amebiasis

Summary

Summary: Infection with any of various amebae. It is an asymptomatic carrier state in most individuals, but diseases ranging from chronic, mild diarrhea to fulminant dysentery may occur.

Top Publications

  1. ncbi In-vitro activity of miltefosine and voriconazole on clinical isolates of free-living amebas: Balamuthia mandrillaris, Acanthamoeba spp., and Naegleria fowleri
    Frederick L Schuster
    California Department of Health Services, Viral and Rickettsial Disease Laboratory, Richmond, California 94804, USA
    J Eukaryot Microbiol 53:121-6. 2006
  2. ncbi Reassessment of the epidemiology of amebiasis: state of the art
    Cecilia Ximenez
    Departamento de Medicina Experimental, Facultad de Medicina, Universidad Nacional Autonoma de Mexico, Mexico DF, Mexico
    Infect Genet Evol 9:1023-32. 2009
  3. ncbi Free-living amoebae as opportunistic and non-opportunistic pathogens of humans and animals
    Frederick L Schuster
    Viral and Rickettsial Disease Laboratory, California Department Health Services, 850 Marina Bay Parkway, Richmond, CA 94804, USA
    Int J Parasitol 34:1001-27. 2004
  4. ncbi Pathogenic and opportunistic free-living amoebae: Acanthamoeba spp., Balamuthia mandrillaris, Naegleria fowleri, and Sappinia diploidea
    Govinda S Visvesvara
    Division of Parasitic Diseases, National Center for Infectious Diseases, Atlanta, Georgia 30341 3724, USA
    FEMS Immunol Med Microbiol 50:1-26. 2007
  5. pmc PCR-based diagnosis of Naegleria sp. infection in formalin-fixed and paraffin-embedded brain sections
    Marc Schild
    Institute of Parasitology, University of Berne, Langgass strasse 122, CH 3012 Bern, Switzerland
    J Clin Microbiol 45:564-7. 2007
  6. ncbi Epidemiology of amebiasis in a region of high incidence of amebic liver abscess in central Vietnam
    Joerg Blessmann
    Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany
    Am J Trop Med Hyg 66:578-83. 2002
  7. pmc The dynamic interdependence of amebiasis, innate immunity, and undernutrition
    Hans P Verkerke
    Division of Infectious Diseases and International Health, University of Virginia Health System, Charlottesville, VA 22903, USA
    Semin Immunopathol 34:771-85. 2012
  8. ncbi Origin and evolution of the worldwide distributed pathogenic amoeboflagellate Naegleria fowleri
    Johan F De Jonckheere
    Research Unit for Tropical Diseases, de Duve Institute, Brussels, Belgium
    Infect Genet Evol 11:1520-8. 2011
  9. ncbi Amoebiasis
    Samuel L Stanley
    Department of Medicine, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO, St Louis, MO 63110, USA
    Lancet 361:1025-34. 2003
  10. ncbi Opportunistic amoebae: challenges in prophylaxis and treatment
    Frederick L Schuster
    Viral and Rickettsial Disease Laboratory, California Department of Health Services, Richmond, CA 94804, USA
    Drug Resist Updat 7:41-51. 2004

Detail Information

Publications242 found, 100 shown here

  1. ncbi In-vitro activity of miltefosine and voriconazole on clinical isolates of free-living amebas: Balamuthia mandrillaris, Acanthamoeba spp., and Naegleria fowleri
    Frederick L Schuster
    California Department of Health Services, Viral and Rickettsial Disease Laboratory, Richmond, California 94804, USA
    J Eukaryot Microbiol 53:121-6. 2006
    ..Miltefosine and voriconazole are potentially useful drugs for treatment of free-living amebic infections, though sensitivities differ between genera, species, and strains...
  2. ncbi Reassessment of the epidemiology of amebiasis: state of the art
    Cecilia Ximenez
    Departamento de Medicina Experimental, Facultad de Medicina, Universidad Nacional Autonoma de Mexico, Mexico DF, Mexico
    Infect Genet Evol 9:1023-32. 2009
    The epidemiology of amebiasis has dramatically changed since the separation of Entamoeba histolytica and Entamoeba dispar species, and the worldwide prevalence of these species has not been estimated until recently...
  3. ncbi Free-living amoebae as opportunistic and non-opportunistic pathogens of humans and animals
    Frederick L Schuster
    Viral and Rickettsial Disease Laboratory, California Department Health Services, 850 Marina Bay Parkway, Richmond, CA 94804, USA
    Int J Parasitol 34:1001-27. 2004
    ....
  4. ncbi Pathogenic and opportunistic free-living amoebae: Acanthamoeba spp., Balamuthia mandrillaris, Naegleria fowleri, and Sappinia diploidea
    Govinda S Visvesvara
    Division of Parasitic Diseases, National Center for Infectious Diseases, Atlanta, Georgia 30341 3724, USA
    FEMS Immunol Med Microbiol 50:1-26. 2007
    ..We also discuss the clinical profiles, mechanisms of pathogenesis, pathophysiology, immunology, antimicrobial sensitivity and molecular characteristics of these amoebae...
  5. pmc PCR-based diagnosis of Naegleria sp. infection in formalin-fixed and paraffin-embedded brain sections
    Marc Schild
    Institute of Parasitology, University of Berne, Langgass strasse 122, CH 3012 Bern, Switzerland
    J Clin Microbiol 45:564-7. 2007
    ....
  6. ncbi Epidemiology of amebiasis in a region of high incidence of amebic liver abscess in central Vietnam
    Joerg Blessmann
    Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany
    Am J Trop Med Hyg 66:578-83. 2002
    ..prompted the World Health Organization to recommend reinforced efforts for reassessment of the epidemiology of amebiasis and, in particular, of E. histolytica...
  7. pmc The dynamic interdependence of amebiasis, innate immunity, and undernutrition
    Hans P Verkerke
    Division of Infectious Diseases and International Health, University of Virginia Health System, Charlottesville, VA 22903, USA
    Semin Immunopathol 34:771-85. 2012
    ..Efforts to exhaustively characterize the pathogenesis of amebiasis have increased our understanding of the dynamic host-parasite interaction and the process by which E...
  8. ncbi Origin and evolution of the worldwide distributed pathogenic amoeboflagellate Naegleria fowleri
    Johan F De Jonckheere
    Research Unit for Tropical Diseases, de Duve Institute, Brussels, Belgium
    Infect Genet Evol 11:1520-8. 2011
    ..There is no evidence of virulence differences between the types of N. fowleri. Two other Naegleria spp. are pathogenic for mice, but human infections due to these two other Naegleria spp. are not known...
  9. ncbi Amoebiasis
    Samuel L Stanley
    Department of Medicine, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO, St Louis, MO 63110, USA
    Lancet 361:1025-34. 2003
    ..New models of disease have linked E histolytica induction of intestinal inflammation and hepatocyte programmed cell death to the pathogenesis of amoebic colitis and amoebic liver abscess...
  10. ncbi Opportunistic amoebae: challenges in prophylaxis and treatment
    Frederick L Schuster
    Viral and Rickettsial Disease Laboratory, California Department of Health Services, Richmond, CA 94804, USA
    Drug Resist Updat 7:41-51. 2004
    ....
