- Oxidants and the pathogenesis of lung diseases
Laboratory of Respiratory Biology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
J Allergy Clin Immunol 122:456-68; quiz 469-70. 2008
- An official ATS/IDSA statement: diagnosis, treatment, and prevention of nontuberculous mycobacterial diseases
David E Griffith
Am J Respir Crit Care Med 175:367-416. 2007
- General considerations for lung function testing
M R Miller
University Hospital Birmingham NHS Trust, UK
Eur Respir J 26:153-61. 2005
- Potential significance of telocytes in the pathogenesis of lung diseases
Zhongshan Hospital, Fudan University, Shanghai, China
Expert Rev Respir Med 6:45-9. 2012
Multiple cells play critical roles in the pathogenesis of lung diseases, even though the exact mechanisms are still not clear...
- Probiotics and lung diseases
Brain Body Institute and Department of Medicine, McMaster University, Hamilton, ON, Canada
Chest 139:901-8. 2011
- Cardiovascular mortality and long-term exposure to particulate air pollution: epidemiological evidence of general pathophysiological pathways of disease
C Arden Pope
Brigham Young University, 130 FOB, Provo, UT 84602 2363, USA
Circulation 109:71-7. 2004
..Associations with specific cardiopulmonary diseases might be useful in exploring potential mechanistic pathways linking exposure and mortality...
- Targeted deletion reveals essential and overlapping functions of the miR-17 through 92 family of miRNA clusters
Center for Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
Cell 132:875-86. 2008
..These results provide key insights into the physiologic functions of this family of microRNAs and suggest a link between the oncogenic properties of miR-17 approximately 92 and its functions during B lymphopoiesis and lung development...
- Requirement of bic/microRNA-155 for normal immune function
Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK
Science 316:608-11. 2007
..Our work suggests that bic/microRNA-155 plays a key role in the homeostasis and function of the immune system...
- Rapid increase of non-tuberculous mycobacterial lung diseases at a tertiary referral hospital in South Korea
Y S Park
Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine and Lung Institute, Seoul National University College of Medicine, Seoul, Republic of Korea
Int J Tuberc Lung Dis 14:1069-71. 2010
..From 2002 to 2008, the number of patients with NTM lung diseases increased from 82 to 133, while the number of TB patients decreased from 436 to 276...
- Sex steroid receptors in human lung diseases
Mohit K Verma
Department of Pathology, Tohoku University Graduate School of Medicine, Sendai, Miyagi ken, Japan
J Steroid Biochem Mol Biol 127:216-22. 2011
..studies have reported that gender differences exist in clinical and biological manifestations of human lung diseases. In particular, women are far more likely to develop both neoplastic and non-neoplastic lung diseases than men...
- Asbestos-induced lung diseases: an update
David W Kamp
Department of Medicine, Northwestern University Feinberg School of Medicine and Jesse Brown VA Medical Center, Chicago, Ill 60611 3010, USA
Transl Res 153:143-52. 2009
..Despite a dramatic reduction in asbestos use worldwide, asbestos-induced lung diseases remain a substantial health concern primarily because of the vast amounts of fibers that have been mined, ..
- Nontuberculous mycobacterial lung disease prevalence at four integrated health care delivery systems
D Rebecca Prevots
Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
Am J Respir Crit Care Med 182:970-6. 2010
..Single-site clinic-based studies suggest an increasing prevalence of pulmonary nontuberculous mycobacteria (NTM) disease, but systematic data are lacking...
- The role of oxidative stress in ambient particulate matter-induced lung diseases and its implications in the toxicity of engineered nanoparticles
Division of NanoMedicine, Department of Medicine, University of California, Los Angeles, CA 90095, USA
Free Radic Biol Med 44:1689-99. 2008
..The importance of cellular antioxidant and detoxification pathways in protecting against particle-induced lung damage will also be discussed...
- Oxidative stress, chromatin remodeling and gene transcription in inflammation and chronic lung diseases
Respiratory Medicine, ELEGI Laboratory, MRC Centre for Inflammation Research, University of Edinburgh, Edinburgh, UK
J Biochem Mol Biol 36:95-109. 2003
Inflammatory lung diseases are characterized by chronic inflammation and oxidant/antioxidant imbalance...
- Stem cells and cell therapies in lung biology and lung diseases
Daniel J Weiss
Vermont Lung Center, University of Vermont College of Medicine, Burlington, Vermont 05405, USA
Proc Am Thorac Soc 8:223-72. 2011
..the Pulmonary Fibrosis Foundation, convened a workshop,‘‘Stem Cells and Cell Therapies in Lung Biology and Lung Diseases,’’ held July 26-29, 2009 at the University of Vermont,to review the current understanding of the role of ..
