asthma

Summary

Summary: A form of bronchial disorder associated with airway obstruction, marked by recurrent attacks of paroxysmal dyspnea, with wheezing due to spasmodic contraction of the bronchi.

Top Publications

  1. ncbi Worldwide time trends in the prevalence of symptoms of asthma, allergic rhinoconjunctivitis, and eczema in childhood: ISAAC Phases One and Three repeat multicountry cross-sectional surveys
    M Innes Asher
    Department of Paediatrics, Faculty of Medical and Health Sciences, University of Auckland, Auckland 1010, New Zealand
    Lancet 368:733-43. 2006
  2. doi Global strategy for asthma management and prevention: GINA executive summary
    E D Bateman
    University of Cape Town Lung Institute, PO Box 34560, Groote School, 7700 Mowbray, Cape Town, South Africa
    Eur Respir J 31:143-78. 2008
  3. pmc A large-scale, consortium-based genomewide association study of asthma
    Miriam F Moffatt
    National Heart and Lung Institute, Imperial College, London, United Kingdom
    N Engl J Med 363:1211-21. 2010
  4. ncbi The global burden of asthma: executive summary of the GINA Dissemination Committee report
    Matthew Masoli
    Allergy 59:469-78. 2004
  5. doi Allergic Rhinitis and its Impact on Asthma (ARIA) 2008 update (in collaboration with the World Health Organization, GA(2)LEN and AllerGen)
    J Bousquet
    University Hospital and INSERM, Hopital Arnaud de Villeneuve, Montpellier, France
    Allergy 63:8-160. 2008
  6. ncbi Systematic review and meta-analysis of the association between {beta}2-adrenoceptor polymorphisms and asthma: a HuGE review
    Ammarin Thakkinstian
    Clinical Epidemiology Unit, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand
    Am J Epidemiol 162:201-11. 2005
  7. doi Asthma phenotypes: the evolution from clinical to molecular approaches
    Sally E Wenzel
    University of Pittsburgh Asthma Institute at UPMC and the University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Nat Med 18:716-25. 2012
  8. ncbi Genetic variants regulating ORMDL3 expression contribute to the risk of childhood asthma
    Miriam F Moffatt
    National Heart and Lung Institute, Imperial College, London SW3 6LY, UK
    Nature 448:470-3. 2007
  9. ncbi Interleukin-13: central mediator of allergic asthma
    M Wills-Karp
    Department of Environmental Health Sciences, Johns Hopkins University School of Hygiene and Public Health, Baltimore, MD 21205, USA
    Science 282:2258-61. 1998
  10. pmc Mepolizumab and exacerbations of refractory eosinophilic asthma
    Pranabashis Haldar
    Institute for Lung Health, Glenfield Hospital, University Hospitals of Leicester National Health Service Trust, Leicester, United Kingdom
    N Engl J Med 360:973-84. 2009

Detail Information

Publications281 found, 100 shown here

  1. ncbi Worldwide time trends in the prevalence of symptoms of asthma, allergic rhinoconjunctivitis, and eczema in childhood: ISAAC Phases One and Three repeat multicountry cross-sectional surveys
    M Innes Asher
    Department of Paediatrics, Faculty of Medical and Health Sciences, University of Auckland, Auckland 1010, New Zealand
    Lancet 368:733-43. 2006
    Data for trends in prevalence of asthma, allergic rhinoconjunctivitis, and eczema over time are scarce...
  2. doi Global strategy for asthma management and prevention: GINA executive summary
    E D Bateman
    University of Cape Town Lung Institute, PO Box 34560, Groote School, 7700 Mowbray, Cape Town, South Africa
    Eur Respir J 31:143-78. 2008
    b>Asthma is a serious health problem throughout the world. During the past two decades, many scientific advances have improved our understanding of asthma and ability to manage and control it effectively...
  3. pmc A large-scale, consortium-based genomewide association study of asthma
    Miriam F Moffatt
    National Heart and Lung Institute, Imperial College, London, United Kingdom
    N Engl J Med 363:1211-21. 2010
    Susceptibility to asthma is influenced by genes and environment; implicated genes may indicate pathways for therapeutic intervention...
  4. ncbi The global burden of asthma: executive summary of the GINA Dissemination Committee report
    Matthew Masoli
    Allergy 59:469-78. 2004
  5. doi Allergic Rhinitis and its Impact on Asthma (ARIA) 2008 update (in collaboration with the World Health Organization, GA(2)LEN and AllerGen)
    J Bousquet
    University Hospital and INSERM, Hopital Arnaud de Villeneuve, Montpellier, France
    Allergy 63:8-160. 2008
  6. ncbi Systematic review and meta-analysis of the association between {beta}2-adrenoceptor polymorphisms and asthma: a HuGE review
    Ammarin Thakkinstian
    Clinical Epidemiology Unit, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand
    Am J Epidemiol 162:201-11. 2005
    ..investigated two common polymorphisms in the beta(2)-adrenoceptor gene, Arg/Gly16 and Gln/Glu27, in relation to asthma susceptibility...
  7. doi Asthma phenotypes: the evolution from clinical to molecular approaches
    Sally E Wenzel
    University of Pittsburgh Asthma Institute at UPMC and the University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Nat Med 18:716-25. 2012
    Although asthma has been considered as a single disease for years, recent studies have increasingly focused on its heterogeneity...
  8. ncbi Genetic variants regulating ORMDL3 expression contribute to the risk of childhood asthma
    Miriam F Moffatt
    National Heart and Lung Institute, Imperial College, London SW3 6LY, UK
    Nature 448:470-3. 2007
    b>Asthma is caused by a combination of poorly understood genetic and environmental factors...
  9. ncbi Interleukin-13: central mediator of allergic asthma
    M Wills-Karp
    Department of Environmental Health Sciences, Johns Hopkins University School of Hygiene and Public Health, Baltimore, MD 21205, USA
    Science 282:2258-61. 1998
    The worldwide incidence, morbidity, and mortality of allergic asthma are increasing...
  10. pmc Mepolizumab and exacerbations of refractory eosinophilic asthma
    Pranabashis Haldar
    Institute for Lung Health, Glenfield Hospital, University Hospitals of Leicester National Health Service Trust, Leicester, United Kingdom
    N Engl J Med 360:973-84. 2009
    Exacerbations of asthma are associated with substantial morbidity and mortality and with considerable use of health care resources. Preventing exacerbations remains an important goal of therapy...
  11. doi Prenatal and passive smoke exposure and incidence of asthma and wheeze: systematic review and meta-analysis
    Hannah Burke
    Division of Epidemiology and Public Health, University of Nottingham, City Hospital, UK Centre for Tobacco Control Studies, Nottingham, UK
    Pediatrics 129:735-44. 2012
    Exposure to passive smoke is a common and avoidable risk factor for wheeze and asthma in children...
  12. doi The airway epithelium in asthma
    Bart N Lambrecht
    Laboratory of Immunoregulation and Mucosal Immunology, Department of Molecular Biomedical Research, VIB, Ghent, Belgium
    Nat Med 18:684-92. 2012
    b>Asthma is a T lymphocyte-controlled disease of the airway wall caused by inflammation, overproduction of mucus and airway wall remodeling leading to bronchial hyperreactivity and airway obstruction...
  13. doi Lebrikizumab treatment in adults with asthma
    Jonathan Corren
    Allergy Medical Clinic, Los Angeles, California, USA
    N Engl J Med 365:1088-98. 2011
    Many patients with asthma have uncontrolled disease despite treatment with inhaled glucocorticoids...
  14. pmc Meta-analysis of genome-wide association studies of asthma in ethnically diverse North American populations
    Dara G Torgerson
    Department of Human Genetics, University of Chicago, Chicago, Illinois, USA
    Nat Genet 43:887-92. 2011
    b>Asthma is a common disease with a complex risk architecture including both genetic and environmental factors...
  15. ncbi Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis
    Colin N A Palmer
    Population Pharmacogenetics Group, Biomedical Research Centre, University of Dundee, Ninewells Hospital and Medical School, Dundee DD1 9SY, UK
    Nat Genet 38:441-6. 2006
    Atopic disease, including atopic dermatitis (eczema), allergy and asthma, has increased in frequency in recent decades and now affects approximately 20% of the population in the developed world...
