laryngeal edema

Summary

Summary: Edema of any region of the larynx from a variety of causes. In the earliest stages it may be difficult to differentiate from infection, although mucosal injection and erythema are found more often in the latter. Allergic edema may result as a response from provocation induced by foods, inhalants, and drugs. The entire respiratory tract or only an isolated portion of the larynx may be affected. Laryngeal edema may also be hereditary. Other possible causes of laryngeal edema include increased capillary pressure due to superior vena cava syndrome, internal jugular vein ligation, lowered plasma osmotic failure induced by renal failure, impaired lymphatic flow, and increased capillary permeability to proteins. (From Paparella et al., Otolaryngology, 3d ed, p2253)

Top Publications

  1. ncbi [Reinke edema--helpful in unilateral recurrent laryngeal nerve paralysis?]
    C Kothe
    Poliklinik für Hör, Stimm und Sprachheilkunde, Universitatsklinikum Hamburg Eppendorf, Germany
    HNO 51:833-5. 2003
  2. ncbi Laryngeal edema and anaphalactic shock after topical propolis use for acute pharyngitis
    Chiung Yuan Hsu
    Am J Emerg Med 22:432-3. 2004
  3. ncbi Airway obstruction following carotid endarterectomy
    O K Kwok
    Department of Anaesthesiology and Operating Theatre Services, Kwong Wah Hospital, Kowloon, Hong Kong
    Anaesth Intensive Care 32:818-20. 2004
  4. doi NTCP modeling of subacute/late laryngeal edema scored by fiberoptic examination
    Tiziana Rancati
    Prostate Program, Istituto Nazionale dei Tumori, Milan, Italy
    Int J Radiat Oncol Biol Phys 75:915-23. 2009
  5. doi Risk of laryngeal edema and facial swellings after tooth extraction in patients with hereditary angioedema with and without prophylaxis with C1 inhibitor concentrate: a retrospective study
    Konrad Bork
    Department of Dermatology, Johannes Gutenberg University, Mainz, Germany
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 112:58-64. 2011
  6. ncbi Laryngeal ultrasound: a useful method in predicting post-extubation stridor. A pilot study
    L W Ding
    Dept of Internal Medicine, National Taiwan University Hospital, Chung Shan South Road, Taipei 100, Taiwan
    Eur Respir J 27:384-9. 2006
  7. ncbi Laryngeal edema and death from asphyxiation after tooth extraction in four patients with hereditary angioedema
    Konrad Bork
    Universitäts Hautklinik, Mainz, Germany
    J Am Dent Assoc 134:1088-94. 2003
  8. ncbi 12-h pretreatment with methylprednisolone versus placebo for prevention of postextubation laryngeal oedema: a randomised double-blind trial
    Bruno Francois
    Medical Surgical Intensive Care Unit, Dupuytren Teaching Hospital, Limoges, France
    Lancet 369:1083-9. 2007
  9. ncbi Treatment of 193 episodes of laryngeal edema with C1 inhibitor concentrate in patients with hereditary angioedema
    K Bork
    Universitäts Hautklinik, Langenbeckstr 1, 55131 Mainz, Germany
    Arch Intern Med 161:714-8. 2001
  10. ncbi Post-extubation stridor in intensive care unit patients. Risk factors evaluation and importance of the cuff-leak test
    Samir Jaber
    Department of Anesthesiology, Intensive Care and Transplantation Unit DAR B, Chu de Montpellier Hopital Saint Eloi, 80, avenue Augustin Fliche, 34295 Montpellier Cedex 5, France
    Intensive Care Med 29:69-74. 2003

Detail Information

Publications221 found, 100 shown here

  1. ncbi [Reinke edema--helpful in unilateral recurrent laryngeal nerve paralysis?]
    C Kothe
    Poliklinik für Hör, Stimm und Sprachheilkunde, Universitatsklinikum Hamburg Eppendorf, Germany
    HNO 51:833-5. 2003
    ..In these cases, indication for edema surgery should be very restrictive and should always take the vocal function into consideration...
  2. ncbi Laryngeal edema and anaphalactic shock after topical propolis use for acute pharyngitis
    Chiung Yuan Hsu
    Am J Emerg Med 22:432-3. 2004
  3. ncbi Airway obstruction following carotid endarterectomy
    O K Kwok
    Department of Anaesthesiology and Operating Theatre Services, Kwong Wah Hospital, Kowloon, Hong Kong
    Anaesth Intensive Care 32:818-20. 2004
    ..Tracheostomy was performed on day 2 postoperatively. Serial fibreoptic assessment of the upper airway showed gradual resolution of glottic edema and decanulation was successful on day 43...
  4. doi NTCP modeling of subacute/late laryngeal edema scored by fiberoptic examination
    Tiziana Rancati
    Prostate Program, Istituto Nazionale dei Tumori, Milan, Italy
    Int J Radiat Oncol Biol Phys 75:915-23. 2009
    Finding best-fit parameters of normal tissue complication probability (NTCP) models for laryngeal edema after radiotherapy for head and neck cancer.
  5. doi Risk of laryngeal edema and facial swellings after tooth extraction in patients with hereditary angioedema with and without prophylaxis with C1 inhibitor concentrate: a retrospective study
    Konrad Bork
    Department of Dermatology, Johannes Gutenberg University, Mainz, Germany
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 112:58-64. 2011
    ..The aim of this study was to determine how many tooth extractions were followed by symptoms of HAE-C1-INH in patients with and without preoperative short-term prophylaxis with C1 inhibitor concentrate...
  6. ncbi Laryngeal ultrasound: a useful method in predicting post-extubation stridor. A pilot study
    L W Ding
    Dept of Internal Medicine, National Taiwan University Hospital, Chung Shan South Road, Taipei 100, Taiwan
    Eur Respir J 27:384-9. 2006
    ..The air-column width during cuff deflation was a potential predictor of post-extubation stridor...