- Pulmonary nontuberculous mycobacterial disease prevalence and clinical features: an emerging public health disease
Kevin L Winthrop
Oregon Health and Science University, Portland, OR 97239, USA
Am J Respir Crit Care Med 182:977-82. 2010
..Respiratory specimens with nontuberculous mycobacteria (NTM) are increasingly common; however, pulmonary disease prevalence is unknown...
- Pseudomonas aeruginosa: host defence in lung diseases
Bryan J Williams
Pulmonary, Allergy, Critical Care and Sleep Medicine, University of Minnesota, Minneapolis, Minnesota 55455, USA
Respirology 15:1037-56. 2010
..Understanding the pathogenesis of P. aeruginosa, and the respiratory host defence response to it has, and will continue to, lead to novel therapeutic strategies to help patients...
- Air pollution and cardiovascular disease: a statement for healthcare professionals from the Expert Panel on Population and Prevention Science of the American Heart Association
Robert D Brook
Circulation 109:2655-71. 2004
..Practical recommendations for healthcare providers and their patients are outlined. In the final section, suggestions for future research are made to address a number of remaining scientific questions...
- A therapeutic role for matrix metalloproteinase inhibitors in lung diseases?
R E Vandenbroucke
Dept for Molecular Biomedical Research, VIB, Ghent University, Ghent Zwijnaarde, Belgium
Eur Respir J 38:1200-14. 2011
..in the development of pulmonary diseases such as chronic obstructive pulmonary disease, asthma, interstitial lung diseases and lung cancer...
- Very low birth weight outcomes of the National Institute of Child health and human development neonatal research network, January 1995 through December 1996. NICHD Neonatal Research Network
J A Lemons
Indiana University, Indianapolis, Indiana, USA
Pediatrics 107:E1. 2001
..To determine the mortality and morbidity for infants weighing 401 to 1500 g (very low birth weight [VLBW]) at birth by gestational age, birth weight, and gender...
- Stem cells and cell therapies in lung biology and lung diseases
Daniel J Weiss
Department of Medicine, University of Vermont College of Medicine, 149 Beaumont Avenue, HSRF 226, Burlington, VT 05405, USA
Proc Am Thorac Soc 5:637-67. 2008
- Retrospective evaluation of the clinical and radiographic risk factors associated with severe pulmonary hemorrhage in first-line advanced, unresectable non-small-cell lung cancer treated with Carboplatin and Paclitaxel plus bevacizumab
Alan B Sandler
Vanderbilt University, Nashville, TN, USA
J Clin Oncol 27:1405-12. 2009
..Retrospective case-control and cohort analyses were conducted to identify associated radiographic and clinical risk factors for PH...
- Characteristics of pulmonary cysts in Birt-Hogg-Dubé syndrome: thin-section CT findings of the chest in 12 patients
Department of Respiratory Medicine, Juntendo University, School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo 113 8421, Japan
Eur J Radiol 77:403-9. 2011
..To describe in detail the characteristic chest computed tomography (CT) findings of Birt-Hogg-Dubé (BHD) syndrome...
- Pulmonary cysts of Birt-Hogg-Dubé syndrome: a clinicopathologic and immunohistochemical study of 9 families
Department of Molecular Pathology, Yokohama City University Graduate School of Medicine, Yokohama, Japan
Am J Surg Pathol 36:589-600. 2012
..We propose a new insight, namely, that the BHD syndrome-associated pulmonary cyst may be considered a hamartoma-like cystic alveolar formation associated with deranged mTOR signaling...
- Isolation prevalence of pulmonary non-tuberculous mycobacteria in Ontario, 1997 2003
Theodore K Marras
Joint Division of Respirology, University Health Network and Mount Sinai Hospital, Department of Medicine, University of Toronto, Toronto, Canada
Thorax 62:661-6. 2007
..A study was undertaken of the "isolation prevalence" of pulmonary NTM in Ontario, Canada between 1997 and 2003 and the frequency of pulmonary NTM "disease"...
- Vascular endothelial growth factor in the lung
Norbert F Voelkel
University of Colorado Health Sciences Center, Pulmonary and Critical Care Division, 4200 E Ninth Ave, C272, Denver, CO 80262, USA
Am J Physiol Lung Cell Mol Physiol 290:L209-21. 2006
..of this protein, there is increasing evidence that VEGF also plays a role in several acute and chronic lung diseases, such as acute lung injury, severe pulmonary hypertension, and emphysema...