  16. pmc House dust mite allergen induces asthma via Toll-like receptor 4 triggering of airway structural cells
    Hamida Hammad
    Laboratory of Immunoregulation and Mucosal Immunology, Department of Respiratory Medicine, Ghent University, Ghent, Belgium
    Nat Med 15:410-6. 2009
    ..Finally, inhalation of a TLR4 antagonist to target exposed epithelial cells suppressed the salient features of asthma, including bronchial hyperreactivity...
  17. pmc The many paths to asthma: phenotype shaped by innate and adaptive immunity
    Hye Young Kim
    Division of Immunology and Allergy, Children s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Nat Immunol 11:577-84. 2010
    b>Asthma is a very complex and heterogeneous disease that is characterized by airway inflammation and airway hyper-reactivity (AHR)...
  18. ncbi Development of the asthma control test: a survey for assessing asthma control
    Robert A Nathan
    Asthma and allergy Associates and Research Center, Colorado Springs, USA
    J Allergy Clin Immunol 113:59-65. 2004
    b>Asthma guidelines indicate that the goal of treatment should be optimum asthma control...
  19. pmc Disordered microbial communities in asthmatic airways
    Markus Hilty
    National Heart and Lung Institute, Imperial College London, London, England
    PLoS ONE 5:e8578. 2010
    A rich microbial environment in infancy protects against asthma [1], [2] and infections precipitate asthma exacerbations [3]...
  20. ncbi Atopic dermatitis and the atopic march
    Jonathan M Spergel
    Division of Allergy and Immunology, The Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    J Allergy Clin Immunol 112:S118-27. 2003
    ..in the United States, Europe, and Japan and is increasing, similar to that of other atopic disorders, particularly asthma. AD has been classified into 3 sequential phases: infantile, childhood, and adult, each with characteristic ..
  21. doi Chronic obstructive pulmonary disease in non-smokers
    Sundeep S Salvi
    Chest Research Foundation, Pune, India
    Lancet 374:733-43. 2009
    ..the association of COPD with biomass fuel, occupational exposure to dusts and gases, history of pulmonary tuberculosis, chronic asthma, respiratory-tract infections during childhood, outdoor air pollution, and poor socioeconomic status.
  22. pmc Global asthma prevalence in adults: findings from the cross-sectional world health survey
    Teresa To
    Child Health Evaluative Sciences, The Hospital for Sick Children, Toronto, Ontario, Canada
    BMC Public Health 12:204. 2012
    b>Asthma is a major cause of disability, health resource utilization and poor quality of life world-wide...
  23. doi Nutrients and foods for the primary prevention of asthma and allergy: systematic review and meta-analysis
    Ulugbek Nurmatov
    Allergy and Respiratory Research Group Centre for Population Health Sciences, University of Edinburgh, Medical School, Edinburgh, United Kingdom
    J Allergy Clin Immunol 127:724-33.e1-30. 2011
    Epidemiologic studies suggest that deficiencies of the nutrients selenium; zinc; vitamins A, C, D, and E; and low fruit and vegetable intake may be associated with the development of asthma and allergic disorders.
  24. pmc Genome-wide association study identifies three new susceptibility loci for adult asthma in the Japanese population
    Tomomitsu Hirota
    Laboratory for Respiratory Diseases, Center for Genomic Medicine, RIKEN, Yokohama, Kanagawa, Japan
    Nat Genet 43:893-6. 2011
    Bronchial asthma is a common inflammatory disease caused by the interaction of genetic and environmental factors...
  25. doi Exposure to environmental microorganisms and childhood asthma
    Markus J Ege
    University Children s Hospital Munich, Munich, Germany
    N Engl J Med 364:701-9. 2011
    ..that afford them a wide range of microbial exposures, such as traditional farms, are protected from childhood asthma and atopy. In previous studies, markers of microbial exposure have been inversely related to these conditions.
  26. pmc Lung eQTLs to help reveal the molecular underpinnings of asthma
    Ke Hao
    Merck Research Laboratories, Boston, Massachusetts, United States of America
    PLoS Genet 8:e1003029. 2012
    ..to discover genetic variants affecting gene expression in human lung tissue, to refine susceptibility loci for asthma identified in GWAS studies, and to use the genetics of gene expression and network analyses to find key molecular ..
  27. pmc The clinical features of the overlap between COPD and asthma
    Megan Hardin
    Channing Laboratory, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Respir Res 12:127. 2011
    The coexistence of COPD and asthma is widely recognized but has not been well described. This study characterizes clinical features, spirometry, and chest CT scans of smoking subjects with both COPD and asthma.
  28. ncbi IL-17 is increased in asthmatic airways and induces human bronchial fibroblasts to produce cytokines
    S Molet
    Meakins-Christie Laboratories, McGill University, Montreal, Canada
    J Allergy Clin Immunol 108:430-8. 2001
    ..cells positive for IL-17 are significantly increased in sputum and bronchoalveolar lavage fluids of subjects with asthma in comparison with control subjects (P <.001 and P <.005, respectively)...
  29. ncbi The asthma epidemic
    Waltraud Eder
    University Children s Hospital, Munich, Germany
    N Engl J Med 355:2226-35. 2006
  30. doi The sentinel role of the airway epithelium in asthma pathogenesis
    Stephen T Holgate
    Allergy and Inflammation Research, Division of Infection, Inflammation and Immunity, School of Medicine, Southampton University and General Hospital, Southampton, Hampshire, UK
    Immunol Rev 242:205-19. 2011
    The adoption of the concept that asthma is primarily a disease most frequently associated with elaboration of T-helper 2 (Th2)-type inflammation has led to the widely held concept that its origins, exacerbation, and persistence are ..
  31. doi Effect of bronchoconstriction on airway remodeling in asthma
    Christopher L Grainge
    Division of Infection, Inflammation and Immunity, University of Southampton School of Medicine, Southampton, United Kingdom
    N Engl J Med 364:2006-15. 2011
    b>Asthma is characterized pathologically by structural changes in the airway, termed airway remodeling. These changes are associated with worse long-term clinical outcomes and have been attributed to eosinophilic inflammation...
  32. doi An unexpected role for uric acid as an inducer of T helper 2 cell immunity to inhaled antigens and inflammatory mediator of allergic asthma
    Mirjam Kool
    Laboratory of Immunoregulation and Mucosal Immunology, Department of Respiratory Diseases, University Ghent, Ghent 9000, Belgium
    Immunity 34:527-40. 2011
    ..of UA crystals together with protein antigen was sufficient to promote Th2 cell immunity and features of asthma. The adjuvant effects of UA did not require the inflammasome (Nlrp3, Pycard) or the interleukin-1 (Myd88, IL-1r) ..
  33. doi The association between obesity and asthma: interactions between systemic and airway inflammation
    Tim J T Sutherland
    Respiratory Research Unit, Department of Medical and Surgical Sciences, Dunedin School of Medicine, University of Otago, Dunedin, New Zealand
    Am J Respir Crit Care Med 178:469-75. 2008
    Both obesity and asthma are common conditions, and both are characterized by the presence of inflammation. Animal studies suggest that the development of airway hyperresponsiveness with antigen challenge is exaggerated with obesity...
  34. doi Innate IL-13-producing nuocytes arise during allergic lung inflammation and contribute to airways hyperreactivity
    Jillian L Barlow
    MRC Laboratory of Molecular Biology, Cambridge, United Kingdom
    J Allergy Clin Immunol 129:191-8.e1-4. 2012
    ..Previous work supposed that the essential source of these cytokines was CD4(+) T(H)2 cells. However, more recent studies have suggested that other innate production of type 2 cytokines might be as important...
  35. pmc Pulmonary expression of interleukin-13 causes inflammation, mucus hypersecretion, subepithelial fibrosis, physiologic abnormalities, and eotaxin production
    Z Zhu
    Section of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06520 8057, USA
    J Clin Invest 103:779-88. 1999
    ..IL-13 may play an important role in the pathogenesis of similar responses in asthma or other Th2-polarized tissue responses.