  11. ncbi Amebic keratitis in a wearer of disposable contact lenses due to a mixed Vahlkampfia and Hartmannella infection
    D Aitken
    Department of Ophthalmology, University of Glasgow, Scotland
    Ophthalmology 103:485-94. 1996
    ..Vahlkampfia and Hartmannella, two other genera of free-living ameba, were isolated, however, using prolonged culture...
  12. pmc Acanthamoeba castellanii induces host cell death via a phosphatidylinositol 3-kinase-dependent mechanism
    James Sissons
    School of Biological and Chemical Sciences, Birkbeck, College, University of London, London WC1E 7HX, England, United Kingdom
    Infect Immun 73:2704-8. 2005
    ..This is the first demonstration that Acanthamoeba-mediated brain microvascular endothelial cell death is dependent on phosphatidylinositol 3-kinase...
  13. ncbi Balamuthia mandrillaris, an opportunistic agent of granulomatous amebic encephalitis, infects the brain via the olfactory nerve pathway
    Albrecht F Kiderlen
    Department of Infectious Diseases, Robert Koch Institute, Nordufer 20, 13353 Berlin, Germany
    Parasitol Res 94:49-52. 2004
    ..A similar invasion pathway has been described for N. fowleri. The data suggest that the olfactory nerve pathway is a likely route for natural infection of the brain by B. mandrillaris amebae...
  14. pmc A novel Entamoeba histolytica cysteine proteinase, EhCP4, is key for invasive amebiasis and a therapeutic target
    Chen He
    Department of Pathology and Medicine, University of California, San Diego, California 92103 8416, USA
    J Biol Chem 285:18516-27. 2010
    ..histolytica, the protozoan cause of human amebiasis. EhCPs are encoded by 50 genes, of which ehcp4 (ehcp-a4) is the most up-regulated during invasion and ..
  15. pmc Acanthamoeba spp. as agents of disease in humans
    Francine Marciano-Cabral
    Department of Microbiology and Immunology, Virginia Commonwealth University, Richmond, Virginia 23298 0678, USA
    Clin Microbiol Rev 16:273-307. 2003
    ..Since an increase in the number of cases of Acanthamoeba infections has occurred worldwide, these protozoa have become increasingly important as agents of human disease...
  16. pmc Identification and distribution of Acanthamoeba species genotypes associated with nonkeratitis infections
    Gregory C Booton
    Department of Evolution, Ecology, Organismal Biology, The Ohio State University, 318 W 12th Ave, Columbus, OH 43210, USA
    J Clin Microbiol 43:1689-93. 2005
    ..However, the genotypes that were isolated from brains have not been observed in environmental isolates of Acanthamoeba, and their natural ecological niche is unknown...
  17. pmc PCR detection and analysis of the free-living amoeba Naegleria in hot springs in Yellowstone and Grand Teton National Parks
    Kathy B Sheehan
    Department of Microbiology and Thermal Biology Institute, Montana State University, Bozeman, Montana 59717, USA
    Appl Environ Microbiol 69:5914-8. 2003
    ....
  18. ncbi Screening of Swiss hot spring resorts for potentially pathogenic free-living amoebae
    Christian Gianinazzi
    Institute of Parasitology, University of Berne, Berne, Switzerland
    Exp Parasitol 126:45-53. 2010
    ..healyi were suggestive of being potentially pathogenic to immunocompromised persons. However, the presence of these isolates was limited to the filtration units, and an effective threat for health can therefore be excluded...
  19. ncbi Balamuthia amoebic encephalitis: an emerging disease with fatal consequences
    Ruqaiyyah Siddiqui
    School of Biological and Chemical Sciences, Birkbeck College, University of London, London, UK
    Microb Pathog 44:89-97. 2008
    ..Here, we present a brief overview of the current understanding of the pathogenesis and pathophysiology of BAE, available diagnostic methods, possible therapeutic interventions and biology of the causative agent...
  20. ncbi Eradication of amebiasis in a large institution for adults with mental retardation in Taiwan
    Shih Bin Su
    Department of Environmental and Occupational Health, Tainan Science Based Industrial Park Clinic, National Cheng Kung University, Tainan, Taiwan
    Infect Control Hosp Epidemiol 28:679-83. 2007
    Investigation of a program to eradicate amebiasis using consecutive intensive mass screenings followed by medication in a large institute for adults with mental retardation in Taiwan.
  21. ncbi Invasive amebiasis: a microcirculatory disorder?
    Rafael Campos-Rodríguez
    Departamento de Bioquimica, Escuela Superior de Medicina, Instituto Politecnico Nacional, Plan de San Luis y Diaz Miron, CP 11340 DF, Mexico
    Med Hypotheses 73:687-97. 2009
    The two current models of invasive amebiasis both hold that direct contact of toxic molecules and amebas with tissue produces the necrotic areas characteristic of this disorder...
  22. ncbi Prevalence of acanthamoeba from tap water in rio grande do Sul, Brazil
    Mari Aline Todero Winck
    Departamento de Microbiologia, Imunologia e Parasitogia, Instituto de Ciencias Basicas da Saude, Setor de Parasitologia, Universidade Federal do Rio Grande do Sul, Rua Sarmento Leite, 500, Porto Alegre, RS 90050 170, Brazil
    Curr Microbiol 63:464-9. 2011
    ....
  23. ncbi Balamuthia mandrillaris meningoencephalitis: survival of a pediatric patient
    Larry Curtis Cary
    University of Kentucky College of Medicine, Department of Pediatrics, Pediatric Residency Program, MN118 William R Willard Medical Education Building, 800 Rose St, Lexington, KY 40536 0298, USA
    Pediatrics 125:e699-703. 2010
    ..Our observations suggest that early diagnosis and treatment may significantly reduce mortality and morbidity rates from this highly virulent organism...
  24. ncbi Identification of Acanthamoeba genotype T4 and Paravahlkampfia sp. from two clinical samples
    Soykan Ozkoc
    Department of Parasitology, Faculty of Medicine, Dokuz Eylul University, Izmir, Turkey
    J Med Microbiol 57:392-6. 2008
    ..However, the Paravahlkampfia isolate is believed to be the first strain that has been isolated from a keratitis patient and has been molecularly differentiated from Vahlkampfia...
  25. pmc Assessing the risk of primary amoebic meningoencephalitis from swimming in the presence of environmental Naegleria fowleri
    P A Cabanes
    Service des Etudes Médicales, Electricite de France, 78401 Chatou Cedex, France
    Appl Environ Microbiol 67:2927-31. 2001
    ..This provides the PAM risk in humans as a function of the N. fowleri concentration in the river. For example, the risk is 8.5 x 10(-8) at a concentration of 10 N. fowleri amoebae per liter...