- Lung diseases directly associated with rheumatoid arthritis and their relationship to outcome
Department of Respiratory Medicine, Saitama Cardiovascular and Respiratory Center, 1696 Itai, Kumagaya, Saitama 360 0105, Japan
Eur Respir J 37:1411-7. 2011
..3%) died, of whom 58 (81.7%) died due to respiratory lesions. Of patients with RA-LD, patients with DAD experienced the highest mortality, and the survival of patients with UIP was worse than that of patients with NSIP...
- Lung diseases at necropsy in African children dying from respiratory illnesses: a descriptive necropsy study
University of Zambia University College London Medical School Research and Training Project, University Teaching Hospital, Lusaka, Zambia
Lancet 360:985-90. 2002
..We undertook a study of children who died from respiratory diseases at University Teaching Hospital, Lusaka, Zambia...
- NRAMP1 gene polymorphism and susceptibility to nontuberculous mycobacterial lung diseases
Won Jung Koh
Division of Pulmonary and Critical Care Medicine, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Irwon dong, Gangnam Gu, Seoul 135 710, South Korea
Chest 128:94-101. 2005
..The purpose of this study was to evaluate a potential role for natural-resistance-associated macrophage protein 1 (NRAMP1) gene polymorphisms for human susceptibility to the NTM lung disease...
- Claudins in lung diseases
Department of Pathology and Forensic Medicine, Institute of Clinical Medicine, Pathology and Forensic Medicine, School of Medicine, University of Eastern Finland, Cancer Center of Eastern Finland, PO Box 1627, FI 70211 Kuopio, Finland
Respir Res 12:70. 2011
..In this review, the significance of claudins is discussed in lung disease and development...
- Antibiotic treatment of Mycobacterium abscessus lung disease: a retrospective analysis of 65 patients
Division of Pulmonary and Critical Care Medicine, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea
Am J Respir Crit Care Med 180:896-902. 2009
..The optimal therapeutic regimen and duration of treatment for Mycobacterium abscessus lung disease is not well established...
- Long-term morbidity from severe pneumonia in early childhood in The Gambia, West Africa: a follow-up study
L M Puchalski Ritchie
University Health Network, University of Toronto, Toronto, Ontario, Canada
Int J Tuberc Lung Dis 13:527-32. 2009
..To assess long-term outcomes in severe early childhood pneumonia in The Gambia...
- Chronic lung disease in adolescents with delayed diagnosis of vertically acquired HIV infection
Rashida A Ferrand
Clinical Research Department, London School of Hygiene and Tropical Medicine, United Kingdom
Clin Infect Dis 55:145-52. 2012
..Chronic respiratory symptoms are more common than would be anticipated based on the HIV literature...
- Genetic modifiers of lung disease in cystic fibrosis
Mitchell L Drumm
Department of Pediatrics, Case Western Reserve University, Cleveland, USA
N Engl J Med 353:1443-53. 2005
..Polymorphisms in genes other than the cystic fibrosis transmembrane conductance regulator (CFTR) gene may modify the severity of pulmonary disease in patients with cystic fibrosis...
- Meta-analyses of genome-wide association studies identify multiple loci associated with pulmonary function
Dana B Hancock
Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina, USA
Nat Genet 42:45-52. 2010
..Our findings may offer insights into pulmonary function and pathogenesis of chronic lung disease...
- The inflammasome in lung diseases
Gimena Dos Santos
Division of Pulmonary and Critical Care Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
Am J Physiol Lung Cell Mol Physiol 303:L627-33. 2012
..The aim of this review is to summarize the most relevant points of inflammasome activation in lung diseases.
- Association between long-term exposure to outdoor air pollution and mortality in China: a cohort study
Cardiovascular Institute and Fu Wai Hospital of the Chinese Academy of Medical Sciences and Peking Union Medical College, and Chinese National Center for Cardiovascular Disease Control and Research, Beijing, China
J Hazard Mater 186:1594-600. 2011
..These data contribute to the scientific literature on long-term effects of air pollution for high exposure settings typical in developing countries...
- Reactive oxygen species, inflammation, and lung diseases
Di Paola Rosanna
Department of Clinical and Experimental Medicine and Pharmacology, School of Medicine, University of Messina, Via C Valeria Gazzi 98100 Messina, Italy
Curr Pharm Des 18:3889-900. 2012
..is conceivable that chronic inflammation-induced production of ROS in the lung may predispose individuals to lung diseases. In this review, we discuss mechanisms of oxidant stress in the lung, the role of oxidants in lung disease ..
- Cytokines in tolerance to hyperoxia-induced injury in the developing and adult lung
Divison of Perinatal Medicine, Department of Pediatrics, Yale University School of Medicine, New Haven, CT 06520 8064, USA
Free Radic Biol Med 41:4-18. 2006
..Designing a therapeutic approach to counteract oxygen toxicity in the adult and immature lung first needs understanding of the unique responses in each scenario...
