bronchiectasis

Summary

Summary: Persistent abnormal dilatation of the bronchi.

Top Publications

  1. ncbi Chronic suppurative lung disease and bronchiectasis in children and adults in Australia and New Zealand
    Anne B Chang
    Royal Children s Hospital and Queensland Children s Medical Research Institute, Brisbane, QLD, Australia
    Med J Aust 193:356-65. 2010
  2. ncbi Azithromycin for prevention of exacerbations in non-cystic fibrosis bronchiectasis (EMBRACE): a randomised, double-blind, placebo-controlled trial
    Conroy Wong
    Department of Respiratory Medicine, Middlemore Hospital, Counties Manukau District Health Board, Auckland, New Zealand
    Lancet 380:660-7. 2012
  3. ncbi Factors associated with bronchiectasis in patients with COPD
    Miguel Angel Martínez-García
    Unidad de Neumología, Hospital General de Requena, Paraje Casa Blanca s n, 43230 Valencia, Spain
    Chest 140:1130-7. 2011
  4. pmc Trends in bronchiectasis among medicare beneficiaries in the United States, 2000 to 2007
    Amy E Seitz
    Epidemiology Unit, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Chest 142:432-9. 2012
  5. ncbi Research priorities in bronchiectasis
    Anthony De Soyza
    Institute of Cellular Medicine, Newcastle University and Freeman Hospital Adult Bronchiectasis Service, Newcastle upon Tyne, Tyne and Wear, UK
    Thorax 68:695-6. 2013
  6. ncbi Effect of long-term, low-dose erythromycin on pulmonary exacerbations among patients with non-cystic fibrosis bronchiectasis: the BLESS randomized controlled trial
    David J Serisier
    Department of Respiratory Medicine, Level 9, Mater Adult Hospital, Raymond Terr, South Brisbane, Queensland 4101, Australia
    JAMA 309:1260-7. 2013
  7. ncbi Clinical measures of disease in adult non-CF bronchiectasis correlate with airway microbiota composition
    Geraint B Rogers
    Molecular Microbiology Research Laboratory, Institute of Pharmaceutical Science, King s College London, London, UK
    Thorax 68:731-7. 2013
  8. ncbi Chronic colonization by Pseudomonas aeruginosa of patients with obstructive lung diseases: cystic fibrosis, bronchiectasis, and chronic obstructive pulmonary disease
    Andrea D Valderrey
    Departamento de Microbiologia II, Facultad de Farmacia, Universidad Complutense, Madrid, Spain
    Diagn Microbiol Infect Dis 68:20-7. 2010
  9. ncbi British Thoracic Society guideline for non-CF bronchiectasis
    M C Pasteur
    Norfolk and Norwich University Hospital, Colney Lane, Norwich NR4 7UY, UK
    Thorax 65:i1-58. 2010
  10. ncbi Airway microbiology and host defences in paediatric non-CF bronchiectasis
    Keith Grimwood
    Queensland Paediatric Infectious Diseases Laboratory, Queensland Children s Medical Research Institute, The University of Queensland, Royal Children s Hospital, Brisbane, Queensland, Australia
    Paediatr Respir Rev 12:111-8. 2011

Research Grants

  1. Iowa Phase II Clinical Trials of Novel Therapies for Lung Diseases (U01
    Lakshmi Durairaj; Fiscal Year: 2012
  2. Polymicrobial interactions in the lung.
    JENNIFER MELINDA BOMBERGER; Fiscal Year: 2010
  3. Polymicrobial Interactions in the Lung
    JENNIFER MELINDA BOMBERGER; Fiscal Year: 2013
  4. HORMONAL INFLUENCES ON AIRWAY DISEASE
    Raksha Jain; Fiscal Year: 2013
  5. In vitro and in vivo efficacy of liposomal ciprofloxacin formulations against Myc
    Igor Gonda; Fiscal Year: 2013
  6. Genetic Disorder of Mucocilary Clearance
    Michael R Knowles; Fiscal Year: 2013
  7. Pilot Studies of Gene Therapy for Primary Ciliary Dyskinesia
    Lawrence E Ostrowski; Fiscal Year: 2010
  8. Real-Time Reagent-Free Noninvasive Diagnosis of Tuberculosis
    Payam Nahid; Fiscal Year: 2013
  9. Early-life arsenic exposure and adult mortality in Region II, Chile
    Allan H Smith; Fiscal Year: 2013
  10. Viral Pathogenesis of Early Cystic Fibrosis Lung Disease
    SARATH CHANDRA RANGANATHAN; Fiscal Year: 2013

Detail Information

Publications306 found, 100 shown here

  1. ncbi Chronic suppurative lung disease and bronchiectasis in children and adults in Australia and New Zealand
    Anne B Chang
    Royal Children s Hospital and Queensland Children s Medical Research Institute, Brisbane, QLD, Australia
    Med J Aust 193:356-65. 2010
    Consensus recommendations for managing chronic suppurative lung disease (CSLD) and bronchiectasis, based on systematic reviews, were developed for Australian and New Zealand children and adults during a multidisciplinary workshop...
  2. ncbi Azithromycin for prevention of exacerbations in non-cystic fibrosis bronchiectasis (EMBRACE): a randomised, double-blind, placebo-controlled trial
    Conroy Wong
    Department of Respiratory Medicine, Middlemore Hospital, Counties Manukau District Health Board, Auckland, New Zealand
    Lancet 380:660-7. 2012
    ..We tested the hypothesis that azithromycin would decrease the frequency of exacerbations, increase lung function, and improve health-related quality of life in patients with non-cystic fibrosis bronchiectasis.
  3. ncbi Factors associated with bronchiectasis in patients with COPD
    Miguel Angel Martínez-García
    Unidad de Neumología, Hospital General de Requena, Paraje Casa Blanca s n, 43230 Valencia, Spain
    Chest 140:1130-7. 2011
    Previous studies have shown a high prevalence of bronchiectasis in patients with moderate to severe COPD. However, the factors associated with bronchiectasis remain unknown in these patients...
  4. pmc Trends in bronchiectasis among medicare beneficiaries in the United States, 2000 to 2007
    Amy E Seitz
    Epidemiology Unit, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Chest 142:432-9. 2012
    b>Bronchiectasis is a potentially serious condition characterized by permanent and abnormal widening of the airways, the prevalence of which is not well described...
  5. ncbi Research priorities in bronchiectasis
    Anthony De Soyza
    Institute of Cellular Medicine, Newcastle University and Freeman Hospital Adult Bronchiectasis Service, Newcastle upon Tyne, Tyne and Wear, UK
    Thorax 68:695-6. 2013
    Taking a network approach, we have identified research priorities in non-cystic fibrosis bronchiectasis. We discuss these in the context of increasing recognition of bronchiectasis and increasing mortality rates.
  6. ncbi Effect of long-term, low-dose erythromycin on pulmonary exacerbations among patients with non-cystic fibrosis bronchiectasis: the BLESS randomized controlled trial
    David J Serisier
    Department of Respiratory Medicine, Level 9, Mater Adult Hospital, Raymond Terr, South Brisbane, Queensland 4101, Australia
    JAMA 309:1260-7. 2013
    Macrolide antibiotics such as erythromycin may improve clinical outcomes in non-cystic fibrosis (CF) bronchiectasis, although associated risks of macrolide resistance are poorly defined.
  7. ncbi Clinical measures of disease in adult non-CF bronchiectasis correlate with airway microbiota composition
    Geraint B Rogers
    Molecular Microbiology Research Laboratory, Institute of Pharmaceutical Science, King s College London, London, UK
    Thorax 68:731-7. 2013
    Despite the potentially important roles for infection in adult non-cystic fibrosis (CF) bronchiectasis disease progression, the bacterial species present in the lower airways of these patients is poorly characterised.
  8. ncbi Chronic colonization by Pseudomonas aeruginosa of patients with obstructive lung diseases: cystic fibrosis, bronchiectasis, and chronic obstructive pulmonary disease
    Andrea D Valderrey
    Departamento de Microbiologia II, Facultad de Farmacia, Universidad Complutense, Madrid, Spain
    Diagn Microbiol Infect Dis 68:20-7. 2010
    Pseudomonas aeruginosa is isolated in sputum cultures from cystic fibrosis (CF) patients and adults with bronchiectasis (BS) and chronic obstructive pulmonary disease, but it is not well known if the characteristics of colonization in ..
