bronchial hyperreactivity

Summary

Summary: Tendency of the smooth muscle of the tracheobronchial tree to contract more intensely in response to a given stimulus than it does in the response seen in normal individuals. This condition is present in virtually all symptomatic patients with asthma. The most prominent manifestation of this smooth muscle contraction is a decrease in airway caliber that can be readily measured in the pulmonary function laboratory.

Top Publications

  1. ncbi Interleukin-13: central mediator of allergic asthma
    M Wills-Karp
    Department of Environmental Health Sciences, Johns Hopkins University School of Hygiene and Public Health, Baltimore, MD 21205, USA
    Science 282:2258-61. 1998
  2. pmc Requirement for IL-13 independently of IL-4 in experimental asthma
    G Grunig
    Department of Medicine, San Francisco General Hospital, University of California San Francisco, San Francisco, CA 94143, USA
    Science 282:2261-3. 1998
  3. ncbi Continuous exposure to house dust mite elicits chronic airway inflammation and structural remodeling
    Jill R Johnson
    Department of Pathology and Molecular Medicine, Center for Gene Therapeutics, Millennium Pharmaceuticals, Cambridge, Massachusetts, USA
    Am J Respir Crit Care Med 169:378-85. 2004
  4. ncbi Protease-activated receptor 2 mediates eosinophil infiltration and hyperreactivity in allergic inflammation of the airway
    Fabien Schmidlin
    Department of Surgery and Physiology, University of California, San Francisco 94143, USA
    J Immunol 169:5315-21. 2002
  5. pmc A sensory neuronal ion channel essential for airway inflammation and hyperreactivity in asthma
    Ana I Caceres
    Department of Pharmacology, Yale University School of Medicine, 333 Cedar St, New Haven, CT 06520, USA
    Proc Natl Acad Sci U S A 106:9099-104. 2009
  6. ncbi The link between allergic rhinitis and asthma: the united airways disease
    Enrico Compalati
    Allergy and Respiratory Diseases Clinic, Dept of Internal Medicine, University of Genova, Italy
    Expert Rev Clin Immunol 6:413-23. 2010
  7. pmc A novel subset of mouse NKT cells bearing the IL-17 receptor B responds to IL-25 and contributes to airway hyperreactivity
    Asuka Terashima
    Laboratory for Immune Regulation, RIKEN Research Center for Allergy and Immunology, Yokohama, Kanagawa, Japan
    J Exp Med 205:2727-33. 2008
  8. pmc TLR4 is necessary for hyaluronan-mediated airway hyperresponsiveness after ozone inhalation
    Stavros Garantziotis
    National Institute of Environmental Health Sciences, Research Triangle Park, Durham, North Carolina, USA
    Am J Respir Crit Care Med 181:666-75. 2010
  9. ncbi Direct effects of interleukin-13 on epithelial cells cause airway hyperreactivity and mucus overproduction in asthma
    Douglas A Kuperman
    Lung Biology Center, Department of Medicine and Cardiovascular Research Institute, University of California San Francisco School of Medicine, San Francisco, California, USA
    Nat Med 8:885-9. 2002
  10. ncbi Development of spontaneous airway changes consistent with human asthma in mice lacking T-bet
    Susetta Finotto
    Critical Care and Pulmonary Division, Division of Gastroenterology, Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Science 295:336-8. 2002

Detail Information

Publications321 found, 100 shown here

  1. ncbi Interleukin-13: central mediator of allergic asthma
    M Wills-Karp
    Department of Environmental Health Sciences, Johns Hopkins University School of Hygiene and Public Health, Baltimore, MD 21205, USA
    Science 282:2258-61. 1998
    ..Thus, IL-13 is critical to allergen-induced asthma but operates through mechanisms other than those that are classically implicated in allergic responses...
  2. pmc Requirement for IL-13 independently of IL-4 in experimental asthma
    G Grunig
    Department of Medicine, San Francisco General Hospital, University of California San Francisco, San Francisco, CA 94143, USA
    Science 282:2261-3. 1998
    ..This pathway may underlie the genetic associations of asthma with both the human 5q31 locus and the IL-4 receptor...
  3. ncbi Continuous exposure to house dust mite elicits chronic airway inflammation and structural remodeling
    Jill R Johnson
    Department of Pathology and Molecular Medicine, Center for Gene Therapeutics, Millennium Pharmaceuticals, Cambridge, Massachusetts, USA
    Am J Respir Crit Care Med 169:378-85. 2004
    ..Finally, these responses were studied for up to 9 weeks after cessation of HDM exposure. We observed that whereas airway inflammation resolved fully, the remodeling changes did not resolve and airway hyperreactivity resolved only partly...
  4. ncbi Protease-activated receptor 2 mediates eosinophil infiltration and hyperreactivity in allergic inflammation of the airway
    Fabien Schmidlin
    Department of Surgery and Physiology, University of California, San Francisco 94143, USA
    J Immunol 169:5315-21. 2002
    ..Thus, PAR2 contributes to the development of immunity and to allergic inflammation of the airway. Our results support the proposal that tryptase inhibitors and PAR2 antagonists may be useful therapies for inflammatory airway disease...
  5. pmc A sensory neuronal ion channel essential for airway inflammation and hyperreactivity in asthma
    Ana I Caceres
    Department of Pharmacology, Yale University School of Medicine, 333 Cedar St, New Haven, CT 06520, USA
    Proc Natl Acad Sci U S A 106:9099-104. 2009
    ..TRPA1 may represent a promising pharmacological target for the treatment of asthma and other allergic inflammatory conditions...
  6. ncbi The link between allergic rhinitis and asthma: the united airways disease
    Enrico Compalati
    Allergy and Respiratory Diseases Clinic, Dept of Internal Medicine, University of Genova, Italy
    Expert Rev Clin Immunol 6:413-23. 2010
    ..Treatment of established rhinitis may affect asthma control and could have some impact on airway obstruction, but a direct effect of rhinitis therapy on lower airway inflammation remains to be clearly established...
  7. pmc A novel subset of mouse NKT cells bearing the IL-17 receptor B responds to IL-25 and contributes to airway hyperreactivity
    Asuka Terashima
    Laboratory for Immune Regulation, RIKEN Research Center for Allergy and Immunology, Yokohama, Kanagawa, Japan
    J Exp Med 205:2727-33. 2008
    ..These results strongly suggest that IL-17RB(+) CD4(+) NKT cells play a crucial role in the pathogenesis of asthma...
  8. pmc TLR4 is necessary for hyaluronan-mediated airway hyperresponsiveness after ozone inhalation
    Stavros Garantziotis
    National Institute of Environmental Health Sciences, Research Triangle Park, Durham, North Carolina, USA
    Am J Respir Crit Care Med 181:666-75. 2010
    ..However, the relation between TLR4 and hyaluronan in the airway response to ozone remains unexplored...
  9. ncbi Direct effects of interleukin-13 on epithelial cells cause airway hyperreactivity and mucus overproduction in asthma
    Douglas A Kuperman
    Lung Biology Center, Department of Medicine and Cardiovascular Research Institute, University of California San Francisco School of Medicine, San Francisco, California, USA
    Nat Med 8:885-9. 2002
    ..These results demonstrate the importance of direct effects of IL-13 on epithelial cells in causing two central features of asthma...
  10. ncbi Development of spontaneous airway changes consistent with human asthma in mice lacking T-bet
    Susetta Finotto
    Critical Care and Pulmonary Division, Division of Gastroenterology, Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Science 295:336-8. 2002
    ..Thus, T-bet deficiency, in the absence of allergen exposure, induces a murine phenotype reminiscent of both acute and chronic human asthma...
