department of Pathology, MetroHealth Medical Center, Cleveland, Ohio, USA
    Clin Chest Med 21:435-66. 2000
    ....
  92. ncbi The beta-agonist lung injury trial (BALTI): a randomized placebo-controlled clinical trial
    Gavin D Perkins
    Department of Intensive Care Medicine, Birmingham Heartlands Hospital, UK
    Am J Respir Crit Care Med 173:281-7. 2006
    ..Experimental data suggest that manipulation of alveolar fluid clearance with beta-agonists can accelerate the resolution of alveolar edema and improve survival...
  93. ncbi Low hospital mortality in patients with acute interstitial pneumonia
    Amir Quefatieh
    Division of Pulmonary, Critical Care, Allergy, Immunology and Sleep Medicine, Henry Ford Health Sciences Center, Detroit, USA
    Chest 124:554-9. 2003
    ..To compare the presenting features and outcome of patients with acute interstitial pneumonia (AIP) with other patients with diffuse alveolar damage (DAD) and with historical control subjects...
  94. pmc Pathogenetic and prognostic significance of altered coagulation and fibrinolysis in acute lung injury/acute respiratory distress syndrome
    Lorraine B Ware
    Division of Allergy, Pulmonary, and Critical Care Medicine, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN, USA
    Crit Care Med 35:1821-8. 2007
    ..However, direct evidence for the contribution of abnormalities in coagulation and fibrinolysis proteins to outcomes in patients with acute lung injury/acute respiratory distress syndrome is lacking...
  95. ncbi Visual validation of the mechanical stabilizing effects of positive end-expiratory pressure at the alveolar level
    U G McCann
    Department of Surgery, State University of New York Upstate Medical University, 750 East Adams Street, Syracuse, NY 13210. USA
    J Surg Res 99:335-42. 2001
    ..The ability of PEEP to stabilize alveoli and reduce shear during mechanical ventilation has important implications for therapeutic strategies directed at VILI and acute respiratory distress syndrome...
  96. ncbi Has mortality from acute respiratory distress syndrome decreased over time?: A systematic review
    Jason Phua
    F R C P C, Toronto Western Hospital, 399 Bathurst Street, 2MCL 411M, Toronto, ON M5T 2S8, Canada
    Am J Respir Crit Care Med 179:220-7. 2009
    ..It is commonly stated that mortality from acute respiratory distress syndrome (ARDS) and acute lung injury (ALI) is decreasing...
  97. ncbi Causes and timing of death in patients with ARDS
    Renee D Stapleton
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, Harborview Medical Center, University of Washington School of Medicine, Box 359762, 325 Ninth Ave, Seattle, WA 98104, USA
    Chest 128:525-32. 2005
    ..Since the early 1980s, case fatality of patients with ARDS has decreased, and explanations are unclear...
  98. pmc Mechanical ventilation guided by esophageal pressure in acute lung injury
    Daniel Talmor
    Department of Anesthesia, Critical Care, and Pain Medicine, Beth Israel Deaconess Medical Center, Boston 02215, USA
    N Engl J Med 359:2095-104. 2008
    ....
  99. ncbi Evolution of mechanical ventilation in response to clinical research
    Andres Esteban
    Intensive Care Unit, Hospital Universitario de Getafe, Carretera de Toledo Km 12, 500, 28905 Getafe, Madrid, Spain
    Am J Respir Crit Care Med 177:170-7. 2008
    ..Recent literature in mechanical ventilation includes strong evidence from randomized trials. Little information is available regarding the influence of these trials on usual clinical practice...
  100. ncbi Increased concentrations of leukotrienes in bronchoalveolar lavage fluid of patients with ARDS or at risk for ARDS
    A H Stephenson
    Department of Pharmacology, St Louis University School of Medicine, Missouri 63104
    Am Rev Respir Dis 138:714-9. 1988
    ..the evaluation of the hypothesis that these leukotrienes participate in the edema formation of the adult respiratory distress syndrome (ARDS), we investigated whether LTC4 and LTD4 were present in the bronchoalveolar lavage (BAL) ..
  101. ncbi High-frequency oscillatory ventilation following prone positioning prevents a further impairment in oxygenation
    Didier Demory
    Service de Reanimation Medicale, Hopital Sainte Marguerite, Universite de la Mediterranee, Marseille, France
    Crit Care Med 35:106-11. 2007
    ..The aim of this study was to show that HFOV is able to prevent the impairment in oxygenation when ARDS patients are turned back from the prone to the supine position...