  9. ncbi British Thoracic Society guideline for non-CF bronchiectasis
    M C Pasteur
    Norfolk and Norwich University Hospital, Colney Lane, Norwich NR4 7UY, UK
    Thorax 65:i1-58. 2010
    The diagnosis, investigation and particularly management of bronchiectasis has been largely empirical and the subject of relatively few controlled clinical trials...
  10. ncbi Airway microbiology and host defences in paediatric non-CF bronchiectasis
    Keith Grimwood
    Queensland Paediatric Infectious Diseases Laboratory, Queensland Children s Medical Research Institute, The University of Queensland, Royal Children s Hospital, Brisbane, Queensland, Australia
    Paediatr Respir Rev 12:111-8. 2011
    b>Bronchiectasis in children without cystic fibrosis is most common in socioeconomically disadvantaged communities. Recurrent pneumonia in early childhood and defective pulmonary defences are important risk factors...
  11. ncbi An investigation into causative factors in patients with bronchiectasis
    M C Pasteur
    Lung Defence Unit, Department of Immunology, Papworth Hospital, Cambridge, United Kingdom
    Am J Respir Crit Care Med 162:1277-84. 2000
    b>Bronchiectasis is a pathologic description of lung damage characterized by inflamed and dilated thick-walled bronchi. These findings may result from a number of possible causes and these may influence treatment and prognosis...
  12. ncbi Factors associated with lung function decline in adult patients with stable non-cystic fibrosis bronchiectasis
    Miguel Angel Martínez-García
    Unidad de Neumología, Service of Internal Medicine, Hospital General de Requena, Paraje Casa Blanca s n, 43230, Valencia, Spain
    Chest 132:1565-72. 2007
    b>Bronchiectasis remains a major public health problem, but factors influencing its natural history are not well characterized...
  13. pmc Innate immune activation in neutrophilic asthma and bronchiectasis
    Jodie L Simpson
    Department of Respiratory and Sleep Medicine, School of Medicine and Public Health, Hunter Medical Research Institute, The University of Newcastle, Newcastle, Australia
    Thorax 62:211-8. 2007
    ..The inflammatory response in asthma is heterogeneous...
  14. ncbi Chronic wet cough: Protracted bronchitis, chronic suppurative lung disease and bronchiectasis
    A B Chang
    Child Health Division, Menzies School of Health Research, Charles Darwin University, Darwin, Australia
    Pediatr Pulmonol 43:519-31. 2008
    ..This is probably related (at least in part) to the (a) reduction in non-CF bronchiectasis in affluent countries and, (b) intense focus on asthma...
  15. ncbi Effect of azithromycin maintenance treatment on infectious exacerbations among patients with non-cystic fibrosis bronchiectasis: the BAT randomized controlled trial
    Josje Altenburg
    Department of Pulmonary Diseases, Medical Centre Alkmaar, Wilhelminalaan 12, 1812 JD Alkmaar, The Netherlands
    JAMA 309:1251-9. 2013
    Macrolide antibiotics have been shown beneficial in cystic fibrosis (CF) and diffuse panbronchiolitis, and earlier findings also suggest a benefit in non-CF bronchiectasis.
  16. ncbi Prognostic value of bronchiectasis in patients with moderate-to-severe chronic obstructive pulmonary disease
    Miguel Angel Martínez-García
    Pneumology Service, Polytechnic and University La Fe Hospital, Valencia, Spain
    Am J Respir Crit Care Med 187:823-31. 2013
    The prevalence of bronchiectasis is high in patients with moderate-to-severe chronic obstructive pulmonary disease (COPD) and it has been associated with exacerbations and bacterial colonization...
  17. pmc Lung microbiota and bacterial abundance in patients with bronchiectasis when clinically stable and during exacerbation
    Michael M Tunney
    Cystic Fibrosis and Airways Microbiology Research Group, School of Medicine, Dentistry, and Biomedical Sciences, Queen s University Belfast, Belfast, United Kingdom
    Am J Respir Crit Care Med 187:1118-26. 2013
    ..Characterization of bacterial populations in infectious respiratory diseases will provide improved understanding of the relationship between the lung microbiota, disease pathogenesis, and treatment outcomes...
  18. ncbi Lung clearance index is a repeatable and sensitive indicator of radiological changes in bronchiectasis
    Stephen A Rowan
    1 Centre for Infection and Immunity, Queen s University of Belfast, Belfast, United Kingdom
    Am J Respir Crit Care Med 189:586-92. 2014
    In bronchiectasis there is a need for improved markers of lung function to determine disease severity and response to therapy.
  19. ncbi Depression and anxiety symptoms in bronchiectasis: associations with health-related quality of life
    Casilda Olveira
    Pneumology Service, Carlos Haya University Hospital, Avenida Carlos Haya, 29010, Malaga, Spain
    Qual Life Res 22:597-605. 2013
    b>Bronchiectasis causes pulmonary infections and loss of lung function, resulting in chronic respiratory symptoms and worsening health-related quality of life...
  20. ncbi Trends in bronchiectasis mortality in England and Wales
    Helen J Roberts
    Nottingham University Hospitals NHS Trust, United Kingdom
    Respir Med 104:981-5. 2010
    To provide information on the burden of bronchiectasis in England and Wales, we have examined trends in mortality using death certificate data available from the Office of National Statistics.
  21. ncbi Non-cystic fibrosis bronchiectasis: diagnosis and management in 21st century
    Pieter Goeminne
    Laboratory of Pneumology, University Hospital Gasthuisberg, Katholieke Universiteit Leuven, Belgium
    Postgrad Med J 86:493-501. 2010
    b>Bronchiectasis is permanently dilated airways caused by chronic bronchial inflammation secondary to inappropriate clearance of various micro-organisms and recurrent infections in the airways...
  22. ncbi Bronchiectasis, exacerbation indices, and inflammation in chronic obstructive pulmonary disease
    Irem S Patel
    Academic Unit of Respiratory Medicine, Dominion House, St Bartholomew s Hospital, West Smithfield, London EC1A 7BE, UK
    Am J Respir Crit Care Med 170:400-7. 2004
    ..5 [33.5] smoking pack-years) underwent HRCT scans of the chest to quantify the presence and extent of bronchiectasis or emphysema. Exacerbation indices were determined from diary cards over 2 years...
  23. ncbi Bronchiectasis
    Alan F Barker
    Pulmonary and Critical Care Division, Department of Medicine, Oregon Health and Science University, Portland 97201, USA
    N Engl J Med 346:1383-93. 2002
  24. ncbi Bronchiectasis in persons with skin lesions resulting from arsenic in drinking water
    D N Guha Mazumder
    Institute of Post Graduate Medical Education and Research, Kolkata, India
    Epidemiology 16:760-5. 2005
    ..Less is known about nonmalignant pulmonary disease after exposure to arsenic in drinking water...
  25. ncbi Exacerbations in cystic fibrosis: 4--Non-cystic fibrosis bronchiectasis
    A B Chang
    Department of Respiratory Medicine, Royal Children s Hospital, Herston Road, Brisbane, Queensland 4029, Australia
    Thorax 63:269-76. 2008
    b>Bronchiectasis unrelated to cystic fibrosis (CF) is increasingly recognised as an important and major primary respiratory disease in developing countries...
  26. pmc Qualitative analysis of high-resolution CT scans in severe asthma
    Sumit Gupta
    Institute for Lung Health, University of Leicester, Leicester, UK
    Chest 136:1521-8. 2009
    ..We sought to describe the HRCT scan abnormalities of a large severe asthma cohort and to determine the utility of clinical features to direct the use of HRCT scanning in this group of patients...
  27. ncbi Lower airway microbiology and cellularity in children with newly diagnosed non-CF bronchiectasis
    Nitin Kapur
    Department of Respiratory Medicine, Royal Children s Hospital, Brisbane, Queensland, Australia
    Pediatr Pulmonol 47:300-7. 2012
    Infection and inflammation are important in the pathogenesis of bronchiectasis. However, there are few published data describing the lower airway microbiology and cellularity in children.
  28. ncbi Nontuberculous mycobacteria in bronchiectasis: Prevalence and patient characteristics
    S J Fowler
    Lung Defence Clinic, Cambridge, UK
    Eur Respir J 28:1204-10. 2006
    ..associations of nontuberculous mycobacteria (NTM) in a well-characterised cohort of patients with adult-onset bronchiectasis. The sputum of all patients attending a tertiary referral bronchiectasis clinic between April 2002 and August ..