  36. ncbi The global burden of asthma
    Sidney S Braman
    Brown University, Rhode Island Hospital, Division of Pulmonary and Critical Care Medicine, 593 Eddy St, Providence, RI 02903 4923, USA
    Chest 130:4S-12S. 2006
    There has been a sharp increase in the global prevalence, morbidity, mortality, and economic burden associated with asthma over the last 40 years, particularly in children...
  37. doi Mepolizumab for severe eosinophilic asthma (DREAM): a multicentre, double-blind, placebo-controlled trial
    Ian D Pavord
    Institute for Lung Health, University Hospitals of Leicester NHS Trust, Glenfield Hospital, Leicester, UK
    Lancet 380:651-9. 2012
    Some patients with severe asthma have recurrent asthma exacerbations associated with eosinophilic airway inflammation...
  38. doi Allergic Rhinitis and its Impact on Asthma (ARIA): achievements in 10 years and future needs
    J Bousquet
    J Allergy Clin Immunol 130:1049-62. 2012
    Allergic rhinitis (AR) and asthma represent global health problems for all age groups. Asthma and rhinitis frequently coexist in the same subjects...
  39. pmc Analyses of asthma severity phenotypes and inflammatory proteins in subjects stratified by sputum granulocytes
    Annette T Hastie
    Center for Human Genomics, Wake Forest University Health Sciences, Winston Salem, NC 27157, USA
    J Allergy Clin Immunol 125:1028-1036.e13. 2010
    Patients with severe asthma have increased granulocytes in their sputum compared with patients with mild to moderate asthma.
  40. pmc Requirement for IL-13 independently of IL-4 in experimental asthma
    G Grunig
    Department of Medicine, San Francisco General Hospital, University of California San Francisco, San Francisco, CA 94143, USA
    Science 282:2261-3. 1998
    The pathogenesis of asthma reflects, in part, the activity of T cell cytokines. Murine models support participation of interleukin-4 (IL-4) and the IL-4 receptor in asthma...
  41. pmc Worldwide trends in the prevalence of asthma symptoms: phase III of the International Study of Asthma and Allergies in Childhood (ISAAC)
    Neil Pearce
    Centre for Public Health Research, Massey University Wellington Campus, Private Box 756, Wellington, New Zealand
    Thorax 62:758-66. 2007
    Phase I of the International Study of Asthma and Allergies in Childhood (ISAAC) was designed to allow worldwide comparisons of the prevalence of asthma symptoms...
  42. doi Mepolizumab for prednisone-dependent asthma with sputum eosinophilia
    Parameswaran Nair
    Firestone Institute for Respiratory Health, St Joseph s Healthcare and Department of Medicine, McMaster University, Hamilton, ON, Canada
    N Engl J Med 360:985-93. 2009
    ..inflammation, which may be a consequence of interleukin-5 action, is a characteristic feature of some forms of asthma. However, in three previous clinical trials involving patients with asthma, blockade of this cytokine did not ..
  43. ncbi Leukotrienes
    Marc Peters-Golden
    Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan Health System, Ann Arbor 48109 5642, USA
    N Engl J Med 357:1841-54. 2007
  44. doi Glucocorticoid resistance in inflammatory diseases
    Peter J Barnes
    National Heart and Lung Institute, Imperial College, London, UK
    Lancet 373:1905-17. 2009
    ..obstructive pulmonary disease and acute respiratory distress syndrome; it is also an issue for some patients with asthma, rheumatoid arthritis, and inflammatory bowel disease...
  45. pmc Asthmatic bronchial epithelial cells have a deficient innate immune response to infection with rhinovirus
    Peter A B Wark
    The Brooke Laboratories, University of Southampton, Southampton SO16 6YD, UK
    J Exp Med 201:937-47. 2005
    Rhinoviruses are the major trigger of acute asthma exacerbations and asthmatic subjects are more susceptible to these infections...
  46. ncbi Is vitamin D deficiency to blame for the asthma epidemic?
    Augusto A Litonjua
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, MA, USA
    J Allergy Clin Immunol 120:1031-5. 2007
    In the 1960s, the prevalence of asthma and allergic diseases began to increase worldwide. Currently, the burden of the disease is more than 300 million people affected...
  47. ncbi Mast-cell infiltration of airway smooth muscle in asthma
    Christopher E Brightling
    Division of Respiratory Medicine, Institute for Lung Health, Leicester Warwick Medical School and University Hospitals of Leicester, Leicester, United Kingdom
    N Engl J Med 346:1699-705. 2002
    b>Asthma and eosinophilic bronchitis are characterized by similar inflammatory infiltrates in the submucosa of the lower airway...
  48. doi Immunology of asthma and chronic obstructive pulmonary disease
    Peter J Barnes
    Airway Disease Section, National Heart and Lung Institute, Imperial College London, Dovehouse Street, London SW3 6LY, UK
    Nat Rev Immunol 8:183-92. 2008
    b>Asthma and chronic obstructive pulmonary disease (COPD) are both obstructive airway diseases that involve chronic inflammation of the respiratory tract, but the type of inflammation is markedly different between these diseases, with ..
  49. doi Allergic Rhinitis and its Impact on Asthma (ARIA) guidelines: 2010 revision
    Jan L Brozek
    Department of Clinical Epidemiology and Biostatistics and Medicine, McMaster University, Hamilton, Ontario, Canada
    J Allergy Clin Immunol 126:466-76. 2010
    ..The Allergic Rhinitis and its Impact on Asthma (ARIA) guidelines have been widely used to treat the approximately 500 million affected patients globally.
  50. doi Uniform definition of asthma severity, control, and exacerbations: document presented for the World Health Organization Consultation on Severe Asthma
    Jean Bousquet
    University Hospital, Hopital Arnaud de Villeneuve, Montpellier, France
    J Allergy Clin Immunol 126:926-38. 2010
    b>Asthma is a global health problem affecting around 300 million individuals of all ages, ethnic groups and countries. It is estimated that around 250,000 people die prematurely each year as a result of asthma...
  51. pmc Association between serum 25-hydroxyvitamin D level and upper respiratory tract infection in the Third National Health and Nutrition Examination Survey
    Adit A Ginde
    Emergency Medicine Network, Massachusetts General Hospital, 326 Cambridge Street, Boston, MA 02114, USA
    Arch Intern Med 169:384-90. 2009
    ..We hypothesize that serum 25-hydroxyvitamin D (25[OH]D) levels are inversely associated with self-reported recent upper RTI (URTI)...
  52. pmc Role of viral respiratory infections in asthma and asthma exacerbations
    William W Busse
    Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA
    Lancet 376:826-34. 2010
    Viral respiratory tract infections are common and usually selflimited illnesses. For patients at risk of asthma, or with existing asthma, viral respiratory tract infections can have a profound effect on the expression of disease or loss ..
  53. doi IgE in allergy and asthma today
    Hannah J Gould
    Randall Division of Cell and Molecular Biophysics, and MRC and Asthma UK Centre in Allergic Mechanisms of Asthma, King s College London, New Hunt s House, Guy s Campus, London, SE1 1UL, UK
    Nat Rev Immunol 8:205-17. 2008
    The spreading epidemic of allergies and asthma has heightened interest in IgE, the central player in the allergic response...
  54. doi Is the prevalence of asthma declining? Systematic review of epidemiological studies
    C Anandan
    Centre for Population Health Sciences, University of Edinburgh, UK
    Allergy 65:152-67. 2010
    b>Asthma prevalence has increased very considerably in recent decades such that it is now one of the commonest chronic disorders in the world...
  55. ncbi Patients' beliefs about prescribed medicines and their role in adherence to treatment in chronic physical illness
    R Horne
    Centre for Health Care Reserach, University of Brighton, UK
    J Psychosom Res 47:555-67. 1999
    ..to assess relations between beliefs and reported adherence among 324 patients from four chronic illness groups (asthma, renal, cardiac, and oncology)...
  56. doi Trends in the prevalence of asthma and allergic rhinitis in Italy between 1991 and 2010
    R de Marco
    Unit of Epidemiology and Medical Statistics, Dept of Public Health and Community Health, University of Verona, 37134 Verona, Italy
    Eur Respir J 39:883-92. 2012
    The prevalence of asthma increased worldwide until the 1990s, but since then there has been no clear temporal pattern...