  7. ncbi Laryngeal edema and death from asphyxiation after tooth extraction in four patients with hereditary angioedema
    Konrad Bork
    Universitäts Hautklinik, Mainz, Germany
    J Am Dent Assoc 134:1088-94. 2003
    ..Hereditary angioedema, or HAE, due to C1 inhibitor, or C1NH, deficiency has considerable implications for dental health care providers because dental surgery may trigger distressing and even life-threatening episodes...
  8. ncbi 12-h pretreatment with methylprednisolone versus placebo for prevention of postextubation laryngeal oedema: a randomised double-blind trial
    Bruno Francois
    Medical Surgical Intensive Care Unit, Dupuytren Teaching Hospital, Limoges, France
    Lancet 369:1083-9. 2007
    ..We aimed to test our hypothesis that methylprednisolone started 12 h before a planned extubation could prevent postextubation laryngeal oedema...
  9. ncbi Treatment of 193 episodes of laryngeal edema with C1 inhibitor concentrate in patients with hereditary angioedema
    K Bork
    Universitäts Hautklinik, Langenbeckstr 1, 55131 Mainz, Germany
    Arch Intern Med 161:714-8. 2001
    ..The clinical symptoms include skin swelling, abdominal pain, and life-threatening episodes of upper airway obstruction. We evaluated the efficacy of C1-INH concentrate for treating sudden airway compromise...
  10. ncbi Post-extubation stridor in intensive care unit patients. Risk factors evaluation and importance of the cuff-leak test
    Samir Jaber
    Department of Anesthesiology, Intensive Care and Transplantation Unit DAR B, Chu de Montpellier Hopital Saint Eloi, 80, avenue Augustin Fliche, 34295 Montpellier Cedex 5, France
    Intensive Care Med 29:69-74. 2003
    ..To evaluate the incidence and identify factors associated with the occurrence of post-extubation stridor and to evaluate the performance of the cuff-leak test in detecting this complication...
  11. ncbi Significance of laryngeal edema after partial laryngectomy and radiotherapy in supraglottic cancer
    Didem Colpan Oksuz
    Department of Radiation Oncology, Cerrahpasa Medical Faculty, Istanbul University, Istanbul, Turkey
    J Otolaryngol Head Neck Surg 37:681-8. 2008
    To evaluate the impact of the presence of laryngeal edema on outcome and the other potential prognostic factors in patients with supraglottic larynx carcinoma treated with radiotherapy after partial laryngectomy.
  12. ncbi The cuff-leak test is a simple tool to verify severe laryngeal edema in patients undergoing long-term mechanical ventilation
    Yu Hsiu Chung
    Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Chang Gung Memorial Hospital, Kaohsiung, Taiwan, ROC
    Crit Care Med 34:409-14. 2006
    ..test has been proposed as a simple tool to clinically predict stridor or respiratory distress secondary to laryngeal edema following extubation...
  13. ncbi Reinke's edema and risk factors: clinical and histopathologic aspects
    Dario Marcotullio
    Department of Otorhinolaryngology, La Sapienza University, Rome, Italy
    Am J Otolaryngol 23:81-4. 2002
    ..The purpose of this study was to evaluate retrospectively the distribution of histologic damage and its correlation with various risk factors in a group of patients affected by Reinke's edema...
  14. ncbi The cuff leak test to predict failure of tracheal extubation for laryngeal edema
    Yann De Bast
    Department of Intensive Care, Erasme University Hospital, Free University of Brussels, 808 route de Lennick, 1070 Brussels, Belgium
    Intensive Care Med 28:1267-72. 2002
    b>Laryngeal edema secondary to endotracheal intubation may require early re-intubation. Prior to extubation the absence of leak around an endotracheal tube may predict laryngeal edema after extubation...
  15. doi Corticosteroids for prevention of postextubation laryngeal edema in adults
    Russel J Roberts
    School of Pharmacy, Northeastern University, Boston, MA 02111, USA
    Ann Pharmacother 42:686-91. 2008
    To evaluate the efficacy and safety of prophylactic corticosteroid therapy in preventing postextubation laryngeal edema (PELE) and the need for reintubation in adults.
  16. doi Impact of image-guided radiotherapy to reduce laryngeal edema following treatment for non-laryngeal and non-hypopharyngeal head and neck cancers
    Nam P Nguyen
    Department of Radiation Oncology, University of Arizona, Tucson, AZ 85724 5081, United States
    Oral Oncol 47:900-4. 2011
    We would like to determine the effectiveness of image-guided radiotherapy (IGRT) to reduce laryngeal edema following treatment for head and neck cancer and to assess patient perception of voice and speech after treatment...
  17. pmc Prophylactic administration of parenteral steroids for preventing airway complications after extubation in adults: meta-analysis of randomised placebo controlled trials
    Tao Fan
    Pneumology Group, Department of Integrated Traditional Chinese and Western Medicine, West China Hospital, Sichuan University, Chengdu 610041, China
    BMJ 337:a1841. 2008
    ..To determine whether steroids are effective in preventing laryngeal oedema after extubation and reducing the need for subsequent reintubation in critically ill adults...
  18. ncbi The role of the cuff leak test in predicting the effects of corticosteroid treatment on postextubation stridor
    Chih Liang Wang
    Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Chang Gung Memorial Hospital, Niaosung Shiang, Kaohsiung, Taiwan, R O C
    Chang Gung Med J 30:53-61. 2007
    ..The aim of this study was to evaluate the effect of steroids on postextubation stridor based on the clinical response and the cuff leak test...