Research Grants62

  1. Vascular endothelial growth factor induced lung edema
    Robert Kaner; Fiscal Year: 2004
    b>Adult respiratory distress syndrome (ARDS) affects 150,000 individuals in the US annually with a mortality of 40 percent. Current treatment is supportive only...
  2. Regulation and function of Cyr61 in hyperoxia induced acute lung injury
    Yang Jin; Fiscal Year: 2010
    b>Adult respiratory distress syndrome (ARDS) is a devastating syndrome responsible for significant morbidity and mortality in our intensive care units...
  3. Mechanisms of Prostacyclin-Mediated Lung Endothelial Barrier Protection
    Konstantin Birukov; Fiscal Year: 2013
    ..by applicant): Development of effective therapies for treatment of acute lung injury (ALI) and adult respiratory distress syndrome (ARDS) remains a challenging task...
  4. STAT3 and its Acetylation in Acute Lung Injury
    Hongwei Gao; Fiscal Year: 2012
    Acute lung injury (ALI) and its progression to adult respiratory distress syndrome (ARDS) remain leading factors of morbidity and mortality in critically ill patients...
  5. Phase II, randomized controlled trial of brain tissue oxygen monitoring
    Nancy R Temkin; Fiscal Year: 2011
    ..does not result in increased risk of pulmonary or systemic complications (such as acute lung injury/Adult Respiratory Distress Syndrome (ALI/ARDS). (3)...
  6. Biomimetic Design and Construction of an Artificial Lung
    Jeffrey T Borenstein; Fiscal Year: 2012
    ..For acute illnesses such as Adult Respiratory Distress Syndrome (ARDS), mechanical ventilation is typically required, and complications and mortality remain very ..
  7. Design of novel complement inhibitors
    John D Lambris; Fiscal Year: 2010
    ..has been reported in a wide variety of disorders, including but not limited to autoimmune diseases, adult respiratory distress syndrome, Alzheimer's disease, stroke, heart attack, burn injuries, age related macular degeneration, ..
  8. Substrate stiffness regulates alveolar epithelial cell behavior
    Jonathan C Jones; Fiscal Year: 2013
    In patients with acute lung injury (ALI) or the adult respiratory distress syndrome (ARDS), disordered repair of the injured alveolar epithelium can result in lung fibrosis...
  9. THROMBIN-INDUCED PULMONARY VASCULAR PERMEABILITY
    Asrar B Malik; Fiscal Year: 2012
    ..Increase in lung vascular permeability results in an array of pathological conditions including Adult Respiratory Distress Syndrome. The endothelial adherens junctions (AJs) consisting of VE-cadherin and its associated catenins is ..
  10. Lung Metabolism: Multiple Indicator Dilution
    Said H Audi; Fiscal Year: 2010
    ..in patients with lung failure secondary to chronic obstructive pulmonary diseases, pneumonia, or adult respiratory distress syndrome is elevated 02 therapy (hyperoxia). However, prolonged exposure to hyperoxia causes lung injury...
  11. Neurtophil Homeostasis and Lung Sequestration
    G Scott Worthen; Fiscal Year: 2010
    ..A number of neutrophil-dependent lung disorders, including the Adult Respiratory Distress Syndrome (ARDS) are characterized by release of immature neutrophils from marrow into the circulation...
  12. Role of End Binding 3 in Mechanism of vascular permeability
    Yulia A Komarova; Fiscal Year: 2013
    ..Increases in lung vascular permeability result in protein-rich tissue edema, an important feature of adult respiratory distress syndrome. The role of the microtubule (MT) cytoskeleton in the mechanism of increased endothelial ..
  13. SEQUENTIAL MODEL OF LEUKOCYTE ROLLING AND ARREST IN FLOW
    Michael Lawrence; Fiscal Year: 1999
    ..in damage to tissues, particularly following ischemia; and has also been shown to play a role in adult respiratory distress syndrome and septic shock associated multi.organ failure...
  14. PATHOPHYSIOLOGY OF ISCHEMIA-REPERFUSION LUNG INJURY
    AUBREY TAYLOR; Fiscal Year: 1992
    ..of major pulmonary arteries, and may be a factor in re-expansion pulmonary edema and in the adult respiratory distress syndrome in which smaller thrombosed pulmonary arteries become reperfused...
  15. REGULATION OF SUPEROXIDE PRODUCTION BY HUMAN NEUTROPHILS
    Jeffrey Friedman; Fiscal Year: 2007
    ..For example, in adult respiratory distress syndrome, pulmonary damage results from the excessive production of phagocyte oxidants, while in chronic ..