  29. pmc Bronchiectasis-associated hospitalizations in Germany, 2005-2011: a population-based study of disease burden and trends
    Felix C Ringshausen
    Department of Respiratory Medicine, Hannover Medical School, Hannover, Germany
    PLoS ONE 8:e71109. 2013
    Representative population-based data on the epidemiology of bronchiectasis in Europe are limited...
  30. ncbi Primary care summary of the British Thoracic Society Guideline on the management of non-cystic fibrosis bronchiectasis
    Adam T Hill
    Department of Respiratory Medicine, Royal Infirmary and University of Edinburgh, Scotland, UK
    Prim Care Respir J 20:135-40. 2011
    ..Thoracic Society (BTS) has recently published a guideline for the management of non-cystic fibrosis (non-CF) bronchiectasis in children and adults. This paper summarises the key recommendations applicable to the primary care setting...
  31. ncbi Short- and long-term antibiotic treatment reduces airway and systemic inflammation in non-cystic fibrosis bronchiectasis
    James D Chalmers
    Royal Infirmary of Edinburgh, Department of Respiratory Medicine, Edinburgh, United Kingdom
    Am J Respir Crit Care Med 186:657-65. 2012
    The vicious cycle hypothesis of bronchiectasis argues that bacterial colonization leads to airway inflammation and progressive lung damage...
  32. ncbi Mortality in bronchiectasis: a long-term study assessing the factors influencing survival
    M R Loebinger
    Host Defence Unit, Royal Brompton Hospital, London, UK
    Eur Respir J 34:843-9. 2009
    There is little literature about the mortality associated with bronchiectasis. The aim of the present study was to investigate factors affecting mortality in patients with bronchiectasis...
  33. ncbi Elevated peripheral airway nitric oxide in bronchiectasis reflects disease severity
    A Shoemark
    Host Defence Unit, Royal Brompton Hospital, Sydney Street, London SW3 6NP, UK
    Respir Med 105:885-91. 2011
    b>Bronchiectasis is characterised by neutrophilic bronchial inflammation and patients are prone to recurrent or chronic bacterial airway infections...
  34. ncbi A randomized controlled trial of nebulized gentamicin in non-cystic fibrosis bronchiectasis
    Maeve P Murray
    Department of Respiratory Medicine, Royal Infirmary of Edinburgh, Edinburgh, UK
    Am J Respir Crit Care Med 183:491-9. 2011
    b>Bronchiectasis is a chronic debilitating disease with few evidence-based long-term treatments.
  35. ncbi Exacerbations in noncystic fibrosis bronchiectasis: Clinical features and investigations
    Nitin Kapur
    Queensland Children s Respiratory Centre, Royal Children s Hospital, Australia
    Respir Med 103:1681-7. 2009
    Children with bronchiectasis have recurrent acute pulmonary exacerbations and many of these exacerbations require hospital admission when oral therapies fail...
  36. ncbi Aerosolized antibiotics for non-cystic fibrosis bronchiectasis
    Bruce K Rubin
    Department of Pediatrics, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1081, USA
    J Aerosol Med Pulm Drug Deliv 21:71-6. 2008
    ..b>Bronchiectasis is caused by reoccurring or continuous presence of bacteria in association with airway obstruction...
  37. ncbi Defining pulmonary exacerbation in children with non-cystic fibrosis bronchiectasis
    Nitin Kapur
    Department of Respiratory Medicine, Royal Children s Hospital, Brisbane, Queensland, Australia
    Pediatr Pulmonol 47:68-75. 2012
    Exacerbations in non-cystic fibrosis (CF) bronchiectasis are associated with worsening lung functions and quality of life. A standardized definition of exacerbation could improve clinical care and research.
  38. ncbi Diagnosing and preventing chronic suppurative lung disease (CSLD) and bronchiectasis
    A B Chang
    Child Health Division, Menzies School of Health Research, Charles Darwin University, Darwin, NT Queensland Children s Respiratory Centre and Queensland Children s Medical Research Institute, Royal Children s Hospital, Brisbane, Australia
    Paediatr Respir Rev 12:97-103. 2011
    Current diagnostic labelling of childhood bronchiectasis by radiology has substantial limitations...
  39. ncbi Bronchiectasis is associated with human T-lymphotropic virus 1 infection in an Indigenous Australian population
    Lloyd Einsiedel
    Department of Medicine, Alice Springs Hospital, Alice Springs, Australia
    Clin Infect Dis 54:43-50. 2012
    Recent studies suggest that infection with human T-lymphotropic virus 1 (HTLV-1) might be associated with bronchiectasis among Indigenous Australians...
  40. ncbi Management of bronchiectasis and chronic suppurative lung disease in indigenous children and adults from rural and remote Australian communities
    Anne B Chang
    Department of Respiratory Medicine, Royal Children s Hospital, Brisbane, QLD
    Med J Aust 189:386-93. 2008
    1) Consensus recommendations for managing bronchiectasis in Indigenous children and adults living in rural and remote regions were developed during a multidisciplinary workshop and were based on available systematic reviews...
  41. ncbi Assessing response to treatment of exacerbations of bronchiectasis in adults
    M P Murray
    Dept of Respiratory Medicine, 51 Little France Crescent, Old Dalkeith Road, Edinburgh, EH16 4SA, UK
    Eur Respir J 33:312-8. 2009
    ..of intravenous antibiotic therapy on clinical and laboratory end-points in exacerbations of noncystic fibrosis bronchiectasis and to determine whether the outcomes were influenced by the pathogenic organism isolated...
  42. ncbi Longitudinal growth and lung function in pediatric non-cystic fibrosis bronchiectasis: what influences lung function stability?
    Nitin Kapur
    Queensland Children s Respiratory Centre and Queensland Children s Medical Research Institute, Department of Respiratory Medicine, Royal Children s Hospital, Herston, QLD 4029, Australia
    Chest 138:158-64. 2010
    Longitudinal FEV(1) data in children with non-cystic fibrosis (non-CF) bronchiectasis (BE) are contradictory, and there are no multifactor data on the evolution of lung function and growth in this group...
  43. ncbi Bronchiectasis secondary to primary immunodeficiency in children: longitudinal changes in structure and function
    Katerina Haidopoulou
    Fourth Department of Pediatrics, School of Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece
    Pediatr Pulmonol 44:669-75. 2009
    Primary immunodeficiency is a common cause of bronchiectasis in children. The term bronchiectasis suggests an irreversible process; however, disease progression following treatment is controversial...
  44. ncbi Evaluation of nebulised hypertonic saline (7%) as an adjunct to physiotherapy in patients with stable bronchiectasis
    F Kellett
    North West Lung Center, Wythenshawe Hospital, South Moor Road, Manchester M23 9LT, UK
    Respir Med 99:27-31. 2005
    Sputum clearance is of prime importance in the management of patients with bronchiectasis. While nebulised normal isotonic saline (0...
  45. ncbi Update on non-cystic fibrosis bronchiectasis
    Diana Bilton
    Royal Brompton Hospital, Sydney Street, London, UK
    Curr Opin Pulm Med 14:595-9. 2008
    ..awareness in both adult and paediatric respiratory clinics regarding the importance of non-cystic fibrosis bronchiectasis. There has been debate regarding the requirement for investigations to establish an underlying cause of ..
  46. ncbi The burden of disease in pediatric non-cystic fibrosis bronchiectasis
    Nitin Kapur
    Department of Respiratory Medicine, Queensland Children s Medical Research Institute, Royal Children s Hospital, Herston, QLD 4029, Australia
    Chest 141:1018-24. 2012
    The burden of disease in children with non-cystic fibrosis (non-CF) bronchiectasis is unknown...
  47. ncbi Quality of life and inflammation in exacerbations of bronchiectasis
    J M Courtney
    Respiratory Research Centre, Belfast City Hospital, Belfast, Northern Ireland
    Chron Respir Dis 5:161-8. 2008
    Patients with bronchiectasis often have impaired quality of life (QoL), which deteriorates with exacerbations...