  57. doi Interleukin-17A induces glucocorticoid insensitivity in human bronchial epithelial cells
    G J Zijlstra
    Laboratory of Allergology and Pulmonary Diseases Dept of Pathology and Medical Biology GRIAC Research Institute University Medical Center Groningen, University of Groningen, PO Box 30001, 9700 RB Groningen, The Netherlands
    Eur Respir J 39:439-45. 2012
    A subset of asthma patients suffer from glucocorticoid (GC) insensitivity. T-helper cell type 17 cells have an emerging role in GC insensitivity, although the mechanisms are still poorly understood...
  58. pmc Clinical effects of home telemonitoring in the context of diabetes, asthma, heart failure and hypertension: a systematic review
    Guy Paré
    HEC Montreal, Montreal, Canada
    J Med Internet Res 12:e21. 2010
    ..Home telemonitoring figures among the various solutions that could help attenuate some of the problems associated with aging populations, rates of chronic illness, and shortages of health professionals...
  59. pmc Inflammatory dendritic cells--not basophils--are necessary and sufficient for induction of Th2 immunity to inhaled house dust mite allergen
    Hamida Hammad
    Laboratory of Immunoregulation and Mucosal Immunology, Department of Respiratory Diseases, University of Ghent, 9000 Ghent, Belgium
    J Exp Med 207:2097-111. 2010
    ..Inflammatory DCs were necessary and sufficient for induction of Th2 immunity and features of asthma, whereas basophils were not required...
  60. pmc Wheezing rhinovirus illnesses in early life predict asthma development in high-risk children
    Daniel J Jackson
    Department of Pediatrics, University of Wisconsin Madison, Madison, WI, USA
    Am J Respir Crit Care Med 178:667-72. 2008
    Virus-induced wheezing episodes in infancy often precede the development of asthma. Whether infections with specific viral pathogens confer differential future asthma risk is incompletely understood.
  61. doi Costs of asthma in the United States: 2002-2007
    Sarah Beth L Barnett
    Air Pollution and Respiratory Health Branch, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA
    J Allergy Clin Immunol 127:145-52. 2011
    The economic burden of asthma is an important measure of the effect of asthma on society. Although asthma is a costly illness, the total cost of asthma to society has not been estimated in more than a decade.
  62. pmc IL-17A produced by αβ T cells drives airway hyper-responsiveness in mice and enhances mouse and human airway smooth muscle contraction
    Makoto Kudo
    Lung Biology Center, Department of Medicine, University of California, San Francisco, California, USA
    Nat Med 18:547-54. 2012
    ..evidence suggests that the T helper 17 (T(H)17) subset of αβ T cells contributes to the development of allergic asthma. In this study, we found that mice lacking the αvβ8 integrin on dendritic cells did not generate T(H)17 cells in ..
  63. ncbi Role of deficient type III interferon-lambda production in asthma exacerbations
    Marco Contoli
    Department of Respiratory Medicine, National Heart and Lung Institute, Imperial College London, Norfolk Place, London W2 1PG, UK
    Nat Med 12:1023-6. 2006
    Rhinoviruses are the major cause of asthma exacerbations, and asthmatics have increased susceptibility to rhinovirus and risk of invasive bacterial infections...
  64. doi Role of transforming growth factor-β in airway remodeling in asthma
    Rabih Halwani
    Prince Naif Center for Immunology Research, College of Medicine, King Saud University, Riyadh, Saudi Arabia
    Am J Respir Cell Mol Biol 44:127-33. 2011
    ..High expression of TGF-β in patients with asthma was reported by many investigators...
  65. doi Innate and adaptive immune responses in asthma
    Stephen T Holgate
    Clinical and Experimental Sciences, Sir Henry Wellcome Laboratories, Southampton General Hospital, UK
    Nat Med 18:673-83. 2012
    The recognition that asthma is primarily an inflammatory disorder of the airways associated with T helper type 2 (T(H)2) cell-dependent promotion of IgE production and recruitment of mast cells and eosinophils has provided the rationale ..
  66. pmc Allergic sensitization through the airway primes Th17-dependent neutrophilia and airway hyperresponsiveness
    Rhonda H Wilson
    Division of Intramural Research, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, North Carolina 27709, USA
    Am J Respir Crit Care Med 180:720-30. 2009
    ..Many animal models of asthma bypass this route and instead use intraperitoneal injections of allergen using aluminum hydroxide as an adjuvant.
  67. doi Eosinophils: biological properties and role in health and disease
    Simon P Hogan
    Clin Exp Allergy 38:709-50. 2008
    ..their interaction with mast cells and T cells) and their proposed role in disease processes including infections, asthma, and gastrointestinal disorders...
  68. pmc Allergenicity resulting from functional mimicry of a Toll-like receptor complex protein
    Aurelien Trompette
    Division of Molecular Immunology, Cincinnati Children s Hospital Medical Center and the University of Cincinnati College of Medicine, Cincinnati, Ohio 45229, USA
    Nature 457:585-8. 2009
    ..Mirroring this, airway sensitization and challenge with Der p 2 led to experimental allergic asthma in wild type and MD-2-deficient, but not TLR4-deficient, mice...
  69. pmc Genome-wide association study identifies HLA-DP as a susceptibility gene for pediatric asthma in Asian populations
    Emiko Noguchi
    Department of Medical Genetics, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Japan
    PLoS Genet 7:e1002170. 2011
    b>Asthma is a complex phenotype influenced by genetic and environmental factors. We conducted a genome-wide association study (GWAS) with 938 Japanese pediatric asthma patients and 2,376 controls...
  70. doi Discovering susceptibility genes for asthma and allergy
    Donata Vercelli
    Functional Genomics Laboratory, Arizona Respiratory Center, Department of Cell Biology and The Bio5 Institute, University of Arizona, PO Box 245044, Tucson, Arizona 85724 5044, USA
    Nat Rev Immunol 8:169-82. 2008
    b>Asthma and asthma-related traits are complex diseases with strong genetic and environmental components...
  71. doi Smoke-free legislation and hospitalizations for childhood asthma
    Daniel Mackay
    Section of Public Health, University of Glasgow, Glasgow, United Kingdom
    N Engl J Med 363:1139-45. 2010
    ..The aim of our study was to determine whether the ban on smoking in public places in Scotland, which was initiated in March 2006, influenced the rate of hospital admissions for childhood asthma.
  72. doi Cord-blood 25-hydroxyvitamin D levels and risk of respiratory infection, wheezing, and asthma
    Carlos A Camargo
    Center for D receptor Activation Research, Massachusetts General Hospital, 326 Cambridge St, Suite 410, Boston, MA 02114, USA
    Pediatrics 127:e180-7. 2011
    ..The relationship between cord-blood levels of 25-hydroxyvitamin D (25[OH]D) and childhood wheezing is unknown. We hypothesized that cord-blood levels would be inversely associated with risk of respiratory infection, wheezing, and asthma.
  73. pmc Complement-mediated regulation of the IL-17A axis is a central genetic determinant of the severity of experimental allergic asthma
    Stephane Lajoie
    Division of Immunobiology, Cincinnati Children s Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
    Nat Immunol 11:928-35. 2010
    Severe asthma is associated with the production of interleukin 17A (IL-17A). The exact role of IL-17A in severe asthma and the factors that drive its production are unknown...
  74. pmc Helicobacter pylori infection prevents allergic asthma in mouse models through the induction of regulatory T cells
    Isabelle C Arnold
    Institute of Molecular Cancer Research, University of Zurich, Zurich, Switzerland
    J Clin Invest 121:3088-93. 2011
    Atopic asthma is a chronic disease of the airways that has taken on epidemic proportions in the industrialized world...
  75. ncbi Inflammatory subtypes in asthma: assessment and identification using induced sputum
    Jodie L Simpson
    School of Medical Practice and Population Health, Hunter Medical Research Institute, The University of Newcastle, Callaghan, New South Wales, Australia
    Respirology 11:54-61. 2006
    The authors sought to investigate the detection of non-eosinophilic asthma using induced sputum. Although this is an important subtype of clinical asthma, its recognition is not standardized.