- Augmented responses to ozone in obese carboxypeptidase E-deficient mice
Richard A Johnston
Physiology Program, Department of Environmental Health, Harvard School of Public Health, 665 Huntington Ave, Boston, MA 02115 6021, USA
Am J Physiol Regul Integr Comp Physiol 290:R126-33. 2006
..These results also suggest that chronic systemic inflammation may enhance airway responses to O3 in obese mice...
- Cost-effectiveness analysis of prophylactic respiratory physiotherapy in pulmonary lobectomy
Section of Thoracic Surgery, Salamanca University Hospital, 37007 Salamanca, Spain
Eur J Cardiothorac Surg 29:216-20. 2006
..To evaluate the cost-effectiveness balance of implementing an intensive program of chest physiotherapy in pulmonary lobectomy...
- Pseudomonas aeruginosa mutations in lasI and rhlI quorum sensing systems result in milder chronic lung infection
Department of Clinical Microbiology, 9301 Rigshospitalet, Juliane Maries Vej 22, DK-2100, , Denmark
Microbiology 147:1105-13. 2001
..The conclusion of this study is that functional lasI and rhlI genes of P. aeruginosa PAO1 play a significant role during lung infection...
- Previous lung diseases and lung cancer risk: a systematic review and meta-analysis
Darren R Brenner
Samuel Lunenfeld Research Institute of Mount Sinai Hospital, and the Dalla Lana School of Public Health, University of Toronto, Toronto, Canada
PLoS ONE 6:e17479. 2011
In order to review the epidemiologic evidence concerning previous lung diseases as risk factors for lung cancer, a meta-analysis and systematic review was conducted.
- Pathology and pathophysiology of pulmonary manifestations in leptospirosis
Department of Pathology, School of Medicine, University of Sao Paulo, SP, Brazil
Braz J Infect Dis 11:142-8. 2007
..In this review we present the main clinical and pathological manifestations of pulmonary involvement in leptospirosis, with special focus on recent data concerning the pathophysiological mechanisms underlying lung injury...
- Postnatal steroids to treat or prevent chronic lung disease in preterm infants
David J Burchfield
Pediatrics 111:221-2; author reply 221-2. 2003
- IP-10 detection in urine is associated with lung diseases
Department of Epidemiology and Preclinical Research, L Spallanzani National Institute for Infectious Diseases INMI, Rome, Italy
BMC Infect Dis 10:333. 2010
..In a subgroup, the evaluation was also performed during TB treatment and at therapy completion. Patients with lung diseases other than TB, and healthy subjects were also enrolled.
- Pulmonary Langerhans' cell histiocytosis: molecular analysis of clonality
S A Yousem
Departments of Pathology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA
Am J Surg Pathol 25:630-6. 2001
..Cigarette smoking may be the stimulus for pulmonary LCH in contrast to other forms of LCH...
- Wnt signalling in lung development and diseases
Judit E Pongracz
Department of Immunology and Biotechnology, University of Pecs, Pecs, Hungary
Respir Res 7:15. 2006
..In this review, we will present a synopsis of current Wnt research with particular attention paid to the role of Wnt signals in lung development and in pulmonary diseases...
- Leptospirosis presenting as diffuse alveolar hemorrhage: case report and literature review
Andrew M Luks
Department of Medicine Dr Luks, University of Washington, Seattle 98108, USA
Chest 123:639-43. 2003
..In the right clinical scenario, the disease should be considered in a patient presenting with diffuse alveolar hemorrhage...
- Early death due to defective neonatal lung liquid clearance in alpha-ENaC-deficient mice
Institut de Pharmacologie et de Toxicologie de l Université, Lausanne, Switzerland
Nat Genet 12:325-8. 1996
..Alpha-ENaC(-/-) neonates developed respiratory distress and died within 40 h of birth from failure to clear their lungs of liquid. This study shows that ENaC plays a critical role in the adaptation of the newborn lung to air breathing...
- Guidelines for radiologically guided lung biopsy
Department of Radiology, Nottingham City Hospital, UK
Thorax 58:920-36. 2003
- Early pulmonary involvement in ankylosing spondylitis: assessment with thin-section CT
Department of Radiology, University of Vienna, Austria
Clin Radiol 55:632-6. 2000
- Inhaled hypertonic saline as a therapy for cystic fibrosis
Mark R Elkins
Royal Prince Alfred Hospital, Australia
Curr Opin Pulm Med 12:445-52. 2006
..At that time, competing hypotheses about the pathogenesis of cystic fibrosis lung disease predicted very different responses to long-term inhalation of hypertonic saline...