  19. ncbi Optimally fitted tracheal tubes decrease the probability of postextubation adverse events in children undergoing general anesthesia
    Pertti Suominen
    Department of Anaesthesia and Intensive Care, Hospital for Children and Adolescents, Helsinki University Central Hospital, Helsinki, Finland
    Paediatr Anaesth 16:641-7. 2006
    ..Our objectives were to determine whether there is a certain threshold air leak value beyond which a higher risk for adverse events after removal of TT can be predicted and to define other risk factors related to extubation...
  20. ncbi Exudative laryngeal diseases of Reinke's space: a clinicohistopathological framing
    Dario Marcotullio
    Department of Otolaryngology, Policlinico Umberto I, La Sapienza University, Rome, Italy
    J Otolaryngol 31:376-80. 2002
    ....
  21. ncbi Extracellular matrix of Reinke's space in some pathological conditions
    Santa Vecerina Volić
    ENT Department, Phoniatric Centre, Zagreb School of Medicine, Zagreb, Croatia
    Acta Otolaryngol 124:505-8. 2004
    ..As Reinke's oedema (RO) is characterized by excessive ECM in RS, we investigated the cell activity in RO tissue which is possibly responsible for excessive ECM production...
  22. ncbi Histological and electron microscopic investigation of Reinke's edema
    Piotr Pastuszek
    Department of Otolaryngology, Medical University, Wrocław
    Pol J Pathol 54:61-4. 2003
    ..0042, p=0.0021). Electron microscopic investigations revealed loosened intercellular junctions and widening of intercellular spaces, especially in basal and spinous layers...
  23. ncbi Voice analysis of patients with diverse types of Reinke's edema and clinical use of electroglottographic measurements
    Jae Yol Lim
    Department of Otorhinolaryngology, Institute of Logopedics and Phoniatrics, Yongdong Severance Hospital, Yonsei University College of Medicine, Seoul, South Korea
    Acta Otolaryngol 126:62-9. 2006
    ..Reinke's edema shows a variety of clinical patterns and differences in voice analysis depending on its type. Electroglottographic measurements help to objectively assess the severity of edema and voice quality before and after surgery...
  24. doi Disarrangement of collagen fibers in Reinke's edema
    Flavio Akira Sakae
    Department of Otolaryngology, The University of São Paulo School of Medicine, Sao Paulo, Brazil
    Laryngoscope 118:1500-3. 2008
    ..To describe the arrangement of collagen fibers in the superficial layer of the lamina propria of the vocal folds with Reinke' edema...
  25. ncbi One-year follow-up results of combined use of CO2 laser and cold instrumentation for Reinke's edema surgery in professional voice users
    Gursel Dursun
    Department of Otorhinolaryngology Head and Neck Surgery, Faculty of Medicine, University of Ankara, Ankara, Turkey
    Eur Arch Otorhinolaryngol 264:1027-32. 2007
    ..However, it does not imply that our method is superior to others', but this procedure constitutes an effective treatment of choice for Reinke's edema patients, including professional voice users...
  26. ncbi Dosimetric predictors of laryngeal edema
    Giuseppe Sanguineti
    Department of Radiation Oncology, University of Texas Medical Branch, Galveston, TX 77555 0711, USA
    Int J Radiat Oncol Biol Phys 68:741-9. 2007
    To investigate dosimetric predictors of laryngeal edema after radiotherapy (RT).
  27. ncbi Management of common voice problems: Committee report
    Steven M Zeitels
    Department of Otology and Laryngology, Harvard Medical School, and the Division of Laryngology, Massachusetts Eye and Ear Infirmary, Boston, MA 02114, USA
    Otolaryngol Head Neck Surg 126:333-48. 2002
    ..This report provides the reader with a state-of-the-art update on a number of common voice problems that require phonosurgical intervention...
  28. ncbi Exudative lesions of Reinke's space. An anatomopathological correlation
    M Remacle
    Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital of Louvain at Mont-Godinne, Yvoir, Belgium
    Acta Otorhinolaryngol Belg 50:253-64. 1996
    ..which determine the onset of either one or other lesion...
  29. ncbi [Severe laryngeal edema after tracheal extubation--report of a case]
    M Sato
    Department of Surgery and Department of Anesthesiology, National Cancer Center Hospital, Tokyo 104-0045
    Masui 50:1236-8. 2001
    ..Severe laryngeal edema was found by bronchofiberscopy...
  30. ncbi Laryngeal findings in users of combination corticosteroid and bronchodilator therapy
    Natasha Mirza
    Department of Otolaryngology Head and Neck Surgery, University of Pennsylvania Medical Center, Philadelphia, PA, USA
    Laryngoscope 114:1566-9. 2004
    ....
  31. ncbi Diagnostic sensitivity and specificity of laryngoscopic signs of reflux laryngitis
    Ruta Pribuisiene
    Department of Otorhinolaryngology, Kaunas University of Medicine, Eiveniu 2, 50009 Kaunas, Lithuania
    Medicina (Kaunas) 44:280-7. 2008
    ..To assess the diagnostic sensitivity and specificity of the laryngoscopic signs of reflux laryngitis...
  32. doi Vocal nodules and edema may be due to vibration-induced rises in capillary pressure
    Lukasz Czerwonka
    Department of Surgery, Division of Otolaryngology Head and Neck Surgery, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin 53706, USA
    Laryngoscope 118:748-52. 2008
    ..Vocal fold vibration may physically raise intravascular pressure to levels high enough to damage capillaries and result in leakage of erythrocytes. This type of injury is commonly seen in benign vocal fold lesions and is not well explained...
  33. ncbi [Postoperative laryngeal edema presumably due to hypoalbuminemia causing acute airway obstruction after extubation in a patient after nephrectomy]
    Koji Nakamura
    Department of Anesthesiology, Gunma University Graduate School of Medicine, Maebashi 371 8511, Japan
    Masui 53:906-9. 2004
    ..cord and extending up- and down-wards to the trachea, indicating that the obstruction is caused by severe laryngeal edema. We believe that edema may have been caused by hypoalbuminemia (1.3 g x dl(-1)) at the end of operation...