  26. ncbi Successful treatment of Balamuthia mandrillaris amoebic infection with extensive neurological and cutaneous involvement
    Dalila Y Martínez
    Instituto de Medicina Tropical Alexander von Humboldt, Universidad Peruana Cayetano Heredia, Lima, Peru
    Clin Infect Dis 51:e7-11. 2010
    ..We describe a young, female patient who presented with extensive cutaneous and neurological involvement and who recovered after receiving prolonged treatment with miltefosine, fluconazole, and albendazole...
  27. ncbi The public health threat from Balamuthia mandrillaris in the southern United States
    James H Diaz
    Environmental and Occupational Health Sciences, School of Public Health, Louisiana State University Health Sciences Center, New Orleans, USA
    J La State Med Soc 163:197-204. 2011
    ..Brain dead victims of BAE are not suitable organ donors and have transmitted fatal BAE to organ transplant recipients...
  28. ncbi [Amebic granulomatosis encephalitis due to Balamuthia mandrillaris: fatal disease increasingly recognized in Latin America]
    Carlos Seas R
    Rev Chilena Infectol 23:197-9. 2006
  29. ncbi Under the radar: balamuthia amebic encephalitis
    Frederick L Schuster
    California Department of Public Health, Richmond, CA 94804, USA
    Clin Infect Dis 48:879-87. 2009
    ..We present data from 9 years (1999-2008) of tests for Balamuthia mandrillaris, an agent of amebic encephalitis that were conducted as part of the California Encephalitis Project...
  30. ncbi Balamuthia mandrillaris infection of the skin and central nervous system: an emerging disease of concern to many specialties in medicine
    Francisco G Bravo
    Instituto de Medicina Tropical Alexander von Humboldt, Universidad Peruana Cayetano Heredia, Peru
    Curr Opin Infect Dis 24:112-7. 2011
    ..The ability of the clinician in recognizing the skin lesion early in the course of the disease may lead to a successful therapeutic intervention in an otherwise fatal disease...
  31. ncbi Balamuthia mandrillaris brain abscess successfully treated with complete surgical excision and prolonged combination antimicrobial therapy
    Joseph S Doyle
    Infectious Diseases Unit, The Alfred Hospital, Melbourne, Victoria, Australia
    J Neurosurg 114:458-62. 2011
    ..It illustrates the risk of dissemination from cutaneous to cerebral amoebic lesions, potential progression with corticosteroid therapy, and the prospect for curative excision...
  32. ncbi Asymptomatic aneurysm of the cavernous and supraclinoid internal carotid artery in a patient with Balamuthia mandrillaris encephalitis
    Ludwig D Orozco
    Department of Neurosurgery, University of Mississippi Medical Center, 2500 North State Street, Jackson, Mississippi 39216, USA
    J Clin Neurosci 18:1118-20. 2011
    ..This is the first report to demonstrate the risk of aneurysm formation associated with this infection. Prolonged anti-amebic treatment resulted in resolution of the aneurysm without clinical evidence of subarachnoid hemorrhage...
  33. ncbi Epidemiology of amebiasis in Mexico: a molecular approach
    Cecilia Ximenez
    Experimental Medicine Department, Faculty of Medicine, Universidad Nacional Autonoma de Mexico UNAM, Mexico, D F, Mexico
    Arch Med Res 37:263-5. 2006
    ..characterization in the last decade of the twentieth century led to the need to re-evaluate the epidemiology of amebiasis in terms of prevalence and morbidity of the infection in the world's population, particularly in those ..
  34. pmc Short report: Amebiasis-related mortality among United States residents, 1990-2007
    Janelle Gunther
    Department of Epidemiology, UCLA School of Public Health, Los Angeles, California 90095, USA
    Am J Trop Med Hyg 85:1038-40. 2011
    Despite the endemic nature of Entamoeba histolytica infection in the United States there is a lack of data on amebiasis-related mortality...
  35. ncbi Acanthamoeba: biology and increasing importance in human health
    Naveed Ahmed Khan
    School of Biological and Chemical Sciences, Birkbeck College, University of London, London, UK
    FEMS Microbiol Rev 30:564-95. 2006
    ....
  36. pmc Amebiasis in HIV-1-infected Japanese men: clinical features and response to therapy
    Koji Watanabe
    AIDS Clinical Center, National Center for Global Health and Medicine, Tokyo, Japan
    PLoS Negl Trop Dis 5:e1318. 2011
    ..To characterize the clinical and epidemiological features of invasive amebiasis in HIV-1 patients, the medical records of 170 co-infected cases were analyzed retrospectively, and E...
  37. ncbi Amebiasis in Japanese homosexual men with human immunodeficiency virus infection
    S Mitarai
    Department of Respiratory Medicine, National Tokyo Hospital, Kiyose
    Intern Med 40:671-5. 2001
    We report cases of amebiasis in 6 human immunodeficiency virus (HIV)-positive male patients. Five were confirmed homosexuals while one was suspected. Three patients had liver abscess and 5 had colitis with duration of 10 days to months...
  38. ncbi Novel model for the in vivo study of central nervous system infection due to Acanthamoeba spp. (T4 genotype)
    Parisa Nakhostin Mortazavi
    School of Biological and Chemical Sciences, Birkbeck, University of London, London, UK
    J Med Microbiol 58:503-8. 2009
    ..These findings support the view that locusts can be used as a model for the study of Acanthamoeba pathogenesis in vivo...
  39. ncbi Acanthamoeba invasion of the central nervous system
    Naveed Ahmed Khan
    School of Biological and Chemical Sciences, Birkbeck College, University of London, London WC1E 7HX, UK
    Int J Parasitol 37:131-8. 2007
    ..Recent studies have identified several molecular mechanisms associated with Acanthamoeba traversal of the blood-brain barrier and targeting those may help develop therapeutic interventions and/or design preventative strategies...
  40. pmc Parachlamydiaceae as rare agents of pneumonia
    Gilbert Greub
    Emerg Infect Dis 9:755-6. 2003
  41. ncbi Post-mortem culture of Balamuthia mandrillaris from the brain and cerebrospinal fluid of a case of granulomatous amoebic meningoencephalitis, using human brain microvascular endothelial cells
    Samantha Jayasekera
    School of Biological and Chemical Sciences, Birkbeck College University of London, London WC1E 7HX, UK
    J Med Microbiol 53:1007-12. 2004
    ..The role of HBMECs in understanding the interactions of B. mandrillaris with the blood-brain barrier is discussed...
  42. ncbi Histopathologic spectrum and immunohistochemical diagnosis of amebic meningoencephalitis
    Jeannette Guarner
    Infectious Disease Pathology Branch, National Center for Infectious Diseases, Centers for Disease Control and Prevention, 1405 Clifton Road NE, Atlanta, GA 30322, USA
    Mod Pathol 20:1230-7. 2007
    ..The term amebic meningoencephalitis describes better the histopathologic findings than the currently used classification of primary amebic meningoencephalitis and granulomatous amebic encephalitis...
  43. ncbi Epidemiology and treatment of amebiasis in Hué, Vietnam
    Joerg Blessmann
    Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany
    Arch Med Res 37:270-2. 2006
    ..histolytica infections as well as (iii) comparative randomized treatment trials in order to optimize the therapeutic regimen for ALA and for asymptomatic E. histolytica infection...