  16. ADVERSE EVENTS WITH MAGNESIUM SULFATE
    George Macones; Fiscal Year: 2000
    ..This complication may lead to maternal adult respiratory distress syndrome or death, and can have secondary adverse fetal consequences as well...
  17. BABESIOSIS AS A PARADIGM FOR THE EFFECTS OF AGING
    JEFFREY GELFAND; Fiscal Year: 2000
    ..splenectomized or immunocompromised individuals, with clinical symptoms ranging from high fevers to adult respiratory distress syndrome and shock. Severe symptoms are also observed in otherwise healthy individuals aged 50 and above...
  18. METALLOPROTEINASES IN VENTILATOR-INDUCED LUNG INJURY
    Hussein Foda; Fiscal Year: 2003
    ..Clinically, this condition is known as the Adult Respiratory Distress Syndrome (ARDS) that is characterized by catastrophic respiratory failure requiring mechanical ventilation (..
  19. HUMORAL CONTROL OF PULMONARY AND SYSTEMIC CIRCULATION
    PHILIP KADOWITZ; Fiscal Year: 1992
    ..lung in a number of pulmonary disorders including pulmonary embolism, gram negative sepsis, and the adult respiratory distress syndrome. Although TXA2 is released, little if anything is known about responses to this substance because ..
  20. DEVELOPMENT OF METHODS TO STUDY HANTAVIRUS REPLICATION
    Colleen Jonsson; Fiscal Year: 1999
    ..HFRS), while SNV is a newly-recognized species that is now implicated in the recent outbreak of adult respiratory distress syndrome. Unlike HFRS, the Hantavirus pulmonary syndrome (HPS), causes a lethal respiratory illness without ..
  21. EHRLICHIA CHAFFEENSIS SURFACE PROTEINS
    David Walker; Fiscal Year: 2000
    ..tick-borne infection that has been associated with toxic shock syndrome-like manifestations, adult respiratory distress syndrome, meningitis, and disseminated intravascular coagulation in immunocompetent patients, overwhelming ..
  22. TREATMENT OF ARDS WITH FRUCTOSE DIPHOSPHATE
    ANGEL MARKOV; Fiscal Year: 1991
    ..of the therapeutic effectiveness of Fructose-1,6-diphosphate Sodium Salt (FDP) in patients with Adult Respiratory Distress Syndrome (ARDS)...
  23. MECHANISMS OF NEUTROPHIL DYSFUNCTION IN BURNS AND TRAUMA
    Joseph Solomkin; Fiscal Year: 1993
    ..suffering extrapulmonary trauma or burn injury commonly suffer extensive lung injury, termed the adult respiratory distress syndrome (ARDS)...
  24. Matrix & Lysolipids Regulate Endothelial Cell Migration
    TRACEE PANETTI; Fiscal Year: 2006
    ..may protect the endothelium from damage and promote repair through endothelial cell migration in Adult Respiratory Distress Syndrome (ARDS)...
  25. MODULATION OF LUNG ENDOTHELIAL PERMEABILITY BY AUTACOIDS
    FREDERICK HASELTON; Fiscal Year: 1992
    ..of whole animal methods used to study the increased permeability edema often characteristic of the adult respiratory distress syndrome. Blood-tissue permeability increases are difficult to prove in animal models of increased ..
  26. LIPOXYGENASE PRODUCTS IN ACUTE RESPIRATORY FAILURE
    Neil Olson; Fiscal Year: 1992
    The adult respiratory distress syndrome (ARDS) is a form of acute respiratory failure (ARF) often associated with gram-negative sepsis and a mortality rate of 50% or higher...
  27. MECHANISM OF PAF INDUCED LUNG INJURY
    Hoyte van der Zee; Fiscal Year: 1990
    ..the platelet activating factor (PAF) as a mediator of lung injury and as a causative factor in the adult respiratory distress syndrome (ARDS)...
  28. Novel Antioxidant Mechanisms of Surfactant Proteins
    Francis McCormack; Fiscal Year: 2006
    ..properties of the surfactant membrane and contributes to respiratory failure in diseases such as adult respiratory distress syndrome. We have recently reported that the structurally related surfactant proteins A (SP-A) and D (SP-D) ..
  29. REGULATION OF MACROPHAGE INTERLEUKIN-1 BETA PRODUCTION
    MARK WEWERS; Fiscal Year: 2006
    ..infection and death whereas overexpression of these molecules can lead to tissue injury and the adult respiratory distress syndrome. Thus a better understanding of IL-1 beta physiology is critical to understanding lung host defense ..