  11. ncbi Adiponectin attenuates allergen-induced airway inflammation and hyperresponsiveness in mice
    Stephanie A Shore
    Physiology Program, Department of Environmental Health, Harvard School of Public Health, 665 Huntington Avenue, Boston, MA 02115, USA
    J Allergy Clin Immunol 118:389-95. 2006
    ..Epidemiologic data indicate an increased incidence of asthma in the obese...
  12. pmc Bronchial hyperresponsiveness and the development of asthma and COPD in asymptomatic individuals: SAPALDIA cohort study
    M H Brutsche
    Pneumologie, University Hospital Basel, Petersgraben 4, CH 4031 Basel, Switzerland
    Thorax 61:671-7. 2006
    ..We hypothesised that BHR might play a role in the development of chronic obstructive pulmonary disease (COPD) as well as asthma...
  13. ncbi Hierarchical suppression of asthma-like responses by mucosal tolerance
    Alexandre C Keller
    Department of Immunology, Biomedical Science Institute, University of Sao Paulo, Brazil
    J Allergy Clin Immunol 117:283-90. 2006
    ..Mucosal tolerance can be induced by oral or nasal administration of soluble proteins and results in the suppression of cellular and/or humoral immune responses to the specific antigen...
  14. ncbi Anti-interleukin-9 antibody treatment inhibits airway inflammation and hyperreactivity in mouse asthma model
    Gang Cheng
    Department of Pulmonary Medicine, Dokkyo University School of Medicine, Mibu machi, Shimotsuga gun, Tochigi 321 0293, Japan
    Am J Respir Crit Care Med 166:409-16. 2002
    ..Taken together, our findings emphasize the importance of IL-9 in the pathogenesis of asthma and suggest that blockade of IL-9 may be a new therapeutic strategy for bronchial asthma...
  15. ncbi Beneficial effects of high dose of L-arginine on airway hyperresponsiveness and airway inflammation in a murine model of asthma
    Ulaganathan Mabalirajan
    Molecular Immunogenetics Laboratory and Centre of Excellence for Translational Research in Asthma and Lung Disease, Institute of Genomics and Integrative Biology, Delhi, India
    J Allergy Clin Immunol 125:626-35. 2010
    ....
  16. pmc Pathophysiological features of asthma develop in parallel in house dust mite-exposed neonatal mice
    Sejal Saglani
    Leukocyte Biology Section, National Heart and Lung Institute, Sir Alexander Fleming Building, Imperial College London, Exhibition Road, London SW7 2AZ, UK
    Am J Respir Cell Mol Biol 41:281-9. 2009
    ..Importantly, all abnormalities developed in parallel, not sequentially, between 2 and 3 weeks of age...
  17. pmc Particulate matter-induced airway hyperresponsiveness is lymphocyte dependent
    Vanessa Saunders
    Division of Immunobiology, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio 45229, USA
    Environ Health Perspect 118:640-6. 2010
    ..However, the mechanism(s) by which it induces these features of asthma remains unknown...
  18. ncbi Airway hyperresponsiveness is associated with activated CD4+ T cells in the airways
    Graeme R Zosky
    Telethon Institute for Child Health Research and Centre for Child Health Research, University of Western Australia, Australia
    Am J Physiol Lung Cell Mol Physiol 297:L373-9. 2009
    ..There was no evidence that antigen-specific antibody had a synergistic effect in this model, and we concluded that the number of antigen-specific T cells activated and recruited to the airway wall was crucial for development of AHR...
  19. ncbi Modulation of ozone-induced airway hyperresponsiveness and inflammation by interleukin-13
    A S Williams
    Experimental Studies, Airway Disease Section, National Heart and Lung Institute, Guy Scadding Building, Dovehouse St, London SW3 6LY, UK
    Eur Respir J 32:571-8. 2008
    ..In conclusion, interleukin-13 augments ozone-induced airway hyperresponsiveness and neutrophilic inflammation, possibly through modulation of certain cytokines induced by ozone exposure...
  20. ncbi Analyses of associations with asthma in four asthma population samples from Canada and Australia
    Denise Daley
    James Hogg iCAPTURE Center, University of British Columbia UBC, 1081 Burrard Street, Vancouver, BC, V6Z 1Y6, Canada
    Hum Genet 125:445-59. 2009
    ..To aid in future replication studies of asthma genes a comprehensive database was compiled and is available to the scientific community at http://genapha.icapture.ubc.ca/...
  21. ncbi Effect of passive smoking on respiratory symptoms, bronchial responsiveness, lung function, and total serum IgE in the European Community Respiratory Health Survey: a cross-sectional study
    C Janson
    Department of Medical Sciences, Respiratory Medicine and Allergology, Uppsala University, Akademiska sjukhuset, Uppsala, Sweden
    Lancet 358:2103-9. 2001
    ..This analysis aimed to estimate the effect of passive smoking on respiratory symptoms, bronchial responsiveness, lung function, and total serum IgE in the European Community Respiratory Health Survey...
  22. ncbi Role of TLR2, TLR4, and MyD88 in murine ozone-induced airway hyperresponsiveness and neutrophilia
    Alison S Williams
    Experimental Studies Section, National Heart and Lung Institute, Imperial College London, Dovehouse St, London SW3 6LY, United Kingdom
    J Appl Physiol (1985) 103:1189-95. 2007
    ..Therefore, ozone may induce murine AHR and neutrophilic inflammation through the activation of the Toll-like receptor pathway that may sense noninfectious stimuli such as oxidative stress...
  23. pmc The safety and efficacy of inhaled dry powder mannitol as a bronchial provocation test for airway hyperresponsiveness: a phase 3 comparison study with hypertonic (4.5%) saline
    John D Brannan
    Department of Respiratory Medicine, 11 West, Royal Prince Alfred Hospital, Camperdown NSW 2050, Australia
    Respir Res 6:144. 2005
    ..The safety and the efficacy of mannitol (M) as a BPT to measure airway hyperresponsiveness were compared to hypertonic (4.5%) saline (HS) in people both with and without signs and symptoms of asthma...
  24. ncbi Risk factors for onset of asthma: a 12-year prospective follow-up study
    Celeste Porsbjerg
    Respiratory Unit, Dept of Internal Medicine, Bispebjerg Hospital, Bispebjerg Bakke 23, 2400 Copenhagen NV, Denmark
    Chest 129:309-16. 2006
    ..Asthma development and prognosis have been studied extensively in at-risk populations, but knowledge of the natural history of asthma in the general population is limited...
  25. ncbi Marked airway eosinophilia prevents development of airway hyper-responsiveness during an allergic response in IL-5 transgenic mice
    Takao Kobayashi
    Division of Allergic Diseases, Department of Internal Medicine, Mayo Clinic, Rochester, MN 55905, USA
    J Immunol 170:5756-63. 2003
    ..Overall, the roles of eosinophils in asthma and in animal models need to be addressed carefully for their potentially detrimental and beneficial effects...
  26. pmc Effect of ageing on pulmonary inflammation, airway hyperresponsiveness and T and B cell responses in antigen-sensitized and -challenged mice
    Paula J Busse
    Department of Medicine, Division of Clinical Immunology, Mount Sinai School of Medicine, New York, NY, USA
    Clin Exp Allergy 37:1392-403. 2007
    ..The effect of ageing on several pathologic features of allergic asthma (pulmonary inflammation, eosinophilia, mucus hypersecretion), and their relationship with airway hyperresponsiveness (AHR) is not well characterized...
  27. pmc Spontaneous airway hyperresponsiveness in estrogen receptor-alpha-deficient mice
    Michelle A Carey
    Division of Intramural Research, NIH NIEHS, Triangle Park, NC 27709, USA
    Am J Respir Crit Care Med 175:126-35. 2007
    ..Airway hyperresponsiveness is a critical feature of asthma. Substantial epidemiologic evidence supports a role for female sex hormones in modulating lung function and airway hyperresponsiveness in humans...