- Pneumothorax in pulmonary Langerhans cell histiocytosis
Jose L Mendez
Division of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, MN 55905, USA
Chest 125:1028-32. 2004
..Pulmonary Langerhans cell histiocytosis (PLCH) is a smoking-related interstitial lung disease characterized by development of cystic changes that predispose to occurrence of pneumothorax...
- Prevalence and clinical significance of antineutrophil cytoplasmic antibodies in Churg-Strauss syndrome
Renato A Sinico
Dipartimento di Nefrologia e Immunologia, Azienda Ospedaliera Ospedale San Carlo Borromeo, Milan, Italy
Arthritis Rheum 52:2926-35. 2005
..We undertook this study to examine the prevalence and antigen specificity of ANCAs in a large cohort of patients with CSS. Moreover, we evaluated the relationship between ANCA positivity and clinicopathologic features...
- Pulmonary alveolar microlithiasis: report on 576 cases published in the literature
Dipartimento Scienze Cardiovascolare e Respiratorie, Universita La Sapienza, Azienda Policlinico Sant Andrea, UO Pneumologia, and Italy
Sarcoidosis Vasc Diffuse Lung Dis 21:173-81. 2004
..The present paper aimed to study the disorder throughout the world, emphasizing the diagnostic and therapeutic views...
- Impact of oxidative stress on lung diseases
Hee Sun Park
Department of Internal Medicine, Chungnam National University Medical School, Daejeon, Korea
Respirology 14:27-38. 2009
..Knowledge of the mechanisms of ROS regulation could lead to the pharmacological manipulation of antioxidants in lung inflammation and injury...
- The relationship between reduced lung function and cardiovascular mortality: a population-based study and a systematic review of the literature
Don D Sin
Department of Medicine, Respiratory Division, University of British Columbia, and The James Hogg iCAPTURE Center for Cardiovascular and Pulmonary Research, St Paul s Hospital, Room 368A, 1081 Burrard St, Vancouver, BC V6Z 1Y6, Canada
Chest 127:1952-9. 2005
..We sought to determine the relationship between reduced FEV1 and cardiovascular mortality, independent of smoking...
- Birt-Hogg-Dubé syndrome: diagnosis and management
Fred H Menko
Department of Clinical Genetics, VU University Medical Centre, Amsterdam, The Netherlands
Lancet Oncol 10:1199-206. 2009
..Preventive measures are aimed mainly at early diagnosis and treatment of renal cancer. This Review gives an overview of current diagnosis and management of BHD...
- The challenge of patients' unmet palliative care needs in the final stages of chronic illness
Nursing Research and Development, Belfast City Hospital, Belfast, Northern Ireland
Palliat Med 21:313-22. 2007
..There is consensus in the literature that the end of life care for patients with chronic illness is suboptimal, but research on the specific needs of this population is limited...
- Pseudomonas aeruginosa recognizes and responds aggressively to the presence of polymorphonuclear leukocytes
Department of Systems Biology, Technical University of Denmark, DK 2800 Lyngby, Denmark
Microbiology 155:3500-8. 2009
..Our data strengthen the view that cross-kingdom communication plays a key role in P. aeruginosa recognition and evasion of the host defence...
- Advances in neutrophil biology: clinical implications
Andrew S Cowburn
Respiratory Medicine Division, Department of Medicine, University of Cambridge School of Clinical Medicine, Addenbrooke s Hospital, Hills Road, Cambridge, UK
Chest 134:606-12. 2008
Many lung diseases are characterized by neutrophil-dominated inflammation; therefore, an understanding of neutrophil function is of considerable importance to respiratory physicians...
- Rheumatoid arthritis-related lung diseases: CT findings
Department of Radiology, University of Colorado Health Sciences Center, Denver, CO, USA
Radiology 232:81-91. 2004
..To evaluate computed tomographic (CT) findings of rheumatoid arthritis-related lung disease and categorize findings according to pathologic features...
- Significant involvement of CCL2 (MCP-1) in inflammatory disorders of the lung
C Edward Rose
Division of Pulmunory and Critical Care Medicine and the Division of Rheumatology and Immunology, University of Virginia School of Medicine, Charlottesville, VA 22908, USA
Microcirculation 10:273-88. 2003
- Pulmonary toxicity of single-wall carbon nanotubes in mice 7 and 90 days after intratracheal instillation
Chiu wing Lam
Space and Life Sciences, NASA Johnson Space Center, Houston, Texas 77058, USA
Toxicol Sci 77:126-34. 2004
- Lung cysts in Birt-Hogg-Dubé syndrome: histopathological characteristics and aberrant sequence repeats
Department of Pathology, Chiba University Hospital, Chiba, Japan
Pathol Int 59:720-8. 2009
..Haploinsufficiency of folliculin may cause deranged alveolar development, leading to the aberrant cystic alveolar formation. The unique mutation patterns of abnormal sequence repeats in patients with BHD syndrome are also reviewed...