  44. ncbi Amebiasis
    Bobbi S Pritt
    Division of Clinical Microbiology, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA
    Mayo Clin Proc 83:1154-9; quiz 1159-60. 2008
    b>Amebiasis is defined as infection with Entamoeba histolytica, regardless of associated symptomatology. In resource-rich nations, this parasitic protozoan is seen primarily in travelers to and emigrants from endemic areas...
  45. ncbi Serum zinc and copper levels in southeastern Turkish children with giardiasis or amebiasis
    Z Karakas
    Department of Pediatrics, Istanbul School of Medicine, Istanbul University, Capa, Turkey
    Biol Trace Elem Res 84:11-8. 2001
    ..In this study, the serum Zn and Cu levels in 20 children with giardiasis and in 40 children with amebiasis were evaluated. The serum Zn levels showed a significant decrease when compared to controls (p<0.001)...
  46. ncbi The role of proteases in the differentiation of Acanthamoeba castellanii
    Ricky Dudley
    School of Biological and Chemical Sciences, Birkbeck College, University of London, London, UK
    FEMS Microbiol Lett 286:9-15. 2008
    ..castellanii. Furthermore, both encystment and excystment of A. castellanii was found to be dependent on serine protease function...
  47. ncbi Extracellular proteases of Acanthamoeba castellanii (encephalitis isolate belonging to T1 genotype) contribute to increased permeability in an in vitro model of the human blood-brain barrier
    Selwa Alsam
    School of Biological and Chemical Sciences, Birkbeck College, University of London, London WC1E 7HX, UK
    J Infect 51:150-6. 2005
    ..Objectives of this study were to determine the effects of Acanthamoeba on the permeability of an in vitro blood-brain barrier model and factors contributing to these changes...
  48. pmc Primary meningoencephalitis by Naegleria fowleri: first reported case from Mangalore, South India
    Shalini Shenoy
    Department of Microbiology, Kasturba Medical College, Mangalore, Karnataka, 575001, India
    J Clin Microbiol 40:309-10. 2002
    ..Pathogenic N. fowleri amebae were recovered from samples of water from the well. To our knowledge this case represents the second case of PAM in an infant in the absence of the history of swimming...
  49. ncbi Balamuthia mandrillaris meningoencephalitis: the first case in southeast Asia
    Poj Intalapaporn
    Section of Infectious Diseases, Department of Medicine, Chulalongkorn University, Bangkok, Thailand
    Am J Trop Med Hyg 70:666-9. 2004
    ..To our knowledge, this case is the first reported case of B. mandrillaris in Southeast Asia...
  50. ncbi Prevention of intestinal amebiasis by vaccination with the Entamoeba histolytica Gal/GalNac lectin
    Eric Houpt
    Division of Infectious Diseases and International Health, Department of Medicine, University of Virginia, 300 Lane Rd, PO Box 801340, MR4 Building Room 2115, Charlottesville, VA 22908, USA
    Vaccine 22:611-7. 2004
    ..These results show for the first time that immunization with the Gal/GalNAc lectin can prevent intestinal amebiasis in mice and suggest a protective role for fecal anti-lectin IgA in vivo.
  51. pmc Identification of Naegleria fowleri in domestic water sources by nested PCR
    Francine Marciano-Cabral
    Department of Microbiology and Immunology, Virginia Commonwealth University Medical College of Virginia Campus, Richmond, Virginia 23298 0678, USA
    Appl Environ Microbiol 69:5864-9. 2003
    ..Organisms attached to the filter also tested positive by PCR. The two samples that tested negative for N. fowleri were one that was obtained from a kitchen sink trap and a swipe sample from the garbage disposal of one home...
  52. pmc Granulomatous amoebic encephalitis caused by Acanthamoeba amoebae of genotype T2 in a human immunodeficiency virus-negative patient
    Julia Walochnik
    Department of Medical Parasitology, Clinical Institute of Hygiene and Medical Microbiology, Medical University of Vienna, Kinderspitalgasse 15, 1095 Vienna, Austria
    J Clin Microbiol 46:338-40. 2008
    ..To our knowledge this, is the first case of GAE involving genotype T2...
  53. ncbi Successful treatment of Naegleria fowleri meningoencephalitis by using intravenous amphotericin B, fluconazole and rifampicin
    Jesús Vargas-Zepeda
    Department of Pediatrics, Hospital de Especialidades 1, Centro Medico Nacional Noroeste, Instituto Mexicano del Seguro Social, Ciudad Obregon, Sonora, Mexico
    Arch Med Res 36:83-6. 2005
    ..Primary amebic meningoencephalitis (PAM) is an emerging disease with a rapidly fatal outcome. Only eight reports of cured cases have appeared in the medical literature to date...
  54. pmc Standardized method of measuring acanthamoeba antibodies in sera from healthy human subjects
    C L Chappell
    Center for Infectious Diseases, School of Public Health, University of Texas Health Science Center at Houston, Houston, Texas, USA
    Clin Diagn Lab Immunol 8:724-30. 2001
    ..047) than those from Caucasian subjects. Overall, these data suggest that Acanthamoeba colonization or infection is more common than previously thought. Mild or asymptomatic infections may contribute to the observed serum reactivities...
  55. ncbi Naegleria fowleri hemorrhagic meningoencephalitis: report of two fatalities in children
    Darin T Okuda
    Division of Child Neurology, Barrow Neurological Institute, St Joseph s Hospital and Medical Center, Phoenix, Arizona 85013, USA
    J Child Neurol 19:231-3. 2004
    ..Histopathologic and immunochemistry analysis of brain tissue revealed the presence of Naegleria trophozoites in both cases...
  56. pmc Granulomatous amebic encephalitis in a patient with AIDS: isolation of acanthamoeba sp. Group II from brain tissue and successful treatment with sulfadiazine and fluconazole
    M Seijo Martinez
    Departments of Neurology, Complexo Hospitalario de Pontevedra, HospitalXeral Cies, Vigo, Spain
    J Clin Microbiol 38:3892-5. 2000
    ..We review and discuss the diagnostic microbiologic options for the laboratory diagnosis of infections due to free-living amebae...
  57. pmc Fatal Naegleria fowleri meningoencephalitis, Italy
    Paola E Cogo
    Pediatric Intensive Care, Department of Pediatrics, University of Padova, Padova, Italy
    Emerg Infect Dis 10:1835-7. 2004
    ..Naegleria fowleri was characterized as genotype I on the basis of polymerase chain reaction test results...
  58. ncbi Pathogenesis of Acanthamoeba infections
    Naveed Ahmed Khan
    School of Biological and Chemical Sciences, Birkbeck College, University of London, London WC1E 7HX, UK
    Microb Pathog 34:277-85. 2003
    ..Elucidation of the biochemical, cellular and molecular basis of the pathogenesis of diseases caused by Acanthamoeba may lead to the development of therapeutic interventions...