  76. pmc The cytokine network in asthma and chronic obstructive pulmonary disease
    Peter J Barnes
    National Heart and Lung Institute, Imperial College London, London, UK
    J Clin Invest 118:3546-56. 2008
    b>Asthma and chronic obstructive pulmonary disease (COPD) are very common inflammatory diseases of the airways. They both cause airway narrowing and are increasing in incidence throughout the world, imposing enormous burdens on health care...
  77. pmc Active albuterol or placebo, sham acupuncture, or no intervention in asthma
    Michael E Wechsler
    Division of Pulmonary and Critical Care Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    N Engl J Med 365:119-26. 2011
    In prospective experimental studies in patients with asthma, it is difficult to determine whether responses to placebo differ from the natural course of physiological changes that occur without any intervention...
  78. pmc Regulatory T cells in asthma
    Clare M Lloyd
    Medical Research Council and Asthma UK Centre in Allergic Mechanisms of Asthma, NHLI, Imperial College, London SW7 2AZ, UK
    Immunity 31:438-49. 2009
    b>Asthma is characterized by T helper cell 2 (Th2) type inflammation, leading to airway hyperresponsiveness and tissue remodeling. Th2 cell-driven inflammation is likely to represent an abnormal response to harmless airborne particles...
  79. pmc T-helper type 2-driven inflammation defines major subphenotypes of asthma
    Prescott G Woodruff
    Division of Pulmonary and Critical Care Medicine, University of California, San Francisco, San Francisco, CA 94143 0111, USA
    Am J Respir Crit Care Med 180:388-95. 2009
    ..2 (Th2) inflammation, mediated by IL-4, IL-5, and IL-13, is considered the central molecular mechanism underlying asthma, and Th2 cytokines are emerging therapeutic targets...
  80. doi Sequence variants affecting eosinophil numbers associate with asthma and myocardial infarction
    Daniel F Gudbjartsson
    deCODE Genetics, Sturlugata 8, 101 Reykjavik, Iceland
    Nat Genet 41:342-7. 2009
    ..4 x 10(-10), 8.6 x 10(-17), 1.2 x 10(-10) and 6.5 x 10(-19), respectively). A SNP at IL1RL1 associated with asthma (P = 5.5 x 10(-12)) in a collection of ten different populations (7,996 cases and 44,890 controls)...
  81. pmc Vascular endothelial growth factor (VEGF) induces remodeling and enhances TH2-mediated sensitization and inflammation in the lung
    Chun Geun Lee
    Section of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Yale University School of Medicine, 300 Cedar Street, 441c TAC, New Haven, Connecticut 06520 8057, USA
    Nat Med 10:1095-103. 2004
    Exaggerated levels of VEGF (vascular endothelial growth factor) are present in persons with asthma, but the role(s) of VEGF in normal and asthmatic lungs has not been defined...
  82. ncbi Asthma Control Test: reliability, validity, and responsiveness in patients not previously followed by asthma specialists
    Michael Schatz
    Kaiser Permanente Medical Center, San Diego, CA 92111, USA
    J Allergy Clin Immunol 117:549-56. 2006
    The development of the Asthma Control Test (ACT), a short, simple, patient-based tool for identifying patients with poorly controlled asthma, was recently described in patients under the routine care of an asthma specialist.
  83. pmc Protectin D1 is generated in asthma and dampens airway inflammation and hyperresponsiveness
    Bruce D Levy
    Pulmonary and Critical Care Medicine, Department of Internal Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Immunol 178:496-502. 2007
    ..PD1, 10R,17S-dihydroxy-docosa-4Z,7Z,11E,13E,15Z,19Z-hexaenoic acid) formation from docosahexaenoic acid in human asthma in vivo and PD1 counterregulatory actions in allergic airway inflammation...
  84. pmc Oral tolerance in the absence of naturally occurring Tregs
    Daniel Mucida
    Program of Molecular Pathogenesis, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, NY 10016, USA
    J Clin Invest 115:1923-33. 2005
    ..environmental and food antigens, and its failure results in exacerbated inflammation typical of allergies and asthma. One of the proposed mechanisms of oral tolerance is the induction of Tregs...
  85. ncbi Airway smooth muscle cell proliferation is increased in asthma
    P R Johnson
    Department of Pharmacology, University of Sydney, Sydney, Australia
    Am J Respir Crit Care Med 164:474-7. 2001
    ..05). This study shows for the first time that proliferation of ASM cells is increased in patients with asthma and provides evidence for an intrinsic abnormality in the ASM cell in this disease.
  86. pmc Mapping of numerous disease-associated expression polymorphisms in primary peripheral blood CD4+ lymphocytes
    Amy Murphy
    Channing Laboratory, Department of Medicine, Division of Pulmonary and Critical Care Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Hum Mol Genet 19:4745-57. 2010
    ..41 × 10(-6)), and although many of the implicated loci were associated with immune-related diseases (including asthma, connective tissue disorders and inflammatory bowel disease), associations with genes implicated in non-immune-..
  87. doi Regulatory B cells prevent and reverse allergic airway inflammation via FoxP3-positive T regulatory cells in a murine model
    Sylvie Amu
    Institute of Molecular Medicine, Trinity College Dublin, Dublin, Ireland
    J Allergy Clin Immunol 125:1114-1124.e8. 2010
    ..Experimentally, infection of mice with the helminth Schistosoma mansoni prevents allergic airway inflammation and anaphylaxis via IL-10 and B cells...
  88. pmc Human asthma phenotypes: from the clinic, to cytokines, and back again
    Nirav R Bhakta
    Division of Pulmonary and Critical Care Medicine, Department of Medicine and Cardiovascular Research Institute, University of California San Francisco, San Francisco, CA, USA
    Immunol Rev 242:220-32. 2011
    ..However, human asthma is heterogeneous with respect to clinical features, cellular sources of inflammation, and response to common ..
  89. doi Th17 cells: new players in asthma pathogenesis
    L Cosmi
    Center of Excellence for Research, Transfer of Research and High Education for the Development of Novel therapies, University of Florence, Florence, Italy
    Allergy 66:989-98. 2011
    ..b>Asthma is an inflammatory disease characterized by different clinical phenotypes...
  90. doi Angiogenesis and lymphangiogenesis in bronchial asthma
    A Detoraki
    Department of Clinical Immunology and Allergy, Center for Basic and Clinical Immunology Research CISI, University of Naples Federico II, Naples
    Allergy 65:946-58. 2010
    ..number and size, vascular surface area and vascular leakage are all increased in biopsies from patients with asthma. High levels of VEGF and other angiogenic factors have been detected in tissues and biological samples of patients ..
  91. doi Diet and asthma: nutrition implications from prevention to treatment
    Keith Allan
    Royal Aberdeen Children s Hospital Department of Child Health, University of Aberdeen, Aberdeen, Scotland
    J Am Diet Assoc 111:258-68. 2011
    b>Asthma is characterized by lung airway inflammation initiated and perpetuated by an inappropriate immune response, increased airway responsiveness, and variable airflow obstruction...
  92. doi Filaggrin mutations, atopic eczema, hay fever, and asthma in children
    Stephan Weidinger
    Department of Dermatology and Allergy, Technical University Munich, Munich, Germany
    J Allergy Clin Immunol 121:1203-1209.e1. 2008
    ..However, their role in the development of other atopic diseases such as asthma and rhinitis has not yet been clarified in large population-based studies.
  93. pmc Mothers' anxiety during pregnancy is associated with asthma in their children
    Hannah Cookson
    Department of Internal Medicine, Sir Charles Gairdner Hospital, Perth, Australia
    J Allergy Clin Immunol 123:847-53.e11. 2009
    Maternal stress in early life has been associated with the development of asthma in children, although it is unclear whether there are any critical periods of exposure...
  94. pmc Environmental epigenetics of asthma: an update
    Shuk Mei Ho
    Department of Environmental Health, Center for Environmental Genetics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
    J Allergy Clin Immunol 126:453-65. 2010
    b>Asthma, a chronic inflammatory disorder of the airway, is influenced by interplay between genetic and environmental factors now known to be mediated by epigenetics...
  95. doi Decreased FOXP3 protein expression in patients with asthma
    S Provoost
    Department of Respiratory Medicine, Ghent University Hospital, Ghent, Belgium
    Allergy 64:1539-46. 2009
    ..Current evidence suggests that asthma is characterized by a relative deficiency in T(reg), allowing T helper 2 cells to expand...