- Integrating microRNAs into a system biology approach to acute lung injury
Section of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, University of Illinois at Chicago, Chicago, Ill, USA
Transl Res 157:180-90. 2011
..VILI) and the more severe acute respiratory distress syndrome (ARDS), are common and complex inflammatory lung diseases potentially affected by various genetic and nongenetic factors...
- Nontuberculous mycobacteria in non-HIV patients: epidemiology, treatment and response
M T Henry
Dept of Respiratory Medicine, Leeds General Infirmary, Leeds, UK
Eur Respir J 23:741-6. 2004
..Nontuberculous mycobacteria infections remain a significant problem in non-HIV patients. Adherence to published guidelines may improve patient outcomes...
- Vascular endothelial growth factor and related molecules in acute lung injury
Thoracic Surgery Research Laboratories, Toronto Generl Research Institute, University Health Network, Toronto, Ontario, Canada M5G 2C4
J Appl Physiol (1985) 97:1605-17. 2004
..Understanding the role of VEGF in this disease process is crucial for developing new therapeutic strategies for ALI/ARDS...
- Preoperative pulmonary risk stratification for noncardiothoracic surgery: systematic review for the American College of Physicians
Gerald W Smetana
Division of General Medicine and Primary Care, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
Ann Intern Med 144:581-95. 2006
..The importance of clinical risk factors for postoperative pulmonary complications and the value of preoperative testing to stratify risk are the subject of debate...
- Surfactant-replacement therapy for respiratory distress in the preterm and term neonate
William A Engle
Pediatrics 121:419-32. 2008
- Phosphodiesterase-4 inhibitor therapy for lung diseases
Section of Respiratory Diseases, Department of Oncology, Haematology, and Respiratory Diseases, University of Modena and Reggio Emilia, Policlinico di Modena, Modena, Italy
Am J Respir Crit Care Med 188:271-8. 2013
..is highly expressed in leukocytes and other inflammatory cells involved in the pathogenesis of inflammatory lung diseases, such as asthma and chronic obstructive pulmonary disease (COPD), inhibition of PDE4 has been predicted to ..
- Co-morbidities in established rheumatoid arthritis
Nicola J Gullick
Department of Rheumatology, King s College London School of Medicine, Weston Education Centre, United Kingdom
Best Pract Res Clin Rheumatol 25:469-83. 2011
- Therapeutic modulation of miRNA for the treatment of proinflammatory lung diseases
Respiratory Research Division, Department of Medicine, Royal College of Surgeons in Ireland, Education and Research Centre, Beaumont Hospital, Dublin 9, Ireland
Expert Rev Anti Infect Ther 10:359-68. 2012
..of aspects of innate immunity and inflammation, what happens when this goes awry, such as in the chronic inflammatory lung diseases cystic fibrosis and asthma, and discuss the current state-of-the-art miRNA-targeted therapeutics.
- Application of 'omics technologies to biomarker discovery in inflammatory lung diseases
Craig E Wheelock
Division of Physiological Chemistry II, Karolinska Institutet, Stockholm
Eur Respir J 42:802-25. 2013
Inflammatory lung diseases are highly complex in respect of pathogenesis and relationships between inflammation, clinical disease and response to treatment...
- Molecular basis of asbestos-induced lung disease
Clinical Research Center, Affiliated Hospital of Guangdong Medical College, Zhangjiang, China
Annu Rev Pathol 8:161-87. 2013
..These new insights into the molecular basis of asbestos-induced lung diseases may foster the development of novel therapeutic targets for managing degenerative diseases (e.g...
- Clinical application of exhaled nitric oxide measurement in pediatric lung diseases
Department of Pediatrics, Federico II University, Naples, Italy
Ital J Pediatr 38:74. 2012
..This review focuses on the most recent advances and the current clinical applications of FeNO measurement in pediatric lung disease...
- Immune receptors and adhesion molecules in human pulmonary leptospirosis
Fabiola Del Carlo Bernardi
Department of Pathology, University of Sao Paulo Medical School, São Paulo SP CEP 01246 903, Brazil
Hum Pathol 43:1601-10. 2012
..015). Our results indicate that immune receptors and adhesion molecules participate in the phenomena leading to pulmonary hemorrhage in leptospirosis...