  59. pmc Inability to make a premortem diagnosis of Acanthamoeba species infection in a patient with fatal granulomatous amebic encephalitis
    Karen C Bloch
    Department of Medicine, Division of Infectious Diseases, A 2200 MCN, Vanderbilt University, Nashville, TN 37232 2605, USA
    J Clin Microbiol 43:3003-6. 2005
    ..Although Acanthamoeba polyphaga that is sensitive to multiple antimicrobials grew from brain tissue, an inability to make a premortem diagnosis precluded therapy...
  60. pmc Detection of Balamuthia mitochondrial 16S rRNA gene DNA in clinical specimens by PCR
    Shigeo Yagi
    California Department of Health Services, Viral and Rickettsial Disease Laboratory, 850 Marina Bay Parkway, Richmond, CA 94804, USA
    J Clin Microbiol 43:3192-7. 2005
    ..2 ameba per reaction mixture. A single Balamuthia ameba contains multiple mitochondrial targets; thus, 0.2 ameba represents multiple targets for amplification and is not equivalent to 0.2 of an ameba as a target...
  61. ncbi Experimental amebiasis: a selected review of some in vivo models
    Victor Tsutsumi
    Departamento de Patologia Experimental, CINVESTAV IPN, Mexico, D F, Mexico
    Arch Med Res 37:210-20. 2006
    The use of in vivo animal models in amebiasis has contributed significantly to the knowledge of this common human parasitic disease...
  62. ncbi Disseminated acanthamoebiasis after lung transplantation
    Alexander G Duarte
    Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Texas Medical Branch, Galveston, Texas 77555 0561, USA
    J Heart Lung Transplant 25:237-40. 2006
    ..Early institution of combination anti-microbial therapy is therefore necessary for effective treatment and prevention of lethal spread to the central nervous system...
  63. pmc Fatal disseminated Acanthamoeba lenticulata infection in a heart transplant patient
    Stephane Barete
    Department of Dermatology and Allergy, Hopital Tenon, Assistance Publique Hopitaux de Paris, France
    Emerg Infect Dis 13:736-8. 2007
    ..The diagnosis was based on skin histopathologic results and confirmed by isolation of the ameba from involved skin and molecular analysis of a partial 18S rRNA gene sequence (DF3)...
  64. ncbi Vaccine prospects for amebiasis
    Omer A Chaudhry
    Division of Infectious Diseases and International Medicine, Department of Internal Medicine, University of Virginia Health System, Charlottesville, VA 22908 1340, USA
    Expert Rev Vaccines 4:657-68. 2005
    ..However, a vaccine for amebiasis could make a significant impact on the morbidity and mortality from the disease...
  65. pmc Characterization of a serine proteinase mediating encystation of Acanthamoeba
    Eun Kyung Moon
    Department of Parasitology, Kyungpook National University School of Medicine, 101 Dongin dong, Joong Gu, Taegu 700 422, South Korea
    Eukaryot Cell 7:1513-7. 2008
    ..Taken together, these results indicate that EMSP plays an important role in the differentiation of Acanthamoeba by promoting autolysis...
  66. ncbi Oral infection of immunocompetent and immunodeficient mice with Balamuthia mandrillaris amebae
    Albrecht F Kiderlen
    Cellular Immunology Unit, Robert Koch Institut, Nordufer 20, 13353, Berlin, Germany
    Parasitol Res 100:775-82. 2007
    ..mandrillaris leading to GAE is possible. Exit from the gastrointestinal tract and dissemination remains unresolved. Though stool cultures were negative, transmission of this highly pathogenic ameba via stool cannot be ruled out...
  67. pmc Acanthamoeba encephalitis in patient with systemic lupus, India
    Charudatt G Shirwadkar
    P D Hinduja National hospital and Research centre, Mumbai, India
    Emerg Infect Dis 12:984-6. 2006
    ..Diagnosis was made by identification of amebas in brain sections by immunofluorescence analysis and confirmed by demonstrating Acanthamoeba mitochondrial 16S rRNA gene DNA in brain tissue sections...
  68. ncbi Encystation in Acanthamoeba castellanii: development of biocide resistance
    D Lloyd
    Department of Microbiology, School of Biosciences, Cardiff University, Wales, United Kingdom
    J Eukaryot Microbiol 48:11-6. 2001
    ..Chlorhexidine diacetate resistance was observed at between 24 and 36 h. The molecular biology and biochemistry of the modifications that underlie these changes are now being investigated...
  69. ncbi Disseminated acanthamebiasis in a renal transplant recipient with osteomyelitis and cutaneous lesions: case report and literature review
    Jordan P Steinberg
    Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD 21209, USA
    Clin Infect Dis 35:e43-9. 2002
    ..Early recognition and treatment may improve clinical outcomes...
  70. pmc Cultivation of pathogenic and opportunistic free-living amebas
    Frederick L Schuster
    Viral and Rickettsial Disease Laboratory, State of California Department of Health Services, Richmond, California 94804, USA
    Clin Microbiol Rev 15:342-54. 2002
    ..The recent identification of another ameba, Sappinia diploidea, suggests that other free-living forms may also be involved as causal agents of human infections...
  71. pmc Early diagnosis of Acanthamoeba infection during routine cytological examination of cerebrospinal fluid
    Franz Petry
    Institute of Medical Microbiology and Hygiene, Johannes Gutenberg University, D 55101 Mainz, Germany
    J Clin Microbiol 44:1903-4. 2006
    ..In the case presented here amebic trophozoites were detected in a routine cerebrospinal fluid sample. The antibiotic treatment and the apparently low virulence of this isolate were responsible for the benign progression of the infection...
  72. ncbi Amebic encephalitis caused by Balamuthia mandrillaris: report of four cases
    Anna Bakardjiev
    Children s Hospital of Oakland, Oakland, CA, USA
    Pediatr Infect Dis J 22:447-53. 2003
    ..Three of the four children developed hydrocephalus during their illness. Increased awareness and timely diagnosis of this disease entity might lead to earlier intervention with improved outcome...
  73. pmc Environmental isolation of Balamuthia mandrillaris associated with a case of amebic encephalitis
    Frederick L Schuster
    California Department of Health Services, Viral and Rickettsial Disease Laboratory, Richmond, CA 94804, USA
    J Clin Microbiol 41:3175-80. 2003
    ..The environmental isolate is similar in its antimicrobial sensitivities and identical in its 16S ribosomal DNA sequences to the Balamuthia isolate from the deceased patient...
  74. ncbi Acanthamoeba and the blood-brain barrier: the breakthrough
    Naveed Ahmed Khan
    School of Biological and Chemical Sciences, Birkbeck College, University of London, London WC1E 7HX, UK
    J Med Microbiol 57:1051-7. 2008
    ..This review of the literature describes the parasite factors and immune-mediated mechanisms involved in the blood-brain barrier dysfunction leading to neuropathogenesis...
  75. pmc Legionella-like and other amoebal pathogens as agents of community-acquired pneumonia
    T J Marrie
    Department of Medicine, University of Alberta, Edmonton, Canada
    Emerg Infect Dis 7:1026-9. 2001
    ..We found that LLAPs play a role (albeit an infrequent one) in community-acquired pneumonia, usually as a co-pathogen but sometimes as the sole identified pathogen...