  48. ncbi Long-term, low-dose erythromycin in bronchiectasis subjects with frequent infective exacerbations
    D J Serisier
    Dept of Respiratory Medicine, Lvl 9, Mater Adult Hospital, Raymond Tce, South Brisbane, QLD 4101, Australia
    Respir Med 105:946-9. 2011
    Macrolide antibiotics are increasingly prescribed for subjects with non-cystic fibrosis (CF) bronchiectasis, an empiric extension of their proven efficacy in CF...
  49. pmc The need to redefine non-cystic fibrosis bronchiectasis in childhood
    K M Eastham
    Sir James Spence Institute of Child Health, Royal Victoria Infirmary, Newcastle upon Tyne NE1 4LP, UK
    Thorax 59:324-7. 2004
    Non-cystic fibrosis (CF) bronchiectasis has previously been reported to be rare and progressive in children living in western societies.
  50. ncbi HLA-C and killer cell immunoglobulin-like receptor genes in idiopathic bronchiectasis
    Rosemary J Boyton
    Lung Immunology Group, Department of Biological Sciences National Heart and Lung Institute, Sir Alexander Fleming Building, South Kensington Campus, London SW7 2AZ, UK
    Am J Respir Crit Care Med 173:327-33. 2006
    In idiopathic bronchiectasis, lung inflammation and chronic bacterial infection lead to progressive lung damage...
  51. pmc Increased mortality from lung cancer and bronchiectasis in young adults after exposure to arsenic in utero and in early childhood
    Allan H Smith
    Arsenic Health Effects Research Program, University of California, Berkeley, California 94720 7360, USA
    Environ Health Perspect 114:1293-6. 2006
    ..0 [95% confidence interval (CI), 5.4-8.9; p<0.001] and the SMR for bronchiectasis was 12.4 (95% CI, 3.3-31.7; p<0.001)...
  52. ncbi Validation of the Leicester Cough Questionnaire in non-cystic fibrosis bronchiectasis
    M P Murray
    Royal Infirmary of Edinburgh, Department of Respiratory Medicine, 51 Little France Crescent, Old Dalkeith Road, Edinburgh, EH16 4SA, UK
    Eur Respir J 34:125-31. 2009
    Health-related quality of life is a potentially important marker for evaluating existing and new therapies in bronchiectasis. The Leicester Cough Questionnaire (LCQ) is a symptom specific questionnaire designed to assess the impact of ..
  53. ncbi Bronchiectasis in infants and preschool children diagnosed with cystic fibrosis after newborn screening
    Stephen M Stick
    Department of Respiratory Medicine, Princess Margaret Hospital for Children, School of Paediatrics and Child Health, University of Western Australia, Melbourne, Australia
    J Pediatr 155:623-8.e1. 2009
    To determine the prevalence of bronchiectasis in young children with cystic fibrosis (CF) diagnosed after newborn screening (NBS) and the relationship of bronchiectasis to pulmonary inflammation and infection.
  54. pmc Trends and burden of bronchiectasis-associated hospitalizations in the United States, 1993-2006
    Amy E Seitz
    National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Chest 138:944-9. 2010
    Current data on bronchiectasis prevalence, trends, and risk factors are lacking; such data are needed to estimate the burden of disease and for improved medical care and public health resource allocation...
  55. ncbi Microbiologic follow-up study in adult bronchiectasis
    Paul T King
    Department of Respiratory and Sleep Medicine, Monash Medical Centre, Clayton, Melbourne 3168, Australia
    Respir Med 101:1633-8. 2007
    There is minimal published longitudinal data about pathogenic microorganisms in adults with bronchiectasis. Therefore a study was undertaken to assess the microbiologic profile over time in bronchiectasis...
  56. ncbi Aspergillus sensitization is associated with airflow limitation and bronchiectasis in severe asthma
    D Menzies
    North West Lung Centre, University Hospital of South Manchester, Wythenshawe Hospital, Manchester, UK
    Allergy 66:679-85. 2011
    Abnormalities, including bronchiectasis, that are detectable on high-resolution computed tomography (HRCT) have been associated with severe asthma...
  57. pmc New Zealand national incidence of bronchiectasis "too high" for a developed country
    J Twiss
    Starship Childrens Hospital, Auckland District Health Board, Auckland, New Z
    Arch Dis Child 90:737-40. 2005
    To prospectively estimate the incidence of bronchiectasis among New Zealand (NZ) children, to consider aetiology and severity, and to evaluate regional and ethnic variation.
  58. ncbi Bronchiectasis in Alaska Native children: causes and clinical courses
    R Singleton
    Alaska Native Tribal Health Consortium, Anchorage, Alaska, USA
    Pediatr Pulmonol 29:182-7. 2000
    Although bronchiectasis has become a rare condition in U.S. children, it is still commonly diagnosed in Alaska Native children in the Yukon Kuskokwim Delta...
  59. ncbi Aetiology in adult patients with bronchiectasis
    A Shoemark
    Host Defence Unit, Royal Brompton Hospital, Sydney Street, London SW3 6NP, UK
    Respir Med 101:1163-70. 2007
    b>Bronchiectasis has a number of causes. Their prevalence is not well documented...
  60. ncbi Outcome in adult bronchiectasis
    Paul T King
    Department of Respiratory Medicine, Monash Medical Centre, 246 Clayton Rd, Clayton, Melbourne, Victoria, Australia
    COPD 2:27-34. 2005
    The outcome in adult bronchiectasis has not been well described; in particular there has been a lack of long-term prospective studies...
  61. ncbi Genetic causes of bronchiectasis: primary ciliary dyskinesia
    Hilda N Morillas
    CF Pulmonary Research and Treatment Center, University of North Carolina, Chapel Hill, NC 27599 7248, USA
    Respiration 74:252-63. 2007
    ..Clinical manifestations include respiratory distress in term neonates, recurrent otosinopulmonary infections, bronchiectasis, situs inversus and/or heterotaxy, and male infertility...
  62. ncbi Bronchiectasis
    Anne E O'Donnell
    Georgetown University Medical Center, Washington DC, USA
    Chest 134:815-23. 2008
    b>Bronchiectasis, which was once thought to be an orphan disease, is now being recognized with increasing frequency around the world...
  63. ncbi Clinical challenges in managing bronchiectasis
    Kenneth W Tsang
    The University of Hong Kong, 1202 Central Building, 1 3 Pedder Street Central, Hong Kong, China
    Respirology 14:637-50. 2009
    b>Bronchiectasis is a common disease in the Asia-Pacific and affected patients suffer from chronic sputum production and recurrent exacerbations. Bronchiectasis is largely idiopathic although there is diverse aetiology...
  64. ncbi Bilateral bronchiectasis and bronchiolitis at thin-section CT: diagnostic implications in nontuberculous mycobacterial pulmonary infection
    Won Jung Koh
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Ilwon Dong, Kangnam Ku, Seoul 135 710, Korea
    Radiology 235:282-8. 2005
    To determine frequency of nontuberculous mycobacterial (NTM) pulmonary infection in patients with bilateral bronchiectasis and bronchiolitis at chest computed tomography (CT) and whether CT findings are indicative of Mycobacterium avium-..
  65. pmc Bacterial colonisation in patients with bronchiectasis: microbiological pattern and risk factors
    J Angrill
    Unitat de Vigilància Intensiva Respiratòria, Servei de Pneumologia, Institut Clinic de Pneumologia i Cirurgia Toracica, Universitat de Barcelona, Villarroel 170, E 08036 Barcelona, Spain
    Thorax 57:15-9. 2002
    A study was undertaken to investigate the incidence, diagnostic yield of non-invasive and bronchoscopic techniques, and risk factors of airway colonisation in patients with bronchiectasis in a stable clinical situation.
  66. ncbi Bronchiectasis: not an orphan disease in the East
    K W Tsang
    Department of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong SAR, China
    Int J Tuberc Lung Dis 8:691-702. 2004
    b>Bronchiectasis is a common disease in the developing world. While the aetiology of bronchiectasis is diverse, many patients suffer from idiopathic disease...
  67. ncbi Bronchial inflammation and colonization in patients with clinically stable bronchiectasis
    J Angrill
    Servei de Pneumologia, , Spain
    Am J Respir Crit Care Med 164:1628-32. 2001
    To evaluate the bronchial inflammatory response and its relationship to bacterial colonization in bronchiectasis, we performed a bronchoalveolar lavage (BAL) in 49 patients in stable clinical condition and in nine control subjects...