  28. pmc Blocking the leukotriene B4 receptor 1 inhibits late-phase airway responses in established disease
    Koichi Waseda
    Department of Hematology, Oncology, Allergy and Respiratory Medicine, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan
    Am J Respir Cell Mol Biol 45:851-7. 2011
    ..These data identify the importance of the LTB4-BLT1 pathway in the development of late-phase, allergen-induced airway responsiveness after secondary airway challenge in mice with established airway disease...
  29. pmc Alveolar macrophages stimulate enhanced cytokine production by pulmonary CD4+ T-lymphocytes in an exacerbation of murine chronic asthma
    Cristan Herbert
    Inflammation and Infection Research Centre, Schoolof Medical Sciences, University of New South Wales, Sydney, Australia
    Am J Pathol 177:1657-64. 2010
    ..We conclude that in an acute exacerbation of asthma, enhanced cytokine expression by AM may play a critical role in triggering increased expression of cytokines by pulmonary CD4(+) T-lymphocytes...
  30. ncbi Induction of vascular remodeling in the lung by chronic house dust mite exposure
    Kristina Rydell-Törmänen
    Department of Experimental Medical Science, Division of Vascular and Airway Research, BMC D12, S 22184 Lund, Sweden
    Am J Respir Cell Mol Biol 39:61-7. 2008
    ..We conclude that respiratory HDME exposure induces airway remodeling and pulmonary vascular remodeling, and, in accordance with airway remodeling, some components of these structural changes may be irreversible...
  31. ncbi Blocking IL-25 prevents airway hyperresponsiveness in allergic asthma
    Sarah J Ballantyne
    Medical Research Council Laboratory of Molecular Biology, Cambridge, United Kingdom
    J Allergy Clin Immunol 120:1324-31. 2007
    ..Its roles in antigen-driven airway inflammation and airway hyperresponsiveness (AHR) remain to be fully established...
  32. ncbi Role of local pulmonary IFN-gamma expression in murine allergic airway inflammation
    Markus Koch
    Department of Immunology, Max Planck Institute for Infection Biology, Campus Charite Mitte, Schumannstrasse 21 22, 10117 Berlin, Germany
    Am J Respir Cell Mol Biol 35:211-9. 2006
    ..Local expression of IFN-gamma in the lung increases markers of allergic airway inflammation, but decreases airway hyperresponsiveness in a murine model of allergic-asthma...
  33. pmc Natural killer T cells are not the predominant T cell in asthma and likely modulate, not cause, asthma
    Seddon Y Thomas
    Department of Pathology, Committee on Immunology, Howard Hughes Medical Institute, University of Chicago, Chicago, Illinois, USA
    J Allergy Clin Immunol 125:980-4. 2010
    ....
  34. pmc Apolipoprotein E negatively regulates house dust mite-induced asthma via a low-density lipoprotein receptor-mediated pathway
    Xianglan Yao
    Pulmonary and Vascular Medicine Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892 1590, USA
    Am J Respir Crit Care Med 182:1228-38. 2010
    ..Distinct sets of corticosteroid-unresponsive genes modulate disease severity in asthma...
  35. pmc Mucosal sensitization to German cockroach involves protease-activated receptor-2
    Kristen Page
    Department of Pediatrics, Cincinnati Children s Hospital Medical Center, University of Cincinnati, Cincinnati, OH, USA
    Respir Res 11:62. 2010
    ..The role for PAR-2 in mediating allergic airway inflammation has not been assessed using a real world allergen...
  36. ncbi Anti-inflammatory and anti-allergic effects of kefir in a mouse asthma model
    Mee Young Lee
    Natural Medicine Research Center, Korea Research Institute of Bioscience and Biotechnology, P O Box 115, Yusung, Daejeon 305 600, Korea
    Immunobiology 212:647-54. 2007
    ..Kefir displayed anti-inflammatory and anti-allergic effects in a mouse asthma model and may possess new therapeutic potential for the treatment of allergic bronchial asthma...
  37. ncbi Airway hyperreactivity in exacerbation of chronic asthma is independent of eosinophilic inflammation
    Jessica S Siegle
    Department of Pathology, University of New South Wales, Sydney, Australia
    Am J Respir Cell Mol Biol 35:565-70. 2006
    ..The inflammatory response involves distal airways and is associated with a distinct pattern of AHR, which develops independent of the enhanced eosinophilic inflammation...
  38. pmc Effect of variation in CHI3L1 on serum YKL-40 level, risk of asthma, and lung function
    Carole Ober
    University of Chicago, Chicago, IL 60637, USA
    N Engl J Med 358:1682-91. 2008
    ..We hypothesized that single-nucleotide polymorphisms (SNPs) that affect YKL-40 levels also influence asthma status and lung function...
  39. ncbi Remodeling and airway hyperresponsiveness but not cellular inflammation persist after allergen challenge in asthma
    Harsha H Kariyawasam
    Allergy and Clinical Immunology, Leukocyte Biology Section, Sir Alexander Fleming Building, Imperial College London, London, UK
    Am J Respir Crit Care Med 175:896-904. 2007
    ..Cellular inflammation and airway remodeling are increased 24 hours after allergen challenge...
  40. ncbi Dysfunction and remodeling of the mouse airway persist after resolution of acute allergen-induced airway inflammation
    Richard Leigh
    Firestone Institute for Respiratory Health, Department of Medicine and Center for Gene Therapeutics, Hamilton, Ontario, Canada
    Am J Respir Cell Mol Biol 27:526-35. 2002
    ....
  41. ncbi Diet-induced obesity causes innate airway hyperresponsiveness to methacholine and enhances ozone-induced pulmonary inflammation
    Richard A Johnston
    Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts, USA
    J Appl Physiol (1985) 104:1727-35. 2008
    ..However, mice with DIO must remain obese for an extended period of time before this pulmonary phenotype is observed...
  42. ncbi Association between neutrophilic airway inflammation and airflow limitation in adults with asthma
    Dominick E Shaw
    Institute for Lung Health, Department of Respiratory Medicine and Thoracic Surgery, Glenfield Hospital, Leicester LE3 9QP, UK
    Chest 132:1871-5. 2007
    ..Chronic inflammation is assumed to be important, although there is limited and contradictory information about the relationship between airway inflammation and postbronchodilator FEV1...
  43. ncbi Modulation of calcium signaling by interleukin-13 in human airway smooth muscle: role of CD38/cyclic adenosine diphosphate ribose pathway
    Deepak A Deshpande
    Department of Veterinary Pathobiology, University of Minnesota, St Paul, MN, USA
    Am J Respir Cell Mol Biol 31:36-42. 2004
    ..These findings indicate that the CD38/cADPR-dependent pathway has a major role in IL-13-induced modulation of calcium signaling in human ASM...
  44. ncbi Functionally important role for arginase 1 in the airway hyperresponsiveness of asthma
    Michelle L North
    Institutes of Medical Sciences, Dalla Lana School of Public Health, Faculty of Medicine, Ontario, Canada
    Am J Physiol Lung Cell Mol Physiol 296:L911-20. 2009
    ....
  45. pmc Serum vitamin D levels and severe asthma exacerbations in the Childhood Asthma Management Program study
    John M Brehm
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, Mass, USA
    J Allergy Clin Immunol 126:52-8.e5. 2010
    ..Vitamin D status might play a role in preventing asthma exacerbations...
  46. pmc Hyaluronan mediates ozone-induced airway hyperresponsiveness in mice
    Stavros Garantziotis
    NIEHS, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    J Biol Chem 284:11309-17. 2009
    ..These data support the conclusion that pulmonary matrix can contribute to the development of airway hyperresponsiveness...
  47. pmc PI3K gamma-deficient mice have reduced levels of allergen-induced eosinophilic inflammation and airway remodeling
    Dae Hyun Lim
    Department of Medicine, University of California San Diego, San Diego, CA, USA
    Am J Physiol Lung Cell Mol Physiol 296:L210-9. 2009
    ..Overall, this study demonstrates an important role for PI3Kgamma in mediating allergen-induced eosinophilic airway inflammation and airway remodeling, suggesting that PI3Kgamma may be a novel therapeutic target in asthma...