  96. pmc Genome-wide association analysis identifies PDE4D as an asthma-susceptibility gene
    Blanca E Himes
    Harvard MIT Division of Health Sciences and Technology, Cambridge, MA, 02138, USA
    Am J Hum Genet 84:581-93. 2009
    b>Asthma, a chronic airway disease with known heritability, affects more than 300 million people around the world...
  97. pmc Vitamin D levels, lung function, and steroid response in adult asthma
    E Rand Sutherland
    Department of Medicine, University of Colorado, Denver, Colorado, USA
    Am J Respir Crit Care Med 181:699-704. 2010
    Patients with asthma exhibit variable response to inhaled corticosteroids (ICS). Vitamin D is hypothesized to exert effects on phenotype and glucocorticoid (GC) response in asthma.
  98. pmc Genome-wide association study implicates chromosome 9q21.31 as a susceptibility locus for asthma in mexican children
    Dana B Hancock
    Department of Health and Human Services, Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, United States of America
    PLoS Genet 5:e1000623. 2009
    Many candidate genes have been studied for asthma, but replication has varied. Novel candidate genes have been identified for various complex diseases using genome-wide association studies (GWASs)...
  99. pmc MMP12, lung function, and COPD in high-risk populations
    Gary M Hunninghake
    Channing Laboratory and Center for Genomic Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    N Engl J Med 361:2599-608. 2009
    ..Genetic variants influencing lung function in children and adults may ultimately lead to the development of chronic obstructive pulmonary disease (COPD), particularly in high-risk groups...
  100. doi The value of self-report assessment of adherence, rhinitis and smoking in relation to asthma control
    Jane Clatworthy
    Centre for Behavioural Medicine, Department of Practice and Policy, The School of Pharmacy, University of London, BMA House, London, UK
    Prim Care Respir J 18:300-5. 2009
    To explore the utility of self-report measures of inhaled corticosteroid (ICS) adherence, degree of rhinitis and smoking status and their association with asthma control.
  101. pmc Effectiveness and safety of bronchial thermoplasty in the treatment of severe asthma: a multicenter, randomized, double-blind, sham-controlled clinical trial
    Mario Castro
    Washington University School of Medicine, Campus Box 8052, 660 S Euclid, St Louis, MO 63110 1093, USA
    Am J Respir Crit Care Med 181:116-24. 2010
    ..Bronchial thermoplasty (BT) is a bronchoscopic procedure in which controlled thermal energy is applied to the airway wall to decrease smooth muscle...

Research Grants76

  1. Understanding/ Treating Neuropsychiatric Symptoms of Pediatric Physical Illness
    Eva Szigethy; Fiscal Year: 2009
    ..abstract_text> ..
  2. ASTHMA AND ALLERGIC DISEASE CENTER
    Thomas A Platts Mills; Fiscal Year: 2010
    ..by applicant): The research program of the University of Virginia has focused on investigating the etiology of asthma, looking both at risk factors for the disease and the complex events surrounding an acute episode...
  3. Cellular &Inflammatory Pathways in Ashtma &Allergic Diseases: From IgE to Cells
    LAWRENCE BARRY SCHWARTZ; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Asthma and allergic diseases are multifactorial, complex diseases involving the innate and adaptive immune systems as well as environmental factors...
  4. Induction and maintenance of regulatory T cells
    Mitchell Kronenberg; Fiscal Year: 2013
    ..They work in relevant animal models of infection and immune mediated diseases such as type I diabetes, colitis and asthma. In Project 1, led by Dr...
  5. BIOSYNTHESIS OF TRACHEAL MUCOUS GLYCOPROTEINS
    Pi Wan Cheng; Fiscal Year: 2010
    Mucus hypersecretion is a hallmark of obstructive lung diseases, including chronic bronchitis, asthma, and cystic fibrosis. This condition is the result of hypertrophy and hyperplasia of mucus cells...
  6. VitC to Decrease Effects of Smoking in Pregnancy on Infant Lung Function-CCC-Lead
    CYNTHIA T MCEVOY; Fiscal Year: 2013
    ..This addiction is the largest preventable cause of childhood respiratory illness, including asthma, and children whose mothers smoked during pregnancy show lifetime decreases in pulmonary function...
  7. Neural mechanisms by which chronic stress regulates inflammation in asthma
    Melissa A Rosenkranz; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Asthma is a chronic inflammatory disease that poses a significant public health problem affecting approximately 13% of U.S. adults...
  8. Alternative Macrophage Activation Limits Immunopathology
    DEBROSKI R HERBERT; Fiscal Year: 2011
    ..a central role in regulating the pathogenesis and expression of diseases as diverse as sepsis, atherosclerosis and asthma. Infection with diverse bacteria and viruses gives rise to classically activated macrophages (CAMF), which produce ..
  9. Regulation of Airway Mucin Gene Expression by Epigenetic Mechanism
    Reen Wu; Fiscal Year: 2013
    ..due to mucin overproduction is one of major clinical symptoms associated with various lung diseases, such as asthma, cystic fibrosis, bronchitis, chronic obstructive pulmonary diseases, etc...
  10. Bi-functional Therapeutics for Allergy-BFTA
    Swey Shen Chen; Fiscal Year: 2010
    ..by applicant): IgE-mediated allergic diseases, afflicting 25% of the US population, are manifested as allergic asthma, rhinitis, food allergy, atopic dermatitis, and anaphylaxis...
  11. Unbiased genome-wide screen to identify genes regulating mucous cell hyperplasia
    Jeffrey A Whitsett; Fiscal Year: 2010
    ..of therapeutic interest for the treatment of common, chronic and acute pulmonary disorders, including CF, COPD and asthma. This proposal is responsive to the broad challenge area 15 "Translational Science" and Challenge topic 04-HL-102, ..
  12. Endotoxin, the airway transcriptome, and obstructive lung disease
    PEGGY SUE LAI; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Research Asthma and chronic obstructive pulmonary disease (COPD) are chronic inflammatory lung diseases that affect an estimated 35 million Americans...
  13. FASEB SUMMER CONFERENCE ON PHOSPHOLIPASES
    Alex Brown; Fiscal Year: 2010
    ..processes such as renal perfusion, gastric cytoprotection, hemostasis, cancer, host defense, inflammation, and asthma. Phospholipase C generates inositol phosphate and diglyceride second messengers in response to agonist activation ..
  14. Effect of diet & commensal bacteria on diabetes outcome in NOD mouse
    Li Wen; Fiscal Year: 2010
    ..Epidemiological studies have shown the sharp rise of allergy (dermatitis or food allergy), asthma, obesity and type 1 diabetes (T1D) in the US and worldwide in the past two decades...
  15. Novel Macrolide Th17 Inhibitors
    Jay K Kolls; Fiscal Year: 2012
    ..IL-17F have been implicated in chronic inflammatory diseases including cystic fibrosis, COPD and steroid resistant asthma. Furthermore these cytokines have been implicated in autoimmune diseases such as multiple sclerosis and rheumatoid ..
  16. Neurotrophins in the Lung
    Y S Prakash; Fiscal Year: 2012
    ..been found in different lung components including airway smooth muscle (ASM), with altered expression observed in asthma, allergy, and even lung cancer...
  17. Preclinical drug trial in mouse models of inflammation
    Kanneboyina Nagaraju; Fiscal Year: 2011
    ..these novel non-hormonal steroids significantly reduce inflammation and improve muscle function, arthritis and asthma phenotypes without causing significant adverse effects. Aim.1...
  18. Lipid Binding Proteins in Obesity and Diabetes Syndromes
    David A Bernlohr; Fiscal Year: 2013
    ..and increased adiponectin expression, improved insulin sensitivity, decreased NF-?B activation, protection from asthma and diminished atherogenic capacity...
  19. A novel telomerase expressing lung fibroblast phenotype
    Sem H Phan; Fiscal Year: 2012
    ..fibrotic lung diseases, such as interstitial lung diseases, chronic obstructive pulmonary disease (COPD) and asthma. Induction of telomerase has been observed in animal models of lung injury and fibrosis, and recent evidence ..