  76. ncbi Cytopathogenicity of Balamuthia mandrillaris, an opportunistic causative agent of granulomatous amebic encephalitis
    Albrecht F Kiderlen
    Cellular Immunology Unit P22, Robert Koch Institute, D 13353 Berlin, Germany
    J Eukaryot Microbiol 53:456-63. 2006
    ..mandrillaris is essentially cell contact-dependent. Standard and fluorescence light microscopy, as well as scanning and transmission electron microscopy support and extend these findings at the ultrastructural level...
  77. ncbi Detection of antibodies against free-living amoebae Balamuthia mandrillaris and Acanthamoeba species in a population of patients with encephalitis
    Frederick L Schuster
    Viral and Rickettsial Disease Laboratory, California Department of Health Services, Richmond, CA 94804, USA
    Clin Infect Dis 42:1260-5. 2006
    ..We have screened serum samples from hospitalized patients with encephalitis for antibodies against these 2 amoebae as a means of detecting a disease with few defining symptoms and a poor prognosis...
  78. ncbi Successful treatment of Balamuthia amoebic encephalitis: presentation of 2 cases
    Thomas R Deetz
    Infectious Diseases, Santa Cruz Medical Clinic, Santa Cruz, CA, USA
    Clin Infect Dis 37:1304-12. 2003
    ..These 2 individuals are the only known survivors of this otherwise fatal type of amoebic encephalitis...
  79. pmc Diagnosis of first case of Balamuthia amoebic encephalitis in Portugal by immunofluorescence and PCR
    Marta Tavares
    Department of Pediatrics, Hospital de S Joao, Porto, Portugal
    J Clin Microbiol 44:2660-3. 2006
    ..Despite initiation of empirical antimicrobial therapy for balamuthiasis, the patient died 3 weeks after being admitted to the hospital. No source of infection was readily apparent...
  80. ncbi Infection by human immunodeficiency virus-1 is not a risk factor for amebiasis
    Chien Ching Hung
    Am J Trop Med Hyg 75:775; author reply 775-6. 2006
  81. ncbi Spontaneous granulomatous amebic encephalitis: report of four cases from Thailand
    T Sangruchi
    Department of Pathology, Siriraj Hospital Mahidol University, Bangkok, Thailand
    Southeast Asian J Trop Med Public Health 25:309-13. 1994
    ..No visceral involvement was observed. All patients developed "spontaneous" GAE, but we suspect an undiagnosed abnormality in cell mediated immunity or a deficient humoral immune response...
  82. ncbi A case of primary amoebic meningoencephalitis: North Island, New Zealand
    Ray Cursons
    Department of Biological Sciences, University of Waikato, Hillcrest, Hamilton, New Zealand
    N Z Med J 116:U712. 2003
  83. ncbi Prevalence of amebiasis in inflammatory bowel disease in Turkey
    Sebnem Ustun
    Department of Gastroenterology, School of Medicine, University of Ege, 35100, Bornova, Izmir, Turkey
    World J Gastroenterol 9:1834-5. 2003
    To explore the prevalence of amebiasis in inflammatory bowel disease (IBD) in Turkey.
  84. pmc Isolation and molecular typing of Naegleria fowleri from the brain of a cow that died of primary amebic meningoencephalitis
    Govinda S Visvesvara
    Division of Parasitic Diseases, MS F 13, Chamblee Campus, Centers for Diseases Control and Prevention, Atlanta, GA 30341 3724, USA
    J Clin Microbiol 43:4203-4. 2005
    ..We describe here the identification of N. fowleri isolated from the brain of one of several cows that died of PAM based on sequencing of the internal transcribed spacers, including the 5.8S rRNA genes...
  85. ncbi [A case of meningoencephalitis caused by Acanthamoeba sp. in Dakar]
    M Ndiaye
    Service de Neurologie, du CHU Fann Dakar, Senegal
    Med Trop (Mars) 65:67-8. 2005
    ..Species determination by culture on 1.5% agar-agar enriched with Escherichia coli failed. The patient died one month following initiation of treatment using amphotericine B...
  86. ncbi [Detection of Acanthamoeba sp. in environmental samples and in patients' samples by PCR]
    Monika Derda
    Katedra i Zakład Biologii i Parazytologii Lekarskiej, Akademia Medyczna, ul Fredry 10, 61 701 Poznan
    Wiad Parazytol 50:747. 2004
  87. ncbi [Amebicidal plants extracts]
    Monika Derda
    Katedra i Zakład Biologii i Parazytologii Lekarskiej, Akademia Medyczna, ul Fredry 10, 61 701 Poznan
    Wiad Parazytol 50:715-21. 2004
    ..trophozoites in vitro at concentration below 0.1 mg/ml. Further studies are needed to investigate whether these extracts are also effective in vivo in animal model of infection with Acanthamoeba sp...
  88. ncbi Advances in free-living amebae research 2006: summary from the IX International Workshop on Opportunistic Protists (IWOP-9)
    Francine Marciano-Cabral
    Department of Microbiology and Immunology, Virginia Commonwealth University School of Medicine, 1101 E Marshall Street, Richmond, Virginia 23298 0678, USA
    J Eukaryot Microbiol 53:S8-9. 2006
  89. pmc Rapidly fatal Acanthamoeba encephalitis and treatment of cryoglobulinemia
    Wouter Meersseman
    Division of General Internal Medicine, Gasthuisberg University Hospital, Leuven, Belgium
    Emerg Infect Dis 13:469-71. 2007
    ..then developed. Such infections are rare and show an unusually rapid course (possibly related to rituximab)...
  90. ncbi Amebic meningoencephalitis: spectrum of imaging findings
    P Singh
    Department of Radiodiagnosis, Postgraduate Institute of Medical Education and Research, Chandigarh 160012, India
    AJNR Am J Neuroradiol 27:1217-21. 2006
    ..Familiarity with the imaging findings is important for the diagnosis and management of this nearly universally fatal disease...
  91. ncbi Diagnosis of the primary amoebic meningoencephalitis due to Naegleria fowleri
    Tatsuru Hara
    Department of Parasitology, Kurume University School of Medicine, Kurume 830 0011, Japan
    Parasitol Int 54:219-21. 2005
    ..The infecting agent was identified as N. fowleri based on morphologic, serologic and molecular techniques carried out on the isolated organisms...
  92. pmc Ameba-associated microorganisms and diagnosis of nosocomial pneumonia
    Pierre Berger
    Centre Hospitalier Universitaire La Timone, Marseille, France
    Emerg Infect Dis 12:248-55. 2006
    ..This finding suggested its clinical relevance. Therefore, AAM might cause nosocomial pneumonia and should be suspected when conventional microbiologic results are negative...
  93. ncbi [Granulomatous amoebic meningoencephalitis by Balamuthia mandrillaris: case report and literature review]
    Mónica Cuevas P
    Unidad de Lactantes y Nutrición, Servicio de Pediatria, Hospital Luis Calvo Mackenna, Chile
    Rev Chilena Infectol 23:237-42. 2006
    ..mandrillaris cysts and trophozoites. Balamuthia mandrillaris infection should be considered in the differential diagnosis of a patient with chronic granulomatous disease with neurologic symptoms...