  30. REGULATION AND FUNCTION OF HEME OXYGENASE-1
    SHARON CAMHI; Fiscal Year: 1999
    b>Adult respiratory distress syndrome (ARDS), a disease process often caused by gram negative sepsis, is responsible for much morbidity and mortality in critically ill patients...
  31. Integrin Regulation on Chromatin in Lung Endothelium
    Dale Hoyt; Fiscal Year: 2004
    ..bleomycin (BLM), which causes pulmonary fibrosis, and bacterial endotoxin (LPS), a factor in Adult Respiratory Distress Syndrome. Both agents cause acute, reversible DNA breakage and pulmonary inflammation...
  32. REGULATION OF NEUTROPHIL CHEMOTAXIS IN INFLAMMATION
    RICHARD PAINTER; Fiscal Year: 1993
    ..in the lung, it plays a causal role in mediating tissue damage associated with disease such as adult respiratory distress syndrome (ARDS), emphysema and pulmonary fibrosis...
  33. LUNG LAVAGE PROCOAGULANTS IN LUNG INJURY AND REPAIR
    Steven Idell; Fiscal Year: 1990
    ..fibrin deposition and the early development of pulmonary fibrosis are commonly found in the Adult Respiratory Distress Syndrome (ARDS). ARDS affects 150,000 patients annually and is lethal in half these cases...
  34. STAPHYLOCOCCAL TOXINS AND IL8 AND ARDS
    Edmund Miller; Fiscal Year: 2001
    The Adult Respiratory Distress Syndrome (ARDS) which affects approximately 150,000 individuals in the United States annually, is characterized by an acute deterioration of lung function in individuals who are already clinically ill...
  35. Integrated Maglev Pump-Oxygenator for Respiratory Support
    Kurt Dasse; Fiscal Year: 2009
    ..b>Adult respiratory distress syndrome (ARDS) alone afflicts approximately 150,000 patients every year with a mortality rate between 30-70%..
  36. LPS SIGNAL TRANSDUCTION IN NEUTROPHILS
    JERRY NICK; Fiscal Year: 2001
    ..of neutrophils by lipopoly-saccharide (LPS) is central to the pathogenesis of sepsis and the Adult Respiratory Distress Syndrome. LPS binds to CD14, a cell surface protein, resulting in actin assembly and adhesion...
  37. NO/CGMP SIGNAL TRANSDUCTION IN ACUTE PULMONARY INJURY
    KENNETH BLOCH; Fiscal Year: 1999
    ..pulmonary vasodilator which ameliorates the hypoxemia and pulmonary hypertension associated with adult respiratory distress syndrome (ARDS)...
  38. Anti-Inflammatory PAF Acetylhydrolase in Lung Injury
    Katherine Howard; Fiscal Year: 2004
    ..investigation of PAF acetylhydrolase in a wide range of inflammatory diseases including asthma, Adult Respiratory Distress Syndrome, diabetes, pancreatitis, and vascular and heart disease...
  39. MOLECULAR PROPERTIES OF NA+ CHANNELS IN LUNG ATII CELLS
    Dale Benos; Fiscal Year: 1999
    ..channels, and their involvement in pathophysiological processes, such as hyperoxic lung injury and Adult Respiratory Distress Syndrome (ARDS), are not known...
  40. LIPID-MEDIATED GENE TRANSFER TO PULMONARY ENDOTHELIUM
    Song Li; Fiscal Year: 2004
    ..gene transfer to the pulmonary circulation may be useful in treating pulmonary hypertension, adult respiratory distress syndrome or metastatic disease to the lung...
  41. STRETCH INDUCED ACTIVATION OF MAP KINASES IN THE LUNG
    Deborah Quinn; Fiscal Year: 2003
    The treatment of adult respiratory distress syndrome (ARDS) requires the use of positive pressure mechanical ventilation with high levels of inspired oxygen to provide adequate oxygenation to vital organs...
  42. HEMEOXYGENASE1--REGULATION AND FUNCTION AFTER HYPEROXIA
    PATTY LEE; Fiscal Year: 2002
    ..In addition, patients succumbing to respiratory failure (e.g. adult respiratory distress syndrome) require supplemental oxygen therapy which further increases the oxidant burden of the lung...
  43. ENDOTHELIAL CELL BIOLOGY FOLLOWING OXIDATIVE STRESS
    Aaron Barchowsky; Fiscal Year: 1993
    ..demonstrated during acute vascular disorders, such as ischemia/reperfusion, complement activation, adult respiratory distress syndrome, and following administration of certain antineoplastic compounds...