  34. ncbi Postextubation adverse events in children undergoing general anesthesia
    Dario Galante
    Paediatr Anaesth 17:192; author reply 193. 2007
  35. ncbi Best evidence in critical care medicine. Steroids to prevent post-extubation airway obstruction in adult critically ill patients
    Sean M Bagshaw
    University of Alberta Hospital, University of Alberta, Edmonton, Alberta, Canada
    Can J Anaesth 55:382-5. 2008
  36. ncbi Rheumatoid nodules and reflux disease
    Mary Es Beaver
    Texas Voice Center, Houston, USA
    Ear Nose Throat J 83:309. 2004
  37. ncbi [Assessment of voice in patients with Reinke's oedemas treated with laser microsurgery]
    Agata Szkiełkowska
    Klinika Foniatrii IFPS w Warszawie
    Otolaryngol Pol 62:82-7. 2008
    ..The results of our study show relationship between quality of voice after surgery and the stage of evolution of Reinke's oedemas according to the applied classification...
  38. ncbi Management dilemmas in laryngeal trauma
    S Y Hwang
    Department of Otolaryngology, Tan Tock Seng Hospital, Singapore
    J Laryngol Otol 118:325-8. 2004
    ..Methods of airway control, usage of investigations and the role of stents or plates in surgical management are reviewed. It is important not to delay treatment due to the poor voice and airway outcome of chronic laryngeal stenosis...
  39. ncbi Dysprosody nonassociated with neurological diseases--a case report
    Jose Antonio Pinto
    Núcleo de Otorrinolaringologia e Cirurgia de Cabeça e Pescoço de São Paulo, Sau Paulo, Brazil
    J Voice 18:90-6. 2004
    ..It is about a female patient with bilateral III degree Reinke's edema and normal neurological examinations that started presenting characteristics of the German dialect following a larynx microsurgery...
  40. ncbi Measuring edema in irradiated head and neck cancer patients
    Joanne M Patterson
    Department of Surgical and Reproductive Sciences, University of Newcastle, Newcastle upon Tyne, United Kingdom
    Ann Otol Rhinol Laryngol 116:559-64. 2007
    ..These lack the sensitivity to record edema in specific laryngo-pharyngeal structures. The aim of this study was to develop a rating scale to measure edema in the larynx and pharynx...
  41. ncbi Postoperative airway obstruction: a complication of a previously undiagnosed hypothyroidism
    Guido Benfari
    Department of Otolaryngology, G Ferreri La Sapeinza University, Rome Italy
    Otolaryngol Head Neck Surg 132:343-4. 2005
  42. ncbi Laryngeal oedema complicating extubation
    B Holst
    Anaesthesia 62:199-200. 2007
  43. ncbi [Long-term results after microlaryngoscopic removal of Reinke's edema]
    C Sommer
    Klinik für Hals Nasen Ohrenheilkunde, Kopf und Halschirurgie, Plastische Operationen, Phoniatrie und Padaudiologie, Städtische Kliniken Neuss
    HNO 55:365-74. 2007
    ..Whether and to what degree surgical intervention leads to the desired postoperative results is therefore still an open question. Therefore we conducted a follow-up study to review our own treatment results...
  44. ncbi Differential gene expression profiling of vocal fold polyps and Reinke's edema by complementary DNA microarray
    Suzy M Duflo
    Division of Otolaryngology Head and Neck Surgery, Department of Surgery, School of Medicine, The University of Utah, Salt Lake City, Utah, USA
    Ann Otol Rhinol Laryngol 115:703-14. 2006
    ..Established transcript profiles can provide insight into the molecular and cellular processes involved in these diseases...
  45. ncbi Multiple laryngeal foreign bodies composed of dried fish vertebral bones: a case report
    M Nakahira
    Department of Otolaryngology, Kochi Medical School, Nankoku, Kochi, Japan
    J Laryngol Otol 120:976-8. 2006
    ....
  46. ncbi [Quincke's edema: diagnosis and management of 102 patients with sudden upper airway obstruction]
    K Stelter
    Klinik und Poliklinik für Hals Nasen Ohrenheilkunde der Ludwig Maximilians Universität München
    Laryngorhinootologie 86:416-9. 2007
    ..rare and clinically characterized by recurrent and self-limiting skin, intestinal and life threatening laryngeal edema. Because of the danger of asphyxiation, it is vital that acute attacks of laryngeal edema be interrupted ..
  47. ncbi Difficult airway management after carotid endarterectomy: utility and limitations of the Laryngeal Mask Airway
    John G Augoustides
    Department of Anesthesiology and Critical Care, University of Pennsylvania Health System, Philadelphia, PA 19104 4283, USA
    J Clin Anesth 19:218-21. 2007
    ..In the second case, laryngeal mask airway rescue was unsuccessful, necessitating percutaneous transtracheal jet ventilation and subsequent endotracheal intubation with direct laryngoscopy...
  48. ncbi Hereditary angioneurotic edema of the larynx
    Young Chang Lim
    Department of Otorhinolaryngology Head and Neck Surgery, College of Medicine, Konkuk University, Seoul, South Korea
    Acta Otolaryngol 125:1240-3. 2005
    ..If not recognized promptly and treated properly the disease can result in a fatal outcome as it causes laryngeal edema, which can lead to a life-threatening acute upper airway obstruction...