  68. ncbi The effect of Pseudomonas aeruginosa on pulmonary function in patients with bronchiectasis
    G Davies
    Host Defence Unit, Royal Brompton Hospital, Sydney Street, London SW3 6NP, UK
    Eur Respir J 28:974-9. 2006
    b>Bronchiectasis patients are susceptible to infection with Pseudomonas aeruginosa. Isolation is associated with increased severity of disease, greater airflow obstruction and poorer quality of life. It is not known whether infection by P...
  69. ncbi Adrenal suppression in bronchiectasis and the impact of inhaled corticosteroids
    J Holme
    Dept of Endocrinology, Division of Medical Sciences, University of Birmingham, Birmingham, UK
    Eur Respir J 32:1047-52. 2008
    The present study identified three patients with bronchiectasis receiving inhaled corticosteroids (ICSs) who had symptomatic adrenal suppression secondary to ICS. The prevalence of adrenal suppression is unknown in bronchiectasis...
  70. ncbi Pulmonary nocardiosis in a patient with chronic obstructive pulmonary disease and bronchiectasis
    Miguel Abidon Aidê
    Universidade Federal Fluminense, Niteroi, RJ, Brasil
    J Bras Pneumol 34:985-8. 2008
    We report the case of a patient with chronic obstructive pulmonary disease and bronchiectasis, chronically using corticosteroids, who acquired pulmonary nocardiosis, which presented as multiple cavitated nodules...
  71. ncbi Respiratory bacterial pathogens in the nasopharynx and lower airways of Australian indigenous children with bronchiectasis
    Kim M Hare
    Child Health Division, Menzies School of Health Research, Charles Darwin University, Darwin, Northern Territory, Australia
    J Pediatr 157:1001-5. 2010
    To test the hypothesis that bacterial density, strain diversity, and concordance of pathogens between upper and lower airways are higher in children with bronchiectasis than in those with non-bronchiectatic conditions.
  72. ncbi Tuberculosis, bronchiectasis and chronic airflow obstruction
    Toni S Jordan
    TB Unit, Liverpool Heart and Chest Hospital, Thomas Drive, Liverpool, UK
    Respirology 15:623-8. 2010
    Both tuberculosis and bronchiectasis carry a significant burden worldwide in terms of morbidity and mortality, as well as financial, especially in the developing world...
  73. ncbi Fatigue in bronchiectasis
    K L M Hester
    Freeman Hospital, Freeman Road, High Heaton, Newcastle upon Tyne, NE7 7DN, UK
    QJM 105:235-40. 2012
    Fatigue is a complex, disabling symptom in non-CF bronchiectasis (nCF-Br). Fatigue can be formally measured using the validated fatigue impact scale (FIS)...
  74. pmc Antibiotics for bronchiectasis exacerbations in children: rationale and study protocol for a randomised placebo-controlled trial
    Anne B Chang
    Child Health Division, Menzies School of Health Research, Charles Darwin University, Darwin, NT, Australia
    Trials 13:156. 2012
    Despite bronchiectasis being increasingly recognised as an important cause of chronic respiratory morbidity in both indigenous and non-indigenous settings globally, high quality evidence to inform management is scarce...
  75. ncbi Vitamin-D deficiency is associated with chronic bacterial colonisation and disease severity in bronchiectasis
    James D Chalmers
    The University of Edinburgh MRC Centre for Research Inflammation, The Queen s Medical Research Institute, Edinburgh, UK
    Thorax 68:39-47. 2013
    Vitamin-D deficiency has been linked to an increased risk of respiratory infections. The objective of this study was to determine the frequency and clinical importance of vitamin-D deficiency in patients with bronchiectasis.
  76. ncbi Pathogenesis of bronchiectasis
    Paul King
    Department of Respiratory and Sleep Medicine and Monash University Department of Medicine, Monash Medical Centre, Melbourne, Australia
    Paediatr Respir Rev 12:104-10. 2011
    Non-cystic fibrosis bronchiectasis is a heterogeneous condition and its pathogenesis is still not well defined...
  77. ncbi Mechanisms of immune dysfunction and bacterial persistence in non-cystic fibrosis bronchiectasis
    James D Chalmers
    Tayside Respiratory Research Group, University of Dundee, Ninewells Hospital, Dundee, United Kingdom
    Mol Immunol 55:27-34. 2013
    b>Bronchiectasis is a chronic inflammatory lung disease. The underlying cause is not identified in the majority of patients, but bronchiectasis is associated with a number of severe infections, immunodeficiencies and autoimmune disorders...
  78. ncbi Predictors of mortality in hospitalized patients with acute exacerbation of bronchiectasis
    James D Finklea
    Department of Pulmonary, Allergy, and Critical Care Medicine, Emory University Hospital, Atlanta, Georgia, United States
    Respir Med 104:816-21. 2010
    In-hospital and long term outcomes of patients admitted to the hospital for acute exacerbation of bronchiectasis (AEB) has been evaluated in only a limited fashion. The resulting debilitation after an AEB can increase mortality...
  79. pmc Changes in B cell immunophenotype in common variable immunodeficiency: cause or effect - is bronchiectasis indicative of undiagnosed immunodeficiency?
    P Bright
    Immunology Department, Barts Health NHS Trust, London, UK
    Clin Exp Immunol 171:195-200. 2013
    ..compares the EUROclass B cell immunophenotype of CVID patients (n = 30) with suitable disease controls with bronchiectasis (n = 11), granulomatous disease (Crohn's disease) (n = 9) and neurological patients on immunoglobulin ..
  80. ncbi Sputum elastase in steady-state bronchiectasis
    K W Tsang
    University Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong SAR, China
    Chest 117:420-6. 2000
    To study the correlations between sputum elastase output with clinical and sputum inflammatory and microbial factors in steady-state bronchiectasis.
  81. ncbi Risk factors for bronchiectasis in children with cystic fibrosis
    Peter D Sly
    Queensland Children s Medical Research Institute, Brisbane, Australia
    N Engl J Med 368:1963-70. 2013
    b>Bronchiectasis develops early in the course of cystic fibrosis, being detectable in infants as young as 10 weeks of age, and is persistent and progressive...
  82. pmc Inhaled colistin in patients with bronchiectasis and chronic Pseudomonas aeruginosa infection
    Charles S Haworth
    1 Cambridge Centre for Lung Infection and
    Am J Respir Crit Care Med 189:975-82. 2014
    Chronic infection with Pseudomonas aeruginosa is associated with an increased exacerbation frequency, a more rapid decline in lung function, and increased mortality in patients with bronchiectasis.
  83. ncbi HIV-related bronchiectasis in children: an emerging spectre in high tuberculosis burden areas
    R Masekela
    Department of Paediatrics and Child Health, Division of Paediatric Pulmonology, Steve Biko Academic Hospital, University of Pretoria, Pretoria, South Africa
    Int J Tuberc Lung Dis 16:114-9. 2012
    Human immunodeficiency virus (HIV) infected children have an eleven-fold risk of acute lower respiratory tract infection. This places HIV-infected children at risk of airway destruction and bronchiectasis.
  84. ncbi Specific antibody response against the 23-valent pneumococcal vaccine in patients with alpha(1)-antitrypsin deficiency with and without bronchiectasis
    M Miravitlles
    Department of Pneumology, Hospital General Vall d Hebron, Barcelona, Spain
    Chest 116:946-52. 1999
    ..To assess the specific antibody response against polyvalent pneumococcal vaccine in patients with alpha(1)-antitrypsin deficiency (AATD) and respiratory infections...
  85. pmc The pathophysiology of bronchiectasis
    Paul T King
    Department of Medicine, Monash University, Monash Medical Centre, Melbourne, Victoria, Australia
    Int J Chron Obstruct Pulmon Dis 4:411-9. 2009
    b>Bronchiectasis is defined by permanent and abnormal widening of the bronchi. This process occurs in the context of chronic airway infection and inflammation...
  86. ncbi Phenotyping adults with non-cystic fibrosis bronchiectasis: a prospective observational cohort study
    G A Anwar
    Department of Respiratory Medicine, Northumbria Healthcare Trust, Newcastle, UK
    Respir Med 107:1001-7. 2013
    b>Bronchiectasis is the outcome of a number of different airway insults. Very few studies have characterised the aetiology and utility of a dedicated screening proforma in adult patients attending a general bronchiectasis clinic.