  48. pmc Regulation of IL-9 expression by IL-25 signaling
    Pornpimon Angkasekwinai
    Department of Immunology, University of Texas and MD Anderson Cancer Center, Houston, Texas, USA
    Nat Immunol 11:250-6. 2010
    ..In vivo, the IL-25-IL-17RB pathway regulates IL-9 expression in allergic airway inflammation. Thus, IL-25 is a newly identified regulator of IL-9 expression...
  49. ncbi Short-term smoke exposure attenuates ovalbumin-induced airway inflammation in allergic mice
    Barbro N Melgert
    Department of Pathology and Laboratory Medicine, University Hospital Groningen, P O Box 30 001, 9700 RB, Groningen, The Netherlands
    Am J Respir Cell Mol Biol 30:880-5. 2004
    ..This effect of smoking may be different for long-term smoking, in which remodeling effects of smoking can be expected to interrelate with remodeling changes caused by asthmatic disease...
  50. ncbi TIM-1 induces T cell activation and inhibits the development of peripheral tolerance
    Sarah E Umetsu
    Department of Pediatrics, Stanford University, Stanford, California 94305, USA
    Nat Immunol 6:447-54. 2005
    ..Our studies suggest that immunotherapies that regulate TIM-1 function may downmodulate allergic inflammatory diseases...
  51. ncbi Role of oxidative stress in ultrafine particle-induced exacerbation of allergic lung inflammation
    Francesca Alessandrini
    Division of Environmental Dermatology and Allergy, Helmholtz Zentrum Technische Universität München, ZAUM Center for Allergy and Environment, Helmholtz Zentrum Munchen, Neuherberg, Germany
    Am J Respir Crit Care Med 179:984-91. 2009
    ..The effects of ultrafine particle inhalation on allergic airway inflammation are of growing interest. The mechanisms underlying these effects are currently under investigation...
  52. pmc Maternal exposure to particulate matter increases postnatal ozone-induced airway hyperreactivity in juvenile mice
    Richard L Auten
    Neonatal Medicine, Department of Pediatrics, Duke University, Durham, North Carolina, USA
    Am J Respir Crit Care Med 180:1218-26. 2009
    ..Epidemiologic studies implicate air pollutant exposure during pregnancy as a risk factor for wheezing in offspring. Ozone exposure is linked to exacerbations of wheezing in children...
  53. pmc CXCR2 is required for neutrophilic airway inflammation and hyperresponsiveness in a mouse model of human rhinovirus infection
    Deepti R Nagarkar
    Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI 48109 5688, USA
    J Immunol 183:6698-707. 2009
    ..We conclude that CXCR2 is required for RV-induced neutrophilic airway inflammation and that neutrophil TNF-alpha release is required for airway hyperresponsiveness...
  54. ncbi Differential effects of (S)- and (R)-enantiomers of albuterol in a mouse asthma model
    William R Henderson
    Department of Medicine, University of Washington, Seattle, WA 98109, USA
    J Allergy Clin Immunol 116:332-40. 2005
    ..The (R)-enantiomer binds to the beta2-adrenergic receptor with greater affinity than the (S)-enantiomer and is responsible for albuterol's bronchodilating activity. (S)-Albuterol augments bronchospasm and has proinflammatory actions...
  55. pmc Abrogation of bronchial eosinophilic inflammation and airway hyperreactivity in signal transducers and activators of transcription (STAT)6-deficient mice
    T Akimoto
    New Product Research Laboratories IV, Daiichi Pharmaceutical Co, Ltd, 1 16 13 Kitakasai, Edogawa, Tokyo 134, Japan
    J Exp Med 187:1537-42. 1998
    ..Moreover STAT6-/- mice had much less airway reactivity than wild-type mice. These findings suggest that STAT6 plays a crucial role in the pathogenesis of allergen-induced airway inflammation...
  56. pmc Human rhinovirus 1B exposure induces phosphatidylinositol 3-kinase-dependent airway inflammation in mice
    Dawn C Newcomb
    Medical Sciences Research Building II, 1150 W Medical Center Drive, Room 3570B, Ann Arbor, MI 48109 0688, USA
    Am J Respir Crit Care Med 177:1111-21. 2008
    ..Infection with rhinovirus (RV) triggers exacerbations of asthma and chronic obstructive lung disease...
  57. pmc Overexpression of Smad2 drives house dust mite-mediated airway remodeling and airway hyperresponsiveness via activin and IL-25
    Lisa G Gregory
    Leukocyte Biology Section, NHLI, Imperial College London, London SW7 2AZ, UK
    Am J Respir Crit Care Med 182:143-54. 2010
    ..Interactions between the airway epithelium and environmental allergens are believed to be important in driving development of pathology, particularly because altered epithelial gene expression is common in individuals with asthma...
  58. pmc Rhinovirus infection of allergen-sensitized and -challenged mice induces eotaxin release from functionally polarized macrophages
    Deepti R Nagarkar
    Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI 48109, USA
    J Immunol 185:2525-35. 2010
    ..These data provide a new paradigm to explain RV-induced asthma exacerbations...
  59. ncbi Role of interleukin-6 in murine airway responses to ozone
    Richard A Johnston
    Bldg 1, Rm 1304A, Physiology Program, Department of Environmental Health, Harvard School of Public Health, 665 Huntington Ave, Boston, MA 02115 6021, USA
    Am J Physiol Lung Cell Mol Physiol 288:L390-7. 2005
    ..Our results indicate that IL-6 deficiency reduces airway neutrophilia, as well as the levels of BALF sTNFR1 and sTNFR2 following acute high dose and/or subacute low-dose O(3) exposure, but has no effect on O(3)-induced AHR...
  60. ncbi IL-4 induces IL-13-independent allergic airway inflammation
    Charles Perkins
    Division of Immunology, University of Cincinnati College of Medicine, 231 Albert Sabin Way, Cincinnati, OH 45267, USA
    J Allergy Clin Immunol 118:410-9. 2006
    ..The nonredundant role of IL-13 could reflect unique IL-13 activation of a signaling pathway, inhibitory effects induced by IL-4 but not IL-13, or greater production-potency of IL-13 than IL-4...
  61. ncbi Intervention of thymus and activation-regulated chemokine attenuates the development of allergic airway inflammation and hyperresponsiveness in mice
    S Kawasaki
    Department of Respiratory Medicine, School of Medicine, University of Tokyo, Tokyo, Japan
    J Immunol 166:2055-62. 2001
    ..This study also represents the first success in controlling Th2 cytokine production in vivo by targeting a chemokine...
  62. ncbi A longitudinal, population-based, cohort study of childhood asthma followed to adulthood
    Malcolm R Sears
    Firestone Institute for Respiratory Health, Department of Medicine, McMaster University and St Joseph s Healthcare, Hamilton, Ont, Canada
    N Engl J Med 349:1414-22. 2003
    ..The outcome of childhood asthma in adults has been described in high-risk cohorts, but few population-based studies have reported the risk factors for persistence and relapse...
  63. ncbi CD23 exhibits negative regulatory effects on allergic sensitization and airway hyperresponsiveness
    A Haczku
    Division of Basic Sciences, Department of Pediatrics, National Jewish Medical and Research Center, Denver, Colorado 80206, USA
    Am J Respir Crit Care Med 161:952-60. 2000
    ....
  64. pmc Rapid activation of nuclear factor-kappaB in airway epithelium in a murine model of allergic airway inflammation
    Matthew E Poynter
    Vermont Lung Center and Department of Pathology, University of Vermont, Burlington 05405, USA
    Am J Pathol 160:1325-34. 2002
    ..These studies strengthen the potential importance of the bronchiolar epithelial cell as a source of production of NF-kappaB-dependent mediators that play a role in asthma...