  49. ncbi Successful intubation of a reconstructed trachea using the Parker Flex-Tip tube
    H Ito
    Acta Anaesthesiol Scand 50:901. 2006
  50. ncbi Anesthetic implications of Reinke's edema of vocal cords
    S S Moorthy
    Can J Anaesth 52:775-6. 2005
  51. ncbi Cricothyroidotomy: a short-term measure for elective ventilation in a patient with challenging neck anatomy
    H G W Paw
    Intensive Care Unit, York Hospital, United Kingdom
    Anaesth Intensive Care 34:384-7. 2006
    ..Surgical tracheostomy was considered the preferred option, but this was deemed impossible due to the challenging neck anatomy in this case...
  52. ncbi Polyps and Reinke's edema: distinct laryngeal pathologies with different potential for glottic airway obstruction
    Lucian Sulica
    Anesth Analg 100:1863; author reply 1863-4. 2005
  53. ncbi Percutaneous transtracheal jet ventilation as a guide to tracheal intubation in severe upper airway obstruction from supraglottic oedema
    K Chandradeva
    Magill Department of Anaesthesia, Queen Mary s Hospital, Sidcup DA14 6LT, UK
    Br J Anaesth 94:683-6. 2005
    ..We believe that the PTJV should be considered in the emergency management of severe upper airway obstruction when this involves supraglottic oedema...
  54. ncbi Local and systemic effects of intralaryngeal injection of cidofovir in a canine model
    Dinesh K Chhetri
    Division of Head and Nack Surgery, University of California Los Angeles School of Medicine, 90095, USA
    Laryngoscope 113:1922-6. 2003
    ..The safety of intralaryngeal injection of cidofovir remains a concern. Our goal was to evaluate local and systemic effects of intralaryngeal injection of cidofovir...
  55. ncbi Pharyngolaryngeal lesions in patients undergoing cervical spine surgery through the anterior approach: contribution of methylprednisolone
    M Pedram
    Unité de Pathologie Rachidienne, Place Amelie Raba Leon, Hopital Pellegrin Tripode, CHU Bordeaux, 33000 Bordeaux, France
    Eur Spine J 12:84-90. 2003
    ..The results of this study indicate that ENT complications of anterior cervical spinal surgery are diminished by administration of Mp. Systematic ENT examination is warranted before this type of operation...
  56. ncbi Fibronectin: an interesting vocal fold protein
    Scot D Hirschi
    University of Utah Medical School, Salt Lake City 84123, USA
    J Voice 16:310-6. 2002
    ..Lastly, it discusses preliminary microarray data that show gene expression for fibronectin to be upregulated in true vocal folds when compared to false vocal folds...
  57. ncbi The validity and reliability of the reflux finding score (RFS)
    P C Belafsky
    Center for Voice Disorders of Wake Forest University, WFU School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157-1034
    Laryngoscope 111:1313-7. 2001
    ..001). The correlation coefficient for interobserver variability was 0.90 (P <.001). CONCLUSIONS: The RFS accurately documents treatment efficacy in patients with LPR. It demonstrates excellent inter- and intraobserver reproducibility...
  58. ncbi Steroid injection for Reinke's edema using fiberoptic laryngeal surgery
    Ichiro Tateya
    Department of Otolaryngology Head and Neck Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    Acta Otolaryngol 123:417-20. 2003
    ..The aim of this study was to retrospectively assess the usefulness of this treatment method in 44 patients with mild Reinke's edema...
  59. ncbi Laryngeal edema: perioperative nursing considerations
    Marijo Letizia
    Loyola University, Chicago, IL, USA
    Medsurg Nurs 12:111-5. 2003
    b>Laryngeal edema is a relatively rare yet serious postoperative complication for those patients undergoing general anesthesia. Maintenance of airway and breathing are always the first priority of perioperative patient care...
  60. ncbi Laryngeal pseudosulcus as a predictor of laryngopharyngeal reflux
    C Hickson
    Department of Otolaryngology--Head and Neck Surgery, University of Texas Health Science Center, San Antonio, Texas 78229-3900, USA
    Laryngoscope 111:1742-5. 2001
    ..Pseudosulcus is infraglottic laryngeal edema that is thought to be secondary to LPR...
  61. ncbi The potential of virtual laryngoscopy in the assessment of vocal cord lesions
    P Walshe
    Department of Otolaryngology Head, Tallaght Hospital, Dublin, Ireland
    Clin Otolaryngol Allied Sci 27:98-100. 2002
    ..Its disadvantages are that it does not provide histology, it requires an air-mucosa interface to produce an image and it cannot identify functional lesions of the vocal cords...
  62. ncbi [Influence of voice onset on the perceptual analysis of dysphonia]
    J Revis
    Laboratoire d Audio Phonologie Clinique, Marseille, France
    Folia Phoniatr Logop 54:19-25. 2002
    ..Voice onset would be of major importance for intermediate dysphonia (G1, G2), whereas it seems not to exert any influence in the case of normal voices (G0) or severe dysphonia (G3)...
  63. ncbi [Importance of voice quality evaluation in the assessment of treatment outcome after endolaryngeal microsurgery]
    Nora Siupsinskiene
    Clinic of Othorhinolaryngology, Kaunas University of Medicine Hospital, Eiveniu 2, Lithuania
    Medicina (Kaunas) 38:1183-91. 2002
    ..8% (51) and 53.8% (43). The best results were for patients with vocal cords polyps. The complex voice assessment may be useful for evaluation of voice function recovery and efficacy of surgical treatment...
  64. ncbi [Non-invasive continuous positive airways pressure for post-extubation laryngitis in pediatric patients]
    J A Rodriguez
    Facultad de Medicina Universidad de Chile, Santiago Chile
    Arch Bronconeumol 38:463-7. 2002
    Post-extubation laryngeal edema (PLE) is a common complication (10-15%) in pediatric intensive care units, and some authors have reported high failure rates for conventional treatment.