- Perspectives for improving the evaluation and access of therapies for rare lung diseases in Europe
Department of Molecular Medicine, Section of Pneumology, University of Pavia, IRCCS San Matteo Hospital Foundation, Pavia, Italy
Respir Med 106:759-68. 2012
..Small patient cohorts alter clinical trial design and limit enrollment, and the picture for rare lung diseases is further complicated by the fact that most are composed of a variety of clinical phenotypes...
- Serum anti-p53 autoantibodies in pleural malignant mesothelioma, lung cancer and non-neoplastic lung diseases
Division of Environmental Epidemiology, National Cancer Research Institute, Largo Rosanna Benzi 10, I 16132 Genoa, Italy
Lung Cancer 39:165-72. 2003
..The longer survival among positive LC patients and the presence of two seropositive among patients with non-neoplastic respiratory diseases should be further investigated...
- Mutations in SLC34A2 cause pulmonary alveolar microlithiasis and are possibly associated with testicular microlithiasis
Department of Molecular Biology and Genetics, Bogazici University, Istanbul, Turkey
Am J Hum Genet 79:650-6. 2006
..In 2 of the 15 subjects with TM we studied, we identified two rare variants, one synonymous and the other noncoding, that are possibly associated with the condition...
- Clinical practice. The solitary pulmonary nodule
Center for Pulmonary and Critical Care Medicine, North Shore University Hospital, Manhasset, NY 11030, USA
N Engl J Med 348:2535-42. 2003
- The emerging role of endothelial progenitor cells in pulmonary hypertension and diffuse lung diseases
Gian Paolo Fadini
University of Padua, Department of Clinical and Experimental Medicine, Italy
Sarcoidosis Vasc Diffuse Lung Dis 24:85-93. 2007
..repair of many organs and tissues has provided new perspectives for the comprehension of the pathogenesis of lung diseases. Endothelial progenitor cells (EPCs) provide a circulating pool of cells for maintenance of the systemic and ..
- Chest radiography patterns in 75 adolescents with vertically-acquired human immunodeficiency virus (HIV) infection
S R Desai
King s College London, King s Health Partners, Department of Radiology, King s College Hospital NHS Foundation Trust, UK
Clin Radiol 66:257-63. 2011
..To evaluate lung disease on chest radiography (CR), the relative frequency of CR abnormalities, and their clinical correlates in adolescents with vertically-acquired human immunodeficiency virus (HIV) infection...
- Unusual presentation: pulmonary hemosiderosis with celiac disease and retinitis pigmentosa in a child
Pediatric Allergy and Immunology Unit, Medical Faculty, Gaziantep University, Gaziantep, Turkey
Pediatr Pulmonol 46:820-3. 2011
..We report a 9-year-old boy with Lane-Hamilton syndrome, co-occurrence of pulmonary hemosiderosis with CD. This presentation is unique presentation because he has also retinal pigmentation...
- Nitrative stress in inflammatory lung diseases
Third Department of Internal Medicine, Wakayama Medical University School of Medicine, 811 1 Kimiidera, Wakayama, Wakayama 641 0012, Japan
Nitric Oxide 25:138-44. 2011
..NO derived from the inducible type of NOS (iNOS, NOS2) in airway and lung inflammation in inflammatory lung diseases including bronchial asthma and chronic obstructive pulmonary disease (COPD) are controversial...
- Lung disease and PKCs
Edward C Dempsey
Cardiovascular Pulmonary Research Laboratory, University of Colorado Health Sciences Center, Denver, CO 80262, USA
Pharmacol Res 55:545-59. 2007
..Key isotypes of PKC involved in lung pathophysiology are summarized and current and evolving therapeutic approaches to target them are identified...
- Nrf2 defends the lung from oxidative stress
Hye Youn Cho
Laboratory of Respiratory Biology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
Antioxid Redox Signal 8:76-87. 2006
- Diffuse cystic lung disease of unexplained cause with coexistent small airway disease: a possible causal relationship?
Department of Histopathology, Royal Brompton Hospital, London, UK
Am J Surg Pathol 36:228-34. 2012
..The driving factor remains unknown...
- The rabbit as a model to study asthma and other lung diseases
Sackler Institute of Pulmonary Pharmacology, Division of Pharmaceutical Sciences, 5th Floor Hodgkin Building, King s College London, Guy s Campus, London SE1 9RT, UK
Pulm Pharmacol Ther 21:721-30. 2008
..This article highlights the usefulness of the rabbit as a species to study lung biology...
- Indoor air pollution from solid fuel use, chronic lung diseases and lung cancer in Harbin, Northeast China
Istituto di Ricerche Farmacologiche Mario Negri, 19 20156 Milan, Italy
Eur J Cancer Prev 17:473-8. 2008
..We analyzed the relationship between IAP from solid fuel use and selected chronic lung diseases and lung cancer risk in Harbin, Northeast China, an area with a very high base line risk of lung cancer for ..