  44. Integrated Maglev Pump-Oxygenator for Respiratory Support
    Kurt Dasse; Fiscal Year: 2006
    ..b>Adult respiratory distress syndrome (ARDS) alone afflicts approximately 150,000 patients every year with a mortality rate between 30 ..
  45. LUNG MACROPHAGE FUNCTION IN ENDOTOXIN-INDUCED INJURY
    Charles Frevert; Fiscal Year: 1993
    b>Adult Respiratory Distress Syndrome (ARDS) is a form of acute lung injury characterized by refractory hypoxemia and high permeability pulmonary edema...
  46. MOB1, A NOVEL C-X-C CHEMOKINE--PATHOGENIC ROLE IN ARDS
    Reuven Rabinovici; Fiscal Year: 2000
    DESCRIPTION: (Adapted from the applicant's abstract) Adult respiratory distress syndrome (ARDS) is a grave complication in critically ill patients resulting in severe pulmonary dysfunction and death...
  47. LUNG LPS BINDING PROTEIN AND ARDS AFTER TRAUMA
    Richard Klein; Fiscal Year: 2000
    DESCRIPTION (Adapted from applicants' abstract) The adult respiratory distress syndrome (ARDS) is still a major cause of morbidity and mortality among trauma and critically ill patients...
  48. PATHOPHYSIOLOGY OF LUNG VASCULAR PERMEABILITY
    Rodney Rhoades; Fiscal Year: 1991
    ..dynamics and fluid transport properties, is a primary event leading to the development of edema in Adult Respiratory Distress Syndrome. The overall objective of this proposed interdisciplinary project (Biochemistry, Immunology, and ..
  49. EARLY EFFECTS OF OXYGEN ON LUNG METABOLIC FUNCTION
    David Bassett; Fiscal Year: 1999
    ..have been implicated in the pathogenesis of several different lung disorders that include adult respiratory distress syndrome. The major objective of this study is to determine how oxygen treatment might adversely affects ..
  50. Impeller optimization for a combined pump-oxygenator
    BRIAN BIANCUCCI; Fiscal Year: 2006
    ..b>Adult respiratory distress syndrome (ARDS) afflicts approximately 150,000 patients every year in the US...
  51. CHARACTERIZING NITRIC OXIDE EXCHANGE IN THE LUNGS
    STEVEN GEORGE; Fiscal Year: 2001
    ..NO holds promise as a therapy for diseases such as bronchial asthma, pulmonary hypertension, and Adult Respiratory Distress Syndrome (ARDS)...
  52. Alveolar Epithelium in Acute Lung Injury
    Lorraine Ware; Fiscal Year: 2005
    ..Combined with a compelling research project, the training will -provide the skills necessary for a successful career in biomedical research. ..
  53. Biomarker Profiles in the Diagnosis/Prognosis of ARDS
    Lorraine Ware; Fiscal Year: 2008
    ..unreadable] [unreadable]..
  54. RISK FACTORS & BIOMARKERS OF OX STRESS IN GRAFT FAILURE
    Jason Christie; Fiscal Year: 2004
    ..abstract_text> ..
  55. SCCOR in Translational Research in Acute Lung Injury
    Thomas Martin; Fiscal Year: 2007
    ..The proposed SCCOR Program will enhance understanding of the pathogenesis of lung injury and could lead to new treatments and improved long-term outcome for patients with acute lung injury. ..
  56. MOLECULAR MECHANISMS OF LUNG INFLAMMATION
    Thomas Martin; Fiscal Year: 2002
    ....
  57. Sleep Apnea and Obesity: Cardiovascular Risk Assessment
    Atul Malhotra; Fiscal Year: 2008
    ..This data may have important implications for the diagnosis and treatment of these abnormalities. ..
  58. Aging Influence on the Development of Sleep Apnea
    Atul Malhotra; Fiscal Year: 2007
    ..abstract_text> ..
  59. VENTILATOR-ASSOCIATED ALVEOLAR EPITHELIAL INJURY
    James Frank; Fiscal Year: 2006
    ..This research and comprehensive career development plan will prepare me to become an independent investigator in the mechanisms of alveolar epithelial injury and ventilator-associated lung injury. ..
  60. CONTROL OF FIBRIN TURNOVER IN PLEURAL DISEASE
    Steven Idell; Fiscal Year: 2004
    ..This work could identify better, clinically feasible therapeutic approaches to prevent pleural fibrosis. ..