  65. ncbi Prostaglandin D2 as a mediator of allergic asthma
    T Matsuoka
    Department of Pharmacology, Kyoto University Faculty of Medicine, Kyoto 606 8501, Japan
    Science 287:2013-7. 2000
    ..helper cells that produce type 2 (TH2) cytokines and is characterized by infiltration of eosinophils and bronchial hyperreactivity. This disease is often triggered by mast cells activated by immunoglobulin E (IgE)-mediated allergic ..
  66. ncbi Toll-like receptor stimulation induces airway hyper-responsiveness to bradykinin, an effect mediated by JNK and NF-kappa B signaling pathways
    Ofir Bachar
    Department of Otorhinolaryngology, Malmo University Hospital, Malmo, Sweden
    Eur J Immunol 34:1196-207. 2004
    ..Costimulation of these receptors results in NF-kappa B- and JNK-mediated transcription of B(1) and B(2) receptor, inducing hyper-responsiveness to bradykinin...
  67. ncbi Inflammation and structural changes in the airways of patients with atopic and nonatopic asthma. BHR Group
    K Amin
    Section of Human Anatomy, Department of Medical Cell Biology, University of Uppsala, Sweden
    Am J Respir Crit Care Med 162:2295-301. 2000
    ..This suggests that there are differences in the extent of the immunopathologic response of these clinically distinct forms of asthma...
  68. pmc Relationship between exposure to domestic allergens and bronchial hyperresponsiveness in non-sensitised, atopic asthmatic subjects
    S J Langley
    Medicines Evaluation Unit, North West Lung Centre, Wythenshawe Hospital, Manchester M23 9LT, UK
    Thorax 60:17-21. 2005
    ..A study was undertaken to assess the degree of asthma severity (measured by spirometry, airway reactivity and exhaled nitric oxide) in atopic asthmatic patients not sensitised to the domestic allergen to which they were exposed...
  69. ncbi Cellular sources of enhanced brain-derived neurotrophic factor production in a mouse model of allergic inflammation
    A Braun
    Institut für Laboratoriumsmedizin und Pathobiochemie, Charite Campus Virchow Klinikum, Berlin, Germany
    Am J Respir Cell Mol Biol 21:537-46. 1999
    ..In addition, activated alveolar macrophages were identified as BDNF-positive cells. These data indicate that in allergic airway inflammation BDNF production is upregulated and immune cells serve as a source of BDNF...
  70. pmc Fine mapping and positional candidate studies identify HLA-G as an asthma susceptibility gene on chromosome 6p21
    Dan Nicolae
    Department of Statistics, The University of Chicago, Chicago, IL, USA
    Am J Hum Genet 76:349-57. 2005
    ....
  71. ncbi Eosinophilic rhinitis accompanies the development of lower airway inflammation and hyper-reactivity in sensitized mice exposed to aerosolized allergen
    P W Hellings
    Laboratory of Experimental Immunology, Department of Internal Medicine, University Hospitals, Faculty of Medicine, University of Leuven, Herestraat 49, 3000 Leuven, Belgium
    Clin Exp Allergy 31:782-90. 2001
    ..These findings support the viewpoint that upper and lower airway disease represent a continuum of inflammation involving one common airway and provide evidence for the concept of global airway inflammation after inhalation of allergen...
  72. ncbi Emerging airway smooth muscle targets to treat asthma
    Sana Siddiqui
    Meakins Christie Laboratories, Department of Medicine, McGill University, 3626 St Urbain, Montreal, Quebec H2X 2P2, Canada
    Pulm Pharmacol Ther 26:132-44. 2013
    ....
  73. pmc Pirfenidone modulates airway responsiveness, inflammation, and remodeling after repeated challenge
    Atsushi Hirano
    Department of Hematology, Oncology and Respiratory Medicine, Okayama University Graduate School of Medicine and Dentistry, Okayama 700 8558, Japan
    Am J Respir Cell Mol Biol 35:366-77. 2006
    ..These data indicate that pirfenidone may play an important role in the treatment of asthma and has the potential reduce or prevent airway remodeling...
  74. ncbi Lidocaine-derivative JMF2-1 prevents ovalbumin-induced airway inflammation by regulating the function and survival of T cells
    P C Olsen
    Laboratory of Inflammation, Oswaldo Cruz Institute, Oswaldo Cruz Foundation FIOCRUZ, Rio de Janeiro, Brazil
    Clin Exp Allergy 41:250-9. 2011
    ..This prompted further research on the mechanism of action and putative therapeutic application of JMF2-1...
  75. ncbi Persistence of asthma symptoms during adolescence: role of obesity and age at the onset of puberty
    Stefano Guerra
    Arizona Respiratory Center, University of Arizona, 1501 North Campbell Avenue, P O Box 245030, Tucson, AZ 85724 5030, USA
    Am J Respir Crit Care Med 170:78-85. 2004
    ..Our findings from a population-based longitudinal cohort challenge the commonly held view that asthma usually remits during adolescence...
  76. ncbi Mucosal allergic sensitization to cockroach allergens is dependent on proteinase activity and proteinase-activated receptor-2 activation
    Narcy G Arizmendi
    Pulmonary Research Group, Department of Medicine, University of Alberta, Edmonton, Alberta, Canada
    J Immunol 186:3164-72. 2011
    ..We conclude that CE induces PAR(2)-dependent allergic airway sensitization in a mouse model of allergic airway inflammation. PAR(2) activation may be a general mechanism used by aeroallergens to induce allergic sensitization...
  77. pmc S-nitrosoglutathione supplementation to ovalbumin-sensitized and -challenged mice ameliorates methacholine-induced bronchoconstriction
    Matthew W Foster
    Division of Pulmonary, Allergy and Critical Care Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    Am J Physiol Lung Cell Mol Physiol 301:L739-44. 2011
    ..In conclusion, in the OVA mouse model of allergic asthma, aerosolized GSNO has rapid and sustained antibronchoconstrictive effects but does not substantially alter airway inflammation...
  78. ncbi Contribution of antigen-primed CD8+ T cells to the development of airway hyperresponsiveness and inflammation is associated with IL-13
    Nobuaki Miyahara
    Department of Pediatrics, National Jewish Medical and Research Center, Denver, CO 80206, USA
    J Immunol 172:2549-58. 2004
    ..These data suggest that Ag-primed CD8(+) T cells are required for the full development of AHR and airway inflammation, which appears to be associated with IL-13 production from these primed T cells...
  79. ncbi Role of interleukin-13 in eosinophil accumulation and airway remodelling in a mouse model of chronic asthma
    R K Kumar
    Inflammation Research Unit, Department of Pathology, University of New South Wales, Sydney, Australia
    Clin Exp Allergy 32:1104-11. 2002
    ..Interleukin-13 is believed to be important in asthmatic inflammation and airway hyper-reactivity...
  80. pmc Reproducibility of non-specific bronchial challenge in adults: implications for design, analysis and interpretation of clinical and epidemiological studies
    S Chinn
    Department of Public Health Sciences, King s College London, London SE1 3QD, UK
    Thorax 60:395-400. 2005
    ..The intraclass correlation coefficient measures loss of power and degree of bias. Information is lacking on the intraclass correlation coefficient for bronchial responsiveness and factors affecting reproducibility...
  81. ncbi B7-DC regulates asthmatic response by an IFN-gamma-dependent mechanism
    Koichiro Matsumoto
    Research Institute for Diseases of the Chest, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    J Immunol 172:2530-41. 2004
    ..These results suggest a unique role for B7-DC in the regulation of asthmatic response through an IFN-gamma-dependent, but PD-1-independent, mechanism...