  20. Lung VITamin D and OmegA-3 TriaL (Lung VITAL)
    Diane R Gold; Fiscal Year: 2013
    ..b>Asthma often coexists with COPD in adults and worsens COPD progression...
  21. Dependency of O-3 Induced Lung Mucus Hypersecretion on NQ01
    W Michael Foster; Fiscal Year: 2010
    ..For patients with asthma, chronic obstructive pulmonary disease (COPD), and cystic fibrosis, mucus hypersecretion is now being considered ..
  22. Asthma Increases Vaso-occlusion in Sickle Cell Disease
    Kirkwood A Pritchard; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Asthma is a co-morbid condition that increases morbidity and mortality of children who have sickle cell disease (SCD)...
  23. VitC to Decrease Effects of Smoking in Pregnancy on Infant Lung Function-DCC
    Cynthia D Morris; Fiscal Year: 2013
    ..This addiction is the largest preventable cause of childhood respiratory illness, including asthma, and children whose mothers smoked during pregnancy show lifetime decreases in pulmonary function...
  24. Scavenging of Reactive Oxygen and Nitrogen Species by Cobalamins
    NICOLA ELIZABETH BRASCH; Fiscal Year: 2011
    ..over several decades to treat inflammatory disorders including chronic fatigue syndrome, rheumatoid arthritis, asthma, neurological diseases and eczema, with little understanding as to why B12 supplementation is beneficial...
  25. Lipid Binding Proteins in Obesity and Diabetes Syndromes
    David A Bernlohr; Fiscal Year: 2011
    ..adiponectin expression, improved insulin sensitivity, decreased NF-&#954;B activation, protection from asthma and diminished atherogenic capacity...
  26. Pulmonary effects of biomass fuel indoor PM from rural India
    Shyam Biswal; Fiscal Year: 2013
    ..might be the biggest risk factor for respiratory diseases such as chronic obstructive pulmonary disease (COPD), asthma, and respiratory infections globally...
  27. Mechanisms and Enviromental Determinants of Rhinovirus Illness Severity
    James E Gern; Fiscal Year: 2013
    ..illness including bronchiolitis, influenza-like illness, and exacerbations of chronic lung diseases such as asthma, cystic fibrosis, and chronic obstructive lung disease (COPD)...
  28. Eosinophil ORMDL3 and allergic inflammation
    P Sriramarao; Fiscal Year: 2012
    ..have led to the identification of orosomucoid 1-like 3 (ORMDL3) as a candidate gene for susceptibility to asthma. Apart from very recent studies demonstrating that ORMDL3 functions as a mediator of sphingolipid homeostasis in ..
  29. Reversing Corticosteroid-Induced Memory Impairment
    E Sherwood Brown; Fiscal Year: 2013
    ..We propose a randomized, double-blind, placebo-controlled pilot study of lamotrigine in 50 outpatients with asthma receiving chronic oral corticosteroid therapy...
  30. Genetic and Pharmacologic Evaluation of the Role of HIF-1a in asthma
    LAURA ELISE CROTTY ALEXANDER; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Asthma is an extremely common disease, affecting 6.4% of American adults over the course of their lives1...
  31. Myosin phosphatase autoinhibition in gastrointestinal smooth muscle contraction
    Avril V Somlyo; Fiscal Year: 2012
    ..induced decreased gut motility, hypertension, cerebral and coronary vasospasm, erectile dysfunction, and bronchial asthma, among other diseases are caused by abnormal contraction and relaxation of smooth muscle tissues...
  32. Nitric Oxide Signaling with Heme Proteins
    William R Montfort; Fiscal Year: 2012
    ..attractive targets for intervention in many diseases, including cardiovascular disease, cancer, diabetes and asthma. In past funding period, we uncovered the means by which the nitrophorins, NO transport proteins from blood-..
  33. Proteomic signatures of an early life asthma-protective exposure
    Serrine S Lau; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Project title: Proteomic signatures of an early life asthma-protective exposure Challenge Area: 03 Biomarker discovery and validation Challenge Topic: Validation of new exposure assessment ..
  34. TNF Family Members and Control of Fibrotic Disease
    Michael Croft; Fiscal Year: 2013
    ..Fibrosis is a feature that is shared with other syndromes such as severe asthma and COPD, and therefore preventing the onset of fibrosis or blocking continued fibrosis is of great significance ..
  35. Preclinical drug trial in mouse models of inflammation
    Kanneboyina Nagaraju; Fiscal Year: 2013
    ..these novel non-hormonal steroids significantly reduce inflammation and improve muscle function, arthritis and asthma phenotypes without causing significant adverse effects. Aim.1...
  36. Development of Montelukast Delivery System for Childhood Asthma
    Je Phil Ryoo; Fiscal Year: 2013
    ..are primarily endogenous mediators of inflammation and play an integral role in the pathophysiology of asthma. Activation of leukotriene receptor has numerous effects in the lungs, including increased bronchial hyper ..
  37. PREVENTION OF QUINONE TOXICITY AND MUTAGENICITY
    ANIL KUMAR JAISWAL; Fiscal Year: 2013
    ..This together with epidemiological reports of association between NQO1P187S mutation and asthma raise intriguing questions regarding the role of NQO1/NQO2 in cigarette smoke-induced pulmonary emphysema...
  38. Effect of Neonatal Hyperoxia on Alveolar Development and Infection
    MICHAEL A O'REILLY; Fiscal Year: 2012
    ..indicate children who had been exposed to elevated oxygen at birth are more likely to have viral infections, asthma, increased sensitivity to second hand cigarette smoke, and more out-of-school sick days than children who were not ..
  39. Research Training in Cardiovascular and Pulmonary Diseases
    S Jamal Mustafa; Fiscal Year: 2012
    ..Disease relevance of trainee projects are numerous;eg. coronary ischemia, asthma, pulmonary edema, hypertension, cardiac failure, intestinal vascular inflammation, pulmonary fibrosis, peripheral ..
  40. Dietary Scavenging of Reactive Species in Lung Injury: Role of Macrophages
    THEA NOREEN GOLDEN; Fiscal Year: 2013
    ..An alteration of NO production has been implicated in the pathology of numerous respiratory diseases such as asthma, emphysema and the acute respiratory distress syndrome...
  41. ROLE OF MUC1 IN THE GENESIS OF ALLERGIC ASTHMA
    Kwang Chul Kim; Fiscal Year: 2010
    ..pulmonary eosinophilia and goblet cell hyperplasia as seen in wild type littermates in an ovalbumin (OVA)-induced asthma model...
  42. Inducible Macrophage Specific Gene Expression in Diseases
    JEANINE M D apos ARMIENTO; Fiscal Year: 2010
    ..and inducibility of Cre expression will be assessed in three models of lung injury (cigarette smoke exposure, asthma, and acute lung injury)...
  43. Interactions of Diesel Exhaust and Respiratory Viruses in Asthmatic Children
    Toby C Lewis; Fiscal Year: 2013
    ..air pollution and respiratory viral infections (URIs) are well-documented, independent stimulants of asthma symptoms, and both are associated with significant asthma morbidity...
  44. Cellular interactions in asthma
    CHRISTOPHER DAVID CABALLERO ALLEN; Fiscal Year: 2012
    DESCRIPTION (Provided by the applicant) Abstract: Asthma is a lung disease that causes constriction of the airways in response to triggers such as pollen, mold, viral infection, or even cold air...
  45. High Throughput Methods to Measure Disparities in Childhood Exposure to Tobacco
    Sharon E Murphy; Fiscal Year: 2010
    ..SHS exposure is associated with important health problems such as low birth- weight, asthma induction, asthma exacerbation, increased ear and lower respiratory infections, and sudden infant death syndrome...
  46. Anti- IL5 therapy for Churg-Strauss Syndrome: a double blind randomized, placebo-
    Michael E Wechsler; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Churg-Strauss syndrome (CSS) is a complex syndrome associated with asthma, anti-neutrophil cytoplasmic antibodies, and eosinophilic vasculitis involving multiple organs including the lungs, heart, ..
  47. Surveillance of Serum Contents by Mast Cells and Regulation of Allergic Immunity
    Laurence E Cheng; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The prevalence of allergic diseases, including food allergies, eczema, and asthma, has risen over the last quarter century, and these disorders can lead to significant morbidity for affected patients...