  65. ncbi Laryngeal and other otolaryngologic manifestations of Crohn's disease
    Jane Yang
    Department of Otolaryngology Head and Neck Surgery, Thomas Jefferson University Veterans Affairs Hospital Wilmington, Delaware, USA
    J Voice 16:278-82. 2002
    ..Findings are nonspecific, primarily edema and ulcerations, and may be confused with a multitude of other disease processes. Awareness of these manifestations in the head and neck will prevent misdiagnosis or a delay in diagnosis...
  66. ncbi [Forced inspiration. A useful criterium in diagnosis of Reinke edema?]
    C Kothe
    Abteilung für Hör, Stimm und Sprachheilkunde, Universitatsklinikum Hamburg Eppendorf, Martinistrasse 52, 20246 Hamburg
    HNO 50:756-7. 2002
  67. doi Hereditary angioedema in childhood: an approach to management
    Didier G Ebo
    Department of Immunology, Allergology and Rheumatology, University Hospital Antwerp, Antwerp University, Universiteitsplein 1, Antwerp, Belgium
    Paediatr Drugs 12:257-68. 2010
    ..pruritus or urticaria, the presence of recurrent gastrointestinal attacks of colic, and episodes of laryngeal edema. Estrogens may exacerbate attacks, and in some patients attacks are precipitated by trauma, inflammation, or ..
  68. doi Fatal anaphylaxis to indoor native fire ant stings in an infant
    Daniel R More
    Department of Allergy and Immunology, Luke AFB, Arizona 85309, USA
    Am J Forensic Med Pathol 29:62-3. 2008
    ..Examination of the respiratory system was notable for congested parenchyma and mild laryngeal edema. Laboratory studies revealed an elevated tryptase of 23.9 ng/mL and radioallergosorbent test (RAST) of 1...
  69. ncbi Recurrent laryngeal nerve identification and assessment during thyroid surgery: laryngeal palpation
    Gregory W Randolph
    Department of Otology and Laryngology, Harvard Medical School, 243 Charles Street, Boston, Massachusetts 02114, USA
    World J Surg 28:755-60. 2004
    ..There were no palpation-induced laryngeal injuries or laryngeal edema. There were also no RLN injuries due to repetitive neural stimulation...
  70. doi The anesthetic considerations of tracheobronchial foreign bodies in children: a literature review of 12,979 cases
    Christina W Fidkowski
    Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, MA 02114, USA
    Anesth Analg 111:1016-25. 2010
    ..Major complications include severe laryngeal edema or bronchospasm requiring tracheotomy or reintubation, pneumothorax, pneumomediastinum, cardiac arrest, ..
  71. ncbi Radiotherapy after partial laryngectomy: an analysis of 36 cases and a proposal to optimize radiotherapy
    Elisabetta Garibaldi
    Radiotherapy Unit, Istituto per la Ricerca e Cura del Cancro IRCC, Candiolo and Mauriziano Umberto I Hospital, Turin, Italy
    Tumori 95:198-206. 2009
    ..The aim of this retrospective study was to evaluate the toxicity, local-regional control and overall survival of adjuvant radiotherapy after conservative surgery...
  72. ncbi Synchronous airway lesions and esophagitis in young patients undergoing adenoidectomy
    David L Mandell
    Division of Pediatric Otolaryngology, Children s Hospital of Pittsburgh, PA 15213, USA
    Arch Otolaryngol Head Neck Surg 133:375-8. 2007
    ..To determine the prevalence of synchronous airway lesions and esophagitis in children younger than 18 months undergoing adenoidectomy for adenoid hypertrophy and upper airway obstruction...
  73. ncbi Heparin-induced anaphylactic and anaphylactoid reactions: two distinct but overlapping syndromes
    Theodore E Warkentin
    Department of Pathology and Molecular Medicine, McMaster University, Hamilton Health Sciences, General Site, Hamilton, Ontario, Canada
    Expert Opin Drug Saf 8:129-44. 2009
    ..However, heparin-induced anaphylactoid reactions also have been reported to be a consequence of immune-mediated heparin-induced thrombocytopenia (HIT)...
  74. ncbi Idiopatic angioedema treated with dapsone
    P Gonzalez
    Hospital General de Alicante, Alicante, Spain
    Allergol Immunopathol (Madr) 33:54-6. 2005
    ..Treatment depends on identification of the causative agent and, especially when the mechanism is not identified, on the clinicians knowledge and experience with innovative therapeutic regimens...
  75. ncbi Recurrent episodes of skin angioedema and severe attacks of abdominal pain induced by oral contraceptives or hormone replacement therapy
    Konrad Bork
    Department of Dermatology, Johannes Gutenberg University, Langenbeckstrasse 1, 55131 Mainz, Germany
    Am J Med 114:294-8. 2003
    Recurrent angioedema, characterized by skin swelling, colicky attacks of abdominal pain, and life-threatening laryngeal edema, can be either hereditary or acquired...
  76. ncbi Methylene blue for clinical anaphylaxis treatment: a case report
    Janine Moreira Rodrigues
    Department of Surgery and Anatomy, Faculdade de Medicina de Ribeirao Preto, Universidade de Sao Paulo, Ribeirao Preto, Sao Paulo, CEP 14015 120, Brazil
    Sao Paulo Med J 125:60-2. 2007
    ..The aim here was to report an anaphylaxis case (not anaphylactic shock), reversed by methylene blue (MB), a guanylyl cyclase inhibitor...
  77. pmc A complicated hospitalization following dilute ammonium chloride ingestion
    Kendra Hammond
    Department of Medicine, Evanston Hospital, and Northwestern University Medical School, Evanston, IL, USA
    J Med Toxicol 5:218-22. 2009
    ..5%) cleaning solutions containing ammonium chloride typically do not cause serious harm. We present a case of an intentional ingestion of a dilute ammonium chloride solution resulting in significant morbidity...