  82. ncbi Direct inhibition of arginase attenuated airway allergic reactions and inflammation in a Dermatophagoides farinae-induced NC/Nga mouse model
    Noriko Takahashi
    Department of Public Health, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
    Am J Physiol Lung Cell Mol Physiol 299:L17-24. 2010
    ....
  83. ncbi Identification and association of polymorphisms in the interleukin-13 gene with asthma and atopy in a Dutch population
    T D Howard
    Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Am J Respir Cell Mol Biol 25:377-84. 2001
    ..Further investigation is required to determine which specific alleles or combination of alleles contribute to these phenotypes, and the possible downstream effects of the resulting change in IL-13 levels or activity...
  84. pmc Signal transducer and activator of transcription 6 controls chemokine production and T helper cell type 2 cell trafficking in allergic pulmonary inflammation
    A Mathew
    Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy, and Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    J Exp Med 193:1087-96. 2001
    ..Our findings establish Stat6 as essential for Th2 cell trafficking and effector function and suggest that interruption of Stat6 signaling in resident cells of the lung is a novel approach to asthma therapy...
  85. ncbi Development of murine allergic asthma is dependent upon B7-2 costimulation
    A M Keane-Myers
    Department of Environmental Health Sciences, School of Hygiene and Public Health, Johns Hopkins University, Baltimore, MD 21205, USA
    J Immunol 160:1036-43. 1998
    ..We conclude that B7-2 provides the necessary costimulatory signal required for the development of in vivo allergic responses to inhaled allergen exposure...
  86. pmc Ventilation heterogeneity is a major determinant of airway hyperresponsiveness in asthma, independent of airway inflammation
    Sue R Downie
    Woolcock Institute of Medical Research, Camperdown, NSW 2050, Australia
    Thorax 62:684-9. 2007
    ....
  87. pmc Disruption of antigen-induced airway inflammation and airway hyper-responsiveness in low affinity neurotrophin receptor p75 gene deficient mice
    S Tokuoka
    Department of Pharmacology, Gifu Pharmaceutical University, 5 6 1 Mitahora Higashi, Gifu 502 8585, Japan
    Br J Pharmacol 134:1580-6. 2001
    ..4. The present findings suggest that p75 gene deficiency disrupt an allergic airway inflammation and AHR in mice by interfering type 2 helper T (Th2) cell responses...
  88. ncbi Suppression of the asthmatic phenotype by ultraviolet B-induced, antigen-specific regulatory cells
    J P McGlade
    Telethon Institute for Child Health Research and Centre for Child Health Research, University of Western Australia, Perth, WA, Australia
    Clin Exp Allergy 37:1267-76. 2007
    ....
  89. ncbi Trefoil factor-2 reverses airway remodeling changes in allergic airways disease
    Simon G Royce
    Department of Allergy and Immune Disorders, Murdoch Children s Research Institute Melbourne, Victoria, Australia
    Am J Respir Cell Mol Biol 48:135-44. 2013
    ..However, exogenous TFF2 treatment is effective in reversing aspects of established airway remodeling. TFF2 has potential as a novel treatment for airway remodeling in asthma...
  90. pmc IL-1beta induces murine airway 5-HT2A receptor hyperresponsiveness via a non-transcriptional MAPK-dependent mechanism
    Yaping Zhang
    Laboratory of Clinical and Experimental Allergy Research, Department of Otorhinolaryngology, Malmo University Hospital, Lund University, Malmo, Sweden
    Respir Res 8:29. 2007
    ....
  91. ncbi Changes in airway inflammation following nasal allergic challenge in patients with seasonal rhinitis
    M Bonay
    Unité 700 INSERM, Faculte Xavier Bichat, Paris Cedex, France
    Allergy 61:111-8. 2006
    ..The aim of this study was to analyse the changes induced by allergic nasal challenge outside the pollen season in airway responsiveness and bronchial inflammation of patients with seasonal allergic rhinitis...
  92. ncbi Obesity is a determinant of asthma control independent of inflammation and lung mechanics
    Claude S Farah
    Woolcock Institute of Medical Research, University of Sydney, Camperdown, NSW, 2050, Australia
    Chest 140:659-66. 2011
    ....
  93. pmc Differential immune responses and pulmonary pathophysiology are induced by two different strains of respiratory syncytial virus
    Nicholas W Lukacs
    Department of Pathology, University of Michigan Medical School, 1301 Catherine St, Ann Arbor, MI 48109 0602, USA
    Am J Pathol 169:977-86. 2006
    ..These data demonstrate that different RSV strains of the same antigenic subgroup can elicit differential immune responses that impact the phenotypic expression of RSV-induced illness...
  94. ncbi Airway hyperresponsiveness in the elderly: prevalence and clinical implications
    N Scichilone
    Institute of Respiratory Diseases, University of Palermo, Via Trabucco 180, 90146 Palermo, Italy
    Eur Respir J 25:364-75. 2005
    ..Assessment of airway hyperresponsiveness in the aged should be considered as an additional tool in the diagnostic work-up in the subset of elderly subjects with long-term smoking exposure and/or documented atopy...
  95. ncbi Allogeneic mesenchymal stem cells prevent allergic airway inflammation by inducing murine regulatory T cells
    H Kavanagh
    Cellular Immunology Laboratory, Institute of Immunology, National University of Ireland Maynooth, Maynooth, Co Kildare, Ireland
    Allergy 66:523-31. 2011
    ..MSC induce regulatory T cells (T(reg)) in vitro although the in vivo relevance of this is not clear...
  96. ncbi Comparison of aerosol and intranasal challenge in a mouse model of allergic airway inflammation and hyperresponsiveness
    Linda Swedin
    The National Institute of Environmental Medicine, Division of Physiology, and The Centre for Allergy Research, Karolinska Institutet, Stockholm, Sweden
    Int Arch Allergy Immunol 153:249-58. 2010
    ..Comparisons were made between mice challenged with OVA either as an aerosol or intranasally. The protocol that induced maximal AHR in BALB/c mice was thereafter tested in C57BL/6 mice...
  97. pmc Targeting TNF-alpha: a novel therapeutic approach for asthma
    Christopher Brightling
    Institute of Lung Health, University of Leicester, Leicester, United Kingdom
    J Allergy Clin Immunol 121:5-10; quiz 11-2. 2008
    ..Therefore the challenge for clinicians is to evaluate the risk/benefit ratio of these therapies in individual patients with asthma...
  98. ncbi Bronchial reactivity of healthy subjects: 18-20 h postexposure to ozone
    W M Foster
    Department of Environmental Health Sciences, Johns Hopkins University School of Hygiene and Public Health, Baltimore, Maryland 21205, USA
    J Appl Physiol (1985) 89:1804-10. 2000
    ..These results suggest that bronchial reactivity is significantly altered approximately 1 day after O(3); this injury may contribute to the respiratory morbidity that is observed 1-2 days after an episode of ambient air pollution...
  99. ncbi Methacholine and ovalbumin challenges assessed by forced oscillations and synchrotron lung imaging
    Sam Bayat
    Universite de Picardie Jules Verne, EA4285 Péritox INERIS and CHU Amiens, Amiens, France
    Am J Respir Crit Care Med 180:296-303. 2009
    Methacholine (Mch) is routinely used to assess bronchial hyperreactivity; however, little is known about the differences in the lung response pattern between this provocation and that observed with ovalbumin (Ova) after allergic ..
  100. pmc Reversal of airway hyperresponsiveness by induction of airway mucosal CD4+CD25+ regulatory T cells
    Deborah H Strickland
    Telethon Institute for Child Health Research, and Centre for Child Health Research, Faculty of Medicine and Dentistry, The University of Western Australia, Perth, Western Australia 6008
    J Exp Med 203:2649-60. 2006
    ....
  101. ncbi Interpretation of the "positive" methacholine challenge
    David J Hewitt
    Center for Toxicology and Environmental Health, LLC, North Little Rock, Arkansas
    Am J Ind Med 51:769-81. 2008
    ..asthma, occupational asthma, or reactive airways dysfunction syndrome (RADS) through identification of bronchial hyperreactivity (BHR)...