  48. Regulation/Role of AcylCer in Normal Epidermis and Atopic Dermatitis
    Peter M Elias; Fiscal Year: 2013
    ..resulting in increased transcutaneous exposure to allergens which induce AD, and stimulate progression of AD to asthma and allergic rhinitis...
  49. Periostin Regulation of Lung Fibrosis
    Bethany B Moore; Fiscal Year: 2013
    ..Recently, the TGFb-regulated matricellular protein, periostin, a molecule which has been studied in asthma, atherosclerosis and cancer, has been implicated in the pathogenesis of interstitial fibrotic lung disease...
  50. NICHD Maternal Fetal Medicine Units Network
    Geeta K Swamy; Fiscal Year: 2013
    ..High risk conditions like hypertension, diabetes, asthma, multi-fetal gestation, prematurity, and low birthweight occur among half of all births across DUHS...
  51. Development of Bioactive Chemical Probes for Calcium-activated Chloride Channel
    Min Li; Fiscal Year: 2012
    ..Abnormality of CaCC is thought to be causal to diseases, such as cystic fibrosis, asthma, chronic bronchitis, and hypertension...
  52. Targeting Siglec-8/-F to treat eosinophil and mast cell related disorders
    Bruce S Bochner; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): In anaphylaxis, asthma and other forms of acute and chronic allergic diseases, eosinophils and mast cells, through release of preformed and newly generated mediators, granule proteins, and cytokines, ..
  53. Targeting Siglec-8/-F to treat eosinophil and mast cell related disorders
    Bruce S Bochner; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): In anaphylaxis, asthma and other forms of acute and chronic allergic diseases, eosinophils and mast cells, through release of preformed and newly generated mediators, granule proteins, and cytokines, ..
  54. Developing a New Antioxidant Activator to Intervene in Lung Inflammatory Diseases
    JOHN WILLIMANN; Fiscal Year: 2009
    ..S. These diseases include allergic asthma, chronic obstructive pulmonary disease, viral and bacterial infections, and related sepsis-induced acute lung ..
  55. Research Career Development in Child Health
    Michael W Konstan; Fiscal Year: 2012
    ..and evolution of numerous childhood diseases, including lung disease associated with prematurity, cystic fibrosis, asthma, pneumonia, sepsis, cancer, coagulation disorders, bone marrow transplantation, diabetes, obesity and ..
  56. A Novel Model of, and Pre-clinical Therapy for, Scleroderma Lung Disease
    Sergei P Atamas; Fiscal Year: 2012
    ..SLD, mIL-442 does not induce pulmonary eosinophilia or goblet cell hyperplasia (the features that are common in asthma but not in SLD, and that are readily induced by wild-type mIL-4)...
  57. Environmental Chitin Exposure in the Pathogenesis of Asthma
    Rene M Roy; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Asthma is a chronic inflammatory disease that profoundly impacts the quality of life of affected individuals and heavily burdens the national health care system...
  58. Genetic Determinants of Lung Injury
    Beverly H Koller; Fiscal Year: 2013
    ..Oxidative stress has been implicated in the pathogenesis of many acute and chronic lung diseases including asthma and chronic obstructive pulmonary disease (COPD)...
  59. The function and regulation of IL-33 in the airway epithelium in asthma
    ERIN D GORDON; Fiscal Year: 2013
    ..applicant): In this revised application entitled "Function and Regulation of IL-33 in Airway Epithelial Cells in Asthma" for the Mentored Clinical Scientist Research Career Development Award, I propose a comprehensive plan of research ..
  60. Lung Toxicity of Carbon Nanotubes in Models of Pre-Existing Respiratory Disease
    JAMES CHRISTOPHER BONNER; Fiscal Year: 2010
    ..We recently reported that CNTs also exacerbate the development of allergic asthma in mice and increase pulmonary fibrosis in mice pre-exposed to bacterial lipopolysaccharide (LPS)...
  61. Perinatal Programming of Infant Stress Reactivity and the Atopic Phenotype
    Rosalind J Wright; Fiscal Year: 2013
    ..of atopy, predisposing individuals to a spectrum of disorders, allergic rhinitis, atopic dermatitis, and allergic asthma. Evidence linking psychological stress to atopy expression has grown with our increased understanding of the ..
  62. Translational Approaches to Reducing Health Disparities in Lung Disease
    Joe G N Garcia; Fiscal Year: 2012
    ..compared to Caucasians that is one of the major factors that contribute to the health disparities seen in asthma and COPD. African Americans are three times more likely to succumb to asthma compared to Caucasians...
  63. Allergic asthma and chromium exposure
    Steven R Patierno; Fiscal Year: 2010
    ..Along with an increased risk of lung cancer, a high incidence of allergic asthma has been reported in industrial workers exposed to inhaled particulate Cr(VI)...
  64. Mouse models for the functional analysis of asthma-associated human polymorphisms
    Donata Vercelli; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Asthma and allergy are marked by a profound dysregulation of Th2 responses and increased expression of the Th2 cytokines IL5, IL13 and IL4...
  65. Chicago Westside Partnership for Children's Asthma Initiative (CWPC-AI)
    Steven Whitman; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Project Summary/Abstract Asthma is one condition that disproportionately affects poor and minority children living in inner-city neighborhoods...
  66. Development of anti-human TL1A monoclonal antibody for the treatment of human ast
    Vadim V Deyev; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Asthma is a chronic, debilitating disease characterized by intermittent attacks of wheezing, shortness of breath, chest tightness, cough and excess sputum/mucus production...
  67. LUNG DRUG DELIVERY WITH CARBON DIOXIDE AEROSOL INHALERS
    Brian Hansen; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Asthma is one of the most common and costly illnesses in the US, with over 20 million Americans suffering from asthma with an annual societal cost of over $18 billion...
  68. VSL for Asthma
    Alessio Fasano; Fiscal Year: 2009
    ..microbiota related to diet and common use of antibiotics are strongly associated with allergies and asthma. Probiotics (those microbes that produce only beneficial effects in the host gut), such as Lactobacillus and ..
  69. VSL for Asthma
    Alessio Fasano; Fiscal Year: 2010
    ..microbiota related to diet and common use of antibiotics are strongly associated with allergies and asthma. Probiotics (those microbes that produce only beneficial effects in the host gut), such as Lactobacillus and ..
  70. ASTHMA--ALTERNATIVE MEDICINE CENTER
    MERRILL GERSHWIN; Fiscal Year: 2000
    DESCRIPTION (adapted from investigator's abstract): Despite developments in understanding the nature of asthma and developing new treatment procedures, a somber fact is that asthma incidence has increased by more than 30 percent since ..
  71. Early Environmental Hygiene and Pediatric Asthma
    Christine C Johnson; Fiscal Year: 2009
    The prevalence of asthma has increased over the 20th century in most, if not all, developed countries of the world...
  72. A+ Asthma Rural Partnership
    Arlene Butz; Fiscal Year: 2004
    ..and familial factors in rural communities predispose children to chronic health conditions, including asthma. Asthma is the most common chronic disease of childhood, affecting 7...
  73. CHICAGO INNER CITY ASTHMA STUDY
    Richard Evans; Fiscal Year: 2001
    Data from NCICAS indicate that a multiplicity of risk factors interact to increase the severity of asthma in poor, urban minority children...
  74. Chitosan IFNgamma-pDNA Nanosphere Therapy and Immunopathology of Allergic Asthma
    Shyam Mohapatra; Fiscal Year: 2006
    With an intent to develop effective prophylaxis or treatment of allergic diseases including allergic asthma, our goal is to examine the safety and efficacy of chitosan IFN-gamma-pDNA nanosphere (CIN) Therapy and the cellular and molecular ..
  75. Racial/ethnic differences in symptom perception in childhood asthma
    Jonathan Feldman; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): The greatest racial/ethnic disparity in pediatric asthma exists between the two largest Latino ethnic groups in the United States...
  76. Comorbid Anxiety Disorders in Adolescents with Asthma
    Wayne Katon; Fiscal Year: 2006
    unreadable] DESCRIPTION (provided by investigator): Asthma is the most common chronic illness of childhood and adolescence, and the prevalence rate is increasing...