  78. doi C1-inhibitor concentrate for individual replacement therapy in patients with severe hereditary angioedema refractory to danazol prophylaxis
    Wolfhart Kreuz
    Department of Haematology, Johann Wolfgang Goethe University Hospital, Centre of Paediatrics III, Frankfurt am Main, Germany
    Transfusion 49:1987-95. 2009
    ..In cases of laryngeal edema that are not treated immediately, HAE is associated with high mortality rates. Attenuated androgens (e.g...
  79. pmc Increased activity of coagulation factor XII (Hageman factor) causes hereditary angioedema type III
    Sven Cichon
    Department of Genomics, Life and Brain Center, University of Bonn, Bonn, Germany
    Am J Hum Genet 79:1098-104. 2006
    ..characterized clinically by recurrent acute skin swelling, abdominal pain, and potentially life-threatening laryngeal edema. Three forms of HAE have been described...
  80. ncbi The endotracheal tube cuff-leak test as a predictor for postextubation stridor
    Eric J Kriner
    Section of Respiratory Therapy, Washington Hospital Center, DC 20010, USA
    Respir Care 50:1632-8. 2005
    The endotracheal tube (ETT) cuff-leak test (CLT) has been proposed as a relatively simple, noninvasive method for detecting the presence of laryngeal edema prior to tracheal extubation.
  81. ncbi Adverse reactions of fluorescein angiography: a prospective study
    Rodrigo Pessoa Cavalcanti Lira
    Universidade Estadual de Campinas, Campinas, SP, Brasil
    Arq Bras Oftalmol 70:615-8. 2007
    ....
  82. ncbi Allergic reactions to drugs: implications for perioperative care
    Julie A Golembiewski
    Department of Pharmacy Practice, University of Illinois at Chicago College of Pharmacy, Chicago, IL 60612, USA
    J Perianesth Nurs 17:393-8. 2002
    ..Clinical manifestations of allergic reactions range from urticaria and rash to bronchoconstriction, laryngeal edema, hematologic disorders, and other serious reactions...
  83. ncbi Combined use of endoscopic CO2 laser excision of a marginal laryngeal tumor, radical neck dissection, and perioperative laterofixation of the opposite vocal cord
    M Csanady
    Department of Otorhinolaryngology, Head and Neck Surgery, , Szeged, Hungary
    Eur Arch Otorhinolaryngol 257:276-8. 2000
    ..severe inspiratory dyspnea developed because of the surgical intervention on the right side causing moderate laryngeal edema and limited movement of the right vocal cord in addition to the paralyzed left side...
  84. ncbi [Anesthetic management of laser surgery using PCPS for tracheal tumor]
    Yosuke Kuzukawa
    Department Anesthesiology, Osaka Medical College, Takatsuki 569 8686
    Masui 59:744-8. 2010
    ..Although desaturation due to unsuccessful venous drainage and difficult ventilation by laryngeal edema during the operation and tracheal obstruction by a clot after the operation was observed, the patient's ..
  85. ncbi Ingested gastrointestinal foreign bodies: predisposing factors for complications in children having surgical or endoscopic removal
    Baran Tokar
    Department of Pediatric Surgery, Eskisehir Osmangazi University, Medical School, OGU Tip Fakultesi Meselik, Eskisehir, 26480, Turkey
    Pediatr Surg Int 23:135-9. 2007
    ..laceration and bleeding, complete esophageal obstruction, caustic injury, severe esophageal stricture, laryngeal edema, recurrent aspiration pneumonia, loss of weight, intestinal perforation, constipation and intestinal ..
  86. ncbi Urgent awake tracheotomy for impending airway obstruction
    Heng Wai Yuen
    Department of Otolaryngology, Tan Tock Seng Hospital, Jalan Tan Tock Seng, Singapore
    Otolaryngol Head Neck Surg 136:838-42. 2007
    ..Few studies to date have addressed the issues surrounding awake tracheotomy. We sought to review the indications, complications, and outcome of awake tracheotomy for urgent airway control...
  87. ncbi Laryngeal disorders in patients with gastroesophageal reflux disease
    F Farrokhi
    Division of Gastroenterology and Hepatology, Center for Swallowing and Esophageal Disorders, Vanderbilt University Medical Center, Nashville, TN, USA
    Minerva Gastroenterol Dietol 53:181-7. 2007
    ..diagnosis of LPR is usually made on the basis of presenting symptoms and associated laryngeal signs including laryngeal edema and erythema...
  88. ncbi Laryngeal manifestations of gastroesophageal reflux disease
    Michael F Vaezi
    Division of Gastroenterology and Hepatology, Center for Swallowing and Esophageal Disorders, Vanderbilt University Medical Center, C2104 MCN, Nashville, TN 37232, USA
    Curr Gastroenterol Rep 10:271-7. 2008
    ..of LPR is usually made on the basis of presenting symptoms and associated laryngeal signs, including laryngeal edema and erythema...
  89. ncbi Cutaneous manifestations of anthrax in Eastern Anatolia: a review of 39 cases
    Hasan Irmak
    Department of Infectious Diseases, Yuzuncu Yil University School of Medicine, Van, Turkey
    Acta Med Okayama 57:235-40. 2003
    ..One patient with cervical edema (2.5%) died as a result of laryngeal edema and sepsis syndrome...
  90. ncbi Management of the difficult adult airway. With special emphasis on awake tracheal intubation
    J L Benumof
    Department of Anesthesia, University of California, San Diego School of Medicine 92093
    Anesthesiology 75:1087-110. 1991
    ..to be difficult, many repeated attempts at intubation should be avoided because progressive development of laryngeal edema and hemorrhage will develop and the ability to ventilate the lungs via mask consequently may be lost...