  87. ncbi Inhaled steroids improve quality of life in patients with steady-state bronchiectasis
    Miguel A Martínez-García
    Pneumology Unit, Requena General Hospital, Valencia, Spain
    Respir Med 100:1623-32. 2006
    The effects of inhaled steroids upon the quality of life of patients with bronchiectasis remain unknown.
  88. ncbi Mast cells in bronchiectasis
    R Sepper
    Institute of Biomedicine, Department of Anatomy, University of Helsinki
    Ann Med 30:307-15. 1998
    b>Bronchiectasis (BE) is a chronic severe inflammatory lung disease characterized by frequent bacterial infections and polymorphonuclear neutrophil-dominated inflammatory reaction...
  89. ncbi Association between inflammatory markers in induced sputum and clinical characteristics in children with non-cystic fibrosis bronchiectasis
    Tulay Guran
    Department of Pediatrics, Marmara University Faculty of Medicine, Istanbul, Turkey
    Pediatr Pulmonol 42:362-9. 2007
    To study clinical, radiological and laboratory features of children with non-cystic fibrosis (non-CF) bronchiectasis (BE) and the association between symptom scores, spirometry, high-resolution computed tomography (HRCT) findings and ..
  90. ncbi Clinical efficacy and safety of budesonide-formoterol in non-cystic fibrosis bronchiectasis
    Miguel Angel Martínez-García
    Pneumology Unit, La Fe University and Polytechnic Hospital, Av Bulevar Sur s n, 46026, Valencia, Spain
    Chest 141:461-8. 2012
    ..study is to evaluate the efficacy and safety of medium-dose formoterol-budesonide combined inhaled treatment in a single inhaler compared with high-dose budesonide treatment in patients with non-cystic fibrosis (non-CF) bronchiectasis.
  91. ncbi Bronchiectasis: new approaches to diagnosis and management
    Charles Feldman
    Division of Pulmonology, Department of Internal Medicine, Charlotte Maxeke Johannesburg Academic Hospital, University of the Witwatersrand, Parktown, Johannesburg, South Africa
    Clin Chest Med 32:535-46. 2011
    Non-cystic fibrosis (CF) bronchiectasis is a common, potentially serious, condition...
  92. ncbi Pathogenesis of bronchiectasis
    Brian M Morrissey
    Division of Pulmonary Critical Care Medicine, Department of Internal Medicine, School of Medicine, University of California Davis, 4150 V Street, Suite 3400, Sacramento, CA 95817, USA
    Clin Chest Med 28:289-96. 2007
    Cystic fibrosis (CF) typically follows a more severe clinical course than non-CF bronchiectasis. Despite this recognized difference, the underpinnings of respiratory biology support a common pathogeneses of the anatomic deformations of ..
  93. ncbi A pilot study of the safety and efficacy of tobramycin solution for inhalation in patients with severe bronchiectasis
    Paul Scheinberg
    Atlanta Pulmonary Group, 5667 Peachtree Dunwoody Rd, Suite 350, Atlanta, GA 30350, USA
    Chest 127:1420-6. 2005
    To evaluate the efficacy and safety of tobramycin solution for inhalation (TSI) in patients with severe bronchiectasis.
  94. ncbi Bronchiectasis in Central Australia: a young face to an old disease
    Daniel P Steinfort
    Department of Medicine, Alice Springs Hospital, Alice Springs, NT, Australia
    Respir Med 102:574-8. 2008
    b>Bronchiectasis remains a significant cause of morbidity among specific populations world wide, including many indigenous groups. Data on prevalence in Australian adults are lacking...
  95. ncbi Is there a role for inhaled corticosteroids and macrolide therapy in bronchiectasis?
    Paul King
    Monash University, Department of Medicine, Monash Medical Centre, Melbourne, Victoria, Australia
    Drugs 67:965-74. 2007
    b>Bronchiectasis is characterised by permanent dilatation of the bronchi that arises from chronic inflammation predominantly caused by bacterial infection...
  96. ncbi Quality-of-life determinants in patients with clinically stable bronchiectasis
    Miguel Angel Martínez-García
    Pneumology Unit, La Fe University Hospital, Valencia, Spain
    Chest 128:739-45. 2005
    To determine the most important variables influencing health-related quality of life (HRQL) in patients with clinically stable bronchiectasis (SB).
  97. pmc Inhaled fluticasone in bronchiectasis: a 12 month study
    K W Tsang
    Department of Respiratory and Critical Care Medicine, University Department of Medicine, Queen Mary Hospital, Pokfulam Road, Hong Kong
    Thorax 60:239-43. 2005
    The clinical efficacy of inhaled corticosteroid (ICS) treatment has not been evaluated in bronchiectasis, despite the presence of chronic airway inflammation.
  98. ncbi Effects of long-term low-dose azithromycin in patients with non-CF bronchiectasis
    G A Anwar
    North Tyneside General Hospital, Rake Lane, North Shields, NE29 8NH Tyne and Wear, UK
    Respir Med 102:1494-6. 2008
    We describe our institutional efficacy experience of azithromycin 250 mg thrice weekly in adult non-cystic fibrosis bronchiectasis.
  99. ncbi Bronchiectasis in indigenous children in remote Australian communities
    Anne B Chang
    Northern Territory Clinical School, Flinders University, Alice Springs, NT
    Med J Aust 177:200-4. 2002
    The rates of bronchiectasis for Indigenous children from remote Australian communities are unacceptably high, with one study showing 14.7/1000 Aboriginal children...
  100. ncbi New treatment options for bronchiectasis
    Mark L Metersky
    Division of Pulmonary and Critical Care Medicine, University of Connecticut School of Medicine, Farmington, CT 06030 1321, USA
    Ther Adv Respir Dis 4:93-9. 2010
    Therapies shown to be effective in cystic fibrosis are often provided to patients with bronchiectasis, without definitive evidence of benefit...
  101. ncbi Non-cystic fibrosis bronchiectasis in childhood: longitudinal growth and lung function
    C M Bastardo
    Portex Anaesthesia, Intensive Therapy and Respiratory Medicine Unit, UCL, Institute of Child Health, London, UK
    Thorax 64:246-51. 2009
    Non-cystic fibrosis (non-CF) bronchiectasis often starts in childhood with a significant impact on adult morbidity. Little is known about disease progression through childhood and the effect on growth and spirometry...

Research Grants63

  1. Iowa Phase II Clinical Trials of Novel Therapies for Lung Diseases (U01
    Lakshmi Durairaj; Fiscal Year: 2012
    ..promises to be a cheap and effective intervention for several conditions in addition to CF, such as non-CF bronchiectasis, chronic bronchitis and ventilator associated pneumonia...
  2. Polymicrobial interactions in the lung.
    JENNIFER MELINDA BOMBERGER; Fiscal Year: 2010
    ..pulmonary disorder (COPD), community acquired pneumonia (CAP), ventilator-associated pneumonia (VAP), non-CF bronchiectasis and cystic fibrosis (CF). Recent studies suggest that viral and P...
  3. Polymicrobial Interactions in the Lung
    JENNIFER MELINDA BOMBERGER; Fiscal Year: 2013
    ..pulmonary disorder (COPD), community acquired pneumonia (CAP), ventilator-associated pneumonia (VAP), non-CF bronchiectasis and cystic fibrosis (CF). Recent studies suggest that viral and P...
  4. HORMONAL INFLUENCES ON AIRWAY DISEASE
    Raksha Jain; Fiscal Year: 2013
    ..Epidemiologic data indicates that a gender disparity exists in patients with airway diseases including bronchiectasis, asthma, and chronic obstructive lung disease, with women demonstrating worse severity and outcomes along with ..
  5. In vitro and in vivo efficacy of liposomal ciprofloxacin formulations against Myc
    Igor Gonda; Fiscal Year: 2013
    ..by both Mycobacteria are common in patients with chronic lung conditions, such as cystic fibrosis (CF), non-CF bronchiectasis and emphysema. In patients with AIDS, the M. avium infection is disseminated...
  6. Genetic Disorder of Mucocilary Clearance
    Michael R Knowles; Fiscal Year: 2013
    ..These disorders involve chronic airways infection with resultant bronchiectasis. Over the past 4 years, this Consortium has made great progress in studies of variant CF, Primary Ciliary ..