  94. pmc Identification and properties of proteases from an Acanthamoeba isolate capable of producing granulomatous encephalitis
    James Sissons
    School of Biological and Chemical Sciences, Birkbeck College, University of London, England, UK
    BMC Microbiol 6:42. 2006
    ..However, the pathogenesis and pathophysiology of Acanthamoeba encephalitis remain unclear. In this study, the role of extracellular Acanthamoeba proteases in central nervous system pathogenesis and pathophysiology was examined...
  95. ncbi Successful treatment of Acanthamoeba rhinosinusitis in a patient with AIDS
    J B Nachega
    Department of Internal Medicine, Universite Catholique de Louvain UCL, Saint Luc University Hospital, Brussels, Belgium
    AIDS Patient Care STDS 19:621-5. 2005
    ..In the era of the HIV/AIDS pandemic, the present report underscores the need for early identification and prompt aggressive treatment to ensure successful management of this rare but potentially fatal opportunistic infection...
  96. pmc Fatal granulomatous Acanthamoeba encephalitis mimicking a stroke, diagnosed by correlation of results of sequential magnetic resonance imaging, biopsy, in vitro culture, immunofluorescence analysis, and molecular analysis
    Mehri S McKellar
    Division of Infectious Diseases, Department of Internal Medicine, University of Utah, Salt Lake City 84132 2405, USA
    J Clin Microbiol 44:4265-9. 2006
    ..We report a unique case of granulomatous amebic encephalitis that was proven pathologically with progressive radiological findings on MRI...
  97. ncbi Fatal case of Naegleria fowleri meningo-encephalitis in an infant: case report
    Shrikiran Hebbar
    Department of Paediatrics, Kasturba Medical College, Manipal, India
    Ann Trop Paediatr 25:223-6. 2005
    ....
  98. ncbi Amphizoic amoebae: pathogenic free-living protozoa; review of the literature and review of cases in Thailand
    Chutatip Siripanth
    Department of Protozoology, Faculty of Tropical Medicine, Mahidol University, Bangkok 10400, Thailand
    J Med Assoc Thai 88:701-7. 2005
    ..About 40% were identified as Acanthamoeba spp., 30% were Naegleria spp., 20% were Hartmanella and 10% were Vahlkampfia. Only 10% of Naegleria spp. belonged to Naegleria fowleri...
  99. ncbi Rapidly expanding brain mass
    A H Gene
    Department of Pathology, Hospital Universitario Son Dureta, Palma de Mallorca, Spain
    Transpl Infect Dis 9:211-3. 2007
    ..He had an active skin rash previously diagnosed as graft-versus-host disease by biopsy. The condition of the patient declined rapidly...
  100. ncbi Primary amoebic meningoencephalitis--rare and lethal
    Rod Ellis-Pegler
    N Z Med J 116:U705. 2003
  101. ncbi [Neurological involvement in free living amebiasis]
    P Campos
    , Universidad Peruana Cayetano Heredia, Lima,
    Rev Neurol 29:316-8. 1999
    ..Is very important to promove in Latin America collaborative studies in order to future actions...

Research Grants41

  1. New Rapid Diagnostic Tests for Amebiasis
    JOEL F HERBEIN; Fiscal Year: 2010
    Our goal is to produce point-of-care diagnostic tests for amebiasis. Entamoeba histolytica is a protozoan parasite and the causative agent of amebiasis in humans...
  2. Planning Grant for the Efficacy of Auranofin for the Treatment of Amebiasis
    Sharon L Reed; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Amebiasis is the third leading cause of death from parasitic infection worldwide, following malaria and schistosomiasis...
  3. A Novel Colon-specific Bi-functional Amebicidal Therapeutics: Gal-Dextran-MM
    Jeoung Soo Lee; Fiscal Year: 2010
    ..treatment with the mixed amebicide, metronidazole, which is effective against both intestinal and systemic amebiasis. One limitation of metronidzole is its high absorption in the upper GI tract , that may result in failure to ..
  4. Molecular Mechanism of Entamoeba histolytica phagocytosis
    Christopher D Huston; Fiscal Year: 2012
    b>Amebiasis ranks second as a protozoan cause of death. Entamoeba histolytica, the etiologic agent, is an intestinal ameba that acquires nutrients by phagocytosis of colonic bacteria, and phagocytosis of host cells by E...
  5. Alum-absorbed subunit vaccine to prevent intestinal amebiasis
    David M Lyerly; Fiscal Year: 2012
    ..vaccine for Entamoeba histolytica and test it in mice for immunogenicity and for protection from intestinal amebiasis. Entamoeba histolytica is a Category B NIH Biodefense pathogen due to its low infectious dose and food and water-..
  6. The Role of Leptin in Susceptibility to Amebiasis
    Chelsea S Marie; Fiscal Year: 2013
    ..DESCRIPTION (provided by applicant): Entamoeba histolytica is the pathogenic protozoan responsible for intestinal amebiasis and amebic liver abscess. E...
  7. Point-of-Care Diagnostic Test for Entamoeba histolytica Cysts
    JOEL F HERBEIN; Fiscal Year: 2013
    ..Dr. Petri at the University of Virginia is an international leader in clinical and basic investigation of amebiasis, and in collaboration with TechLab has developed the only FDA 510(k)-cleared diagnostic test for E. histolytica...
  8. NATURAL IMMUNITY TO ENTAMOEBA HISTOLYTICA
    JONATHAN RAVDIN; Fiscal Year: 1999
    ..However, before work can proceed on development of an amebiasis vaccine we must gain a further understanding of natural immunity to this parasite...
  9. ENTAMOEBA HISTOLYTICA GENOME PROJECT
    Brendan Loftus; Fiscal Year: 2002
    ..b>Amebiasis liver abscess, which can be lethal if left untreated, is the third leading cause of death due to a parasite...
  10. MOLECULAR DISSECTION OF E. HISTOLYTICA PATHOGENESIS
    William F Stenson; Fiscal Year: 2010
    The protozoan parasite Entamoeba histolytica causes amebiasis, which remains a major health problem in much of the world, and is considered a potential biological weapon...
  11. Role of Leptin in Innate Mucosal Defense from Amebiasis
    William A Petri; Fiscal Year: 2013
    ..estimated one-third of all deaths among children and 60% of deaths due to diarrhea, and to the contribution of amebiasis to severe diarrhea in children in the developing world...
  12. Cooperative Research Partnership for an Amebic Colitis Vaccine
    William A Petri; Fiscal Year: 2010
    ..a product of the long-standing partnership of the University of Virginia and TechLab, Inc in applied research on amebiasis. Together we propose to develop and test in mice an acellular vaccine for the prevention of amebic colitis due ..
  13. INTRASPECIES VARIATION IN ENTAMOEBA HISTOLYTICA
    William Petri; Fiscal Year: 1999
    ..The degree of genetic diversity within E. histolytica has important implications for both applied and basic amebiasis. For example, understanding the role of acquired immunity in preventing reinfection with E...