  91. doi Preservation of the external jugular venous drainage system in neck dissection
    Man Ki Chung
    Department of Otorhinolaryngology Head and Neck Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
    Otolaryngol Head Neck Surg 141:730-6. 2009
    ..To investigate whether preserving the external jugular vein (EJV) in neck dissection reduces postoperative edema of the face and neck...
  92. pmc Cardiac diphtheria in a previously immunized individual
    Loreli Munford
    Medical College of Virginia, Virginia Commonwealth University, USA
    J Natl Med Assoc 95:875-8. 2003
    ..The patient was found to have laryngeal edema on exam with greenish-black, necrotic-looking tissue extending to the hypopharynx, nasopharynx, and ..
  93. doi Benefits and risks of danazol in hereditary angioedema: a long-term survey of 118 patients
    Konrad Bork
    Department of Dermatology, Johannes Gutenberg University, Mainz, Germany
    Ann Allergy Asthma Immunol 100:153-61. 2008
    ..Treatment with androgens prevents attacks for those with this condition...
  94. ncbi Management of the difficult airway: alternative airway techniques and adjuncts
    Kenneth H Butler
    Emergency Medicine Residency Program, Division of Emergency Medicine, Department of Surgery, University of Maryland School of Medicine, 419 West Redwood Street, Suite 280, Baltimore, MD 21201, USA
    Emerg Med Clin North Am 21:259-89. 2003
    ..Each repeated attempt increases the likelihood of bleeding, oral, pharyngeal, and laryngeal edema, and malposition, causing decreased visualization of the glottic opening, equipment failure, and hypoxia...
  95. ncbi Angioedema from angiotensin-converting enzyme (ACE) inhibitor treated with complement 1 (C1) inhibitor concentrate
    E W Nielsen
    Department of Anesthesiology, Nordland Hospital and University of Tromsø, Tromsø, Norway
    Acta Anaesthesiol Scand 50:120-2. 2006
    ..Up to seven in every 1000 patients experience angioedema from angiotensin-converting enzyme (ACE) inhibitors, even after many years of use. In 2003, every 20th Norwegian used an ACE inhibitor...
  96. doi Hereditary angioedema caused by missense mutations in the factor XII gene: clinical features, trigger factors, and therapy
    Konrad Bork
    Department of Dermatology, Johannes Gutenberg University, Langenbeckstr 1, Mainz 55131, Germany
    J Allergy Clin Immunol 124:129-34. 2009
    ..Hereditary angioedema caused by mutations in the factor XII gene is a recently described disease entity that occurs mainly in women. It differs from hereditary angioedema caused by C1 inhibitor deficiency...
  97. ncbi Hereditary angioedema: a case study
    Vincent M Vacca
    Neuroscience Intensive Care Unit, Brigham and Women s Hospital, Boston, MA, USA
    J Neurosci Nurs 39:311-5. 2007
    ..The symptoms of an attack range from abdominal discomfort to a swelling of the upper extremities to a laryngeal edema that can lead to severe airway obstruction...
  98. ncbi Safety of the new selective cyclooxygenase type 2 inhibitors rofecoxib and celecoxib in patients with anaphylactoid reactions to nonsteroidal anti-inflammatory drugs
    Joaquin Quiralte
    Unidad de Alergia, Complejo Hospitalario de Jaen, Jaen, Spain
    Ann Allergy Asthma Immunol 93:360-4. 2004
    ..Controlled oral challenge with nonsteroidal anti-inflammatory drugs (NSAIDs) is the only definite way to detect safe NSAIDs in patients with NSAID-induced anaphylactoid reactions...
  99. ncbi Hereditary angioedema: a decade of human C1-inhibitor concentrate therapy
    Henriette Farkas
    Semmelweis University, Faculty of Medicine, 3rd Department of Internal Medicine, Budapest, Hungary
    J Allergy Clin Immunol 120:941-7. 2007
    ..The optional therapy for the acute management of HAE is administration of human C1-INH (hC1-INH) concentrate. However, hC1-INH is not available in many countries, in which case fresh frozen plasma is an alternative...
  100. ncbi Foramen magnum tumors: a series of 30 cases
    P Sarat Chandra
    Department of Neurosurgery, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110 029, India
    Neurol India 51:193-6. 2003
    ..Foramen magnum tumors, especially those located ventrally, are surgically challenging. We studied clinical and surgical details of extramedullary tumors located in the region of the foramen magnum...
  101. doi Hereditary angioedema in a family presenting as transient periarthritis
    Leena G Adhikesavan
    Department of Rheumatology, Geisinger Medical Center, Danville, PA 17822, USA
    J Clin Rheumatol 14:289-91. 2008
    ..This disease can cause life threatening laryngeal edema if it involves the airway...

Research Grants4

  1. RHINOVIRUS MEDIATED TRANSCRIPTION IN AIRWAY INFLAMMATION
    Bruce Zuraw; Fiscal Year: 2002
    ..These results will provide a necessary foundation for additional investigations into downstream inflammatory consequences of rhinovirus infection as well as potential targets for new intervention strategies. ..
  2. GILZ Controls TLR-Induced NF-kB Activity In Acute Asthma
    Bruce Zuraw; Fiscal Year: 2008
    ..We anticipate that this proposal will provide novel and clinically relevant data regarding the mechanisms of acute asthma exacerbations. ..
  3. The effects of strain on vocal fold fibroblasts
    Ryan Branski; Fiscal Year: 2004
    ..Furthermore, it seeks to provide in vitro data in conjunction with the Sponsor's current NIH ROI. ..
  4. Reflux Disease in Patients with Throat Signs/Symptoms
    Michael Vaezi; Fiscal Year: 2005
    ..These methods will be employed pre- and post-therapy on all patients to assess their potential clinical utility, especially in those unresponsive to medical therapy after aggressive acid suppression. ..