  7. Pilot Studies of Gene Therapy for Primary Ciliary Dyskinesia
    Lawrence E Ostrowski; Fiscal Year: 2010
    ..individuals suffer from a life-long pattern of recurring respiratory infections, ultimately leading to bronchiectasis. Recently, mutations that cause a significant fraction of PCD have been identified in a small number of ..
  8. Real-Time Reagent-Free Noninvasive Diagnosis of Tuberculosis
    Payam Nahid; Fiscal Year: 2013
    ..This makes SPAMS ideal as a diagnostic in TB patients in whom parenchymal damage and bronchiectasis often result in concomitant infection/colonization with other non-TB pathogens...
  9. Early-life arsenic exposure and adult mortality in Region II, Chile
    Allan H Smith; Fiscal Year: 2013
    ..4;95% CI, 1.7 to 6.2) and liver cancer (SMR=3.1;95% CI, 1.8 to 4.9). Non-cancer deaths were increased from bronchiectasis (SMR=25.1;95% CI, 13.4 to 42.9), acute myocardial infarction (SMR=2.4;95% CI, 1.9 to 3...
  10. Viral Pathogenesis of Early Cystic Fibrosis Lung Disease
    SARATH CHANDRA RANGANATHAN; Fiscal Year: 2013
    ..airway modeling techniques will be applied to better detect and measure airway disease that precedes bronchiectasis. We will examine the relationship between viral infections and initial pathophysiological changes in the CF ..
  11. Pseudomonas-Host Interactions in Cystic Fibrosis
    Bruce A Stanton; Fiscal Year: 2013
    ..P. aeruginosa is also an important pathogen in patients with chronic obstructive pulmonary disorder, bronchiectasis, community acquired pneumonia, ventilator-associated pneumonia and cystic fibrosis...
  12. Molecular Characteriszation of a Novel Lung Sphingomyelinase
    Tzipora Goldkorn; Fiscal Year: 2013
    ..cellular apoptosis, a hallmark in the pathogenesis of lung injury in pulmonary diseases such as asthma, bronchiectasis, and chronic obstructive pulmonary disorders...
  13. Antibacterial Perfluorocarbon Ventilation to Treat Severe Respiratory Infections
    KEITH ELLIOT COOK; Fiscal Year: 2013
    ..true for severe cases of pneumonia, bacterial infections superimposed on chronic lung disease states, and bronchiectasis. Antibiotic perfluorocarbon ventilation (APV) could improve treatment of severe bacterial infections if used ..
  14. MOLECULAR ANALYSIS OF FLAGELLAR DYNEIN FUNCTION
    Stephen M King; Fiscal Year: 2013
    ..their regulatory systems lead to a broad array of severe and diverse phenotypes in humans such as infertility, bronchiectasis and situs inversus...
  15. Improving Inhaled Drug Delivery with Self-dispersing Liquids
    STEPHEN GAROFF; Fiscal Year: 2013
    ..The elements of obstruction common to lung diseases such as cystic fibrosis, bronchiectasis, or chronic obstructive pulmonary disease (COPD) can decrease ventilation in portions of the lung, preventing ..
  16. Multi-Dimensional Separation of Bacteria
    G Scott Worthen; Fiscal Year: 2010
    ..species in a complex mixture, such as in clinical infectious illnesses (we are particularly interested in Bronchiectasis and necrpotizing enterocolitis) whose pathogenesis is obscure...
  17. Syndecan-1 in Lung Repair
    Peter Chen; Fiscal Year: 2013
    ..g., asthma remodeling, COPD, obliterative bronchiolitis, bronchiectasis)...
  18. Clinical Development of a Therapeutic Agent for COPD
    Indu Parikh; Fiscal Year: 2013
    ..lung diseases, including chronic pulmonary disease (COPD), asthma, cystic fibrosis, allergic rhinitis, and bronchiectasis. Despite the obvious medical importance, there presently are no effective therapies to control excess mucus ..
  19. Targeting Primary Immune Deficiency in Patient Populations
    Charlotte Cunningham-Rundles; Fiscal Year: 2013
    ..The commonest diagnoses were pneumonia, sepsis, failure to thrive, empyema, and bronchiectasis and osteomyelitis...
  20. Trans-NIH Research Support
    Raymond A Frizzell; Fiscal Year: 2013
    ..liquid is depleted, the clearance of mucus and bacteria from the lungs is impaired, and inflammation and bronchiectasis lead to respiratory failure...
  21. Primary Ciliary Dyskinesia and Overlapping Syndromes
    STEPHANIE DUGGINS DAVIS; Fiscal Year: 2010
    ..clearance, is characterized by recurrent bronchitis, rhinosinusitis, otitis media and development of bronchiectasis. In this disease, the motile cilia, which consists of a configuration of nine outer microtubule pairs and a ..
  22. Mucosal Immunization Against P. aeruginosa by Modified Adenovirus Vectors
    Stefan Worgall; Fiscal Year: 2013
    ..by applicant): Lung infections with Pseudomonas aeruginosa are a significant health problem for patients with bronchiectasis and cystic fibrosis. A vaccine against P. aeruginosa would be useful to prevent colonization and infection...
  23. MACROPHAGE/NEUTROPHIL ELASTASE INHIBITOR
    EILEEN REMOLD O DONNELL; Fiscal Year: 1999
    ..between proteases and proteinase inhibitors at tissue sites plays a role in the pathogenesis of emphysema, bronchiectasis, asthma, chronic bronchitis, sarcoidosis, respiratory distress syndrome, arthritis and some skin diseases...
  24. EPITHELIAL CELL RESPONSE TO H.INFLUENZAE IN THE AIRWAY
    Dwight Look; Fiscal Year: 2003
    ..mucosa and often produces respiratory tract disease, particularly in patients with chronic bronchitis, bronchiectasis, and cystic fibrosis...
  25. Regulation of Airway Goblet Cell Mucin Secretion
    C Davis; Fiscal Year: 2007
    DESCRIPTION: The obstructive pulmonary diseases (OPD), cystic fibrosis, chronic bronchitis, bronchiectasis, emphysema, and asthma, are inflammatory diseases with very different inflammatory cell profiles, cytokine responses, etc; mucin ..
  26. REGULATION OF PULMONARY ELASTIN PRODUCTION BY RETINOIDS
    Stephen McGowan; Fiscal Year: 2000
    Destructive inflammatory lung diseases lung diseases such as emphysema and bronchiectasis can irreversibly alter the elastic properties of the lung by degradation of the structural protein elastin...
  27. Small Molecule Inhibitors of Cilia
    Wallace Marshall; Fiscal Year: 2007
    ..and disease, including polycystic kidney disease, hydrocephalus, syndromic obesity, chronic sinusitis, bronchiectasis, and retinal degeneration...
  28. BRONCHOPULMONARY INFECTION--THE ROLE OF MUCIN
    Reuben Ramphal; Fiscal Year: 1999
    ..importance to the pathologic process which occurs in chronic lung diseases such as cystic fibrosis and bronchiectasis, since this organism does not invade beyond the lungs in these diseases...
  29. AIRWAY SUBMUCOSAL GLANDS AND CYSTIC FIBROSIS DISEASE
    STEPHEN BALLARD; Fiscal Year: 2009
    ..disease which is typified by the production of unusually thick mucus, severe chronic bacterial infections, and bronchiectasis. Unfortunately, the underlying sequence of events which leads to this pattern of pathology is unclear and ..
  30. Regulation of host response genes in pathogenesis of TB
    Jesse Roman; Fiscal Year: 2005
    ..Tissue remodeling is responsible for the development of Mtb- mediated fibrosis, bronchiectasis, and cavitation...
  31. BTP1000 & The Clearance of Mucus From the Lungs
    DONOVAN YEATES; Fiscal Year: 2002
    Patients with chronic bronchitis, bronchiectasis, cystic fibrosis, asthmatic bronchitis and asthma have inspissated mucus and plugs of highly viscoelastic mucus...
  32. BIOLOGY OF PCRV
    Jeanine Wiener Kronish; Fiscal Year: 2004
    ..Also patients who are chronically infected with P. aeruginosa (i.e.: cystic fibrosis, HIV patients and bronchiectasis patients) become resistant to antibiotics and may die from their4 infections...
  33. Noninvasive biomarkers of proteolytic activity in CF
    Scott Sagel; Fiscal Year: 2007
    DESCRIPTION (provided by applicant): In children with cystic fibrosis (CF) proteolytic activity causes bronchiectasis, resulting in progressive lung disease and marked shortening of life expectancy...