Research Grants63

  1. An Evaluation of Treatment with Omalizumab to Improve the Asthmatic Response to a
    Thomas A Platts-Mills; Fiscal Year: 2013
    ..possible to directly answer whether anti-IgE treatment is effective in reducing both lung symptoms and bronchial hyperreactivity because it decreases IgE and its receptor on relevant cells, or because it decreases inflammation prior ..
  2. Effects of Reducing Indoor Particulate Matter on the Asthmatic Response
    SONALI BOSE; Fiscal Year: 2013
    ..e. lung function and bronchial hyperreactivity) will be assessed before and after the intervention...
  3. Bronchial Reactivity and the Course of Lung Function After WTC Exposure
    Thomas K Aldrich; Fiscal Year: 2013
    ..There is preliminary evidence that bronchial hyperreactivity is associated with excessive immediate (pre-post 9/11) pulmonary function decline rates, but it remains ..
  4. Eosinophil Granule Proteins and Their Functions
    Gerald Gleich; Fiscal Year: 2006
    ..Further, MBP1 causes bronchial hyperreactivity in monkeys and guinea pigs. We have discovered a novel granule protein, the MBP homologue (MBP2)...
  5. Effects of Vitamin A Deficiency on Virus-Infected Airwa*
    Stephen McGowan; Fiscal Year: 2003
    ..This proposal seeks to address the hypothesis VAD may promote bronchial hyperreactivity (BHR), particularly during and after an upper respiratory infection (URI)...
  6. A MODEL OF BRONCHIAL HYPERREACTIVITY
    N Robinson; Fiscal Year: 1990
    ..overall aim of this research is to investigate a spontaneously occurring model of airway obstruction and bronchial hyperreactivity, two features of human asthma...
  7. PATHOPHYSIOLOGY OF AIRWAY EFFECTS TO COLD EXPOSURE
    EDWARD MCFADDEN; Fiscal Year: 1999
    ..The final trials will describe the spectrum of responses that exist to nasal cold exposure and will determine if they bear any relationship to bronchial hyperreactivity.
  8. Eicosanoids and GPCRs in Airway Physiology
    Beverly Koller; Fiscal Year: 2009
    ..TXA2 is a potent mediator of both bronchoconstriction and bronchial hyperreactivity in humans. The mechanism by which TXA2 mediates these actions is not well understood...
  9. Mechanisms of Eosinophilic Inflammation in Human Asthma
    Hirohito Kita; Fiscal Year: 2005
    Bronchial asthma is characterized by episodic exacerbations of airflow limitation, bronchial hyperreactivity and airway inflammation...
  10. Association between ANP and NPRA Gene Polymorphisms and Severity of Atopy and Ast
    Shyam Mohapatra; Fiscal Year: 2009
    ..g., total serum IgE) and asthma (e.g., bronchial hyperreactivity) phenotypes...
  11. ADHESION MOLECULES IN SMOOTH MUSCLE ACTIVATION & GROWTH
    AILI LAZAAR; Fiscal Year: 2003
    ..Understanding the mechanisms by which CAMs transduce signals that could induce myocyte activation may provide insight in new therapeutic measures to prevent airway inflammation and bronchial hyperreactivity.
  12. ASTHMA AND ALLERGIC DISEASE CENTER GRANT
    William Busse; Fiscal Year: 1992
    ..structure, immune function and the inflammatory response are important to the pathogenesis of bronchial hyperreactivity and asthma...
  13. VIRUS-INDUCIBLE REMODELING OF AIRWAY EPITHELIUM
    MICHAEL HOLTZMAN; Fiscal Year: 2002
    ..proliferation/hyperplasia with striking remodeling/thickening of the airway epithelium and concomitant bronchial hyperreactivity. The airway epithelial remodeling and hyperreactivity persisted for at least a year after the acute ..
  14. LEUKOTRIENE-MEDIATED AIRWAY CHOLINERGIC HYPERRESPONSIVE
    CHRISTOPHER MURLAS; Fiscal Year: 1991
    Increased bronchial irritability (bronchial hyperreactivity) is a characteristic feature of asthma, and understanding its pathogenesis may provide new insights for better treatment...
  15. MUCOSAL GENE TRANSFER IN MURINE AIRWAY ALLERGIC RESPONSE
    Shau Ku Huang; Fiscal Year: 2000
    ..proposal is to determine the role of IFN-gamma in the regulation of Ag-induced airway inflammation and bronchial hyperreactivity by gene transfer of IFN-gamma directly into lung mucosal cells...
  16. Functional implications of the TNF
    W Michael Foster; Fiscal Year: 2009
    ..response that is characterized by increases in epithelial permeability, neutrophil infiltration, and bronchial hyperreactivity. Inhalation of the pleiotropic pro-inflammatory cytokine tumor necrosis factor (TNF) leads to the ..
  17. IGE MEDIATED BRONCHIAL RESPONSES TO ALLERGEN
    Hans Oettgen; Fiscal Year: 1999
    ..inflammation of the bronchial mucosa and display two distinct physiologic responses of the airways: bronchial hyperreactivity to nonspecific stimuli (BHR) and acute allergen-induced airflow obstruction following inhalation of ..
  18. PULMONARY C-NEURON HYPERSENSITIVITY:CELLULAR MECHANISMS
    Lu Yuan Lee; Fiscal Year: 2005
    The long-range goal of this research project is to understand the neurogenic mechanisms underlying the bronchial hyperreactivity caused by inflammation of airway mucosa...
  19. Role of EGFR in Viral Infected Lung Epithelial Cells
    Martha M Monick; Fiscal Year: 2010
    ..changes in the airways (20-35% of infants with serious RSV infections go on to develop increased bronchial hyperreactivity). This application addresses the role of EGFR in modulating RSV-induced inflammation and apoptosis...
  20. Assessment of Lung function in Mice
    Jason Bates; Fiscal Year: 2009
    ....
  21. Chemogenomics to Identify New Molecular Targets in PF
    William Henderson; Fiscal Year: 2006
    ..These studies represent a focused effort using chemogenomics to identify, develop, and validate small molecule inhibitors of AP-1/TGFBeta-driven profibrotic gene expression as novel therapies in PF patients. ..
  22. MECHANICS OF ACUTE LUNG INJURY
    Jason Bates; Fiscal Year: 2009
    ..The results of our studies are expected to lead to the design of physiologically-based lung recruitment strategies that can be tailored to the individual patient with ALI. This will set the stage for future clinical trials. ..
  23. 5-LIPOXYGENASE PRODUCTS IN ASTHMATIC IMMUNE RESPONSE
    William Henderson; Fiscal Year: 2008
    ..abstract_text> ..
  24. Early Life Exposure to Microbial Products and Asthma
    Joel Kline; Fiscal Year: 2005
    ..Question 2A: What mediators promote immune tolerance induced by early life exposure to microbial products? Question 2B: What cells are responsible for immune tolerance induced by early life exposure to microbial products? ..
  25. Helminth-Induced Immune Tolerance in Asthma
    Joel Kline; Fiscal Year: 2005
    ..Although completion of the second Aim is almost certainly beyond the scope of this two-year developmental research grant, these studies will be continued and extended through an R01 grant application. ..
  26. Innovative Investigations and Therapies for Asthma
    Richard Martin; Fiscal Year: 2007
    ..The ability to predict who will and will not respond to corticosteroids and additive therapy will greatly improve our ability to treat asthma effectively. ..
  27. The Effect of Mycoplasma on Chronic Asthma
    Richard Martin; Fiscal Year: 2008
    ..pneumoniae and asthma will be obtained through this PPG and will ultimately give new knowledge to the understanding of asthma pathophysiology and potential future novel therapies. ..