- Stem cell treatment for chronic lung diseases
Department of Pneumonology, University Hospital of Alexandroupolis, Medical School, Democritus University of Thrace, Alexandroupolis, Greece
Respiration 85:179-92. 2013
Chronic lung diseases such as idiopathic pulmonary fibrosis and cystic fibrosis or chronic obstructive pulmonary disease and asthma are leading causes of morbidity and mortality worldwide with a considerable human, societal and financial ..
- Leptospirosis pulmonary haemorrhage syndrome is associated with linear deposition of immunoglobulin and complement on the alveolar surface
Laboratory of Pathology of Transmissible Diseases, Department of Pathology, Hospital das Clinicas, Faculdade de Medicina da Universidade de Sao Paulo, Sao Paulo, Brazil
Clin Microbiol Infect 16:593-9. 2010
..In the present study, it was found that the linear deposition of immunoglobulins (IgA, IgG and IgM) and complement on the alveolar surface may play a role in the pathogenesis of pulmonary haemorrhage in human leptospirosis...
- Epigenetics in asthma and other inflammatory lung diseases
Airways Disease Section, National Heart and Lung Institute, Imperial College, Dovehouse Street, London, SW3 6LY, UK
Epigenomics 2:523-37. 2010
Asthma is a chronic inflammatory disease of the airways. The causes of asthma and other inflammatory lung diseases are thought to be both environmental and heritable...
- Pulmonary features of Birt-Hogg-Dubé syndrome: cystic lesions and pulmonary histiocytoma
Pulmonary Medicine, GB Morgagni Hospital, Forli, Italy
Respir Med 105:768-74. 2011
..to describe clinical, radiologic and pathologic features of lung lesions in Birt-Hogg-Dubè syndrome (BHDS) (MIM 135150)...
- SLPI and trappin-2 as therapeutic agents to target airway serine proteases in inflammatory lung diseases: current and future directions
Marie Louise Zani
INSERM U618, Protéases et Vectorisation Pulmonaires, Faculte de Medecine, 10 Bd Tonnellé, 37032 Tours Cedex, France
Biochem Soc Trans 39:1441-6. 2011
..review examines the multifaceted roles of SLPI and elafin/trappin-2 in the context of their possible use as inhaled drugs for treating chronic lung diseases such as CF (cystic fibrosis) and COPD (chronic obstructive pulmonary disease).
- Computer-assisted detection of infectious lung diseases: a review
Center for Infectious Disease Imaging, Department of Radiology and Imaging Sciences, National Institutes of Health NIH, Bethesda, MD 20892, USA
Comput Med Imaging Graph 36:72-84. 2012
..In this paper, we review the most common radiographic and CT features of respiratory tract infections, discuss the challenges of defining and measuring these disorders with CAD, and propose some strategies to address these challenges...
- Clinical characteristics and prognosis of nontuberculous mycobacterial lung disease with different radiographic patterns
Chin Chung Shu
Department of Traumatology, Taiwan University Hospital, Taipei, Taiwan
Lung 189:467-74. 2011
..The clinical characteristics and prognostic impact of radiographic patterns of patients with nontuberculous mycobacterial lung disease (NTM-LD) are rarely evaluated...
- Early extracorporeal life support as rescue for Wegener granulomatosis with diffuse alveolar hemorrhage and acute respiratory distress syndrome: a case report and literature review
Division of Trauma and Critical Care Surgery, Department of Surgery, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC 27599 7228, USA
Pediatr Emerg Care 27:1163-6. 2011
..The study's objective was to report a case and review the literature on the use of extracorporeal life support in the face of severe pulmonary hemorrhage for acute respiratory distress syndrome...
- Pulmonary and thrombotic manifestations of systemic lupus erythematosus
Jeffrey J Swigris
Autoimmune Lung Disease Center, National Jewish Medical and Research Center, Denver, CO 80206, USA
Chest 133:271-80. 2008
..This article offers the reader a comprehensive review of the numerous pulmonary and thrombotic manifestations of SLE and suggests approaches to their management...
- Blood transfusion during cardiac surgery is associated with inflammation and coagulation in the lung: a case control study
Pieter R Tuinman
Department of Intensive Care Medicine and Laboratory of Experimental Intensive Care and Anesthesiology, Academic Medical Center, Meibergdreef 9, Amsterdam NL 1105 AZ, The Netherlands
Crit Care 15:R59. 2011
..We hypothesized that blood transfusion is associated with changes in pulmonary and systemic inflammation and coagulation occurring in patients who do not meet the clinical diagnosis of transfusion-related acute lung injury (TRALI)...