  34. MECHANISMS OF HUMAN AIRWAY MUCOUS CELL HYPERPLASIA
    Linda Martin; Fiscal Year: 2004
    ..Mucous cell hyperplasia is common in patients with inflammatory airway diseases including asthma, COPD, bronchiectasis, and cystic fibrosis...
  35. Inhibition of Mucin Secretion in Murine Model of Asthma
    Indu Parikh; Fiscal Year: 2003
    ..airways is a major factor in several lung diseases, including chronic bronchitis, asthma, cystic fibrosis, and bronchiectasis. Despite the obvious medical importance, mechanisms that regulate production and secretion of airway mucus ..
  36. Anti-inflammatory Gene Therapy For Cystic Fibrosis
    Isabel Virella Lowell; Fiscal Year: 2005
    ..These substances include neutrophil elastase (NE), which can cause bronchiectasis, airway obstruction, and impaired clearance of infected secretions...
  37. TRACHEOBRONCHIAL GLYCOPROTEIN STRUCTURE
    Thomas Mawhinney; Fiscal Year: 1991
    ..g., chronic bronchitis, asthma, bronchiectasis, alveolar proteinosis and cystic fibrosis (CF)) will be studied, their structures elucidated and compared so ..
  38. Role of non-tuberculous mycobacteria in lung disease
    Jason Stout; Fiscal Year: 2006
    ..Our second hypothesis is that, at a minimum, radiographicatly identified bronchiectasis will be associated with NTM pulmonary disease...
  39. CYTOKINE/VIRAL GENE INTERACTIONS IN VIRAL LUNG DISEASE
    Joel Kline; Fiscal Year: 1999
    ..Disorders associated with latent infection by these pathogens may include bronchiolitis obliterans, bronchiectasis, the hyperlucent lung syndrome and other forms of chronic obstructive lung disease, and acceleration of graft ..
  40. Biofilm Detachment Mechanisms in Chronic Lung Infections
    Pradeep Singh; Fiscal Year: 2007
    ..aeruginosa biofilms cause many chronic infections including airway infections that afflict bronchiectasis patients, endotracheal tube colonization that leads to ventilator associated pneumonia, medical device ..
  41. EPITHELIAL CELLS IN LUNG INFLAMMATION
    Peter Kao; Fiscal Year: 2003
    Excessive airway inflammation occurs in asthma, bronchitis and bronchiectasis. Local human bronchial epithelial (HBE) cells express chemoattractant cytokines and hematopoietic growth factors that serve to recruit immune effector ..
  42. CA2+, GAP JUNCTIONS & COMMUNICATION IN ALVEOLAR II CELLS
    Scott Boitano; Fiscal Year: 2000
    ..Dysfunction of alveolar II cells, as seen after severe cases of asthma, chronic bronchitis, bronchiectasis, infection or injury, can have serious effects on lung physiology, (e.g...
  43. REGULATION OF THE STIMULATION OF MUCIN GENE EXPRESSION A
    Ja Seok Koo; Fiscal Year: 2003
    ..airways in many inflammatory airway diseases such as asthma, cystic fibrosis, chronic bronchitis, and bronchiectasis. Inhibition of over expressed pathophysiologic mucus is one of the major targets for treatments of airway ..
  44. TRANS-MEMBRANE WATER AND ION MEASUREMENT SYSTEM (TWIMS)
    LID WONG; Fiscal Year: 2004
    ..discovery in fields including but not limited to, 1) respiratory disease such as chronic bronchitis, asthma bronchiectasis and cystic fibrosis; 2) gastrointestinal disease such as diarrhea, cholera infection and severe dehydration; 3)..
  45. Submillimeter Technology for Molecular Biomarkers
    ANJAL SHARMA; Fiscal Year: 2005
    ..of metabolic products in patients with symptoms for a small number of selected diseases including asthma, bronchiectasis, interstitial lung disease...
  46. The Regulation of the G-protein, Galphai2 by UNC5H2.
    Katsumi Komatsuzaki; Fiscal Year: 2003
    ..migration of these cells induces a broad array of lung diseases including interstitial lung disease, ARDS and bronchiectasis. These diseases are responsible for a large number of deaths in the United States...
  47. Strategies to Prevent COPD Exacerbation
    Fernando Martinez; Fiscal Year: 2007
    ..and cystic fibrosis, while preliminary positive results have been demonstrated in patients with bronchiectasis and COPD...
  48. Arsenic and child respiratory health in Bangladesh
    Allan H Smith; Fiscal Year: 2010
    ....
  49. IMPACT OF ARSENIC ON MORTALITY IN CHILE FROM 1950-2000
    ALLAN SMITH; Fiscal Year: 2002
    ..This study will provide a unique opportunity to investigate arsenic-caused mortality, including latency patterns, in one of the world's most significant environmental toxic exposures. ..
  50. California Nevada Arsenic and Lung Cancer Study
    ALLAN SMITH; Fiscal Year: 2005
    ....
  51. REGULATION OF MUCIN GENE EXPRESSION BY ELASTASE
    Judith Voynow; Fiscal Year: 2003
    ..The ultimate goal is to use information from this project to identify new biologic targets for therapeutic interventions to prevent mucus obstruction in chronic inflammatory airway diseases. ..
  52. Phase 2 Study of PEG-Intron in Hereditary Hemorrhagic T*
    Karen Swanson; Fiscal Year: 2008
    ..Patients can die from refractory liver failure and heart failure. Patients with diffuse pulmonary involvement have significant hypoxemia and exercise tolerance may be affected with treatment. [unreadable] [unreadable]..
  53. VOLATILE MARKERS OF PULMONARY TUBERCULOSIS IN THE BREATH
    Michael Phillips; Fiscal Year: 2006
    ..Also, it could potentially reduce the mortality and morbidity caused by pulmonary TB. [unreadable] [unreadable] [unreadable]..
  54. Mucin Gene Regulation by Elastase and Oxidants
    Judith Voynow; Fiscal Year: 2008
    ..b. To determine whether NE and/or NQO1-generated ROS affect HuR binding to MUC5AC. c. To determine whether HuR binding is sufficient for MUC5AC mRNA stabilization. ..
  55. MUC4 Mucin and Airway Epithelial Regeneration in COPD
    Judith Voynow; Fiscal Year: 2006
    ..Our ultimate goal is to use information from this project to identify new biologic targets for rational therapies to induce normal airway epithelial proliferation and differentiation following injury. ..
  56. Cellular Mechanisms for Tubuloglomerular Feedback
    Phillip Bell; Fiscal Year: 2009
    ..Overall these studies should provide important new information regarding the role of ATP in macula densa signaling, activation of the tubuloglomerular feedback mechanism, and control of glomerular hemodynamics. ..
  57. PHOSPHOLIPASE ACTIVATION IN ASPIRIN INTOLERANT ASTHMA
    ESTHER LANGMACK; Fiscal Year: 2002
    ..Dr. Langmack's collaborators for this project include Dr. Robert Murphy, Dr. Christina Leslie, and Dr. Jay Westcott, who will share their expertise in lipid mediator analysis. (End of Abstract) ..
  58. Centriole Orientation During Left/Right Symmetry Breaking in the Mouse
    Wallace Marshall; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  59. Targeted Delivery of Interleukin-10
    Thomas Ferkol; Fiscal Year: 2004
    ..abstract_text> ..
  60. Genetic Modifiers of Cystic Fibrosis
    Michael Boyle; Fiscal Year: 2007
    ..Last, we will evaluate three of the strongest current CF candidate modifier genes to determine if the distribution of their functional alleles segregates with severity of lung disease in our CF clinic population. ..
  61. Clearance of Apoptotic Cells in Cystic Fibrosis
    RICHARD VANDIVIER; Fiscal Year: 2007
    ....
  62. Genetic variants of primary ciliary dyskinesia
    Thomas Ferkol; Fiscal Year: 2006
    ..Using this approach, we will define the genetic spectrum of PCD, and correlate specific genetic variants with clinical presentations of this disease, especially during the neonatal period. ..
  63. DETERMINANTS OF EXACERBATION FREQUENCY IN PATIENTS WITH*
    Jadwiga Wedzicha; Fiscal Year: 2007
    ..abstract_text> ..