  28. ASTHMA CHRONOBIOLOGY: CENTRAL AND LUNG INTERACTIONS
    Richard Martin; Fiscal Year: 2003
    ....
  29. ASTHMA CLINICAL RESEARCH NETWORK (ACRN)
    Richard Martin; Fiscal Year: 2002
    ....
  30. Induction of Respiratory Tolerance By Mucosal CpG ODN
    Joel Kline; Fiscal Year: 2006
    ..Aim 2: To evaluate whether anti-inflammatory effects of airway mucosal exposure to CpG-ODN are mediated through regulatory T-lymphocytes. ..
  31. Fine mapping of an Asthma Locus of Chromosome 12q
    Benjamin Raby; Fiscal Year: 2007
    ..Identification of these variants may have a significant impact on the public health of asthma patients. ..
  32. Severe Asthma From Respiratory Infections
    William W Busse; Fiscal Year: 2010
    ..These studies will provide new insights into the mechanisms of asthma, particularly severe disease, and possibilities of new approaches to treatment. ..
  33. GENETIC, BIOLOGIC, & IMMUNOLOGIC DETERMINANTS OF ASTHMA
    Mario Castro; Fiscal Year: 2006
    ..abstract_text> ..
  34. Role of cockroach proteases in airway inflammation
    Kristen Page; Fiscal Year: 2009
    ..Finally, we will investigate the role of endogenous TNF alpha in the airways using a TNF alpha neutralizing antibody and TNF alpha knockout mice. ..
  35. Role of TGF-Alpha in Pulmonary Vascular Disease
    TIMOTHY LE CRAS; Fiscal Year: 2006
    ..This information will serve as a basis for developing therapeutic strategies aimed at improving lung growth and preventing pulmonary hypertension in premature babies and adults. ..
  36. The Genetic Epidemiology of Asthma in Costa Rica
    Scott Weiss; Fiscal Year: 2005
    ..Thus, this proposal will greatly contribute to our understanding of the pathogenesis of a significant public health problem among Hispanic Americans: bronchial asthma. ..
  37. Eosinophil Trafficking
    David Broide; Fiscal Year: 2005
    ..Overall, these studies should improve our understanding of the molecular mechanism of eosinophil recruitment in vivo and its effect on airway structure and function. ..
  38. DIET, IMMUNE MODULATION, AND ASTHMA IN EARLY LIFE
    Scott Weiss; Fiscal Year: 2002
    ....
  39. Obesity, Inflammation and Response to Therapy in Asthma
    EVERETT RAND SUTHERLAND; Fiscal Year: 2010
    ..End of Abstract) ..
  40. Regulation of Inflammation in Asthma by Fas Ligand
    Angela Haczku; Fiscal Year: 2009
    ..Finally, in order to help support the hypothesis that pro-apoptotic FasL activity characterized in human airway cells is truly physiologic, we will perform challenge studies in mice under FasL neutralizing conditions. ..
  41. Epidemiology of asthma: risk and prognosis in a cohort from birth to adolescence
    Syed Hasan Arshad; Fiscal Year: 2010
    ..Our work brings together a multidisciplinary research team with a proven record of collaboration and expertise in respiratory medicine, allergy and immunology, epidemiology, genetics, and biostatistics. ..
  42. Organophosphates Modify Eosinophil and Nerve Interaction
    Becky Proskocil; Fiscal Year: 2008
    ..The observed effects of OPs on eosinophils and nerves will be measured in isolated cells. [unreadable] [unreadable] [unreadable]..
  43. MECHANISMS OF RHINOVIRUS INDUCED ASTHMA
    William Busse; Fiscal Year: 2002
    ..The proposed studies will provide new evidence as the mechanisms by which RV-infected epithelial cells cause granulocytic bronchial inflammation and asthma exacerbations. ..
  44. Chemokine Blockade to Preserve Lung Development
    Richard Auten; Fiscal Year: 2005
    ..Aim 3 will determine whether blockade of leukocyte function can safely preserve normal alveolar development during recovery from severe oxidant stress. ..
  45. Surfactant-Protein Innate Immunity in an Asthma Model
    Angela Haczku; Fiscal Year: 2008
    ..The potential opportunity to interfere with allergic sensitization by SP-D treatment bears high clinical significance. [unreadable] [unreadable]..
  46. ADMINISTRATIVE/EDUCATION CENTER FOR INNATE IMMUNITY PGA
    Scott Weiss; Fiscal Year: 2004
    ..abstract_text> ..
  47. ENDOTHELIUM--SIGNALING FROM MAST CELLS TO EOSINOPHILS
    David Broide; Fiscal Year: 2002
    ....
  48. Biomarkers in sputum in COPD
    David Broide; Fiscal Year: 2005
    ..abstract_text> ..
  49. Airway Remodeling in Severe Asthma
    Mario Castro; Fiscal Year: 2005
    ..The identification of the potential variables associated with remodeling and severe asthma will help identify individuals at risk who would benefit from specific targeted therapy. ..
  50. Asthma Clinical Research Network-Washington University
    Mario Castro; Fiscal Year: 2007
    ..We propose that it is only through such a collaboration that important questions regarding current and novel therapies and management of asthma can be answered. ..
  51. RSV AND ASTHMA
    David Broide; Fiscal Year: 2003
    ..Adenovirus (not CpG suppressed) to assess Th1 versus Th2 responses, eosinophilic airway inflammation and bronchial hyperreactivity. Additional experiments will determine which DNA based vaccine strategy (ISS alone, DNA-RSV-F alone, or ..
  52. REGULATION OF MUCIN GENE EXPRESSION BY ELASTASE
    Judith Voynow; Fiscal Year: 2003
    ..The ultimate goal is to use information from this project to identify new biologic targets for therapeutic interventions to prevent mucus obstruction in chronic inflammatory airway diseases. ..
  53. Extracellular Matrix Synthesis and Turnover in Asthma
    Mark A Aronica; Fiscal Year: 2010
    ....
  54. AIRWAY FIBROSIS, LUNG MECHANICS, AND HYPERRESPONSIVENESS
    Charles Irvin; Fiscal Year: 2001
    ..The results should provide rationales for new and novel approaches to the treatment of severe and progressive asthma. ..
  55. RESPIRATORY SYNCYTIAL VIRUS ON ALLERGIC AIRWAY DISEASE
    R Peebles; Fiscal Year: 2003
    ....
  56. GENETIC REGULATION OF 03-INDUCED INFLAMMATION
    W Foster; Fiscal Year: 2003
    ..abstract_text> ..
  57. Molecular Regulation of Primary Dendritogenesis
    Pamela Lein; Fiscal Year: 2005
    ..abstract_text> ..
  58. Native LDL, Cholesterol and Impaired Vasodilation
    Kirkwood Pritchard; Fiscal Year: 2006
    ..Investigations in to how 4F protects vascular function will provide new understanding of the mechanisms by which LDL impairs vasodilation and HDL protects vascular function. ..
  59. Epidemiology of Regulatory T Cells in Pregnancy and Childhood Atopic Diseases
    Ganesa Wegienka; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  60. Mechanisms by which Influenza A Protects Against Asthma
    DALE UMETSU; Fiscal Year: 2008
    ..We will also learn more about regulatory mechanisms that affect airway inflammation, and how viral infections and the environment affect the development of asthma. ..
  61. CysLt and P2Y Receptors and Lung Inflammation
    Joshua Boyce; Fiscal Year: 2007
    ..abstract_text> ..
  62. Study of Genetics, Endotoxin and Allergen (SAGE)
    Karin Pacheco; Fiscal Year: 2007
    ....
  63. AUTONOMIC REGULATION OF AIRWAY SMOOTH MUSCLE TONE
    BRENDAN CANNING; Fiscal Year: 2001
    ..It is anticipated that this information will improve our understanding of the role of the autonomic innervation of the healthy and diseased lung. ..