  14. New Diagnostics for Amebiasis
    David Lyerly; Fiscal Year: 2005
    ..I we will continue and expand our developmental work on stool dipstick antigen detection tests for intestinal amebiasis, including critical clinical evaluations in Bangladesh, Vietnam, and Turkey...
  15. MECHANISMS OF E HISTOLYTICA ADHERENCE AND CYTOLYSIS
    JONATHAN RAVDIN; Fiscal Year: 1993
    ..causes disease worldwide; parasite adherence and cytolytic events are crucial in pathogenesis of invasive amebiasis. Our objective is to define the biochemical and molecular basis of amebic adherence and cytolytic activities ..
  16. E. histolytica phagocytosis of apoptotic host cells
    Christopher Huston; Fiscal Year: 2007
    ..D., for a career investigating host-pathogen biology during invasive amebiasis. Entamoeba histolytica, the protozoan cause of amebic colitis and liver abscess, infects an estimated 50 million ..
  17. Microalgal Oral Vaccines for Control of Amebiasis
    Richard Wagner; Fiscal Year: 2004
    ..Completion of the Phase I research objectives will provide an eventual model for investigating the delivery of microalgal oral vaccines to humans using this patent-pending microalgal-based antigen expression and delivery system. ..
  18. SERODIAGNOSIS AND IMMUNOPROPHYLAXIS OF AMEBIASIS
    David Lyerly; Fiscal Year: 1999
    ..DESCRIPTION (Adapted from the Applicant's Abstract): The trophozoites of Entamoeba histolytica, the cause of human amebiasis adhere to colonic mucins, intestinal epithelium and leukocytes via a galactose-specific lectin...
  19. NEW APPROACHES TO THE DIAGNOSIS OF AMEBIASIS
    David Lyerly; Fiscal Year: 2001
    b>Amebiasis, caused by Entamoeba histolytica, is a major problem in developing countries...
  20. Genetic variability of E. histolytica in Turkey
    William Petri; Fiscal Year: 2004
    DESCRIPTION (provided by applicant) Amebiasis is a deadly parasitic infectious disease...
  21. BIOCHEMICAL CYTOLOGY OF GIARDIA AND ENTAMOEBA
    DONALD LINDMARK; Fiscal Year: 1980
    ..In addition, some insight should be obtained into the mode of pathogenicity of aerotolerant anaerobic parasites, and the mechanism of action of antianaerobic drugs used in the treatment of amebiasis and giardiasis.
  22. SURFACE ANTIGENS AND PATHOGENESIS OF AMEBIASIS
    BRUCE TORIAN; Fiscal Year: 1992
    ..term objectives of the proposed research project include the understanding and prevention of the pathogenesis of amebiasis through the study of specific surface antigens...
  23. GALACTOSE LECTIN OF E HISTOLYTICA
    Barbara Mann; Fiscal Year: 2002
    ..Successful completion of these experiments will provide insight into the role and identity of PTK/substrates in lectin-mediated killing and may establish the basis for novel therapeutic or prophylactic measures against amebiasis.
  24. ADHERENCE BLOCKING VACCINE FOR AMEBIASIS
    William Petri; Fiscal Year: 2003
    ..In Project 3, the applicants will attempt to develop a novel adjuvant, based on the ricin B subunit to improve the immunogenicity of proteins in plants. ..
  25. Rapid Diagnostics for Category B Enteropathogens
    William Petri; Fiscal Year: 2007
    ..Successful completion of these studies will yield high throughput diagnostic tests that target multiple enteropathogens simultaneously in a single sample. ..
  26. GENE EXPRESSION IN ENTAMOEBA HISTOLYTICA
    William Petri; Fiscal Year: 2008
    ..Successful completion of these studies will provide insight into transcription regulation of virulence factors by the novel mechanism of direct calcium control of an EF-hand containing transcription factor. ..
  27. DNA Probes for Acanthamoeba Genomics and Epidemiology
    Paul Fuerst; Fiscal Year: 2007
    ..Preliminary results show that this region can be amplified in disparate genotypes. Further, these results may provide potential targets for future treatment, since products of these genes may be antibiotic targets. ..
  28. Mucosal immune regulation in murine amebic colitis
    Eric Houpt; Fiscal Year: 2007
    Amebic colitis is the most common form of amebiasis, a parasitic disease that accounts for 100,000 annual deaths...
  29. CHEMOKINE RECEPTORS AND SIV NEUROPATHOGENESIS
    Susan Westmoreland; Fiscal Year: 2003
    ..We will then assess neuronal cultures for cellular injury and induction of apoptosis. ..
  30. Real-time PCR diagnostic kit for Giardia and Cryptosporidium
    Eric Houpt; Fiscal Year: 2006
    ..A Phase II application is anticipated to validate the final diagnostic test product against immunoassay for an FDA 501 (k) medical device application. [unreadable] [unreadable] [unreadable]..
  31. HIV and the Proteasome in the Aging Human Brain
    Benjamin Gelman; Fiscal Year: 2005
    ..The linkage between brain inflammation and altered neuronal protein turnover could lead to a unifying functional concept of dementia with application to HIV and aging both. ..
  32. Identification of E. histolytica virulence factors
    Molly Hughes; Fiscal Year: 2004
    ..genome project provides an unprecendented opportunity to apply the approaches of genetics to the problem of amebiasis. Three specific aims are proposed: (1) Characterize the host:parasite interface by identifying molecules ..
  33. MYELOPATHY AND NEUROPATHY DURING CHANGING HIV BURDEN
    Benjamin Gelman; Fiscal Year: 2004
    ..Together, the studies we have proposed will provide insights concerning prevalent AIDS morbidities in the HAART era. ..
  34. TEXAS REPOSITORY FOR AIDS NEUROPATHOGENESIS RESEARCH
    Benjamin Gelman; Fiscal Year: 2007
    ..abstract_text> ..
  35. Studies on Macrophage Resistance to Anthrax Lethal Toxin
    Molly Hughes; Fiscal Year: 2004
    ..Successful completion of these studies will yield a fundamental understanding of mechanisms of macrophage resistance to LT. ..
  36. Mouse Strain dependent innate resistance to intestinal amebiasis
    Eric Houpt; Fiscal Year: 2009
    ....
  37. Multiplex bead-PCR diagnosis for AIDS diarrhea
    Eric Houpt; Fiscal Year: 2007
    ..Finally, syndrome-based multiplex diagnosis is the platform of the future for clinical microbiology, and if this assay works on stool it should work on sputum, blood, or spinal fluid. [unreadable] [unreadable] [unreadable]..
  38. Targeted DNA extraction for Tuberculosis PCR from sputum
    Eric Houpt; Fiscal Year: 2007
    ..The most sensitive procedure will be taken in Phase II and adapted to high-throughput DNA extraction platforms and compared against the standard E- MTD assay. [unreadable] [unreadable] [unreadable]..
  39. Dopamine Systems and Neuropsychiatric Changes in HIV/AIDS
    Benjamin B Gelman; Fiscal Year: 2010
    ..The project breaks ground neuroscientifically, as no autopsy study has advanced to a "task specific" behavioral correlation with circuit level anomalies of a specific neurotransmitter system. ..